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Conserved domains on  [gi|568971606|ref|XP_006532264|]
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beta-1,4 N-acetylgalactosaminyltransferase 2 isoform X1 [Mus musculus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3000077

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-420 3.54e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVALDGFPGCtlTSGVVNFFLAHTEQLRRVGFDPILQRVAHGEFFIDGLGR 418
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVI--FGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFA 157

                  ..
gi 568971606  419 LL 420
Cdd:pfam00535 158 LY 159
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-420 3.54e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVALDGFPGCtlTSGVVNFFLAHTEQLRRVGFDPILQRVAHGEFFIDGLGR 418
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVI--FGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFA 157

                  ..
gi 568971606  419 LL 420
Cdd:pfam00535 158 LY 159
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
267-455 3.30e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 56.54  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 267 VTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-----SKEPL-EINDDYVEYYTMPFGKGWFAGRNLAISQVTTKY 339
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNgstdgTAELLaALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 340 VLWVDDDflfsdktkIEVLVDVLEKTeLDVAldgfpgctltsgvvnFFLAHTEQLRRVG-FDPilqrvahgEFFIDG--- 415
Cdd:COG1216   85 LLFLDDD--------TVVEPDWLERL-LAAA---------------CLLIRREVFEEVGgFDE--------RFFLYGedv 132
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568971606 416 -LG-RLL-----VGSCPGVIINHQVRTPPKDpklaaLEKTYDKYRAN 455
Cdd:COG1216  133 dLClRLRkagyrIVYVPDAVVYHLGGASSGP-----LLRAYYLGRNR 174
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
280-413 4.86e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 52.12  E-value: 4.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 280 LKILLQSIRKY-YPDITVIVADD--SKEPLEI------NDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFs 350
Cdd:cd00761   12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568971606 351 DKTKIEVLVDVLEKteldvaldgFPGCTLTSGVVNFFLaHTEQLRRVG-FDPILQRVAHGEFFI 413
Cdd:cd00761   91 LPDWLERLVAELLA---------DPEADAVGGPGNLLF-RRELLEEIGgFDEALLSGEEDDDFL 144
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
267-364 1.11e-06

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 49.22  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  267 VTIATKTFLRPHKLKILLQSIRKYYPDITVIVADDSKEPLEINDDY---------VEYYTMPFGKGWFAGRNL-AISQVT 336
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNENNLKvfknysnpnITYLHYPDLGVPFYEKLLdALEQVE 81
                          90       100
                  ....*....|....*....|....*....
gi 568971606  337 TKYVLWV-DDDFLfsDKTKIEVLVDVLEK 364
Cdd:TIGR04440  82 TPYVVICaDDDFI--IPSGLTECLSFLEA 108
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-420 3.54e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVALDGFPGCtlTSGVVNFFLAHTEQLRRVGFDPILQRVAHGEFFIDGLGR 418
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRYVI--FGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFA 157

                  ..
gi 568971606  419 LL 420
Cdd:pfam00535 158 LY 159
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
267-455 3.30e-09

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 56.54  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 267 VTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-----SKEPL-EINDDYVEYYTMPFGKGWFAGRNLAISQVTTKY 339
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNgstdgTAELLaALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 340 VLWVDDDflfsdktkIEVLVDVLEKTeLDVAldgfpgctltsgvvnFFLAHTEQLRRVG-FDPilqrvahgEFFIDG--- 415
Cdd:COG1216   85 LLFLDDD--------TVVEPDWLERL-LAAA---------------CLLIRREVFEEVGgFDE--------RFFLYGedv 132
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568971606 416 -LG-RLL-----VGSCPGVIINHQVRTPPKDpklaaLEKTYDKYRAN 455
Cdd:COG1216  133 dLClRLRkagyrIVYVPDAVVYHLGGASSGP-----LLRAYYLGRNR 174
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
280-413 4.86e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 52.12  E-value: 4.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 280 LKILLQSIRKY-YPDITVIVADD--SKEPLEI------NDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFs 350
Cdd:cd00761   12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568971606 351 DKTKIEVLVDVLEKteldvaldgFPGCTLTSGVVNFFLaHTEQLRRVG-FDPILQRVAHGEFFI 413
Cdd:cd00761   91 LPDWLERLVAELLA---------DPEADAVGGPGNLLF-RRELLEEIGgFDEALLSGEEDDDFL 144
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
266-370 1.58e-07

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 51.63  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 266 LVTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-SK-------EPLEINDDYVEYYTMPFGKGWFAGRNLAISQVT 336
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQtYPDFEIIVVDDgSTdgtaeilRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82
                         90       100       110
                 ....*....|....*....|....*....|....
gi 568971606 337 TKYVLWVDDDFLFsDKTKIEVLVDVLEKTELDVA 370
Cdd:COG0463   83 GDYIAFLDADDQL-DPEKLEELVAALEEGPADLV 115
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
267-364 1.11e-06

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 49.22  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606  267 VTIATKTFLRPHKLKILLQSIRKYYPDITVIVADDSKEPLEINDDY---------VEYYTMPFGKGWFAGRNL-AISQVT 336
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNENNLKvfknysnpnITYLHYPDLGVPFYEKLLdALEQVE 81
                          90       100
                  ....*....|....*....|....*....
gi 568971606  337 TKYVLWV-DDDFLfsDKTKIEVLVDVLEK 364
Cdd:TIGR04440  82 TPYVVICaDDDFI--IPSGLTECLSFLEA 108
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
276-431 2.53e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 44.47  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 276 RPHKLKILLQSIRKY-YPDITVIV-----ADDSKEPLEINDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLF 349
Cdd:cd04186    8 SLEYLKACLDSLLAQtYPDFEVIVvdnasTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568971606 350 SDKTkIEVLVDVLEKtELDVALDGF--PGCtltsgvvnFFLAHTEQLRRVG-FDPilqrvahgEFF-----IDgLGR--- 418
Cdd:cd04186   88 EPGA-LLELLDAAEQ-DPDVGIVGPkvSGA--------FLLVRREVFEEVGgFDE--------DFFlyyedVD-LCLrar 148
                        170
                 ....*....|....*.
gi 568971606 419 ---LLVGSCPGVIINH 431
Cdd:cd04186  149 lagYRVLYVPQAVIYH 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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