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Conserved domains on  [gi|568957073|ref|XP_006531195|]
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dynein regulatory complex subunit 7 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Transglut_core super family cl17362
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 174-215 1.91e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


The actual alignment was detected with superfamily member pfam01841:

Pssm-ID: 450180 [Multi-domain]  Cd Length: 108  Bit Score: 38.54  E-value: 1.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568957073  174 YSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLD 215
Cdd:pfam01841  41 GDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLRGP 82
PRK10246 super family cl32485
exonuclease subunit SbcC; Provisional
 688-851 3.11e-03

exonuclease subunit SbcC; Provisional


The actual alignment was detected with superfamily member PRK10246:

Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 41.32  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  688 RHQAWESELEVLEiLKLREEEEEAHTLTisiydtKRNEKSKEYREamervlHEEHLRQVEAQLDYLAPFLAQLPPGEKLT 767
Cdd:PRK10246  642 RQQQLLTALAGYA-LTLPQEDEEASWLA------TRQQEAQSWQQ------RQNELTALQNRIQQLTPLLETLPQSDDLP 708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  768 ---------RWQAVRlkDECLSDFKQrlidkanlIQARFEKETQELQKKQQWYQENQVTLTP---EDENLYLSYC--SQA 833
Cdd:PRK10246  709 hseetvaldNWRQVH--EQCLSLHSQ--------LQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALldEET 778

                         170
                  ....*....|....*...
gi 568957073  834 MFRIRILEQRLNRHKELA 851
Cdd:PRK10246  779 LTQLEQLKQNLENQRQQA 796
 
Name Accession Description Interval E-value
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 174-215 1.91e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 38.54  E-value: 1.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568957073  174 YSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLD 215
Cdd:pfam01841  41 GDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLRGP 82
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 688-851 3.11e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 41.32  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  688 RHQAWESELEVLEiLKLREEEEEAHTLTisiydtKRNEKSKEYREamervlHEEHLRQVEAQLDYLAPFLAQLPPGEKLT 767
Cdd:PRK10246  642 RQQQLLTALAGYA-LTLPQEDEEASWLA------TRQQEAQSWQQ------RQNELTALQNRIQQLTPLLETLPQSDDLP 708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  768 ---------RWQAVRlkDECLSDFKQrlidkanlIQARFEKETQELQKKQQWYQENQVTLTP---EDENLYLSYC--SQA 833
Cdd:PRK10246  709 hseetvaldNWRQVH--EQCLSLHSQ--------LQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALldEET 778

                         170
                  ....*....|....*...
gi 568957073  834 MFRIRILEQRLNRHKELA 851
Cdd:PRK10246  779 LTQLEQLKQNLENQRQQA 796
 
Name Accession Description Interval E-value
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 174-215 1.91e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 38.54  E-value: 1.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568957073  174 YSSTTVLKCQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLD 215
Cdd:pfam01841  41 GDAEEFLFTGKGDCEDFASLFVALLRALGIPARYVTGYLRGP 82
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 688-851 3.11e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 41.32  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  688 RHQAWESELEVLEiLKLREEEEEAHTLTisiydtKRNEKSKEYREamervlHEEHLRQVEAQLDYLAPFLAQLPPGEKLT 767
Cdd:PRK10246  642 RQQQLLTALAGYA-LTLPQEDEEASWLA------TRQQEAQSWQQ------RQNELTALQNRIQQLTPLLETLPQSDDLP 708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957073  768 ---------RWQAVRlkDECLSDFKQrlidkanlIQARFEKETQELQKKQQWYQENQVTLTP---EDENLYLSYC--SQA 833
Cdd:PRK10246  709 hseetvaldNWRQVH--EQCLSLHSQ--------LQTLQQQDVLEAQRLQKAQAQFDTALQAsvfDDQQAFLAALldEET 778

                         170
                  ....*....|....*...
gi 568957073  834 MFRIRILEQRLNRHKELA 851
Cdd:PRK10246  779 LTQLEQLKQNLENQRQQA 796
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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