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Conserved domains on  [gi|568937151|ref|XP_006530368|]
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cell cycle checkpoint control protein RAD9B isoform X1 [Mus musculus]

Protein Classification

cell cycle checkpoint control RAD9 family protein( domain architecture ID 12050602)

cell cycle checkpoint control RAD9 family protein, similar to RAD9 which is a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rad9 pfam04139
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ...
21-278 3.69e-129

Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3).


:

Pssm-ID: 427739  Cd Length: 253  Bit Score: 372.85  E-value: 3.69e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151   21 FGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYQwspfatMSDTDLPLNLNCKLAIKSVLPIFR 100
Cdd:pfam04139   1 FSRALQCLSRIGDELYIEISEDGLALTTVNSSRSAYGVVTFSKDFFDKYQ------MLSTDVPPQINCKILVKSILSIFR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  101 CLNYLERSVEKCTVVARADKCRVVIQFFGKHGIKRTHNVYFQDSQPLKIIFEKSLCANILMIKPRLLTEAIALLTSNQEE 180
Cdd:pfam04139  75 SLSALEVTVEKCKIQIDGDKSKVIFQFLCKHGVIKTHKIHYEQSQPLHAVFDKNTCPSTLVINPRVLSDLLVHFTSSTEE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  181 VTFSVTPGNFCLKSLSGELLDLTSSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVMHAPLAIYFDFPGKPV 260
Cdd:pfam04139 155 ITIQLTPDRVLIKSYTDEVNDLTSSLYTELSIDPEEFDQYQLNGDVEITFCFKEFKAILAFAEVLHAPIAMYFSFPGKPL 234
                         250
                  ....*....|....*....
gi 568937151  261 VLSVED-MLLEANFILATL 278
Cdd:pfam04139 235 LLTFKKsSLIEANFILATL 253
 
Name Accession Description Interval E-value
Rad9 pfam04139
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ...
21-278 3.69e-129

Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3).


Pssm-ID: 427739  Cd Length: 253  Bit Score: 372.85  E-value: 3.69e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151   21 FGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYQwspfatMSDTDLPLNLNCKLAIKSVLPIFR 100
Cdd:pfam04139   1 FSRALQCLSRIGDELYIEISEDGLALTTVNSSRSAYGVVTFSKDFFDKYQ------MLSTDVPPQINCKILVKSILSIFR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  101 CLNYLERSVEKCTVVARADKCRVVIQFFGKHGIKRTHNVYFQDSQPLKIIFEKSLCANILMIKPRLLTEAIALLTSNQEE 180
Cdd:pfam04139  75 SLSALEVTVEKCKIQIDGDKSKVIFQFLCKHGVIKTHKIHYEQSQPLHAVFDKNTCPSTLVINPRVLSDLLVHFTSSTEE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  181 VTFSVTPGNFCLKSLSGELLDLTSSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVMHAPLAIYFDFPGKPV 260
Cdd:pfam04139 155 ITIQLTPDRVLIKSYTDEVNDLTSSLYTELSIDPEEFDQYQLNGDVEITFCFKEFKAILAFAEVLHAPIAMYFSFPGKPL 234
                         250
                  ....*....|....*....
gi 568937151  261 VLSVED-MLLEANFILATL 278
Cdd:pfam04139 235 LLTFKKsSLIEANFILATL 253
PCNA cd00577
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ...
17-280 3.68e-36

Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY].


Pssm-ID: 238322 [Multi-domain]  Cd Length: 248  Bit Score: 133.14  E-value: 3.68e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  17 QVKVFGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYQWspfatmsdtdlPLNLNCKLAIKSVL 96
Cdd:cd00577    5 NAKLLKKIVDALSKLVDEANFDITEDGISLQAMDSSHVALVSLFLPKELFEEYRC-----------DEEISLGVNLKSLL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  97 PIFRCLnylerSVEKCTVVARADKCRVVIQFFGKH-GIKRTHNVYFQDSQPLKIIFEKSLCANILMIKPRLLTEAIALLT 175
Cdd:cd00577   74 KILKCA-----GNEDCVTLRADDEDPLKILFESSKgDVTSEFSLKLMDIDSEQLPIPELEYDATVTLPSDELKDIVRDLE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151 176 SNQEEVTFSVTPGNFCLKSlSGELLDltsSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVmHAPLAIYFDF 255
Cdd:cd00577  149 SISDSVTISASKDGFKFSA-EGELGG---ASVTLLPKDSDLLVTIECSEPVSSTYSLKYLKDFTKAAPL-SDKVTLSFGS 223
                        250       260
                 ....*....|....*....|....*.
gi 568937151 256 PGkPVVLSVEDM-LLEANFILATLVD 280
Cdd:cd00577  224 DG-PLSLEFKIAdGGHLTFYLAPKIE 248
 
Name Accession Description Interval E-value
Rad9 pfam04139
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ...
21-278 3.69e-129

Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3).


Pssm-ID: 427739  Cd Length: 253  Bit Score: 372.85  E-value: 3.69e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151   21 FGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYQwspfatMSDTDLPLNLNCKLAIKSVLPIFR 100
Cdd:pfam04139   1 FSRALQCLSRIGDELYIEISEDGLALTTVNSSRSAYGVVTFSKDFFDKYQ------MLSTDVPPQINCKILVKSILSIFR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  101 CLNYLERSVEKCTVVARADKCRVVIQFFGKHGIKRTHNVYFQDSQPLKIIFEKSLCANILMIKPRLLTEAIALLTSNQEE 180
Cdd:pfam04139  75 SLSALEVTVEKCKIQIDGDKSKVIFQFLCKHGVIKTHKIHYEQSQPLHAVFDKNTCPSTLVINPRVLSDLLVHFTSSTEE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  181 VTFSVTPGNFCLKSLSGELLDLTSSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVMHAPLAIYFDFPGKPV 260
Cdd:pfam04139 155 ITIQLTPDRVLIKSYTDEVNDLTSSLYTELSIDPEEFDQYQLNGDVEITFCFKEFKAILAFAEVLHAPIAMYFSFPGKPL 234
                         250
                  ....*....|....*....
gi 568937151  261 VLSVED-MLLEANFILATL 278
Cdd:pfam04139 235 LLTFKKsSLIEANFILATL 253
PCNA cd00577
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ...
17-280 3.68e-36

Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY].


Pssm-ID: 238322 [Multi-domain]  Cd Length: 248  Bit Score: 133.14  E-value: 3.68e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  17 QVKVFGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYQWspfatmsdtdlPLNLNCKLAIKSVL 96
Cdd:cd00577    5 NAKLLKKIVDALSKLVDEANFDITEDGISLQAMDSSHVALVSLFLPKELFEEYRC-----------DEEISLGVNLKSLL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151  97 PIFRCLnylerSVEKCTVVARADKCRVVIQFFGKH-GIKRTHNVYFQDSQPLKIIFEKSLCANILMIKPRLLTEAIALLT 175
Cdd:cd00577   74 KILKCA-----GNEDCVTLRADDEDPLKILFESSKgDVTSEFSLKLMDIDSEQLPIPELEYDATVTLPSDELKDIVRDLE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568937151 176 SNQEEVTFSVTPGNFCLKSlSGELLDltsSVYSEMSFGPEEFDFFQVGLDTEITFCFKELKGILTFSEVmHAPLAIYFDF 255
Cdd:cd00577  149 SISDSVTISASKDGFKFSA-EGELGG---ASVTLLPKDSDLLVTIECSEPVSSTYSLKYLKDFTKAAPL-SDKVTLSFGS 223
                        250       260
                 ....*....|....*....|....*.
gi 568937151 256 PGkPVVLSVEDM-LLEANFILATLVD 280
Cdd:cd00577  224 DG-PLSLEFKIAdGGHLTFYLAPKIE 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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