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Conserved domains on  [gi|568936949|ref|XP_006530270|]
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paxillin isoform X5 [Mus musculus]

Protein Classification

Paxillin domain-containing protein( domain architecture ID 11143471)

Paxillin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Paxillin pfam03535
Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily ...
 54-253 2.74e-81

Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily to sites of cell adhesion to the extracellular matrix (ECM) called focal adhesions. The family here represents the N-terminal regions with the proline-rich part as well as the Paxillin part. Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM proteins, such as fibronectin, collagen and laminin. Importantly, focal adhesion proteins including paxillin also serve as a point of convergence for signals resulting from stimulation of various classes of growth factor receptor.


:

Pssm-ID: 460962  Cd Length: 198  Bit Score: 253.29  E-value: 2.74e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949   54 SSEALNGTVLDPLDQWQPSGSRYAHQqppSPLPVYSSSAKNSSASNTQDgvgslcsrAGEEEHVYSFPNKQKSAEPSPTV 133
Cdd:pfam03535  11 SSEALNGTVLDPLDQWQPSQSRYIQQ---SQSPAQKSSWSRDSSSPPRP--------AGEEEHVYSFPNKQKSSDSSPTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949  134 MSSSLGSNLSELDRLLLELNAVQHSPPGFPADEAESSPPLPGALSPLYgIPENNTPLGGKAGPLVKEKPKRNGGRGLEDV 213
Cdd:pfam03535  80 MSSSLGSNLSELDRLLLELNAVQHSSPGFPTDAEEAAPPLPSCSIPHY-IPENGGSLGGKATPPTKEKPKRNGGRGIEDV 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568936949  214 RPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQ 253
Cdd:pfam03535 159 RPSVESLLDELESSVPSPVPAPTVNQGEMSSPQRVTSSQQ 198
 
Name Accession Description Interval E-value
Paxillin pfam03535
Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily ...
 54-253 2.74e-81

Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily to sites of cell adhesion to the extracellular matrix (ECM) called focal adhesions. The family here represents the N-terminal regions with the proline-rich part as well as the Paxillin part. Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM proteins, such as fibronectin, collagen and laminin. Importantly, focal adhesion proteins including paxillin also serve as a point of convergence for signals resulting from stimulation of various classes of growth factor receptor.


Pssm-ID: 460962  Cd Length: 198  Bit Score: 253.29  E-value: 2.74e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949   54 SSEALNGTVLDPLDQWQPSGSRYAHQqppSPLPVYSSSAKNSSASNTQDgvgslcsrAGEEEHVYSFPNKQKSAEPSPTV 133
Cdd:pfam03535  11 SSEALNGTVLDPLDQWQPSQSRYIQQ---SQSPAQKSSWSRDSSSPPRP--------AGEEEHVYSFPNKQKSSDSSPTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949  134 MSSSLGSNLSELDRLLLELNAVQHSPPGFPADEAESSPPLPGALSPLYgIPENNTPLGGKAGPLVKEKPKRNGGRGLEDV 213
Cdd:pfam03535  80 MSSSLGSNLSELDRLLLELNAVQHSSPGFPTDAEEAAPPLPSCSIPHY-IPENGGSLGGKATPPTKEKPKRNGGRGIEDV 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568936949  214 RPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQ 253
Cdd:pfam03535 159 RPSVESLLDELESSVPSPVPAPTVNQGEMSSPQRVTSSQQ 198
 
Name Accession Description Interval E-value
Paxillin pfam03535
Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily ...
 54-253 2.74e-81

Paxillin family; Paxillin is a multi-domain protein that localizes in cultured cells primarily to sites of cell adhesion to the extracellular matrix (ECM) called focal adhesions. The family here represents the N-terminal regions with the proline-rich part as well as the Paxillin part. Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM proteins, such as fibronectin, collagen and laminin. Importantly, focal adhesion proteins including paxillin also serve as a point of convergence for signals resulting from stimulation of various classes of growth factor receptor.


Pssm-ID: 460962  Cd Length: 198  Bit Score: 253.29  E-value: 2.74e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949   54 SSEALNGTVLDPLDQWQPSGSRYAHQqppSPLPVYSSSAKNSSASNTQDgvgslcsrAGEEEHVYSFPNKQKSAEPSPTV 133
Cdd:pfam03535  11 SSEALNGTVLDPLDQWQPSQSRYIQQ---SQSPAQKSSWSRDSSSPPRP--------AGEEEHVYSFPNKQKSSDSSPTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568936949  134 MSSSLGSNLSELDRLLLELNAVQHSPPGFPADEAESSPPLPGALSPLYgIPENNTPLGGKAGPLVKEKPKRNGGRGLEDV 213
Cdd:pfam03535  80 MSSSLGSNLSELDRLLLELNAVQHSSPGFPTDAEEAAPPLPSCSIPHY-IPENGGSLGGKATPPTKEKPKRNGGRGIEDV 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568936949  214 RPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQ 253
Cdd:pfam03535 159 RPSVESLLDELESSVPSPVPAPTVNQGEMSSPQRVTSSQQ 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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