BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  19 FPEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECG 98
Cdd:cd18367    1 FPEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERE 80

                         90       100
                 ....*....|....*....|
gi 569011849  99 RLHREAEYFKLPELAKMLAP 118
Cdd:cd18367   81 RLKREAEYFQLPELVKALRA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  19 FPEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECG 98
Cdd:cd18367    1 FPEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERE 80

                         90       100
                 ....*....|....*....|
gi 569011849  99 RLHREAEYFKLPELAKMLAP 118
Cdd:cd18367   81 RLKREAEYFQLPELVKALRA 100

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849    23 IELNVGGQVYITRYPTLISIPGSRLwEMFSVKNPCSliqDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHfpECGRLHR 102
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFK-ALFSSDFKES---DKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLE 75

                           90
                   ....*....|...
gi 569011849   103 EAEYFKLPELAKM 115
Cdd:smart00225  76 LADYLQIPGLVEL 88

H1 domain found in potassium channel tetramerization domain-containing protein 12; Potassium channel tetramerization domain-containing protein 12 (KCTD12), also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors associated with mood disorders. It regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. KCTD12 consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849 175 KAGFITIGYRGSYTLGRDSQADAKFRRVARIMVCGKISLAKEVFGDTLNESRDPDRPPERYTSRYYLKFTFLEQAFDKLA 254
Cdd:cd22217    1 RSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569011849 255 DAGFHMVACNSTGTCTVT-HDQTDDRIWTSYTEYVFYRE 292
Cdd:cd22217   81 ESGFHMVACSSTGTCAFAsTDQSEDKIWTSYTEYVFCRE 119

H1 domain found in potassium channel tetramerization domain-containing protein 16; Potassium channel tetramerization domain-containing protein 16 (KCTD16) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-) receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. KCTD16 generates largely non-desensitizing receptor responses. It consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits. In the related protein KCTD12, the H1 domain is also responsible for desensitization. This model corresponds to the H1 domain of KCTD16, which may not be involved in desensitization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849 174 KKAGFITIGYRGSYTLGRDSQADAKFRRVARIMVCGKISLAKEVFGDTLNESRDPDRPPERYTSRYYLKFTFLEQAFDKL 253
Cdd:cd22219    2 RKWGFITVGYRGSCTMGRESQADAKFRRVPRILVCGRIALAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDML 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569011849 254 ADAGFHMVACNSTGTCTVTHDQTDDRIWTSYTEYVFYRE 292
Cdd:cd22219   82 SECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYRE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  19 FPEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECG 98
Cdd:cd18367    1 FPEIVELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERE 80

                         90       100
                 ....*....|....*....|
gi 569011849  99 RLHREAEYFKLPELAKMLAP 118
Cdd:cd18367   81 RLKREAEYFQLPELVKALRA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  19 FPEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCS--LIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPE 96
Cdd:cd18398    1 FPEVVELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDTAndLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPE 80

                         90       100
                 ....*....|....*....|..
gi 569011849  97 CGRLHREAEYFKLPELAKMLAP 118
Cdd:cd18398   81 KGRLKREAEYFQLPDLVKLLTP 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKnpCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLHR 102
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGR--WPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVELEELLA 78

                 ....*
gi 569011849 103 EAEYF 107
Cdd:cd18316   79 EAEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  22 IIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLiqDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLH 101
Cdd:cd18364    1 LVTLNVGGYLYITQRQTLTKYPDSFLEGMVNGKIQCTV--DADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLA 78

                 ....*...
gi 569011849 102 REAEYFKL 109
Cdd:cd18364   79 LEADFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  20 PEIIELNVGGQVYITRYPTLISIPGSRLWEMFSvkNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVvlPDHFPEcgR 99
Cdd:cd18371    1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELFN--GQPKLRTDSEGRYFIDRDGTYFRYILEYLRTNQV--PTQHIQ--E 74

                         90
                 ....*....|....*..
gi 569011849 100 LHREAEYFKLPELAKML 116
Cdd:cd18371   75 VYKEALFYDIEPLVKLL 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPcsLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLP-DHFPECGRLH 101
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFSGRHS--LKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPtEDRSVLKELL 78

                         90
                 ....*....|.
gi 569011849 102 REAEYFKLPEL 112
Cdd:cd18376   79 EEAEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  19 FPEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNpcSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDhfpECG 98
Cdd:cd18366    2 FPEVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRH--HIPKDSEGRYFIDRDGSYFGYILNFLRDGDLPPRE---RAR 76

                         90
                 ....*....|....
gi 569011849  99 RLHREAEYFKLPEL 112
Cdd:cd18366   77 AVYKEAQYYGIGPL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLiQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLHR 102
Cdd:cd18388    4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVL-DSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLYE 82

                         90
                 ....*....|....
gi 569011849 103 EAEYFKLPELAKML 116
Cdd:cd18388   83 EAKYYQLQPMVKEL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLiQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLHR 102
Cdd:cd18387    5 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVL-DSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSLLYE 83

                         90
                 ....*....|
gi 569011849 103 EAEYFKLPEL 112
Cdd:cd18387   84 EAKYFQLQPM 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  21 EIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPcsLIQDNKGRFFIDRDGFLFRYVLDYMRDmQVVLPDHFPECGRL 100
Cdd:cd18372    1 DVLRLNVGGCIYTARRESLCRFKDSMLSSMFSGRFP--LKLDESGACVIDRDGRLFKYLLDYLHG-ELQIPEDEQTRLAL 77

                         90       100
                 ....*....|....*....|...
gi 569011849 101 HREAEYFKLP---ELAKMLAPKM 120
Cdd:cd18372   78 QEEADYFGIPypySLTDHLANEM 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  21 EIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKnpCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDhfPECGRL 100
Cdd:cd18363    2 DIINLNVGGKRFSTSRQTLTWIPDSFFTSLLSGR--ISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDLRN--VDISSL 77

                 ....*..
gi 569011849 101 HREAEYF 107
Cdd:cd18363   78 RHEAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLiSIPGSRLWEMFSVKNPCSLiqDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLHR 102
Cdd:cd18400    4 VKLNVGGSLHYTTVQTL-TKQDTMLKAMFSGRVEVLT--DSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELEELLG 80

                         90
                 ....*....|
gi 569011849 103 EAEYFKLPEL 112
Cdd:cd18400   81 EARYYLVQGL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVY------ITRYPTLisipgsrLWEMFSVKnpCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPE 96
Cdd:cd18401    5 VRLNVGGSLYyttvqvLTRHDTM-------LKAMFSGR--MEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQE 75

                         90       100
                 ....*....|....*....|....
gi 569011849  97 CGRLHREAEYFKLPELAKMLAPKM 120
Cdd:cd18401   76 IKELMAEAKYYLIQGLVDMCQAAL 99

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWemfsvKNPCSLIQDNKGRFFIDRDGFLFRYVLDYM 83
Cdd:cd18373    1 FYFNVGGWIFSVPKSKLAQFPDSLLW-----KEASSLSESENTRLFIDRDGFTFRHVHYYL 56

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDHFPECGRLhR 102
Cdd:cd18389    3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL-E 81

                         90
                 ....*....|....*...
gi 569011849 103 EAEYFKLPELAKMLAPKM 120
Cdd:cd18389   82 EAEFYNIASLVRLVKERI 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  21 EIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKnpCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQvvLPDHFPECGRL 100
Cdd:cd18393    2 EVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGR--ISTLKDETGAIFIDRDPTVFAPILNFLRTKE--LDPRGIHVSLL 77

                         90
                 ....*....|....*.
gi 569011849 101 HREAEYFKLPELAKML 116
Cdd:cd18393   78 LHEAQFYGITPLVRRL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  21 EIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKnpCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVVLPDhfPECGRL 100
Cdd:cd18392    2 EIIQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR--ISSLKDETGAIFIDRDPTAFVPILNFLRTKELDLRG--VNINVL 77

                 ....*..
gi 569011849 101 HREAEYF 107
Cdd:cd18392   78 RHEAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNKGRFFIDRDGFLFRYVLDYMRDMQVvlpdHFPE--CGRL 100
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFDYDPVTGEFFFDRHPGVFAQILNYYRTGKL----HCPAdvCGPL 76

                 ...
gi 569011849 101 HRE 103
Cdd:cd18379   77 FEE 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  20 PEIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQDNK-GRFFIDRDGFLFRYVLDYMRDMQVVLPDHFpeCG 98
Cdd:cd18414    2 SDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDPRaDEFFFDRHPGVFAHILNYYRTGKLHCPADV--CG 79

                 ....*....
gi 569011849  99 RLHREAEYF 107
Cdd:cd18414   80 PLYEEELAF 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  23 IELNVGGQVYITRYPTLISIPGSRLWEMFSVKNPCSLIQ------DNKGRFFIDRDGFLFRYVLdymrdmqvvlpdHFPE 96
Cdd:cd18427    2 ISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILElcddydDTKNEFYFDRNPELFPYVL------------HFYN 69

                 ....*....
gi 569011849  97 CGRLHREAE 105
Cdd:cd18427   70 TGKLHVMGE 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849  21 EIIELNVGGQVYITRYPTLISIPGSRLWEMFSVKNP------CSLIQDNKGR------FFIDRDGFLFRYVLDYMRDMQV 88
Cdd:cd18415    2 ERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQgdcltqCSQVGGSDGSpgggneFFFDRHPGVFAYVLNYYRTGKL 81

                         90
                 ....*....|....*..
gi 569011849  89 vlpdHFPE--CGRLHRE 103
Cdd:cd18415   82 ----HCPAdvCGPLFEE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011849   3 MPEKSSDVKPTEEcgsfpEIIELNVGGQVYIT------RYP-TLIsipGSRLWEMFsvknpcslIQDNKGRFFIDRDGFL 75
Cdd:cd18417   22 MPKPPSDKKRRND-----EILVVNVSGRRFQTwkntldRYPdTLL---GSSEKEFF--------YNEDTQEYFFDRDPEM 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569011849  76 FRYVLDYMRDMQVVLPDHfpECGRLHRE--AEYFKLPEL 112
Cdd:cd18417   86 FRHILNFYRTGRLHYPRH--ECIQAFDEelSFYGIIPEI 122