NCBI Conserved Domain Search

Conserved domains on [gi|569011633|ref|XP_006528736|]

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sex comb on midleg-like protein 2 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MBT super family

cl45897

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

9-139

1.07e-71

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

The actual alignment was detected with superfamily member cd20105:

Pssm-ID: 459242 Cd Length: 131 Bit Score: 233.35 E-value: 1.07e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   9 HFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVD 88
Cdd:cd20105    1 HFSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569011633  89 SSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKE 139
Cdd:cd20105   81 SSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

737-846

3.15e-51

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.

Pssm-ID: 463469 Cd Length: 112 Bit Score: 175.47 E-value: 3.15e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  737 TVCVYINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRG-GEMITAFFDGKVHTV 815
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 569011633  816 QLPPVNSASFALRFLENFCQSLQ-CDNFLSSQ 846
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

MBT_dScm-like_rpt2

cd20092

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...

144-218

9.71e-46

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 158.29 E-value: 9.71e-46

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20092    1 PEKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPPG 75

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

922-992

4.97e-35

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.

Pssm-ID: 188977 Cd Length: 72 Bit Score: 127.54 E-value: 4.97e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 922 KDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKE 992
Cdd:cd09578    2 KDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

PTZ00121 super family

cl31754

MAEBL; Provisional

263-602

1.50e-07

MAEBL; Provisional

The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 55.92 E-value: 1.50e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  263 DENRTLKDCRgEAAEEPGTSAFTFGDENRtlKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPrgrgftqpleD 342
Cdd:PTZ00121 1209 EEERKAEEAR-KAEDAKKAEAVKKAEEAK--KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA----------E 1275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  343 EARPGRDVQvaPAEKKRKGKTVTTpwTEDPRLfADQGDAPAEKKRKGKTVTTPwTEDPRLFADQGDAPAEKKRKGktvtt 422
Cdd:PTZ00121 1276 EARKADELK--KAEEKKKADEAKK--AEEKKK-ADEAKKKAEEAKKADEAKKK-AEEAKKKADAAKKKAEEAKKA----- 1344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  423 pwTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLF------------ADQ 490
Cdd:PTZ00121 1345 --AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAdelkkaaaakkkADE 1422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  491 GDAPAEKKRKGKTVTTPWTEDPRlfADQGAAPAEKKRKGKTVTTPWTEDPRlfADQGDAPAEKKRKGKTVTTPwTEDPRL 570
Cdd:PTZ00121 1423 AKKKAEEKKKADEAKKKAEEAKK--ADEAKKKAEEAKKAEEAKKKAEEAKK--ADEAKKKAEEAKKADEAKKK-AEEAKK 1497

                         330       340       350
                  ....*....|....*....|....*....|..
gi 569011633  571 FADQGDAPAEKKpkgKRVTKSRKDQAQFLADE 602
Cdd:PTZ00121 1498 KADEAKKAAEAK---KKADEAKKAEEAKKADE 1526

Name

Accession

Description

Interval

E-value

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

9-139

1.07e-71

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 233.35 E-value: 1.07e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   9 HFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVD 88
Cdd:cd20105    1 HFSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569011633  89 SSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKE 139
Cdd:cd20105   81 SSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

737-846

3.15e-51

Pssm-ID: 463469 Cd Length: 112 Bit Score: 175.47 E-value: 3.15e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  737 TVCVYINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRG-GEMITAFFDGKVHTV 815
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 569011633  816 QLPPVNSASFALRFLENFCQSLQ-CDNFLSSQ 846
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

MBT_dScm-like_rpt2

cd20092

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...

144-218

9.71e-46

Pssm-ID: 439082 Cd Length: 75 Bit Score: 158.29 E-value: 9.71e-46

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20092    1 PEKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPPG 75

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

126-217

7.29e-40

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 142.39 E-value: 7.29e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   126 LTGSELAPAVFFKEEPPRPlQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVG 205
Cdd:smart00561   6 ETGARAAPVELFKQPVDSP-PNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDIFPVG 84

                           90
                   ....*....|..
gi 569011633   206 WCRLTGDVLQPP 217
Cdd:smart00561  85 WCEKNGHPLQPP 96

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

13-108

6.26e-36

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 131.22 E-value: 6.26e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633    13 DKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDI 92
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 569011633    93 QPVGTCEQGGDLLQPP 108
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

922-992

4.97e-35

Pssm-ID: 188977 Cd Length: 72 Bit Score: 127.54 E-value: 4.97e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 922 KDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKE 992
Cdd:cd09578    2 KDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

153-217

1.45e-34

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 126.09 E-value: 1.45e-34

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633  153 MKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

44-109

2.60e-26

Pssm-ID: 460712 Cd Length: 66 Bit Score: 102.59 E-value: 2.60e-26

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011633   44 MKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

PTZ00121

MAEBL; Provisional

263-602

1.50e-07

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 55.92 E-value: 1.50e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  263 DENRTLKDCRgEAAEEPGTSAFTFGDENRtlKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPrgrgftqpleD 342
Cdd:PTZ00121 1209 EEERKAEEAR-KAEDAKKAEAVKKAEEAK--KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA----------E 1275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  343 EARPGRDVQvaPAEKKRKGKTVTTpwTEDPRLfADQGDAPAEKKRKGKTVTTPwTEDPRLFADQGDAPAEKKRKGktvtt 422
Cdd:PTZ00121 1276 EARKADELK--KAEEKKKADEAKK--AEEKKK-ADEAKKKAEEAKKADEAKKK-AEEAKKKADAAKKKAEEAKKA----- 1344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  423 pwTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLF------------ADQ 490
Cdd:PTZ00121 1345 --AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAdelkkaaaakkkADE 1422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  491 GDAPAEKKRKGKTVTTPWTEDPRlfADQGAAPAEKKRKGKTVTTPWTEDPRlfADQGDAPAEKKRKGKTVTTPwTEDPRL 570
Cdd:PTZ00121 1423 AKKKAEEKKKADEAKKKAEEAKK--ADEAKKKAEEAKKAEEAKKKAEEAKK--ADEAKKKAEEAKKADEAKKK-AEEAKK 1497

                         330       340       350
                  ....*....|....*....|....*....|..
gi 569011633  571 FADQGDAPAEKKpkgKRVTKSRKDQAQFLADE 602
Cdd:PTZ00121 1498 KADEAKKAAEAK---KKADEAKKAEEAKKADE 1526

SAM_1

pfam00536

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...

925-991

2.07e-07

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.

Pssm-ID: 425739 Cd Length: 64 Bit Score: 48.80 E-value: 2.07e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011633  925 STWSVDEVIQFMKHTDPqisGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLK 991
Cdd:pfam00536   1 DGWSVEDVGEWLESIGL---GQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64

SAM

smart00454

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...

924-992

3.77e-07

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.

Pssm-ID: 197735 Cd Length: 68 Bit Score: 48.06 E-value: 3.77e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   924 PSTWSVDEVIQFMKHTDPQisgPLADLFRQHEIDGKALLLLKSELLMKYMG-LKLGPAVKLCYYIEKLKE 992
Cdd:smart00454   1 VSQWSPESVADWLESIGLE---QYADNFRKNGIDGALLLLLTSEEDLKELGiTKLGHRKKILKAIQKLKE 67

Name

Accession

Description

Interval

E-value

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

9-139

1.07e-71

Pssm-ID: 439095 Cd Length: 131 Bit Score: 233.35 E-value: 1.07e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   9 HFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVD 88
Cdd:cd20105    1 HFSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569011633  89 SSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKE 139
Cdd:cd20105   81 SSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

MBT_SCML2_rpt1

cd20106

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...

31-128

2.01e-65

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 214.79 E-value: 2.01e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  31 QSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLG 110
Cdd:cd20106    1 QSRIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLG 80

                         90
                 ....*....|....*...
gi 569011633 111 YTLNTSSWPMFLLRVLTG 128
Cdd:cd20106   81 FQMNASSWPMFLLRTLNG 98

MBT_dScm-like_rpt1

cd20091

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...

31-127

4.36e-59

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 196.75 E-value: 4.36e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  31 QSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLG 110
Cdd:cd20091    1 QSPIPPVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLG 80

                         90
                 ....*....|....*..
gi 569011633 111 YTLNTSSWPMFLLRVLT 127
Cdd:cd20091   81 FRMNPSSWPMFLQKTLN 97

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

737-846

3.15e-51

Pssm-ID: 463469 Cd Length: 112 Bit Score: 175.47 E-value: 3.15e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  737 TVCVYINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDNRG-GEMITAFFDGKVHTV 815
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 569011633  816 QLPPVNSASFALRFLENFCQSLQ-CDNFLSSQ 846
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

MBT_dScm_rpt1

cd20107

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...

31-126

1.91e-50

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 172.80 E-value: 1.91e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  31 QSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLG 110
Cdd:cd20107    1 QAQNPPKNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLG 80

                         90
                 ....*....|....*.
gi 569011633 111 YTLNTSSWPMFLLRVL 126
Cdd:cd20107   81 FRMNASSWPMFLLKTL 96

MBT_dScm-like_rpt2

cd20092

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...

144-218

9.71e-46

Pssm-ID: 439082 Cd Length: 75 Bit Score: 158.29 E-value: 9.71e-46

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20092    1 PEKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPPG 75

MBT_SCML2_rpt2

cd20109

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...

144-218

1.29e-43

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 152.35 E-value: 1.29e-43

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20109    1 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPPG 75

MBT_dScm_rpt2

cd20110

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

144-218

7.21e-43

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 150.30 E-value: 7.21e-43

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20110    1 PESNLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGHPLQPPG 75

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

126-217

7.29e-40

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 142.39 E-value: 7.29e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   126 LTGSELAPAVFFKEEPPRPlQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVG 205
Cdd:smart00561   6 ETGARAAPVELFKQPVDSP-PNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDIFPVG 84

                           90
                   ....*....|..
gi 569011633   206 WCRLTGDVLQPP 217
Cdd:smart00561  85 WCEKNGHPLQPP 96

MBT_SCMH1_rpt2

cd20108

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

144-218

9.81e-40

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 141.23 E-value: 9.81e-40

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633 144 PLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG 218
Cdd:cd20108    1 PSQNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPPG 75

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

13-108

6.26e-36

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 131.22 E-value: 6.26e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633    13 DKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDI 92
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 569011633    93 QPVGTCEQGGDLLQPP 108
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

922-992

4.97e-35

Pssm-ID: 188977 Cd Length: 72 Bit Score: 127.54 E-value: 4.97e-35

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 922 KDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKE 992
Cdd:cd09578    2 KDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

153-217

1.45e-34

Pssm-ID: 460712 Cd Length: 66 Bit Score: 126.09 E-value: 1.45e-34

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633  153 MKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

MBT_L3MBTL1-like_rpt2

cd20102

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

147-217

2.97e-30

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 114.65 E-value: 2.97e-30

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 147 NNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20102    2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72

MBT_dSfmbt-like_rpt4

cd20100

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

147-217

1.43e-28

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 109.30 E-value: 1.43e-28

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 147 NNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

MBT_L3MBTL1-like_rpt1

cd20101

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

35-137

1.10e-26

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 105.04 E-value: 1.10e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  35 PPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLN 114
Cdd:cd20101    1 FNKNGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSE 80

                         90       100
                 ....*....|....*....|...
gi 569011633 115 TSSWPMFLlrVLTGSELAPAVFF 137
Cdd:cd20101   81 TFSWSAYL--KLTKAQAAPKHLF 101

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

44-109

2.60e-26

Pssm-ID: 460712 Cd Length: 66 Bit Score: 102.59 E-value: 2.60e-26

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011633   44 MKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

MBT

cd20088

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

149-208

5.10e-25

Pssm-ID: 439080 Cd Length: 61 Bit Score: 98.87 E-value: 5.10e-25

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWS-GAFDYWCDYDSRDIFPVGWCR 208
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDpSRYDFWCDVDSPDIHPVGWCE 61

MBT_L3MBTL1-like_rpt1

cd20101

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

147-217

1.31e-24

Pssm-ID: 439091 Cd Length: 101 Bit Score: 98.88 E-value: 1.31e-24

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 147 NNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20101    4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPP 74

MBT_L3MBTL4_rpt2

cd20136

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

5.89e-24

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 97.00 E-value: 5.89e-24

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAP 73

MBT_L3MBTL1-like_rpt3

cd20103

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

149-217

1.14e-23

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 95.42 E-value: 1.14e-23

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20103    5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

MBT_L3MBTL1-like_rpt2

cd20102

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

37-118

1.07e-22

Pssm-ID: 439092 Cd Length: 90 Bit Score: 93.08 E-value: 1.07e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  37 TNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTS 116
Cdd:cd20102    1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGNF 80


                 ..
gi 569011633 117 SW 118
Cdd:cd20102   81 SW 82

SAM_Polycomb

cd09509

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a ...

924-989

4.77e-22

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.

Pssm-ID: 188908 Cd Length: 64 Bit Score: 90.23 E-value: 4.77e-22

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011633 924 PSTWSVDEVIQFMKHTDpqISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEK 989
Cdd:cd09509    1 PSKWSVDDVAQFIKSLD--GCAEYAEVFREQEIDGQALLLLTEDDLLKGMGLKLGPALKIYNHIVK 64

MBT_L3MBTL1_rpt3

cd20137

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

7.49e-22

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 90.27 E-value: 7.49e-22

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20137    5 FQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73

MBT_L3MBTL3_rpt2

cd20135

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

3.22e-21

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 89.09 E-value: 3.22e-21

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20135    6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTP 74

MBT_L3MBTL1_rpt2

cd20134

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

4.13e-21

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 88.74 E-value: 4.13e-21

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20134    6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP 74

MBT_L3MBTL3_rpt1

cd20132

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

146-217

5.41e-21

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 88.83 E-value: 5.41e-21

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011633 146 QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20132    3 KNGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74

MBT_L3MBTL3_rpt1

cd20132

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

38-137

9.06e-21

Pssm-ID: 439122 Cd Length: 101 Bit Score: 88.06 E-value: 9.06e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  38 NEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSS 117
Cdd:cd20132    4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEEFN 83

                         90       100
                 ....*....|....*....|
gi 569011633 118 WPMFLlrVLTGSELAPAVFF 137
Cdd:cd20132   84 WQSYL--KTCKAQAAPKSLF 101

MBT

cd20088

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

40-99

9.40e-21

Pssm-ID: 439080 Cd Length: 61 Bit Score: 86.54 E-value: 9.40e-21

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDN-KNDFWRLVDSSDIQPVGTCE 99
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPsRYDFWCDVDSPDIHPVGWCE 61

MBT_L3MBTL4_rpt1

cd20133

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

38-122

1.05e-20

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 87.93 E-value: 1.05e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  38 NEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSS 117
Cdd:cd20133    4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGEFN 83


                 ....*
gi 569011633 118 WPMFL 122
Cdd:cd20133   84 WSSYL 88

MBT_L3MBTL3_rpt3

cd20138

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

137-217

1.18e-20

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 86.90 E-value: 1.18e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 137 FKEEPPRPLQNNfivgMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQP 216
Cdd:cd20138    1 FKVKPPHGFQKN----MKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQP 76


                 .
gi 569011633 217 P 217
Cdd:cd20138   77 P 77

MBT_MBTD1_rpt4

cd20129

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

149-217

1.96e-20

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 86.19 E-value: 1.96e-20

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20129    3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

MBT_L3MBTL4_rpt3

cd20139

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

137-217

1.95e-19

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 83.76 E-value: 1.95e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 137 FKEEPPrplqNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQP 216
Cdd:cd20139    1 FKLRPP----HGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQV 76


                 .
gi 569011633 217 P 217
Cdd:cd20139   77 P 77

MBT_L3MBTL4_rpt1

cd20133

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

146-217

1.98e-19

Pssm-ID: 439123 Cd Length: 101 Bit Score: 84.07 E-value: 1.98e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011633 146 QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20133    3 RNGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPP 74

MBT_L3MBTL2_rpt4

cd20130

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

147-217

3.02e-19

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 82.73 E-value: 3.02e-19

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 147 NNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20130    4 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

MBT_L3MBTL1-like_rpt3

cd20103

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

36-108

1.24e-18

Pssm-ID: 439093 Cd Length: 73 Bit Score: 80.78 E-value: 1.24e-18

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633  36 PTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPP 108
Cdd:cd20103    1 PPHGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

MBT_L3MBTL1_rpt1

cd20131

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

29-137

1.77e-18

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 81.85 E-value: 1.77e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  29 FRQSKTPP--TNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQ 106
Cdd:cd20131    1 FQDSQAVThnKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQ 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569011633 107 PPLGYTLNTSSWPMFLLrvLTGSELAPAVFF 137
Cdd:cd20131   81 PPKGYKEEEFSWSQYLR--STRAQAAPKHLF 109

MBT_L3MBTL1_rpt1

cd20131

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

137-217

8.54e-18

Pssm-ID: 439121 Cd Length: 109 Bit Score: 79.92 E-value: 8.54e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 137 FKEEPPRPL-QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQ 215
Cdd:cd20131    1 FQDSQAVTHnKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQ 80


                 ..
gi 569011633 216 PP 217
Cdd:cd20131   81 PP 82

MBT_L3MBTL4_rpt2

cd20136

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

39-122

1.25e-17

Pssm-ID: 439126 Cd Length: 92 Bit Score: 78.89 E-value: 1.25e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  39 EFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGY-TLNTSS 117
Cdd:cd20136    4 EFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYpNPEKFS 83


                 ....*
gi 569011633 118 WPMFL 122
Cdd:cd20136   84 WTEYL 88

MBT_SFMBT_rpt1

cd20093

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

146-222

2.22e-17

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 78.09 E-value: 2.22e-17

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 146 QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGW--SGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVE 222
Cdd:cd20093    1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYedDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKE 79

MBT_SFMBT_rpt4

cd20096

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

149-220

3.78e-17

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 76.89 E-value: 3.78e-17

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSG-AFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKlSPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

MBT_dSfmbt_rpt4

cd20128

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

147-217

5.16e-16

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 73.53 E-value: 5.16e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 147 NNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20128    1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

MBT_SFMBT_rpt1

cd20093

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

38-128

1.31e-15

Pssm-ID: 439083 Cd Length: 94 Bit Score: 73.08 E-value: 1.31e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  38 NEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNT 115
Cdd:cd20093    2 SGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGyeDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEKE 81

                         90
                 ....*....|...
gi 569011633 116 SSWPMFLLRVLTG 128
Cdd:cd20093   82 LDWAEFLIKELTG 94

MBT_SFMBT2_rpt1

cd20112

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

40-128

1.53e-15

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 73.09 E-value: 1.53e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSS 117
Cdd:cd20112    4 FQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGygDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEKYTD 83

                         90
                 ....*....|.
gi 569011633 118 WPMFLLRVLTG 128
Cdd:cd20112   84 WTEFLIHDLTG 94

MBT_SCML2_rpt1

cd20106

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...

140-217

5.40e-15

Pssm-ID: 439096 Cd Length: 98 Bit Score: 71.49 E-value: 5.40e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633 140 EPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20106    1 QSRIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPP 78

MBT_L3MBTL1_rpt3

cd20137

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

36-110

8.21e-15

Pssm-ID: 439127 Cd Length: 75 Bit Score: 70.24 E-value: 8.21e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633  36 PTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLG 110
Cdd:cd20137    1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 75

MBT_SFMBT_rpt4

cd20096

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

40-111

1.04e-14

Pssm-ID: 439086 Cd Length: 73 Bit Score: 69.96 E-value: 1.04e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWrLVD--SSDIQPVGTCEQGGDLLQPPLGY 111
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNI-IVDveSTDIFPVGWCESNGYPLVTPRKY 73

MBT_dSfmbt-like_rpt4

cd20100

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

38-108

3.03e-14

Pssm-ID: 439090 Cd Length: 71 Bit Score: 68.47 E-value: 3.03e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633  38 NEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPP 108
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

117-217

3.38e-14

Pssm-ID: 439095 Cd Length: 131 Bit Score: 70.41 E-value: 3.38e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 117 SWPMFLLRvlTGSELAPAVFFKEEPPRPLqNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDY 196
Cdd:cd20105    3 SWDKYLKE--TGAVPAPVHCFKQSYTPPV-NEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLV 79

                         90       100
                 ....*....|....*....|.
gi 569011633 197 DSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20105   80 DSSEIQPIGNCEKNGGMLQPP 100

MBT_L3MBTL4_rpt3

cd20139

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

33-112

6.82e-14

Pssm-ID: 439129 Cd Length: 82 Bit Score: 67.97 E-value: 6.82e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  33 KTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYT 112
Cdd:cd20139    2 KLRPPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGAS 81

MBT_dSfmbt-like_rpt2

cd20098

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

39-102

1.70e-13

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 66.50 E-value: 1.70e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569011633  39 EFKIGMKLEARDPRNIDSVCVASVIGITGARLRLR-LDGSDNKNDFWRLVDSSDIQPVGTCEQGG 102
Cdd:cd20098   14 PFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVG 78

MBT_dScm_rpt1

cd20107

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...

139-217

3.75e-13

Pssm-ID: 439097 Cd Length: 99 Bit Score: 66.10 E-value: 3.75e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 139 EEPPRplqNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20107    3 QNPPK---NEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPP 78

MBT_SFMBT2_rpt1

cd20112

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

146-222

3.82e-13

Pssm-ID: 439102 Cd Length: 94 Bit Score: 66.16 E-value: 3.82e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 146 QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSG--AFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVE 222
Cdd:cd20112    1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDdrRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKE 79

MBT_SFMBT1_rpt1

cd20111

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

38-128

3.89e-13

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 66.01 E-value: 3.89e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  38 NEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNT 115
Cdd:cd20111    2 NGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGygEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDKL 81

                         90
                 ....*....|...
gi 569011633 116 SSWPMFLLRVLTG 128
Cdd:cd20111   82 SDWEEFLAQTLTG 94

MBT_L3MBTL3_rpt2

cd20135

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

40-122

4.78e-13

Pssm-ID: 439125 Cd Length: 93 Bit Score: 65.59 E-value: 4.78e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYT-LNTSSW 118
Cdd:cd20135    6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKdPKHFSW 85


                 ....
gi 569011633 119 PMFL 122
Cdd:cd20135   86 EKYL 89

MBT_dSfmbt-like_rpt2

cd20098

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

149-211

7.36e-13

Pssm-ID: 439088 Cd Length: 83 Bit Score: 64.96 E-value: 7.36e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHIT-FDGWSGAFDYWCDYDSRDIFPVGWCRLTG 211
Cdd:cd20098   15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVG 78

MBT_L3MBTL3_rpt3

cd20138

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

32-109

8.07e-13

Pssm-ID: 439128 Cd Length: 78 Bit Score: 64.56 E-value: 8.07e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633  32 SKTPPTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20138    1 FKVKPPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQPPL 78

SAM_Scm-like-4MBT1,2

cd09581

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

923-991

9.81e-13

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.

Pssm-ID: 188980 Cd Length: 85 Bit Score: 64.78 E-value: 9.81e-13

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 923 DPSTWSVDEVIQFMKHTDpqiSGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLK 991
Cdd:cd09581   11 NPLFWSVDDVVRFIKSTD---CAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVK 76

SAM_Ph1,2,3

cd09577

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain ...

922-992

9.82e-13

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.

Pssm-ID: 188976 Cd Length: 69 Bit Score: 63.96 E-value: 9.82e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633 922 KDPSTWSVDEVIQFMKHTdPQISGpLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKE 992
Cdd:cd09577    1 SNPSKWSVEDVYEFIRSL-PGCSD-YAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICAKINSLKE 69

MBT_MBTD1_rpt4

cd20129

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

40-108

2.52e-12

Pssm-ID: 439119 Cd Length: 71 Bit Score: 63.07 E-value: 2.52e-12

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPP 108
Cdd:cd20129    3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

MBT_L3MBTL1_rpt2

cd20134

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

40-111

2.65e-12

Pssm-ID: 439124 Cd Length: 93 Bit Score: 63.70 E-value: 2.65e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGY 111
Cdd:cd20134    6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDY 77

MBT_dSfmbt-like_rpt3

cd20099

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

40-122

4.78e-12

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 62.70 E-value: 4.78e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITgaR---LRLRLDGSDNK---NDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTL 113
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVL--RfgyLVIGIDGPSADdgsDWFCCHASSPFIFPVGFAEKNGIELTPPRGYES 78


                 ....*....
gi 569011633 114 NTSSWPMFL 122
Cdd:cd20099   79 KPFDWEEYL 87

MBT_SFMBT1_rpt1

cd20111

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

146-222

6.63e-12

Pssm-ID: 439101 Cd Length: 94 Bit Score: 62.54 E-value: 6.63e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 146 QNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSG--AFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVE 222
Cdd:cd20111    1 QNGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEdrRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRD 79

MBT_L3MBTL2_rpt4

cd20130

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

36-109

9.00e-12

Pssm-ID: 439120 Cd Length: 75 Bit Score: 61.54 E-value: 9.00e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633  36 PTNEFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20130    2 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPV 75

MBT_SFMBT2_rpt4

cd20118

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

149-221

2.86e-11

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 60.61 E-value: 2.86e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAF-DYWCDYDSRDIFPVGWCRLTGDVLQPPGKIV 221
Cdd:cd20118    2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPPHKAV 75

SAM_Scm-like-3MBT3,4

cd09582

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

924-983

6.28e-11

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.

Pssm-ID: 188981 Cd Length: 66 Bit Score: 58.83 E-value: 6.28e-11

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 924 PSTWSVDEVIQFMkHTDPQiSGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKL 983
Cdd:cd09582    1 VLRWSVDEVAEFV-QSLPG-CEEHAKVFRDEQIDGEAFLLLTQSDLVKILGIKLGPALKI 58

MBT_L3MBTL2_rpt3

cd20127

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

40-122

6.93e-11

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 59.46 E-value: 6.93e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASV----------IGITGARLRlrlDGSDNkndFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20127    1 FEEGMKLEAIDPLNLGNICVATVckvlldgylmIGIDGGPST---DGSDW---FCYHASSHAIFPVGFCQKNDIELTPPK 74

                         90
                 ....*....|...
gi 569011633 110 GYTLNTSSWPMFL 122
Cdd:cd20127   75 GYDAQTFNWENYL 87

MBT_MBTD1_rpt3

cd20126

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

40-112

7.28e-11

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 59.42 E-value: 7.28e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASV----------IGITGArlrLRLDGSDNkndFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20126    1 FKEGMKLEAIDPLNLSTICVATVrkvlangylmIGIDGS---EAADGSDW---FCYHATSPSIFPVGFCEINMIELTPPR 74


                 ...
gi 569011633 110 GYT 112
Cdd:cd20126   75 GYK 77

MBT_SFMBT2_rpt4

cd20118

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

40-109

9.95e-11

Pssm-ID: 439108 Cd Length: 91 Bit Score: 59.07 E-value: 9.95e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKN-DFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20118    2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPPH 72

MBT_dSfmbt_rpt1

cd20119

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

42-133

7.09e-10

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 57.07 E-value: 7.09e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  42 IGMKLE-----ARDPRNIDSVCVASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLN 114
Cdd:cd20119    6 VGMKVEventdTDLIEDPTSFWIATVLKIAGYKALMRYEGfgTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIEHK 85

                         90
                 ....*....|....*....
gi 569011633 115 TSSWPMFLLRVLTGSELAP 133
Cdd:cd20119   86 YSDWKEFLVKRLTGARTLP 104

MBT_dSfmbt_rpt3

cd20125

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

40-142

7.29e-10

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 57.17 E-value: 7.29e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGI-TGARLRLRLDGSDNKND----FWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLN 114
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRIDSYEPDASgsdwFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                         90       100
                 ....*....|....*....|....*...
gi 569011633 115 TSSWPMFLLRvlTGSELAPAVFFKEEPP 142
Cdd:cd20125   81 TFTWEGYLRQ--TGATAAPQHLFHRIIP 106

MBT_dSfmbt-like_rpt1

cd20097

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

41-133

1.17e-09

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 56.55 E-value: 1.17e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  41 KIGMKLEAR---DPRNIDSVCV---ASVIGITGARLRLRLDGSD--NKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYT 112
Cdd:cd20097    5 KIGVKVEVAnrdDDKPTDNVKVywfARIIKVAGYRVLLRYEGYDedSSHDFWINLCSNEIHPIGYAAENGKILVPPKSIE 84

                         90       100
                 ....*....|....*....|.
gi 569011633 113 LNTSSWPMFLLRVLTGSELAP 133
Cdd:cd20097   85 DKENDWKEYIMKRLHGKRTIP 105

SAM_Atherin-like

cd09583

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin ...

924-995

1.25e-09

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.

Pssm-ID: 188982 Cd Length: 69 Bit Score: 55.35 E-value: 1.25e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 924 PSTWSVDEVIQFMKHTD-PQisgpLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKEINH 995
Cdd:cd09583    1 PSNWSVEDVVQYFKTAGfPE----EANAFKEQEIDGKSLLLLTRSDVLTGLSLKLGPALKIYEHVVKLQQQSH 69

MBT_dSfmbt-like_rpt3

cd20099

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

149-217

1.58e-09

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 55.77 E-value: 1.58e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQ-LHITFDG---WSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGyLVIGIDGpsaDDGSDWFCCHASSPFIFPVGFAEKNGIELTPP 73

SAM_Scm-like-4MBT

cd09580

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

924-991

2.19e-09

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT (Sex comb on midleg like, Malignant Brain Tumor) subfamily proteins of the polycomb group is a putative protein-protein interaction domain. Additionally to the SAM domain, most of the proteins of this subfamily have 4 MBT repeats. In Drosophila SAM-Scm-like-4MBT protein (known as dSfmbt) is a member of Pho repressive complex (PhoRC). Additionally to dSfmbt, the PhoRC complex includes Pho or Pho-like proteins. This complex is responsible for HOX (Homeobox) gene silencing: Pho or Pho-like proteins bind DNA and dSmbt binds methylated histones. dSmbt can interact with mono- and di-methylated histones H3 and H4 (however this activity has been shown for the MBT repeats, while exact function of the SAM domain is unclear). Besides interaction with histones, dSmbt can interact with Scm (a member of PRC complex), but this interaction also seems to be SAM domain independent.

Pssm-ID: 188979 Cd Length: 67 Bit Score: 54.30 E-value: 2.19e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633 924 PSTWSVDEVIQFMKHTDpqiSGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLK 991
Cdd:cd09580    1 PSTWGVKDVSQFLREND---CGAYCECFCRQNIDGKRLLSLTKEQIMTLTGMKVGPSLKIYDLIQQLK 65

MBT_MBTD1_rpt1

cd20120

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

59-133

2.57e-09

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 55.63 E-value: 2.57e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011633  59 VASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSSWPMFLLRVLTGSELAP 133
Cdd:cd20120   26 IAGIVKLAGYKALLRYEGfeNDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQHKYTNWKAFLVKRLTGAKTLP 102

MBT_SFMBT_rpt3

cd20095

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

149-221

4.35e-09

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 54.57 E-value: 4.35e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQ-LHITFD----GWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIV 221
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYyFLVEIDdlrpEESEKITFVCHANSPGIFPVGWCAKNGLRLTPPPGYP 78

MBT_SFMBT_rpt2

cd20094

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

40-122

4.94e-09

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 54.16 E-value: 4.94e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKN--DFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTL--NT 115
Cdd:cd20094    4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSDspDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLEKlhAT 83


                 ....*..
gi 569011633 116 SSWPMFL 122
Cdd:cd20094   84 EEWKAIL 90

MBT_SFMBT1_rpt4

cd20117

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

39-108

6.24e-09

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 54.12 E-value: 6.24e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569011633  39 EFKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPVGTCEQGGDLLQPP 108
Cdd:cd20117    2 CFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPiPECIVHVESMDIFPVGWCETNGYPLLHP 72

MBT_SFMBT2_rpt3

cd20116

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

149-217

1.05e-08

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 53.27 E-value: 1.05e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQ-LHITFDGWSGAFD---YWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20116    3 FTVGMKLEVVDPREPFHICPASVTKVFNNHyFQVTVDDLRPEASensMLCHADSLGILPVQWCLKNGVNLTPP 75

MBT_SFMBT_rpt3

cd20095

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

40-122

2.44e-08

Pssm-ID: 439085 Cd Length: 92 Bit Score: 52.26 E-value: 2.44e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRL----RLDGSDNKNDfwRLV---DSSDIQPVGTCEQGGDLLQPPLGYT 112
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLveidDLRPEESEKI--TFVchaNSPGIFPVGWCAKNGLRLTPPPGYP 78

                         90
                 ....*....|
gi 569011633 113 LNTSSWPMFL 122
Cdd:cd20095   79 KSEFDWDSYL 88

MBT_dSfmbt_rpt2

cd20122

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

145-211

3.98e-08

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 51.38 E-value: 3.98e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633 145 LQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFD-YWCDYDSRDIFPVGWCRLTG 211
Cdd:cd20122   10 LRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDgFWCHEDSPLIHPVGWAQTVG 77

MBT_dSfmbt_rpt2

cd20122

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

40-96

5.24e-08

Pssm-ID: 439112 Cd Length: 83 Bit Score: 51.00 E-value: 5.24e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKND-FWRLVDSSDIQPVG 96
Cdd:cd20122   14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDgFWCHEDSPLIHPVG 71

MBT_MBTD1_rpt3

cd20126

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

149-217

5.32e-08

Pssm-ID: 439116 Cd Length: 90 Bit Score: 51.33 E-value: 5.32e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQ-LHITFDGWSGA--FDYWCDY-DSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20126    1 FKEGMKLEAIDPLNLSTICVATVRKVLANGyLMIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 73

PTZ00121

MAEBL; Provisional

263-602

1.50e-07

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 55.92 E-value: 1.50e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  263 DENRTLKDCRgEAAEEPGTSAFTFGDENRtlKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPrgrgftqpleD 342
Cdd:PTZ00121 1209 EEERKAEEAR-KAEDAKKAEAVKKAEEAK--KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA----------E 1275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  343 EARPGRDVQvaPAEKKRKGKTVTTpwTEDPRLfADQGDAPAEKKRKGKTVTTPwTEDPRLFADQGDAPAEKKRKGktvtt 422
Cdd:PTZ00121 1276 EARKADELK--KAEEKKKADEAKK--AEEKKK-ADEAKKKAEEAKKADEAKKK-AEEAKKKADAAKKKAEEAKKA----- 1344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  423 pwTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLF------------ADQ 490
Cdd:PTZ00121 1345 --AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAdelkkaaaakkkADE 1422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  491 GDAPAEKKRKGKTVTTPWTEDPRlfADQGAAPAEKKRKGKTVTTPWTEDPRlfADQGDAPAEKKRKGKTVTTPwTEDPRL 570
Cdd:PTZ00121 1423 AKKKAEEKKKADEAKKKAEEAKK--ADEAKKKAEEAKKAEEAKKKAEEAKK--ADEAKKKAEEAKKADEAKKK-AEEAKK 1497

                         330       340       350
                  ....*....|....*....|....*....|..
gi 569011633  571 FADQGDAPAEKKpkgKRVTKSRKDQAQFLADE 602
Cdd:PTZ00121 1498 KADEAKKAAEAK---KKADEAKKAEEAKKADE 1526

MBT_L3MBTL2_rpt1

cd20121

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

43-133

1.53e-07

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 50.23 E-value: 1.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  43 GMKLEARdprNIDSVC------VASVIGITGARLRLRLDG--SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLN 114
Cdd:cd20121    7 GMKVEVL---NTDAVLpsrvywIASVIQLAGYKALLRYEGfeNDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTIHAK 83

                         90
                 ....*....|....*....
gi 569011633 115 TSSWPMFLLRVLTGSELAP 133
Cdd:cd20121   84 FTDWRGYLMKRLVGSRTIP 102

SAM_1

pfam00536

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...

925-991

2.07e-07

Pssm-ID: 425739 Cd Length: 64 Bit Score: 48.80 E-value: 2.07e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011633  925 STWSVDEVIQFMKHTDPqisGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLK 991
Cdd:pfam00536   1 DGWSVEDVGEWLESIGL---GQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64

MBT_SFMBT1_rpt3

cd20115

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

149-217

3.17e-07

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 49.09 E-value: 3.17e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITF-----DGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20115    3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEmddlrPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPP 76

MBT_dSfmbt_rpt4

cd20128

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

40-98

3.48e-07

Pssm-ID: 439118 Cd Length: 72 Bit Score: 48.50 E-value: 3.48e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTC 98
Cdd:cd20128    3 FEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWC 61

SAM

smart00454

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...

924-992

3.77e-07

Pssm-ID: 197735 Cd Length: 68 Bit Score: 48.06 E-value: 3.77e-07

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633   924 PSTWSVDEVIQFMKHTDPQisgPLADLFRQHEIDGKALLLLKSELLMKYMG-LKLGPAVKLCYYIEKLKE 992
Cdd:smart00454   1 VSQWSPESVADWLESIGLE---QYADNFRKNGIDGALLLLLTSEEDLKELGiTKLGHRKKILKAIQKLKE 67

MBT_SFMBT1_rpt4

cd20117

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

153-219

4.90e-07

Pssm-ID: 439107 Cd Length: 90 Bit Score: 48.72 E-value: 4.90e-07

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633 153 MKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAF-DYWCDYDSRDIFPVGWCRLTGDVLQPPGK 219
Cdd:cd20117    7 MKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIpECIVHVESMDIFPVGWCETNGYPLLHPRK 74

MBT_SFMBT_rpt2

cd20094

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

151-220

9.50e-07

Pssm-ID: 439084 Cd Length: 91 Bit Score: 47.61 E-value: 9.50e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569011633 151 VGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGW--SGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20094    6 VGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPedSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKSL 77

MBT_dSfmbt_rpt3

cd20125

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

149-217

1.02e-06

Pssm-ID: 439115 Cd Length: 107 Bit Score: 48.31 E-value: 1.02e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVC-GDQLHITFDGW---SGAFDYWCDYDSRD-IFPVGWCRLTGDVLQPP 217
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVLrFGYLMIRIDSYepdASGSDWFCYHESSPcIFPAGFCEVNNITLTPP 74

MBT_L3MBTL2_rpt2

cd20124

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

40-108

1.09e-05

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 44.44 E-value: 1.09e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPP 108
Cdd:cd20124   14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

SAM_Samd7,11

cd09579

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a ...

925-983

2.74e-05

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.

Pssm-ID: 188978 Cd Length: 68 Bit Score: 42.82 E-value: 2.74e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 925 STWSVDEVIQFMKHTDpqISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKL 983
Cdd:cd09579    2 RKWTVDDVCSFIGSLP--GCAEYAQVFREHSIDGETLPLLTEEHLLNTMGLKLGPALKI 58

MBT_PHF20L1-like

cd20104

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and ...

149-205

3.49e-05

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains; PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439094 [Multi-domain] Cd Length: 60 Bit Score: 42.23 E-value: 3.49e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNpfMICPATIGAV--CGDQLHITFDGWSGAFDYWCDYDSRDIFPVG 205
Cdd:cd20104    1 FKVGDRVDALDGEG--KWYEAKIVEVdeEENKVLVHYDGWSSRYDEWIDRDSERLRPLH 57

MBT_SFMBT1_rpt2

cd20113

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

43-109

7.96e-05

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 42.49 E-value: 7.96e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633  43 GMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSD--NKNDFWRLVDSSDIQPVGTCEQGGDLLQPPL 109
Cdd:cd20113    7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEgsDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPA 75

MBT_dSfmbt_rpt1

cd20119

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

148-220

8.69e-05

Pssm-ID: 439109 Cd Length: 104 Bit Score: 42.43 E-value: 8.69e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633 148 NFIVGMKIEAVDR-----KNPFMICPATIGAVCGDQLHITFDGWSG--AFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20119    3 NITVGMKVEVENTdtdliEDPTSFWIATVLKIAGYKALMRYEGFGTddSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTI 82

MBT_L3MBTL2_rpt2

cd20124

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

1.16e-04

Pssm-ID: 439114 Cd Length: 84 Bit Score: 41.75 E-value: 1.16e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20124   14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

MBT_L3MBTL2_rpt1

cd20121

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

150-220

3.28e-04

Pssm-ID: 439111 Cd Length: 102 Bit Score: 40.98 E-value: 3.28e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569011633 150 IVGMKIEAVdrkNPFMICP------ATIGAVCGDQLHITFDGW--SGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20121    5 MEGMKVEVL---NTDAVLPsrvywiASVIQLAGYKALLRYEGFenDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTI 80

MBT_L3MBTL2_rpt3

cd20127

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

149-217

3.63e-04

Pssm-ID: 439117 Cd Length: 91 Bit Score: 40.58 E-value: 3.63e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569011633 149 FIVGMKIEAVDRKNPFMICPATIGAVCGD-QLHITFDGWSGA--FDYWCDY-DSRDIFPVGWCRLTGDVLQPP 217
Cdd:cd20127    1 FEEGMKLEAIDPLNLGNICVATVCKVLLDgYLMIGIDGGPSTdgSDWFCYHaSSHAIFPVGFCQKNDIELTPP 73

PTZ00121

MAEBL; Provisional

341-528

3.71e-04

MAEBL; Provisional

Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.75 E-value: 3.71e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  341 EDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPwTEDPRLFADQGDAPAEKKRKGKTV 420
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEEL 1652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  421 TTPwTEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRlfadqgdaPAEKKRK 500
Cdd:PTZ00121 1653 KKA-EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK--------KAEELKK 1723

                         170       180
                  ....*....|....*....|....*...
gi 569011633  501 GKTVTTPWTEDPRLFADQGAAPAEKKRK 528
Cdd:PTZ00121 1724 AEEENKIKAEEAKKEAEEDKKKAEEAKK 1751

MBT_MBTD1_rpt1

cd20120

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

151-220

4.03e-04

Pssm-ID: 439110 Cd Length: 103 Bit Score: 40.60 E-value: 4.03e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011633 151 VGMKIEAVDRKNP-----FMIcpATIGAVCGDQLHITFDGW--SGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20120    6 EGVRVEVPNTDCNlptkvFWI--AGIVKLAGYKALLRYEGFenDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTI 80

MBT_MBTD1_rpt2

cd20123

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

40-96

9.66e-04

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 39.17 E-value: 9.66e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPVG 96
Cdd:cd20123   14 FKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESEDGtDDFWCHMYSPLIHHIG 71

MBT_SFMBT2_rpt3

cd20116

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

40-118

1.98e-03

Pssm-ID: 439106 Cd Length: 93 Bit Score: 38.63 E-value: 1.98e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  40 FKIGMKLEARDPRNIDSVCVASVIGITGARL------RLRLDGSdnKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTL 113
Cdd:cd20116    3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYfqvtvdDLRPEAS--ENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80


                 ....*
gi 569011633 114 NTSSW 118
Cdd:cd20116   81 QDFDW 85

MBT_MBTD1_rpt2

cd20123

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

137-211

2.26e-03

Pssm-ID: 439113 Cd Length: 85 Bit Score: 38.01 E-value: 2.26e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569011633 137 FKEEPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFD-GWSGAFDYWCDYDSRDIFPVGWCRLTG 211
Cdd:cd20123    2 FSQKVSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEeSEDGTDDFWCHMYSPLIHHIGWSRSIG 77

MBT_dSfmbt-like_rpt1

cd20097

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

152-220

3.49e-03

Pssm-ID: 439087 Cd Length: 105 Bit Score: 38.06 E-value: 3.49e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569011633 152 GMKIEAVDRKNPFMIC------PATIGAVCGDQLHITFDGW--SGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKI 220
Cdd:cd20097    7 GVKVEVANRDDDKPTDnvkvywFARIIKVAGYRVLLRYEGYdeDSSHDFWINLCSNEIHPIGYAAENGKILVPPKSI 83

PTZ00108

DNA topoisomerase 2-like protein; Provisional

500-678

3.67e-03

DNA topoisomerase 2-like protein; Provisional

Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 41.57 E-value: 3.67e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  500 KGKTVTTPWTED----PRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQG 575
Cdd:PTZ00108 1122 KNTTPKDMWLEDldkfEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRV 1201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  576 DAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALFSALSVSSTERTPPSSSEQPKSSTSGKTKSTSRGAQTSRKSPRKTSV 655
Cdd:PTZ00108 1202 DSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAV 1281

                         170       180
                  ....*....|....*....|...
gi 569011633  656 VQPVPKTSKKAGKSKSTGNTSSP 678
Cdd:PTZ00108 1282 QYSPPPPSKRPDGESNGGSKPSS 1304

MBT_SFMBT2_rpt2

cd20114

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

46-130

5.89e-03

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 37.40 E-value: 5.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011633  46 LEARDPRNIDSVCVASVIGITGARLRLRLDG-SDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLG-YTLNTSS-WPMFL 122
Cdd:cd20114   10 IELQDSQNPFQYWIVRVIENVGGRLRLRYVGlEDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEiCDLKSASeWKEAL 89


                 ....*...
gi 569011633 123 LRVLTGSE 130
Cdd:cd20114   90 EKSLAEAA 97

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01