NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|569008730|ref|XP_006527676|]
View 

nyctalopin isoform X1 [Mus musculus]

Protein Classification

LRR and LRRCT domain-containing protein( domain architecture ID 12020582)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-326 2.75e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 2.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  69 LRILGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgELRYLHvRTFAALGRLRRLDLAACRLFSVPEr 148
Cdd:COG4886  101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 149 LLAELPALRELTAFDNLFRRVPGALRGLANLThahfersrieavasgsllgmrrlrSLSLQANRVRavhagafgdcgale 228
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE------------------------ELDLSGNQLT-------------- 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 229 dlllndnllaTLPAAaFRGLRRLRTLNLGGNALGSVAraWFSDLAELELLYLDRNSITFVEEGAfqNLSGLLALHLNGNR 308
Cdd:COG4886  219 ----------DLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                        250
                 ....*....|....*...
gi 569008730 309 LTVLSWAAFQPGFFLGRL 326
Cdd:COG4886  284 LTDLKLKELELLLGLNSL 301
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-366 7.23e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 7.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008730   331 NPWRCDCQLEWLRDWMEGSGRVADVA---CASPGSVAGQ 366
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRGP 39
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 25-56 5.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 569008730   25 ACPAACTCSHvergCSVRCDRAGLQRVPQEFP 56
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-326 2.75e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 2.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  69 LRILGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgELRYLHvRTFAALGRLRRLDLAACRLFSVPEr 148
Cdd:COG4886  101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 149 LLAELPALRELTAFDNLFRRVPGALRGLANLThahfersrieavasgsllgmrrlrSLSLQANRVRavhagafgdcgale 228
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE------------------------ELDLSGNQLT-------------- 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 229 dlllndnllaTLPAAaFRGLRRLRTLNLGGNALGSVAraWFSDLAELELLYLDRNSITFVEEGAfqNLSGLLALHLNGNR 308
Cdd:COG4886  219 ----------DLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                        250
                 ....*....|....*...
gi 569008730 309 LTVLSWAAFQPGFFLGRL 326
Cdd:COG4886  284 LTDLKLKELELLLGLNSL 301
LRR_8 pfam13855
Leucine rich repeat;
249-309 2.59e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 2.59e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569008730  249 RRLRTLNLGGNALGSVARAWFSDLAELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRL 309
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 68-312 7.20e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 7.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  68 GLRILGErAFGTLPSLRRLSLRHNNLSFITPGAFKGL---PRLAELRLAHNGeLRYLHVRTFA-ALG----RLRRLDLAA 139
Cdd:cd00116   69 GLQSLLQ-GLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNG-LGDRGLRLLAkGLKdlppALEKLVLGR 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 140 CRLFSVP-ERLLAELPA---LRELTAFDNLFrRVPGA---LRGLANLTHAHFER------SRIEAVA-SGSLLGMRRLRS 205
Cdd:cd00116  147 NRLEGAScEALAKALRAnrdLKELNLANNGI-GDAGIralAEGLKANCNLEVLDlnnnglTDEGASAlAETLASLKSLEV 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 206 LSLQANRVRAVHAgafgdcgaledlllndnllATLPAAAFRGLRRLRTLNLGGNALGSVArawFSDLAEL-----ELLYL 280
Cdd:cd00116  226 LNLGDNNLTDAGA-------------------AALASALLSPNISLLTLSLSCNDITDDG---AKDLAEVlaekeSLLEL 283

                        250       260       270
                 ....*....|....*....|....*....|..
gi 569008730 281 DRNSITFVEEGAFqnLSGLLaLHLNGNRLTVL 312
Cdd:cd00116  284 DLRGNKFGEEGAQ--LLAES-LLEPGNELESL 312
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-366 7.23e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 7.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008730   331 NPWRCDCQLEWLRDWMEGSGRVADVA---CASPGSVAGQ 366
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRGP 39
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 280-395 1.99e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.85  E-value: 1.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730   280 LDRNSITFVEEGAFQNLSGLLALHLNGNrltvlswaafqpgfflgrlflfrnPWRCDCQLEWLRDWMEGSG----RVADV 355
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGN------------------------PFECDCGLARLPRWAEEKGvkvrQPEAA 57

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 569008730   356 ACASPGSVAGQDLSQVVF--------------ERSSDGLCVDPDELNFTTSSPG 395
Cdd:TIGR00864   58 LCAGPGALAGQPLLGIPLldsgcdeeyvaclkDNSSGGGAARSELVIFSAAHEG 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-310 6.36e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 6.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  61 SIDLDRNGLRI-LGERAFGTLPSLRRLSLRHNNLSFITPGAFkgLPRLAELRLAHN---GELrYLHVRTFAalgRLRRLD 136
Cdd:PLN00113  97 TINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNmlsGEI-PNDIGSFS---SLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 137 LAACRLFSVPERLLAELPALRELT-AFDNLFRRVPGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRVRA 215
Cdd:PLN00113 171 LGGNVLVGKIPNSLTNLTSLEFLTlASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 216 VHAGAFGDCGALEDLLLNDNLLA-TLPAAAFrGLRRLRTLNLGGNALGSVARAWFSDLAELELLYLDRNSITFVEEGAFQ 294
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT 329

                        250
                 ....*....|....*.
gi 569008730 295 NLSGLLALHLNGNRLT 310
Cdd:PLN00113 330 SLPRLQVLQLWSNKFS 345
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 25-56 5.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 569008730   25 ACPAACTCSHvergCSVRCDRAGLQRVPQEFP 56
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-56 1.16e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569008730    25 ACPAACTCSHvergCSVRCDRAGLQRVPQEFP 56
Cdd:smart00013   1 ACPAPCNCSG----TAVDCSGRGLTEVPLDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
80-103 1.99e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....
gi 569008730    80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-326 2.75e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 2.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  69 LRILGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgELRYLHvRTFAALGRLRRLDLAACRLFSVPEr 148
Cdd:COG4886  101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 149 LLAELPALRELTAFDNLFRRVPGALRGLANLThahfersrieavasgsllgmrrlrSLSLQANRVRavhagafgdcgale 228
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE------------------------ELDLSGNQLT-------------- 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 229 dlllndnllaTLPAAaFRGLRRLRTLNLGGNALGSVAraWFSDLAELELLYLDRNSITFVEEGAfqNLSGLLALHLNGNR 308
Cdd:COG4886  219 ----------DLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                        250
                 ....*....|....*...
gi 569008730 309 LTVLSWAAFQPGFFLGRL 326
Cdd:COG4886  284 LTDLKLKELELLLGLNSL 301
LRR_8 pfam13855
Leucine rich repeat;
249-309 2.59e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 2.59e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569008730  249 RRLRTLNLGGNALGSVARAWFSDLAELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRL 309
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-115 7.91e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 7.91e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569008730   61 SIDLDRNGLRILGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 115
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
81-142 1.66e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.66e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569008730   81 PSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNgELRYLHVRTFAALGRLRRLDLAACRL 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
201-285 1.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  201 RRLRSLSLQANRVRAVHAGAFgdcgaledlllndnllatlpaaafRGLRRLRTLNLGGNALGSVARAWFSDLAELELLYL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAF------------------------KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 569008730  281 DRNSI 285
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
274-318 1.98e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569008730  274 ELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRLTVLSWAAFQ 318
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 68-312 7.20e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 7.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  68 GLRILGErAFGTLPSLRRLSLRHNNLSFITPGAFKGL---PRLAELRLAHNGeLRYLHVRTFA-ALG----RLRRLDLAA 139
Cdd:cd00116   69 GLQSLLQ-GLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNG-LGDRGLRLLAkGLKdlppALEKLVLGR 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 140 CRLFSVP-ERLLAELPA---LRELTAFDNLFrRVPGA---LRGLANLTHAHFER------SRIEAVA-SGSLLGMRRLRS 205
Cdd:cd00116  147 NRLEGAScEALAKALRAnrdLKELNLANNGI-GDAGIralAEGLKANCNLEVLDlnnnglTDEGASAlAETLASLKSLEV 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 206 LSLQANRVRAVHAgafgdcgaledlllndnllATLPAAAFRGLRRLRTLNLGGNALGSVArawFSDLAEL-----ELLYL 280
Cdd:cd00116  226 LNLGDNNLTDAGA-------------------AALASALLSPNISLLTLSLSCNDITDDG---AKDLAEVlaekeSLLEL 283

                        250       260       270
                 ....*....|....*....|....*....|..
gi 569008730 281 DRNSITFVEEGAFqnLSGLLaLHLNGNRLTVL 312
Cdd:cd00116  284 DLRGNKFGEEGAQ--LLAES-LLEPGNELESL 312
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-366 7.23e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 7.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008730   331 NPWRCDCQLEWLRDWMEGSGRVADVA---CASPGSVAGQ 366
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRGP 39
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 280-395 1.99e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 50.85  E-value: 1.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730   280 LDRNSITFVEEGAFQNLSGLLALHLNGNrltvlswaafqpgfflgrlflfrnPWRCDCQLEWLRDWMEGSG----RVADV 355
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGN------------------------PFECDCGLARLPRWAEEKGvkvrQPEAA 57

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 569008730   356 ACASPGSVAGQDLSQVVF--------------ERSSDGLCVDPDELNFTTSSPG 395
Cdd:TIGR00864   58 LCAGPGALAGQPLLGIPLldsgcdeeyvaclkDNSSGGGAARSELVIFSAAHEG 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-310 6.36e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 6.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  61 SIDLDRNGLRI-LGERAFGTLPSLRRLSLRHNNLSFITPGAFkgLPRLAELRLAHN---GELrYLHVRTFAalgRLRRLD 136
Cdd:PLN00113  97 TINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNmlsGEI-PNDIGSFS---SLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 137 LAACRLFSVPERLLAELPALRELT-AFDNLFRRVPGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRVRA 215
Cdd:PLN00113 171 LGGNVLVGKIPNSLTNLTSLEFLTlASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 216 VHAGAFGDCGALEDLLLNDNLLA-TLPAAAFrGLRRLRTLNLGGNALGSVARAWFSDLAELELLYLDRNSITFVEEGAFQ 294
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT 329

                        250
                 ....*....|....*.
gi 569008730 295 NLSGLLALHLNGNRLT 310
Cdd:PLN00113 330 SLPRLQVLQLWSNKFS 345
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-173 1.43e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.30  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730  41 VRCDRAGLQRVPQEFPCEAASIDLDRNGLRILGERAFGtlpSLRRLSLRHNNLSFITpgafKGLP-RLAELRLAHNgELR 119
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIP----ATLPdTIQEMELSIN-RIT 254

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569008730 120 YLHVRTFAAlgrLRRLDLAACRLFSVPERLLAElpaLRELTAFDNLFRRVPGAL 173
Cdd:PRK15370 255 ELPERLPSA---LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHL 302
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 81-121 3.44e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 3.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569008730   81 PSLRRLSLRHNNLSFITPgaFKGLPRLAELRLAHNGELRYL 121
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDL 39
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 25-56 5.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 569008730   25 ACPAACTCSHvergCSVRCDRAGLQRVPQEFP 56
Cdd:pfam01462   1 ACPVPCHCSA----TVVNCSDRGLTAVPRDLP 28
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 144-320 8.65e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 144 SVPERLLAELPALRELTAFDNlfRRVPGALRGLANLTHAHFER-SRIEAVASGS----LLGMRRLRSLSLQANRVRAVHA 218
Cdd:COG5238  138 PRRINLIQVLKDPLGGNAVHL--LGLAARLGLLAAISMAKALQnNSVETVYLGCnqigDEGIEELAEALTQNTTVTTLWL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008730 219 G--AFGDCGALEDlllndnllatlpAAAFRGLRRLRTLNLGGNALGSvarAWFSDLAE-------LELLYLDRNSITfvE 289
Cdd:COG5238  216 KrnPIGDEGAEIL------------AEALKGNKSLTTLDLSNNQIGD---EGVIALAEalknnttVETLYLSGNQIG--A 278

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569008730 290 EGA------FQNLSGLLALHLNGNRLTVLSWAAFQPG 320
Cdd:COG5238  279 EGAialakaLQGNTTLTSLDLSVNRIGDEGAIALAEG 315
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-56 1.16e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569008730    25 ACPAACTCSHvergCSVRCDRAGLQRVPQEFP 56
Cdd:smart00013   1 ACPAPCNCSG----TAVDCSGRGLTEVPLDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
80-103 1.99e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....
gi 569008730    80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
80-103 1.99e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....
gi 569008730    80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
61-93 2.28e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569008730   61 SIDLDRNGLRILGERAFGTLPSLRRLSLRHNNL 93
Cdd:pfam13855  29 VLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-137 8.77e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 8.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569008730  81 PSLRRLSLRHNNLSFITPgaFKGLPRLAELRLAHNgELRYLH--VRTFAALGRLRRLDL 137
Cdd:cd21340  120 NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN-QISDLEelLDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
154-213 9.60e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 9.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569008730  154 PALRELTAFDNLFRRV-PGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRV 213
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH