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Conserved domains on  [gi|569007650|ref|XP_006527327|]
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interferon-induced protein with tetratricopeptide repeats 3-like isoform X1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138577)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-362 1.71e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 121 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 200
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 201 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 280
Cdd:COG0457   82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 281 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 360
Cdd:COG0457  159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                 ..
gi 569007650 361 ID 362
Cdd:COG0457  239 AL 240
TPR_12 pfam13424
Tetratricopeptide repeat;
76-151 1.20e-03

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650   76 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHKDQAEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 151
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-362 1.71e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 121 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 200
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 201 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 280
Cdd:COG0457   82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 281 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 360
Cdd:COG0457  159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                 ..
gi 569007650 361 ID 362
Cdd:COG0457  239 AL 240
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 81-325 1.15e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650   81 LLAYIKHLDGESKAALECLGQAEDLRKsehKDQAEIRRLVTwgnyawIYYHMGRLSEAQAYVDKVRQvcqKFANPysmec 160
Cdd:TIGR02917 198 LKGDLLLSLGNIELALAAYRKAIALRP---NNIAVLLALAT------ILIEAGEFEEAEKHADALLK---KAPNS----- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  161 PELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLE--EKPEKQFSvDALKQAmelnPQNQYVKVLL 238
Cdd:TIGR02917 261 PLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLN-QILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  239 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS------LVMCRYRE 312
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTqlgiskLSQGDPSE 415

                         250
                  ....*....|...
gi 569007650  313 ILEQLQNKGDADS 325
Cdd:TIGR02917 416 AIADLETAAQLDP 428
TPR_12 pfam13424
Tetratricopeptide repeat;
76-151 1.20e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650   76 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHKDQAEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 151
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_12 pfam13424
Tetratricopeptide repeat;
118-189 2.59e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 2.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007650  118 RLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALE 189
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
121-362 1.71e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 121 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 200
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 201 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 280
Cdd:COG0457   82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 281 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 360
Cdd:COG0457  159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                 ..
gi 569007650 361 ID 362
Cdd:COG0457  239 AL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 94-311 1.74e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.09  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  94 AALECLGQAEDLRKSEHKDQAEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELEC-------- 165
Cdd:COG3914    2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAAllllaall 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 166 -EEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLR 244
Cdd:COG3914   82 eLAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLGEALRR 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007650 245 MGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS-LVMCRYR 311
Cdd:COG3914  159 LGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSnLLFALRQ 226
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 179-317 1.33e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 179 RAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDA 258
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDE---ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007650 259 LGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLvmcryREILEQL 317
Cdd:COG4235   78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL-----EASIAEA 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 159-294 3.26e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 159 ECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLL 238
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDE---AIVLLHEALELDPDEPEARLNL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650 239 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 294
Cdd:COG4783   79 GLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 172-323 3.69e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 3.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 172 LKCGRNERAKMCFEKALEEKPKDPECSSGMAiAMFRLEEKPEKqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEG 251
Cdd:COG2956   19 LLNGQPDKAIDLLEEALELDPETVEAHLALG-NLYRRRGEYDR--AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRA 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007650 252 ERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYslvmCRYREILEQLQNKGDA 323
Cdd:COG2956   96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY----CELAELYLEQGDYDEA 163
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 67-330 3.79e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  67 LEHLNSEEKATMYDLLAYIKHLDGESKAALECLGQAedLRKSEHKDQAEI----------RRLVTWGNYAWIYYHMGRLS 136
Cdd:COG2956   16 LNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNL--YRRRGEYDRAIRihqkllerdpDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 137 EAQAYVDKVRQVCQKFANPYS--MECPELEceegwtrlkcGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEk 214
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRllAEIYEQE----------GDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 215 qfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 294
Cdd:COG2956  163 --AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569007650 295 STVNNSPLYSLVmcryrEILEQLQNKGDADSSERRQ 330
Cdd:COG2956  241 LDPSDDLLLALA-----DLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 62-294 1.63e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  62 RVCNQLEHLNsEEKATMYDLLAYIKHLDGESKAALECLgqaEDLRKSEHKDQAEIRRLVTwgnyawIYYHMGRLSEAQAY 141
Cdd:COG2956   63 RIHQKLLERD-PDRAEALLELAQDYLKAGLLDRAEELL---EKLLELDPDDAEALRLLAE------IYEQEGDWEKAIEV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 142 VDKVRQVCQKFANPYsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDAL 221
Cdd:COG2956  133 LERLLKLGPENAHAY--------CELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE---AIAAL 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007650 222 KQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQkAAQFYKKKGNLDRAIELLGKALR 294
Cdd:COG2956  202 ERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA-LADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 220-329 1.23e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 220 ALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRStvnn 299
Cdd:COG4783   26 LLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL---- 101

                         90       100       110
                 ....*....|....*....|....*....|
gi 569007650 300 SPLYSLVMCRYREILEQLQNKGDADSSERR 329
Cdd:COG4783  102 DPEHPEAYLRLARAYRALGRPDEAIAALEK 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
76-294 1.70e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  76 ATMYDLLAYIKHLDGESKAALECLGQAEDLrksehkdqaEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANP 155
Cdd:COG0457   42 AEALYNLGLAYLRLGRYEEALADYEQALEL---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 156 YsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYVK 235
Cdd:COG0457  113 L--------YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALG 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007650 236 VLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 294
Cdd:COG0457  185 EAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQY 243
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 125-265 5.19e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 5.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 125 YAWIYYHMGRLSEAQAYVDKVRQvcqkfANPYSmecPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIA 204
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALE-----LDPDN---PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007650 205 MFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQ 265
Cdd:COG4783   82 LLKAGDYDE---ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 169-263 1.61e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.95  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 169 WTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRMGEE 248
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE---AKEYYEKALALSPDNPNAYSNLAALLLSLGQD 138

                         90
                 ....*....|....*
gi 569007650 249 AEGERLIKDALGKAP 263
Cdd:COG5010  139 DEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 94-229 6.51e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 6.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  94 AALECLGQAEDLRKSEHKDQAEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSmecpelecEEGWTRLK 173
Cdd:COG5010   29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYY--------NLALLYSR 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650 174 CGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNP 229
Cdd:COG5010  101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE---AKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
175-264 1.23e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 175 GRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfsVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERL 254
Cdd:COG3063    6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDE----AIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                         90
                 ....*....|
gi 569007650 255 IKDALGKAPN 264
Cdd:COG3063   82 LERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 217-295 1.89e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 1.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007650 217 SVDALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRS 295
Cdd:COG5010   73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 79-223 4.59e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.67  E-value: 4.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  79 YDLLAYIKHLDGESKAALECLGQAEDLrkseHKDQAEIrrlvtWGNYAWIYYHMGRLSEAQAYVDKVRQVcqkfaNPysm 158
Cdd:COG3914  115 LFNLGNLLLALGRLEEALAALRRALAL----NPDFAEA-----YLNLGEALRRLGRLEEAIAALRRALEL-----DP--- 177

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007650 159 ECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQ 223
Cdd:COG3914  178 DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAA 242
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 81-325 1.15e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650   81 LLAYIKHLDGESKAALECLGQAEDLRKsehKDQAEIRRLVTwgnyawIYYHMGRLSEAQAYVDKVRQvcqKFANPysmec 160
Cdd:TIGR02917 198 LKGDLLLSLGNIELALAAYRKAIALRP---NNIAVLLALAT------ILIEAGEFEEAEKHADALLK---KAPNS----- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  161 PELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLE--EKPEKQFSvDALKQAmelnPQNQYVKVLL 238
Cdd:TIGR02917 261 PLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLN-QILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  239 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS------LVMCRYRE 312
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTqlgiskLSQGDPSE 415

                         250
                  ....*....|...
gi 569007650  313 ILEQLQNKGDADS 325
Cdd:TIGR02917 416 AIADLETAAQLDP 428
TPR_12 pfam13424
Tetratricopeptide repeat;
76-151 1.20e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650   76 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHKDQAEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 151
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
166-294 1.65e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.90  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 166 EEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYVKVLLALKLLRM 245
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA---ALEDFDRALELDPDYAYAYLNRGIALYYL 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007650 246 GEEAEGERLIKDALGKAPN-----------QTDVLQKAAQF---------YKKKGNLDRAIELLGKALR 294
Cdd:COG4785  155 GRYELAIADLEKALELDPNdperalwlylaERKLDPEKALAllledwataYLLQGDTEEARELFKLALA 223
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
219-294 2.15e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007650 219 DALKQAMELNPQNQYVKVLLALKLLRMGEEAEGERLIKdALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 294
Cdd:COG3063   13 EYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEK-ALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
TPR_12 pfam13424
Tetratricopeptide repeat;
118-189 2.59e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 2.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007650  118 RLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALE 189
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR_19 pfam14559
Tetratricopeptide repeat;
246-306 3.26e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.02  E-value: 3.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007650  246 GEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLV 306
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
76-262 4.45e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  76 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHKdqaeirrlvTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANP 155
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAE---------ALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650 156 YsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYVK 235
Cdd:COG0457  147 L--------YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218

                        170       180
                 ....*....|....*....|....*..
gi 569007650 236 VLLALKLLRMGEEAEGERLIKDALGKA 262
Cdd:COG0457  219 LAELLLLALALLLALRLAALALYQYRA 245
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 168-301 5.17e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  168 GWTRLKCGRNERAKMCFEKALEEKPKDPecSSGMAIAMFRLEE-KPEKQFSvdALKQAMELNPQNQYVKVLLALKLLRMG 246
Cdd:TIGR02917 370 GEAYLALGDFEKAAEYLAKATELDPENA--AARTQLGISKLSQgDPSEAIA--DLETAAQLDPELGRADLLLILSYLRSG 445

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569007650  247 EEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSP 301
Cdd:TIGR02917 446 QFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFP 500
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 89-306 8.24e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650   89 DGESKAALECLGQAedLRKSEhkDQAEIRRLVtwgnyAWIYYHMGRLSEAQAYVDKVRQVcqkfanPYSME--CPELece 166
Cdd:TIGR02917  35 KNKYKAAIIQLKNA--LQKDP--NDAEARFLL-----GKIYLALGDYAAAEKELRKALSL------GYPKNqvLPLL--- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007650  167 egwTRLKCGRNErakmcFEKALEEKPKDPECSSGMA--------IAMFRLEEKPEKQfsvDALKQAMELNPQNQYVKVLL 238
Cdd:TIGR02917  97 ---ARAYLLQGK-----FQQVLDELPGKTLLDDEGAaellalrgLAYLGLGQLELAQ---KSYEQALAIDPRSLYAKLGL 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007650  239 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNN-SPLYSLV 306
Cdd:TIGR02917 166 AQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNiAVLLALA 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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