|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
22-416 |
0e+00 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 584.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:cd17424 20 RCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRp 181
Cdd:cd17424 100 VLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMR- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 itlkedrsvpeknhnresqredckqaspyspltkectetrlccslqqeygFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP 261
Cdd:cd17424 179 --------------------------------------------------FLLMPDFLVLAVSVLFLAYGCSPPFVYLVP 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 262 YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:cd17424 209 YALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYF 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17424 289 DGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
22-416 |
5.27e-111 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 332.21 E-value: 5.27e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:cd17352 20 NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRp 181
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 itlkedrsvpeknhnresqredckqaspyspltkectetrlccslqqeygFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP 261
Cdd:cd17352 179 --------------------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 262 YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKnyRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:cd17352 209 YAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIG--RLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFC 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
22-413 |
4.95e-91 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 284.33 E-value: 4.95e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:TIGR00892 36 KAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRP 181
Cdd:TIGR00892 116 FITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 ITLKEDRSVPEKnhnresqredcKQASPYSPLTKECTETRLCCSLQQEYGFLLMSD--FVVLAVSVLFMAYGCSPLFVYL 259
Cdd:TIGR00892 196 VGPSQRVSKSKS-----------KEGLPPDGSTKKLSKKSTAEKINRFLDFSLFTHrgFLVYLSGNVIMFLGFFAPIIFL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 260 VPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFG 339
Cdd:TIGR00892 265 VPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFG 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007255 340 YFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLG 413
Cdd:TIGR00892 345 LSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLA 418
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
20-413 |
1.33e-88 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 275.42 E-value: 1.33e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 20 LCRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLS 99
Cdd:cd17423 18 VLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLC 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 100 LGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALM 179
Cdd:cd17423 98 IGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPCGALL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 180 RPITLKEDRSVPEKnhnresqredckqaSPYSPltkectetrlccslqQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYL 259
Cdd:cd17423 178 RPLALPGDPPAPPR--------------SLSAA---------------FGLSLLTHRAFLRYALATTLINTGYFIPYVHL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 260 VPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKnyryVCYLFAV--ALDGLCYLCLPMLQTFPLLVPFSCT 337
Cdd:cd17423 229 VAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLR----LLHLLVLwtALTGLSLLLLPLAKVYGSLLALAVA 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569007255 338 FGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCG-FAMIFSSILLG 413
Cdd:cd17423 305 YGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGsFLLLGSLILLT 381
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
22-414 |
2.02e-72 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 233.08 E-value: 2.02e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:cd17430 20 KAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRP 181
Cdd:cd17430 100 VITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVMRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 ITLK--EDRSvpeknhnresqredckqaspyspltkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYL 259
Cdd:cd17430 180 LDFSvfRDRG------------------------------------------------FVIYTIAKFIMVLGLFVPPIFV 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 260 VPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDrrcLKNYR-YVCYLFAVAL--DGLCYLCLPMLQTFPLLVPFSC 336
Cdd:cd17430 212 VNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAG---LKWVRpRVVYLFSFAMlfNGLTDLCSATAADYGGLVVFCV 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007255 337 TFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGF 414
Cdd:cd17430 289 FFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
26-416 |
6.73e-69 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 223.86 E-value: 6.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 26 IFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTG 105
Cdd:cd17422 24 VFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYLTIGIISG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 106 LGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPItlk 185
Cdd:cd17422 104 LGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGALLRVL--- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 186 edrsvpeknhnresqredckqaspyspltkectetrlccslqQEYGFLLMSDFvvlavsVLFMAYGCSPLFVYLVPYALS 265
Cdd:cd17422 181 ------------------------------------------KEPGFICYALF------GLFATLGFFAPQLYIIPLSLS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 266 VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYrYVCYLFAVALdGLCYLCLPMLQTFPLLVPFSCTFGYFDGAY 345
Cdd:cd17422 213 LGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKI-YIELICVILL-CVVLLLFPFAYGFWSLLVCSIFYGFMFGTV 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007255 346 V-TLIPVVTAE-IVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17422 291 AgTHIPLLAEDdVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
23-414 |
2.55e-64 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 211.94 E-value: 2.55e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 23 CISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGV 102
Cdd:cd17425 21 CIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 103 LTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPI 182
Cdd:cd17425 101 ITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVMRPF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 tlkedrsvpeknhnresqredckqaspyspltkeCTETRLCcslqqeygfllmsdfvVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:cd17425 181 ----------------------------------CSNTRYQ----------------IYTLGVTWMVLGFVLPLIYLVPY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFD 342
Cdd:cd17425 211 ATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISM 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007255 343 GAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGF 414
Cdd:cd17425 291 SGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
22-412 |
5.84e-64 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 211.21 E-value: 5.84e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:cd17427 20 KAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLGMISASFCNSVMQLYLCIG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRP 181
Cdd:cd17427 100 VIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFLILGGLLLNCCVAGSLMRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 ItlkedrsvpeknhnresqredckqaspySPLTKectetrlccslqqEYGFLlmsdfVVLAVSVLfMAYGCSPLFVYLVP 261
Cdd:cd17427 180 L----------------------------GPLFK-------------HRGFL-----IYLSGNVI-MFLGFFAPIVFLAP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 262 YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:cd17427 213 YAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFA 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17427 293 FGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
26-420 |
2.75e-59 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 198.89 E-value: 2.75e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 26 IFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTG 105
Cdd:cd17421 24 IFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVPFLYVSMGLLVG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 106 LGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIgTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPItlk 185
Cdd:cd17421 104 LGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGALLIFGGIMLNLVASGMLLRPI--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 186 edrsvpeknhnresqredckqaspyspltkectetrlccslqqEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALS 265
Cdd:cd17421 180 -------------------------------------------DFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARART 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 266 VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRY-VCYLFavaLDGLCYLCLPMLQTFPLLVPFSCTFGYFDGA 344
Cdd:cd17421 217 LGIDPMDASFIISVAGITETVAQLASGWIADQNWIKKYHYhKAYLI---LCGVTNLLAPLATTYPLLMTYAVFFAIFCGG 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007255 345 YVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKR 420
Cdd:cd17421 294 YLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEPLARR 369
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
22-412 |
2.17e-56 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 191.63 E-value: 2.17e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 22 RCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLG 101
Cdd:cd17426 20 KSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 102 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRP 181
Cdd:cd17426 100 VVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 182 ITLKedrsvpeknhnresqredckqasPYSPLTkectetrlccsLQQEYGFLLMSDFVVLAVSVLFmaygcSPLfVYLVP 261
Cdd:cd17426 180 IGPK-----------------------PFLDLT-----------LFTHRGFLLYLSGNVIMFFGLF-----APL-VFLSN 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 262 YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:cd17426 220 YAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFA 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17426 300 FGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
24-412 |
1.11e-49 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 173.48 E-value: 1.11e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVL 103
Cdd:cd17429 22 LGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPIT 183
Cdd:cd17429 102 AGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMRLFT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 184 LKEdrsvpeknhnresqredckqaspyspltkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYLVPYA 263
Cdd:cd17429 182 NKV---------------------------------------------------FVAFIFWALFAYCSFVIPFIHLPEIV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 264 LSVGVSHHQAAF-LMSILGVIDIVGNITFGWLTDRRCLKNYRyvCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFD 342
Cdd:cd17429 211 KLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWN--VFILANFTLGVCILILPLMHTYTGLAIVCALIGFSS 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 343 GaYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17429 289 G-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICL 357
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
73-415 |
8.48e-42 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 152.81 E-value: 8.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMV-GKYFSRRKALAYGIAMSGSGIGTFILAPVVQL 151
Cdd:cd17355 71 MLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 152 LIEQFSWRGALLILGGfvlnlcVCGALMRPITLKEDRSVPEKNHNRESqreDCKQASPYSPLTKECTetrlccslqqeyg 231
Cdd:cd17355 151 LIEAFGWRTALLVLAL------LALLVLVPVLLLLRRRPADLALRAYD---DASPASPGSTLKEALR------------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 232 fllMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclKNYRYVCYLFA 311
Cdd:cd17355 209 ---SASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR---YSPRRLLAASY 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 312 vALDGLCYLCLPMLQ-TFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDT 390
Cdd:cd17355 283 -ALRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
|
330 340
....*....|....*....|....*
gi 569007255 391 TGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17355 362 TGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
40-415 |
8.21e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 142.28 E-value: 8.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 40 SQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMV 119
Cdd:cd17420 43 FKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVIL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 120 GKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNRES 199
Cdd:cd17420 123 GHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLH 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 200 QRedcKQASPYSPLTKECTETRlccslqqeygfllmsDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSI 279
Cdd:cd17420 203 SR---INLFLRKIFNVEIFKRK---------------RYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMC 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 280 LGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALdGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGT 359
Cdd:cd17420 265 IGITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSI-GLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGP 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 569007255 360 TSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17420 344 SGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-415 |
3.39e-37 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 140.44 E-value: 3.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 25 SIFFVEFQTYFAQDYSQTAWIHSI-VDCMTMLCAPLGSVVSNqLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVL 103
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLtIVFLAISAPFAGRLVDR-GGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILG-GFVLNLCVCGALMRPI 182
Cdd:cd17353 102 GGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGiIFLIIIVIGAFLIRDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 tlKEDRSVPEKNHNRESQREDCKQASPyspltKECTETRlccslqqeygfllmsDFVVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:cd17353 182 --PKGWVPPGVDPLANNAENSPRDYTP-----REMLRTP---------------TFWLLWLMFFLNATAGLMLIGQAKPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKnyRYVCYLFAVALDGLCYLCLPMLQ-TFPLLVPFSCTFGY 340
Cdd:cd17353 240 GQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDK--IG--RKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 341 FDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWlVDTTGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17353 316 CYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-420 |
6.20e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 136.93 E-value: 6.20e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLyLSLGVL 103
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL-LLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMrpI 182
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLF--L 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 TLKEDRSVPEKNHNRESQREDCKQaspyspltkectetrlccslqqeYGFLLMSDFVVLAVSVLFMaygcspLFVYLVPY 262
Cdd:COG2223 181 RDPPAGAAAAAKASLRDQLEALRD-----------------------PRFWLLSLLYFGTFGSFIG------FSSWLPPY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclknYRYVCYLFAVALDGLCYLCLPMLQ-TFPLLVPFSCTFGY 340
Cdd:COG2223 232 LVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 341 FDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKR 420
Cdd:COG2223 308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
24-412 |
9.91e-35 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 133.02 E-value: 9.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVL 103
Cdd:cd17428 22 VGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIFSYGIV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRpit 183
Cdd:cd17428 102 VGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVGALALNLLACGSLMR--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 184 LKEDRSvpeknhnresqredckqaspyspltkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYLVPYA 263
Cdd:cd17428 179 LFKNRV------------------------------------------------FSALFIAILLFDIGAFPPSLLMEDVA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 264 LSVGVSHHQAAF-LMSILGVIDIVGNITFGWLTDRRCLkNYRYVcYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFD 342
Cdd:cd17428 211 RSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV-NSLYL-YVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLS 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 343 GAYvTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17428 289 GNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-416 |
1.51e-34 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 132.69 E-value: 1.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLgVL 103
Cdd:COG2271 29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR-FL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLnlcVCGALMrpi 182
Cdd:COG2271 108 LGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL---LLALLR--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 tlkedrsvpeknhnresqredckqaspyspltkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:COG2271 182 -------------------------------------------------------FWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:COG2271 207 LVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
24-415 |
6.46e-32 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 125.60 E-value: 6.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVL 103
Cdd:cd17314 22 WSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPit 183
Cdd:cd17314 102 IGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGF-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 184 lkedrsvpeknhnRESQREDckqaspyspltkecTETRLCCSLQQEYGFLL-MSDFVVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:cd17314 180 -------------KEPPDNQ--------------ARLHVQKKKTQTMGEIFrDKVFWILFIAIFLVLIGGFLFIANMASL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSVGVSHHQ-AAFLMSILGVIDIVGNITFGWLTDRRcLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:cd17314 233 VRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFS 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17314 312 YGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
41-415 |
6.36e-29 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 117.59 E-value: 6.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 41 QTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVG 120
Cdd:cd17464 44 KTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 121 KYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNHNResq 200
Cdd:cd17464 124 HYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFK--- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 201 redckqaspyspltkectetrlCCSLQQEYGFLL--MSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMS 278
Cdd:cd17464 201 ----------------------CPPLKKIFNFNIwkSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLM 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 279 ILGVIDIVGNITFGWLTDR--RCLKNYRYVCYLFAValdGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEI 356
Cdd:cd17464 259 CIGITSGIGRLIFGRVADYipGVKKVYLQVSSFFFI---GLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFEL 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 569007255 357 VGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17464 336 VGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFI 394
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-413 |
8.15e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.50 E-value: 8.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 38 DYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSlGVLTGLGFALCYSPAIA 117
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG-TALIGAGIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 118 MVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGfvlnLCVCGALMRPITLKEDRSVPEKNHNR 197
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL----LALLALLLWLPLLRRRPAAAAAAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 198 ESQREDCKqaspySPLtkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLM 277
Cdd:COG2807 206 ASLRSLWR-----SPL------------------------AWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 278 SILGVIDIVGNITFGWLTDRrcLKNYRYVCYLFAVALdGLCYLCLpMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIV 357
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADR--LGDRRPLLLLLGLLG-LAGLLGL-LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 358 GTTSLSSAL-GVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLC---GFAMIFSSILLG 413
Cdd:COG2807 333 RTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLaalAVLMLVAGLLAG 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-375 |
6.28e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.36 E-value: 6.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLsLGVL 103
Cdd:COG2814 29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGfvlnLCVCGALMRPI 182
Cdd:COG2814 108 QGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV----LALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 TLKEDRsVPEKNHNRESQREdckqaspyspltkectetrlccslqqeygFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:COG2814 184 LLPESR-PAARARLRGSLRE-----------------------------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclknYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYF 341
Cdd:COG2814 234 LQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRF----GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFG 309
|
330 340 350
....*....|....*....|....*....|....
gi 569007255 342 DGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAV 375
Cdd:COG2814 310 FGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-412 |
2.99e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.96 E-value: 2.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLgVL 103
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR-FL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQ--FSWRGALLILGGFVLNLCVCGALMr 180
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 181 pitlkedrsVPEKNHNRESQREDCKQASPYSPLTKectetrlccslqqeygFLLMSDFVVLAVSVLFMAYGCSPLFVYLV 260
Cdd:cd06174 173 ---------VPDPPESARAKNEEASSKSVLKLLKR----------------VLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 261 PYALS-VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRClknYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFG 339
Cdd:cd06174 228 LFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI---GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007255 340 YFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-381 |
3.60e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.41 E-value: 3.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLsLGVL 103
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV-LRVL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 104 TGLGFALCYSPAIAMVGKYFSR-RKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPi 182
Cdd:pfam07690 95 QGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 183 tlkedrsVPEKNHNRESQREDCKQASPYSpltkectetrlccslqqeygFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPY 262
Cdd:pfam07690 174 -------PPESKRPKPAEEARLSLIVAWK--------------------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 263 ALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALdGLCYLCLPMLQTFPLLVPFSCTFGYFD 342
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSLTLSSLWLLLALLLLGFGF 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 569007255 343 GAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSP 381
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
41-415 |
4.50e-19 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 88.70 E-value: 4.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 41 QTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVG 120
Cdd:cd17465 44 KTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 121 KYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVcgalmrpitlkedrsvpeknhnresq 200
Cdd:cd17465 124 HYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLSLFMFIQIF-------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 201 redckqaspyspltkectetrlccsLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSIL 280
Cdd:cd17465 178 -------------------------LSLTYKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 281 GVIDIVGNITFGWLTDrrCLKNYRYVcYLFAVA--LDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVG 358
Cdd:cd17465 233 GASSGIGRLMSGKIGD--LIPGLKKI-YLQVASflLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVG 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 569007255 359 TTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17465 310 PMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFV 366
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
73-416 |
5.76e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.40 E-value: 5.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLASTGFILGSFATSLKHLYLSLgVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIGTFILAPVVQL 151
Cdd:cd17325 64 LLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 152 LIEQFSWRGALLILGGFVLnlcvCGALMRPITLKEDRSVPEKNHNRESqredckqaspyspltkectetrlccSLQQEYG 231
Cdd:cd17325 143 LADALGYRAPFLVCAALAL----LALVLALLLLPEPRPPPNKRAVSAA-------------------------RLRSGLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 232 FLLM-SDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRClknyRYVCYL 309
Cdd:cd17325 194 LLLRdRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG----RKPLIL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 310 FAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVD 389
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
330 340
....*....|....*....|....*..
gi 569007255 390 TTGsYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17325 350 AFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
85-415 |
5.71e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.93 E-value: 5.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 85 ILGSFATSLKHLYLsLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 163
Cdd:cd17319 83 ALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 164 ILGGFvlnlcvcGALMRPITlkedrsvpeknhnresqredckqaspyspltkectetrlccslqqeygFLLMSDFVVLAV 243
Cdd:cd17319 162 IEGLL-------GLLLAVLW------------------------------------------------WFYLRQVWGLAL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 244 SVLFMAYGCSPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFaVALDGLCYLCL 322
Cdd:cd17319 187 GYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIG-LLLAAVGLLLA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 323 PMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCG 402
Cdd:cd17319 266 YLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLA 345
|
330
....*....|...
gi 569007255 403 FAMIFSSILLGFV 415
Cdd:cd17319 346 AVALLAALLVLLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
75-412 |
2.68e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.44 E-value: 2.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 75 LGGLLASTGFILGSFATSLKHLYLSLgVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLI 153
Cdd:cd17475 66 VGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGSVQPGGGRAIMRWFPpRERGLAMGIRQTGVPLGGALAAALLPPLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 154 EQFSWRGALLILGGfvlnLCVCGALMRPITLKEdrsvpEKNHNRESQREDCKQASPYSPLTKectetrlccslqqeygfl 233
Cdd:cd17475 145 LHYGWRAAFVVAGL----VSILAAVLFWLFYRE-----PPAASAATESASTLLRSLKEVLRN------------------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 234 lmSDFVVLAVSVLFMAYGCSPLFVYLVPYALS-VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYR--YVCYLF 310
Cdd:cd17475 198 --RDVWLIAIAGALLVAPQFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRpvLVITAA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 311 AVALDGLCYLCLPMLQTFPLLVPFSCTFGYF----DGAYVTLIpvvtAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGW 386
Cdd:cd17475 276 IAAAALLVLSLLSPGTPLWLLVLLLILLGLFaigwNGLYLTLV----AESAGPEQAGTALGLANTINFIGIAIGPPLFGL 351
|
330 340
....*....|....*....|....*.
gi 569007255 387 LVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17475 352 LVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-416 |
1.94e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 44 WIHSIVDCMTMLCAPLGSVVSNQLScQAGIMLGGLLASTGF-ILGSFATSLKHLYLSLGVLtGLGFALCYSPAIAMVGKY 122
Cdd:cd17473 39 LLLTLPALFIALFAPLAGWLADRFG-RKRLLIAGLLLYGIGgVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 123 FS---RRKALAY-GIAMSGSGIgtfILAPVVQLLIEqFSWRGALLI-LGGFVLNLCVCgalmrpitlkedRSVPEKNHNR 197
Cdd:cd17473 117 FEgeeRAKMLGLqSAAMSLGGV---VFLLLGGALAE-IGWRAPFLVyLLALPVLILVL------------LFLPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 198 ESQREDCKQASPYSPLTKectetrlccslqqeygfLLMSDFVVLAVSVLFMAygcspLFVYLVPYALSVG-VSHHQAAFL 276
Cdd:cd17473 181 KSAASPGAATAAALPWKR-----------------VLPIYFLAFLAMLLFYV-----IPIQLPFLLQERGgGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 277 MSILGVIDIVGNITFGWLTDRRClknyRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEI 356
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLG----KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007255 357 VGTTSLSSALGVV---YFLHAvpyLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17473 315 VPPELRGRAMGIVtsaFFLGQ---FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
239-416 |
6.46e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.75 E-value: 6.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 239 VVLAVSVLFMAYGCspLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRClknyRYVCYLFAVALDGLC 318
Cdd:cd17325 1 LSLALFLDMLGYGI--IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG----RKRLLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 319 YLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAF 398
Cdd:cd17325 75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF 153
|
170
....*....|....*...
gi 569007255 399 LLCGFAMIFSSILLGFVR 416
Cdd:cd17325 154 LVCAALALLALVLALLLL 171
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
241-423 |
6.61e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.59 E-value: 6.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 241 LAVSVLFMAYGCSPLFVYLVPY-ALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRClknyRYVCYLFAVALDGLCY 319
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----RRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 320 LCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFL 399
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170 180
....*....|....*....|....
gi 569007255 400 LCGFAMIFSSILLGFVRIVKRMKR 423
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKR 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
238-415 |
8.00e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 8.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 238 FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVcYLFAVALDGL 317
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRV-LLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 318 CYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAA 397
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166
|
170
....*....|....*...
gi 569007255 398 FLLCGFAMIFSSILLGFV 415
Cdd:COG2814 167 FLVNAVLALLALLLLLRL 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-412 |
1.52e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.57 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLgVLTGLGFAL 110
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 111 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSV 190
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 191 PEKNHNRESQREDckqaspyspltkectetrlccslqqeYGFLLMSDFVVLAVSVLFMAygcspLFVYLVPYALSVGVSH 270
Cdd:cd17478 181 AAKSSARSTLKGV--------------------------WRALLLLLIIVFLRSWVLSS-----LTTFLPFYLVQRGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 271 HQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVcYLFAVALDGLCYLCLPMLQTFPLLVPFSCtFGYFDGAYVTLIP 350
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDRF---GRRRV-IIASLLLAAPFLLLFLLTPGIWSYILLVL-AGFLLFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 351 VVTAEIV-GTTSLSSAL--GVVYFLHAvpylVSPPIAGWLVDTTGsYTAAFLLCGFAMIFSSILL 412
Cdd:cd17478 305 VLAQELLpGNVGLASGLmmGLSFGLGG----IGAPVLGALADAFG-LESVLLILALLPLLGALLA 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-425 |
6.06e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.02 E-value: 6.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLtGLGFAL 110
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL-GLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 111 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ---FSWRGALLILGGFVLnlcVCGALMRPITLKED 187
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLL---LLALLFLRSKLPEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 188 RSVPEKNHNRESQREdckqaspyspltkectetrlccSLQQEYGFLLMSDFVVLAVSVLFMAYGCSPLFVylvpyALSVG 267
Cdd:COG0738 190 EEEEEEAAGSAASLK----------------------SLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL-----KDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 268 VSHHQAAFLMSILGVIDIVGNITFGWLTDRrcLKNYRYVCYLFAVALdgLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVT 347
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKR--FGPVRLLRLSALLAA--VGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007255 348 LIPVVTAEIVGTTSlSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFLLCGFAMIfssILLGFVRIVKRMKRTQ 425
Cdd:COG0738 319 TIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYL---LILLLALALKRKRRKK 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-407 |
6.58e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 6.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILgSFATSLKHLYLSLGVLTGLGFAL 110
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL-IFATPSIYLFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 111 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ-FSWRGALLILGGFVLNLCVCGALMRpitlkedrs 189
Cdd:cd17333 101 LDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLTL--------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 190 VPEKNHNRESQREDCKQASPYSPLTKECtetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYLVP-YALSVGV 268
Cdd:cd17333 172 FPELPSARNPQQSVGAFSASASRLLRNP--------------------SIILGALALFLYVGAETAFSSWVPsYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 269 SHHQ-AAFLMSILGVIDIVGNITFGWLTDRrclknYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTF-GYFDGAYV 346
Cdd:cd17333 232 VSDGlAGYLLSGFWVGITIGRLLGGPISRR-----IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALlGLFMAALF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007255 347 TLIPVVTAEIVGTTSlSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIF 407
Cdd:cd17333 307 PTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAII 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
73-421 |
1.41e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.92 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLASTGFIL----GSFATSLKHLYLSLG-VLTGLGFALCYSPAIAMVGKYFS--RRKALAYGIAMSGSGIGTFIL 145
Cdd:COG2211 84 ILIGAIPLALSFVLlftaPDLSPTGKLIYALVTyLLLGLAYTLVNIPYSALGAELTPdyEERTRLSSWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 146 APVVQLLIEQFS------WRGALLILGGfvlnLCVCGALMRPITLKEDRSVPEKnhnRESQREDCKQASPYSPLtkecte 219
Cdd:COG2211 164 SVLPPPLVAAFGgdaalgYRLTALIFAV----LGLLAFLLTFFGTKERPVPEEE---KVSLKESLKALLKNRPF------ 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 220 trlccslqqeyGFLLMSDFVVLAVSVLFMAYgcsplFVYLVPYALsvGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRC 299
Cdd:COG2211 231 -----------LLLLLAYLLFFLALALVAAL-----LLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 300 LKNyryvCYLFAVALDGLCYLCLPMLQ--TFPLLVPFSCTFGYFDGAYVTLIPVVTAEIV-------GTTSLSSALGVVY 370
Cdd:COG2211 293 KKK----AFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFT 368
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 371 FLHAVPYLVSPPIAGWLVD--------------TTGSYTAAFLLCGFAMIFSSILLGFVRIVKRM 421
Cdd:COG2211 369 FAIKLGQALAGALAGLLLAlfgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
230-412 |
2.61e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.77 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 230 YGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVCY 308
Cdd:cd17316 171 LALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 309 LFAVALDGLCY-LCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWL 387
Cdd:cd17316 248 IGLILSGILALpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
170 180
....*....|....*....|....*
gi 569007255 388 VDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17316 328 LASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
35-415 |
3.12e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 3.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 35 FAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLyLSLGVLTGLGFALCYSP 114
Cdd:cd17474 29 LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 115 AIAMVGKYFS---RRKALAYGIAMSGSGIGTFilaPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVP 191
Cdd:cd17474 108 ALTLIGDLFEggeRAKAMGLYEAALGLGIAVG---PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 192 EKNHNRESQREDCKQaspyspltkectetrlccslqqeygfllmsdFVVLAVSVLFMAYGCSPLFVYL-VPYALSVGVSH 270
Cdd:cd17474 185 ATKLRDLKKALRGRG-------------------------------LLTFLVSAFLYFFLYFAFLTYLpFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 271 HQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYryvCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIP 350
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRFGARR---ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 351 VVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFLLCGFAMIFSSILLGFV 415
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
72-388 |
5.70e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.75 E-value: 5.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 72 GIMLGGLLASTGFILGS-FATSLKHLyLSLGVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVV 149
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCaLATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYAPkRFRGTAVGLMFCGYPIGAAVGGFLA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 150 QLLIEQFSWRGALLIlgGFVLNLCVCGALMRpiTLKED-----RSVPEKNHNRESQREDCKQASPYSPLTKECTETRLCC 224
Cdd:TIGR00895 162 GWLIPVFGWRSLFYV--GGIAPLLLLLLLMR--FLPESidflvSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKR 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 225 SLQQeygfLLMSDFVVLAVSVLFMAYGCSPLFVYLV----PYALS-VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRC 299
Cdd:TIGR00895 238 SVFK----ALFQGKTARITVLLWLLYFMLLVGVYFLtnwlPKLMVeLGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 300 LKNYRYVCYLFAValdgLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLV 379
Cdd:TIGR00895 314 PRVTALLLLLGAV----FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAII 389
|
....*....
gi 569007255 380 SPPIAGWLV 388
Cdd:TIGR00895 390 GPILAGYLL 398
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
239-412 |
5.42e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 5.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 239 VVLAVSVLFMAYGCSPLFVYlvpYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclkNYRYVCYLFAVALDGLC 318
Cdd:cd17370 205 YLLAVALFALGNFSFAFLIL---RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR----IGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 319 YLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTgSYTAAF 398
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SPSAAF 356
|
170
....*....|....
gi 569007255 399 LLCGFAMIFSSILL 412
Cdd:cd17370 357 LFSAVLALIALLLL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-411 |
6.66e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.48 E-value: 6.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 40 SQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLsLGVLTGLGFALCYSPAIAMV 119
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAHGGFWAIAAAYA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 120 GKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGgfVLNLCVCGALMRPItlkedRSVPEKNhnre 198
Cdd:cd17324 113 ADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA--VLALLAALLLWRLL-----PSLPPKK---- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 199 sqredckqASPYSPLTkectetrlccslqqEYGFLLMSDFVVLAVSVLFMAYGC-SPLFVYLVPYALSV-GVSHHQAAFL 276
Cdd:cd17324 182 --------PGSLGLLS--------------SLLLLLRNPRLRLAYLITFLLFGGfFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 277 MSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEI 356
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 569007255 357 VGTTslSSALGVVYFLHAVpylVSPPIAGWLVDTTGsYTAAFLLCGFAMIFSSIL 411
Cdd:cd17324 320 RGLA--SSLYLAAYNLGGA---LGAALGGLVLDHGG-WAGVGWVGAALLLLALLL 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
241-411 |
1.32e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 241 LAVSVLFMAYGCSPLFVYLVPYAL-----SVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVcYLFAVALD 315
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAApplqaDLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF---GRRRV-LAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 316 GLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYT 395
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WR 164
|
170
....*....|....*.
gi 569007255 396 AAFLLCGFAMIFSSIL 411
Cdd:COG2271 165 AAFLILGLPGLLLALL 180
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
239-415 |
4.21e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 4.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 239 VVLAVSVLFMAYGCspLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVCYLFAVALdGLC 318
Cdd:cd06174 1 LLLGFFLTGLARGL--ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF---GRRPVLLLGLLLF-ALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 319 YLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVD-TTGSYTAA 397
Cdd:cd06174 75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAV 154
|
170
....*....|....*...
gi 569007255 398 FLLCGFAMIFSSILLGFV 415
Cdd:cd06174 155 FLIAAALALLAAILLLLV 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
240-415 |
5.16e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 5.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 240 VLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclKNYRYVCYLFAVALDGLCY 319
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR---FDRRRVLLGCALLGALAAL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 320 LCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYtaafl 399
Cdd:cd17477 269 LLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH----- 343
|
170
....*....|....*.
gi 569007255 400 lcGFAMIFSSILLGFV 415
Cdd:cd17477 344 --GLFLFLAAVALLFL 357
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
78-412 |
5.61e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 78 LLASTGFILGSFATSLKHLYLSLGV---LTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLI 153
Cdd:cd17365 68 LVSVALFGLFTLLTAFAQSVLQLALlrfLTGLGLGAAMPNAITLVSEYAPaRRRSLAVTLMFCGYPLGAALGGFLAAALI 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 154 EQFSWRGALLILGGFVLnlcVCGALMRpITLKedrsvpeknhnresqredckqaspyspltkectetrlccslqqeygfl 233
Cdd:cd17365 148 PAFGWRSVFLLGGVPPL---ILLPLLR-GTLL------------------------------------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 234 lmsdFVVLAVSVLFMAYGcspLFVYLvPYAL-SVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAV 312
Cdd:cd17365 176 ----LWVTFFMGLLLVYL---LNSWL-PKLMvEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 313 AldglcylCLPMLQTFPLLVPFSCTFGYFDGAYV----TLIPVVTAEIVGT----TSLSSALGVVyFLHAVpylVSPPIA 384
Cdd:cd17365 248 V-------SLALLGVSPASLVLLYVLVFLAGACVngaqVGLYALAARFYPTevraTGVGWALGVG-RLGAI---LGPLLG 316
|
330 340
....*....|....*....|....*...
gi 569007255 385 GWLVDTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17365 317 GLLLAAGLGPESVFLALAIPAALGALAV 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
31-181 |
7.60e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 7.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQL-SCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFA 109
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007255 110 LCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRP 181
Cdd:COG2271 287 GAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
55-413 |
2.09e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 55 LCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIamVGKYFSRRKAL---AY 131
Cdd:cd17339 49 VFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTALAGAGIAVGNVLLPSL--IKRDFPRRVGLmtgLY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 132 GIAMS-GSGIGTFILAPVVQLLieQFSWRGALLILGGFVLnlcVCGALMRPITLKEDRSVPEKnhnresqredcKQASPY 210
Cdd:cd17339 127 TTSMNlGAALASGLSVPLAQAL--GGGWRGALAIWALPAL---LALLIWLPQLRRRKRAAAAA-----------APLTKI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 211 SPLTKectetrlccslqqeygfllmsdfvVLAVSV-LFMayGCSPLFVY-----LVPYALSVGVSHHQAAFLMSILGVID 284
Cdd:cd17339 191 SVWRS------------------------PLAWQVtLFM--GLQSLLFYtlmawLPTILIDAGLSAATAGWLLSLFQLVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 285 IVGNITFGWLTDRrcLKNYRYVCYLFAVA-LDGLCYLCLPMLQTFPLLVPF-----SCTFGYfdgaYVTLIPVVTAEIVG 358
Cdd:cd17339 245 IPASLLVPILATR--LKNQRPIVVLLAVLfIIGVLGLLFAPTALALLWAVLlglggGAAFSL----ALTLISLRSSDPAE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 569007255 359 TTSLSS-ALGVVYFLHAVpylvSPPIAGWLVDTTGSYTAA---FLLCGFAMIFSSILLG 413
Cdd:cd17339 319 AAALSGmAQSVGYLLAAL----GPLLFGVLHDLTGSWTAPlvlLLALTVLQLVAGLGAG 373
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
55-392 |
2.11e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.68 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 55 LCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKH---LYLSLGVLTGLGFALCYSpaiaMVGKYFSRRK-ALA 130
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVmaaLWALNGIFQGMGWPPCGR----TVTKWFSRSErGTW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 131 YGIAMSGSGIGTFILAPVVQLLIEQF-SWRGALLILGGFVLNLC-VCGALMRPITLKEDRSVPEKNHNRESQREDCKQAS 208
Cdd:TIGR00881 121 VSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSlICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 209 PYSPLTKECTETrlccsLQQEYGFLLMSDFVVlavsVLFMAYGCSPLF-VYLVPyalSVGVSHHQAAFLMSILGVIDIVG 287
Cdd:TIGR00881 201 ELTKKQIFLQYV-----LLNKVLWYISLGYVF----VYVVRTGILDWSpLYLTQ---EKGFSKEKASWAFTLYELGGLVG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 288 NITFGWLTDrRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSC--TFGYFDGAYVTLIPVVTAEIVGTTSLSSA 365
Cdd:TIGR00881 269 TLLAGWLSD-KLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIClfALGFLVYGPQMLIGVIASELAPKKAAGTA 347
|
330 340
....*....|....*....|....*..
gi 569007255 366 LGVVYFLHAVPYLVSPPIAGWLVDTTG 392
Cdd:TIGR00881 348 AGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
74-412 |
2.69e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 74 MLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIGTFILAPVVQLL 152
Cdd:cd17312 71 MSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKErGTVYGIWSTSHNFGGILAPILAASL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 153 IEQFSWRGALLILGGfvlnLCVCGALMRPITLKEDRSVpeknhnresqredckqaspyspltkectetrlccslqqeygf 232
Cdd:cd17312 151 ASYYGWRAAFLVPGI----VGLVVAIILFFFLRDSPPY------------------------------------------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 233 llmsdFVVLAVSVLFMaYGCSPLFVYLVPYALS--VGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLF 310
Cdd:cd17312 185 -----VWVLSLAYAFV-YIVRYACLDWGPLYLYevKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIY 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 311 AVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGT-TSLSSALGVVYFLHAVPYLVSPPIAGWLVD 389
Cdd:cd17312 259 MLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIID 338
|
330 340
....*....|....*....|...
gi 569007255 390 TTGSYTaAFLLCGFAMIFSSILL 412
Cdd:cd17312 339 HYGWST-VFYFLISAALLSVLLL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
238-412 |
5.79e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 238 FVVLAVSVLFMAYGcsPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVCyLFAVALDG 316
Cdd:cd06173 212 LLLLALALFALLGG--ALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLL-LIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 317 LCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTA 396
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSA 364
|
170
....*....|....*.
gi 569007255 397 AFLLCGFAMIFSSILL 412
Cdd:cd06173 365 VFLLAGALLLLAALLL 380
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-170 |
8.27e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.50 E-value: 8.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 24 ISIFFVEFQTYFAQDYSQTAWIHSIvdcmTMLCAPLGSVVSNQLSCQAG----IMLGGLLASTGFILGSFATSLKHLYLs 99
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSA----YLLGRAIGLLLFGRLGDRYGrkrvLLIGLLLFGLASLLCGLAPSPELLIA- 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007255 100 LGVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVL 170
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
74-416 |
8.60e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 47.68 E-value: 8.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 74 MLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSR-RKALAYGIAMSGSGIGTFILAPVVQ-L 151
Cdd:cd06180 67 IRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPaG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 152 LIEQFSWRGALLILGGFVLNLCVCGALMRPitlkedrsvpekNHNRESQREDCKQASPYSPLtkectetrlccslqqeyg 231
Cdd:cd06180 147 LGGGLSWRAGWLALALLSAVLLLLSFLLLR------------RGPSAPTEASAAESAPGLNR------------------ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 232 fllmsdfvvlAVSVLFMAYGCSPL-----FVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNyryv 306
Cdd:cd06180 197 ----------PLWRLALAYGLFGFgyiitATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRR---- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 307 CYLFAVALDGLCYLcLPMLQTFPLLVPFSCtFGYfdGAYVTLIPVVTAEIVGTTSLSS---ALGVVYFLHAVPYLVSPPI 383
Cdd:cd06180 263 ALAANLLVQAVGVL-LPLLSPGPAGLVLSA-VLF--GGTFMAITALVMALARELAPPAaprALALMTASFGVGQILGPLL 338
|
330 340 350
....*....|....*....|....*....|...
gi 569007255 384 AGWLVDTTGSYTAAfLLCGFAMIFSSILLGFVR 416
Cdd:cd06180 339 AGWLADATGGFAPA-LILAAAALVVAALLALLV 370
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
74-412 |
1.28e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 47.37 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 74 MLGGLLASTGFILGSFATSLKHLYLSLGVLTGL--GFALCYSPAIAMVGKYFSRRKALAyGIAMSGSGIGtfILAP-VVQ 150
Cdd:pfam06779 63 LLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVasAAVMIFGSSLILGHATAARRAFVG-ALLFAGVGIG--IALSgLLV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 151 LLIEQFSWRGALLILGGFVLNLCvcGALMRPITLKEDRSvpeknhnresqredcKQASPYSPLTKECTETRLCCSLQQEY 230
Cdd:pfam06779 140 PLGLQLGLGGSSLWYGAGVLSAV--LTLAVFPLLPRRAP---------------RHASAPAPAAKPLQRSLPLWILTLAY 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 231 GFllmsdfvvlavsvlfMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNyryvCYLF 310
Cdd:pfam06779 203 GL---------------AGFGYIITATFLPAMARDGFGGPAAAALFWSLFGLAAALGVLVWLRAAKRWGTRP----ALTA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 311 AVALDGLCYLcLPMLQTFPLLVPFSCTFgyFDGAYVTLIPVVTAEI--VGTTSLSSALGVVYFLHAVPYLVSPPIAGWLV 388
Cdd:pfam06779 264 ALLIQALGVL-LSLLSPSPAGLAVSSLL--FGGTFMAITSLVMQLAreLAPPAPRRLLGLMTASFGIGQILGPLLASLLT 340
|
330 340
....*....|....*....|....
gi 569007255 389 DTTGSYTAAFLLCGFAMIFSSILL 412
Cdd:pfam06779 341 AATGGLTPALLLAAAALVLAALIV 364
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
73-414 |
1.53e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 47.24 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLASTGFILGSFATSLKHLYLSLG-----VLTGLGFAL-------CYSPAIAMVGKYFS---RRKALAYGIAMSG 137
Cdd:cd17313 72 ILVGAPLAALGLILIPNAADIGLALGDGPrtwalVLFVLGIVLldfamnvCQGPVRALLPDLVPpeqRSKANGIINFMGG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 138 SG--IGTFILApVVQLLIEQFSWRGALL----ILGGFVLNLCVCgalmrpITLKedrSVPEKNHNRESQREDCKQASPYS 211
Cdd:cd17313 152 LGgvLGYLLGA-ILWDHNWFGFALGGNLkvpfYIGAIILLVCVL------VTLF---FVKEPPLSPEAGEHSENPSLGEV 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 212 PLTKecteTRLCCSLQQEYGFLLMSDFVVlavsvlFMAYGCSPLF--------VY----LVPYALSVGVShhQAAFLMSI 279
Cdd:cd17313 222 LKSL----LKLLKIMPRSLLRLLLVIFFW------WIAFFPFELFftdymgeeVYhgtsAASSHYGAGVR--MGAWGLLI 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 280 LGVIDIVGNITFGWLTDRRCLKnyryVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGA-YVTLIPVVTAEIVG 358
Cdd:cd17313 290 FSLAFLIFSLPIGKLGKKIGRK----KVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATiNINPYPLVSDYHSE 365
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 569007255 359 TT-SLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFLLCGFAMIFSSILLGF 414
Cdd:cd17313 366 SGrGQGTDTGLLNLAISLAQILVSLLAGPIIDVKG-YGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
78-414 |
2.51e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.53 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 78 LLASTGFILGSFATSLKHLyLSLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIG----TFILAPVVQLL 152
Cdd:cd17371 72 LLFAVFTLLCGFAQNYWQL-LILRALAGLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGwllaTLLAALLFPLL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 153 IEQFSWRGaLLILGGFVLNLCVcgaLMRPiTLKEDRSVPEKnhnRESQREDCKQASPYSPLTKECTETRLCCSLqqeygf 232
Cdd:cd17371 151 PPEIAWRV-LFLLGALPALLVL---FIRR-FVKEPPQWQAA---RAARRHFADRPSLRELFSPPLLRTTLLASL------ 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 233 llmsdfvvLAVSVLFMAYGCSPLFVYLVPYALsvGVSHHQAAFLMSILGVIDIVGNITFGWLTD---RRclKNYRYVCYL 309
Cdd:cd17371 217 --------LATGALGGYYGITTWLPSYLTGER--GLSFEGSAGYLVVTILGGFLGYLAGGFLADrigRR--NNFALFALG 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 310 FAVALdgLCYLCLPMLQTFPLLVPFSCTFGYFD--GAYVTLIPvvtaEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWL 387
Cdd:cd17371 285 SAISI--LLYFFLPLSPTLILILGFPLGFFASGpfSGMGAYLT----ELFPTAVRATAQGFCYNVGRIIGALFPFLVGFL 358
|
330 340
....*....|....*....|....*..
gi 569007255 388 VDTTGSYTAAFLLCGFAMIFSSILLGF 414
Cdd:cd17371 359 ATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
58-401 |
1.05e-04 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 44.56 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 58 PLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKhLYLSLGVLtGLGFALCYSPAIAMVGKYFSRRKAL---AYGIA 134
Cdd:cd17409 52 PLAAKLARRYGLERSLFAALLLIAAGIALRSTGSVWA-LYLGTAII-GAGIAIGNVLLPSLLKRDFPARVATltgAYALT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 135 MS-GSGIGTFILAPVVQllIEQFSWRGALLILggFVLNLcVCGALMRPITlkedrsvpeKNHNRESQREDCKQASPY--- 210
Cdd:cd17409 130 MGvGAALGSALVVPLAQ--VLAFGWQLALGAF--LVFPL-VAALIWLPQL---------RRHTSPAADTAKPPHGGSvwr 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 211 SPLTKECTetrlccslqqeyGFLLMSDFVVLAVsvlfmaygcsplfVYLVPYAL-SVGVSHHQAAFLMSILGVIDIVGNI 289
Cdd:cd17409 196 SPLAWQVT------------LFLGLNSFIYYVL-------------VGWLPSILtDAGYSAAQAGSLHGLLQLATAVPGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 290 TFG----WLTDRRCLKNYryVCYLFAVALDGLCYLclPMLQTFpllvpFSCTFGYFDGAYVTL----IPVVTAEIVGTTS 361
Cdd:cd17409 251 LLIpvlaRMKDQRLLAVL--VSLLGAVGLIGLLLA--PSLAIL-----WVILFGFGSGAGFILglafIGLRTSSAHQAAA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 569007255 362 LSS-ALGVVYFLHAVpylvSPPIAGWLVDTTGSYTAAFLLC 401
Cdd:cd17409 322 LSGmAQCVGYLLAAT----GPMLVGALHDLTGSWSVPLLLC 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
246-433 |
1.33e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 246 LFMAYGCSPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALdgLCYLCLPM 324
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAI--PLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 325 LQTFPLLVP-------------FSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHA--VPYLVSPPIAGWLVD 389
Cdd:COG2211 98 LFTAPDLSPtgkliyalvtyllLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGllASVLPPPLVAAFGGD 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 569007255 390 TTGSYTAAFLLCGFAMIFsSILLGFVRIVKRMKRTQVPFPVKDS 433
Cdd:COG2211 178 AALGYRLTALIFAVLGLL-AFLLTFFGTKERPVPEEEKVSLKES 220
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
73-412 |
1.65e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.72 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLAstgFILGS----FATSLkHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIgTFILAP 147
Cdd:cd17320 66 VLLAGLLL---FILASllcaLASSI-EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAElAKIFSLLMMILAI-APALAP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 148 VV-QLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDRSVPEKNhnresqredcKQASPYSPLTKEctetrlccsl 226
Cdd:cd17320 141 LLgGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLS----------SLLRAYKRVLKN---------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 227 qqeyGFLLMSDFVVLAVSVLFMAY-GCSPlFVYLVPYalsvGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNyry 305
Cdd:cd17320 201 ----RRFLGYALALGLSFAGLFAYlAAAP-FIYIEQL----GLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR--- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 306 vCYLFAVALDGLCYLCLP------MLQTFPLLVPFSCTFgyfdGAYVTLIPVVTA-------EIVGTTslSSALGVVYFL 372
Cdd:cd17320 269 -LLRLGLLLLLAAALVLLlaallgGLSLWPLVAPLFLIF----FGFGLIFPNATSlalepfpHVAGTA--SALLGFLQFL 341
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 569007255 373 HAVPYLvspPIAGWLVDTT-GSYTAAFLLCGFAMIFSSILL 412
Cdd:cd17320 342 IGALAG---ALVGLLPNGTaLPMGLLILVLGLLALLLLILL 379
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
81-425 |
2.40e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 43.38 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 81 STGFILGSFATSLKHLYLSLgVLTGLGFALCYSPAIA-MVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWR 159
Cdd:PRK12307 94 SVGTGLSGLASGVIMLTLSR-FIVGMGMAGEYACASTyAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWR 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 160 GALLIlggfvlnlcvcGALMRPITLKEDRSVPEKNHNRESQREDCKQASPYSPLTKECTETRLccsLQQEYGFLLMSDFV 239
Cdd:PRK12307 173 AAFFV-----------GLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGL---FNRAQFPLTLCVFI 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 240 VLavsvlFMAYGCS-PLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLK---------NYRYVCYL 309
Cdd:PRK12307 239 VL-----FSIFGANwPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKktfsigllmSFLFIFPL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 310 FAVALDGLCYLCLpmlqtfpllvpfsCTFG--YFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWL 387
Cdd:PRK12307 314 FRIPQDNYLLLGA-------------CLFGlmATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWL 380
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 569007255 388 VDTTGSYTAAFLLCGFAMIFSSILLGFV---RIVKRMKRTQ 425
Cdd:PRK12307 381 GITMGLGAALTFIVAFWTATILLIIGLSipdRLKARRESFQ 421
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-179 |
2.81e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQA---GIMLGGLLASTGFILGSFATSlkhLYLSLGVLT--G 105
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTS---PVVAVILLSlaG 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007255 106 LGFALCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIGTFILAPVVQLLIEQF-SWRGALLILGGFvlnlCVCGALM 179
Cdd:cd17319 283 FGIGAASPVFWSLPADLLPGEAaATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAV----ALLAALL 354
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
240-412 |
7.44e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 240 VLAVSVLFMAYGCS---PLFVYLVPYALSVGVShhQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYryvcYLFAVALDG 316
Cdd:cd17329 3 VLLIGSFLNRLGFFmvwPFMAIYLHQQLGLSAS--IVGLVLALSAVAGIVASLIGGRLADRFGRKPV----MLAGLLLRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 317 LCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTtgSYTA 396
Cdd:cd17329 77 LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--SFRL 154
|
170
....*....|....*.
gi 569007255 397 AFLLCGFAMIFSSILL 412
Cdd:cd17329 155 LFLAAAVLFLLAALVL 170
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
239-415 |
8.80e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 8.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 239 VVLAVSVLFMAYGCSPLF-VYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNyryvCYLFAVALDGL 317
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWsVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR----VLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 318 CYLCLPMLQTFPLLVPFSCTFGYFDGA-YVTLIPVVT----AEIVGTtslssALGVVYFLHAVPYLVSPPIAGWLVDTTG 392
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGsFAVGIALVSkwfpPDRRGL-----ALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180
....*....|....*....|...
gi 569007255 393 sYTAAFLLCGFAMIFSSILLGFV 415
Cdd:COG2223 158 -WRNAFLILGILLLVVAVLAWLF 179
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-170 |
1.37e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 27 FFVEFQTYFaqDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLgVLTGL 106
Cdd:cd17324 223 PFLTDVPGF--SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL-VLWGL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007255 107 GFALCYSPAIAMVGKYFSRRKALAYGIAMS----GSGIGTFILApvvqLLIEQFSWRGALLILGGFVL 170
Cdd:cd17324 300 GFFAAHSALQTRVLRLAPEARGLASSLYLAaynlGGALGAALGG----LVLDHGGWAGVGWVGAALLL 363
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
239-407 |
1.59e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 239 VVLAVSVLFMAYGCSPLF-VYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRRClknyRYVCYLFAVALDG 316
Cdd:cd17369 230 LLLAIGLRLAENVLFYLFtTFALSYATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVG----RRPVYLAGALLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 317 LCYLCLPML----QTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPY-LVSPPIAGWLVDTT 391
Cdd:cd17369 306 LFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGgGFAPLIATALVAAT 385
|
170 180
....*....|....*....|...
gi 569007255 392 GS------YTAAF-LLCGFAMIF 407
Cdd:cd17369 386 GSwwpvalYLAALaVISLVAALF 408
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
274-433 |
2.92e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 274 AFLMSILGVIDIVGNITF----GWLTDRRCLKNYRYVCYLF-AVALDGLCYLCLPMLQTFPLLVPF----SCTFGYFDGA 344
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFspfaGVLADRFDRRRLLILADLLrALLAAVLALLALLGSLSLWLLLVLafllGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 345 YVTLIPvvtaEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVdTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRMKRT 424
Cdd:cd06173 113 RQALLP----ELVPKEQLVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
....*....
gi 569007255 425 QVPFPVKDS 433
Cdd:cd06173 188 ESSSLLLRD 196
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
31-411 |
3.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 31 FQTYFAQDYSQTAWIHSIvdcmTMLCAPLGSVVSNQLSCQAG---IMLGGLLAST-GFILGSFATSLKHLYLSLgVLTGL 106
Cdd:cd17504 22 IQREFGTSAAAVSWVLTA----YLLVGAVSTPILGRLGDLYGrkkVLLIVLAIYTaGSLLAAFAPNLPVLIAGR-ALQGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 107 GFALcySP-AIAMVGKYFSRRK-ALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITL 184
Cdd:cd17504 97 GGAV--FPlAFALVREEFPPERvPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 185 KEdRSVpeknhnresqredckqaspyspltkectetrlccslqqeygfLLMSDFVVLAVSVLFMAYGCSPLFVYLvPYAL 264
Cdd:cd17504 175 RR-RNV------------------------------------------LLANITALLAGFGMFMVFQLLPQLLQL-PTPT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 265 SVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclkNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGA 344
Cdd:cd17504 211 GFGLGITEAGLLLLPGALVMLIAGPLAGRLIARV---GPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGL 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007255 345 YVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAG------------WLVDTTGSYTAAFLLCGFAMIFSSIL 411
Cdd:cd17504 288 AFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGailttytvsitsGGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
73-416 |
4.57e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 73 IMLGGLLastGFILGSFATSLKHlylSLGVLT------GLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFIL 145
Cdd:cd17321 63 VFLIGLA---LFGLASLLCALAP---SLAFLIaaralqGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 146 APVVQLLIEQFSWRGAllilggFVLNLCVCGAlmrpitlkedrsvpeknhnresqredckqaspyspltkectetrlccs 225
Cdd:cd17321 137 PLLGGLLLELFGWRWI------FLINVPIGLV------------------------------------------------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 226 lqqeyGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHHQAAFLMSILGVIDIVGNITFGWLTDRrclKNYR 304
Cdd:cd17321 163 -----ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRLADR---FGPR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 305 YVCY--LFAVALDGLCYLCLPMLQTFPLLVPFSCTFG-----YFDGAYVTLIPVVTAE-------IVGTT-SLSSALGV- 368
Cdd:cd17321 235 LVLVagLLLTAVGLLLLALLGADSSVWLLLPGLVLLGlglglFATPLTNAALSSVPKEkagaasgILNTArQLGGALGVa 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 569007255 369 --------VYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVR 416
Cdd:cd17321 315 llgalltaGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
241-419 |
5.33e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 241 LAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRclknYRYVCYLFAVALDGLCYL 320
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF----GRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 321 CLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGsYTAAFLL 400
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIV 155
|
170
....*....|....*....
gi 569007255 401 CGFAMIFSSILLGFVRIVK 419
Cdd:cd17489 156 AAVLALLALLLVFLVKDPP 174
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
235-418 |
7.40e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.49 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 235 MSDFVVLAVSVLFMAYGCSPLFVYLVPYAL-----SVGVSHHQAAFLMS--ILGVIdiVGNITFGWLTDRRClknyRYVC 307
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAApaisaEWGLDPVQLGFLFSagLIGMA--FGALFFGPLADRIG----RRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007255 308 YLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWL 387
Cdd:TIGR00895 85 LLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180 190
....*....|....*....|....*....|.
gi 569007255 388 VDTTGsYTAAFLLCGfamIFSSILLGFVRIV 418
Cdd:TIGR00895 165 IPVFG-WRSLFYVGG---IAPLLLLLLLMRF 191
|
|
| |
