NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|569003806|ref|XP_006525971|]
View 

anion exchange protein 4 isoform X3 [Mus musculus]

Protein Classification

anion exchanger family transporter( domain architecture ID 705853)

anion exchanger family transporter similar to human SLC4 proteins which function as bicarbonate transporters

Gene Ontology:  GO:0005452|GO:0022857|GO:0055085
SCOP:  4003612
TCDB:  2.A.31

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
53-856 0e+00

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 681.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806   53 FIQLNELLGW-PQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVV- 130
Cdd:TIGR00834   1 FVELNELMLDrNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  131 ----SGEsLSPELRGQLQALLLQRPQHHIQTM---GIRPCR---------ESNAFRKASRDEDAPLKHQNPLR------- 187
Cdd:TIGR00834  81 hliySGQ-IRPEDRDEVLRALLLKHSHQSDAKklgGLSRARsqssigktlSHDASEMPNPDNGAPLLPHQPLTemqllsv 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  188 ---------------QKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEM 252
Cdd:TIGR00834 160 pgdigsreksklkflKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHEI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  253 GRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQ--HKRFPSKLQEVTSLSRQS 330
Cdd:TIGR00834 240 GRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQREllRKRYEPSTVRPENPTMGG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  331 AALAEDKHHHGPHTPIPELQRTGRTCAG--RHVG------------------------------TPVISW---------- 368
Cdd:TIGR00834 320 DTEPEDGGSEGPHGDDDPLQRTGRPFGGliRDIKrryphylsdftdalnpqclaavifiyfaalSPAITFggllgektrn 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  369 ----MPYTPSVSQLCSTFTWPQSQTPSLLG------VFWEMPLKVPRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLV 438
Cdd:TIGR00834 400 mmgvSELLISTAVQGVLFALLAAQPLLVVGfsgpllVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFLV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  439 RYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQrpgssaygcfcqypgtggntsewtsaKLKDTEDILSVQPGLVN 518
Cdd:TIGR00834 480 RYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQ--------------------------VFYNTLFCVPPKPQGPS 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  519 ASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTF 598
Cdd:TIGR00834 534 VSALLEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIF 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  599 LGLA-TPKLLVPTEFKPTLSG-RGWLVSPFGAN---PWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFH 673
Cdd:TIGR00834 614 IGDTyTQKLSVPSGLKVTNPSaRGWFIPPLGENrpfPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFH 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  674 LDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFI 753
Cdd:TIGR00834 694 LDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRI 773
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  754 PMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLML 833
Cdd:TIGR00834 774 PLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVL 853
                         890       900
                  ....*....|....*....|....
gi 569003806  834 LGLVAIRKALE-WVFSPQELLWLD 856
Cdd:TIGR00834 854 ILTVPLRRLLLpRLFTERELKCLD 877
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
53-856 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 681.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806   53 FIQLNELLGW-PQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVV- 130
Cdd:TIGR00834   1 FVELNELMLDrNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  131 ----SGEsLSPELRGQLQALLLQRPQHHIQTM---GIRPCR---------ESNAFRKASRDEDAPLKHQNPLR------- 187
Cdd:TIGR00834  81 hliySGQ-IRPEDRDEVLRALLLKHSHQSDAKklgGLSRARsqssigktlSHDASEMPNPDNGAPLLPHQPLTemqllsv 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  188 ---------------QKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEM 252
Cdd:TIGR00834 160 pgdigsreksklkflKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHEI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  253 GRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQ--HKRFPSKLQEVTSLSRQS 330
Cdd:TIGR00834 240 GRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQREllRKRYEPSTVRPENPTMGG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  331 AALAEDKHHHGPHTPIPELQRTGRTCAG--RHVG------------------------------TPVISW---------- 368
Cdd:TIGR00834 320 DTEPEDGGSEGPHGDDDPLQRTGRPFGGliRDIKrryphylsdftdalnpqclaavifiyfaalSPAITFggllgektrn 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  369 ----MPYTPSVSQLCSTFTWPQSQTPSLLG------VFWEMPLKVPRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLV 438
Cdd:TIGR00834 400 mmgvSELLISTAVQGVLFALLAAQPLLVVGfsgpllVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFLV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  439 RYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQrpgssaygcfcqypgtggntsewtsaKLKDTEDILSVQPGLVN 518
Cdd:TIGR00834 480 RYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQ--------------------------VFYNTLFCVPPKPQGPS 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  519 ASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTF 598
Cdd:TIGR00834 534 VSALLEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIF 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  599 LGLA-TPKLLVPTEFKPTLSG-RGWLVSPFGAN---PWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFH 673
Cdd:TIGR00834 614 IGDTyTQKLSVPSGLKVTNPSaRGWFIPPLGENrpfPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFH 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  674 LDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFI 753
Cdd:TIGR00834 694 LDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRI 773
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  754 PMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLML 833
Cdd:TIGR00834 774 PLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVL 853
                         890       900
                  ....*....|....*....|....
gi 569003806  834 LGLVAIRKALE-WVFSPQELLWLD 856
Cdd:TIGR00834 854 ILTVPLRRLLLpRLFTERELKCLD 877
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
405-809 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 571.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  405 RDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPgssaYGC 484
Cdd:pfam00955 104 KDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLIKIFKKYPLYLN----YDC 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  485 FCQYPGTGGNTSEWTSAKlkdtedilSVQPGLVNASFLPPPEC-IRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIAL 563
Cdd:pfam00955 180 TCVPPSSNNTTNSTLSLS--------TESSSINWSSLLTNSECtESYGGTLVGSGCGYVPDTALLSLILFLGTFWLAYFL 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  564 KHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALL 643
Cdd:pfam00955 252 KQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTRPDRGWIINPFGKNPWWLILAAILPALL 331
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  644 LSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNF 723
Cdd:pfam00955 332 VTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNSLKVESECVAPGEKPKI 411
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  724 LGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRV 803
Cdd:pfam00955 412 LGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFFDRILLLFMPQKHQPDTHYLRHVPLRKV 491

                  ....*.
gi 569003806  804 HLFTAI 809
Cdd:pfam00955 492 HLFTLI 497
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
53-856 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 681.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806   53 FIQLNELLGW-PQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVV- 130
Cdd:TIGR00834   1 FVELNELMLDrNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  131 ----SGEsLSPELRGQLQALLLQRPQHHIQTM---GIRPCR---------ESNAFRKASRDEDAPLKHQNPLR------- 187
Cdd:TIGR00834  81 hliySGQ-IRPEDRDEVLRALLLKHSHQSDAKklgGLSRARsqssigktlSHDASEMPNPDNGAPLLPHQPLTemqllsv 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  188 ---------------QKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEM 252
Cdd:TIGR00834 160 pgdigsreksklkflKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHEI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  253 GRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQ--HKRFPSKLQEVTSLSRQS 330
Cdd:TIGR00834 240 GRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQREllRKRYEPSTVRPENPTMGG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  331 AALAEDKHHHGPHTPIPELQRTGRTCAG--RHVG------------------------------TPVISW---------- 368
Cdd:TIGR00834 320 DTEPEDGGSEGPHGDDDPLQRTGRPFGGliRDIKrryphylsdftdalnpqclaavifiyfaalSPAITFggllgektrn 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  369 ----MPYTPSVSQLCSTFTWPQSQTPSLLG------VFWEMPLKVPRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLV 438
Cdd:TIGR00834 400 mmgvSELLISTAVQGVLFALLAAQPLLVVGfsgpllVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFLV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  439 RYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQrpgssaygcfcqypgtggntsewtsaKLKDTEDILSVQPGLVN 518
Cdd:TIGR00834 480 RYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQ--------------------------VFYNTLFCVPPKPQGPS 533
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  519 ASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTF 598
Cdd:TIGR00834 534 VSALLEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIF 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  599 LGLA-TPKLLVPTEFKPTLSG-RGWLVSPFGAN---PWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFH 673
Cdd:TIGR00834 614 IGDTyTQKLSVPSGLKVTNPSaRGWFIPPLGENrpfPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFH 693
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  674 LDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFI 753
Cdd:TIGR00834 694 LDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRI 773
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  754 PMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLML 833
Cdd:TIGR00834 774 PLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVL 853
                         890       900
                  ....*....|....*....|....
gi 569003806  834 LGLVAIRKALE-WVFSPQELLWLD 856
Cdd:TIGR00834 854 ILTVPLRRLLLpRLFTERELKCLD 877
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
405-809 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 571.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  405 RDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPgssaYGC 484
Cdd:pfam00955 104 KDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLIKIFKKYPLYLN----YDC 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  485 FCQYPGTGGNTSEWTSAKlkdtedilSVQPGLVNASFLPPPEC-IRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIAL 563
Cdd:pfam00955 180 TCVPPSSNNTTNSTLSLS--------TESSSINWSSLLTNSECtESYGGTLVGSGCGYVPDTALLSLILFLGTFWLAYFL 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  564 KHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALL 643
Cdd:pfam00955 252 KQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTRPDRGWIINPFGKNPWWLILAAILPALL 331
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  644 LSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNF 723
Cdd:pfam00955 332 VTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNSLKVESECVAPGEKPKI 411
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  724 LGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRV 803
Cdd:pfam00955 412 LGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFFDRILLLFMPQKHQPDTHYLRHVPLRKV 491

                  ....*.
gi 569003806  804 HLFTAI 809
Cdd:pfam00955 492 HLFTLI 497
Band_3_cyto pfam07565
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
84-293 2.77e-38

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


Pssm-ID: 429542  Cd Length: 255  Bit Score: 143.63  E-value: 2.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806   84 GAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLE----LVEQVVSGESLSPELRGQ-LQALLLQ--------- 149
Cdd:pfam07565   5 EGGRWGKPHVATLSFHSLLELRRCLAKGTVLLDLEATSLPGvahlVLDQMIYSGQIRPEDREEvLRALLLKhshqnelke 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  150 ---------------------------RPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAG 202
Cdd:pfam07565  85 lggvkpavrslssigsslshghddskpLLPQQSSLEGGLLCEQGEGPNSDEQLTVSESKSPLHFLKKIPEDAEATNVLVG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003806  203 ELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAAL 282
Cdd:pfam07565 165 EVDFLERPVLAFVRLKEAVPLEGVTEVPVPVRFLFILLGPSGPGLDYHEIGRAIATLMSDEVFHDVAYKADDREDLLAGI 244
                         250
                  ....*....|.
gi 569003806  283 DAFLQEVTALP 293
Cdd:pfam07565 245 DEFLDCSIVLP 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH