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Conserved domains on  [gi|569003682|ref|XP_006525910|]
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WD repeat-containing protein 36 isoform X1 [Mus musculus]

Protein Classification

WD40 and Utp21 domain-containing protein( domain architecture ID 11456778)

WD40 and Utp21 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 693-873 3.83e-59

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 200.45  E-value: 3.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  693 EQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVP------EPSSDPQQSKVVNL 766
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  767 GILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLspDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLA 846
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180
                  ....*....|....*....|....*....
gi 569003682  847 LFLKLHLRTLPSEP--ALLEELVKLSSQL 873
Cdd:pfam04192 159 VFLKLHGDVIHSNEeeELREALEEWKSVQ 187
WD40 COG2319
WD40 repeat [General function prediction only];
167-640 2.67e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 247 DGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHS 326
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL------------------ 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAH 486
Cdd:COG2319  189 -------------WDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGH 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319  246 SGSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569003682 564 REFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWS 640
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 693-873 3.83e-59

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 200.45  E-value: 3.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  693 EQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVP------EPSSDPQQSKVVNL 766
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  767 GILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLspDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLA 846
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180
                  ....*....|....*....|....*....
gi 569003682  847 LFLKLHLRTLPSEP--ALLEELVKLSSQL 873
Cdd:pfam04192 159 VFLKLHGDVIHSNEeeELREALEEWKSVQ 187
WD40 COG2319
WD40 repeat [General function prediction only];
167-640 2.67e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 247 DGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHS 326
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL------------------ 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAH 486
Cdd:COG2319  189 -------------WDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGH 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319  246 SGSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569003682 564 REFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWS 640
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-598 7.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 7.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 279 HSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHSASLTKIRYYGqNGQQILSASQDGTLQSFSTVH 358
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 359 EKFNKSL-GHglvnkkivkrkgLQNTMSVRLPPITQFAAeearQSDWDGIIACHQGK--RSCSTWNYQRSTIgayflkpr 435
Cdd:cd00200   83 GECVRTLtGH------------TSYVSSVAFSPDGRILS----SSSRDKTIKVWDVEtgKCLTTLRGHTDWV-------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 436 gvktnsnltaTAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWN 515
Cdd:cd00200  139 ----------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 516 FKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSV 594
Cdd:cd00200  206 LSTGKCLGTLrGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 569003682 595 RTWD 598
Cdd:cd00200  286 RIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 559-598 5.81e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.81e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 569003682   559 TRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWD 598
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
560-598 1.07e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569003682  560 RKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWD 598
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 491-629 2.57e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 47.34  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  491 RGVAV--DGlNQLVVTAGSERLLKFWNFKSKVLIHSLGLDSSPNMMLLHRDSGILGLA-MDDFSIAVLDIETRKIVrefs 567
Cdd:TIGR03866  44 RGITFskDG-KLLYVCASDSDTIQVIDPATGEVLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL---- 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569003682  568 ghhGQIN------DMTFSPDGRWLISAAMDCSVRTW-DLPSGCLIDCFLLDSAPLNVTMSPTGDFLATS 629
Cdd:TIGR03866 119 ---AQIDvgvepeGMAVSPDGKIVVNTSETTNMAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 693-873 3.83e-59

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 200.45  E-value: 3.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  693 EQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVP------EPSSDPQQSKVVNL 766
Cdd:pfam04192   1 DQLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVGDFASVeaqeeeEEEEEEERSRLLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  767 GILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLspDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLA 846
Cdd:pfam04192  81 GSLGFESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSL--NSGGPLEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180
                  ....*....|....*....|....*....
gi 569003682  847 LFLKLHLRTLPSEP--ALLEELVKLSSQL 873
Cdd:pfam04192 159 VFLKLHGDVIHSNEeeELREALEEWKSVQ 187
WD40 COG2319
WD40 repeat [General function prediction only];
167-640 2.67e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 247 DGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHS 326
Cdd:COG2319   89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319  163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL------------------ 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAH 486
Cdd:COG2319  189 -------------WDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGH 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319  246 SGSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569003682 564 REFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWS 640
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGSADG-TVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
167-601 3.53e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.53e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319  131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319  205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319  231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319  288 SGGVNSVAFspDG--KLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 569003682 564 REFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPS 601
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-598 7.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 7.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 279 HSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHSASLTKIRYYGqNGQQILSASQDGTLQSFSTVH 358
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 359 EKFNKSL-GHglvnkkivkrkgLQNTMSVRLPPITQFAAeearQSDWDGIIACHQGK--RSCSTWNYQRSTIgayflkpr 435
Cdd:cd00200   83 GECVRTLtGH------------TSYVSSVAFSPDGRILS----SSSRDKTIKVWDVEtgKCLTTLRGHTDWV-------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 436 gvktnsnltaTAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWN 515
Cdd:cd00200  139 ----------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 516 FKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSV 594
Cdd:cd00200  206 LSTGKCLGTLrGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 569003682 595 RTWD 598
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
445-665 2.65e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 2.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 445 ATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLI 522
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFspDG--KTLASGSADGTVRLWDLATGKLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 523 HSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPS 601
Cdd:COG2319  156 RTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003682 602 GCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWsNISLYSVVSLRPLPPDYVPSIVMLP 665
Cdd:COG2319  236 GKLLRTLTGHSGSVRsVAFSPDGRLLASGSADG-TVRLW-DLATGELLRTLTGHSGGVNSVAFSP 298
WD40 COG2319
WD40 repeat [General function prediction only];
96-352 9.69e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 9.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  96 ARNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKIStiLHPStylNKVLL-GS 171
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVA--FSPD---GKLLAsGS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 172 EQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHPI 251
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 252 MAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHSASLTK 331
Cdd:COG2319  304 ASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTS 377

                        250       260
                 ....*....|....*....|.
gi 569003682 332 IRYyGQNGQQILSASQDGTLQ 352
Cdd:COG2319  378 VAF-SPDGRTLASGSADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-367 1.50e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 102 VHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKISTILHpSTYLnkvLLGSEQGSLQL 178
Cdd:cd00200    2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD-GTYL---ASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 179 WNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKF--HQDWgpITSISFRTDGHpIMAAGS 256
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrgHTDW--VNSVAFSPDGT-FVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 257 PCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDgpagEGRLLRFRMGHSASLTKIRYyG 336
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-S 228

                        250       260       270
                 ....*....|....*....|....*....|..
gi 569003682 337 QNGQQILSASQDGTLQSFSTVHEKFNKSL-GH 367
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-351 2.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 2.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  74 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQL 145
Cdd:cd00200   12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 146 T-FDKSVFKIStiLHPSTYLnkVLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIK 224
Cdd:cd00200   90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 225 YDETLMKF--HQDWgpITSISFRTDGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADN 302
Cdd:cd00200  166 TGKCVATLtgHTGE--VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 569003682 303 ALRIWifDGPAGEgRLLRFRmGHSASLTKIRYYGqNGQQILSASQDGTL 351
Cdd:cd00200  242 TIRVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 446-640 7.92e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 7.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 446 TAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL 525
Cdd:cd00200   55 RDVAASADGTYLASGSSDKTIRLWDLETGECVRTL---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 526 -GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCL 604
Cdd:cd00200  132 rGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569003682 605 IDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWS 640
Cdd:cd00200  212 LGTLRGHENGVNsVAFSPDGYLLASGSEDG-TIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-640 4.35e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 4.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 484 KAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKI 562
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569003682 563 VREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHLgIYLWS 640
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNsVAFSPDGTFVASSSQDGT-IKLWD 163
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 446-640 5.75e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 5.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 446 TAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL 525
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 526 -GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCL 604
Cdd:cd00200   90 tGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569003682 605 IDCFLLDSAPLN-VTMSPTGDFLATSHVDHLgIYLWS 640
Cdd:cd00200  170 VATLTGHTGEVNsVAFSPDGEKLLSSSSDGT-IKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
79-307 4.53e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 4.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  79 ADGRLVFAAYGN----VFSAfaRNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLTF-DKSV 151
Cdd:COG2319  172 PDGKLLASGSDDgtvrLWDL--ATGKLLRTLTGHTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 152 FKIStiLHPStylNKVLL-GSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLM 230
Cdd:COG2319  250 RSVA--FSPD---GRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569003682 231 KFHQDWGPITSISFRTDGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-307 4.63e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 4.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  97 RNKEIVHTFKGHKAEIH--LLQPFGDHVISVDTDSVLIIWHIysEEEYLQLTFD---KSVFKIStiLHPStylNKVLLGS 171
Cdd:cd00200   81 ETGECVRTLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVASS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 172 EQ-GSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHp 250
Cdd:cd00200  154 SQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY- 232

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569003682 251 IMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
498-640 3.47e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 3.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 498 LNQLVVTAGSERLLKFWNFKSKVLIHSLGLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDMT 577
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003682 578 FSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLN-VTMSPTGDFLATSHVDHlGIYLWS 640
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRsVAFSPDGKTLASGSADG-TVRLWD 148
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 563-640 5.80e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 5.80e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569003682 563 VREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLNVTM-SPTGDFLATSHVDHLgIYLWS 640
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTYLASGSSDKT-IRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 559-598 5.81e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.81e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 569003682   559 TRKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWD 598
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
560-598 1.07e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569003682  560 RKIVREFSGHHGQINDMTFSPDGRWLISAAMDCSVRTWD 598
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
444-626 1.55e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 444 TATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDDKAHTGSVRGVAVDGLNQLVVTAGSERLLKFwNFKSKVLIH 523
Cdd:COG3391   26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVI-DLATGKVVA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682 524 SLGLDSSPNMMLLHRDSGILGLA-MDDFSIAVLDIETRKIVREFSGhHGQINDMTFSPDGRWLISAAMDCS-----VRTW 597
Cdd:COG3391  105 TIPVGGGPRGLAVDPDGGRLYVAdSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRLYVANSGSNtvsviVSVI 183

                        170       180
                 ....*....|....*....|....*....
gi 569003682 598 DLPSGCLIDCFLLDSAPLNVTMSPTGDFL 626
Cdd:COG3391  184 DTATGKVVATIPVGGGPVGVAVSPDGRRL 212
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 491-629 2.57e-05

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 47.34  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  491 RGVAV--DGlNQLVVTAGSERLLKFWNFKSKVLIHSLGLDSSPNMMLLHRDSGILGLA-MDDFSIAVLDIETRKIVrefs 567
Cdd:TIGR03866  44 RGITFskDG-KLLYVCASDSDTIQVIDPATGEVLHTLPSGPDPEQFALHPNGKILYIAnEDDALVTVIDIETRKVL---- 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569003682  568 ghhGQIN------DMTFSPDGRWLISAAMDCSVRTW-DLPSGCLIDCFLLDSAPLNVTMSPTGDFLATS 629
Cdd:TIGR03866 119 ---AQIDvgvepeGMAVSPDGKIVVNTSETTNMAHWiDTATYEIVDNTLVDARPRFAEFTADGKELWVS 184
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 204-288 1.83e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003682  204 PAVDVVAIGLVSGQVVIHNIkydetlmKFHQDWG--------PITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQm 275
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRL-------NWQRVWTlspdkedlEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH- 75

                          90
                  ....*....|...
gi 569003682  276 RNAHSTAISGLTF 288
Cdd:pfam12894  76 FSAGSDLITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 548-585 1.55e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 42.33  E-value: 1.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569003682  548 DDFSIAVLDIET---RKIVRefSGHHGQINDMTFSPDGRWL 585
Cdd:COG4946   408 NRGRLWVVDLASgkvRKVDT--DGYGDGISDLAWSPDSKWL 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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