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Conserved domains on  [gi|569003077|ref|XP_006525616|]
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cadherin-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 236-341 4.25e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 236 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 315
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 569003077 316 DMEGNPtygLSNTATAVITVTDVNDN 341
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-865 5.05e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 5.05e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  806 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYG 865
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 19-84 2.92e-24

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 97.40  E-value: 2.92e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569003077   19 LQVKFSNCNRKRKVQYESSEPaDFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNL 84
Cdd:pfam08758  26 LNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-564 8.42e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 471 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 549
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 569003077 550 GTGTLQIYLLDINDN 564
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-226 3.12e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 86.24  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 126 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 569003077 206 NGNQVENPIDIVINVIDMNDN 226
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-457 5.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 349 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 427
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 569003077 428 ENQVplakgiQHPPQSTATVSVTVIDVNEN 457
Cdd:cd11304   75 TDGG------GPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 571-664 2.55e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  571 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 646
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 569003077  647 DSGNPPKSNISILRVKVC 664
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 236-341 4.25e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 236 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 315
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 569003077 316 DMEGNPtygLSNTATAVITVTDVNDN 341
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-865 5.05e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 5.05e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  806 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYG 865
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 19-84 2.92e-24

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 97.40  E-value: 2.92e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569003077   19 LQVKFSNCNRKRKVQYESSEPaDFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNL 84
Cdd:pfam08758  26 LNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
Cadherin pfam00028
Cadherin domain;
236-336 1.02e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  236 NGSVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRILSQapstPSPNMFTINNETGDiITVAAGLDREKVQQYTLIIQAT 315
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGD-ISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 569003077  316 DmegNPTYGLSNTATAVITVT 336
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 253-343 1.46e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   253 TAIDADDPNalNGMLRYRILSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 332
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 569003077   333 ITVTDVNDNPP 343
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-564 8.42e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 471 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 549
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 569003077 550 GTGTLQIYLLDINDN 564
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
467-559 4.75e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  467 IRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 545
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 569003077  546 PPMSGTGTLQIYLL 559
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 19-82 7.78e-22

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 90.42  E-value: 7.78e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003077    19 LQVKFSNCNRKRKVQYESSEPaDFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAV 82
Cdd:smart01055  25 GRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEIKV 87
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-226 3.12e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 86.24  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 126 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 569003077 206 NGNQVENPIDIVINVIDMNDN 226
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-457 5.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 349 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 427
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 569003077 428 ENQVplakgiQHPPQSTATVSVTVIDVNEN 457
Cdd:cd11304   75 TDGG------GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 483-566 2.32e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   483 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 561
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 569003077   562 NDNAP 566
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
350-452 7.67e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 7.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  350 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 428
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 569003077  429 NQVPlakgiqHPPQSTATVSVTVI 452
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-228 1.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   148 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 227
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 569003077   228 P 228
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-458 1.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   367 TVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 446
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 569003077   447 VSVTVIDVNENP 458
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
127-221 2.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  127 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 569003077  206 NGNQVENPIDIVINVI 221
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
571-664 2.55e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  571 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 646
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 569003077  647 DSGNPPKSNISILRVKVC 664
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 236-341 4.25e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 236 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 315
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 569003077 316 DMEGNPtygLSNTATAVITVTDVNDN 341
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-865 5.05e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 104.16  E-value: 5.05e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  806 ADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYG 865
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 19-84 2.92e-24

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 97.40  E-value: 2.92e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569003077   19 LQVKFSNCNRKRKVQYESSEPaDFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNL 84
Cdd:pfam08758  26 LNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
Cadherin pfam00028
Cadherin domain;
236-336 1.02e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  236 NGSVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRILSQapstPSPNMFTINNETGDiITVAAGLDREKVQQYTLIIQAT 315
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGD-ISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 569003077  316 DmegNPTYGLSNTATAVITVT 336
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 253-343 1.46e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   253 TAIDADDPNalNGMLRYRILSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 332
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
gi 569003077   333 ITVTDVNDNPP 343
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-564 8.42e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 8.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 471 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 549
Cdd:cd11304    8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 569003077 550 GTGTLQIYLLDINDN 564
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
467-559 4.75e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  467 IRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 545
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 569003077  546 PPMSGTGTLQIYLL 559
Cdd:pfam00028  79 PPLSSTATVTITVL 92
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 19-82 7.78e-22

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 90.42  E-value: 7.78e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003077    19 LQVKFSNCNRKRKVQYESSEPaDFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAV 82
Cdd:smart01055  25 GRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEIKV 87
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-226 3.12e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 86.24  E-value: 3.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 126 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:cd00031    1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 569003077 206 NGNQVENPIDIVINVIDMNDN 226
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-457 5.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 349 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 427
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 569003077 428 ENQVplakgiQHPPQSTATVSVTVIDVNEN 457
Cdd:cd11304   75 TDGG------GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 483-566 2.32e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 2.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   483 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 561
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 569003077   562 NDNAP 566
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
350-452 7.67e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 7.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  350 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 428
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 569003077  429 NQVPlakgiqHPPQSTATVSVTVI 452
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 129-226 1.55e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077 129 INLPENSrgPFPQELVRIR-SDRDK--NLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:cd11304    4 VSVPENA--PPGTVVLTVSaTDPDSgeNGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 569003077 206 NGNQVENPIDIVINVIDMNDN 226
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-228 1.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   148 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 227
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 569003077   228 P 228
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-458 1.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077   367 TVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 446
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
gi 569003077   447 VSVTVIDVNENP 458
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
127-221 2.41e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  127 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 205
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 569003077  206 NGNQVENPIDIVINVI 221
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
571-664 2.55e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003077  571 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 646
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 569003077  647 DSGNPPKSNISILRVKVC 664
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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