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Conserved domains on  [gi|569003037|ref|XP_006525596|]
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adenomatous polyposis coli protein isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 728-1015 2.87e-157

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 488.33  E-value: 2.87e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   728 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYAFDANRHDDS-- 805
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   806 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLSAYHPTTENAGTSSKR-GLQITTTAAQ 882
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   883 IAKVMEEVSAIHTSQDDRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSNDSLNS 962
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 569003037   963 VTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1015
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2221-2566 2.22e-95

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 312.58  E-value: 2.22e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2221 SISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTS-PRGTKPAGKSELSPITRQTSQISGSNKGSSR 2299
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2300 SGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQLSQQNLTKQ 2379
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2380 ASLSKNASSI------PRSESASKGLNqmsngNGSNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRK 2453
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2454 LEESASfESLSPSSRPDSPTRSQaqtpvlsPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSES 2533
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 569003037  2534 PSRLPInRAGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding super family cl05480
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2840 4.06e-76

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


The actual alignment was detected with superfamily member pfam05937:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 250.68  E-value: 4.06e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2668 RSGRSPTGNTPPVIDSVSEKGSSSIKDSKDTHGKQSVGSGS-PVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIA 2746
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNvPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2747 ETAETCIAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTDSTESSGAQ 2826
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 569003037  2827 SPKRHSGSYLVTSV 2840
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1032-1131 3.07e-54

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 185.11  E-value: 3.07e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1032 LNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENTDDKHLKFQPHFGQQECVSPYRSRGTSGSETNRM 1111
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 569003037  1112 GSSHAINQNVNQSLCQEDDY 1131
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 371-444 1.98e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.78  E-value: 1.98e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003037   371 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 444
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1742-1835 7.91e-42

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 149.22  E-value: 7.91e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1742 IMDQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKPSLQTNAKAFNE 1821
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 569003037  1822 KLPNNEDRVRGSFA 1835
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1279-1365 7.48e-31

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 117.67  E-value: 7.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1279 ADDEI-GCDQTTQEADSANTLQTAEVKENDVTRSAEDPATEVPAVSQNARAKPSRLQASGLS-SESTRHnKAVEFSSGAK 1356
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRH-KAVEFSSGAK 80


                   ....*....
gi 569003037  1357 SPSKSGAQT 1365
Cdd:pfam16633   81 SPSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1869-1943 1.07e-30

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 116.88  E-value: 1.07e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003037  1869 DLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1658-1711 5.23e-25

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 99.87  E-value: 5.23e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 569003037  1658 IESPPNELATGDGVRAGIQSGEFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDD 1711
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 105-185 5.86e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 91.93  E-value: 5.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   105 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 183
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 569003037   184 TC 185
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1633-1656 2.21e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 2.21e-07
                           10        20
                   ....*....|....*....|....
gi 569003037  1633 DVPRVYCVEGTPINFSTATSLSDL 1656
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-685 4.60e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.60e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569003037    645 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 685
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 9.89e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.89e-06
                           10        20
                   ....*....|....*....|
gi 569003037  2030 DSEDDLLQECISSAMPKKKR 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 508-549 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569003037    508 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 549
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 687-727 6.99e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   687 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 727
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1712-1733 1.43e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|..
gi 569003037  1712 NKAEEGDILAECINSAMPKGKS 1733
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 318-370 8.10e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.10e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 569003037    318 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 370
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1253-1270 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 569003037  1253 ETIQTYCVEDTPICFSRC 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 728-1015 2.87e-157

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 488.33  E-value: 2.87e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   728 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYAFDANRHDDS-- 805
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   806 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLSAYHPTTENAGTSSKR-GLQITTTAAQ 882
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   883 IAKVMEEVSAIHTSQDDRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSNDSLNS 962
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 569003037   963 VTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1015
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2221-2566 2.22e-95

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 312.58  E-value: 2.22e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2221 SISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTS-PRGTKPAGKSELSPITRQTSQISGSNKGSSR 2299
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2300 SGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQLSQQNLTKQ 2379
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2380 ASLSKNASSI------PRSESASKGLNqmsngNGSNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRK 2453
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2454 LEESASfESLSPSSRPDSPTRSQaqtpvlsPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSES 2533
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 569003037  2534 PSRLPInRAGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2840 4.06e-76

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 250.68  E-value: 4.06e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2668 RSGRSPTGNTPPVIDSVSEKGSSSIKDSKDTHGKQSVGSGS-PVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIA 2746
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNvPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2747 ETAETCIAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTDSTESSGAQ 2826
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 569003037  2827 SPKRHSGSYLVTSV 2840
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1032-1131 3.07e-54

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 185.11  E-value: 3.07e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1032 LNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENTDDKHLKFQPHFGQQECVSPYRSRGTSGSETNRM 1111
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 569003037  1112 GSSHAINQNVNQSLCQEDDY 1131
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 371-444 1.98e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.78  E-value: 1.98e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003037   371 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 444
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1742-1835 7.91e-42

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 149.22  E-value: 7.91e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1742 IMDQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKPSLQTNAKAFNE 1821
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 569003037  1822 KLPNNEDRVRGSFA 1835
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1279-1365 7.48e-31

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 117.67  E-value: 7.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1279 ADDEI-GCDQTTQEADSANTLQTAEVKENDVTRSAEDPATEVPAVSQNARAKPSRLQASGLS-SESTRHnKAVEFSSGAK 1356
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRH-KAVEFSSGAK 80


                   ....*....
gi 569003037  1357 SPSKSGAQT 1365
Cdd:pfam16633   81 SPSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1869-1943 1.07e-30

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 116.88  E-value: 1.07e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003037  1869 DLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1658-1711 5.23e-25

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 99.87  E-value: 5.23e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 569003037  1658 IESPPNELATGDGVRAGIQSGEFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDD 1711
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 105-185 5.86e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 91.93  E-value: 5.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   105 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 183
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 569003037   184 TC 185
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1633-1656 2.21e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 2.21e-07
                           10        20
                   ....*....|....*....|....
gi 569003037  1633 DVPRVYCVEGTPINFSTATSLSDL 1656
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-685 4.60e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.60e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569003037    645 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 685
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-685 6.25e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   645 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 685
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2199-2562 3.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2199 GKIRSNSEISSQMKQPLPTNMPSISRGrtmihiPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSP-----RGTK 2273
Cdd:PHA03247 2659 GRVSRPRRARRLGRAAQASSPPQRPRR------RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPgpaaaRQAS 2732

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2274 PAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTqqPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAS 2353
Cdd:PHA03247 2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA--PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2354 TKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESAskglnqmsnGNGSNKKVELSRMSSTKSSGSESDRSERP 2433
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL---------GGSVAPGGDVRRRPPSRSPAAKPAAPARP 2881

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2434 ALVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAggwrKLPPNLSPT 2512
Cdd:PHA03247 2882 PVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPA 2950

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2513 ieyNDGRPTKRHDIARSHSESPSRLPINRAGTWK----RE------HSKHSSSLPRVSTW 2562
Cdd:PHA03247 2951 ---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTGHSLSRVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 9.89e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.89e-06
                           10        20
                   ....*....|....*....|
gi 569003037  2030 DSEDDLLQECISSAMPKKKR 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
112-225 6.24e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  112 LEELEKERSLLLADLDKEEKEKDWYY---------AQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQL 182
Cdd:COG4717   104 LEELEAELEELREELEKLEKLLQLLPlyqelealeAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELL 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 569003037  183 -GTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQ 225
Cdd:COG4717   184 eQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEE 227
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 508-549 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569003037    508 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 549
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 112-221 5.71e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   112 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSL------------PLTENFSLQTDMTRRQLEYEARQIRAAME 179
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqlleelnkkikDLGEEEQLRVKEKIGELEAEIASLERSIA 311

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 569003037   180 EQLGTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEAE 221
Cdd:TIGR02169  312 EKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRD 353
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 508-548 6.03e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   508 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 548
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 687-727 6.99e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   687 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 727
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1712-1733 1.43e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|..
gi 569003037  1712 NKAEEGDILAECINSAMPKGKS 1733
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 318-370 8.10e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.10e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 569003037    318 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 370
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1253-1270 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 569003037  1253 ETIQTYCVEDTPICFSRC 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 728-1015 2.87e-157

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 488.33  E-value: 2.87e-157
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   728 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYAFDANRHDDS-- 805
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   806 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLSAYHPTTENAGTSSKR-GLQITTTAAQ 882
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   883 IAKVMEEVSAIHTSQDDRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSNDSLNS 962
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 569003037   963 VTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1015
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2221-2566 2.22e-95

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 312.58  E-value: 2.22e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2221 SISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTS-PRGTKPAGKSELSPITRQTSQISGSNKGSSR 2299
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2300 SGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQLSQQNLTKQ 2379
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2380 ASLSKNASSI------PRSESASKGLNqmsngNGSNKKVELSRMSSTKSSGSESDRSerpALVRQSTFIKEAPSPTLRRK 2453
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2454 LEESASfESLSPSSRPDSPTRSQaqtpvlsPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSES 2533
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 569003037  2534 PSRLPInRAGTWKREHSKHSSSLPRVSTWRRTG 2566
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2840 4.06e-76

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 250.68  E-value: 4.06e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2668 RSGRSPTGNTPPVIDSVSEKGSSSIKDSKDTHGKQSVGSGS-PVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIA 2746
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNvPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  2747 ETAETCIAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTDSTESSGAQ 2826
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 569003037  2827 SPKRHSGSYLVTSV 2840
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1032-1131 3.07e-54

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 185.11  E-value: 3.07e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1032 LNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENTDDKHLKFQPHFGQQECVSPYRSRGTSGSETNRM 1111
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 569003037  1112 GSSHAINQNVNQSLCQEDDY 1131
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 371-444 1.98e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.78  E-value: 1.98e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003037   371 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 444
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1742-1835 7.91e-42

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 149.22  E-value: 7.91e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1742 IMDQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKPSLQTNAKAFNE 1821
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 569003037  1822 KLPNNEDRVRGSFA 1835
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1279-1365 7.48e-31

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 117.67  E-value: 7.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  1279 ADDEI-GCDQTTQEADSANTLQTAEVKENDVTRSAEDPATEVPAVSQNARAKPSRLQASGLS-SESTRHnKAVEFSSGAK 1356
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRH-KAVEFSSGAK 80


                   ....*....
gi 569003037  1357 SPSKSGAQT 1365
Cdd:pfam16633   81 SPSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1869-1943 1.07e-30

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 116.88  E-value: 1.07e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003037  1869 DLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1658-1711 5.23e-25

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 99.87  E-value: 5.23e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 569003037  1658 IESPPNELATGDGVRAGIQSGEFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDD 1711
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 105-185 5.86e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 91.93  E-value: 5.86e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   105 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 183
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 569003037   184 TC 185
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1633-1656 2.21e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 2.21e-07
                           10        20
                   ....*....|....*....|....
gi 569003037  1633 DVPRVYCVEGTPINFSTATSLSDL 1656
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-685 4.60e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.60e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569003037    645 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 685
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-685 6.25e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   645 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 685
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2199-2562 3.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2199 GKIRSNSEISSQMKQPLPTNMPSISRGrtmihiPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSP-----RGTK 2273
Cdd:PHA03247 2659 GRVSRPRRARRLGRAAQASSPPQRPRR------RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPgpaaaRQAS 2732

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2274 PAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTqqPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAS 2353
Cdd:PHA03247 2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA--PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2354 TKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESAskglnqmsnGNGSNKKVELSRMSSTKSSGSESDRSERP 2433
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL---------GGSVAPGGDVRRRPPSRSPAAKPAAPARP 2881

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2434 ALVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAggwrKLPPNLSPT 2512
Cdd:PHA03247 2882 PVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPA 2950

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2513 ieyNDGRPTKRHDIARSHSESPSRLPINRAGTWK----RE------HSKHSSSLPRVSTW 2562
Cdd:PHA03247 2951 ---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTGHSLSRVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 9.89e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.89e-06
                           10        20
                   ....*....|....*....|
gi 569003037  2030 DSEDDLLQECISSAMPKKKR 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2247-2542 2.34e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2247 KGPPLKTPASKSPSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSR---PTQQPLSRPMQSPG 2323
Cdd:PHA03307  101 AREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAsdaASSRQAALPLSSPE 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2324 RNSISPGRNGISPPNKLSQLPRTSSP----STASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSE----SA 2395
Cdd:PHA03307  181 ETARAPSSPPAEPPPSTPPAAASPRPprrsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplpRP 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2396 SKGLNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQStfiKEAPSPTLRRKLEESASFESLSPSSRPDSPTRS 2475
Cdd:PHA03307  261 APITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPG---SGPAPSSPRASSSSSSSRESSSSSTSSSSESSR 337

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003037 2476 QAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEY---NDGRPT---KRHDIARSH--SESPSRLPINRA 2542
Cdd:PHA03307  338 GAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSpaaSAGRPTrrrARAAVAGRArrRDATGRFPAGRP 412
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
112-225 6.24e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  112 LEELEKERSLLLADLDKEEKEKDWYY---------AQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQL 182
Cdd:COG4717   104 LEELEAELEELREELEKLEKLLQLLPlyqelealeAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELL 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 569003037  183 -GTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQ 225
Cdd:COG4717   184 eQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEE 227
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 113-240 1.08e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  113 EELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslQTDMTRRQLEYE-ARQIRAAMEEQLgtcQDMEKR 191
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEEL--------EAELAELEAELEeLRLELEELELEL---EEAQAE 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 569003037  192 AQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQSRHDAASHEAGRQHE 240
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE 338
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 508-549 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569003037    508 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 549
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 112-221 5.71e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   112 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSL------------PLTENFSLQTDMTRRQLEYEARQIRAAME 179
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqlleelnkkikDLGEEEQLRVKEKIGELEAEIASLERSIA 311

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 569003037   180 EQLGTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEAE 221
Cdd:TIGR02169  312 EKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRD 353
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 508-548 6.03e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   508 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 548
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 687-727 6.99e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 569003037   687 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 727
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2246-2487 1.10e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.68  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2246 KKGP-----PLKTPASKSPSEGPGATTSPRGTKPAGKSElSPITRQtsqisgsnkgssrsgsRDSTPSRPTQQPLSRPMQ 2320
Cdd:PTZ00449  560 KPGPakehkPSKIPTLSKKPEFPKDPKHPKDPEEPKKPK-RPRSAQ----------------RPTRPKSPKLPELLDIPK 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2321 SPGRNSISPGRNGISPPNKLSQLPRTSSP-STASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNA-SSIPRSESASKG 2398
Cdd:PTZ00449  623 SPKRPESPKSPKRPPPPQRPSSPERPEGPkIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETkTTVVLDESFESI 702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2399 LNQMSNGNGSNKKVE-------LSRMSSTKSSGSESDRSERPALVR-------QSTFIKEAPSPTLRRKL------EESA 2458
Cdd:PTZ00449  703 LKETLPETPGTPFTTprplppkLPRDEEFPFEPIGDPDAEQPDDIEfftppeeERTFFHETPADTPLPDIlaeefkEEDI 782

                         250       260       270
                  ....*....|....*....|....*....|..
gi 569003037 2459 SFESLSPSS---RPDSPTRSQAQTPVLSPSLP 2487
Cdd:PTZ00449  783 HAETGEPDEamkRPDSPSEHEDKPPGDHPSLP 814
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2252-2543 1.22e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2252 KTPASKSPSEG---PGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSIS 2328
Cdd:PHA03307   59 AAACDRFEPPTgppPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEML 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2329 PGRNGISPPNKLSQLPRTSSPS-TASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRS---------ESASKG 2398
Cdd:PHA03307  139 RPVGSPGPPPAASPPAAGASPAaVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASprpprrsspISASAS 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2399 LNQMSNGNGSNKKVELSRMSSTKSSGSESDRSER-------PALVRQSTFIKEAPSPTLRRKL----EESASFESLSPSS 2467
Cdd:PHA03307  219 SPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEnecplprPAPITLPTRIWEASGWNGPSSRpgpaSSSSSPRERSPSP 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2468 RPDSPTRSQAQTP-------------VLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKR----HDIARSH 2530
Cdd:PHA03307  299 SPSSPGSGPAPSSprasssssssresSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKrprpSRAPSSP 378

                         330
                  ....*....|...
gi 569003037 2531 SESPSRLPINRAG 2543
Cdd:PHA03307  379 AASAGRPTRRRAR 391
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1712-1733 1.43e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|..
gi 569003037  1712 NKAEEGDILAECINSAMPKGKS 1733
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 112-225 2.61e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  112 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrrqleyeARQIRAAmEEQLgtcQDMEKR 191
Cdd:COG4942    29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAL--------------------ARRIRAL-EQEL---AALEAE 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 569003037  192 AQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQ 225
Cdd:COG4942    85 LAELEKEIAELRAELEAQKEELAELLRALYRLGR 118
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 112-240 2.83e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037  112 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrRQLEYEARQIRAAMEEQLGTCQDMEKR 191
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEA--------------QAEEYELLAELARLEQDIARLEERRRE 313

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 569003037  192 AQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQSRHDAASHEAGRQHE 240
Cdd:COG1196   314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 112-240 4.95e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 42.65  E-value: 4.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037   112 LEELEKErsllLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfSLQTDMTRRQLEyEARQIRAAMEEQlgtcqdMEKR 191
Cdd:TIGR00618  224 LEKELKH----LREALQQTQQSHAYLTQKREAQEEQLKK------QQLLKQLRARIE-ELRAQEAVLEET------QERI 286

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 569003037   192 AQRR--------IARIQQIEKDILRVRQLLQSQAAEAERSSQSRHDAASHEAGRQHE 240
Cdd:TIGR00618  287 NRARkaaplaahIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQ 343
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 318-370 8.10e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.10e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 569003037    318 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 370
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1253-1270 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 569003037  1253 ETIQTYCVEDTPICFSRC 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2254-2399 8.69e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2254 PASKSPSEGPGATTSPRGTKPA----GKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISP 2329
Cdd:PHA03307  278 PSSRPGPASSSSSPRERSPSPSpsspGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPP 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003037 2330 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGL 2399
Cdd:PHA03307  358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAF 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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