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Conserved domains on  [gi|569000278|ref|XP_006524332|]
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beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 242-509 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23986:

Pssm-ID: 480271  Cd Length: 270  Bit Score: 574.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 242 TGPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVPGVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSA 321
Cdd:cd23986    3 SRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 322 PTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPF 401
Cdd:cd23986   83 PTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 402 YILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLL 481
Cdd:cd23986  163 YILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLL 242

                        250       260
                 ....*....|....*....|....*...
gi 569000278 482 YEKLLVQRLNTGTQADLHHKGKVVLPGF 509
Cdd:cd23986  243 YEKLLIQRMNKGTEDDLYRKGKVILPGF 270
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 242-509 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 574.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 242 TGPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVPGVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSA 321
Cdd:cd23986    3 SRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 322 PTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPF 401
Cdd:cd23986   83 PTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 402 YILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLL 481
Cdd:cd23986  163 YILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLL 242

                        250       260
                 ....*....|....*....|....*...
gi 569000278 482 YEKLLVQRLNTGTQADLHHKGKVVLPGF 509
Cdd:cd23986  243 YEKLLIQRMNKGTEDDLYRKGKVILPGF 270
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 280-490 5.75e-34

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 128.88  E-value: 5.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278  280 LSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN--SQILANPSHHFIDSALY 357
Cdd:pfam00777  35 VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFSHPRD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278  358 KDV--ILVAWDPAPYsanlnLW-----YKKP-DYNLFTPYIQHRRKYPTQP--FYILHPKFIWQLWDIIQENTreKIQPN 427
Cdd:pfam00777 115 PFVefVLVPFKGRDL-----LWlpaflTKGNvSRSLRVLYTLKEVKIPVDPdkVLFLHPDFLRYVANFWLRSH--GLKGR 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000278  428 PPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYhelYYDAAC--TLGAY--HPLLYEKLLVQRL 490
Cdd:pfam00777 188 RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH---YYDNVLmkKGGFYgvHDMPFEFKLLQKL 251
 
Name Accession Description Interval E-value
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 242-509 0e+00

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 574.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 242 TGPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVPGVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSA 321
Cdd:cd23986    3 SRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 322 PTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPF 401
Cdd:cd23986   83 PTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 402 YILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLL 481
Cdd:cd23986  163 YILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLL 242

                        250       260
                 ....*....|....*....|....*...
gi 569000278 482 YEKLLVQRLNTGTQADLHHKGKVVLPGF 509
Cdd:cd23986  243 YEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 243-509 2.39e-148

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 425.66  E-value: 2.39e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 243 GPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVPGVPLSQlHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP 322
Cdd:cd23985    1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLRE-EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 323 TRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPFY 402
Cdd:cd23985   80 TAGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 403 ILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLY 482
Cdd:cd23985  160 ILHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLY 239

                        250       260
                 ....*....|....*....|....*..
gi 569000278 483 EKLLVQRLNTGTQADLHHKGKVVLPGF 509
Cdd:cd23985  240 EKNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 245-509 1.55e-145

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 418.60  E-value: 1.55e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 245 ELLCEMRRRVRVRTLDGREAPFSGLGWRpLVPGVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTR 324
Cdd:cd23968    3 DLLCRLKKAAPFSTLRKTTSPFKDLLSL-RYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 325 GYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPFYIL 404
Cdd:cd23968   82 GFEKDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 405 HPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEK 484
Cdd:cd23968  162 DPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEK 241

                        250       260
                 ....*....|....*....|....*
gi 569000278 485 LLVQRLNTGTQADLHHKGKVVLPGF 509
Cdd:cd23968  242 LLVRHLNVGSDDDIFRKGRATLPGF 266
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 291-490 7.04e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 159.07  E-value: 7.04e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQIL----ANPSHHFIDSALYKDVILVAWD 366
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylRGPRCGCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 367 PAPYSANLNLWYKKPDYNLFTpYIQHRRkyptqpfyilhPKFIWQLWDIIQ-ENTREKIQPNPPSSGFIGILIMMSMCKE 445
Cdd:cd19952   81 AAAADFKRLKRRKKRHDNAVL-LLTDPA-----------PDLLSYVRKRLEkLGLKSFFGGNAPSSGLLAVLLALQLCDS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 569000278 446 VHVYEYIPSVRQTELCHYHelYYDAACTLG--AYHPLLYEKLLVQRL 490
Cdd:cd19952  149 VDLYGFGVDSGHAPKVPYH--YYDLVEAEEgtAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 280-490 5.75e-34

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 128.88  E-value: 5.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278  280 LSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN--SQILANPSHHFIDSALY 357
Cdd:pfam00777  35 VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFSHPRD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278  358 KDV--ILVAWDPAPYsanlnLW-----YKKP-DYNLFTPYIQHRRKYPTQP--FYILHPKFIWQLWDIIQENTreKIQPN 427
Cdd:pfam00777 115 PFVefVLVPFKGRDL-----LWlpaflTKGNvSRSLRVLYTLKEVKIPVDPdkVLFLHPDFLRYVANFWLRSH--GLKGR 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000278  428 PPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYhelYYDAAC--TLGAY--HPLLYEKLLVQRL 490
Cdd:pfam00777 188 RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHH---YYDNVLmkKGGFYgvHDMPFEFKLLQKL 251
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 291-473 5.30e-27

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 108.15  E-value: 5.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRiinsqiLANPSHHFIDSALYK---DVILVAWDP 367
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR------MFYPESAFRDPEEYDsdwLLVLVPFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 368 APYsanlnLW-----YKKPDYNLFTPYIQHRRKYPTQP--FYILHPKFIWQL-WDIIQENTREKIQPNPPSSGFIGILIM 439
Cdd:cd23967   79 MDL-----LWlqaviKGKKPNGKGGFWKKIATSVPKPPkkIRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGIIAIVMA 153

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 569000278 440 MSMCKEVHV--YEYIPSVRQTelcHYHelYYDAACT 473
Cdd:cd23967  154 LHYCDEVDIagFGYDPSDPNA---PLH--YYDSLTM 184
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 289-489 1.16e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 107.71  E-value: 1.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 289 SSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILANPshHFIDSALYKDVILVA 364
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVShsslPRLLRNA--ILLLAGTRAPTVVVF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 365 WDPapysanlnlwYKKPDYNLFTPYIQHRR---KYPTQPFYILHPKFIWQLWDIIQENT-REKIQPNP-PSSGFIGILIM 439
Cdd:cd23965   80 WGP----------ETKMNKDGAGKYNLLRSlskKYPDVEFYSLTPEKMDYADELFEKETgKSRIKSGTwLSTGWFTMLLA 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569000278 440 MSMCKEVHVYEYIP----SVRQTELCHYHelYYDA----ACT--------LGAYHPLLYEKLLVQR 489
Cdd:cd23965  150 LDVCDEIKVYGMVPenycREHPNSKVPYH--YYEPgglkECTyynyhenaLKGGHRFITEKAVFAR 213
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 281-469 4.71e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 107.35  E-value: 4.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 281 SQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILanpsHHFIDSALYKDV 360
Cdd:cd23963   56 SPFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSIL----KRRYNSLKKNRD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 361 ILVAWDpapYSANLN---LWYKKPDYN-----LFTPYIQHRRKYPTQPFYILHPKF---IWQLWdiiqentREKIQPNPP 429
Cdd:cd23963  132 RDKFLN---RLKEYNgsiLWYPKFSFKsstnlLLKAARALKKNGLNLTVVYSNPEHflaVQKFW-------KRRGLEKRP 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 569000278 430 SSGFIGILIMMSMCKEVHVYEYIP---SVRQTELcHYHelYYD 469
Cdd:cd23963  202 STGLYLVSLALTFCDEIHLYGFWPfptDPNGRPV-PYH--YYD 241
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 290-490 2.94e-23

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 97.43  E-value: 2.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 290 SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRII-------NSQILANPSHHFidsalykdvIL 362
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesaqfDPGIENDPDTLL---------VL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 363 VAWDPAPYSANLNLWY--KKPDYNLFTPYIQHRRKYPTQpFYILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMM 440
Cdd:cd23982   75 VPFKPLDFYWLYEILSneKRVRKGFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITLAL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569000278 441 SMCKEVHV--YEYIPSVRQTELCHyhelYYDAAcTL----GAYHPLLYEKLLVQRL 490
Cdd:cd23982  154 HLCDEVHIagFGYPDNGNSNQPIH----YYNQI-TLksmaNSGHNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 291-490 1.29e-21

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 92.89  E-value: 1.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ-ILANPSHHFIDSAlykdVILVAWDPA- 368
Cdd:cd23984    5 CVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPEsIFSDPSHYDPNTT----VVLIPFKPHd 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 369 -----------PYSAN-------LNLWYKKPDYNLFTPYIQHRRKYPTQPFYILHPKfiwqlwdiiqentreKIQPNPPS 430
Cdd:cd23984   81 lrwlldllmgkKVSAKgfwkkpaLNLIYKPNQIRILNPFILRIAAYELLHFPKRFPK---------------EKKPKHPT 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569000278 431 SGFIGILIMMSMCKEVHV--YEYIPSVRQTELcHYHELYYDAACTLGAYHPLLYEKLLVQRL 490
Cdd:cd23984  146 TGIIAITLALHICNEVHIagFKYDFSNLNSTL-HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 290-449 8.90e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 91.08  E-value: 8.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 290 SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ----ILANPSHHFIDSAlykDVILVAW 365
Cdd:cd23977    3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQQSR---DTKYVIW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 366 DPapySANLNLWYKKPDYNLFtpyIQHRRKYPTQPFYILHPKFIWQLWDIIQENT-REKIQPNP-PSSGFIGILIMMSMC 443
Cdd:cd23977   80 GP---ERNMDRDGGGKTYRAL---LTLAKMYPHLQVYTLTEEKMAYCDGVFQNETgKNRMKSGSfLSTGWFTMILALELC 153


                 ....*.
gi 569000278 444 KEVHVY 449
Cdd:cd23977  154 EEILVY 159
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 291-452 2.39e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 86.91  E-value: 2.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQ----ILANPSHHFIDSalyKDVILVAWD 366
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET---NETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 367 PApysANLNLWYKKPDYNLFTPYIQhrrKYPTQPFYILHPKFIWQLWDIIQENT-REKIQPNP-PSSGFIGILIMMSMCK 444
Cdd:cd23975   81 PF---RNMRKDGKGIVYNMLKKAVE---SYPQAKIYVTTEKRMSYCDTVFKKETgKDRVQSGSyLSTGWFTLILAMDACY 154


                 ....*...
gi 569000278 445 EVHVYEYI 452
Cdd:cd23975  155 GIHVYGMI 162
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 281-506 6.39e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 86.70  E-value: 6.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 281 SQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYK-- 358
Cdd:cd23969   57 SPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEkf 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 359 --------DVILvaWDPAPYSANLNlwykkpDYNLFTPYI--QH----RRKYPTQPFYilhpKFIWQLWdiiqenTREKI 424
Cdd:cd23969  137 verlrqlgDSIL--WIPAFVSKGGE------EHVQWTNEIilKHklnvKTAYPPLRLN----HAIRGYW------LTTKF 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 425 QPNPPSSGFIGILIMMSMCKEVHVYEYIP---SVRQTELcHYHelYYD--AACTLGAYH--PLLYEKLLVqrlntgtqad 497
Cdd:cd23969  199 RIKRPSTGLLMYTLATRFCDEIHLYGFYPfseDGNGRAV-KYH--YYDnrKYLTTARPHkmPEEFRALRS---------- 265


                 ....*....
gi 569000278 498 LHHKGKVVL 506
Cdd:cd23969  266 LHQRGALRL 274
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 289-489 6.41e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 85.68  E-value: 6.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 289 SSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILANPsHHFIDsaLYKDVILVA 364
Cdd:cd23978    2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRP-QEFLN--RTPETTLIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 365 WDPApysanlNLWYKKPDYNLFTPYIQHRRKYPTQPFYILHPKFIWQLWDIIQENT---REKIQpNPPSSGFIGILIMMS 441
Cdd:cd23978   79 WGPP------NKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETgrdRKKSH-SWLSTGWFTMVIAVE 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569000278 442 MCKEVHVYEYIP----SVRQTEL---CHYHELYYDAACTL---------GAYHPLLYEKLLVQR 489
Cdd:cd23978  152 LCDNVHVYGMVPpnycSKRPTPKkmpYHYYEPKGPDECVTyiqnehgrrGNHHRFITEKRVFAR 215
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 290-465 1.58e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 86.16  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 290 SCAVVmSAGAILNSS-LGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRI--INSQILANPSHHFIDS-ALYKDVILVAW 365
Cdd:cd23964   84 RCAVV-GNGGILNGSgKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTffPESLHNSLLKHVPQDKdTKYLFIPFKIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 366 DpAPYSANLNLWYKKPDYNLF--TPYIQHRRKYPTQPFYILHPKFIwqlwDIIQENTREKIQPNPPSSGFIGILIMMSMC 443
Cdd:cd23964  163 D-YDYLDAVLSGKPVPDGCDKgkRPPPLFGPKLNATNVRLLHPDFI----RYLFNRWLNSSTSYRPTTGALMLLTALHTC 237

                        170       180
                 ....*....|....*....|..
gi 569000278 444 KEVHVYEYIPSVRQTElcHYHE 465
Cdd:cd23964  238 DQVSVYGFGYDPRFSL--HYYD 257
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 288-469 1.62e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 79.61  E-value: 1.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 288 LSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTrGYEKDVGNKTTVRIINSQILANPSH-------HFIDS-ALYKD 359
Cdd:cd23971   64 LKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANPSILREKFHnlkkrrrPFVERmKVYGN 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 360 VILvaWDPA-PYSANlnlwyKKPDYNLFtpYIQHRRKYPTQPFYiLHPKFIWQL---WdiiqentREK-IQPNPPSSGFI 434
Cdd:cd23971  143 ALL--LLPAfSYTSN-----TEPSLRAL--YTLEDFGSPQKVLF-FNPEYLRNLsryW-------KSKgLKARRLSTGLM 205

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569000278 435 GILIMMSMCKEVHVYEYIP-SVR-QTELCHYHelYYD 469
Cdd:cd23971  206 LVSAALELCENVHLYGFWPfSTDlDGNPISHH--YYD 240
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 270-492 8.78e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 77.82  E-value: 8.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 270 GWRPLVPGV-PLSQLHPRglsSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQIL---- 344
Cdd:cd23970   52 NLRSLLPEVsPFQNKHYN---TCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILekyy 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 345 ------ANPSHHFIDSALYKDVILvaWDPA---PYSAnlnlwykKPDYNLFTPYIQHRRKYPTQ---PFYILhpKFIWQL 412
Cdd:cd23970  129 nnlltiQDRNNFFLSLKKLDGAIL--WIPAfffHTSA-------TVTRTLVDFFVEHRGQLKVQlawPGNIM--QHVNRY 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 413 WDIiqentrEKIQPNPPSSGFIGILIMMSMCKEVHVYEYIP---SVRQTELcHYHelYYDAACTLGAY-----HPLLYEK 484
Cdd:cd23970  198 WKT------KHLSPKRLSTGILMYTLASAICEEIHLYGFWPfgfDPTGTPL-PYH--YYDKKGTKFTTkwqesHQLPAEF 268


                 ....*...
gi 569000278 485 LLVQRLNT 492
Cdd:cd23970  269 VLLYKMHG 276
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 274-339 1.32e-15

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 76.94  E-value: 1.32e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000278 274 LVPGVPLSQLH-PRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRII 339
Cdd:cd23966   62 VVPGENPYRTRdPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM 128
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 290-484 3.55e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 75.29  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 290 SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIIN----SQILANpSHHFIDSAlyKDVILVAW 365
Cdd:cd23976   17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAhssiQRILRN-RNELLNVS--QGTVFIFW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 366 DPAPYsanlnlwYKKPDYNLFTPYIQ-HRRKYPTQPFYILHPKFIWQLWDIIQENTRE--KIQPNPPSSGFIGILIMMSM 442
Cdd:cd23976   94 GPSNY-------MRRDGKGLVYNNLQlMNQILPKLKVYTITRHKMLQFDELFKRETGKdrKISNTWLSTGWFTMIIALEL 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569000278 443 CKEVHVYEYIPSvrqtELC----------HYHELYYDAACTL---------GAYHPLLYEK 484
Cdd:cd23976  167 CDRINVYGMVPP----DFCrdpnhpsvpyHYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 274-451 1.28e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 74.15  E-value: 1.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 274 LVPGV--PLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTvriinsqilanpsHHF 351
Cdd:cd23980   65 VVPGNvdPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-------------HHF 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 352 IDSALYKDV------ILVawdpaPYSANLNLWYKKPdynLFTPYIQH-------RRKYPTQPFYILHPKFIWQLWD-IIQ 417
Cdd:cd23980  132 VYPESFRELaqnvsmILV-----PFKTLDLEWVISA---TTTGTISHtyvpvprKIKVKKEKILIYHPAFIKYVFDrWLQ 203

                        170       180       190
                 ....*....|....*....|....*....|....
gi 569000278 418 ENTREkiqpnpPSSGFIGILIMMSMCKEVHVYEY 451
Cdd:cd23980  204 GHGRY------PSTGILSVIFSLHVCDEVDLYGF 231
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 291-490 2.16e-14

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 72.08  E-value: 2.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRII------NSQILANPSHHFIdSALYKDVILvA 364
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapKSEQEYDPTSLFV-AVLFKSVDF-A 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 365 W-------DPAPYSANLNLWYKKPDynlftpyiqhrrKYPTQP--FYILHPKFIWQL-WDIIQENTREKI----QPNPPS 430
Cdd:cd23983   83 WlkamvkkEPLSFWSRLFFWKEVAD------------SIPLKPsqFRILNPLIIKETaLDILQYPEPQSRlwgwDKNVPT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569000278 431 SGFIGILIMMSMCKEVHVYEYIPSVRQTEL-CHYHELYYDAACTLGAYHPLLYEKLLVQRL 490
Cdd:cd23983  151 LGVTAVVLATHLCDEVSLAGFGYDLSQPHApLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 291-490 1.26e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 69.95  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYkdvILVAWDPAPY 370
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLF---VLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 371 SanlnlWYKkpdynlftpYIQHRRKY--------------PTQP--FYILHPKFiwqlwdiIQENTREKI---------- 424
Cdd:cd23981   82 K-----WLK---------YIVYKEKVsasdgfwksvatrvPREPheIRILNPYF-------IQEAAFSFIglpfnnglmg 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569000278 425 QPNPPSSGFIGILIMMSMCKEVHV--YEYIPSVRQTELcHYHELYYDAACTLGAYHPLLYEKLLVQRL 490
Cdd:cd23981  141 RGNIPTLGSVAITMALHNCDEVAVagFGYDMNTPNAPL-HYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 291-506 1.36e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 70.94  E-value: 1.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRG-YEKDVGNKTTVRIINSQILA-------NPSHHFI-DSALYKDVI 361
Cdd:cd23991   67 CAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISikyaklnERRKPFLeTVSVYGDAF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 362 LVAwdPA-PYSANLNLWYKkpdynlfTPYIQHRRKYPTQPFYiLHPKF---IWQLWdiiqentREK-IQPNPPSSGFIGI 436
Cdd:cd23991  147 LLL--PAfSYRSNTALSFK-------VYYTLEDFKAKQKVIF-FHPIYlkhLAQFW-------RSKgVQVYRLSTGLMIT 209

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569000278 437 LIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYH--PLLYEKLLvqrlntgtqaDLHHKGKVVL 506
Cdd:cd23991  210 SAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHsmPKEFYQLL----------QLHSKGILKL 271
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 274-469 3.73e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 70.17  E-value: 3.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 274 LVPGVPLSQL---HPRGLS---SCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRI-----INSQ 342
Cdd:cd23973   63 LIPKPKEQQLlalSPPGGDgciRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVhtahsITSS 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 343 ILANPSHHFIDSALYKDV--ILVAWDPAPYS--ANLNLWYKKPDYNLF--TPYIQHRRKYPTQPFYILHPKFIWQLWD-I 415
Cdd:cd23973  143 LMILQKRGFKNIPQDKDIkyILFPEGPRDYQwlEALLKNKTIPSGAYYgrRPRSYFSGDFTEDKYLVLHPDFLRYVKNrF 222

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569000278 416 IQENTREKI--QPNPPSSGFIGILIMMSMCKEVHVYEYIpsvrqTE-LCHYHELYYD 469
Cdd:cd23973  223 LRSKTLKGKywAIYRPTTGAFLLLTALHLCDTVSAYGFI-----TEdYRKYPDHYYD 274
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 291-506 5.19e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 69.78  E-value: 5.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANpshhfiDSALYKDvilVAWDPAPY 370
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMN------SLRAYAG---VGFNGPPQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 371 SAN---LNLWYKKPDYNLFTPYIQH--------RRKYP---------TQPFYILHPKFIWQ-----LWDIIQENTREKIQ 425
Cdd:cd23974  158 SKEtryIFLPDHDRDYLLVKAALTHtpidrgrdKSKRPskyfgkdvtAEKFKIYHPDFIRYlrnrfLWSPILNTKQRDIY 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 426 pnPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTelchYHELYYDAactlgAYHPLLYEKLLVQRLNTGTQADLHHKGKVV 505
Cdd:cd23974  238 --RPSTGAVMLLAALHTCDQVSAYGFMTPDYGK----YSDHYYDK-----TYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306


                 .
gi 569000278 506 L 506
Cdd:cd23974  307 L 307
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 274-470 4.81e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.50  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 274 LVPGVplSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFId 353
Cdd:cd23987   52 LLPRT--SPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLV- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 354 SALYKDVIL---------VAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTqpFYILHPkfIWQLWdiiqenTREKI 424
Cdd:cd23987  129 NETWKEKFLqrlqslngsILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPS--LRLLHA--VRGYW------LTNKV 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 569000278 425 QPNPPSSGFIGILIMMSMCKEVHVYEYIPSVR--QTELCHYHelYYDA 470
Cdd:cd23987  199 HIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRdqNQNPVKYH--YYDS 244
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 258-491 9.58e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.92  E-value: 9.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 258 TLDGREAPFsglGWRPLVPGVPLSQLH----------------PRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSA 321
Cdd:cd23972   39 RLSQRKVPY---GWKGLSHQVVASTLSllndsanaklffprdtPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 322 PTRGYEKDVGNKT-----TVRIINSQILANPSHHFIDSALYKDV--ILVAWDPAPY----SANLNL----WYKKPD--YN 384
Cdd:cd23972  116 VIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTRTPQGQDLqyIFIPSDIRDYvmlrSAILGVpvpeGLDKGDrpHK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 385 LFTPyiqhrrKYPTQPFYILHPKFIWQLWDIIQENTREKIQPNP---PSSGFIGILIMMSMCKEVHVYEYIPSVRQTELC 461
Cdd:cd23972  196 YFGP------EASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHlymPSTGALMLLTALHTCDQVSAYGFITSNYWKFSD 269

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 569000278 462 HYHE------LYYdaactlgAYHPLLYEKLLVQRLN 491
Cdd:cd23972  270 HYYErkkkplVFY-------ANHDMLLEAALWRRLH 298
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 274-506 1.11e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 62.28  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 274 LVPGVplSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQI-------LAN 346
Cdd:cd23988   52 LLPEV--SPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVvqrafggFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 347 PS--HHFIDS-ALYKDVILvaWDPA-------PYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPFYILHpkfiwqlwdii 416
Cdd:cd23988  130 ESdrEKFVHRlSMLNDSVL--WIPAfmvkggeKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTN----------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 417 qentreKIQPNPPSSGFIGILIMMSMCKEVHVYEYIP-----SVRQTELCHYHELYYDAACTLGAYH-PLLYEKLLVqrl 490
Cdd:cd23988  197 ------KVNIKRPSTGLLMYTLATRFCDEIHLYGFWPfpkdaNGNPVKYHYYDDLKYRYFSNAGPHRmPLEFKTLNV--- 267

                        250
                 ....*....|....*.
gi 569000278 491 ntgtqadLHHKGKVVL 506
Cdd:cd23988  268 -------LHNRGALKL 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 274-451 2.15e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 61.43  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 274 LVPGV-PLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTvriinsqilanpsHHFI 352
Cdd:cd23979   65 IIPGEnPYRSWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT-------------HHFM 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 353 DSALYKDVIL-VAWDPAPYSANLNLWYKKPdynLFTPYIqhRRKY-PTQPFY--------ILHPKFIWQLWDIIQENtre 422
Cdd:cd23979  132 YPESAKNLPAnVSFVLVPFKTLDLLWITSA---LSTGQI--RFTYaPVKQFLrvdkdkvqIYNPAFFKYIHDRWTEH--- 203

                        170       180
                 ....*....|....*....|....*....
gi 569000278 423 kiQPNPPSSGFIGILIMMSMCKEVHVYEY 451
Cdd:cd23979  204 --HGRYPSTGMLVLFFALHVCDEVNVYGF 230
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 291-483 3.92e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 57.54  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 291 CAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTTVRIINSQILANPSHH-------FIDS-ALYKDVI 361
Cdd:cd23990   67 CAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKlekwrrpFYEVlQVYENAS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000278 362 LVAwdPAPYSAnlnlwyKKPDYNLFTPYIQHRRKYPtQPFYILHPKFiwqLWDIIQENTREKIQPNPPSSGFIGILIMMS 441
Cdd:cd23990  147 VVL--PAFYNT------RNTDVSIRVKYVLDDFESQ-QAVYYFHPQY---LLNVSRFWLRQGVRAKRISSGLMLVTAALE 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 569000278 442 MCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYE 483
Cdd:cd23990  215 LCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPRPGFHAMPSE 256
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 285-348 3.06e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 51.76  E-value: 3.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569000278 285 PRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAP-TRGYEKDVGNKTTVriinsqILANPS 348
Cdd:cd23989   60 QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL------VTANPS 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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