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Conserved domains on  [gi|568997422|ref|XP_006523040|]
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nucleolar pre-ribosomal-associated protein 1 isoform X1 [Mus musculus]

Protein Classification

NPA1/URB1 family protein( domain architecture ID 11190036)

NPA1/URB1 family protein similar to human nucleolar pre-ribosomal-associated protein 1, also called URB1 ribosome biogenesis 1 homolog that is essential for ribosome biogenesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Npa1 pfam11707
Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in ...
78-396 2.16e-79

Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.


:

Pssm-ID: 463325  Cd Length: 332  Bit Score: 266.02  E-value: 2.16e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422    78 CAEIFQLLSGEKRPESE-MLLIFQAFEAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTA 156
Cdd:pfam11707    1 LSEIFQAWSYAAQVNNEsLLSAVTAVLALLLRTLSSHLDFRPYGLGLIKTILQNHLKLLYRGLSSSKPSLISPTLRLLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   157 MVT-QGPEAARDVCSSLDLNKKALFALVT---------KRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVLEIKEFIPC 226
Cdd:pfam11707   81 IVSfDGGALAREVLSAFDFTLKSLPRLLTprkredeegTEDPKGKPSIRTNFIRFLLSFLSSGPPLLKKDLLEQKKILSA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   227 IFSsGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAALYNWNGITDVTPEkpesaaisaeeagkaMV 306
Cdd:pfam11707  161 LFK-GLKQDPPELVLEILETLKTHVLKDKSIKRTTKSKLFNESVLSKLASLYSRDDEEDSEDE---------------SV 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   307 RDLVHNFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAG------------------DDLVASLVVSILK 368
Cdd:pfam11707  225 ADLVHEFLLALCTDPGHGVCFPDSGWYPRSADPSSSGSGVPVWVNKKSFkiynkllsnllktlkpweDERQQELVLKILK 304
                          330       340
                   ....*....|....*....|....*...
gi 568997422   369 VCPDLLTKYFKEVTFSFLPRVKSTWLNN 396
Cdd:pfam11707  305 ACPELVAPYFNKLSFSFDPRLTSTWIGN 332
NopRA1 pfam16201
Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and ...
1610-1799 1.60e-64

Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and plant nucleolar proteins that also carry Npa1, pfam11707.


:

Pssm-ID: 465063  Cd Length: 197  Bit Score: 217.79  E-value: 1.60e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1610 LGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRT-------PNLRLPFTVALFIAKAAVQ 1682
Cdd:pfam16201    1 LGLLIAALSSEDPEIRKAAYTVLSKFLASLEESRFKEKRQLLLLLSELLNTLITlgneepePNPRLPSLIALFLARALRI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1683 ILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNS 1762
Cdd:pfam16201   81 LLNPSHFLYPKINRFLLSRPSLDLNDIPLFYSLLYSSSEEYYKERSWLLELLLDGLRTEDDLELLRRRGVFELLLSLYNS 160
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 568997422  1763 PLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTW 1799
Cdd:pfam16201  161 PYLDRKLRSLILEILYRATRIPGGATTLITRYGLLSW 197
 
Name Accession Description Interval E-value
Npa1 pfam11707
Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in ...
78-396 2.16e-79

Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.


Pssm-ID: 463325  Cd Length: 332  Bit Score: 266.02  E-value: 2.16e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422    78 CAEIFQLLSGEKRPESE-MLLIFQAFEAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTA 156
Cdd:pfam11707    1 LSEIFQAWSYAAQVNNEsLLSAVTAVLALLLRTLSSHLDFRPYGLGLIKTILQNHLKLLYRGLSSSKPSLISPTLRLLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   157 MVT-QGPEAARDVCSSLDLNKKALFALVT---------KRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVLEIKEFIPC 226
Cdd:pfam11707   81 IVSfDGGALAREVLSAFDFTLKSLPRLLTprkredeegTEDPKGKPSIRTNFIRFLLSFLSSGPPLLKKDLLEQKKILSA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   227 IFSsGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAALYNWNGITDVTPEkpesaaisaeeagkaMV 306
Cdd:pfam11707  161 LFK-GLKQDPPELVLEILETLKTHVLKDKSIKRTTKSKLFNESVLSKLASLYSRDDEEDSEDE---------------SV 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   307 RDLVHNFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAG------------------DDLVASLVVSILK 368
Cdd:pfam11707  225 ADLVHEFLLALCTDPGHGVCFPDSGWYPRSADPSSSGSGVPVWVNKKSFkiynkllsnllktlkpweDERQQELVLKILK 304
                          330       340
                   ....*....|....*....|....*...
gi 568997422   369 VCPDLLTKYFKEVTFSFLPRVKSTWLNN 396
Cdd:pfam11707  305 ACPELVAPYFNKLSFSFDPRLTSTWIGN 332
NopRA1 pfam16201
Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and ...
1610-1799 1.60e-64

Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and plant nucleolar proteins that also carry Npa1, pfam11707.


Pssm-ID: 465063  Cd Length: 197  Bit Score: 217.79  E-value: 1.60e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1610 LGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRT-------PNLRLPFTVALFIAKAAVQ 1682
Cdd:pfam16201    1 LGLLIAALSSEDPEIRKAAYTVLSKFLASLEESRFKEKRQLLLLLSELLNTLITlgneepePNPRLPSLIALFLARALRI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1683 ILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNS 1762
Cdd:pfam16201   81 LLNPSHFLYPKINRFLLSRPSLDLNDIPLFYSLLYSSSEEYYKERSWLLELLLDGLRTEDDLELLRRRGVFELLLSLYNS 160
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 568997422  1763 PLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTW 1799
Cdd:pfam16201  161 PYLDRKLRSLILEILYRATRIPGGATTLITRYGLLSW 197
 
Name Accession Description Interval E-value
Npa1 pfam11707
Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in ...
78-396 2.16e-79

Ribosome 60S biogenesis N-terminal; Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.


Pssm-ID: 463325  Cd Length: 332  Bit Score: 266.02  E-value: 2.16e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422    78 CAEIFQLLSGEKRPESE-MLLIFQAFEAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTA 156
Cdd:pfam11707    1 LSEIFQAWSYAAQVNNEsLLSAVTAVLALLLRTLSSHLDFRPYGLGLIKTILQNHLKLLYRGLSSSKPSLISPTLRLLTE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   157 MVT-QGPEAARDVCSSLDLNKKALFALVT---------KRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVLEIKEFIPC 226
Cdd:pfam11707   81 IVSfDGGALAREVLSAFDFTLKSLPRLLTprkredeegTEDPKGKPSIRTNFIRFLLSFLSSGPPLLKKDLLEQKKILSA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   227 IFSsGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAALYNWNGITDVTPEkpesaaisaeeagkaMV 306
Cdd:pfam11707  161 LFK-GLKQDPPELVLEILETLKTHVLKDKSIKRTTKSKLFNESVLSKLASLYSRDDEEDSEDE---------------SV 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422   307 RDLVHNFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAG------------------DDLVASLVVSILK 368
Cdd:pfam11707  225 ADLVHEFLLALCTDPGHGVCFPDSGWYPRSADPSSSGSGVPVWVNKKSFkiynkllsnllktlkpweDERQQELVLKILK 304
                          330       340
                   ....*....|....*....|....*...
gi 568997422   369 VCPDLLTKYFKEVTFSFLPRVKSTWLNN 396
Cdd:pfam11707  305 ACPELVAPYFNKLSFSFDPRLTSTWIGN 332
NopRA1 pfam16201
Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and ...
1610-1799 1.60e-64

Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and plant nucleolar proteins that also carry Npa1, pfam11707.


Pssm-ID: 465063  Cd Length: 197  Bit Score: 217.79  E-value: 1.60e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1610 LGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRT-------PNLRLPFTVALFIAKAAVQ 1682
Cdd:pfam16201    1 LGLLIAALSSEDPEIRKAAYTVLSKFLASLEESRFKEKRQLLLLLSELLNTLITlgneepePNPRLPSLIALFLARALRI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568997422  1683 ILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNS 1762
Cdd:pfam16201   81 LLNPSHFLYPKINRFLLSRPSLDLNDIPLFYSLLYSSSEEYYKERSWLLELLLDGLRTEDDLELLRRRGVFELLLSLYNS 160
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 568997422  1763 PLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTW 1799
Cdd:pfam16201  161 PYLDRKLRSLILEILYRATRIPGGATTLITRYGLLSW 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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