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Conserved domains on  [gi|568996556|ref|XP_006522779|]
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protein HEG homolog 1 isoform X2 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 10043351)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
957-988 1.39e-10

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.39e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996556    957 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 988
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 550-917 5.06e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  550 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 629
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  630 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 709
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  710 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 787
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  788 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 867
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996556  868 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 917
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-954 1.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996556  918 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 954
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
957-988 1.39e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.39e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996556    957 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 988
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-917 5.06e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  550 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 629
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  630 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 709
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  710 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 787
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  788 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 867
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996556  868 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 917
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 957-989 1.27e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.57  E-value: 1.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568996556  957 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 989
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
957-986 1.44e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.44e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568996556   957 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 986
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-954 1.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996556  918 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 954
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 556-892 5.88e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 5.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   556 KQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVnmPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQPFSSALPSTRSP 635
Cdd:pfam17823   89 EHTPHGTDLSEPATREGAADGAASRALAAAASSS--PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   636 GSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQ 715
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVG 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   716 QEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPA-------LTGFSTGPALPATSTSLAQMS---PALTSAMPQTTH 785
Cdd:pfam17823  247 TVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAkhmpsdtMARNPAAPMGAQAQGPIIQVStdqPVHNTAGEPTPS 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   786 SPVTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAIttegnrEHTDPTTQPIPLTTSTTSAGE---RT 862
Cdd:pfam17823  327 PSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV------EATSPTTQPSPLLPTQGAAGPgilLA 400

                          330       340       350
                   ....*....|....*....|....*....|
gi 568996556   863 TELGRAEESSPSHFLTPSSPQTTDVSTAEM 892
Cdd:pfam17823  401 PEQVATEATAGTASAGPTPRSSGDPKTLAM 430
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 921-953 8.54e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 8.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568996556   921 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 953
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
918-954 1.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.31e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568996556    918 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 954
Cdd:smart00179    2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
957-988 1.39e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 57.26  E-value: 1.39e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996556    957 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 988
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-917 5.06e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 5.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  550 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 629
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  630 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPRVTSvqmstaisaiALIPSNQTANPk 709
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARP----------TVGSLTSLADP- 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  710 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 787
Cdd:PHA03247 2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  788 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 867
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 568996556  868 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 917
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 957-989 1.27e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 54.57  E-value: 1.27e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568996556  957 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 989
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
957-986 1.44e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.44e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568996556   957 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 986
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-954 1.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.58e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568996556  918 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 954
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 960-991 1.83e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.55  E-value: 1.83e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568996556  960 EC-LSSPCPPLATCNNTQGSFTCRCPVGYQLEK 991
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 556-892 5.88e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 5.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   556 KQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVnmPNTLVLDTGTKPVEDPSDSRVPSTQPSPSQPQPFSSALPSTRSP 635
Cdd:pfam17823   89 EHTPHGTDLSEPATREGAADGAASRALAAAASSS--PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAAS 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   636 GSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQSTPQ 715
Cdd:pfam17823  167 APHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVG 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   716 QEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPA-------LTGFSTGPALPATSTSLAQMS---PALTSAMPQTTH 785
Cdd:pfam17823  247 TVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAkhmpsdtMARNPAAPMGAQAQGPIIQVStdqPVHNTAGEPTPS 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   786 SPVTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAIttegnrEHTDPTTQPIPLTTSTTSAGE---RT 862
Cdd:pfam17823  327 PSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV------EATSPTTQPSPLLPTQGAAGPgilLA 400

                          330       340       350
                   ....*....|....*....|....*....|
gi 568996556   863 TELGRAEESSPSHFLTPSSPQTTDVSTAEM 892
Cdd:pfam17823  401 PEQVATEATAGTASAGPTPRSSGDPKTLAM 430
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 921-953 8.54e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 8.54e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568996556   921 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 953
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 563-895 9.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  563 DDDEPAQSSTESP--VLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSALP------STRS 634
Cdd:PHA03247 2652 PRDDPAPGRVSRPrrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPlppgpaAARQ 2730

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  635 PGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTF--PHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQS 712
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  713 TPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPAL--TSAMPQTTHSPVTS 790
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPA 2890

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  791 PSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGnREHTDPTTQPIPLTTSTTSAGERTTELG---- 866
Cdd:PHA03247 2891 VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-RPQPPLAPTTDPAGAGEPSGAVPQPWLGalvp 2969

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 568996556  867 --------RAEESSPSHFLTPSSPQTTDVSTAEMLTS 895
Cdd:PHA03247 2970 grvavprfRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 965-988 1.16e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 1.16e-05
                           10        20
                   ....*....|....*....|....
gi 568996556   965 PCPPLATCNNTQGSFTCRCPVGYQ 988
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYT 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 661-911 1.75e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 1.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   661 YSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTA-ISAIALIPSNQTANPKNQStPQQEKPITEAKSPSLVSPptdsTKAV 739
Cdd:pfam05109  439 FAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSP----TSAV 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   740 TVSLPPGAPWSPALTG---FSTGPALPATSTSLA---------QMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAVVV 807
Cdd:pfam05109  514 TTPTPNATSPTPAVTTptpNATSPTLGKTSPTSAvttptpnatSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSP 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   808 HTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERttelgraeessPSHFLTPSSPQTTDV 887
Cdd:pfam05109  594 TVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLR-----------PSSISETLSPSTSDN 662

                          250       260
                   ....*....|....*....|....*.
gi 568996556   888 STAEM--LTSRYITFAAQSTSQSPTA 911
Cdd:pfam05109  663 STSHMplLTSAHPTGGENITQVTPAS 688
EGF_CA smart00179
Calcium-binding EGF-like domain;
918-954 1.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.31e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568996556    918 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 954
Cdd:smart00179    2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
EGF smart00181
Epidermal growth factor-like domain;
960-991 1.50e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 1.50e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568996556    960 ECLS-SPCPPlATCNNTQGSFTCRCPVGYQLEK 991
Cdd:smart00181    1 ECASgGPCSN-GTCINTPGSYTCSCPPGYTGDK 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 924-954 4.39e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 4.39e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568996556  924 NPCLHDGKCIVdlTGRGYRCVCPPAWQGE-NC 954
Cdd:cd00053     6 NPCSNGGTCVN--TPGSYRCVCPPGYTGDrSC 35
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 921-994 4.39e-04

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 39.33  E-value: 4.39e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568996556   921 CTVNPCLHDGKCIvdltgrgyrcvcPPAWQGENCSVDVNeclsspCPPLATCNNTqgsfTCRCPVGYQLEKGIC 994
Cdd:pfam01683    1 CPPGQVLVNGQCV------------PKVAPGESCEADEQ------CPGGSVCVNG----VCQCPPGFTPVNGRC 52
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 961-987 5.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 5.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 568996556   961 CLSSPCPPLATCNNTQGSFTCRCPVGY 987
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGY 27
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 610-855 2.02e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.22  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  610 SRVPSTQPSPSQPQPFS--SALPSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTS 687
Cdd:PLN03209  321 AKIPSQRVPPKESDAADgpKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSPIPTPPSSSPASSKS 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  688 VQMSTAISAIALIPSNQTANPKNQSTP-----QQEKPIT------EAKSPSLVSPPTDSTKAVTVSLPPGAPWSPaltgf 756
Cdd:PLN03209  401 VDAVAKPAEPDVVPSPGSASNVPEVEPaqveaKKTRPLSpyaryeDLKPPTSPSPTAPTGVSPSVSSTSSVPAVP----- 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  757 STGPALPATSTSL---AQMSPaLTSAMPQTTHSPVTSPSTLShvealtsgavvvhTTPKKPHLPTNPEILVPHISTEGAI 833
Cdd:PLN03209  476 DTAPATAATDAAApppANMRP-LSPYAVYDDLKPPTSPSPAA-------------PVGKVAPSSTNEVVKVGNSAPPTAL 541

                         250       260
                  ....*....|....*....|..
gi 568996556  834 TTEGNreHTDPttQPIPLTTST 855
Cdd:PLN03209  542 ADEQH--HAQP--KPRPLSPYT 559
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 549-913 5.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   549 SPSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSrvpSTQPSPSQPQPFSSA 628
Cdd:pfam05109  460 APASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT---SPTPAVTTPTPNATS 536

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   629 LPSTRSPGSTSetttsspspspisllVSTLAPYSVSQT---TFPHPSSTlvphrpreprVTSVQMSTAISAIALIPSNQT 705
Cdd:pfam05109  537 PTLGKTSPTSA---------------VTTPTPNATSPTpavTTPTPNAT----------IPTLGKTSPTSAVTTPTPNAT 591

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   706 ANPKNQSTPQQEKPI----TEAKSPSLVSPPTDSTKAVT-------------VSLPPGA---PWSPALTGFSTG------ 759
Cdd:pfam05109  592 SPTVGETSPQANTTNhtlgGTSSTPVVTSPPKNATSAVTtgqhnitssstssMSLRPSSiseTLSPSTSDNSTShmpllt 671

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   760 PALPATSTSLAQMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAV--------VVHTTPKK----PHLPTNPEILVPHI 827
Cdd:pfam05109  672 SAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTstkpgevnVTKGTPPKnatsPQAPSGQKTAVPTV 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556   828 -STEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGRAEESSpshFLTPSSpqTTDVSTAEMLTSRYITFAAQSTS 906
Cdd:pfam05109  752 tSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATT---YLPPST--SSKLRPRWTFTSPPVTTAQATVP 826


                   ....*..
gi 568996556   907 QSPTALP 913
Cdd:pfam05109  827 VPPTSQP 833
PHA03247 PHA03247
large tegument protein UL36; Provisional
 406-912 6.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  406 APLREHSPPEDGAMLSDSSDLADSTSGARTPH------TSAMSTRSGERTLRSLDLSSAATRPARPTPRGNVTEHAGLLS 479
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEpaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  480 GAPTLGVTGLSYTREHGSDAGqrtssdhtdhgyvpstftkgertllsitdntsyseasesstssvkisdsPSQAQPKQSS 559
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAG-------------------------------------------------PPRRLTRPAV 2788

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  560 MSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTlvldtgTKPVEDPSDSRVPSTQPSPSQPQPFSSAL-----PSTRS 634
Cdd:PHA03247 2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS------PAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvaPGGDV 2862

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  635 PGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPrvtsvqmstaisaiALIPSNQTANPKNQSTP 714
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP--------------QAPPPPQPQPQPPPPPQ 2928

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  715 QQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALtgfsTGPALPATSTSLAQMSPaltsamPQTTHSPVTSPSTL 794
Cdd:PHA03247 2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL----VPGRVAVPRFRVPQPAP------SREAPASSTPPLTG 2998

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568996556  795 SHVEALTSGA--VVVHTTPKKP--------HLPTNPE--------ILVPHISTEGAITTEGNREHTDPTTQPIPlttSTT 856
Cdd:PHA03247 2999 HSLSRVSSWAssLALHEETDPPpvslkqtlWPPDDTEdsdadslfDSDSERSDLEALDPLPPEPHDPFAHEPDP---ATP 3075

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568996556  857 SAGERttelgraeESSPSHFLTPSspqttdVSTAEMLTSRYItfaaQSTSQSPTAL 912
Cdd:PHA03247 3076 EAGAR--------ESPSSQFGPPP------LSANAALSRRYV----RSTGRSALAV 3113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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