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Conserved domains on  [gi|568995656|ref|XP_006522348|]
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target of Nesh-SH3 isoform X34 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 648-739 1.17e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 648 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 725
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995656 726 LGEGPASNTVAFST 739
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 317-650 7.48e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  317 PEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAkEPVPKEPlHTTSKPKMPPSPEVADTTSAPLETRGIPLI--PVISPR 394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPA-PPSPLPP-DTHAPDPPPPSPSPAANEPDPHPPPTVPPPerPRDDPA 2657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  395 PSQEELQTAMEETDQSTQELFTTKIPRtTELAKTTQAPhrlHTAPVRPRIPGRPhgrPALNKTTTRPDKTKPRGTSHKNG 474
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAQASSPPQRPR-RRAARPTVGS---LTSLADPPPPPPT---PEPAPHALVSATPLPPGPAAARQ 2730

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  475 VGTGTKQAPKPPSPGRNASVDSHATR--KPGSVSGTRRPPIPhrhsSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTS 552
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARpaRPPTTAGPPAPAPP----AAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  553 PPLKAT-LHPIGTATARPGAEQKEPTAPASeeefgTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVR- 630
Cdd:PHA03247 2807 PPAAVLaPAAALPPAASPAGPLPPPTSAQP-----TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARp 2881

                         330       340
                  ....*....|....*....|....*.
gi 568995656  631 ------RFPTEEATEGNATSPPQNPP 650
Cdd:PHA03247 2882 pvrrlaRPAVSRSTESFALPPDQPER 2907
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.64e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995656 192 FGVK 195
Cdd:cd00063   72 FRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 648-739 1.17e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 648 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 725
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995656 726 LGEGPASNTVAFST 739
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 649-729 6.21e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 6.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656   649 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 726
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 568995656   727 GEG 729
Cdd:smart00060  81 GEG 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 317-650 7.48e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  317 PEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAkEPVPKEPlHTTSKPKMPPSPEVADTTSAPLETRGIPLI--PVISPR 394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPA-PPSPLPP-DTHAPDPPPPSPSPAANEPDPHPPPTVPPPerPRDDPA 2657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  395 PSQEELQTAMEETDQSTQELFTTKIPRtTELAKTTQAPhrlHTAPVRPRIPGRPhgrPALNKTTTRPDKTKPRGTSHKNG 474
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAQASSPPQRPR-RRAARPTVGS---LTSLADPPPPPPT---PEPAPHALVSATPLPPGPAAARQ 2730

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  475 VGTGTKQAPKPPSPGRNASVDSHATR--KPGSVSGTRRPPIPhrhsSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTS 552
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARpaRPPTTAGPPAPAPP----AAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  553 PPLKAT-LHPIGTATARPGAEQKEPTAPASeeefgTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVR- 630
Cdd:PHA03247 2807 PPAAVLaPAAALPPAASPAGPLPPPTSAQP-----TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARp 2881

                         330       340
                  ....*....|....*....|....*.
gi 568995656  631 ------RFPTEEATEGNATSPPQNPP 650
Cdd:PHA03247 2882 pvrrlaRPAVSRSTESFALPPDQPER 2907
fn3 pfam00041
Fibronectin type III domain;
649-732 1.14e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  649 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 725
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 568995656  726 LGEGPAS 732
Cdd:pfam00041  79 GGEGPPS 85
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 303-644 3.94e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.69  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  303 AKNETLALPAESKTPE--VEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPpSPEVADTTSAPL 380
Cdd:pfam05109 441 APNTTTGLPSSTHVPTnlTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMT-SPTSAVTTPTPN 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  381 ETRGIPLIPVISPRPSQEELQTAmeetdqSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGRPALNKTTT 459
Cdd:pfam05109 520 ATSPTPAVTTPTPNATSPTLGKT------SPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTTPTPNATSP 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  460 RPDKTKPRGTSHKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPE 526
Cdd:pfam05109 594 TVGETSPQANTTNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTS 672

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  527 RRPLPPNNVTgkpgragivsssRVTspPLKATLHPIGTAT--ARPGAeqkepTAPASEEEFGTTtdfSSSPTKETDPLGK 604
Cdd:pfam05109 673 AHPTGGENIT------------QVT--PASTSTHHVSTSSpaPRPGT-----TSQASGPGNSST---STKPGEVNVTKGT 730

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 568995656  605 PrfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATS 644
Cdd:pfam05109 731 P----------PKNATSPQAPSGQKTAVPTVTSTGGKANS 760
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
533-744 4.31e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 533 NNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPrfiGPHV 612
Cdd:COG3401  129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP---GTTY 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 613 RYIPKpenkpcSITDSVRRFPTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSG 692
Cdd:COG3401  206 YYRVA------ATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DG 274

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568995656 693 KNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 744
Cdd:COG3401  275 PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
633-784 5.57e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 633 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 710
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 711 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVS----------EPISAGRDAIWTERPFNSDSYSECKGKQYVKR 779
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESltasvdavplTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467


                 ....*
gi 568995656 780 TWYKK 784
Cdd:COG3401  468 VPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.64e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995656 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.17e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 568995656  193 GVK 195
Cdd:pfam00041  72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 568995656   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 648-739 1.17e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 648 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 725
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995656 726 LGEGPASNTVAFST 739
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 649-729 6.21e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 6.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656   649 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 726
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 568995656   727 GEG 729
Cdd:smart00060  81 GEG 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 317-650 7.48e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  317 PEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAkEPVPKEPlHTTSKPKMPPSPEVADTTSAPLETRGIPLI--PVISPR 394
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPA-PPSPLPP-DTHAPDPPPPSPSPAANEPDPHPPPTVPPPerPRDDPA 2657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  395 PSQEELQTAMEETDQSTQELFTTKIPRtTELAKTTQAPhrlHTAPVRPRIPGRPhgrPALNKTTTRPDKTKPRGTSHKNG 474
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAQASSPPQRPR-RRAARPTVGS---LTSLADPPPPPPT---PEPAPHALVSATPLPPGPAAARQ 2730

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  475 VGTGTKQAPKPPSPGRNASVDSHATR--KPGSVSGTRRPPIPhrhsSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTS 552
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARpaRPPTTAGPPAPAPP----AAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  553 PPLKAT-LHPIGTATARPGAEQKEPTAPASeeefgTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVR- 630
Cdd:PHA03247 2807 PPAAVLaPAAALPPAASPAGPLPPPTSAQP-----TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARp 2881

                         330       340
                  ....*....|....*....|....*.
gi 568995656  631 ------RFPTEEATEGNATSPPQNPP 650
Cdd:PHA03247 2882 pvrrlaRPAVSRSTESFALPPDQPER 2907
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-658 7.15e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 7.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  337 PPKLKTPHSRMPAKEPVPKEPlhttSKPKMPPSPEVADTTSAPLETRGIPLIP-VISPRPSQEELqtAMEETDQSTQELF 415
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSRLAPAILPDEPVGEPVHPrMLTWIRGLEEL--ASDDAGDPPPPLP 2556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  416 TTKIPRTTELAKTTQAPhrlhtAPvrpripgRPHGrPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVD 495
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRP-----AP-------RPSE-PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPD 2620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  496 SHATRKPGSVSGTR--RPPIPHRHSSTRPVSPERRPLPP----NNVTGKPGRAGIVSSS--RVTSPPLKATLHPIgTATA 567
Cdd:PHA03247 2621 THAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGrvsrPRRARRLGRAAQASSPpqRPRRRAARPTVGSL-TSLA 2699

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  568 RPGAEQKEP------TAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSitdsvrrfPTEEATEGN 641
Cdd:PHA03247 2700 DPPPPPPTPepaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT--------TAGPPAPAP 2771

                         330
                  ....*....|....*..
gi 568995656  642 ATSPPQNPPTNLTVVTV 658
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAV 2788
fn3 pfam00041
Fibronectin type III domain;
649-732 1.14e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  649 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 725
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 568995656  726 LGEGPAS 732
Cdd:pfam00041  79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-670 4.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  337 PPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVISPRPSqeelQTAMEETDQSTQELFT 416
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP----TTAGPPAPAPPAAPAA 2777

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  417 TKIPRTTELAKTTQAPHRlHTAPVrPRIPGrPHGRPALNKTTTRPDKTKPRGTSHKNgvGTGTKQAPKPPSPGRNASVDS 496
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESR-ESLPS-PWDPA-DPPAAVLAPAAALPPAASPAGPLPPP--TSAQPTAPPPPPGPPPPSLPL 2852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  497 HATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEP 576
Cdd:PHA03247 2853 GGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP 2926

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  577 TAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVV 656
Cdd:PHA03247 2927 PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002

                         330
                  ....*....|....
gi 568995656  657 TVEGCPSFVILDWE 670
Cdd:PHA03247 3003 RVSSWASSLALHEE 3016
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 312-650 4.57e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 4.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  312 AESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIPVI 391
Cdd:PHA03307   86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  392 SPRPSQEELQTAMeetdqsTQELFTTKIPRTTELAKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGT 469
Cdd:PHA03307  166 AASSRQAALPLSS------PEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  470 SHKNGVGTG---TKQAPKP-------PSPGRNASVDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGK 538
Cdd:PHA03307  240 SSSESSGCGwgpENECPLPrpapitlPTRIWEASGWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSS 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  539 PGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQ--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIP 616
Cdd:PHA03307  320 SSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAV 394

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 568995656  617 KPENKP---CSITDSVRRFPTEEATEGNATSPPQNPP 650
Cdd:PHA03307  395 AGRARRrdaTGRFPAGRPRPSPLDAGAASGAFYARYP 431
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 291-651 6.00e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.64  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  291 MLEISDALKAQLAKNETLAlpAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSP 370
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAA--ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  371 EVADTTSAPLETRGIPLIPVISPRPSQEELQTAMEETDQSTQELFTTKIPRttELAKTTQAPHRLHTAPVRPripgrPHG 450
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSR--QAALPLSSPEETARAPSSP-----PAE 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  451 RPalnkttTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVS--------GTRRPPIPHRHSSTRP 522
Cdd:PHA03307  193 PP------PSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSessgcgwgPENECPLPRPAPITLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  523 vSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPlkatlhpigTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPl 602
Cdd:PHA03307  267 -TRIWEASGWNGPSSRPGPASSSSSPRERSPS---------PSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES- 335

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 568995656  603 gkPRfiGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPT 651
Cdd:PHA03307  336 --SR--GAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380
PHA03247 PHA03247
large tegument protein UL36; Provisional
 311-594 1.76e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  311 PAESKTPEveklagQPVTAPRQTTSMPPKLKTPHSRMPAK--EPVPKEPLHTTSKPKMPPSPEVADTTSAPLET------ 382
Cdd:PHA03247 2702 PPPPPTPE------PAPHALVSATPLPPGPAAARQASPALpaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPappaap 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  383 -----RGIPLIPVISPRPSQEELQTAMEETDQS------TQELFTTKIPRTTELAKTTQAPhrlhTAPVRPRIPGRPH-- 449
Cdd:PHA03247 2776 aagppRRLTRPAVASLSESRESLPSPWDPADPPaavlapAAALPPAASPAGPLPPPTSAQP----TAPPPPPGPPPPSlp 2851

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  450 -------GRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRHSSTRP 522
Cdd:PHA03247 2852 lggsvapGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995656  523 vSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSS 594
Cdd:PHA03247 2932 -PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 303-644 3.94e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.69  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  303 AKNETLALPAESKTPE--VEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPpSPEVADTTSAPL 380
Cdd:pfam05109 441 APNTTTGLPSSTHVPTnlTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMT-SPTSAVTTPTPN 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  381 ETRGIPLIPVISPRPSQEELQTAmeetdqSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGRPALNKTTT 459
Cdd:pfam05109 520 ATSPTPAVTTPTPNATSPTLGKT------SPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTTPTPNATSP 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  460 RPDKTKPRGTSHKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPE 526
Cdd:pfam05109 594 TVGETSPQANTTNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTS 672

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  527 RRPLPPNNVTgkpgragivsssRVTspPLKATLHPIGTAT--ARPGAeqkepTAPASEEEFGTTtdfSSSPTKETDPLGK 604
Cdd:pfam05109 673 AHPTGGENIT------------QVT--PASTSTHHVSTSSpaPRPGT-----TSQASGPGNSST---STKPGEVNVTKGT 730

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 568995656  605 PrfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATS 644
Cdd:pfam05109 731 P----------PKNATSPQAPSGQKTAVPTVTSTGGKANS 760
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
533-744 4.31e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 533 NNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPrfiGPHV 612
Cdd:COG3401  129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP---GTTY 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 613 RYIPKpenkpcSITDSVRRFPTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSG 692
Cdd:COG3401  206 YYRVA------ATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DG 274

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568995656 693 KNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 744
Cdd:COG3401  275 PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
633-784 5.57e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 633 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 710
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 711 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVS----------EPISAGRDAIWTERPFNSDSYSECKGKQYVKR 779
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESltasvdavplTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467


                 ....*
gi 568995656 780 TWYKK 784
Cdd:COG3401  468 VPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 1.64e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995656 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.17e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 568995656  193 GVK 195
Cdd:pfam00041  72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 568995656   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 311-539 1.26e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 311 PAESKTPEVEKLAGQPVTAPR----QTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEvadtTSAPLETRGIP 386
Cdd:PTZ00449 591 PEEPKKPKRPRSAQRPTRPKSpklpELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK----SPKPPKSPKPP 666

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 387 LIPVISPRPSQEELQTA--MEET------DQSTQELFTTKIPRTTELAKTTQAPhrlhTAPVRPRIPGRPHGRPAlnktt 458
Cdd:PTZ00449 667 FDPKFKEKFYDDYLDAAakSKETkttvvlDESFESILKETLPETPGTPFTTPRP----LPPKLPRDEEFPFEPIG----- 737

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 459 tRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRhsstRPVSP-ERRPLPPNNVTG 537
Cdd:PTZ00449 738 -DPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMK----RPDSPsEHEDKPPGDHPS 812


                 ..
gi 568995656 538 KP 539
Cdd:PTZ00449 813 LP 814
PHA03247 PHA03247
large tegument protein UL36; Provisional
 309-595 2.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  309 ALPAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPleTRGIPLI 388
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPP--SRSPAAK 2874

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  389 PVISPRPSQEEL-QTAMEETDQS-TQELFTTKIPRTTELAKTTQAPHRLHTAPV---RPRIPGRPHGRPALNKTTTRPDK 463
Cdd:PHA03247 2875 PAAPARPPVRRLaRPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQpqpPPPPPPRPQPPLAPTTDPAGAGE 2954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  464 TKPRGTSHKNG-VGTGTKQAPK----PPSPGRNASVDSHATRKPGSVSGTRRPPIP---HRHSSTRPVSPERRPLPPNNV 535
Cdd:PHA03247 2955 PSGAVPQPWLGaLVPGRVAVPRfrvpQPAPSREAPASSTPPLTGHSLSRVSSWASSlalHEETDPPPVSLKQTLWPPDDT 3034

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  536 TGKPGRAGIVSSSRVTSpplKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSP 595
Cdd:PHA03247 3035 EDSDADSLFDSDSERSD---LEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
PHA03247 PHA03247
large tegument protein UL36; Provisional
 312-514 6.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  312 AESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEP-------VPKEPLHTTSKPKMPPSPEVADTTSAPLETRG 384
Cdd:PHA03247  254 APAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPdgvwgaaLAGAPLALPAPPDPPPPAPAGDAEEEDDEDGA 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  385 IPLI-PVisPRPSQeELQTAMEE------TDQSTQELFTT--KIPRTTELAKTTQAPHRLHTAPV------------RPR 443
Cdd:PHA03247  334 MEVVsPL--PRPRQ-HYPLGFPKrrrptwTPPSSLEDLSAgrHHPKRASLPTRKRRSARHAATPFargpggddqtrpAAP 410

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568995656  444 IPGRP--HGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDS--HATRKPGSVSGTRRPPIP 514
Cdd:PHA03247  411 VPASVptPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDpdDATRKALDALRERRPPEP 485
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 308-609 1.17e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  308 LALPAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTT----SKPKMPPSPEVADTTSAPLETR 383
Cdd:PHA03307  176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAAddagASSSDSSSSESSGCGWGPENEC 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  384 GIPL-IPVISPRPSQEELQTAMEETDqstqelfttkiprttelaKTTQAPHRLHTAPVRPRIPGRPHGRPAlnktTTRPD 462
Cdd:PHA03307  256 PLPRpAPITLPTRIWEASGWNGPSSR------------------PGPASSSSSPRERSPSPSPSSPGSGPA----PSSPR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  463 KTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPlPPNNVTGKPGRA 542
Cdd:PHA03307  314 ASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA-SAGRPTRRRARA 392

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995656  543 GIVSSSRV--TSPPLkatlhPIGTATARPGAEQKEPTAPASEEEFGTTtdfSSSPTKETDPL--GKPRFIG 609
Cdd:PHA03307  393 AVAGRARRrdATGRF-----PAGRPRPSPLDAGAASGAFYARYPLLTP---SGEPWPGSPPPppGRVRYGG 455
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
645-744 1.26e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.07  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 645 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 723
Cdd:COG3979    2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                         90       100
                 ....*....|....*....|.
gi 568995656 724 nplgeGPASNTVAFSTESADP 744
Cdd:COG3979   72 -----DAAGNVSAASGTSTAM 87
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
337-516 1.78e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 41.57  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  337 PPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLI------------PVISPRPSQEELQTam 404
Cdd:pfam05539 168 PKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVgtqgtttssnpePQTEPPPSQRGPSG-- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  405 eetdqSTQELFTTKIPRTtelakTTQAPHRLHTApvRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPK 484
Cdd:pfam05539 246 -----SPQHPPSTTSQDQ-----STTGDGQEHTQ--RRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGS 313

                         170       180       190
                  ....*....|....*....|....*....|..
gi 568995656  485 PPSPGRNASVDSHATRKPGSVSGTRRPPIPHR 516
Cdd:pfam05539 314 SPPHSSPPGVQANPTTQNLVDCKELDPPKPNS 345
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 323-542 7.25e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  323 AGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVP--------KEPLHTTSKP------KMPPSPEVADTTSAPLETRGIPLI 388
Cdd:pfam03154 333 QLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPqlpnpqshKHPPHLSGPSpfqmnsNLPPPPALKPLSSLSTHHPPSAHP 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  389 PVISPRPSQEELQTAMEETDQSTQelfTTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRG 468
Cdd:pfam03154 413 PPLQLMPQSQQLPPPPAQPPVLTQ---SQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAM 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656  469 TshkngvgtgTKQAPKPPSPGRNASVdshatrkPGSVSGTRRP------PIPHRHSSTRPVSPERRPLPPNNVTGKPGRA 542
Cdd:pfam03154 490 P---------GIQPPSSASVSSSGPV-------PAAVSCPLPPvqikeeALDEAEEPESPPPPPRSPSPEPTVVNTPSHA 553
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 311-605 9.13e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 39.67  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 311 PAESKTPEVEKLAG-----QPVTAPRQTT--SMPPKLKTPhsRMPAKEPVPKEPLhTTSKPKMPPSPEVADTTSAP---- 379
Cdd:PTZ00449 549 PGETKEGEVGKKPGpakehKPSKIPTLSKkpEFPKDPKHP--KDPEEPKKPKRPR-SAQRPTRPKSPKLPELLDIPkspk 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 380 -LETRGIPLIPVISPRPSqeelqtameetdqSTQELFTTKIPRTTElakttqaphrlhtAPVRPRIPGRPHGRPAL---- 454
Cdd:PTZ00449 626 rPESPKSPKRPPPPQRPS-------------SPERPEGPKIIKSPK-------------PPKSPKPPFDPKFKEKFyddy 679

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 455 ---------NKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIphrHSSTRPVSP 525
Cdd:PTZ00449 680 ldaaakskeTKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDI---EFFTPPEEE 756

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995656 526 ERRPLPPNNVTGKPGragiVSSSRVTSPPLKATLHPIGTATARPGAEQK-EPTAPA-----------SEEEFGTTTDFSS 593
Cdd:PTZ00449 757 RTFFHETPADTPLPD----ILAEEFKEEDIHAETGEPDEAMKRPDSPSEhEDKPPGdhpslpkkrhrLDGLALSTTDLES 832

                        330
                 ....*....|...
gi 568995656 594 SPTK-ETDPLGKP 605
Cdd:PTZ00449 833 DAGRiAKDASGKI 845
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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