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Conserved domains on  [gi|568995632|ref|XP_006522336|]
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target of Nesh-SH3 isoform X28 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 507-916 2.31e-15

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995632  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1264 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1341
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995632 1342 LGEGPASNTVAFST 1355
Cdd:cd00063    80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1033-1267 5.77e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1033 ELVAFSTESPQKTIAPHRLHTAPVRPRIPGRPHGRP---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnAS 1109
Cdd:PHA03247 2542 ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LP 2618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1110 VDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQ 1189
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568995632 1190 KEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1267
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
fn3 pfam00041
Fibronectin type III domain;
116-195 1.65e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995632   193 GVK 195
Cdd:pfam00041   72 RVQ 74
PRK11633 super family cl25866
cell division protein DedD; Provisional
 451-539 6.58e-03

cell division protein DedD; Provisional


The actual alignment was detected with superfamily member PRK11633:

Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995632  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-916 2.31e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995632  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1264 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1341
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995632 1342 LGEGPASNTVAFST 1355
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1265-1345 7.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 7.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   1265 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1342
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568995632   1343 GEG 1345
Cdd:smart00060   81 GEG 83
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-758 9.37e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.62  E-value: 9.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPE-----PETRPSAQT----TKAPRKTKKPGHhrLRRPKTTRSPEVP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPaplsmPHIKPPPTTpipqLPNPQSHKHPPH--LSGPSPFQMNSNL 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   563 KSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPahepvtfgseapalaivtttdiePVITRTKASVTTLAPK 642
Cdd:pfam03154  391 PPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP-----------------------PVLTQSQSLPPPAASH 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   643 PPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAP 722
Cdd:pfam03154  448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA 523

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 568995632   723 gttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  524 -----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
fn3 pfam00041
Fibronectin type III domain;
1265-1348 1.03e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  1265 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1341
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 568995632  1342 LGEGPAS 1348
Cdd:pfam00041   79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1033-1267 5.77e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1033 ELVAFSTESPQKTIAPHRLHTAPVRPRIPGRPHGRP---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnAS 1109
Cdd:PHA03247 2542 ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LP 2618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1110 VDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQ 1189
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568995632 1190 KEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1267
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 1.10e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 46.69  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839  286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839  365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568995632  648 THRQRTKYKttqspkiPHSKPADLGPITSEPPLASTTKKVRRP---RPKPQTTPHPEVP 703
Cdd:NF033839  431 VKPQPEKPK-------PEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKP 482
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1249-1360 1.49e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1249 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1328
Cdd:COG3401   220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568995632 1329 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1360
Cdd:COG3401   295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
116-195 1.65e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995632   193 GVK 195
Cdd:pfam00041   72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.30e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.30e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632    114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 568995632    190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.36e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                  ....
gi 568995632  192 FGVK 195
Cdd:cd00063    72 FRVR 75
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 1.78e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 43.11  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665   208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665   288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665   364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665   416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665   496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
PRK11633 PRK11633
cell division protein DedD; Provisional
 451-539 6.58e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995632  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-916 2.31e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995632  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 509-776 6.42e-13

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 73.96  E-value: 6.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  509 TPKRQSTPKPPRV-----KPAPEPETRPSA--QTTKAPRKTKKPGHHRlrRPKTTRSPEVPKS--KPALEPATVTPEIL- 578
Cdd:PTZ00449  542 EPKEGGKPGETKEgevgkKPGPAKEHKPSKipTLSKKPEFPKDPKHPK--DPEEPKKPKRPRSaqRPTRPKSPKLPELLd 619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  579 VPKiVPKPPQKPKATRRPevpqvkpahepvtfgseapalaivtttdiepvitrtkasvttlaPKPPRPRTHRQRTKYKTT 658
Cdd:PTZ00449  620 IPK-SPKRPESPKSPKRP--------------------------------------------PPPQRPSSPERPEGPKII 654

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  659 QSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPgTTLVPKLPQQPDYPH 738
Cdd:PTZ00449  655 KSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPKLPRDEEFPF 733

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 568995632  739 PKPKTTRSPAASPTELVPTPVfEPVTPLKEDPVTTIVP 776
Cdd:PTZ00449  734 EPIGDPDAEQPDDIEFFTPPE-EERTFFHETPADTPLP 770
PHA03247 PHA03247
large tegument protein UL36; Provisional
 448-743 1.69e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  448 TATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEP 527
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  528 ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKP-ALEPATVTPEILVP---KIVPKPPQKPKATRRPEVPQVKP 603
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaAALPPAASPAGPLPpptSAQPTAPPPPPGPPPPSLPLGGS 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  604 AHEPVTFGSEAPALAIVTTtdiepVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAST 683
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAK-----PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995632  684 TKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGTTLVPKL---PQQPDYPHPKPKT 743
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrvpQPAPSREAPASST 2993
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1264 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1341
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995632 1342 LGEGPASNTVAFST 1355
Cdd:cd00063    80 GGESPPSESVTVTT 93
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 494-844 2.12e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 58.93  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  494 RPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEpetrpSAQTTKAPRKTKKPGhhRLRRPKTTRSPEVPKSKPALEPATV 573
Cdd:PTZ00449  560 KPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPE-----EPKKPKRPRSAQRPT--RPKSPKLPELLDIPKSPKRPESPKS 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  574 tpeilvPKiVPKPPQKPKATRRPEVPQV----KPAHEP-VTFGseaPALAIVTTTDIEPVITRTKASVTTLAPKpprpRT 648
Cdd:PTZ00449  633 ------PK-RPPPPQRPSSPERPEGPKIikspKPPKSPkPPFD---PKFKEKFYDDYLDAAAKSKETKTTVVLD----ES 698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  649 HRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTT--KKVRRPRPKPQTTPHPEVPHTILV---PATSLEPFIITEAPG 723
Cdd:PTZ00449  699 FESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEpiGDPDAEQPDDIEFFTPPEEERTFFhetPADTPLPDILAEEFK 778

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  724 TTLVPKLPQQPDYPHPKPKttrspaaSPTELVPTPVFE-PVTPLK----------------------EDPVTTIVPITDL 780
Cdd:PTZ00449  779 EEDIHAETGEPDEAMKRPD-------SPSEHEDKPPGDhPSLPKKrhrldglalsttdlesdagriaKDASGKIVKLKRS 851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  781 ERVTDLET--------PVAFR-------TEAPGT-TLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVV 844
Cdd:PTZ00449  852 KSFDDLTTveeaeemgAEARKivvdddgTEADDEdTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSII 931
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 381-767 4.70e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 58.16  E-value: 4.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  381 KRFPEFPEAKTAFPLEKPRGSWASSEEPwVVPGAKTSEdSRVVQPQTATYDVISSSTTSDETEIEI---------HTATR 451
Cdd:PTZ00449  494 KKLAPIEEEDSDKHDEPPEGPEASGLPP-KAPGDKEGE-EGEHEDSKESDEPKEGGKPGETKEGEVgkkpgpakeHKPSK 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  452 DPILDSVP-----PKTSRTAEQPRATLAPIEAlfesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRvkpAPE 526
Cdd:PTZ00449  572 IPTLSKKPefpkdPKHPKDPEEPKKPKRPRSA-----------QRPTRPKSPKLPELLDIPKSPKRPESPKSPK---RPP 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  527 PETRPSAQttkaprktkkpghhrlRRPKTTRSPEVPKSKPAlepatvtpeilvpkivPKPPQKPKATRRPEVPQVKPAHE 606
Cdd:PTZ00449  638 PPQRPSSP----------------ERPEGPKIIKSPKPPKS----------------PKPPFDPKFKEKFYDDYLDAAAK 685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  607 PVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPP-RPRThrqrtkykttqsPKIPHSKPADlgpitsePPLASTTK 685
Cdd:PTZ00449  686 SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPkLPRD------------EEFPFEPIGD-------PDAEQPDD 746

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  686 KVRRPRPKPQTTPHPEvphtilVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKttrspaaSPTELVPTPVFE-PVT 764
Cdd:PTZ00449  747 IEFFTPPEEERTFFHE------TPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPD-------SPSEHEDKPPGDhPSL 813


                  ...
gi 568995632  765 PLK 767
Cdd:PTZ00449  814 PKK 816
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1265-1345 7.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 7.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   1265 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1342
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568995632   1343 GEG 1345
Cdd:smart00060   81 GEG 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-1211 9.28e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 9.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  545 PGHHRLRRPKTTRSPEVPKSKPalEPATVTPEilvPKIVPKPPQKPKATRRPEVPQVKPAHEPV-------------TFG 611
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAP--DPGGGGPP---DPDAPPAPSRLAPAILPDEPVGEPVHPRMltwirgleelasdDAG 2549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  612 SEAPALAivttTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPitsepplasttkkvrrPR 691
Cdd:PHA03247 2550 DPPPPLP----PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGD----------------PR 2609

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  692 PKPQTTPHPEVPHTILVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPV 771
Cdd:PHA03247 2610 GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  772 TTIVPITDLErvtdletpvafRTEAPGTTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVtlR 851
Cdd:PHA03247 2690 PTVGSLTSLA-----------DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA--R 2756

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  852 PEVQVTTLAPqktqkkhrpspkpkpvpspevteSKPVLPRVREPVTLRTETwVTTKAPKTPKRTRRPRPKPQTTPTPETP 931
Cdd:PHA03247 2757 PARPPTTAGP-----------------------PAPAPPAAPAAGPPRRLT-RPAVASLSESRESLPSPWDPADPPAAVL 2812

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  932 LTKPVAATDLEPSALSTEVPATVVLATALTPVTLRTKAPKTTTLAPNVQRTRRPHPRPKTTASTGVSESKSaptelqSLV 1011
Cdd:PHA03247 2813 APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPV------RRL 2886

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1012 LKPVTSPSLEiiqSQSVSDDLELVAFSTESPQKTIAPHRLHTAPV---RPRIPGRPHGRPALNKTTTRPDKTKPRGTSHK 1088
Cdd:PHA03247 2887 ARPAVSRSTE---SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQpqpPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW 2963

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1089 NG-VGTGTKQAPK----PPSPGRNASVDSHATRKPGSVSGTRRPPIP---HRHSSTRPVSPERRPLPPNNVTGKPGRAGI 1160
Cdd:PHA03247 2964 LGaLVPGRVAVPRfrvpQPAPSREAPASSTPPLTGHSLSRVSSWASSlalHEETDPPPVSLKQTLWPPDDTEDSDADSLF 3043

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568995632 1161 VSSSRVTSpplKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSP 1211
Cdd:PHA03247 3044 DSDSERSD---LEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-758 9.37e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.62  E-value: 9.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPE-----PETRPSAQT----TKAPRKTKKPGHhrLRRPKTTRSPEVP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPaplsmPHIKPPPTTpipqLPNPQSHKHPPH--LSGPSPFQMNSNL 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   563 KSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPahepvtfgseapalaivtttdiePVITRTKASVTTLAPK 642
Cdd:pfam03154  391 PPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP-----------------------PVLTQSQSLPPPAASH 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   643 PPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAP 722
Cdd:pfam03154  448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA 523

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 568995632   723 gttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  524 -----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
fn3 pfam00041
Fibronectin type III domain;
1265-1348 1.03e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  1265 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1341
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 568995632  1342 LGEGPAS 1348
Cdd:pfam00041   79 GGEGPPS 85
PHA03377 PHA03377
EBNA-3C; Provisional
 517-761 2.29e-06

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 52.36  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  517 KPPRVKPAPEPETRPSAQT---TKAPRKTKKPGHHRLRRPKTTRSPEVPkskpaLEPATVTPEILVPKIVPKPPQKPKAT 593
Cdd:PHA03377  414 RKPRTLPWPTPKTHPVKRTlvkTSGRSDEAEQAQSTPERPGPSDQPSVP-----VEPAHLTPVEHTTVILHQPPQSPPTV 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  594 rrpevpQVKPAHEPVTFGSEApalAIVTTTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPK---IPHSKPAD 670
Cdd:PHA03377  489 ------AIKPAPPPSRRRRGA---CVVYDDDIIEVIDVETTEEEESVTQPAKPHRKVQDGFQRSGRRQKratPPKVSPSD 559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  671 LGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPhtilvpatslepfiitEAPGTTLVPKLPQQPdyPHPKPKTTRSPAAS 750
Cdd:PHA03377  560 RGPPKASPPVMAPPSTGPRVMATPSTGPRDMAP----------------PSTGPRQQAKCKDGP--PASGPHEKQPPSSA 621

                         250
                  ....*....|.
gi 568995632  751 PTELVPTPVFE 761
Cdd:PHA03377  622 PRDMAPSVVRM 632
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1033-1267 5.77e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1033 ELVAFSTESPQKTIAPHRLHTAPVRPRIPGRPHGRP---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnAS 1109
Cdd:PHA03247 2542 ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LP 2618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1110 VDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQ 1189
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568995632 1190 KEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1267
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 709-1286 5.49e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 5.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  709 PATSLEPFIITEAPGttlvPKLPQQPDYPHPKPKTTRSPAASPTElvptPVFEPVTP--------LKE-------DPVTT 773
Cdd:PHA03247 2483 PAEARFPFAAGAAPD----PGGGGPPDPDAPPAPSRLAPAILPDE----PVGEPVHPrmltwirgLEElasddagDPPPP 2554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  774 IVPitdlervtdLETPVAFRTEAPGTTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPE 853
Cdd:PHA03247 2555 LPP---------AAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  854 VQVTTLAPQKTQKkhrPSPKPKPVPSPEVTESKPVLPRVREPVTLRTETWVTTKAPKTPKRTRRPRPKPQTTPTPETPLT 933
Cdd:PHA03247 2626 PPPPSPSPAANEP---DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPP 2702

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  934 KPVAATDLEPSALSTEVPATVVLATA--LTPVTLRTKAPKTTTLAPNVQRTRRPHPRPKTTASTGVSESKSAPTELQSLV 1011
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAArqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1012 LKPVTSPSLeiiqsqsvsddlelvAFSTESPQKTIAPHRlHTAPVRPRIPGRPhgrpalnkTTTRPDKTKPRGTshkngv 1091
Cdd:PHA03247 2783 LTRPAVASL---------------SESRESLPSPWDPAD-PPAAVLAPAAALP--------PAASPAGPLPPPT------ 2832

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1092 gTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPL 1171
Cdd:PHA03247 2833 -SAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1172 KATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiPKPENKPCSITDSVRRFPTE 1251
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----PWLGALVPGRVAVPRFRVPQ 2981

                         570       580       590
                  ....*....|....*....|....*....|....*
gi 568995632 1252 EATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1286
Cdd:PHA03247 2982 PAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 1.10e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 46.69  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839  286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839  365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568995632  648 THRQRTKYKttqspkiPHSKPADLGPITSEPPLASTTKKVRRP---RPKPQTTPHPEVP 703
Cdd:NF033839  431 VKPQPEKPK-------PEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKP 482
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1249-1360 1.49e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1249 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1328
Cdd:COG3401   220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568995632 1329 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1360
Cdd:COG3401   295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
116-195 1.65e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995632   193 GVK 195
Cdd:pfam00041   72 RVQ 74
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1249-1403 2.02e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1249 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 1326
Cdd:COG3401   314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568995632 1327 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1403
Cdd:COG3401   388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.30e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.30e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632    114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 568995632    190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.36e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                  ....
gi 568995632  192 FGVK 195
Cdd:cd00063    72 FRVR 75
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 515-626 3.82e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.80  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKttrsPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATR 594
Cdd:PRK14950  361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPK----EPVRETAT---PPPVPPRPVAPPVPHTPESAPKLTR 433

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568995632  595 RPEVPQVKPAHEPVTFGSEAPALAIVTTTDIE 626
Cdd:PRK14950  434 AAIPVDEKPKYTPPAPPKEEEKALIADGDVLE 465
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 553-775 4.84e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.53  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  553 PKTTRSPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATRRPEVP-----QVKPAHEPVTFGSEAPALAIVTTTDIEP 627
Cdd:PLN03209  330 PKESDAADGPKPVP---TKPVTPEAPSPPIEEEPPQPKAVVPRPLSPytayeDLKPPTSPIPTPPSSSPASSKSVDAVAK 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  628 VITRTKASVTTLAPKPPRPRTHRQRTKyktTQSPKIPHSKPADLGPITSepplasttkkvrrPRPKPQTTPHPEVPHTIL 707
Cdd:PLN03209  407 PAEPDVVPSPGSASNVPEVEPAQVEAK---KTRPLSPYARYEDLKPPTS-------------PSPTAPTGVSPSVSSTSS 470

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995632  708 VPATSLEP----FIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIV 775
Cdd:PLN03209  471 VPAVPDTApataATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
PHA03378 PHA03378
EBNA-3B; Provisional
 491-705 5.57e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 5.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  491 PEVRPTTAapQQTTSIPSTPKRqSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGH----HRLRRPKTTRSPEV---PK 563
Cdd:PHA03378  576 PLTSPTTS--QLASSAPSYAQT-PWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRpipmRPLRMQPITFNVLVfptPH 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  564 SKPALEPATVTPEILVPKIVP-----------KPPQKPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRT 632
Cdd:PHA03378  653 QPPQVEITPYKPTWTQIGHIPyqpsptgantmLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG 732

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995632  633 KASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHT 705
Cdd:PHA03378  733 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPT 805
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 491-766 7.75e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 7.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQP 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   571 ATVT--PEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPvtfgseapalaivtttdiepvitrtkasvttlAPKPPRPRT 648
Cdd:pfam03154  252 MTQPppPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ--------------------------------HPVPPQPFP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632   649 hrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPkPQTTPHPEVPhtilVPATSLEPfiiteaPGTTLVP 728
Cdd:pfam03154  300 ----LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-PREQPLPPAP----LSMPHIKP------PPTTPIP 364

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568995632   729 KLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPL 766
Cdd:pfam03154  365 QLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSL 402
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 420-747 8.21e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 8.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  420 SRVVQPQTATYDVISSSTTSDE---------TEIEIHTATRDPILDSVPPKTSRTA-EQPRATLAPIEALFESRNVeIFT 489
Cdd:PRK10263  297 NRATQPEYDEYDPLLNGAPITEpvavaaaatTATQSWAAPVEPVTQTPPVASVDVPpAQPTVAWQPVPGPQTGEPV-IAP 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  490 SPEVRPTTAAPQQTTSIPSTPKRQSTP--KPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:PRK10263  376 APEGYPQQSQYAQPAVQYNEPLQQPVQpqQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQST 455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  568 LEP-ATVTPEILVPKIVPKPP---------QKPKATRRPEVPQVKPAHEPVTFGSEapalaivtttdIEPVITRTKASVT 637
Cdd:PRK10263  456 FAPqSTYQTEQTYQQPAAQEPlyqqpqpveQQPVVEPEPVVEETKPARPPLYYFEE-----------VEEKRAREREQLA 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  638 TLAPKPPRPrthrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRrprpkpQTTPHPEVPHTILVPATSLepfi 717
Cdd:PRK10263  525 AWYQPIPEP------VKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVK------KATLATGAAATVAAPVFSL---- 588

                         330       340       350
                  ....*....|....*....|....*....|
gi 568995632  718 iteAPGTTLVPKLPQQPDYPHPKPKTTRSP 747
Cdd:PRK10263  589 ---ANSGGPRPQVKEGIGPQLPRPKRIRVP 615
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
458-771 9.27e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  458 VPPKTSRTAEQPRATLAP---IEALFESRNVEIFTSPEVRPTTAAPQQTTsIPSTPKRQSTPKP-------PRVKPAPEP 527
Cdd:PRK07003  372 VPARVAGAVPAPGARAAAavgASAVPAVTAVTGAAGAALAPKAAAAAAAT-RAEAPPAAPAPPAtadrgddAADGDAPVP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  528 ---ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQ--------KPKATRRP 596
Cdd:PRK07003  451 akaNARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAaasredapAAAAPPAP 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  597 EVPQVKPA--HEPVTFGSEAPALAIVTTTDIEPVITRTK--------ASVTTLAPKPPRPRTHRQrtkyktTQSPKIPHS 666
Cdd:PRK07003  531 EARPPTPAaaAPAARAGGAAAALDVLRNAGMRVSSDRGAraaaaakpAAAPAAAPKPAAPRVAVQ------VPTPRARAA 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  667 KPADLGPITSEPPLASTTkkvRRPRPkpqttPHPEVPHTILVPATSLEPFIiteAPGTTLVPKLPQQPDYPHPKPKTTRS 746
Cdd:PRK07003  605 TGDAPPNGAARAEQAAES---RGAPP-----PWEDIPPDDYVPLSADEGFG---GPDDGFVPVFDSGPDDVRVAPKPADA 673

                         330       340
                  ....*....|....*....|....*
gi 568995632  747 PAAsPTELVPTPvfePVTPLkeDPV 771
Cdd:PRK07003  674 PAP-PVDTRPLP---PAIPL--DAI 692
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1044-1254 1.29e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1044 KTIAPHRLHTAPVRPRIPGRPHGrPALNKTTTRPDKTKprgtSHKNGVgtgTKQAP-KPPSPGRNASVD-SHATRKPGSV 1121
Cdd:PTZ00449  559 KKPGPAKEHKPSKIPTLSKKPEF-PKDPKHPKDPEEPK----KPKRPR---SAQRPtRPKSPKLPELLDiPKSPKRPESP 630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1122 SGTRRPPIPhrhssTRPVSPERRPLPPNNVTGKPGRagivSSSRVTSPPLKATLHpigTATARPGAEQKEPTAPASEEEF 1201
Cdd:PTZ00449  631 KSPKRPPPP-----QRPSSPERPEGPKIIKSPKPPK----SPKPPFDPKFKEKFY---DDYLDAAAKSKETKTTVVLDES 698

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568995632 1202 GTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEAT 1254
Cdd:PTZ00449  699 FESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFT 751
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 490-618 1.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  490 SPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEV-PKSKPAL 568
Cdd:PRK07994  370 VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSePAAASRA 449

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568995632  569 EPATVTPEIL-----VPKIVPKPPQKPKATR-RPEVPQVKPAHEPVTFGSEAPALA 618
Cdd:PRK07994  450 RPVNSALERLasvrpAPSALEKAPAKKEAYRwKATNPVEVKKEPVATPKALKKALE 505
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 480-628 1.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.87  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  480 FESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPghhrLRRPKTTRSP 559
Cdd:PRK14950  351 LELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRP----VAPPVPHTPE 426

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995632  560 EVPKSKPALEPATVTPEILVPkivPKPPQKPKATRRPEV--PQVKPAHEPVT--FGSEAPALAIVTTTDIEPV 628
Cdd:PRK14950  427 SAPKLTRAAIPVDEKPKYTPP---APPKEEEKALIADGDvlEQLEAIWKQILrdVPPRSPAVQALLSSGVRPV 496
dnaA PRK14086
chromosomal replication initiator protein DnaA;
515-718 1.55e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.89  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKP----GHHRL--RRPKTTRSPEVPKSKPALEPATVTPEilvPKIVPKPP- 587
Cdd:PRK14086   87 TVDPSAGEPAPPPPHARRTSEPELPRPGRRPyegyGGPRAddRPPGLPRQDQLPTARPAYPAYQQRPE---PGAWPRAAd 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  588 ----QKPKATRRPEVPQVKPAHEPVTFGSEAPALAivtttDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKI 663
Cdd:PRK14086  164 dygwQQQRLGFPPRAPYASPASYAPEQERDREPYD-----AGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHV 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568995632  664 PHSKPADLGPItSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFII 718
Cdd:PRK14086  239 HRGGPGPPERD-DAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYTFDTFVI 292
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 511-1079 1.55e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  511 KRQSTPKPPRVKPAPE--PETRPSAQTTKAPRK-TKKPGHHRlrRPKTTRSPEVPKsKPAlePATVTPEILVPKIVPKP- 586
Cdd:PTZ00449  506 KHDEPPEGPEASGLPPkaPGDKEGEEGEHEDSKeSDEPKEGG--KPGETKEGEVGK-KPG--PAKEHKPSKIPTLSKKPe 580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  587 -PQKPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPP-RPRTHRQRTKYKTTQSPKIP 664
Cdd:PTZ00449  581 fPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPqRPSSPERPEGPKIIKSPKPP 660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  665 HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPgTTLVPKLPQQPDYPHPKPKTT 744
Cdd:PTZ00449  661 KSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPKLPRDEEFPFEPIGDP 739

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  745 RSPAASPTELVPTPVfepvtplkedpvttivpitdLERVTDLETPVafRTEAPGTTlaskisqrthrprprprprprprp 824
Cdd:PTZ00449  740 DAEQPDDIEFFTPPE--------------------EERTFFHETPA--DTPLPDIL------------------------ 773

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  825 rpkatlspqAPETKTvpavvlepvtlrPEVQVTTLAPQKTQKKhrpspkpkpvpspevteskPVLPRVREPVTlrtetwv 904
Cdd:PTZ00449  774 ---------AEEFKE------------EDIHAETGEPDEAMKR-------------------PDSPSEHEDKP------- 806

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  905 TTKAPKTPKRTRRPRPKPqttptpetpltkpVAATDLEPSalstevPATVVLATALTPVTLRtkapktttlapnvqrtrr 984
Cdd:PTZ00449  807 PGDHPSLPKKRHRLDGLA-------------LSTTDLESD------AGRIAKDASGKIVKLK------------------ 849

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  985 phprpkttastgvsESKSApTELQSLVLKPVTSPSLEIIqsqSVSDDlelvafSTESP-QKTIAPHRLHTAPVRPRIPGR 1063
Cdd:PTZ00449  850 --------------RSKSF-DDLTTVEEAEEMGAEARKI---VVDDD------GTEADdEDTHPPEEKHKSEVRRRRPPK 905

                         570
                  ....*....|....*.
gi 568995632 1064 PHGRPALNKTTTRPDK 1079
Cdd:PTZ00449  906 KPSKPKKPSKPKKPKK 921
PHA03369 PHA03369
capsid maturational protease; Provisional
 491-779 1.61e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 43.06  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PHA03369  362 AAAKVAVIAAPQTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGPVPPQPT 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  571 ATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPVTFGSEAPalaivtTTDIEPVITRTKASVTTLAPKPPRPRTHR 650
Cdd:PHA03369  442 NPYVMPISMANMVYPGHPQEHGHERKRKRGGELKEELIETLKLVK------KLKEEQESLAKELEATAHKSEIKKIAESE 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  651 QRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGT------ 724
Cdd:PHA03369  516 FKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTaealag 595

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568995632  725 ---TLVPKLPQQPDYPHpkpktTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPITD 779
Cdd:PHA03369  596 aieTLLTQASAQPAGLS-----LPAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLE 648
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 1.78e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 43.11  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665   208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665   288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665   364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665   416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665   496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
PHA03247 PHA03247
large tegument protein UL36; Provisional
 531-802 2.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  531 PSAQTTKAPRKTKKPGHHRlrrpKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPqvkPAHEPVTF 610
Cdd:PHA03247  255 PAPPPVVGEGADRAPETAR----GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPA---PAGDAEEE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  611 GSEAPALAIVTttdiePVitrtkasvttlapkpPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRp 690
Cdd:PHA03247  328 DDEDGAMEVVS-----PL---------------PRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRASLPTRKRR- 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  691 rpkpqTTPHPEVPHTiLVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:PHA03247  387 -----SARHAATPFA-RGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATE 460

                         250       260       270
                  ....*....|....*....|....*....|...
gi 568995632  771 VTTivPITDLERVTDLETPVAFRT-EAPGTTLA 802
Cdd:PHA03247  461 PAP--DDPDDATRKALDALRERRPpEPPGADLA 491
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 469-600 2.63e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  469 PRATLAPIEALfESRNV----EIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVkPAPEPETRPSAQTTKAPRKTKK 544
Cdd:PRK07764  371 ERGLLARLERL-ERRLGvaggAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPA-AAPQPAPAPAPAPAPPSPAGNA 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568995632  545 PGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQ 600
Cdd:PRK07764  449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 515-612 3.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.24  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  515 TPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGhhrlRRPKTTRSPEvpkSKPAlePATVTPeilVPKIVPKPPqKPKATR 594
Cdd:PRK14954  385 AGSPDVKKKAPEPDL-PQPDRHPGPAKPEAPG----ARPAELPSPA---SAPT--PEQQPP---VARSAPLPP-SPQASA 450

                          90
                  ....*....|....*...
gi 568995632  595 RPEVPQVKPAhepVTFGS 612
Cdd:PRK14954  451 PRNVASGKPG---VDLGS 465
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
491-673 3.80e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PRK12323  383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAA 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  571 ATVTPEIL---VPKIVPKPPQKPKATRRPEVPQVKPAHE-PVTFGSEAPA------LAIVTTTDIEPVITRTKASVTTLA 640
Cdd:PRK12323  463 RPAAAGPRpvaAAAAAAPARAAPAAAPAPADDDPPPWEElPPEFASPAPAqpdaapAGWVAESIPDPATADPDDAFETLA 542

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568995632  641 PKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGP 673
Cdd:PRK12323  543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 471-748 3.95e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  471 ATLAPIEALFESrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPEtRPSAQttkAPRKTKKPGHHRL 550
Cdd:PLN03209  311 APLTPMEELLAK-------IPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPP-QPKAV---VPRPLSPYTAYED 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  551 RRPKTTRSPEVPKSKPA----------LEPATVTPEILVPKIVP--KPPQKPKATRRPEVPQVK-PAHEPVTFGSEAPAL 617
Cdd:PLN03209  380 LKPPTSPIPTPPSSSPAssksvdavakPAEPDVVPSPGSASNVPevEPAQVEAKKTRPLSPYARyEDLKPPTSPSPTAPT 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  618 AIVTTTDIEPVITRT------KASVTTLAPKPPRPRthrqrtkykttqsPKIPHSKPADLGPITSEPPLAsttkkvrrPR 691
Cdd:PLN03209  460 GVSPSVSSTSSVPAVpdtapaTAATDAAAPPPANMR-------------PLSPYAVYDDLKPPTSPSPAA--------PV 518

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995632  692 PKPQTTPHPEVPhtilvPATSLEPFIITEAPGTTLVPKlpQQPDYPHP-----KPKTTRSPA 748
Cdd:PLN03209  519 GKVAPSSTNEVV-----KVGNSAPPTALADEQHHAQPK--PRPLSPYTmyedlKPPTSPTPS 573
PRK11633 PRK11633
cell division protein DedD; Provisional
 451-539 6.58e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995632  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1266-1360 9.68e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 40.14  E-value: 9.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995632 1266 PTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKnplge 1344
Cdd:COG3979     6 PTGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC----- 71

                          90
                  ....*....|....*.
gi 568995632 1345 GPASNTVAFSTESADP 1360
Cdd:COG3979    72 DAAGNVSAASGTSTAM 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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