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Conserved domains on  [gi|568994982|ref|XP_006522026|]
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cilia- and flagella-associated protein 44 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
113-484 2.10e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 2.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  113 VDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAftfTGlKLQGS 192
Cdd:COG2319    84 VAFSPDGRLLASAS--ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TG-KLLRT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  193 LgrfgKTSTSDIEGYAELPDGKVL-SGSEWGNLLLWE---GSLIKVelcRTGmkscHSGSINQIML--DEGEVITAGSDG 266
Cdd:COG2319   158 L----TGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDlatGKLLRT---LTG----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  267 SVRIWDFETIDTADVIDDTGlleiEPINelhidkSVNlFSmikmnevGNNFWLA---QDANGAIWKLDlsfsniTQDPEC 343
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHS----GSVR------SVA-FS-------PDGRLLAsgsADGTVRLWDLA------TGELLR 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  344 LFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKfkqGGTSLIWaprSVSVSA--SQIVVGFQDGVVRV 421
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVR---SVAFSPdgKTLASGSDDGTVRL 356

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994982  422 LELFDPKGLTVYAGrkkipdaelhlkyvfkpHTDEVTALAYERDGDILATGSEDKTVFFFDVE 484
Cdd:COG2319   357 WDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1437-1705 6.11e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 51.22  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1437 EKRLDIEEALVEEKKI-VDNLKKE------YDTISKK-----VKVVATNLNAAEEALEAYQRE------KQQRLNELLVV 1498
Cdd:TIGR02169  183 EENIERLDLIIDEKRQqLERLRRErekaerYQALLKEkreyeGYELLKEKEALERQKEAIERQlasleeELEKLTEEISE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1499 IPLKLHQIEymefgEVPEDLsgtlvfsNHSLDRL-QERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEET 1577
Cdd:TIGR02169  263 LEKRLEEIE-----QLLEEL-------NKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1578 VRELM--ISKFGRVIDLEALQTLSVNTTLEELKIK--KLRKEL-SNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMND 1652
Cdd:TIGR02169  331 IDKLLaeIEELEREIEEERKRRDKLTEEYAELKEEleDLRAELeEVDKEFAETRDELKDYREKLEKLKREINELKRELDR 410

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568994982  1653 LCLEKKKLDSRLNTLqnqqgnafqglrKADI-VAKQKVTELVQTQLEKITALKE 1705
Cdd:TIGR02169  411 LQEELQRLSEELADL------------NAAIaGIEAKINELEEEKEDKALEIKK 452
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1295-1495 1.74e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1295 LKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQ---EKALYAGFQAALGE-------NNKFANF 1364
Cdd:COG3883    25 LSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaeAEAEIEERREELGEraralyrSGGSVSY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1365 LMKVLKkkikrakkkevegdadedeeseesseeesslesdedaSGSEDDVFDDsicptncdvslFELALQLREKRLDIEE 1444
Cdd:COG3883   105 LDVLLG-------------------------------------SESFSDFLDR-----------LSALSKIADADADLLE 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568994982 1445 ALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNEL 1495
Cdd:COG3883   137 ELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL 187
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 786-1021 3.52e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   786 ESEAAPE-DIEDPKAYSIENARKKREHDKLMKKVEeLKAHKREQIKILRNEFWKLLELNKELpAHMQFQRTDFNidAKIH 864
Cdd:pfam17380  320 EAEKARQaEMDRQAAIYAEQERMAMERERELERIR-QEERKRELERIRQEEIAMEISRMREL-ERLQMERQQKN--ERVR 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   865 AEIHKKTSLKIEQVEKELAWEKQKHEL-GLKKLQDRFREplesDTIVVYATQSDHQIASYRLVKPSKYSKLKRPSQSE-- 941
Cdd:pfam17380  396 QELEAARKVKILEEERQRKIQQQKVEMeQIRAEQEEARQ----REVRRLEEERAREMERVRLEEQERQQQVERLRQQEee 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   942 RRQSKMErLEKEGPGKKESQRdtggsislQEESVLEKGKKFRPRTLSE-----IMVENQIEKTKKLIQQAERAQFKILQR 1016
Cdd:pfam17380  472 RKRKKLE-LEKEKRDRKRAEE--------QRRKILEKELEERKQAMIEeerkrKLLEKEMEERQKAIYEEERRREAEEER 542


                   ....*
gi 568994982  1017 KKEWE 1021
Cdd:pfam17380  543 RKQQE 547
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 684-764 1.19e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  684 NPIRNITFSNDQTMMFCGMTNGAIRVYVLSENDPFLVSLQHYwhfnvhdnnyGSIKSITSSFDDQYLLTAGEDGNIFVFD 763
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT----------GPVRDVAASADGTYLASGSSDKTIRLWD 79


                  .
gi 568994982  764 I 764
Cdd:cd00200    80 L 80
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
113-484 2.10e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 2.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  113 VDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAftfTGlKLQGS 192
Cdd:COG2319    84 VAFSPDGRLLASAS--ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TG-KLLRT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  193 LgrfgKTSTSDIEGYAELPDGKVL-SGSEWGNLLLWE---GSLIKVelcRTGmkscHSGSINQIML--DEGEVITAGSDG 266
Cdd:COG2319   158 L----TGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDlatGKLLRT---LTG----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  267 SVRIWDFETIDTADVIDDTGlleiEPINelhidkSVNlFSmikmnevGNNFWLA---QDANGAIWKLDlsfsniTQDPEC 343
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHS----GSVR------SVA-FS-------PDGRLLAsgsADGTVRLWDLA------TGELLR 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  344 LFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKfkqGGTSLIWaprSVSVSA--SQIVVGFQDGVVRV 421
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVR---SVAFSPdgKTLASGSDDGTVRL 356

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994982  422 LELFDPKGLTVYAGrkkipdaelhlkyvfkpHTDEVTALAYERDGDILATGSEDKTVFFFDVE 484
Cdd:COG2319   357 WDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 211-506 1.24e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  211 PDGKVL-SGSEWGNLLLWEGSLIKVELCRTGmkscHSGSINQIML--DEGEVITAGSDGSVRIWDFETIDTADVIddTGl 287
Cdd:cd00200    19 PDGKLLaTGSGDGTIKVWDLETGELLRTLKG----HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTL--TG- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  288 lEIEPINELHIDKsvnlfsmikmnevgNNFWLA---QDANGAIWKLDlsfsnitqDPECLFSF--HSGPIAALAVSPLTY 362
Cdd:cd00200    92 -HTSYVSSVAFSP--------------DGRILSsssRDKTIKVWDVE--------TGKCLTTLrgHTDWVNSVAFSPDGT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  363 LMATTAMDCSVRVYDFSSKNPL-VHMKFKQGGTSLIWAPRSvsvsaSQIVVGFQDGVVRVLELfdpkgltvyagrkkipd 441
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSPDG-----EKLLSSSSDGTIKLWDL----------------- 206

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994982  442 AELHLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSP 506
Cdd:cd00200   207 STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 445-482 1.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568994982    445 HLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFD 482
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
446-482 2.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 2.77e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568994982   446 LKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFD 482
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1437-1705 6.11e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.22  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1437 EKRLDIEEALVEEKKI-VDNLKKE------YDTISKK-----VKVVATNLNAAEEALEAYQRE------KQQRLNELLVV 1498
Cdd:TIGR02169  183 EENIERLDLIIDEKRQqLERLRRErekaerYQALLKEkreyeGYELLKEKEALERQKEAIERQlasleeELEKLTEEISE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1499 IPLKLHQIEymefgEVPEDLsgtlvfsNHSLDRL-QERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEET 1577
Cdd:TIGR02169  263 LEKRLEEIE-----QLLEEL-------NKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1578 VRELM--ISKFGRVIDLEALQTLSVNTTLEELKIK--KLRKEL-SNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMND 1652
Cdd:TIGR02169  331 IDKLLaeIEELEREIEEERKRRDKLTEEYAELKEEleDLRAELeEVDKEFAETRDELKDYREKLEKLKREINELKRELDR 410

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568994982  1653 LCLEKKKLDSRLNTLqnqqgnafqglrKADI-VAKQKVTELVQTQLEKITALKE 1705
Cdd:TIGR02169  411 LQEELQRLSEELADL------------NAAIaGIEAKINELEEEKEDKALEIKK 452
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1434-1621 1.24e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1434 QLREKRLDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEayqrEKQQRLNELLVVIpLKLHQIEYMEF-- 1511
Cdd:COG4942    52 ALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE----AQKEELAELLRAL-YRLGRQPPLALll 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1512 -GEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETV--RELMISKFGR 1588
Cdd:COG4942   127 sPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKaeRQKLLARLEK 206

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568994982 1589 VIDLEA--LQTLSVNTTLEELKIKKLRKELSNAKE 1621
Cdd:COG4942   207 ELAELAaeLAELQQEAEELEALIARLEAEAAAAAE 241
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 794-1708 1.46e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.97  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   794 IEDPKAYSIENARKKREHDKLMKKVEELKAHKREQIKILRNEFwKLLELNKELPAHMQFQRTDFNIDAKIHAEIHKKTSL 873
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQEL-KLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   874 KIEQVEKELAWEKQKHELGLKKLQDRFREPLEsdtivvyatQSDHQIASYRLVKPSKYSKLKRpSQSERRQSKMERLEKE 953
Cdd:pfam02463  237 ERIDLLQELLRDEQEEIESSKQEIEKEEEKLA---------QVLKENKEEEKEKKLQEEELKL-LAKEEEELKSELLKLE 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   954 GPGKKESQRDTGGSISLQEESVLEKGKKfrprtlsEIMVENQIEKTKKLIQQAERAQfKILQRKKEWEELYKSKPDDDYE 1033
Cdd:pfam02463  307 RRKVDDEEKLKESEKEKKKAEKELKKEK-------EEIEELEKELKELEIKREAEEE-EEEELEKLQEKLEQLEEELLAK 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1034 DPKDVQAIKEAQtymGDFNLKTAPDYKIpehmrINAAKKEEELgyldtmaHGKKRYMNKCILSLRDLKLAVIEEIQCLVQ 1113
Cdd:pfam02463  379 KKLESERLSSAA---KLKEEELELKSEE-----EKEAQLLLEL-------ARQLEDLLKEEKKEELEILEEEEESIELKQ 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1114 ELKNIQSsipaskhmpipqvpqiypeevperrfqyDEETLLRFQRKQKKRQDKSSSKQSGTGSGGSAGGGLVGFLKLSSG 1193
Cdd:pfam02463  444 GKLTEEK----------------------------EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKL 495

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1194 KEGDLTTRDSLSRSSKASALLELPKPVEFEKAEPSDAELEimkrdEVKHLYMQQFLCNRINELTVTFDAELHLLRHQKLK 1273
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLG-----VAVENYKVAISTAVIVEVSATADEVEERQKLVRAL 570

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1274 LDTKMKLSDLHHLTLFQEMLLLKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQEKALYAGFQA 1353
Cdd:pfam02463  571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRK 650

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1354 ALGENNKFANFLMKVLKKKIKRAKKKEVEGDADEDEESEESSEEESSLESDEDASGS----------EDDVFDDSICPTN 1423
Cdd:pfam02463  651 GVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQRekeelkklklEAEELLADRVQEA 730

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1424 CDVSLFELALQLREKRLDIEEAL--VEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNELLVVIPL 1501
Cdd:pfam02463  731 QDKINEELKLLKQKIDEEEEEEEksRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEEL 810

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1502 KLHQIEYMEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKEcRERRKLLIREKREMAKTISKMEETVREL 1581
Cdd:pfam02463  811 KEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEE-EITKEELLQELLLKEEELEEQKLKDELE 889

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1582 MISKFGRVIDLEALQTLSVNTTLEELKIKKLRKELSNAKELRMWEEKIAQ---VRWDLMMKTKEHTKKLHQMNDLCLEKK 1658
Cdd:pfam02463  890 SKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEElllEEADEKEKEENNKEEEEERNKRLLLAK 969

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|
gi 568994982  1659 KLDSRLNTLQnqqgnAFQGLRKaDIVAKQKVTELVQTQLEKITALKEEIE 1708
Cdd:pfam02463  970 EELGKVNLMA-----IEEFEEK-EERYNKDELEKERLEEEKKKLIRAIIE 1013
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1295-1495 1.74e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1295 LKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQ---EKALYAGFQAALGE-------NNKFANF 1364
Cdd:COG3883    25 LSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaeAEAEIEERREELGEraralyrSGGSVSY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1365 LMKVLKkkikrakkkevegdadedeeseesseeesslesdedaSGSEDDVFDDsicptncdvslFELALQLREKRLDIEE 1444
Cdd:COG3883   105 LDVLLG-------------------------------------SESFSDFLDR-----------LSALSKIADADADLLE 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568994982 1445 ALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNEL 1495
Cdd:COG3883   137 ELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL 187
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 786-1021 3.52e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   786 ESEAAPE-DIEDPKAYSIENARKKREHDKLMKKVEeLKAHKREQIKILRNEFWKLLELNKELpAHMQFQRTDFNidAKIH 864
Cdd:pfam17380  320 EAEKARQaEMDRQAAIYAEQERMAMERERELERIR-QEERKRELERIRQEEIAMEISRMREL-ERLQMERQQKN--ERVR 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   865 AEIHKKTSLKIEQVEKELAWEKQKHEL-GLKKLQDRFREplesDTIVVYATQSDHQIASYRLVKPSKYSKLKRPSQSE-- 941
Cdd:pfam17380  396 QELEAARKVKILEEERQRKIQQQKVEMeQIRAEQEEARQ----REVRRLEEERAREMERVRLEEQERQQQVERLRQQEee 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   942 RRQSKMErLEKEGPGKKESQRdtggsislQEESVLEKGKKFRPRTLSE-----IMVENQIEKTKKLIQQAERAQFKILQR 1016
Cdd:pfam17380  472 RKRKKLE-LEKEKRDRKRAEE--------QRRKILEKELEERKQAMIEeerkrKLLEKEMEERQKAIYEEERRREAEEER 542


                   ....*
gi 568994982  1017 KKEWE 1021
Cdd:pfam17380  543 RKQQE 547
PTZ00121 PTZ00121
MAEBL; Provisional
 803-1107 7.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  803 ENARKKREHDKLMKKVEELK-----AHKREQIKILRNEFWKLLELNK--ELPAHMQFQRTDfniDAKIHAEIHKKTSL-K 874
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKAEEAKkkadeAKKAAEAKKKADEAKKAEEAKKadEAKKAEEAKKAD---EAKKAEEKKKADELkK 1553

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  875 IEQVEKelAWEKQKHELGLKKLQDRFREPLESDTIvvyatqsdHQIASYRLVKPSK-YSKLKRPSQSERRQSKMERLEKE 953
Cdd:PTZ00121 1554 AEELKK--AEEKKKAEEAKKAEEDKNMALRKAEEA--------KKAEEARIEEVMKlYEEEKKMKAEEAKKAEEAKIKAE 1623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  954 GPGKKESQRDTGGSISLQEESVLEKGKKFR-PRTLSEIMVENQIEKTKKLIQQAERAQFKILQRKKEWEELYKSKpdddy 1032
Cdd:PTZ00121 1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA----- 1698

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1033 EDPKDVQAIKEAQTYmgdfNLKTAPDYKIPEHMR---INAAKKEEE------------LGYLDTMAHGKKRYMNKCiLSL 1097
Cdd:PTZ00121 1699 EEAKKAEELKKKEAE----EKKKAEELKKAEEENkikAEEAKKEAEedkkkaeeakkdEEEKKKIAHLKKEEEKKA-EEI 1773

                         330
                  ....*....|
gi 568994982 1098 RDLKLAVIEE 1107
Cdd:PTZ00121 1774 RKEKEAVIEE 1783
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 684-764 1.19e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  684 NPIRNITFSNDQTMMFCGMTNGAIRVYVLSENDPFLVSLQHYwhfnvhdnnyGSIKSITSSFDDQYLLTAGEDGNIFVFD 763
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT----------GPVRDVAASADGTYLASGSSDKTIRLWD 79


                  .
gi 568994982  764 I 764
Cdd:cd00200    80 L 80
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1428-1632 1.36e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 42.74  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1428 LFELALQLREKR--LDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQ---REKQQRLNELLvviplk 1502
Cdd:cd22656    96 ILELIDDLADATddEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQtalETLEKALKDLL------ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1503 lhqieymefgevpEDLSGTLVfsNHSLDRLQERIVQLQEENAKqqKLNKECRERRKLLIREKREMAK------TISKMEE 1576
Cdd:cd22656   170 -------------TDEGGAIA--RKEIKDLQKELEKLNEEYAA--KLKAKIDELKALIADDEAKLAAalrliaDLTAADT 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568994982 1577 TVRELmISKFGRVID-LEALQTL--SVNTTLEELKiKKLRKELSNAKELRMWEEKIAQV 1632
Cdd:cd22656   233 DLDNL-LALIGPAIPaLEKLQGAwqAIATDLDSLK-DLLEDDISKIPAAILAKLELEKA 289
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1427-1636 1.64e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1427 SLFELALQLRE-----KRLDIEEaLVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEE------ALEAYQREKQQRLNEL 1495
Cdd:PRK03918  497 KLKELAEQLKEleeklKKYNLEE-LEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEElkkklaELEKKLDELEEELAEL 575

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1496 LvviplklHQIEYMEFGEVPEDLSG------------TLVFSNHSLDRLQERIVQLQEE----NAKQQKLNKECRERRKL 1559
Cdd:PRK03918  576 L-------KELEELGFESVEELEERlkelepfyneylELKDAEKELEREEKELKKLEEEldkaFEELAETEKRLEELRKE 648

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1560 LirekREMAKTISKME-ETVRELMISKFGRVIDLEAlQTLSVNTTLEELK--IKKLRKELSNAKELRMWEEKIAQVRWDL 1636
Cdd:PRK03918  649 L----EELEKKYSEEEyEELREEYLELSRELAGLRA-ELEELEKRREEIKktLEKLKEELEEREKAKKELEKLEKALERV 723
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
113-484 2.10e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 2.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  113 VDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAftfTGlKLQGS 192
Cdd:COG2319    84 VAFSPDGRLLASAS--ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TG-KLLRT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  193 LgrfgKTSTSDIEGYAELPDGKVL-SGSEWGNLLLWE---GSLIKVelcRTGmkscHSGSINQIML--DEGEVITAGSDG 266
Cdd:COG2319   158 L----TGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDlatGKLLRT---LTG----HTGAVRSVAFspDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  267 SVRIWDFETIDTADVIDDTGlleiEPINelhidkSVNlFSmikmnevGNNFWLA---QDANGAIWKLDlsfsniTQDPEC 343
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHS----GSVR------SVA-FS-------PDGRLLAsgsADGTVRLWDLA------TGELLR 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  344 LFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKfkqGGTSLIWaprSVSVSA--SQIVVGFQDGVVRV 421
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVR---SVAFSPdgKTLASGSDDGTVRL 356

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994982  422 LELFDPKGLTVYAGrkkipdaelhlkyvfkpHTDEVTALAYERDGDILATGSEDKTVFFFDVE 484
Cdd:COG2319   357 WDLATGELLRTLTG-----------------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
130-506 3.59e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 3.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  130 DYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAftftglklQGSLGRFGKTSTSDIEGYAE 209
Cdd:COG2319    57 DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA--------TGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  210 LPDGK-VLSGSEWGNLLLWE---GSLIKVelcrtgmKSCHSGSINQIML--DEGEVITAGSDGSVRIWDFETIDTADVID 283
Cdd:COG2319   129 SPDGKtLASGSADGTVRLWDlatGKLLRT-------LTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  284 DTGlleiEPINELHidksvnlFSmikmnevGNNFWLA---QDANGAIWKLDlsfsniTQDPECLFSFHSGPIAALAVSPL 360
Cdd:COG2319   202 GHT----GAVRSVA-------FS-------PDGKLLAsgsADGTVRLWDLA------TGKLLRTLTGHSGSVRSVAFSPD 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  361 TYLMATTAMDCSVRVYDFSSKNPLvhmKFKQGGTSLIWaprSVSVSA--SQIVVGFQDGVVRVLELfdpkgltvyagrkk 438
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVN---SVAFSPdgKLLASGSDDGTVRLWDL-------------- 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568994982  439 ipdAELHLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSP 506
Cdd:COG2319   318 ---ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 211-506 1.24e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  211 PDGKVL-SGSEWGNLLLWEGSLIKVELCRTGmkscHSGSINQIML--DEGEVITAGSDGSVRIWDFETIDTADVIddTGl 287
Cdd:cd00200    19 PDGKLLaTGSGDGTIKVWDLETGELLRTLKG----HTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTL--TG- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  288 lEIEPINELHIDKsvnlfsmikmnevgNNFWLA---QDANGAIWKLDlsfsnitqDPECLFSF--HSGPIAALAVSPLTY 362
Cdd:cd00200    92 -HTSYVSSVAFSP--------------DGRILSsssRDKTIKVWDVE--------TGKCLTTLrgHTDWVNSVAFSPDGT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  363 LMATTAMDCSVRVYDFSSKNPL-VHMKFKQGGTSLIWAPRSvsvsaSQIVVGFQDGVVRVLELfdpkgltvyagrkkipd 441
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVaTLTGHTGEVNSVAFSPDG-----EKLLSSSSDGTIKLWDL----------------- 206

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994982  442 AELHLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSP 506
Cdd:cd00200   207 STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 113-482 4.68e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 4.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  113 VDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFW-----EMAFTFTGl 187
Cdd:cd00200    15 VAFSPDGKLLATGS--GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdletgECVRTLTG- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  188 klqgslgrfgktSTSDIEGYAELPDGKVLSGSEW-GNLLLWEgsLIKVELCRTGmkSCHSGSINQI-MLDEGEVITAGS- 264
Cdd:cd00200    92 ------------HTSYVSSVAFSPDGRILSSSSRdKTIKVWD--VETGKCLTTL--RGHTDWVNSVaFSPDGTFVASSSq 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  265 DGSVRIWDFETIdtadviddtglleiepinelhidksvnlfsmikmnevgnnfwlaqdangaiwkldlsfsnitqdpECL 344
Cdd:cd00200   156 DGTIKLWDLRTG-----------------------------------------------------------------KCV 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  345 --FSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKFKQGG-TSLIWAP-RSVSVSASQivvgfqDGVVR 420
Cdd:cd00200   171 atLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGvNSVAFSPdGYLLASGSE------DGTIR 244

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568994982  421 VlelFDpkgltVYAGRkkipdaelhLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFD 482
Cdd:cd00200   245 V---WD-----LRTGE---------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
130-506 1.59e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  130 DYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQLTTSGSGHIKFWEMAftftglklQGSLGRFGKTSTSDIEGYAE 209
Cdd:COG2319    15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA--------AGALLATLLGHTAAVLSVAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  210 LPDGKVL-SGSEWGNLLLWEGSLIKVELCRTGmkscHSGSINQIML--DEGEVITAGSDGSVRIWDfetidtadviddtg 286
Cdd:COG2319    87 SPDGRLLaSASADGTVRLWDLATGLLLRTLTG----HTGAVRSVAFspDGKTLASGSADGTVRLWD-------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  287 lleiepinelhidksvnlfsmikmnevgnnfwlaqdangaiwkldlsfsniTQDPECLFSF--HSGPIAALAVSPLTYLM 364
Cdd:COG2319   149 ---------------------------------------------------LATGKLLRTLtgHSGAVTSVAFSPDGKLL 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  365 ATTAMDCSVRVYDFSSKNPLVHMKfkqGGTSLIWaprSVSVSA--SQIVVGFQDGVVRVLELFDPKGLTVYAGrkkipda 442
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLT---GHTGAVR---SVAFSPdgKLLASGSADGTVRLWDLATGKLLRTLTG------- 244

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994982  443 elhlkyvfkpHTDEVTALAYERDGDILATGSEDKTVFFFDVEkEYKPIGFFNTP-GPICQLMWSP 506
Cdd:COG2319   245 ----------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHsGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-377 6.06e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 6.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   28 LQLLDSNTLLYVAG--NQMVLLDFKDKTQIYLQSSSGQGIGAIGVHPKKTYFAVAekGSFPKIIIYEYPSLKPYRILRdG 105
Cdd:cd00200    15 VAFSPDGKLLATGSgdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG--SSDKTIRLWDLETGECVRTLT-G 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  106 AEKAYAYVDFNNEGNLLasVGCHPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNdeQLTTSGS--GHIKFWEMAft 183
Cdd:cd00200    92 HTSYVSSVAFSPDGRIL--SSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG--TFVASSSqdGTIKLWDLR-- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  184 ftglklQGSLGRFGKTSTSDIEGYAELPDG-KVLSGSEWGNLLLWEgslikvelCRTGMKSC----HSGSINQIMLDE-G 257
Cdd:cd00200   166 ------TGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWD--------LSTGKCLGtlrgHENGVNSVAFSPdG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  258 EVITAGS-DGSVRIWDFETidtadviddtglleiepinelhidksvnlfsmikmnevgnnfwlaqdangaiwkldlsfsn 336
Cdd:cd00200   232 YLLASGSeDGTIRVWDLRT------------------------------------------------------------- 250

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568994982  337 itqdPECLFSF--HSGPIAALAVSPLTYLMATTAMDCSVRVYD 377
Cdd:cd00200   251 ----GECVQTLsgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
32-275 8.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 8.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   32 DSNTLLYVAGNQMV-LLDFKDKTQIYLQSSSGQGIGAIGVHPKKTYFAVAekGSFPKIIIYEYPSLKPYRILRDGAEKAY 110
Cdd:COG2319   131 DGKTLASGSADGTVrLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  111 AyVDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNdEQL-TTSGSGHIKFWEMAFTFTGLKL 189
Cdd:COG2319   209 S-VAFSPDGKLLASGS--ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLaSGSADGTVRLWDLATGELLRTL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  190 QGSLGRFGKTSTSdiegyaelPDGKVL-SGSEWGNLLLWEGSLIKVELCRTGmkscHSGSINQIML--DEGEVITAGSDG 266
Cdd:COG2319   285 TGHSGGVNSVAFS--------PDGKLLaSGSDDGTVRLWDLATGKLLRTLTG----HTGAVRSVAFspDGKTLASGSDDG 352


                  ....*....
gi 568994982  267 SVRIWDFET 275
Cdd:COG2319   353 TVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
32-275 7.75e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 7.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   32 DSNTLLYVAGNQMVLL-DFKDKTQIYLQSSSGQGIGAIGVHPKKTYFAVaekGSFPK-IIIYEYPSLKPYRILRDGAEKA 109
Cdd:COG2319   173 DGKLLASGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS---GSADGtVRLWDLATGKLLRTLTGHSGSV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  110 YAyVDFNNEGNLLASVGchPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDnDEQL-TTSGSGHIKFWEMAftfTGLK 188
Cdd:COG2319   250 RS-VAFSPDGRLLASGS--ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLaSGSDDGTVRLWDLA---TGKL 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  189 LQGSLGrfgktSTSDIEGYAELPDGKVL-SGSEWGNLLLWEGSLIKVELCRTGmkscHSGSINQIML--DEGEVITAGSD 265
Cdd:COG2319   323 LRTLTG-----HTGAVRSVAFSPDGKTLaSGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFspDGRTLASGSAD 393

                         250
                  ....*....|
gi 568994982  266 GSVRIWDFET 275
Cdd:COG2319   394 GTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-506 8.20e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 8.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  348 HSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLvhmKFKQGGTSLIWAPRSVSVSaSQIVVGFQDGVVRVLELFDP 427
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---RTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  428 KGLTVYAGrkkipdaelhlkyvfkpHTDEVTALAYERDGDILATGSEDKTVFFFDVEKeYKPIGFFNT-PGPICQLMWSP 506
Cdd:cd00200    84 ECVRTLTG-----------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGhTDWVNSVAFSP 145
WD40 COG2319
WD40 repeat [General function prediction only];
318-484 4.11e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 4.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  318 WLAQDANGAIWKLDLSFSNITQDPECLFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMkfkQGGTSLI 397
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---LGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  398 WApRSVSVSASQIVVGFQDGVVRVLELFDPKGLTVYAGrkkipdaelhlkyvfkpHTDEVTALAYERDGDILATGSEDKT 477
Cdd:COG2319    82 LS-VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG-----------------HTGAVRSVAFSPDGKTLASGSADGT 143


                  ....*..
gi 568994982  478 VFFFDVE 484
Cdd:COG2319   144 VRLWDLA 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 445-482 1.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568994982    445 HLKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFD 482
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
446-482 2.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 2.77e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568994982   446 LKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFD 482
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1437-1705 6.11e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.22  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1437 EKRLDIEEALVEEKKI-VDNLKKE------YDTISKK-----VKVVATNLNAAEEALEAYQRE------KQQRLNELLVV 1498
Cdd:TIGR02169  183 EENIERLDLIIDEKRQqLERLRRErekaerYQALLKEkreyeGYELLKEKEALERQKEAIERQlasleeELEKLTEEISE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1499 IPLKLHQIEymefgEVPEDLsgtlvfsNHSLDRL-QERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEET 1577
Cdd:TIGR02169  263 LEKRLEEIE-----QLLEEL-------NKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1578 VRELM--ISKFGRVIDLEALQTLSVNTTLEELKIK--KLRKEL-SNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMND 1652
Cdd:TIGR02169  331 IDKLLaeIEELEREIEEERKRRDKLTEEYAELKEEleDLRAELeEVDKEFAETRDELKDYREKLEKLKREINELKRELDR 410

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568994982  1653 LCLEKKKLDSRLNTLqnqqgnafqglrKADI-VAKQKVTELVQTQLEKITALKE 1705
Cdd:TIGR02169  411 LQEELQRLSEELADL------------NAAIaGIEAKINELEEEKEDKALEIKK 452
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1430-1708 6.39e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 6.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1430 ELALQLREKRLDIEEA--------LVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREK----------QQR 1491
Cdd:TIGR02168  210 EKAERYKELKAELRELelallvlrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVseleeeieelQKE 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1492 LNELLVVIPLKLHQIEymEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTI 1571
Cdd:TIGR02168  290 LYALANEISRLEQQKQ--ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAEL 367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1572 SKMEETVRELMiskfgrvidlEALQTLSVNTTLEELKIKKLRKELSNAK-ELRMWE---EKIAQVRWDLMMKTKEHTKKL 1647
Cdd:TIGR02168  368 EELESRLEELE----------EQLETLRSKVAQLELQIASLNNEIERLEaRLERLEdrrERLQQEIEELLKKLEEAELKE 437

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994982  1648 HQMN--DLCLEKKKLDSRLNTLQNQQGNAFQGLRKA--DIVAKQKVTELVQTQLEKITALKEEIE 1708
Cdd:TIGR02168  438 LQAEleELEEELEELQEELERLEEALEELREELEEAeqALDAAERELAQLQARLDSLERLQENLE 502
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1434-1621 1.24e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.76  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1434 QLREKRLDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEayqrEKQQRLNELLVVIpLKLHQIEYMEF-- 1511
Cdd:COG4942    52 ALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE----AQKEELAELLRAL-YRLGRQPPLALll 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1512 -GEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETV--RELMISKFGR 1588
Cdd:COG4942   127 sPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKaeRQKLLARLEK 206

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568994982 1589 VIDLEA--LQTLSVNTTLEELKIKKLRKELSNAKE 1621
Cdd:COG4942   207 ELAELAaeLAELQQEAEELEALIARLEAEAAAAAE 241
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 794-1708 1.46e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.97  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   794 IEDPKAYSIENARKKREHDKLMKKVEELKAHKREQIKILRNEFwKLLELNKELPAHMQFQRTDFNIDAKIHAEIHKKTSL 873
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQEL-KLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   874 KIEQVEKELAWEKQKHELGLKKLQDRFREPLEsdtivvyatQSDHQIASYRLVKPSKYSKLKRpSQSERRQSKMERLEKE 953
Cdd:pfam02463  237 ERIDLLQELLRDEQEEIESSKQEIEKEEEKLA---------QVLKENKEEEKEKKLQEEELKL-LAKEEEELKSELLKLE 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   954 GPGKKESQRDTGGSISLQEESVLEKGKKfrprtlsEIMVENQIEKTKKLIQQAERAQfKILQRKKEWEELYKSKPDDDYE 1033
Cdd:pfam02463  307 RRKVDDEEKLKESEKEKKKAEKELKKEK-------EEIEELEKELKELEIKREAEEE-EEEELEKLQEKLEQLEEELLAK 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1034 DPKDVQAIKEAQtymGDFNLKTAPDYKIpehmrINAAKKEEELgyldtmaHGKKRYMNKCILSLRDLKLAVIEEIQCLVQ 1113
Cdd:pfam02463  379 KKLESERLSSAA---KLKEEELELKSEE-----EKEAQLLLEL-------ARQLEDLLKEEKKEELEILEEEEESIELKQ 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1114 ELKNIQSsipaskhmpipqvpqiypeevperrfqyDEETLLRFQRKQKKRQDKSSSKQSGTGSGGSAGGGLVGFLKLSSG 1193
Cdd:pfam02463  444 GKLTEEK----------------------------EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKL 495

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1194 KEGDLTTRDSLSRSSKASALLELPKPVEFEKAEPSDAELEimkrdEVKHLYMQQFLCNRINELTVTFDAELHLLRHQKLK 1273
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLG-----VAVENYKVAISTAVIVEVSATADEVEERQKLVRAL 570

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1274 LDTKMKLSDLHHLTLFQEMLLLKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQEKALYAGFQA 1353
Cdd:pfam02463  571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRK 650

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1354 ALGENNKFANFLMKVLKKKIKRAKKKEVEGDADEDEESEESSEEESSLESDEDASGS----------EDDVFDDSICPTN 1423
Cdd:pfam02463  651 GVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQRekeelkklklEAEELLADRVQEA 730

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1424 CDVSLFELALQLREKRLDIEEAL--VEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNELLVVIPL 1501
Cdd:pfam02463  731 QDKINEELKLLKQKIDEEEEEEEksRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEEL 810

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1502 KLHQIEYMEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKEcRERRKLLIREKREMAKTISKMEETVREL 1581
Cdd:pfam02463  811 KEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEE-EITKEELLQELLLKEEELEEQKLKDELE 889

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1582 MISKFGRVIDLEALQTLSVNTTLEELKIKKLRKELSNAKELRMWEEKIAQ---VRWDLMMKTKEHTKKLHQMNDLCLEKK 1658
Cdd:pfam02463  890 SKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEElllEEADEKEKEENNKEEEEERNKRLLLAK 969

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|
gi 568994982  1659 KLDSRLNTLQnqqgnAFQGLRKaDIVAKQKVTELVQTQLEKITALKEEIE 1708
Cdd:pfam02463  970 EELGKVNLMA-----IEEFEEK-EERYNKDELEKERLEEEKKKLIRAIIE 1013
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1431-1708 1.54e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1431 LALQLREKRLDIEEALVEEKKI---VDNLKKEYDTISKKVKVVATNLNAAEEALEAyQREKQQRLNELLvviplKLHQIE 1507
Cdd:COG1196   216 RELKEELKELEAELLLLKLRELeaeLEELEAELEELEAELEELEAELAELEAELEE-LRLELEELELEL-----EEAQAE 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1508 YMEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETVRELMISKFG 1587
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1588 RVIDLEALQTLSVNTTLEEL-KIKKLRKELSNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMNDLCLEKKKLDSRLNT 1666
Cdd:COG1196   370 AEAELAEAEEELEELAEELLeALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568994982 1667 LQNQQGNAFQGLRKAdIVAKQKVTELVQTQLEKITALKEEIE 1708
Cdd:COG1196   450 EEAELEEEEEALLEL-LAELLEEAALLEAALAELLEELAEAA 490
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 446-509 1.57e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 1.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568994982  446 LKYVFKPHTDEVTALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSPASH 509
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT 64
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1295-1495 1.74e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1295 LKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEEKKNEITKLQDQ---EKALYAGFQAALGE-------NNKFANF 1364
Cdd:COG3883    25 LSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaeAEAEIEERREELGEraralyrSGGSVSY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1365 LMKVLKkkikrakkkevegdadedeeseesseeesslesdedaSGSEDDVFDDsicptncdvslFELALQLREKRLDIEE 1444
Cdd:COG3883   105 LDVLLG-------------------------------------SESFSDFLDR-----------LSALSKIADADADLLE 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568994982 1445 ALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNEL 1495
Cdd:COG3883   137 ELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQL 187
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 786-1021 3.52e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   786 ESEAAPE-DIEDPKAYSIENARKKREHDKLMKKVEeLKAHKREQIKILRNEFWKLLELNKELpAHMQFQRTDFNidAKIH 864
Cdd:pfam17380  320 EAEKARQaEMDRQAAIYAEQERMAMERERELERIR-QEERKRELERIRQEEIAMEISRMREL-ERLQMERQQKN--ERVR 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   865 AEIHKKTSLKIEQVEKELAWEKQKHEL-GLKKLQDRFREplesDTIVVYATQSDHQIASYRLVKPSKYSKLKRPSQSE-- 941
Cdd:pfam17380  396 QELEAARKVKILEEERQRKIQQQKVEMeQIRAEQEEARQ----REVRRLEEERAREMERVRLEEQERQQQVERLRQQEee 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982   942 RRQSKMErLEKEGPGKKESQRdtggsislQEESVLEKGKKFRPRTLSE-----IMVENQIEKTKKLIQQAERAQFKILQR 1016
Cdd:pfam17380  472 RKRKKLE-LEKEKRDRKRAEE--------QRRKILEKELEERKQAMIEeerkrKLLEKEMEERQKAIYEEERRREAEEER 542


                   ....*
gi 568994982  1017 KKEWE 1021
Cdd:pfam17380  543 RKQQE 547
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1434-1633 5.10e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 5.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1434 QLREKRLDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQRE---KQQRLNELLVVIPLKLHQIEYME 1510
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEaanLRERLESLERRIAATERRLEDLE 844

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1511 fgEVPEDLSGTLVFSNHSL-------DRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETVRELM- 1582
Cdd:TIGR02168  845 --EQIEELSEDIESLAAEIeeleeliEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELRe 922

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1583 -ISKFGRVID------LEALQTLSV--NTTLEELKIKKLRKELSNAKelrmWEEKIAQVR 1633
Cdd:TIGR02168  923 kLAQLELRLEglevriDNLQERLSEeySLTLEEAEALENKIEDDEEE----ARRRLKRLE 978
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1427-1708 6.33e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1427 SLFELALQLREKRLDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAyQREKQQRLNELLVVIPLKLHQI 1506
Cdd:COG4372    14 SLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQ-ARSELEQLEEELEELNEQLQAA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1507 EymefgEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKREMAKTISKMEETVRELMISKF 1586
Cdd:COG4372    93 Q-----AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1587 GRVIDLEALQTLSVNTTLEEL-------KIKKLRKELSNAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMNDLCLEKKK 1659
Cdd:COG4372   168 ALEQELQALSEAEAEQALDELlkeanrnAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEED 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568994982 1660 LDSRLNTLQNQQGNAFQGLRKADIVAKQKVTELVQTQLEKITALKEEIE 1708
Cdd:COG4372   248 KEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELK 296
PTZ00121 PTZ00121
MAEBL; Provisional
 803-1107 7.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  803 ENARKKREHDKLMKKVEELK-----AHKREQIKILRNEFWKLLELNK--ELPAHMQFQRTDfniDAKIHAEIHKKTSL-K 874
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKAEEAKkkadeAKKAAEAKKKADEAKKAEEAKKadEAKKAEEAKKAD---EAKKAEEKKKADELkK 1553

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  875 IEQVEKelAWEKQKHELGLKKLQDRFREPLESDTIvvyatqsdHQIASYRLVKPSK-YSKLKRPSQSERRQSKMERLEKE 953
Cdd:PTZ00121 1554 AEELKK--AEEKKKAEEAKKAEEDKNMALRKAEEA--------KKAEEARIEEVMKlYEEEKKMKAEEAKKAEEAKIKAE 1623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  954 GPGKKESQRDTGGSISLQEESVLEKGKKFR-PRTLSEIMVENQIEKTKKLIQQAERAQFKILQRKKEWEELYKSKpdddy 1032
Cdd:PTZ00121 1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA----- 1698

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1033 EDPKDVQAIKEAQTYmgdfNLKTAPDYKIPEHMR---INAAKKEEE------------LGYLDTMAHGKKRYMNKCiLSL 1097
Cdd:PTZ00121 1699 EEAKKAEELKKKEAE----EKKKAEELKKAEEENkikAEEAKKEAEedkkkaeeakkdEEEKKKIAHLKKEEEKKA-EEI 1773

                         330
                  ....*....|
gi 568994982 1098 RDLKLAVIEE 1107
Cdd:PTZ00121 1774 RKEKEAVIEE 1783
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 684-764 1.19e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  684 NPIRNITFSNDQTMMFCGMTNGAIRVYVLSENDPFLVSLQHYwhfnvhdnnyGSIKSITSSFDDQYLLTAGEDGNIFVFD 763
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT----------GPVRDVAASADGTYLASGSSDKTIRLWD 79


                  .
gi 568994982  764 I 764
Cdd:cd00200    80 L 80
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1428-1632 1.36e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 42.74  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1428 LFELALQLREKR--LDIEEALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQ---REKQQRLNELLvviplk 1502
Cdd:cd22656    96 ILELIDDLADATddEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQtalETLEKALKDLL------ 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1503 lhqieymefgevpEDLSGTLVfsNHSLDRLQERIVQLQEENAKqqKLNKECRERRKLLIREKREMAK------TISKMEE 1576
Cdd:cd22656   170 -------------TDEGGAIA--RKEIKDLQKELEKLNEEYAA--KLKAKIDELKALIADDEAKLAAalrliaDLTAADT 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568994982 1577 TVRELmISKFGRVID-LEALQTL--SVNTTLEELKiKKLRKELSNAKELRMWEEKIAQV 1632
Cdd:cd22656   233 DLDNL-LALIGPAIPaLEKLQGAwqAIATDLDSLK-DLLEDDISKIPAAILAKLELEKA 289
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1427-1636 1.64e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1427 SLFELALQLRE-----KRLDIEEaLVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEE------ALEAYQREKQQRLNEL 1495
Cdd:PRK03918  497 KLKELAEQLKEleeklKKYNLEE-LEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEElkkklaELEKKLDELEEELAEL 575

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1496 LvviplklHQIEYMEFGEVPEDLSG------------TLVFSNHSLDRLQERIVQLQEE----NAKQQKLNKECRERRKL 1559
Cdd:PRK03918  576 L-------KELEELGFESVEELEERlkelepfyneylELKDAEKELEREEKELKKLEEEldkaFEELAETEKRLEELRKE 648

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1560 LirekREMAKTISKME-ETVRELMISKFGRVIDLEAlQTLSVNTTLEELK--IKKLRKELSNAKELRMWEEKIAQVRWDL 1636
Cdd:PRK03918  649 L----EELEKKYSEEEyEELREEYLELSRELAGLRA-ELEELEKRREEIKktLEKLKEELEEREKAKKELEKLEKALERV 723
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1430-1674 1.85e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1430 ELALQLREKRLDIEEALVEEKKIVDNLKKEYDTISKKV----------KVVATNLNAAEEALEAYQREKQQRLNELlvvi 1499
Cdd:PRK02224  488 EEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIaerretieekRERAEELRERAAELEAEAEEKREAAAEA---- 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1500 plklhQIEYMEFGEVPEDLSGTLVFSNHSLDRLqERIVQLQEENAkqqklnkECRERRKLLiREKREmakTISKMEETVR 1579
Cdd:PRK02224  564 -----EEEAEEAREEVAELNSKLAELKERIESL-ERIRTLLAAIA-------DAEDEIERL-REKRE---ALAELNDERR 626

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1580 ELMISKFGRVIDLEAlqtlsvntTLEELKIKKLRKELSNAKE-LRMWEEKIAQV---RWDLMMKTKEHTKKLHQMNDLCL 1655
Cdd:PRK02224  627 ERLAEKRERKRELEA--------EFDEARIEEAREDKERAEEyLEQVEEKLDELreeRDDLQAEIGAVENELEELEELRE 698

                         250
                  ....*....|....*....
gi 568994982 1656 EKKKLDSRLNTLQNQQGNA 1674
Cdd:PRK02224  699 RREALENRVEALEALYDEA 717
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1295-1581 2.37e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1295 LKNFEKQENILQERVNSLDKEEQDMQWKINETLKEMEE---KKNEITKLQDQEKALYAGFQAALGENNKFANFLMKVLKK 1371
Cdd:TIGR02168  735 LARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEaeeELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTL 814

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1372 KIKRAKKKEVEGDADEDEESEESSEEESSLESDEDASGSEDDVfddsicptncDVSLFELALQLREKRLDIEEALVEEKK 1451
Cdd:TIGR02168  815 LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL----------AAEIEELEELIEELESELEALLNERAS 884

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  1452 I---VDNLKKEYDTISKKVKVVATNLNAAE-------EALEAYQREKQ---QRLNELLVVIPlKLHQIEYMEFGEVPEDL 1518
Cdd:TIGR02168  885 LeeaLALLRSELEELSEELRELESKRSELRreleelrEKLAQLELRLEgleVRIDNLQERLS-EEYSLTLEEAEALENKI 963

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568994982  1519 SGTLVFSNHSLDRLQERIVQLQEENakqqkLN-----KECRERRKLLIREKREMAKTISKMEETVREL 1581
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIKELGPVN-----LAaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 2.40e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.40e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568994982    338 TQDPECLFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYD 377
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00121 PTZ00121
MAEBL; Provisional
 786-1045 5.42e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 5.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  786 ESEAAPEDIEDPKAYSIENARKKREHDKLmKKVEELK----AHKREQIKilRNEFWKLLELNK-ELPAHMQFQRTDFNID 860
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEEKKKADEL-KKAEELKkaeeKKKAEEAK--KAEEDKNMALRKaEEAKKAEEARIEEVMK 1599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  861 AKIHAEIHKKTSLKIEQVEKELAWEKQKHELGLKKLQDRFREPLESdtivvyaTQSDHQIASYRLVKPSKYSKLKRPSQS 940
Cdd:PTZ00121 1600 LYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEE-------KKKAEELKKAEEENKIKAAEEAKKAEE 1672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982  941 ERRQSKMERLEKEGPGKKESQRDtggsislQEESVLEKGKKFRPRTlseimvENQIEKTKKLIQQAERAQFKILQRKKEW 1020
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALK-------KEAEEAKKAEELKKKE------AEEKKKAEELKKAEEENKIKAEEAKKEA 1739

                         250       260
                  ....*....|....*....|....*...
gi 568994982 1021 EElYKSKPDD---DYEDPKDVQAIKEAQ 1045
Cdd:PTZ00121 1740 EE-DKKKAEEakkDEEEKKKIAHLKKEE 1766
WD40 pfam00400
WD domain, G-beta repeat;
342-377 6.09e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 6.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568994982   342 ECLFSF--HSGPIAALAVSPLTYLMATTAMDCSVRVYD 377
Cdd:pfam00400    2 KLLKTLegHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1506-1649 9.11e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.61  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994982 1506 IEYMEFGEVPEDLSGTLVFSNHS---LDRLQERIVQLQEENAKQQKLNKECRERrkllIREKREmakTISKMEETVRELM 1582
Cdd:COG2433   382 LEELIEKELPEEEPEAEREKEHEereLTEEEEEIRRLEEQVERLEAEVEELEAE----LEEKDE---RIERLERELSEAR 454

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568994982 1583 ISKFGRVIDLEALQTLsvNTTLEELKiKKLRKELSNAKELRmweEKIAqvrwdlmmKTKEHTKKLHQ 1649
Cdd:COG2433   455 SEERREIRKDREISRL--DREIERLE-RELEEERERIEELK---RKLE--------RLKELWKLEHS 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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