NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568994700|ref|XP_006521892|]
View 

mannan-binding lectin serine protease 1 isoform X3 [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 10806461)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to CUB domain-containing protein 2 (CDCP2)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CUB pfam00431
CUB domain;
190-299 7.08e-37

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 129.34  E-value: 7.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568994700  266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.44e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.74  E-value: 4.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568994700 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 2.01e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 2.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994700 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.07e-08
                          10        20
                  ....*....|....*....|....*....
gi 568994700  158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
CUB pfam00431
CUB domain;
190-299 7.08e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 129.34  E-value: 7.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568994700  266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 190-301 2.20e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 125.60  E-value: 2.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568994700 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.44e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.74  E-value: 4.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568994700 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-299 6.17e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.94  E-value: 6.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700   200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 568994700   275 TQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 34-140 2.13e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 109.40  E-value: 2.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700    34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568994700   110 EVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
28-140 1.21e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 88.89  E-value: 1.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700   28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568994700  104 eqtpGQEVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 2.01e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 2.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994700 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 306-367 8.82e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.07  E-value: 8.82e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568994700   306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
306-367 1.22e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568994700  306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.07e-08
                          10        20
                  ....*....|....*....|....*....
gi 568994700  158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-186 5.99e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 5.99e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568994700   144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-181 1.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.98e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568994700 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054    1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 284-369 1.97e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 39.68  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLVSCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954 108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178


                 ....*.
gi 568994700 364 IPTCKK 369
Cdd:PHA02954 179 IPSCQQ 184
 
Name Accession Description Interval E-value
CUB pfam00431
CUB domain;
190-299 7.08e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 129.34  E-value: 7.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  190 CSGNlFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:pfam00431   1 CGGV-LTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDHDE--CGYDYVEIRDGpsasSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568994700  266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 190-301 2.20e-35

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 125.60  E-value: 2.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700 190 CSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFC 265
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYDGpstsSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568994700 266 GEKSPEPISTQTHSVQILFRSDNSGENRGWRLSYRA 301
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-142 4.44e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.74  E-value: 4.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700  33 FGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGRETTdteqtpg 108
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGSTLP------- 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568994700 109 qEVVLSPGTFMSVTFRSDFSNeeRFTGFDAHYMA 142
Cdd:cd00041   83 -PPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 200-299 6.17e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.94  E-value: 6.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700   200 GTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDiFDIEDHPEvpCPYDYIKIKAG----SKVWGPFCGEKSPEP-IS 274
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN--CEYDYVEIYDGpsasSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 568994700   275 TQTHSVQILFRSDNSGENRGWRLSY 299
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 34-140 2.13e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 109.40  E-value: 2.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700    34 GQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdteqtPGQ 109
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568994700   110 EVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKR--GFSARY 102
CUB pfam00431
CUB domain;
28-140 1.21e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 88.89  E-value: 1.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700   28 ELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKV----ETEDQVLATFCGREttdt 103
Cdd:pfam00431   4 VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGSG---- 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568994700  104 eqtpGQEVVLSPGTFMSVTFRSDFSNEERftGFDAHY 140
Cdd:pfam00431  80 ----IPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 306-368 2.01e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.93  E-value: 2.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568994700 306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTCK 368
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSST------ITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 306-367 8.82e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.07  E-value: 8.82e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568994700   306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSST------ITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
306-367 1.22e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.66  E-value: 1.22e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568994700  306 CPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEvmdtfqIECLKDGAWSNKIPTC 367
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPT------ITCQEDGTWSPPFPEC 56
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 158-186 1.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 1.07e-08
                          10        20
                  ....*....|....*....|....*....
gi 568994700  158 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 186
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-186 5.99e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 5.99e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568994700   144 DVDECKEREDeelsCDH--YCHNYIGGYYCSCRFGYilhTDNRTC 186
Cdd:smart00179   1 DIDECASGNP----CQNggTCVNTVGSYRCECPPGY---TDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-181 1.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.98e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568994700 144 DVDECKEREdeelSCDHY--CHNYIGGYYCSCRFGYILHT 181
Cdd:cd00054    1 DIDECASGN----PCQNGgtCVNTVGSYRCSCPPGYTGRN 36
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 284-369 1.97e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 39.68  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994700 284 FRSDNSGENRGWRLSYRAAGNECPKLQPPvYGKIEPSQAVYSFKDQVLVSCDTGYkvlkdnEVMDTFQIECLKDgAWsNK 363
Cdd:PHA02954 108 FRCEEKNGNTSWNDTVTCPNAECQPLQLE-HGSCQPVKEKYSFGEHITINCDVGY------EVIGASYISCTAN-SW-NV 178


                 ....*.
gi 568994700 364 IPTCKK 369
Cdd:PHA02954 179 IPSCQQ 184
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 121-185 2.74e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.91  E-value: 2.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568994700 121 VTFRSDFSNEERFTGFDAHYMAVDVDECKEredEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 185
Cdd:cd01475  163 VFYVEDFSTIEELTKKFQGKICVVPDLCAT---LSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
144-176 5.35e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.14  E-value: 5.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568994700  144 DVDECkerEDEELSCDH--YCHNYIGGYYCSCRFG 176
Cdd:pfam07645   1 DVDEC---ATGTHNCPAntVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH