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Conserved domains on  [gi|568993488|ref|XP_006521533|]
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rho GTPase-activating protein 8 isoform X4 [Mus musculus]

Protein Classification

SEC14 and RhoGAP domain-containing protein( domain architecture ID 10617236)

SEC14 and RhoGAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 193-381 5.29e-95

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04404:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 195  Bit Score: 283.46  E-value: 5.29e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 271
Cdd:cd04404    6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 351
Cdd:cd04404   86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 568993488 352 WPSQGVASLSALVPLNLFTELLIEYYDKVF 381
Cdd:cd04404  166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-165 1.22e-28

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


:

Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 109.34  E-value: 1.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   32 GRRIFTFSCCRLP--PLHQLNHQRLLEYLKYTLDQHVE-NDYTIVYFHYGLSSQNKPSLGWLQNTYKEFDRKYKKNLKAL 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKgKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488  109 YVVHPTSLIK-ALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIP-PEVVRYDE 165
Cdd:pfam13716  81 YVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTElPGVLSYDE 139
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 5.29e-95

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 283.46  E-value: 5.29e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 271
Cdd:cd04404    6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 351
Cdd:cd04404   86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 568993488 352 WPSQGVASLSALVPLNLFTELLIEYYDKVF 381
Cdd:cd04404  166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 210-355 6.61e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 171.19  E-value: 6.61e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488  210 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 288
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568993488  289 LGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 355
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 209-377 5.28e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 153.96  E-value: 5.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   209 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLTFQAYEQ 287
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   288 ILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQG-VASLSALVP 365
Cdd:smart00324  83 FIEAAKLEDETeRLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 568993488   366 LNLFTELLIEYY 377
Cdd:smart00324 163 QNTVIEFLIENA 174
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-165 1.22e-28

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 109.34  E-value: 1.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   32 GRRIFTFSCCRLP--PLHQLNHQRLLEYLKYTLDQHVE-NDYTIVYFHYGLSSQNKPSLGWLQNTYKEFDRKYKKNLKAL 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKgKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488  109 YVVHPTSLIK-ALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIP-PEVVRYDE 165
Cdd:pfam13716  81 YVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTElPGVLSYDE 139
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 21-157 1.09e-26

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 104.72  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488  21 GILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLEYLKYTLDQHVENDYTIVYFHY------GLSSQNKPSLGWLQNTY 94
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVF-RAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNLSDLSLLKKLL 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568993488  95 KEFDRKYKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC-SNLRELREHLQCDQLLIP 157
Cdd:cd00170   89 KILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKE 152
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 16-165 5.46e-25

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 100.07  E-value: 5.46e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488    16 DVARHGILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLEYLKYTLDQHVEN---DYTIVYFHYGLSSQNKPS----LG 88
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIE-RAGRFDLKSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488    89 WLQNTYKEFDRKYKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNL--RELREHLQCDQLliPPEVVRYDE 165
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDskEELLEYIDKEQL--PEELGGTLD 158
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 5.29e-95

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 283.46  E-value: 5.29e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 271
Cdd:cd04404    6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 351
Cdd:cd04404   86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 568993488 352 WPSQGVASLSALVPLNLFTELLIEYYDKVF 381
Cdd:cd04404  166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 210-355 6.61e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 171.19  E-value: 6.61e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488  210 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 288
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568993488  289 LGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 355
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 210-376 1.23e-47

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 160.55  E-value: 1.23e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 210 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQIL 289
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 290 GI-TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQGVASLSALVP-LN 367
Cdd:cd00159   81 ELaKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDIKkLN 160


                 ....*....
gi 568993488 368 LFTELLIEY 376
Cdd:cd00159  161 EIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 209-377 5.28e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 153.96  E-value: 5.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   209 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLTFQAYEQ 287
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   288 ILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQG-VASLSALVP 365
Cdd:smart00324  83 FIEAAKLEDETeRLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 568993488   366 LNLFTELLIEYY 377
Cdd:smart00324 163 QNTVIEFLIENA 174
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 5.09e-39

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 139.13  E-value: 5.09e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQ-YLrdKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG--KPVNFDDYGDMHLPAVILK 269
Cdd:cd04386    5 FGTPLEeHL--KRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfSLPLDEFYSDPHAVASALK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 270 TFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGL 348
Cdd:cd04386   83 SYLRELPDPLLTYNLYEDWVQAANKPDEDeRLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAP 162

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568993488 349 NLIWP------SQGVASLSALVplNLFTELLIEYYDKVF 381
Cdd:cd04386  163 NLLWAknegslAEMAAGTSVHV--VAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-391 4.34e-32

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 120.48  E-value: 4.34e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQylRDKNQGELIPPVLRwTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILKTFL 272
Cdd:cd04402    2 FGQPLS--NICEDDNLPKPILD-MLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 273 RELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 351
Cdd:cd04402   78 RNIPGSLLSSDLYEEWMSALDQENEEeKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 568993488 352 WPSQG----VASLSALVPLnlfTELLIEYydkvfsCQEAPGEHT 391
Cdd:cd04402  158 WPPASselqNEDLKKVTSL---VQFLIEN------CQEIFGEDI 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-375 3.21e-31

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 117.95  E-value: 3.21e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQ-GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 271
Cdd:cd04393    3 FGVPLQELQQAGQpENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLT-------FQAYEQILGITSVESSLrvthcRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 344
Cdd:cd04393   83 LQELPEGLIPaslqirlMQLYQDYNGEDEFGRKL-----RDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAA 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568993488 345 VFGLNLIWPSQGVASLSALVPLNLFTELLIE 375
Cdd:cd04393  158 VFGPDVFHVYTDVEDMKEQEICSRIMAKLLE 188
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 32-165 1.22e-28

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 109.34  E-value: 1.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   32 GRRIFTFSCCRLP--PLHQLNHQRLLEYLKYTLDQHVE-NDYTIVYFHYGLSSQNKPSLGWLQNTYKEFDRKYKKNLKAL 108
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKgKPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488  109 YVVHPTSLIK-ALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIP-PEVVRYDE 165
Cdd:pfam13716  81 YVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTElPGVLSYDE 139
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 208-353 3.23e-28

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 110.23  E-value: 3.23e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 208 LIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQ 287
Cdd:cd04390   21 LVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488 288 ILGITSVESSLRVT-HCRLI--LRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWP 353
Cdd:cd04390  101 FLSCAQLLSKDEEKgLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRP 169
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 21-157 1.09e-26

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 104.72  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488  21 GILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLEYLKYTLDQHVENDYTIVYFHY------GLSSQNKPSLGWLQNTY 94
Cdd:cd00170   10 GIGYLGGRDKEGRPVLVF-RAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVviidlkGFSLSNLSDLSLLKKLL 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568993488  95 KEFDRKYKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC-SNLRELREHLQCDQLLIP 157
Cdd:cd00170   89 KILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKE 152
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-347 4.26e-26

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.06  E-value: 4.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG-KPVNFDDYGdMHLPAVILKTF 271
Cdd:cd04377    1 FGVSLSSLTSEDRS--VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYP-IHVITSVLKQW 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568993488 272 LRELPQPLLTFQAYEQILGITSV-ESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 347
Cdd:cd04377   78 LRELPEPLMTFELYENFLRAMELeEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-361 4.33e-26

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 104.48  E-value: 4.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKN--QGELIPPVLRWTVTYLrEKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNfddygDMHLP---AVI 267
Cdd:cd04394    2 FGVPLHSLPHSTvpEYGNVPKFLVDACTFL-LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL-----SSALPcdvAGL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 268 LKTFLRELPQPLLTFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 346
Cdd:cd04394   76 LKQFFRELPEPLLPYDLHEALLKAQELPTdEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIF 155

                        170
                 ....*....|....*
gi 568993488 347 GLNLIWPSQGVASLS 361
Cdd:cd04394  156 APNLFQSEEGGEKMS 170
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 16-165 5.46e-25

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 100.07  E-value: 5.46e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488    16 DVARHGILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLEYLKYTLDQHVEN---DYTIVYFHYGLSSQNKPS----LG 88
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIE-RAGRFDLKSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488    89 WLQNTYKEFDRKYKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNL--RELREHLQCDQLliPPEVVRYDE 165
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDskEELLEYIDKEQL--PEELGGTLD 158
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 209-381 3.66e-24

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 98.74  E-value: 3.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 209 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ-GKPVNFDD--YGDMHLPAVILKTFLRELPQPLLTFQAY 285
Cdd:cd04372   16 RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISAtvYPDINVITGALKLYFRDLPIPVITYDTY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 286 EQILGITSV-ESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ--GVASLSA 362
Cdd:cd04372   96 PKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEdsALTTLND 175

                        170
                 ....*....|....*....
gi 568993488 363 LVPLNLFTELLIEYYDKVF 381
Cdd:cd04372  176 MRYQILIVQLLITNEDVLF 194
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 3.32e-23

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 96.32  E-value: 3.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSL--QYLRDknqGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQgKPVNFD-----DY-GDMHLP 264
Cdd:cd04398    1 FGVPLedLILRE---GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDK-DPLNVLlispeDYeSDIHSV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 265 AVILKTFLRELPQPLLTFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLA 343
Cdd:cd04398   77 ASLLKLFFRELPEPLLTKALSREFIEAAKIEDeSRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568993488 344 CVFGLNLI-WPSQGVASLSALVPLnlfTELLIEYYDKVF 381
Cdd:cd04398  157 IIWGPTLMnAAPDNAADMSFQSRV---IETLLDNAYQIF 192
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 209-351 6.86e-23

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 95.59  E-value: 6.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 209 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 288
Cdd:cd04376    9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568993488 289 LGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESIS-----------NKMNSSNLACVFGLNLI 351
Cdd:cd04376   89 IGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLL 162
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-345 6.75e-22

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 92.11  E-value: 6.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQ---GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILK 269
Cdd:cd04381    1 FGASLSLAVERSRchdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEY-EPPTVASLLK 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568993488 270 TFLRELPQPLLT---FQAYEQILGITSVESslRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 345
Cdd:cd04381   80 QYLRELPEPLLTkelMPRFEEACGRPTEAE--REQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-376 2.33e-21

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 91.33  E-value: 2.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVS-LQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKT 270
Cdd:cd04378    1 FGVDfSQVPRDFPDE--VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDlVELSELSPHDISSV-LKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 271 FLRELPQPLLTFQAYEQILGI---------------TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISN 335
Cdd:cd04378   78 FLRQLPEPLILFRLYNDFIALakeiqrdteedkapnTPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEEN 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568993488 336 KMNSSNLACVFGLNLIWPSQGVA--SLSALVPLN---LFTELLIEY 376
Cdd:cd04378  158 KMSPNNLGIVFGPTLIRPRPGDAdvSLSSLVDYGyqaRLVEFLITN 203
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 193-375 2.42e-21

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 90.91  E-value: 2.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKnQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG--DMHLPAVILKT 270
Cdd:cd04403    1 FGCHLEALCQR-ENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKweDIHVITGALKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 271 FLRELPQPLLTFQAYEQIL-GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLN 349
Cdd:cd04403   80 FFRELPEPLFPYSLFNDFVaAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                        170       180
                 ....*....|....*....|....*..
gi 568993488 350 LIWPSQGVASLSA-LVPLNLFTELLIE 375
Cdd:cd04403  160 LLRPEQETGNIAVhMVYQNQIVELILL 186
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 194-351 2.55e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 90.94  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 194 GVSLQYLRDKNQgeLIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYG-DMHLPAVILKTF 271
Cdd:cd04383    5 GSLEEYIQDSGQ--AIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdPLADDQNDhDINSVAGVLKLY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNL 350
Cdd:cd04383   83 FRGLENPLFPKERFEDLMSCVKLENPTeRVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTL 162


                 .
gi 568993488 351 I 351
Cdd:cd04383  163 M 163
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 1.27e-20

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 89.00  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFR----RSASAQTVRQVQRLYDQgkpVNFDD--YGDMHLPAV 266
Cdd:cd04395    2 FGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRvpgnNAAISALQEELNRGGFD---IDLQDprWRDVNVVSS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 267 ILKTFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 345
Cdd:cd04395   79 LLKSFFRKLPEPLFTNELYPDFIEANRIEDPVeRLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIV 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568993488 346 FGLNLIWPSQGvaSLSALVPlNL-----FTELLIEYYDKVF 381
Cdd:cd04395  159 FGPTLVRTSDD--NMETMVT-HMpdqckIVETLIQHYDWFF 196
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 193-381 1.87e-20

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 88.57  E-value: 1.87e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSL----QYLRDKNQGELIPPVLRWTVTYL-REKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNF---DDYGDMHLP 264
Cdd:cd04400    2 FGSPLeeavELSSHKYNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 265 AVILKTFLRELPQPLLTFQAYEQILGITSVESSL--RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNL 342
Cdd:cd04400   82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRsqRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568993488 343 ACVFG--LNliwpsqgvaslsalVPLNLFTELLIEyYDKVF 381
Cdd:cd04400  162 CIVFSptLN--------------IPAGIFVLFLTD-FDCIF 187
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-381 8.11e-20

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 87.40  E-value: 8.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQ----GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQR-----------LYDQGKPvnfdd 257
Cdd:cd04391    2 FGVPLSTLLERDQkkvpGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQeleakfyegtfLWDQVKQ----- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 258 ygdmHLPAVILKTFLRELPQPLLT---FQAYEQILGITSVESSLRVTHCRLILrsLPEHNYAVLRYLMGFLHEVSLESIS 334
Cdd:cd04391   77 ----HDAASLLKLFIRELPQPLLTveyLPAFYSVQGLPSKKDQLQALNLLVLL--LPEANRDTLKALLEFLQKVVDHEEK 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568993488 335 NKMNSSNLACVFGLNLiWPSQGVAS----------LSALVPLNLfTELLIEYYDKVF 381
Cdd:cd04391  151 NKMNLWNVAMIMAPNL-FPPRGKHSkdneslqeevNMAAGCANI-MRLLIRYQDLLW 205
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-346 1.86e-19

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 85.43  E-value: 1.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYL-RDKNQgelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG-KPVNFDDYgDMHLPAVILKT 270
Cdd:cd04407    1 FGVRVGSLtSNKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENY-PIHAITGLLKQ 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568993488 271 FLRELPQPLLTFQAYEQIL-GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 346
Cdd:cd04407   77 WLRELPEPLMTFAQYNDFLrAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVF 153
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 193-351 2.15e-19

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 85.52  E-value: 2.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKnQGELIPPV-LRWTVTYLREK-----GLRTEGLFRRSASAQTVRQVQRLYDQGKpVNFDDYGDMHLPAV 266
Cdd:cd04389    1 FGSSLEEIMDR-QKEKYPELkLPWILTFLSEKvlalgGFQTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVPAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 267 ILKTFLRELPQPLLTFQAYEQilgitSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESI--SNKMNSSNLAC 344
Cdd:cd04389   79 LLKLWLRELEEPLIPDALYQQ-----CISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENvaHTKMDVSNLAM 153


                 ....*..
gi 568993488 345 VFGLNLI 351
Cdd:cd04389  154 VFAPNIL 160
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-355 1.23e-17

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 80.97  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 222 EKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLT---FQAYEQILGITSVESS 297
Cdd:cd04392   21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLThahYPAHLQIADLCQFDEK 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568993488 298 LRVTHCR----------LILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 355
Cdd:cd04392  101 GNKTSAPdkerllealqLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRN 168
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-354 1.39e-17

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 80.19  E-value: 1.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLrDKNQGElIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTF 271
Cdd:cd04373    1 FGVPLANV-VTSEKP-IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALKSF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTF---QAYEQILGITSVESslRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFgl 348
Cdd:cd04373   79 FSELPDPLIPYsmhLELVEAAKINDREQ--RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICF-- 154


                 ....*.
gi 568993488 349 nliWPS 354
Cdd:cd04373  155 ---WPT 157
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 193-355 1.84e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 80.59  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGE-LIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ---GKPVNFDDYGDMHLPAVIL 268
Cdd:cd04379    1 FGVPLSRLVEREGESrDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 269 KTFLRELPQPLLTFQAYEQILGITSVESSLRVT----HCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 344
Cdd:cd04379   81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQtnthLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                        170
                 ....*....|.
gi 568993488 345 VFGLNLIWPSQ 355
Cdd:cd04379  161 CFGPVLMFCSQ 171
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 220-375 3.02e-17

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 79.74  E-value: 3.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 220 LREKGLRTEGLFRRSASAQtvrQVQRLYDQGKPVNFDDYGDMHLP---------AVILKTFLRELPQPLLTFQAYEQ-IL 289
Cdd:cd04374   39 VETRGINEQGLYRVVGVNS---KVQKLLSLGLDPKTSTPGDVDLDnseweiktiTSALKTYLRNLPEPLMTYELHNDfIN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 290 GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ-GVASLSALVPLNL 368
Cdd:cd04374  116 AAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEeTVAAIMDIKFQNI 195


                 ....*..
gi 568993488 369 FTELLIE 375
Cdd:cd04374  196 VVEILIE 202
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 203-376 4.00e-17

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 79.47  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 203 KNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKTFLRELPQPLLT 281
Cdd:cd04409   10 KKSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSPHDISNV-LKLYLRQLPEPLIL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 282 FQAYEQILGI-----------------------TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMN 338
Cdd:cd04409   89 FRLYNEFIGLakesqhvnetqeakknsdkkwpnMCTELNRILLKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKMS 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568993488 339 SSNLACVFGLNLIWPSQGVA--SLSALVPLN---LFTELLIEY 376
Cdd:cd04409  169 ASNLGIIFGPTLIRPRPTDAtvSLSSLVDYPhqaRLVELLITY 211
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-347 1.38e-16

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 77.35  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYD-QGKPVNFDDYgDMHLPAVILKTF 271
Cdd:cd04406    1 FGVELSRLTSEDRS--VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDtDANSVNLDDY-NIHVIASVFKQW 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568993488 272 LRELPQPLLTFQAYEQILGITSVESSLRVTH-CRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 347
Cdd:cd04406   78 LRDLPNPLMTFELYEEFLRAMGLQERRETVRgVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-354 7.69e-16

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 75.86  E-value: 7.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGEL----------IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQgKPVNFDDYGD-- 260
Cdd:cd04397    1 FGVPLEILVEKFGADStlgvgpgklrIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDK-NPTEVPDLSKen 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 261 -MHLpAVILKTFLRELPQPLLTFQAYEQILGITSVESSL---RVTHcrLILRSLPEHNYAVLRYLMGFLHEVSL-----E 331
Cdd:cd04397   80 pVQL-AALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEerkRVLH--LVYCLLPKYHRDTMEVLFSFLKWVSSfshidE 156

                        170       180
                 ....*....|....*....|...
gi 568993488 332 SISNKMNSSNLACVFGLNLIWPS 354
Cdd:cd04397  157 ETGSKMDIHNLATVITPNILYSK 179
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 193-355 1.46e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 74.96  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRdKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDqgkpVNFDD----YGDMHLPAV-- 266
Cdd:cd04387    1 FGVKISTVT-KRERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFD----TNNKDvsvmLSEMDVNAIag 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 267 ILKTFLRELPQPLLTFQAYEQILGITSVESSLRVTHCRL-ILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 345
Cdd:cd04387   76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLnLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATV 155

                        170
                 ....*....|
gi 568993488 346 FGLNLIWPSQ 355
Cdd:cd04387  156 FGPTLLRPSE 165
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-355 3.14e-15

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 73.69  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 204 NQGELIPPVLRWTVTYLREKGLrTEGLFRRSASAQTVRQVQRLYDQGKP---VNFDDYGDMHLPAVILKTFLRELPQPLL 280
Cdd:cd04384   13 NSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIpdlTKDVYIQDIHSVSSLCKLYFRELPNPLL 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568993488 281 TFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 355
Cdd:cd04384   92 TYQLYEKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQ 167
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 209-379 5.62e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 73.60  E-value: 5.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 209 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ----GKPVNFDDYgDMHLPAVILKTFLRELPQPLLTFQA 284
Cdd:cd04396   32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTppdyGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPLDL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 285 YEQ----ILGITSVESSLRVTHC--------------RLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 346
Cdd:cd04396  111 YEEfrnpLRKRPRILQYMKGRINeplntdidqaikeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIF 190

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568993488 347 GLNLIW-PSQGVAS----LSALVplnlfTELLIEYYDK 379
Cdd:cd04396  191 QPGILShPDHEMDPkeykLSRLV-----VEFLIEHQDK 223
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 193-346 1.44e-14

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 72.45  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNqGELIPPVLRWTVTYLREKGLRTEGLFRRS---ASAQTVRQVQRLYDqgKPVNFDDYgDMHLPAVILK 269
Cdd:cd04375    5 FGVPLLVNLQRT-GQPLPRSIQQAMRWLRNNALDQVGLFRKSgvkSRIQKLRSMIESST--DNVNYDGQ-QAYDVADMLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 270 TFLRELPQPLLTFQAYEQILGITSV---ESSLRVTHCRLILrsLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 346
Cdd:cd04375   81 QYFRDLPEPLLTNKLSETFIAIFQYvpkEQRLEAVQCAILL--LPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCL 158
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 193-364 2.01e-14

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 71.77  E-value: 2.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGELIPPVLRWTVTyLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKTF 271
Cdd:cd04408    1 FGVDFSQLPRDFPEEVPFVVVRCTAE-IENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSGHSPHDITSV-LKHF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 272 LRELPQPLLTFQAYEQILGI--------------TSVESSLrVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKM 337
Cdd:cd04408   79 LKELPEPVLPFQLYDDFIALakelqrdsekaaesPSIVENI-IRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKM 157

                        170       180
                 ....*....|....*....|....*...
gi 568993488 338 NSSNLACVFGLNLIWPSQGVA-SLSALV 364
Cdd:cd04408  158 SPNNLGIVFGPTLLRPLVGGDvSMICLL 185
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 198-347 1.28e-13

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 68.87  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 198 QYLRDKNqgelIPPVLRWTVTYLREKGLRTEGLFRRSAsaqTVRQVQRLYD--QGKPVNFD-DYGDMHLPAV--ILKTFL 272
Cdd:cd04385    8 QQLTDND----IPVIVDKCIDFITQHGLMSEGIYRKNG---KNSSVKKLLEafRKDARSVQlREGEYTVHDVadVLKRFL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568993488 273 RELPQPLLTFQAYEQILGITSVE-SSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 347
Cdd:cd04385   81 RDLPDPLLTSELHAEWIEAAELEnKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFG 156
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-351 1.62e-13

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 69.29  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGEL---IPPVLRWTVTYLREKGLRTEGLFR----RSASAQTVRQVQRLYDQGKPVNFDdyGDMHLPA 265
Cdd:cd04380   31 LIDQLELGDNPDYSEVplsIPKEIWRLVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSPFNSP--GSAESVA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 266 VILKTFLRELPQPLLTFQAYEQILgitsVESSLRVTHCRLILR-SLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 344
Cdd:cd04380  109 EALLLFLESLPDPIIPYSLYERLL----EAVANNEEDKRQVIRiSLPPVHRNVFVYLCSFLRELLSESADRGLDENTLAT 184


                 ....*..
gi 568993488 345 VFGLNLI 351
Cdd:cd04380  185 IFGRVLL 191
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 193-347 1.05e-12

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 66.55  E-value: 1.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 193 FGVSLQYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFL 272
Cdd:cd04382    1 IGTGELADFDPSTSPMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568993488 273 RELPQPLLTFQAYEQILGITSVESSLRV--THCRLIlRSLPEHNYAVLRYLMGFLHEVSlESISNKMNSSNLACVFG 347
Cdd:cd04382   81 RSLKEPLITFALWKEFMEAAEILDEDNSraALYQAI-SELPQPNRDTLAFLILHLQRVA-QSPECKMDINNLARVFG 155
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 207-347 9.89e-11

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 61.04  E-value: 9.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488 207 ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILKTFLRELPQPLLTFQAYE 286
Cdd:cd04388   13 DVAPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCDAASVDLEQF-DVAALADALKRYLLDLPNPVIPAPVYS 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568993488 287 QILGITSVESSLR--VTHCRLILRS--LPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 347
Cdd:cd04388   92 EMISRAQEVQSSDeyAQLLRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFS 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
27-154 7.15e-09

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 54.18  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568993488   27 GDDRQGRRIFTFSCCRLPPlHQLNHQRLLEYLKYTLDQ--------HVENdYTIVY-FHyGLSSQNKPSLG--------- 88
Cdd:pfam00650   8 GRDKEGRPVLYLRLGRHDP-KKSSEEELVRFLVLVLERalllmpegQVEG-LTVIIdLK-GLSLSNMDWWSisllkkiik 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568993488   89 WLQNTYKEfdrkykkNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC--SNLRELREHLQCDQL 154
Cdd:pfam00650  85 ILQDNYPE-------RLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLknSNEEELEKYIPPEQL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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