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Conserved domains on  [gi|568991291|ref|XP_006520471|]
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meiotic recombination protein DMC1/LIM15 homolog isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
recomb_DMC1 super family cl31185
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 24-282 2.61e-163

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


The actual alignment was detected with superfamily member TIGR02238:

Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 455.78  E-value: 2.61e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   24 IDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITT 103
Cdd:TIGR02238   1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  104 GSQEFD--------------------------------------------------------RPDRLRDIADRFNVDHEA 127
Cdd:TIGR02238  81 GSQALDgilgggiesmsitevfgefrcgktqlshtlcvtaqlpremgggngkvayidtegtfRPDRIRAIAERFGVDPDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  128 VLDNVLYARAYTSEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 207
Cdd:TIGR02238 161 VLDNILYARAYTSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568991291  208 VFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDA 282
Cdd:TIGR02238 239 VFVTNQVQADPGATMTFIADPKKPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQITEGGIADA 313
 
Name Accession Description Interval E-value
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 24-282 2.61e-163

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 455.78  E-value: 2.61e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   24 IDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITT 103
Cdd:TIGR02238   1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  104 GSQEFD--------------------------------------------------------RPDRLRDIADRFNVDHEA 127
Cdd:TIGR02238  81 GSQALDgilgggiesmsitevfgefrcgktqlshtlcvtaqlpremgggngkvayidtegtfRPDRIRAIAERFGVDPDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  128 VLDNVLYARAYTSEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 207
Cdd:TIGR02238 161 VLDNILYARAYTSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568991291  208 VFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDA 282
Cdd:TIGR02238 239 VFVTNQVQADPGATMTFIADPKKPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQITEGGIADA 313
PTZ00035 PTZ00035
Rad51 protein; Provisional
 2-284 1.25e-146

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 414.40  E-value: 1.25e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   2 KEDQVVQEESGfqDDEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLI 81
Cdd:PTZ00035   3 ESQNEQQEEEE--EEEAEGFQEIEKLQSAGINAADIKKLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  82 EPGFLTAFQYSERRKMVFHITTGSQEFD---------------------------------------------------- 109
Cdd:PTZ00035  81 PMGFISATEYLEARKNIIRITTGSTQLDkllgggietgsitelfgefrtgktqlchtlcvtcqlpieqgggegkvlyidt 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 ----RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAE 185
Cdd:PTZ00035 161 egtfRPERIVQIAERFGLDPEDVLDNIAYARAYNHEHQMQLLSQAAAKMAEER--FALLIVDSATALFRVDYSGRGELAE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 186 RQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEM 265
Cdd:PTZ00035 239 RQQHLGKFLRALQKLADEFNVAVVITNQVMADVDGASMFVADPKKPIGGHIIAHASTTRLSLRKGRGEQRICKIYDSPNL 318

                        330
                 ....*....|....*....
gi 568991291 266 PENEATFAITAGGIGDAKE 284
Cdd:PTZ00035 319 PESEAVFAISEGGIIDAKD 337
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 110-281 1.90e-134

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 379.78  E-value: 1.90e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgIFKLLIIDSIMALFRVDFSGRGELAERQQK 189
Cdd:cd19514   66 RPDRIRPIAERFGVDHDAVLDNILYARAYTSEHQMELLDYVAAKFHEEA-VFRLLIIDSIMALFRVDFSGRGELAERQQK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd19514  145 LAQMLSRLQKISEEYNVAVFITNQVTADPGAAMTFQADPKKPIGGHILAHASTTRISLRKGRGEERIAKIYDSPDLPENE 224

                        170
                 ....*....|..
gi 568991291 270 ATFAITAGGIGD 281
Cdd:cd19514  225 ATFAITAGGIAD 236
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 84-282 1.52e-103

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 301.91  E-value: 1.52e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   84 GFLTAFQYSERRKMVFHITTGSQEFD------------------------------------------------------ 109
Cdd:pfam08423   2 GFTTATELHQRRSELIQITTGSKELDkllgggietgsiteifgefrtgktqlchtlcvtcqlplemgggegkalyidteg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  110 --RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQ 187
Cdd:pfam08423  82 tfRPERLVAIAERYGLDPEDVLDNVAYARAYNSEHQMQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELAERQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  188 QKLAQMLSRLQKISEEYNVAVFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMP 266
Cdd:pfam08423 160 QHLAKFLRTLQRLADEFGVAVVITNQVVAQVdGAAGMFSGDPKKPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSPCLP 239

                         250
                  ....*....|....*.
gi 568991291  267 ENEATFAITAGGIGDA 282
Cdd:pfam08423 240 ESEAVFAIGSGGIIDP 255
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
118-250 1.66e-10

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 60.57  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 118 ADRFNVDheavLDNVLYARAYTSEHQMELLDYVAakfheEAGIFKLLIIDSIMALF-RVDFSGR---GELAERQQKLAQM 193
Cdd:COG0468  108 AKKLGVD----IDNLLVSQPDTGEQALEIAETLV-----RSGAVDLIVVDSVAALVpKAEIEGEmgdSHVGLQARLMSQA 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568991291 194 LSRLQKISEEYNVAVFVTNQMTADPGatMTFqADPKKPIGGHILAHASTTRISLRKG 250
Cdd:COG0468  179 LRKLTGAISKSNTTVIFINQLREKIG--VMF-GNPETTTGGNALKFYASVRLDIRRI 232
 
Name Accession Description Interval E-value
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 24-282 2.61e-163

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 455.78  E-value: 2.61e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   24 IDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITT 103
Cdd:TIGR02238   1 IDKLQAHGINAADIKKLKSAGICTVNGVIMTTRRALCKIKGLSEAKVDKIKEAASKIINPGFITAFEISQKRKKVLKITT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  104 GSQEFD--------------------------------------------------------RPDRLRDIADRFNVDHEA 127
Cdd:TIGR02238  81 GSQALDgilgggiesmsitevfgefrcgktqlshtlcvtaqlpremgggngkvayidtegtfRPDRIRAIAERFGVDPDA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  128 VLDNVLYARAYTSEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 207
Cdd:TIGR02238 161 VLDNILYARAYTSEHQMELLDYLAAKFSEE--PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568991291  208 VFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDA 282
Cdd:TIGR02238 239 VFVTNQVQADPGATMTFIADPKKPIGGHVLAHASTTRILLRKGRGEERVAKLYDSPDMPEAEASFQITEGGIADA 313
PTZ00035 PTZ00035
Rad51 protein; Provisional
 2-284 1.25e-146

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 414.40  E-value: 1.25e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   2 KEDQVVQEESGfqDDEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLI 81
Cdd:PTZ00035   3 ESQNEQQEEEE--EEEAEGFQEIEKLQSAGINAADIKKLKEAGICTVESVAYATKKDLCNIKGISEAKVEKIKEAASKLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  82 EPGFLTAFQYSERRKMVFHITTGSQEFD---------------------------------------------------- 109
Cdd:PTZ00035  81 PMGFISATEYLEARKNIIRITTGSTQLDkllgggietgsitelfgefrtgktqlchtlcvtcqlpieqgggegkvlyidt 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 ----RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAE 185
Cdd:PTZ00035 161 egtfRPERIVQIAERFGLDPEDVLDNIAYARAYNHEHQMQLLSQAAAKMAEER--FALLIVDSATALFRVDYSGRGELAE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 186 RQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEM 265
Cdd:PTZ00035 239 RQQHLGKFLRALQKLADEFNVAVVITNQVMADVDGASMFVADPKKPIGGHIIAHASTTRLSLRKGRGEQRICKIYDSPNL 318

                        330
                 ....*....|....*....
gi 568991291 266 PENEATFAITAGGIGDAKE 284
Cdd:PTZ00035 319 PESEAVFAISEGGIIDAKD 337
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 110-281 1.90e-134

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 379.78  E-value: 1.90e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgIFKLLIIDSIMALFRVDFSGRGELAERQQK 189
Cdd:cd19514   66 RPDRIRPIAERFGVDHDAVLDNILYARAYTSEHQMELLDYVAAKFHEEA-VFRLLIIDSIMALFRVDFSGRGELAERQQK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd19514  145 LAQMLSRLQKISEEYNVAVFITNQVTADPGAAMTFQADPKKPIGGHILAHASTTRISLRKGRGEERIAKIYDSPDLPENE 224

                        170
                 ....*....|..
gi 568991291 270 ATFAITAGGIGD 281
Cdd:cd19514  225 ATFAITAGGIAD 236
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 5-284 2.12e-124

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 358.32  E-value: 2.12e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   5 QVVQEESGfqDDEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPG 84
Cdd:PLN03187  14 QLVEAEEV--DEEEDLFESIDKLISQGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKICEAAEKLLNQG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  85 FLTAFQYSERRKMVFHITTGSQEFD------------------------------------------------------- 109
Cdd:PLN03187  92 FITGSDALLKRKSVVRITTGSQALDellgggietrciteafgefrsgktqlahtlcvttqlptemgggngkvayidtegt 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 -RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQ 188
Cdd:PLN03187 172 fRPDRIVPIAERFGMDADAVLDNIIYARAYTYEHQYNLLLGLAAKMAEEP--FRLLIVDSVIALFRVDFTGRGELAERQQ 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 189 KLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPEN 268
Cdd:PLN03187 250 KLAQMLSRLTKIAEEFNVAVYMTNQVIADPGG-GMFISDPKKPAGGHVLAHAATIRLMLRKGKGEQRVCKVFDAPNLPEA 328

                        330
                 ....*....|....*.
gi 568991291 269 EATFAITAGGIGDAKE 284
Cdd:PLN03187 329 EAEFQITSGGIMDAKD 344
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 24-284 3.35e-109

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 318.59  E-value: 3.35e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   24 IDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITT 103
Cdd:TIGR02239   1 IEKLEGNGITAADIKKLQEAGLHTVESVAYAPKKQLLEIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRQEVIQLTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  104 GSQEFD--------------------------------------------------------RPDRLRDIADRFNVDHEA 127
Cdd:TIGR02239  81 GSKELDkllgggietgsiteifgefrtgktqlchtlavtcqlpidqgggegkalyidtegtfRPERLLAIAERYGLNPED 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  128 VLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 207
Cdd:TIGR02239 161 VLDNVAYARAYNTDHQLQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADEFGVA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568991291  208 VFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE 284
Cdd:TIGR02239 239 VVITNQVVAQVdGAGSMFAGDPKKPIGGNIMAHASTTRLSLRKGRGEQRICKIYDSPCLPESEAMFAIYEDGIGDPKE 316
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 110-280 5.06e-109

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 315.24  E-value: 5.06e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEagIFKLLIIDSIMALFRVDFSGRGELAERQQK 189
Cdd:cd01123   66 RPERLRAIAQRFGLDPDDVLDNVAYARAFNSDHQTQLLDQAAAMMVES--RFKLLIVDSATALYRTDYSGRGELSARQMH 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd01123  144 LAKFLRMLQRLADEFGVAVVVTNQVVAQVDGAMMFAADPKKPIGGNILAHASTTRLYLRKGRGETRICKIYDSPCLPEAE 223

                        170
                 ....*....|.
gi 568991291 270 ATFAITAGGIG 280
Cdd:cd01123  224 AVFAITADGVG 234
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 24-284 1.24e-106

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 313.21  E-value: 1.24e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  24 IDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITT 103
Cdd:PLN03186  28 IEQLQASGIAALDIKKLKDAGIHTVESLAYAPKKDLLQIKGISEAKVEKILEAASKLVPLGFTTASQLHAQRQEIIQITT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 104 GSQEFD--------------------------------------------------------RPDRLRDIADRFNVDHEA 127
Cdd:PLN03186 108 GSRELDkileggietgsiteiygefrtgktqlchtlcvtcqlpldqgggegkamyidtegtfRPQRLIQIAERFGLNGAD 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 128 VLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVA 207
Cdd:PLN03186 188 VLENVAYARAYNTDHQSELLLEAASMMAETR--FALMIVDSATALYRTEFSGRGELSARQMHLGKFLRSLQRLADEFGVA 265

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568991291 208 VFVTNQMTADPGAtMTFQADPK-KPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE 284
Cdd:PLN03186 266 VVITNQVVAQVDG-SAFFAGPQlKPIGGNIMAHASTTRLALRKGRGENRICKVISSPCLPEAEARFSISSEGVTDVKD 342
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 84-282 1.52e-103

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 301.91  E-value: 1.52e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   84 GFLTAFQYSERRKMVFHITTGSQEFD------------------------------------------------------ 109
Cdd:pfam08423   2 GFTTATELHQRRSELIQITTGSKELDkllgggietgsiteifgefrtgktqlchtlcvtcqlplemgggegkalyidteg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  110 --RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQ 187
Cdd:pfam08423  82 tfRPERLVAIAERYGLDPEDVLDNVAYARAYNSEHQMQLLQQAAAMMSESR--FALLIVDSATALYRTDFSGRGELAERQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  188 QKLAQMLSRLQKISEEYNVAVFVTNQMTADP-GATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMP 266
Cdd:pfam08423 160 QHLAKFLRTLQRLADEFGVAVVITNQVVAQVdGAAGMFSGDPKKPIGGHIMAHASTTRLSLRKGRGEQRICKIYDSPCLP 239

                         250
                  ....*....|....*.
gi 568991291  267 ENEATFAITAGGIGDA 282
Cdd:pfam08423 240 ESEAVFAIGSGGIIDP 255
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
 110-281 2.98e-92

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 272.65  E-value: 2.98e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAgiFKLLIIDSIMALFRVDFSGRGELAERQQK 189
Cdd:cd19513   66 RPERLLAIAERYGLNGEDVLDNVAYARAYNTDHQMQLLIQASAMMAESR--YALLIVDSATALYRTDYSGRGELSARQMH 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd19513  144 LAKFLRMLQRLADEFGVAVVITNQVVAQVDGAAMFAGDPKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSPCLPEAE 223

                        170
                 ....*....|..
gi 568991291 270 ATFAITAGGIGD 281
Cdd:cd19513  224 AVFAITEDGIGD 235
radA PRK04301
DNA repair and recombination protein RadA; Validated
 23-282 1.42e-80

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 245.94  E-value: 1.42e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  23 DIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIE-PGFLTAFQYSERRKMVFHI 101
Cdd:PRK04301   5 EKDLEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGESTAAKIIEAAREAADiGGFETALEVLERRKNVGKI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 102 TTGSQEFD--------------------------------------------------------RPDRLRDIADRFNVDH 125
Cdd:PRK04301  85 TTGSKELDellgggietqsitefygefgsgktqichqlavnvqlpeekgglegkavyidtegtfRPERIEQMAEALGLDP 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 126 EAVLDNVLYARAYTSEHQMELLDYvAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYN 205
Cdd:PRK04301 165 DEVLDNIHVARAYNSDHQMLLAEK-AEELIKEGENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYN 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568991291 206 VAVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDA 282
Cdd:PRK04301 244 AAVVVTNQVMARPDA---FFGDPTQPIGGHILGHTATFRIYLRKSKGNKRIARLVDSPHLPEGEAVFRITEEGIRDA 317
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 31-281 1.20e-74

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 230.40  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291   31 GINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPG-FLTAFQYSERRKMVFHITTGSQEFD 109
Cdd:TIGR02236   6 GVGPATAEKLREAGYDTFEAIAVASPKELSEIAGISEGTAAKIIQAARKAADLGgFETADDVLERRKTIGKITTGSKELD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  110 --------------------------------------------------------RPDRLRDIADRFNVDHEAVLDNVL 133
Cdd:TIGR02236  86 ellgggietqaitevfgefgsgktqichqlavnvqlpeekgglggkavyidtentfRPERIMQMAEARGLDPDEVLKNIY 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  134 YARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQ 213
Cdd:TIGR02236 166 VARAYNSNHQMLLVEKAEDLIKELNNPVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVVVTNQ 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568991291  214 MTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGD 281
Cdd:TIGR02236 246 VMARPDA---FFGDPTRPIGGHILGHAATFRVYLRKGKGDKRIARLVDSPHLPEGEAVFRITEKGIED 310
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 110-281 3.09e-67

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 209.14  E-value: 3.09e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIfKLLIIDSIMALFRVDFSGRGELAERQQK 189
Cdd:cd19515   66 RPERIMQMAKALGLDPDEVLDNIYVARAYNSNHQMLLVEKAEDLIKEGNNI-KLLIVDSLTSHFRAEYVGRGTLAERQQK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADPGAtmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd19515  145 LNKHLHDLHRLADLYNIAVLVTNQVMAKPDA---FFGDPTQAIGGHILGHAATFRVYLRKGKGGKRIARLVDSPHLPEGE 221

                        170
                 ....*....|..
gi 568991291 270 ATFAITAGGIGD 281
Cdd:cd19515  222 AVFRITEKGIED 233
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 110-249 3.50e-29

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 109.36  E-value: 3.50e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 110 RPDRLRDIA---DRFNVDHEAVLDNVLYARAYTSEHQMELLDYvaakfHEEAGI----FKLLIIDSIMALFRVDF----S 178
Cdd:cd01393   42 PPSRLVQILeasPSSELELAEALSRLLYFRPPDTLAHLLALDS-----LPESLFpppnTSLVVVDSVSALFRKAFprggD 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568991291 179 GRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGAtmTFQADPKKPIGGHILAHASTTRISLRK 249
Cdd:cd01393  117 GDSSSSLRARLLSQLARALQKLAAQFNLAVVVTNQVTTKIRG--GSGASLVPPALGNTWEHSVSTRLLLYR 185
radB PRK09361
DNA repair and recombination protein RadB; Provisional
 111-279 4.18e-23

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 94.16  E-value: 4.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 111 PDRLRDIADRfnvDHEAVLDNVLYARAYTSEHQ----MELLDYVAAKFheeagifKLLIIDSIMALFRVDFSGRGELAER 186
Cdd:PRK09361  64 PERFKQIAGE---DFEELLSNIIIFEPSSFEEQseaiRKAEKLAKENV-------GLIVLDSATSLYRLELEDEEDNSKL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 187 QQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTfqadpkKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMP 266
Cdd:PRK09361 134 NRELGRQLTHLLKLARKHDLAVVITNQVYSDIDSDGL------RPLGGHTLEHWSKTILRLEKFRNGKRRATLEKHRSRP 207

                        170
                 ....*....|....
gi 568991291 267 ENE-ATFAITAGGI 279
Cdd:PRK09361 208 EGEsAEFRITDRGI 221
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 100-249 1.60e-20

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 88.12  E-value: 1.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 100 HITTgsqEFDRP-DRLRDIADRF-----NVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIfKLLIIDSIMALF 173
Cdd:cd19491   51 YICT---ESSFPsKRLQQLASSLpkryhLEKAKNFLDNIFVEHVADLETLEHCLNYQLPALLERGPI-RLVVIDSIAALF 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 174 RVDF-SGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGA---------------TMTFQADP----KKPIG 233
Cdd:cd19491  127 RSEFdTSRSDLVERAKYLRRLADHLKRLADKYNLAVVVVNQVTDRFDSssdasglgvldylsqFSSFSGGVsgnrKVPAL 206

                        170
                 ....*....|....*.
gi 568991291 234 GHILAHASTTRISLRK 249
Cdd:cd19491  207 GLTWANLVNTRLMLSR 222
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 111-279 7.35e-20

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 85.44  E-value: 7.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 111 PDRLRDIA-DRFnvdhEAVLDNVLYARAYTSEHQMELLDYvAAKFhEEAGIFKLLIIDSIMALFRVDfsgRGELAERQQK 189
Cdd:cd01394   60 PERFQQIAgERF----ESIASNIIVFEPYSFDEQGVAIQE-AEKL-LKSDKVDLVVVDSATALYRLE---LGDDSEANRE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQMTADpgatmtFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENE 269
Cdd:cd01394  131 LSRQMSKLLSIARKYDIPVVITNQVYSD------IDDDRLKPVGGTLLEHWSKAIIRLEKSPPGLRRATLEKHRSRPEGQ 204

                        170
                 ....*....|.
gi 568991291 270 -ATFAITAGGI 279
Cdd:cd01394  205 sAGFRITDRGI 215
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 100-263 2.70e-18

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 81.21  E-value: 2.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 100 HITTGSQEFDRPDRLRDIADRFNVDHEAVLDNVLyaraytsEHQMELLDYVAAKfheeaGIfKLLIIDSIMALFRVDFSG 179
Cdd:cd19493   70 FPEAFSGFMEENERAEEMLKRVAVVRVTTLAQLL-------ERLPNLEEHILSS-----GV-RLVVIDSIAALVRREFGG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 180 -RGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIgGHILAHASTTRISLRKGRG-ELRIA 257
Cdd:cd19493  137 sDGEVTERHNALAREASSLKRLAEEFRIAVLVTNQATTHFGDAGDGSSGVTAAL-GDAWAHAVNTRLRLERCLLqLRRVL 215


                 ....*.
gi 568991291 258 KIYDSP 263
Cdd:cd19493  216 EIVKSP 221
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 131-263 2.94e-15

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 71.87  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 131 NVLYARAYTSEHQMELLDYVAAKFHEEAGIfKLLIIDSIMALFRVDFSGrgeLAERQQKLAQMLSRLQKISEEYNVAVFV 210
Cdd:cd19492   48 NIHYFRVHDYVELLALINSLPKFLEDHPKV-KLIVVDSIAFPFRHDFDD---LAQRTRLLNGLAQLLHSLARQHNLAVVL 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568991291 211 TNQMTADPGATMTFQAdpkKPIGGHILAHASTTRISLRKGRGElRIAKIYDSP 263
Cdd:cd19492  124 TNQVTTKISEDGQSQL---VPALGESWSHACTTRLFLTWDEKQ-RFAHLYKSP 172
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
118-250 1.66e-10

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 60.57  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 118 ADRFNVDheavLDNVLYARAYTSEHQMELLDYVAakfheEAGIFKLLIIDSIMALF-RVDFSGR---GELAERQQKLAQM 193
Cdd:COG0468  108 AKKLGVD----IDNLLVSQPDTGEQALEIAETLV-----RSGAVDLIVVDSVAALVpKAEIEGEmgdSHVGLQARLMSQA 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568991291 194 LSRLQKISEEYNVAVFVTNQMTADPGatMTFqADPKKPIGGHILAHASTTRISLRKG 250
Cdd:COG0468  179 LRKLTGAISKSNTTVIFINQLREKIG--VMF-GNPETTTGGNALKFYASVRLDIRRI 232
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 97-249 3.72e-08

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 52.64  E-value: 3.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291  97 MVFHITTGSqEFDrPDRLRDIAD-RFNVDHE--AVLDNVLYARAYTSEHQMELLDYVAAKFHEE----AGIFKLLIIDSI 169
Cdd:cd19489   38 NVLYIDTKS-SFS-ARRLAQILKsRAQDAEEidKALQRIRVVRVFDPYELLDLLEELRNTLSQQqenlYSRLKLVIIDSL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 170 MALFRVDFSGrgelAERQQKLAQM--LSR-LQKISEEYNVAVFVTNQMTADPGatMTFQADPkKPIGGHILAHASTTRIS 246
Cdd:cd19489  116 SALISPLLGG----SKHSEGHALLasLARlLKKLAAEYQIAVLVTNLTVRGGD--GGQQGST-KPALGEYWESVPSTRLL 188


                 ...
gi 568991291 247 LRK 249
Cdd:cd19489  189 LSR 191
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 123-249 5.00e-06

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 46.57  E-value: 5.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 123 VDHEAV----LDNVLYARAYTSEH---QMELLDYVAAK--FHEEAGifkLLIIDSIMALFRVDFSGRGELAERQQK---- 189
Cdd:cd19490   79 EDVEEIarecLQRLHIFRCHSSLQllaTLLSLENYLLSlsANPELG---LLLIDSISAFYWQDRFSAELARAAPLLqeaa 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568991291 190 LAQMLSRLQKISEEYNVAVFVTNQM-----------TADPGATMTFQADPKKPIGGHILAHASTTRISLRK 249
Cdd:cd19490  156 LRAILRELRRLRRRFQLVVIATKQAlfpgksastdnPAANNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
109-279 1.53e-04

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 41.82  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 109 DRPDRLRDIADRFNVDHEAVLDN--VLYARAYTSEHQM---ELLDYVAAKFHEEAGifKLLIIDSIMALFRvdfsgrgeL 183
Cdd:COG0467   58 ESPEQLLRRAESLGLDLEEYIESglLRIIDLSPEELGLdleELLARLREAVEEFGA--KRVVIDSLSGLLL--------A 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991291 184 AERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGatmtfqadpkkPIGGHILAHASTTRISLRK--GRGE----LRIA 257
Cdd:COG0467  128 LPDPERLREFLHRLLRYLKKRGVTTLLTSETGGLED-----------EATEGGLSYLADGVILLRYveLGGElrraLSVL 196

                        170       180
                 ....*....|....*....|..
gi 568991291 258 KIYDSPeMPENEATFAITAGGI 279
Cdd:COG0467  197 KMRGSA-HDRTIREFEITDGGI 217
HHH_5 pfam14520
Helix-hairpin-helix domain;
25-79 1.74e-04

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 38.62  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568991291   25 DLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANK 79
Cdd:pfam14520   3 ELLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPGIGEKTAQRIILELRD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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