|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
939-1316 |
2.63e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.89 E-value: 2.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 939 SATPQQYHPNGP--FGRSQRQASPVQTHPKSRQmSRTLERSGTVVSRVGHGRSLGSQARRAAGKPQPEKAcaqglqLTKA 1016
Cdd:PHA03247 2615 SPLPPDTHAPDPppPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP------RRRA 2687
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1017 AGKSIRTLPHIKYPHPQPCQPAGASQERI----MPVSHQGAQQTTQGRPADFA--------FKPGSQSTSGSKLSSTSQS 1084
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVsatpLPPGPAAARQASPALPAAPAppavpagpATPGGPARPARPPTTAGPP 2767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1085 SAHQPKFQSKhfQPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSH 1164
Cdd:PHA03247 2768 APAPPAAPAA--GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1165 AKPSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSH-AKPSHPQSSHAKPsHPQSSQAKPSHPQSSQAKPTHPQSS 1243
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFA-LPPDQPERPPQPQAPPPPQPQPQPP 2924
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907112372 1244 QANSHHPQ-ASQAKPSHPQSSHAKPS-HPHPSHAKPSPSQST----QCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQAR 1316
Cdd:PHA03247 2925 PPPQPQPPpPPPPRPQPPLAPTTDPAgAGEPSGAVPQPWLGAlvpgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1086-1320 |
1.84e-11 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 69.03 E-value: 1.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1086 AHQPKFQSKHFQPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLT-QGQPSQATPTHSQASQAKPTHSQANSHHPHPSH 1164
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPpQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1165 AKPSHQNPSHANPTHPQSSHAKPSHPQSSH--AKPSHPQSSHAKPSHPQsshakpsHPQSSQAKPSHPQSSQAK------ 1236
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPLPQPSLhgQMPPMPHSLQTGPSHMQ-------HPVPPQPFPLTPQSSQSQvppgps 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1237 PTHPQSSQANSHHPqASQAKPSHPQSSHAKPSHPHP---SHAKPSPSQ------STQCKAHKAHQSQPKPFQPRPTQPKS 1307
Cdd:pfam03154 315 PAAPGQSQQRIHTP-PSQSQLQSQQPPREQPLPPAPlsmPHIKPPPTTpipqlpNPQSHKHPPHLSGPSPFQMNSNLPPP 393
|
250
....*....|....
gi 1907112372 1308 SKTKP-SQARAFHP 1320
Cdd:pfam03154 394 PALKPlSSLSTHHP 407
|
|
| CARD |
cd01671 |
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ... |
161-229 |
2.11e-11 |
|
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260018 [Multi-domain] Cd Length: 79 Bit Score: 60.99 E-value: 2.11e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907112372 161 IEKKRTKLLSVLqqDPDSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCL 229
Cdd:cd01671 1 LRKNRVELVEDL--DVEDILDHLIQKGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVFCEAL 67
|
|
| CARD |
pfam00619 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. ... |
159-238 |
5.65e-10 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.
Pssm-ID: 459874 [Multi-domain] Cd Length: 85 Bit Score: 57.18 E-value: 5.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 159 ELIEKKRTKLLSVLQqDPDSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCLSNAFPESAS 238
Cdd:pfam00619 2 KLLKKNRVALVERLG-TLDGLLDYLLEKNVLTEEEEEKIKANPTRLDKARELLDLVLKKGPKACQIFLEALKEGDPDLAS 80
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
1088-1314 |
1.47e-09 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 62.75 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1088 QPKFQSKHFQPQPFQPVPSQKKPSHSRPSQAKPP-----------------HLDPSHANLTQGQPSQATPTHSQASQAKP 1150
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvrtgyekykepepipdlQVDASLWGVAPKKAAAPAPAPQPAAQPAS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1151 THSQ---------------ANSHHPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQsshakpsHPQSSHAKPSHPQSsHA 1215
Cdd:pfam09770 186 LPAPsrkmmsleeveaamrAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQ-------QQQQPQQQPQQPQQ-HP 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1216 KPSHPQSSQakpSHPQSSQAKPTHPQSSQANSHHPQasQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQP 1295
Cdd:pfam09770 258 GQGHPVTIL---QRPQSPQPDPAQPSIQPQAQQFHQ--QPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQA 332
|
250
....*....|....*....
gi 1907112372 1296 KPFQPRPTQPKSSKTKPSQ 1314
Cdd:pfam09770 333 HRQQGSFGRQAPIITHPQQ 351
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
988-1320 |
4.17e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 4.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 988 RSLGSQARRAAGKPQPEKACAQglqLTKAAGKSIRTlphiKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPADfafk 1067
Cdd:PHA03247 2538 RGLEELASDDAGDPPPPLPPAA---PPAAPDRSVPP----PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRG---- 2606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1068 pgsqSTSGSKLSSTSQSSAHQPKfqskhfqPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHAnltqgQPSQATPTHSQASQ 1147
Cdd:PHA03247 2607 ----DPRGPAPPSPLPPDTHAPD-------PPPPSPSPAANEPDPHPPPTVPPPERPRDDP-----APGRVSRPRRARRL 2670
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1148 AKPTHSQANSHHPHPSHAKPshqnpshanPTHPQSSHAKPsHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQS----- 1222
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARP---------TVGSLTSLADP-PPPPPTPEPAPHALVSATPLPPGPAAARQASPALpaapa 2740
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1223 ------------SQAKPSHPQSSqAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKA 1290
Cdd:PHA03247 2741 ppavpagpatpgGPARPARPPTT-AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
|
330 340 350
....*....|....*....|....*....|
gi 1907112372 1291 HQSQPKPFQPRPTQPksSKTKPSQARAFHP 1320
Cdd:PHA03247 2820 PAASPAGPLPPPTSA--QPTAPPPPPGPPP 2847
|
|
| CARD |
smart00114 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. ... |
158-232 |
1.16e-08 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
Pssm-ID: 128424 Cd Length: 88 Bit Score: 53.50 E-value: 1.16e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 158 SELIEKKRTKLLSVLQqdPDSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCLSNA 232
Cdd:smart00114 6 KRLLRRNRVRLGEELG--VDGLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSLQET 78
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
1106-1282 |
1.33e-07 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 56.62 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1106 SQKKPSHSRPSQAKPPHLDPSHANLT---QGQPsQATPTHSQASQAKPTHS---QANSHHPHPSHAKPSHQNPSHANPTH 1179
Cdd:PTZ00395 351 SAGAPFNGLGNQADGGHINQVHPDARgawAGGP-HSNASYNCAAYSNAAQSnaaQSNAGFSNAGYSNPGNSNPGYNNAPN 429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1180 PQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSH---PQSSQAKpsHPQSSQAKPTHPQSSQANSHHPQASQAK 1256
Cdd:PTZ00395 430 SNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAPLsnaPPSSAKD--HHSAYHAAYQHRAANQPAANLPTANQPA 507
|
170 180
....*....|....*....|....*.
gi 1907112372 1257 PSHPQSSHAKpSHPHPSHAKPSPSQS 1282
Cdd:PTZ00395 508 ANNFHGAAGN-SVGNPFASRPFGSAP 532
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1098-1323 |
3.91e-07 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 54.69 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1098 PQPFQPV--PSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSH-------AKPS 1168
Cdd:PHA03378 571 PLQIQPLtsPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQpitfnvlVFPT 650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1169 HQNPSHANPTHPQSSHAKPSHPqsshakPSHPQSSHAKPSHPQSshAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSH 1248
Cdd:PHA03378 651 PHQPPQVEITPYKPTWTQIGHI------PYQPSPTGANTMLPIQ--WAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATG 722
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 1249 HPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQarafHPRAG 1323
Cdd:PHA03378 723 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQ----RPRGA 793
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
1030-1222 |
4.67e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 54.27 E-value: 4.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1030 PHPQPCQPAGASQER-IMPVSHQGAQQTTQgrpadfAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQK 1108
Cdd:pfam09770 177 PQPAAQPASLPAPSRkMMSLEEVEAAMRAQ------AKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1109 KPSHSRPSQAKPPHLdpshanLTQGQPSQATPTHSQASQAKPTHSQanshhphpsHAKPSHQNPSH--ANPTHPQSSHAK 1186
Cdd:pfam09770 251 QQPQQHPGQGHPVTI------LQRPQSPQPDPAQPSIQPQAQQFHQ---------QPPPVPVQPTQilQNPNRLSAARVG 315
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907112372 1187 PSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQS 1222
Cdd:pfam09770 316 YPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQ 351
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1032-1282 |
5.51e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 54.41 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1032 PQPCQPAGASQERIMPVSHQGAQQTTQ-GRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKKP 1110
Cdd:PHA03307 126 PPPSPAPDLSEMLRPVGSPGPPPAASPpAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPR 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1111 SHSRPSQAKPPHLDPSHANL-TQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHA----KPSHQNPSHANPTHPQSSHA 1185
Cdd:PHA03307 206 PPRRSSPISASASSPAPAPGrSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitlPTRIWEASGWNGPSSRPGPA 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1186 KPSHP---QSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSsqanSHHPQASQAKPSHPQS 1262
Cdd:PHA03307 286 SSSSSpreRSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGP----SPSRSPSPSRPPPPAD 361
|
250 260
....*....|....*....|
gi 1907112372 1263 SHAKPSHPHPSHAKPSPSQS 1282
Cdd:PHA03307 362 PSSPRKRPRPSRAPSSPAAS 381
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1097-1325 |
6.92e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 54.02 E-value: 6.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1097 QPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHAN 1176
Cdd:PHA03307 171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1177 PThpqsSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHP---QSSQAKPSHPQSSQAKPTHPQSSQANSHHPQAS 1253
Cdd:PHA03307 251 PE----NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSpreRSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS 326
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907112372 1254 QAKPSHPQSSHAKPSHPHPSHAKP----SPSQSTQCKAhKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPRAGRR 1325
Cdd:PHA03307 327 SSTSSSSESSRGAAVSPGPSPSRSpspsRPPPPADPSS-PRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRR 401
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
1086-1281 |
8.61e-07 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 53.20 E-value: 8.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1086 AHQPKFQSKHFQPQPfQPVPSQKKPSHSRPSQAKPPHLDPSHA--NLTQGQPSQATPT-----HSQASQAKPTHSQANSH 1158
Cdd:pfam05110 100 LPPSFHTSSHSQPMG-PPSSSSPSVSSSQSQKKSQARTEPAHGghSSSGSQSSQRSQGqsrskGGQESHSSSHHKRQERR 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1159 HPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQSShakpSHPQSSHAKPShpqsshAKPSHPQSSQAKPshpqssqakpt 1238
Cdd:pfam05110 179 EDLFSCASLSHSLEELSPLLSSLSSPVKPLSPSHS----RQHTGSKAQNS------SDHHGKEYSHSKS----------- 237
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1907112372 1239 hPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQ 1281
Cdd:pfam05110 238 -PRDSEAGSHGPESPSTSLLASSSQLSSQTFPPSLPSKTSAMQ 279
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1114-1301 |
1.16e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 53.15 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1114 RPSQAKPPHLDPSHANLTQGQPSqaTPTHSQASQAKPTHSQANSHHPHPShaKPSHQNPSHANP-THPQSSHAKPSHPQS 1192
Cdd:PTZ00449 490 KKSKKKLAPIEEEDSDKHDEPPE--GPEASGLPPKAPGDKEGEEGEHEDS--KESDEPKEGGKPgETKEGEVGKKPGPAK 565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1193 SHaKPSHPQSSHAKPSHPQsshaKPSHPQ--SSQAKPSHPQSSQaKPTHPQSSQanshHPQA-----SQAKPSHPQSSHA 1265
Cdd:PTZ00449 566 EH-KPSKIPTLSKKPEFPK----DPKHPKdpEEPKKPKRPRSAQ-RPTRPKSPK----LPELldipkSPKRPESPKSPKR 635
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907112372 1266 KPSHPHPSHAKpSPSQSTQCKAHKAHQSQPKPFQPR 1301
Cdd:PTZ00449 636 PPPPQRPSSPE-RPEGPKIIKSPKPPKSPKPPFDPK 670
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1030-1315 |
1.64e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.85 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1030 PHPQPCQPAGASQERIMPVSHQGAQQ----TTQGRPADF-------AFKPGSQSTSGSKLSSTSQSSAHQPkfQSKHFQP 1098
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPpmphSLQTGPSHMqhpvppqPFPLTPQSSQSQVPPGPSPAAPGQS--QQRIHTP 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1099 qPFQPVPSQKKPSHSRPSQAKP---PHLDPSHANLTQGQPSQATPTHSqASQAKPTHSQANSHHPHPSHAKPSHQNPSHA 1175
Cdd:pfam03154 329 -PSQSQLQSQQPPREQPLPPAPlsmPHIKPPPTTPIPQLPNPQSHKHP-PHLSGPSPFQMNSNLPPPPALKPLSSLSTHH 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1176 NPT-HP---------QSSHAKPSHPQSSHAKPSHPQSShakpshpqSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQA 1245
Cdd:pfam03154 407 PPSaHPpplqlmpqsQQLPPPPAQPPVLTQSQSLPPPA--------ASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPP 478
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 1246 NSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPS-PSQSTQCKAHKAHQSQ----PKPFQPRPTQPKSSKTKPSQA 1315
Cdd:pfam03154 479 SGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVScPLPPVQIKEEALDEAEepesPPPPPRSPSPEPTVVNTPSHA 553
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1031-1322 |
1.69e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 52.76 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1031 HPQPCQPAGASQERIMPVSHQGAQQTTQGRPADFA---FKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQ 1107
Cdd:PHA03378 560 HDQLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQtpwPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQ 639
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1108 KKPSH--SRPSQAKPPHLDPSHANLTQGQ----PSQATPTHSQAS---QAKPTHSQANSHHP-------------HPSHA 1165
Cdd:PHA03378 640 PITFNvlVFPTPHQPPQVEITPYKPTWTQighiPYQPSPTGANTMlpiQWAPGTMQPPPRAPtpmrppaappgraQRPAA 719
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1166 KPSHQNPSHANPTHPQSSHAKPSH---PQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQS 1242
Cdd:PHA03378 720 ATGRARPPAAAPGRARPPAAAPGRarpPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPP 799
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1243 SQANshhPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPRA 1322
Cdd:PHA03378 800 PQAG---PTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPV 876
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
952-1279 |
2.30e-06 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 52.36 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 952 GRSQRQASPVQTHPKSRQMSRTLERSGTVVSRVGHGRSLGSQARRAAGKPQP-EKACAQGLQLTKAAGKSIRTLPHIKYP 1030
Cdd:PHA03377 544 GRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTgPRQQAKCKDGPPASGPHEKQPPSSAPR 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1031 HPQPCQPAGASQERIMPvshqgaqQTTQGRPADF-AFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPF-------- 1101
Cdd:PHA03377 624 DMAPSVVRMFLRERLLE-------QSTGPKPKSFwEMRAGRDGSGIQQEPSSRRQPATQSTPPRPSWLPSVFvlpsvdag 696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1102 QPVPSQKKPSHS----RPS--QAKPPHLDPSHANLTQGQPSQATPTHSQA---SQAKPTHSQAnshhPHPSHAKP----- 1167
Cdd:PHA03377 697 RAQPSEESHLSSmsptQPIshEEQPRYEDPDDPLDLSLHPDQAPPPSHQApysGHEEPQAQQA----PYPGYWEPrppqa 772
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1168 --------------SHQNPSHANPTHPQSSHAKPSHP---QSSHAKPSHPQSSHA-KPSHPQ---SSHAKPSHPQSSQAK 1226
Cdd:PHA03377 773 pylgyqepqaqgvqVSSYPGYAGPWGLRAQHPRYRHSwayWSQYPGHGHPQGPWApRPPHLPpqwDGSAGHGQDQVSQFP 852
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1907112372 1227 PSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSP 1279
Cdd:PHA03377 853 HLQSETGPPRLQLSQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIPTRFPPPP 905
|
|
| CARD_NOD2_1_CARD15 |
cd08787 |
Caspase activation and recruitment domain of NOD2, repeat 1; Caspase activation and ... |
161-238 |
2.45e-06 |
|
Caspase activation and recruitment domain of NOD2, repeat 1; Caspase activation and recruitment domain (CARD) similar to that found in human NOD2 (CARD15), repeat 1. NOD2 is a member of the Nod-like receptor (NLR) family, which plays a central role in the innate immune response. NLRs typically contain an N-terminal effector domain, a central nucleotide-binding domain and a C-terminal ligand-binding region of several leucine-rich repeats (LRRs). In NOD2, as well as NOD1, the N-terminal effector domain is a CARD. NOD2 contains two N-terminal CARD repeats. Mutations in NOD2 have been associated with Crohns disease and Blau syndrome. Nod2-CARDs have been shown to interact with the CARD domain of the downstream effector RICK (RIP2, CARDIAK), a serine/threonine kinase. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 176765 Cd Length: 87 Bit Score: 46.83 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 161 IEKKRTKLLSVL----QQDP-DSILDTLTSRSLISEKEYETLEEITDPL-KKSRKLLILIQKKGEDSCRRFLRCLSNAFP 234
Cdd:cd08787 1 FLAQRSELLEVLcsggSLEPfESVLDWLLSQEVLSWEDYEGFHVLGQPLsHNARQLLDTVYNKGEWACQKFLAAAQQALA 80
|
....
gi 1907112372 235 ESAS 238
Cdd:cd08787 81 EEQS 84
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1097-1287 |
3.61e-06 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 51.62 E-value: 3.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1097 QPQPFQPVPSQKKPS--HSRPSQaKPPHLDPSHANLTQGQPSQATPTHSQASQAkpthsqANSHHPHPSHAKPSHQNPSH 1174
Cdd:PRK10263 376 APEGYPQQSQYAQPAvqYNEPLQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQP------AQQPYYAPAPEQPVAGNAWQ 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1175 ANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHP-----QSSQAKPTHPQSSQANSHH 1249
Cdd:PRK10263 449 AEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPplyyfEEVEEKRAREREQLAAWYQ 528
|
170 180 190
....*....|....*....|....*....|....*...
gi 1907112372 1250 PQASQAKPSHPqsshAKPSHPHPSHAKPSPSQSTQCKA 1287
Cdd:PRK10263 529 PIPEPVKEPEP----IKSSLKAPSVAAVPPVEAAAAVS 562
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
1116-1323 |
4.11e-06 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 51.61 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1116 SQAKPPHLDPSHANLTQGQPSQaTPTHSQASQaKPTHSQANSHHPHPSHAKPSHQNPS--------HANPTHPQSSHAKP 1187
Cdd:PTZ00395 303 NNTNDAQRNAIQGDLVRGAPND-KNSFDRGNE-KTYQIYGGFHDGSPNAASAGAPFNGlgnqadggHINQVHPDARGAWA 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1188 SHPQS----SHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAkpthPQSSQANSHHPQASQAKPSHPQS- 1262
Cdd:PTZ00395 381 GGPHSnasyNCAAYSNAAQSNAAQSNAGFSNAGYSNPGNSNPGYNNAPNSNT----PYNNPPNSNTPYSNPPNSNPPYSn 456
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907112372 1263 ---SHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPfQPRPTQPKSSKtkpSQARAFHPRAG 1323
Cdd:PTZ00395 457 lpySNTPYSNAPLSNAPPSSAKDHHSAYHAAYQHRAAN-QPAANLPTANQ---PAANNFHGAAG 516
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
1164-1320 |
6.22e-06 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 50.80 E-value: 6.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1164 HAKPSHQNP----SHANPTHPQSSHAKPSHPQSSHAKPSHPQSS--------------HAKPS----HPQSSHAKPSHPQ 1221
Cdd:pfam09770 99 QVRFNRQQPaaraAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykepepipdlQVDASlwgvAPKKAAAPAPAPQ 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1222 SSQAKPSHPQSS---------------QAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKP-SHPHPSHAKPSPSQSTQC 1285
Cdd:pfam09770 179 PAAQPASLPAPSrkmmsleeveaamraQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQiQQQQQPQQQPQQPQQHPG 258
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907112372 1286 KAHKAHQSQ-PKPFQPRPTQPKSSKTKPSQARAFHP 1320
Cdd:pfam09770 259 QGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPP 294
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
862-1319 |
7.16e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.71 E-value: 7.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 862 PYPAHPWPLPIEAGSNFYHVPLRAPRAISSHFRSQQKAewffPFPHQNTSVHSRGqnfaiKYLQPWRFYSRERFTRCSAT 941
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV----PPPERPRDDPAPG-----RVSRPRRARRLGRAAQASSP 2679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 942 PQQYHPN------GPFGRSQRQASPVQThPKSRQMSRTLERSGTVVSRVGHGRSLGSQARRAAgKPQPEKACAQGLQLTK 1015
Cdd:PHA03247 2680 PQRPRRRaarptvGSLTSLADPPPPPPT-PEPAPHALVSATPLPPGPAAARQASPALPAAPAP-PAVPAGPATPGGPARP 2757
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1016 AAGKSIRTLPHikyPHPqPCQPAGASQERIMPVSHQGAQQTTQGRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKH 1095
Cdd:PHA03247 2758 ARPPTTAGPPA---PAP-PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1096 FQPQPfQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQ-ATPTHSQASQ-AKPTHSQANSHHPHPSHAKPSHQNPS 1173
Cdd:PHA03247 2834 AQPTA-PPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKpAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQPQ 2912
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1174 HANPTHPQSSHAKPSHPQSSHAKPSHPQSshakPSHPQSSHAKPSHPQSSQAKPSH---------------PQSSQAKPT 1238
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavprfrvPQPAPSREA 2988
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1239 HPQSSQANSHHPQ----------ASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSS 1308
Cdd:PHA03247 2989 PASSTPPLTGHSLsrvsswasslALHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAH 3068
|
490
....*....|.
gi 1907112372 1309 KTKPSQARAFH 1319
Cdd:PHA03247 3069 EPDPATPEAGA 3079
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1020-1267 |
1.93e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1020 SIRTLPHIKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPA--------DFAFKPGSQSTSGSKLSSTSQSSAHQPKF 1091
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAaparppvrRLARPAVSRSTESFALPPDQPERPPQPQA 2913
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1092 QSKHfQPQPFQPVPSQKKPSHSRPSQAKPPhLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQN 1171
Cdd:PHA03247 2914 PPPP-QPQPQPPPPPQPQPPPPPPPRPQPP-LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1172 PSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQS--SHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHH 1249
Cdd:PHA03247 2992 STPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDdtEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPD 3071
|
250
....*....|....*...
gi 1907112372 1250 PQASQAKPSHPQSSHAKP 1267
Cdd:PHA03247 3072 PATPEAGARESPSSQFGP 3089
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
1186-1312 |
2.62e-05 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 48.58 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1186 KPSHPQSSHAKPSHP----QSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQ 1261
Cdd:pfam05110 77 KNSVPQTPQEKPDQPffpdKTSGLPPSFHTSSHSQPMGPPSSSSPSVSSSQSQKKSQARTEPAHGGHSSSGSQSSQRSQG 156
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1907112372 1262 SSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKP 1312
Cdd:pfam05110 157 QSRSKGGQESHSSSHHKRQERREDLFSCASLSHSLEELSPLLSSLSSPVKP 207
|
|
| AF-4 |
pfam05110 |
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ... |
1124-1320 |
3.60e-05 |
|
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Pssm-ID: 461550 [Multi-domain] Cd Length: 514 Bit Score: 48.20 E-value: 3.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1124 DPSHANLTqGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQ--NPSHANPTHPQSSHakpsHPQSSHAKPSHPQ 1201
Cdd:pfam05110 66 NKSNQHLV-GIPKNSVPQTPQEKPDQPFFPDKTSGLPPSFHTSSHSQpmGPPSSSSPSVSSSQ----SQKKSQARTEPAH 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1202 SSHAKP-SHPQSSHAKPSHPQSSQAK-PSHPQSSQAKPTHPQSSQANSHhpQASQAKPSHP-QSSHAKPSHPHPS----H 1274
Cdd:pfam05110 141 GGHSSSgSQSSQRSQGQSRSKGGQEShSSSHHKRQERREDLFSCASLSH--SLEELSPLLSsLSSPVKPLSPSHSrqhtG 218
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907112372 1275 AKPSPSQSTQCKAHKAHQSqPKPFQPRPTQPKSSKTKPSQARAFHP 1320
Cdd:pfam05110 219 SKAQNSSDHHGKEYSHSKS-PRDSEAGSHGPESPSTSLLASSSQLS 263
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1190-1308 |
3.65e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 48.54 E-value: 3.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1190 PQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQaKPTHPQSSQANSHHPQASQAKPSHPQsshaKPSH 1269
Cdd:PRK10263 751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQ-QPVAPQPQYQQPQQPVAPQPQYQQPQ----QPVA 825
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1907112372 1270 PHPSHAKPSPSQSTQCKAHKAH-----QSQPKPFQpRPTQPKSS 1308
Cdd:PRK10263 826 PQPQYQQPQQPVAPQPQDTLLHpllmrNGDSRPLH-KPTTPLPS 868
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1107-1280 |
4.04e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 48.16 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1107 QKKPSHSRPSQAKPPHLD-----PSHANLTQGqPSQATPTHSQASQAKPTHSQAnshhphpshakPSHQNPSHANPTHPQ 1181
Cdd:PRK10263 708 QQRYSGEQPAGANPFSLDdfefsPMKALLDDG-PHEPLFTPIVEPVQQPQQPVA-----------PQQQYQQPQQPVAPQ 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1182 SSHAKPSHPqsshAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPthPQSSQANSHHPQASQAKPSHPQ 1261
Cdd:PRK10263 776 PQYQQPQQP----VAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ--PQYQQPQQPVAPQPQDTLLHPL 849
|
170
....*....|....*....
gi 1907112372 1262 SSHAKPSHPHPSHAKPSPS 1280
Cdd:PRK10263 850 LMRNGDSRPLHKPTTPLPS 868
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1130-1321 |
5.18e-05 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 47.76 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1130 LTQGQPSQATPTHSQASQAK--PTHSQANSHHPHPshakPSHQNPSHANPTHPQSSHAKPSHPQSShaKPSHPQSSHAKP 1207
Cdd:PTZ00449 476 ISKIQFTQEIKKLIKKSKKKlaPIEEEDSDKHDEP----PEGPEASGLPPKAPGDKEGEEGEHEDS--KESDEPKEGGKP 549
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1208 SHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQssqanshhpqasqaKPSHPQsshaKPSHPHPSHAKPSPSQSTQCKA 1287
Cdd:PTZ00449 550 GETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPK--------------DPKHPK----DPEEPKKPKRPRSAQRPTRPKS 611
|
170 180 190
....*....|....*....|....*....|....*
gi 1907112372 1288 HKAHQSQPKPFQP-RPTQPKSSKTKPSQARAFHPR 1321
Cdd:PTZ00449 612 PKLPELLDIPKSPkRPESPKSPKRPPPPQRPSSPE 646
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
942-1233 |
6.62e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 47.45 E-value: 6.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 942 PQQYHPNGPFGRSQRQASPVQTHPKSRQMSRTLERSGTVVSRVGHGRSLGSQARRAAGKPQPEKACAQGLQ-LTKAAGKS 1020
Cdd:pfam03154 269 PSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPpREQPLPPA 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1021 IRTLPHIKYPHPQPCQPAGASQERIMP--VSHQGAQQTTQGRPADFAFKPGSQSTSgsklssTSQSSAHQPKFQSKHfQP 1098
Cdd:pfam03154 349 PLSMPHIKPPPTTPIPQLPNPQSHKHPphLSGPSPFQMNSNLPPPPALKPLSSLST------HHPPSAHPPPLQLMP-QS 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1099 QPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPT 1178
Cdd:pfam03154 422 QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVS 501
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 1179 HPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSS 1233
Cdd:pfam03154 502 SSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHASQS 556
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1097-1325 |
1.03e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.98 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1097 QPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQA-----TPTHSQAS-----QAKPTHSQANSHHPHPSHAK 1166
Cdd:PHA03378 552 EPASTEPVHDQLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAqtpwpVPHPSQTPeppttQSHIPETSAPRQWPMPLRPI 631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1167 PSHQNPSHANPTHPQsshAKPSHPQSSHAKPSHPQSSHAKPSHP--QSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQ 1244
Cdd:PHA03378 632 PMRPLRMQPITFNVL---VFPTPHQPPQVEITPYKPTWTQIGHIpyQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA 708
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1245 ANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPRAGR 1324
Cdd:PHA03378 709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQ 788
|
.
gi 1907112372 1325 R 1325
Cdd:PHA03378 789 R 789
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
1025-1169 |
1.22e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 46.57 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1025 PHIKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPADFAFK--PGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQ 1102
Cdd:pfam09770 217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQghPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907112372 1103 PVPSQKKPSHSRPSqakpphldPSHANLTQGQPSQATPTHSQASQakptHSQANSHHPHPSHAKPSH 1169
Cdd:pfam09770 297 VQPTQILQNPNRLS--------AARVGYPQNPQPGVQPAPAHQAH----RQQGSFGRQAPIITHPQQ 351
|
|
| ARG80 |
COG5068 |
Regulator of arginine metabolism and related MADS box-containing transcription factors ... |
1101-1305 |
1.23e-04 |
|
Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];
Pssm-ID: 227400 [Multi-domain] Cd Length: 412 Bit Score: 46.16 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1101 FQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQAT-PTHSQASQAKPTHSQANSHHPHP-SHakpSHQNPShanPT 1178
Cdd:COG5068 161 NAPSDSSEEPSSSASFSVDPNDNNPMGSFQHNGSPQTNFiPLQNPQTQQYQQHSSRKDHPTVPhSN---TNNGRP---PA 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1179 HPQSSHAKPSHPQSSHakPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHpqssQANSHHPQASQAKPS 1258
Cdd:COG5068 235 KFMIPELHSSHSTLDL--PSDFISDSGFPNQSSTSIFPLDSAIIQITPPHLPNNPPQENRH----ELYSNDSSMVSETPP 308
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1907112372 1259 HPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQP 1305
Cdd:COG5068 309 PKNLPNGSPNQSPLNNLSRGNPASPNSIIRENNQVEDESFNGRQGSA 355
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
1131-1302 |
1.86e-04 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 45.97 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1131 TQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQnpsHANPTHPQSSHAKPSHPQ-SSHAKP-SHPQSSHAKPS 1208
Cdd:PRK14086 91 SAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRP---PGLPRQDQLPTARPAYPAyQQRPEPgAWPRAADDYGW 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1209 HPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHP-------HPSHAKPSPSQ 1281
Cdd:PRK14086 168 QQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPepppgagHVHRGGPGPPE 247
|
170 180
....*....|....*....|.
gi 1907112372 1282 STQCKAHKAHQSQPKPFQPRP 1302
Cdd:PRK14086 248 RDDAPVVPIRPSAPGPLAAQP 268
|
|
| ROM1 |
COG5422 |
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
1089-1277 |
2.21e-04 |
|
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];
Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 45.65 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1089 PKFQSKHFQPQPFQPVPSQKKpSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPS-HAKP 1167
Cdd:COG5422 80 PKLFQRRNSAGPITHSPSATS-STSSLNSNDGDQFSPASDSLSFNPSSTQSRKDSGPGDGSPVQKRKNPLLPSSStHGTH 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1168 SHQNPSHANPTHPQSSHAK-PSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQAN 1246
Cdd:COG5422 159 PPIVFTDNNGSHAGAPNARsRKEIPSLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLL 238
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907112372 1247 SHHPQASQAkpsHPQSSHAKPSHPH-----PSHAKP 1277
Cdd:COG5422 239 KRHSGSSGA---SLISSNITPSSSNseamsTSSKRP 271
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1111-1300 |
2.42e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.85 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1111 SHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSSHAKPS-- 1188
Cdd:PRK10263 295 SGNRATQPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVia 374
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1189 ------HPQSSHAKPSHPQSSH-AKPSHPQSSHAKPSHPQSSQAKPSHPQSSQA--------KPTHPQSSQANSHHPQAS 1253
Cdd:PRK10263 375 papegyPQQSQYAQPAVQYNEPlQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPaqqpyyapAPEQPVAGNAWQAEEQQS 454
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1254 --QAKPSH-PQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQP 1300
Cdd:PRK10263 455 tfAPQSTYqTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1097-1317 |
3.06e-04 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 45.14 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1097 QPQPFQPVPSQKKPSHSRPSQAKPPHLDPShanlTQGQPSQATPTHSQASQAKPTHSQANshhPHPSHAKPSHQnpshan 1176
Cdd:NF033839 300 QPSPQPEKKEVKPEPETPKPEVKPQLEKPK----PEVKPQPEKPKPEVKPQLETPKPEVK---PQPEKPKPEVK------ 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1177 pthPQSSHAKPS-HPQSSHAKPS-HPQSSHAKPS-HPQSSHAKPS-HPQSSQAKPS-HPQSSQAKP-THPQSSQANSH-H 1249
Cdd:NF033839 367 ---PQPEKPKPEvKPQPETPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPeVKPQPEKPKPEvK 443
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907112372 1250 PQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKS-SKTKPSQARA 1317
Cdd:NF033839 444 PQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTPNNlSKDKQPSNQA 512
|
|
| CARD_BIRC2_BIRC3 |
cd08329 |
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, ... |
149-229 |
3.80e-04 |
|
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2); Caspase activation and recruitment domain (CARD) similar to those found in Baculoviral IAP repeat (BIR)-containing protein 2 (BIRC2) or cellular Inhibitor of Apoptosis Protein 1 (c-IAP1), and BIRC3 (or c-IAP2). IAPs are anti-apoptotic proteins that contain at least one BIR domain. Most IAPs also contain a C-terminal RING domain. In addition, both BIRC2 and BIRC3 contain a CARD. BIRC2 and BIRC3, through their binding with TRAF (TNF receptor-associated factor) 2, are recruited to TNFR-1/2 signaling complexes, where they regulate caspase-8 activity. They also play important roles in pro-survival NF-kB signaling pathways. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260038 Cd Length: 94 Bit Score: 40.89 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 149 EAMATEGASseLIEKKRTKLL----SVLqqdpdSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRR 224
Cdd:cd08329 1 EEMASDDLS--LIRKNRMALFqhltCVL-----PILDHLLSANVITEQEYDVIKQKTQTPLQARELIDTILVKGNAAAEV 73
|
....*
gi 1907112372 225 FLRCL 229
Cdd:cd08329 74 FRNCL 78
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
1182-1321 |
4.01e-04 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 44.82 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1182 SSHAKPSHPQSSHAKPSHPQSSHAKPShPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQAN--SHHPQASQAKPSH 1259
Cdd:PRK14086 90 PSAGEPAPPPPHARRTSEPELPRPGRR-PYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPepGAWPRAADDYGWQ 168
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907112372 1260 PQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPR 1321
Cdd:PRK14086 169 QQRLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPE 230
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
1131-1313 |
4.33e-04 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 43.90 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1131 TQGQPSQATPTHSQA-----SQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHA 1205
Cdd:PRK11901 62 TEHESQQSSNNAGAEknidlSGSSSLSSGNQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAPPQTPNGQQ 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1206 KPSHPQSSHAKPSHPQS--SQAKPSHPQSSQAKPTHPQSsQANSHHPQASQAKPSHPQSshakpsHPHPSHAKPSPSQST 1283
Cdd:PRK11901 142 RIELPGNISDALSQQQGqvNAASQNAQGNTSTLPTAPAT-VAPSKGAKVPATAETHPTP------PQKPATKKPAVNHHK 214
|
170 180 190
....*....|....*....|....*....|
gi 1907112372 1284 QCKAHKAHQSQPKPFQPRPTQPKSSKTKPS 1313
Cdd:PRK11901 215 TATVAVPPATSGKPKSGAASARALSSAPAS 244
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
1175-1281 |
5.59e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 44.38 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1175 ANPTHPQSSHAKPSHPQSsHAKPSHPQSshAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQ 1254
Cdd:PRK14971 360 AQLTQKGDDASGGRGPKQ-HIKPVFTQP--AAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVP 436
|
90 100
....*....|....*....|....*..
gi 1907112372 1255 AKPSHPQSSHAKPShPHPSHAKPSPSQ 1281
Cdd:PRK14971 437 VNPPSTAPQAVRPA-QFKEEKKIPVSK 462
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1200-1320 |
5.63e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.69 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1200 PQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQssqaKPTHPQSSQANSHHPQASQAKPSHPQsshaKPSHPHPSHAKPSp 1279
Cdd:PRK10263 751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ----QPVAPQPQYQQPQQPVAPQPQYQQPQ----QPVAPQPQYQQPQ- 821
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1907112372 1280 sqstqckahkahqsQPKPFQPRPTQPKSSKTKPSQARAFHP 1320
Cdd:PRK10263 822 --------------QPVAPQPQYQQPQQPVAPQPQDTLLHP 848
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
1179-1317 |
6.10e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 44.09 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1179 HPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPS 1258
Cdd:PRK07994 360 HPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAK 439
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907112372 1259 HPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQP----KSSKTKPSQARA 1317
Cdd:PRK07994 440 KSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPvevkKEPVATPKALKK 502
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
1111-1244 |
6.23e-04 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 43.95 E-value: 6.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1111 SHSRPSQAKPPHLDPSHANLTQGQPSQA-TPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPShanpthpqsshakpsh 1189
Cdd:PHA03269 46 PHQAASRAPDPAVAPTSAASRKPDLAQApTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPK---------------- 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 1190 PQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPqssqakPSHPQSSQAKPTHPQSSQ 1244
Cdd:PHA03269 110 PDAAEAFTSAAQAHEAPADAGTSAASKKPDP------AAHTQHSPPPFAYTRSME 158
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1158-1320 |
6.78e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.31 E-value: 6.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1158 HHPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKP 1237
Cdd:PRK10263 367 QTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNA 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1238 THPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARA 1317
Cdd:PRK10263 447 WQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAW 526
|
...
gi 1907112372 1318 FHP 1320
Cdd:PRK10263 527 YQP 529
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1106-1320 |
8.33e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.91 E-value: 8.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1106 SQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQaTPTHSQasqaKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSsha 1185
Cdd:PTZ00449 540 SDEPKEGGKPGETKEGEVGKKPGPAKEHKPSK-IPTLSK----KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKS--- 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1186 kPSHPQS-----SHAKPSHPQSSHAKPShPQSShAKPSHPQSSQA-KPSHPQSSQAKPTHPQSSQA--NSHHPQASQAKP 1257
Cdd:PTZ00449 612 -PKLPELldipkSPKRPESPKSPKRPPP-PQRP-SSPERPEGPKIiKSPKPPKSPKPPFDPKFKEKfyDDYLDAAAKSKE 688
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907112372 1258 ShpqsshakPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQP-RPTQPKSSKTKPSQARAFHP 1320
Cdd:PTZ00449 689 T--------KTTVVLDESFESILKETLPETPGTPFTTPRPLPPkLPRDEEFPFEPIGDPDAEQP 744
|
|
| Metaviral_G |
pfam09595 |
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ... |
1176-1290 |
9.46e-04 |
|
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.
Pssm-ID: 462833 [Multi-domain] Cd Length: 183 Bit Score: 41.86 E-value: 9.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1176 NPTHPQSSHAKPSHPQSShAKPSHPQSSHAKPSHPQSSHakpSHPQSSQAKPSHPQS----SQAKPTHPQSSQANSHHPQ 1251
Cdd:pfam09595 56 NKQHPEQEHHENPPLNEA-AKEAPSESEDAPDIDPNNQH---PSQDRSEAPPLEPAAktkpSEHEPANPPDASNRLSPPD 131
|
90 100 110
....*....|....*....|....*....|....*....
gi 1907112372 1252 ASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKA 1290
Cdd:pfam09595 132 ASTAAIREARTFRKPSTGKRNNPSSAQSDQSPPRANHEA 170
|
|
| ROM1 |
COG5422 |
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
1089-1320 |
1.06e-03 |
|
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];
Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 43.73 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1089 PKFQSKhfQPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKP---THSQANSHHPHPSHA 1165
Cdd:COG5422 24 DAFVSK--QLLPPRRLQRKLNPISIRNGADNDIINSESKESFGKYALGHQIFSSFSSSPKLFqrrNSAGPITHSPSATSS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1166 KPS-------HQNPSHA----NPTHPQSS------HAKPSHPQSSHAKPSHPQSSHAKP---SHPQSSHAKPSHPQSSQA 1225
Cdd:COG5422 102 TSSlnsndgdQFSPASDslsfNPSSTQSRkdsgpgDGSPVQKRKNPLLPSSSTHGTHPPivfTDNNGSHAGAPNARSRKE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1226 KPSH-PQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQ 1304
Cdd:COG5422 182 IPSLgSQSMQLPSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLISSNITPSSSNS 261
|
250
....*....|....*.
gi 1907112372 1305 PKSSKTkpSQARAFHP 1320
Cdd:COG5422 262 EAMSTS--SKRPYIYP 275
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1197-1325 |
1.11e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.52 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1197 PSHPQSSHAKPSHPQSSHAKPSHPQSSqaKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAK 1276
Cdd:PTZ00449 511 PEGPEASGLPPKAPGDKEGEEGEHEDS--KESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHP 588
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1907112372 1277 PSPSQSTQCKAHKAHQSQPKPfqPRPTQPKSSKTKPSQARAFHPRAGRR 1325
Cdd:PTZ00449 589 KDPEEPKKPKRPRSAQRPTRP--KSPKLPELLDIPKSPKRPESPKSPKR 635
|
|
| KLF1_2_4_N-like |
cd22056 |
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ... |
1161-1274 |
1.43e-03 |
|
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.
Pssm-ID: 409231 [Multi-domain] Cd Length: 339 Bit Score: 42.34 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1161 HPSHAKPSHQnpshANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAkPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHP 1240
Cdd:cd22056 203 FMGQQKPKHQ----MHSVHPQAFTHHQAAGPGALQGRGGRGGPDC-HLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAP 277
|
90 100 110
....*....|....*....|....*....|....
gi 1907112372 1241 QSSQANSHHPQASQAKPSHPQSSHAKPShPHPSH 1274
Cdd:cd22056 278 QFHGQYSVFREPMRVHHQGHPGSMLTPP-SSPPL 310
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
1115-1317 |
1.49e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 42.99 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1115 PSQAKPPHlDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQN---PSHANPTHPQSSHAKPShPQ 1191
Cdd:PLN03209 324 PSQRVPPK-ESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDlkpPTSPIPTPPSSSPASSK-SV 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1192 SSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAK---PTHPQSSQANSHHPQASQAkPSHPQSSHAKPS 1268
Cdd:PLN03209 402 DAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDlkpPTSPSPTAPTGVSPSVSST-SSVPAVPDTAPA 480
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1907112372 1269 HPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARA 1317
Cdd:PLN03209 481 TAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEV 529
|
|
| KLF1_2_4_N-like |
cd22056 |
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ... |
1117-1223 |
1.55e-03 |
|
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.
Pssm-ID: 409231 [Multi-domain] Cd Length: 339 Bit Score: 42.34 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1117 QAKPPHLDPSHANLTQGQPSQATPTHSQASQA--KPTHSQANSHHPHPSHakPSHQNPSHANPTHPQssHAKPSHPQ--- 1191
Cdd:cd22056 206 QQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGrgGPDCHLLHSSHHHHHH--HHLQYQYMNAPYPPH--YAHQGAPQfhg 281
|
90 100 110
....*....|....*....|....*....|....
gi 1907112372 1192 --SSHAKPSHPQSSHakpsHPQSSHAKPSHPQSS 1223
Cdd:cd22056 282 qySVFREPMRVHHQG----HPGSMLTPPSSPPLL 311
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1170-1324 |
1.84e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.83 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1170 QNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPsHPQSSQAKPTHPQssQANSHH 1249
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP-HTLIQQTPTLHPQ--RLPSPH 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907112372 1250 PQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKA---HKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHPRAGR 1324
Cdd:pfam03154 247 PPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTgpsHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1030-1244 |
2.31e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1030 PHPQPCQPAGASQErimpvshqgaqqtTQGRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKK 1109
Cdd:PRK07764 590 PAPGAAGGEGPPAP-------------ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKH 656
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1110 PSHSRPSQAKpphlDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSSHAKPSH 1189
Cdd:PRK07764 657 VAVPDASDGG----DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS 732
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1907112372 1190 PQSSHAKPSHPqsshAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQ 1244
Cdd:PRK07764 733 PAADDPVPLPP----EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
1181-1320 |
2.82e-03 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 41.59 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1181 QSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHP---------QSSQANsHHPQ 1251
Cdd:PRK11901 87 LSSGNQSSPSAANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVN-AASQ 165
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907112372 1252 ASQAKPSH--------PQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPRPTQPKSSKTKPSQARAFHP 1320
Cdd:PRK11901 166 NAQGNTSTlptapatvAPSKGAKVPATAETHPTPPQKPATKKPAVNHHKTATVAVPPATSGKPKSGAASARALSSAP 242
|
|
| KLF1_2_4_N-like |
cd22056 |
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ... |
1204-1302 |
2.96e-03 |
|
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.
Pssm-ID: 409231 [Multi-domain] Cd Length: 339 Bit Score: 41.57 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1204 HAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQasqakPSHPQSSHAKPSHPHPSHAKPSPSQ-- 1281
Cdd:cd22056 206 QQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHH-----HHHHLQYQYMNAPYPPHYAHQGAPQfh 280
|
90 100
....*....|....*....|....
gi 1907112372 1282 ---STQCKAHKAHQSQPKPFQPRP 1302
Cdd:cd22056 281 gqySVFREPMRVHHQGHPGSMLTP 304
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1210-1325 |
3.08e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.01 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1210 PQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSqSTQCKAHK 1289
Cdd:PRK14951 373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA-AVALAPAP 451
|
90 100 110
....*....|....*....|....*....|....*..
gi 1907112372 1290 AHQSQPKPFQ-PRPTQPKSSKTKPSQARAFHPRAGRR 1325
Cdd:PRK14951 452 PAQAAPETVAiPVRVAPEPAVASAAPAPAAAPAAARL 488
|
|
| CARD_NOD1_CARD4 |
cd08324 |
Caspase activation and recruitment domain similar to that found in NOD1; Caspase activation ... |
179-229 |
3.23e-03 |
|
Caspase activation and recruitment domain similar to that found in NOD1; Caspase activation and recruitment domain (CARD) found in human NOD1 (CARD4) and similar proteins. NOD1 is a member of the Nod-like receptor (NLR) family, which plays a central role in the innate immune response. NLRs typically contain an N-terminal effector domain, a central nucleotide-binding domain and a C-terminal ligand-binding region of several leucine-rich repeats (LRRs). In NOD1, as well as NOD2, the N-terminal effector domain is a CARD. Nod1-CARD has been shown to interact with the CARD domain of the downstream effector RICK (RIP2, CARDIAK), a serine/threonine kinase. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260035 Cd Length: 85 Bit Score: 37.84 E-value: 3.23e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1907112372 179 ILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCL 229
Cdd:cd08324 20 LLDNLLKNGYFSTEDAEIVQRCPTQTDKVRKILDLVQSKGEEVSEFFIYIL 70
|
|
| PHA02666 |
PHA02666 |
hypothetical protein; Provisional |
1107-1278 |
3.35e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 222914 [Multi-domain] Cd Length: 287 Bit Score: 41.07 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1107 QKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHPQSSHAK 1186
Cdd:PHA02666 43 KSRPSRQHRSAERTPTTASSLTHENNTAPSRHGKQHSCKASSRSSHNRGSTSSSHNHHAHRGPHQSAHRRSKHDAVRDTY 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1187 PSHPQSshakPSHPQSSHAKPSHPQSSHAKPSH----PQSSQAKPSHPQSSQAKPthpqssqaNSHHPQASQAKPSHPQS 1262
Cdd:PHA02666 123 QPCPQS----PETDLYKGRLPGETERHYETPDHiydvPEDVRCAAVEPRRDLALP--------PLHIPSSKPARRMRPGS 190
|
170
....*....|....*.
gi 1907112372 1263 SHAKPSHpHPSHAKPS 1278
Cdd:PHA02666 191 MGDFPMK-HTSAGKPN 205
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1015-1201 |
3.84e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1015 KAAGKSIRTLPHIKYPHPQPCQPAGASQERIMPVSHQGAQQTTQGRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSK 1094
Cdd:PRK07764 593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK 672
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1095 HFQPQPFQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPS-HQNPS 1173
Cdd:PRK07764 673 AGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDdPPDPA 752
|
170 180
....*....|....*....|....*...
gi 1907112372 1174 HANPTHPQSSHAKPSHPQSSHAKPSHPQ 1201
Cdd:PRK07764 753 GAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
1062-1244 |
3.86e-03 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 41.98 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1062 ADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKKPsHSRPSQAKPPhldpsHANLTQGQPSQATPT 1141
Cdd:PTZ00395 395 SNAAQSNAAQSNAGFSNAGYSNPGNSNPGYNNAPNSNTPYNNPPNSNTP-YSNPPNSNPP-----YSNLPYSNTPYSNAP 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1142 HSQASQAKPThsqansHHPHPSHAKPSHQN---PSHANPTHPQSShAKPSH--PQSSHAKP--SHPQSSHAKPSHPQSSh 1214
Cdd:PTZ00395 469 LSNAPPSSAK------DHHSAYHAAYQHRAanqPAANLPTANQPA-ANNFHgaAGNSVGNPfaSRPFGSAPYGGNAATT- 540
|
170 180 190
....*....|....*....|....*....|
gi 1907112372 1215 akpSHPQSSQAKPSHPQSSQAKPTHPQSSQ 1244
Cdd:PTZ00395 541 ---ADPNGIAKREDHPEGGTNRQKYEQSDE 567
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
1086-1305 |
3.87e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.45 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1086 AHQPKFQSKHFQPQPFQPVPSQKKPShsRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHhPHPSHA 1165
Cdd:PLN03209 336 ADGPKPVPTKPVTPEAPSPPIEEEPP--QPKAVVPRPLSPYTAYEDLKPPTSPIPTPPSSSPASSKSVDAVAK-PAEPDV 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1166 KPSHQNPSHANPTHPQSSHAKPSHPQSSHA-----KPshpqsshakPSHPQSSHAKPSHPQSSQAkPSHPQSSQAKPthP 1240
Cdd:PLN03209 413 VPSPGSASNVPEVEPAQVEAKKTRPLSPYAryedlKP---------PTSPSPTAPTGVSPSVSST-SSVPAVPDTAP--A 480
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1241 QSSQANSHHPQA------------SQAKPSHPQSSHAKPSHPHPSHAKPSPSQST---QCKAHKAHQSQPKpfqPRPTQP 1305
Cdd:PLN03209 481 TAATDAAAPPPAnmrplspyavydDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSappTALADEQHHAQPK---PRPLSP 557
|
|
| ARG80 |
COG5068 |
Regulator of arginine metabolism and related MADS box-containing transcription factors ... |
1032-1280 |
4.20e-03 |
|
Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];
Pssm-ID: 227400 [Multi-domain] Cd Length: 412 Bit Score: 41.15 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1032 PQPCQPAGASQERIMPVSHQGAQQTTQGRPADFAFKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQPFQPVPSQKKPS 1111
Cdd:COG5068 144 SVVKSLEGKSLIQSPCSNAPSDSSEEPSSSASFSVDPNDNNPMGSFQHNGSPQTNFIPLQNPQTQQYQQHSSRKDHPTVP 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1112 HSRPSQAKPPHLdPSHANLTQGQPSQATPTHSQASQAKPTHSQAnshhphpSHAKPSHQNPSHANPTHPQSSHAKPSHPQ 1191
Cdd:COG5068 224 HSNTNNGRPPAK-FMIPELHSSHSTLDLPSDFISDSGFPNQSST-------SIFPLDSAIIQITPPHLPNNPPQENRHEL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1192 SSHakPSHPQSSHAKPshPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPH 1271
Cdd:COG5068 296 YSN--DSSMVSETPPP--KNLPNGSPNQSPLNNLSRGNPASPNSIIRENNQVEDESFNGRQGSAIWNALISTTQPNSGLH 371
|
....*....
gi 1907112372 1272 PSHAKPSPS 1280
Cdd:COG5068 372 TEASTAPSS 380
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
1105-1295 |
4.32e-03 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 40.82 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1105 PSQKKPSHSRPSQ--AKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANShhPHPSHAKPSHQNPSHANPTHPQS 1182
Cdd:PRK11901 61 PTEHESQQSSNNAgaEKNIDLSGSSSLSSGNQSSPSAANNTSDGHDASGVKNTAP--PQDISAPPISPTPTQAAPPQTPN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1183 SHAKPSHPQSSHAKPSHPQSshakpshpQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSH---HPQASQAKPsh 1259
Cdd:PRK11901 139 GQQRIELPGNISDALSQQQG--------QVNAASQNAQGNTSTLPTAPATVAPSKGAKVPATAETHptpPQKPATKKP-- 208
|
170 180 190
....*....|....*....|....*....|....*.
gi 1907112372 1260 PQSSHAKPSHPHPSHAKPSPSQSTqcKAHKAHQSQP 1295
Cdd:PRK11901 209 AVNHHKTATVAVPPATSGKPKSGA--ASARALSSAP 242
|
|
| Pneumo_att_G |
pfam05539 |
Pneumovirinae attachment membrane glycoprotein G; |
1143-1313 |
4.73e-03 |
|
Pneumovirinae attachment membrane glycoprotein G;
Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 41.19 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1143 SQASQAKPTHSQANSHHPhpshAKPSHQNP-SHANPTHPQSSHAKpshpQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQ 1221
Cdd:pfam05539 170 TAVTTSKTTSWPTEVSHP----TYPSQVTPqSQPATQGHQTATAN----QRLSSTEPVGTQGTTTSSNPEPQTEPPPSQR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1222 SSQAKPSHPQSsqakpTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHPSHAKPSPSQSTQCKAHKAHQSQPKPFQPR 1301
Cdd:pfam05539 242 GPSGSPQHPPS-----TTSQDQSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPP 316
|
170
....*....|..
gi 1907112372 1302 PTQPKSSKTKPS 1313
Cdd:pfam05539 317 HSSPPGVQANPT 328
|
|
| KLF1_2_4_N-like |
cd22056 |
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ... |
1158-1264 |
5.08e-03 |
|
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.
Pssm-ID: 409231 [Multi-domain] Cd Length: 339 Bit Score: 40.80 E-value: 5.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1158 HHPHPSHAKPSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHakpsHPQSSHAKPSHPQSSQAKPSHPQ-----S 1232
Cdd:cd22056 209 PKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHH----HHLQYQYMNAPYPPHYAHQGAPQfhgqyS 284
|
90 100 110
....*....|....*....|....*....|..
gi 1907112372 1233 SQAKPTHPQssqaNSHHPQASQAKPSHPQSSH 1264
Cdd:cd22056 285 VFREPMRVH----HQGHPGSMLTPPSSPPLLE 312
|
|
| PRK14949 |
PRK14949 |
DNA polymerase III subunits gamma and tau; Provisional |
1106-1264 |
6.34e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237863 [Multi-domain] Cd Length: 944 Bit Score: 40.86 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1106 SQKKPSHSR----PSQAKPPhLDPSHANltqgqpSQATPTHSQASQAKPTHSQANSHHPHPSHAKPSHQNPSHANPTHP- 1180
Cdd:PRK14949 635 DGKKSSADRkpktPPSRAPP-ASLSKPA------SSPDASQTSASFDLDPDFELATHQSVPEAALASGSAPAPPPVPDPy 707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1181 -------QSSHAKPSHPQSSHAKPSHPQSSH-AKPSHPQSSHAKPSHPQSSQAKPshpQSSQAKPTHPQSSQANSHHPQA 1252
Cdd:PRK14949 708 drppweeAPEVASANDGPNNAAEGNLSESVEdASNSELQAVEQQATHQPQVQAEA---QSPASTTALTQTSSEVQDTELN 784
|
170
....*....|..
gi 1907112372 1253 SQAKPSHPQSSH 1264
Cdd:PRK14949 785 LVLLSSGSITGH 796
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1028-1213 |
6.97e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.84 E-value: 6.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1028 KYPHPQPCQPAGASQERIMPVSHQGA---QQTTQG-RPA--------DFAFKP-------GSQSTSGSKLSSTSQSSAHQ 1088
Cdd:PRK10263 679 QYQHDVPVNAEDADAAAEAELARQFAqtqQQRYSGeQPAganpfsldDFEFSPmkallddGPHEPLFTPIVEPVQQPQQP 758
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1089 PKFQSKHFQPQpfQPVPSQKKpsHSRPSQAKPPhldpSHANLTQGQPSQATPTHSQASQakPTHSQANSHHPH-PSHAKP 1167
Cdd:PRK10263 759 VAPQQQYQQPQ--QPVAPQPQ--YQQPQQPVAP----QPQYQQPQQPVAPQPQYQQPQQ--PVAPQPQYQQPQqPVAPQP 828
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1907112372 1168 SHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHpqsshaKPSHPQSS 1213
Cdd:PRK10263 829 QYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLH------KPTTPLPS 868
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
994-1246 |
7.15e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.84 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 994 ARRAAGKPQPEKACAQGLQLTKAagkSIRTLPHIKYPHPQPCQPAGASQE--------RIMPVSHQGAQQTTQGRPADFA 1065
Cdd:PRK10263 349 VDVPPAQPTVAWQPVPGPQTGEP---VIAPAPEGYPQQSQYAQPAVQYNEplqqpvqpQQPYYAPAAEQPAQQPYYAPAP 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1066 FKPGSQSTSGSKLSSTSQSSAHQPKFQSKHFQPQP-FQPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQPSQATPTHS- 1143
Cdd:PRK10263 426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQStYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPp 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1144 -------QASQAKPTHSQANSHHPHPSHAK-PSHQNPSHANPTHPQSSHAKPSHPQSSHAKPSHPQSSHAkpshpqSSHA 1215
Cdd:PRK10263 506 lyyfeevEEKRAREREQLAAWYQPIPEPVKePEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT------GAAA 579
|
250 260 270
....*....|....*....|....*....|.
gi 1907112372 1216 KPSHPQSSQAKPSHPQSSQAKPTHPQSSQAN 1246
Cdd:PRK10263 580 TVAAPVFSLANSGGPRPQVKEGIGPQLPRPK 610
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1116-1314 |
7.65e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.84 E-value: 7.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1116 SQAKPPHLDpSHANLTQGQPSQA---------TPTHSQASQAKPTHSQANSHHPHPSHAKPS--------HQNPSHANPT 1178
Cdd:PRK10263 297 NRATQPEYD-EYDPLLNGAPITEpvavaaaatTATQSWAAPVEPVTQTPPVASVDVPPAQPTvawqpvpgPQTGEPVIAP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1179 HPQS--SHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQaSQAK 1256
Cdd:PRK10263 376 APEGypQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-EQQS 454
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907112372 1257 PSHPQSSHaKPSHPHPSHAKPSPSqstqckaHKAHQSQPKPFQPRPtQPKSSKTKPSQ 1314
Cdd:PRK10263 455 TFAPQSTY-QTEQTYQQPAAQEPL-------YQQPQPVEQQPVVEP-EPVVEETKPAR 503
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1113-1320 |
8.76e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.45 E-value: 8.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1113 SRPSQAKPPHLDPSHANLTQGQPSQATPTHSQASQAKPTHSQANSHHPHPSHAKPShqNPSHANPTHPqSSHAKPSHPQS 1192
Cdd:PRK10263 282 ARGVAADPDDVLFSGNRATQPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPV--EPVTQTPPVA-SVDVPPAQPTV 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1193 SHAKPSHPQSshAKPSHPQSSHAKPSHPQSSQakpshPQSSQAKPTHPQSSQANSHHPQASQAKPSHPQSSHAKPSHPHP 1272
Cdd:PRK10263 359 AWQPVPGPQT--GEPVIAPAPEGYPQQSQYAQ-----PAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1273 SHAKPSPSQSTQCKAHKAHQSQPkPFQPRPT-QPKSSKTKP-SQARAFHP 1320
Cdd:PRK10263 432 PYYAPAPEQPVAGNAWQAEEQQS-TFAPQSTyQTEQTYQQPaAQEPLYQQ 480
|
|
| PRK10905 |
PRK10905 |
cell division protein DamX; Validated |
1102-1282 |
9.48e-03 |
|
cell division protein DamX; Validated
Pssm-ID: 236792 [Multi-domain] Cd Length: 328 Bit Score: 39.92 E-value: 9.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1102 QPVPSQKKPSHSRPSQAKPPHLDPSHANLTQGQpsqaTPTHSQASQAKPTHSQANShhphpshAKPSHQNPSHAN----- 1176
Cdd:PRK10905 52 QPAPGTTSAEQTAGNTQQDVSLPPISSTPTQGQ----TPVATDGQQRVEVQGDLNN-------ALTQPQNQQQLNnvavn 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907112372 1177 ---PTHPqSSHAKPSHPQSSHAKPSHPQSSHAKPSHPQSSHA--KPSHPQSSQAKPSHPQSSQAKPTHPQSSQANSHHPQ 1251
Cdd:PRK10905 121 stlPTEP-ATVAPVRNGNASRQTAKTQTAERPATTRPARKQAviEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPA 199
|
170 180 190
....*....|....*....|....*....|.
gi 1907112372 1252 ASQAKPSHPQSSHAKPSHPHPSHAKPSPSQS 1282
Cdd:PRK10905 200 ATSTPAPKETATTAPVQTASPAQTTATPAAG 230
|
|
| CARD_RIP2_CARD3 |
cd08786 |
Caspase activation and recruitment domain of Receptor Interacting Protein 2; Caspase ... |
159-229 |
9.57e-03 |
|
Caspase activation and recruitment domain of Receptor Interacting Protein 2; Caspase activation and recruitment domain (CARD) of Receptor Interacting Protein 2 (RIP2/RIPK2/RICK/CARDIAK/CARD3). RIP kinases serve as essential sensors of cellular stress. Vertebrates contain several types containing a homologous N-terminal kinase domain and varying C-terminal domains. RIP2 harbors a C-terminal CARD domain and functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR)-family, NOD1 and NOD2, which recognizes bacterial peptidoglycans released upon infection. This cascade is implicated in inflammatory immune responses and the clearance of intracellular pathogens. RIP2 associates with NOD1 and NOD2 via CARD-CARD interactions. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 176764 Cd Length: 87 Bit Score: 36.82 E-value: 9.57e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907112372 159 ELIEKKRTKLLSVLQQDP-DSILDTLTSRSLISEKEYETLEEITDPLKKSRKLLILIQKKGEDSCRRFLRCL 229
Cdd:cd08786 1 QWIASKREEIVSQMTEAClNQSLDALLSRQLLMREDYELISTKPTRTSKVRQLLDTCDCQGEEFARVVVQKL 72
|
|
| |
