|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
37-448 |
1.65e-137 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 400.07 E-value: 1.65e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 37 AFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPtnsqdvwnetlQESKAPVYDWTPEIQGILLSSLSYGS 116
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDT-----------LPVEAPEFDWSEKTQGIILSSFFYGY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 117 FIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLI 196
Cdd:cd17318 70 ILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcslgw 276
Cdd:cd17318 150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 277 slpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 357 RLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGG 436
Cdd:cd17318 269 STTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGI 348
|
410
....*....|..
gi 568981866 437 IAPTVAGFFISQ 448
Cdd:cd17318 349 ISPLIVGAIVKN 360
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
27-448 |
4.47e-120 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 358.29 E-value: 4.47e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 27 KGFCSLRHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDvwnetlqeskaPVYDWTPEIQG 106
Cdd:TIGR00894 11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKN-----------PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 107 ILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKW 186
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 187 APPQERSQLITIAASGSMLGTFLVLIAGGLICQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITC 265
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 266 SLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 346 LADFLLSRKILRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKG 425
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420
....*....|....*....|...
gi 568981866 426 LLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQ 422
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
36-445 |
1.47e-90 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 280.51 E-value: 1.47e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 36 LAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERP-PTNSQDVwnetLQESKAPVYDWTPEIQGILLSSLSY 114
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPeHSSSPSV----EHNETGKKYDWDAETQGWILGSFFY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 115 GSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQ 194
Cdd:cd17381 77 GYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 195 LITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgerryitcslaqedcsl 274
Cdd:cd17381 157 LLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV----------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 275 gwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRK 354
Cdd:cd17381 208 ------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 355 ILRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLA 434
Cdd:cd17381 276 NFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIP 355
|
410
....*....|.
gi 568981866 435 GGIAPTVAGFF 445
Cdd:cd17381 356 GMVGPVIAKSL 366
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
53-448 |
7.90e-60 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 200.26 E-value: 7.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 53 NLSFAITAMV-NTTVASSQLNASTErpptnsqdvwnetlqeskaPVYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFG 131
Cdd:cd17382 17 NLGVAIVRMVnNFTDAYGGKVIVHK-------------------AEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 132 AKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVL 211
Cdd:cd17382 78 ANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 212 IAGGLICQALGWPYIFYIFGGIGCacclLWFplvyddpqnhpfistgerryitcslaqedcsLGWslpikaMVKSLPLWA 291
Cdd:cd17382 158 PLSGILVQYVGWSSPFYVYGVFGI----IWY-------------------------------MFW------MLVSMPVYA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 292 IVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAVGVL 371
Cdd:cd17382 197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFG 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981866 372 ASSGILLPLPWVRsSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:cd17382 277 MEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKH 352
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
98-448 |
2.25e-53 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 182.75 E-value: 2.25e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVLRVIQGMAQVMVLT 177
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfist 257
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 gerryitcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLqANLRDSGILSALPFMFGC 337
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRKIlRLVTIRKLFTAVGVLASSGILLPLPWVrSSRSTTMAFLVLSSVFASLCDSGALINFLDIAP 417
Cdd:cd17380 227 PSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAP 304
|
330 340 350
....*....|....*....|....*....|.
gi 568981866 418 RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:cd17380 305 NYAGIVFGISNTAGTIPGIVGVYLTGYILEA 335
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
98-448 |
2.28e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.97 E-value: 2.28e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPlvyddpqnhpfist 257
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG----LLLAL-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 gerryitcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2271 180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRkilrlvtiRKLFTAVGVLASSGILLPLPWVrSSRSTTMAFLVLSSVFASLCDSGALINFLDIAP 417
Cdd:COG2271 231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALL-PSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350
....*....|....*....|....*....|..
gi 568981866 418 -RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
100-446 |
2.61e-26 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 109.20 E-value: 2.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 100 WTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQ 179
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 180 YSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDdpqnhpfistge 259
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 260 rryitcslaqedcslgwslpikamvkslpLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVC 339
Cdd:cd17319 181 -----------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 340 IILGGLLADFLLSRKILRLVTIRKLFTAVGVLASSgiLLPLPWVrssrstTMAFLVLSSVFASLCDSGALINFLDIAPR- 418
Cdd:cd17319 232 MILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAY--LTTSPVV------AVILLSLAGFGIGAASPVFWSLPADLLPGe 303
|
330 340
....*....|....*....|....*...
gi 568981866 419 YAGFLKGLLQVFSYLAGGIAPTVAGFFI 446
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-439 |
1.04e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.12 E-value: 1.04e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLT 177
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFIST 257
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 GERRYITcslaqedcslgwSLPIKAMVKSLPLWAIVVSyFCEYWLLSTVMAYTPTYIsSVLQANLRDSGILSALPFMFGC 337
Cdd:pfam07690 184 EEARLSL------------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADfllsrkilRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAP 417
Cdd:pfam07690 250 IGRLLLGRLSD--------RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 568981866 418 -RYAGFLKGLLQVFSYLAGGIAP 439
Cdd:pfam07690 322 kEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
97-448 |
2.14e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.49 E-value: 2.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVL 176
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQAL--GWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPF 254
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 255 IStgerryitcslaQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFM 334
Cdd:cd06174 183 KN------------EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 335 FGCVCIILGGLLADFLLSRKILrlvtirklfTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLD 414
Cdd:cd06174 251 AGALGSLLLGLLSDRLIGRKPL---------LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350
....*....|....*....|....*....|....
gi 568981866 415 IAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
106-446 |
2.55e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.09 E-value: 2.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPfistgerryitc 265
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 266 slAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17325 180 --KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 346 LADfllsrKILRLVTIrklftaVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-GFLK 424
Cdd:cd17325 258 LSD-----RIGRKPLI------LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAM 326
|
330 340
....*....|....*....|..
gi 568981866 425 GLLQVFSYLAGGIAPTVAGFFI 446
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLY 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
98-446 |
7.08e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.93 E-value: 7.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIST 257
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 GERRyitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2223 193 ASLR-----------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRKILRLVTIrklFTAVGVLASSGILLPLPWVrssrstTMAFLVLSSVFASLCDSG-ALINFLdIA 416
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVLLIVFA---LMALGLLLLALALGSLWLF------LVLFLLLGLALGGGNGAVfALVPDI-FP 325
|
330 340 350
....*....|....*....|....*....|
gi 568981866 417 PRYAGFLKGLLQVFSYLAGGIAPTVAGFFI 446
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
98-438 |
7.14e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.64 E-value: 7.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLT 177
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 178 GQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVyddPQNHPFIST 257
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PESRPAARA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 GERRyitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGC 337
Cdd:COG2814 195 RLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRKILrlvtirklftaVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAP 417
Cdd:COG2814 258 LGALLAGRLADRFGRRRLL-----------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330 340
....*....|....*....|..
gi 568981866 418 -RYAGFLKGLLQVFSYLAGGIA 438
Cdd:COG2814 327 pEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
106-449 |
1.86e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.59 E-value: 1.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFistgerryitc 265
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 266 slaqedcSLGWSLPIKAMVKSLPLWAIVVSYFCeyWLLSTVMAYtpTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17324 184 -------SLGLLSSLLLLLRNPRLRLAYLITFL--LFGGFFALY--TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 346 LADFLLSRkilrlVTIRKLFTAVGVLASSGILLPLPWvrSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKG 425
Cdd:cd17324 253 LAGRLADR-----GGRRALLIALLLLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340
....*....|....*....|....
gi 568981866 426 LLQVFSYLAGGIAPTVAGFFISQL 449
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHG 349
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
106-447 |
1.89e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.42 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSML-GTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERR--Y 262
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPneE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 263 ITCSLAQ-EDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCII 341
Cdd:TIGR00881 191 PDGDAEKkEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 342 LGGLLADFLLSRKilRLVTirKLFTAVGVLASSGILlplpWVRSSRSTTMAFLVLSSVFASLCDSGALINFL--DIAP-R 418
Cdd:TIGR00881 271 LAGWLSDKLFNGR--RGPL--AVFFMALIIVSLLVY----WLNPAANPLMDLICLFALGFLVYGPQMLIGVIasELAPkK 342
|
330 340
....*....|....*....|....*....
gi 568981866 419 YAGFLKGLLQVFSYLAGGIAPTVAGFFIS 447
Cdd:TIGR00881 343 AAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
118-403 |
4.78e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 70.34 E-value: 4.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLIT 197
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 198 IAASGSMLGTFLVLIAGGLICQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITcslaqedcslGW 276
Cdd:cd17328 127 VFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAT----------SF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 277 SLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKIL 356
Cdd:cd17328 197 LADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRR 276
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 568981866 357 RLVTIRKLFTAVGVLASSGILLPLPWV-RSSRSTTMAFLVLSSVFASL 403
Cdd:cd17328 277 KTPRADPLVCAVGLLAAAPFLFLALVLaLSNLLLAWVLLFLGEFLLSL 324
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
108-382 |
2.18e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 65.35 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 108 LLSSLSYGSFI-APIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAKW 186
Cdd:cd17327 45 WGNTVFYVGYIiFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL--TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 187 APPQERSQLITIAASGSMLGTflvlIAGGLICQAL----------GWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIS 256
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGS----IFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 257 TGERRYITCSLAQEDCSLG-----WSLPIKAMvKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISS----VLQANLrdsgi 327
Cdd:cd17327 199 EEEKELAVERLRANQTGKGdqkfkWKQIKEAF-KDPRTWLLFLFFFCSQITNNGISNFLPLILKSlgfySLQTNL----- 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568981866 328 LSALPFMFGCVCIILGGLLADFLLSRKILrlvtirKLFTAVGVLASSGILLPLPW 382
Cdd:cd17327 273 LSVPIGALGAVSLLIAALLSDRFKKRGLF------AIFACVLALVGSIILLAAPN 321
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
101-352 |
3.62e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.68 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQY 180
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPLVYDDPQNHPFISTGER 260
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG----LLALVLRLRLPESRGLLLALLA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 261 RYITCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCI 340
Cdd:COG0477 201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280
|
250
....*....|..
gi 568981866 341 ILGGLLADFLLS 352
Cdd:COG0477 281 LLLLLLLLLLLA 292
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
106-446 |
3.34e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.41 E-value: 3.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVLTGQYSLwAK 185
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA--PSYPLLLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLV-LIAGGLICQALG--WPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRy 262
Cdd:COG0738 123 ALGPETAASRLNLLHAFFSLGALLGpLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 263 itcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALpFMFGcvcIIL 342
Cdd:COG0738 202 ----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL-FWGG---MTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 343 GGLLADFLLSRkilrlVTIRKLFTAVGVLASSGILLPLPWvrSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGF 422
Cdd:COG0738 262 GRFLGGFLLKR-----FGPVRLLRLSALLAAVGLLLALLA--PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAA 334
|
330 340
....*....|....*....|....
gi 568981866 423 LKGLLQVFSYLAGGIAPTVAGFFI 446
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPLIGFLA 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
138-447 |
3.66e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 3.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 138 LGLLISSVLTLFIPLAADAG----VALLIVLRVIQGMAQVMVLTGQYSLWAKWAP-PQERSQLITIAASGSMLGTFLVLI 212
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 213 AGGLI------CQALGWPYIFYIFGGIGCACCLLwfplvyddpqnhPFISTGERRYITCSlaqedcslgwSLPIKAMVKS 286
Cdd:COG2211 166 LPPPLvaafggDAALGYRLTALIFAVLGLLAFLL------------TFFGTKERPVPEEE----------KVSLKESLKA 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 287 L----PLWAIVVSYFCeYWL-LSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRlvti 361
Cdd:COG2211 224 LlknrPFLLLLLAYLL-FFLaLALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI---- 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 362 rklftaVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFL-DIAP--------RYAGFLKGLLQVFSY 432
Cdd:COG2211 299 ------IGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLaDVVDydewktgrRREGLYFGIFTFAIK 372
|
330
....*....|....*
gi 568981866 433 LAGGIAPTVAGFFIS 447
Cdd:COG2211 373 LGQALAGALAGLLLA 387
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
106-243 |
2.26e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.65 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTlfIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLST--AMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI---FGGIGCACCLLWFP 243
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFlaiLALAAFILLAFLLP 139
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
111-450 |
3.82e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.87 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 111 SLSYGSFIapIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQ 190
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF--LIAARALQGIGAAAIMPASLALIAATFPGE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 191 ERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLwfplvyddpqnhpfistgerryitcslaqe 270
Cdd:cd17321 117 RRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL------------------------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 271 dcslgwslpikamvkSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSaLPFMFGC-VCIILGGLLADF 349
Cdd:cd17321 167 ---------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMlVAAPLAGRLADR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 350 LLSRKILRLVTirkLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLcdSGALINFLDiaPRYAGFLKGLLQV 429
Cdd:cd17321 231 FGPRLVLVAGL---LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPL--TNAALSSVP--KEKAGAASGILNT 303
|
330 340
....*....|....*....|.
gi 568981866 430 FSYLAGGIAPTVAGFFISQLL 450
Cdd:cd17321 304 ARQLGGALGVALLGALLTAGL 324
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
106-448 |
4.07e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.02 E-value: 4.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLtlFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPqnhpfistgERRYITC 265
Cdd:cd17333 112 LFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPEL---------PSARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 266 SLAQEDcslgwSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17333 183 QSVGAF-----SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 346 LADFLLSRKILRLVT-IRKLFTAVGVLASSGILLplpwvrsSRSTTMAFLVLSSVFASlcdsgALINFLDIAPRYAGFLK 424
Cdd:cd17333 258 ISRRIKPHTLLVLSGsGALLGLLILLLAPTLVVG-------LVATALLGLFMAALFPT-----ILSLGISNLPYAKGKGT 325
|
330 340
....*....|....*....|....
gi 568981866 425 GLLQVFSYLAGGIAPTVAGFFISQ 448
Cdd:cd17333 326 SVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
106-447 |
4.60e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 4.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPqnhpfistgeRRYITC 265
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP----------PYVWVL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 266 SLAQedcslgwslpikamvkslpLWAIVVSYFCEYWLlstvmaytPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 345
Cdd:cd17312 189 SLAY-------------------AFVYIVRYACLDWG--------PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 346 LADFLLSRKilRLVTIrkLFTAVGVLASSGILLPLPWVRSSRSTTMaFLVLSSVFASLCDSGALINfLDIAPRYA-GFLK 424
Cdd:cd17312 242 LSDKLFGGR--RAPIA--VIYMLLMTLSLALFWFFPHNKLLSIVLL-FLIGFFVGGPINLIGGAAA-QDIGRKEAaGTAT 315
|
330 340
....*....|....*....|...
gi 568981866 425 GLLQVFSYLAGGIAPTVAGFFIS 447
Cdd:cd17312 316 GFVGLFGYLGASLAGLPLGYIID 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
106-446 |
7.82e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.17 E-value: 7.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVltLFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFyIFGGIGCACCLLWFPLVYDDPQN---HPFISTGERRy 262
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF-VVAGLVSILAAVLFWLFYREPPAasaATESASTLLR- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 263 itcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIIL 342
Cdd:cd17475 190 ----------------SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 343 GGLLADFLLSRKilRLVTIRkLFTAVGVLASSGILLPLPwvrssrSTTMAFLVLSSVFASLCDSG-ALINFLDIA----P 417
Cdd:cd17475 254 LGRVSDRVFGGR--RRPVLV-ITAAIAAAALLVLSLLSP------GTPLWLLVLLLILLGLFAIGwNGLYLTLVAesagP 324
|
330 340
....*....|....*....|....*....
gi 568981866 418 RYAGFLKGLLQVFSYLAGGIAPTVAGFFI 446
Cdd:cd17475 325 EQAGTALGLANTINFIGIAIGPPLFGLLV 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
97-242 |
1.89e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.96 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVL 176
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568981866 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIgCACCLLWF 242
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLF 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
101-244 |
2.16e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQY 180
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981866 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPL 244
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
97-244 |
2.94e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVL 176
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568981866 177 TGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPL 244
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
115-399 |
6.48e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.15 E-value: 6.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 115 GSFIAPIptgyVAGVFGAKYVVGLGLLISSVLTLFIPLAAdaGVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQ 194
Cdd:cd06180 50 GALLASF----LRRRGRARRLIRGGLLLTVLLLAAMALTS--GFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGH 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 195 LITIAASGSMLGTFL--VLIAGGLIcQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRyitcslaqedc 272
Cdd:cd06180 124 LIGLLFAGVGLGIALsgLLVPAGLG-GGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAESA----------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 273 slgwslpikaMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYissvlqanLRDSGILSALPFMFGCVcIILGGLLADFLLS 352
Cdd:cd06180 192 ----------PGLNRPLWRLALAYGLFGFGYIITATFLPLI--------ARETGAGSLLAGLLWSL-FGLAAVPSCFLWG 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 568981866 353 RKILRLVTIRKLFTAVGVLAsSGILLPLPWvrssrsTTMAFLVLSSV 399
Cdd:cd06180 253 ALSDRWGTRRALAANLLVQA-VGVLLPLLS------PGPAGLVLSAV 292
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
97-245 |
8.41e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 8.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGA--KYVVGLGLLISSVLTLFIPLAADAGVALLIVlrVIQGMAQVM 174
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981866 175 VLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLV 245
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
121-240 |
1.27e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 50.27 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 121 IP-TGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQ-VMVLTGQySLWAKWAPPQERSQLITI 198
Cdd:cd17503 48 IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGgVLIPLAQ-TILLRIYPPEKRGAAMGL 124
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 568981866 199 AASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLL 240
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
118-444 |
1.43e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFipLAADAGVALLIVLRVIQGMAqVMVLTGQYSLWAKWAPPQERSQLIT 197
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLL--RSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 198 IAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRyitcslaqedcslgws 277
Cdd:COG2807 145 LYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL---------------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 278 lpiKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSvLQANLRDSGILSALPFMFGCVCIILGGLLADfllsrkilR 357
Cdd:COG2807 209 ---RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLAD--------R 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 358 LVTIRKLFTAVGVLASSGILLPLPWvrsSRSTTMAFLVLSSVFASLCDSGALINFLDIA--PRYAGFLKGLLQVFSYLAG 435
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLLGLLLA---PGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLA 353
|
....*....
gi 568981866 436 GIAPTVAGF 444
Cdd:COG2807 354 ALGPLLVGA 362
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
111-347 |
1.97e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.57 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 111 SLSYGSFIapIPTGYVAGVFGAK--YVVGLGLL-ISSVLTLFIPlaadaGVALLIVLRVIQGMAQVMVLTGQYSLWAK-W 186
Cdd:cd17476 43 SLTVGTFI--LIFGRLGDIYGHKkmFVIGSFWFaIWSLIAGFSP-----NFIFFIICRALQGLGPAFLLPNAMALLGRtY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 187 APPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLwfplvyddpqnHPFISTGERRYITCS 266
Cdd:cd17476 116 PPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA-----------AIFWTSPSFIAVLLA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 267 LAqedcsLGWSlpikamvkSLPLWAIVVSYFCE----YWLLSTVMAYTPTYISSVLqANLRDSGILSALP----FMFGCV 338
Cdd:cd17476 185 VF-----LGWA--------SFGIWVFYATQYFQnvrgYSPLLTSARFIPMAIGGVL-AAITVGFLIARLPpsyiMAISMV 250
|
....*....
gi 568981866 339 CIILGGLLA 347
Cdd:cd17476 251 AFLVGPILF 259
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
121-407 |
3.83e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.79 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 121 IPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAdAGVALLIVLRVIQGMAQVMVLTGQYSLwAKWAPPQERSQLITIAA 200
Cdd:cd17341 52 LPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV-SSYWGLLVLGFLLGFAGANFASGQPWA-SFWFPKEKIGGAAGGIA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 201 SGSMLGT-----FLVLIAGGLICQ--ALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNhpfistgeRRYITCSLAQedcs 273
Cdd:cd17341 130 GAGNMGVavsqlLAPLIAGAIVFDggFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLKV---- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 274 lgwslpIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSR 353
Cdd:cd17341 198 ------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGR 271
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568981866 354 KILRlvtirklftAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSG 407
Cdd:cd17341 272 RRLW---------WLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAG 316
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
106-444 |
1.42e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQG------MAQVMVLTGQ 179
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGigaaglGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 180 YSlwakwaPPQERSQLITIAASGSMLGTFLVLIAGGLICqALGWPYIFYIFGGIGCACCLLWFPLVYDDPqnhpfiSTGE 259
Cdd:cd17474 115 LF------EGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPK------EKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 260 RRYITCSLAQedcslgwslpiKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCV- 338
Cdd:cd17474 182 SSSATKLRDL-----------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALg 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 339 CIILGGLLADFLLSRKILrlvtirklftAVGVLASSGILLPLPWVRSsrsttMAFLVLSSVFASLCD-------SGALIN 411
Cdd:cd17474 251 SLFVGRLLKKRFGARRIL----------VIGLLLYALSLLLLGFVPS-----LALLLIAIVLFGLGLglnlpllTTLVTE 315
|
330 340 350
....*....|....*....|....*....|...
gi 568981866 412 FLDIAPRyaGFLKGLLQVFSYLAGGIAPTVAGF 444
Cdd:cd17474 316 LAPEEER--GTASSLYNFVRFLGQAVGPLLFGL 346
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
118-245 |
6.14e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 6.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 118 IAPIPTGYVAGVFGAKYVVGLGLLISSVLTlfIPLAADAGVALLIVLRVIQGMAQVMVL-TGQYSLwAKWAPPQERSQLI 196
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQ--IGCALAPNIAMLIILRFLQGFFGSSPLaIGAGTI-ADLFTPEERGKAM 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 568981866 197 TIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCAC---CLLWFPLV 245
Cdd:cd17323 126 GVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFClilIFLFLPIV 177
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
106-450 |
9.20e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 9.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAK 185
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 186 WAPPQERSQLITI--------AASGSMLGTFLVLIAGGLICQALGWPYIFYIFggigcaCCLLWFPLVYDDPQNHPFIST 257
Cdd:cd17329 116 VTTPENRTRAFSLlywainlgVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAAL------VLLFLLPETRPKRRAAEKTEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 258 GErryitcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPfmfGC 337
Cdd:cd17329 190 LR-------------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN---AL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRKILRLVTIRKLFTAVGVLASSGILLPLPWVrssrsTTMAFLVLSSVFASLCdSGALINflDIAP 417
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLI-----LAMIVLTLGEMLVFPA-VQTLVA--ALAP 319
|
330 340 350
....*....|....*....|....*....|....
gi 568981866 418 -RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQLL 450
Cdd:cd17329 320 pDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
105-445 |
1.03e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 105 QGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGVALLIVlrVIQGMA------QVMVLTG 178
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGIGsaafhpEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 179 QYSlwakwapPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPfistg 258
Cdd:cd17478 111 QAA-------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 259 erryitcslaQEDCSLGWSLPIKAMVKSL-PLWAIVvsyFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALpFMFGC 337
Cdd:cd17478 179 ----------KAAAKSSARSTLKGVWRALlLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 338 VCIILGGLLADFLLSRKILRLVTIRKLFTAVGVLASSGILlplpwvrssrstTMAFLVLSSVFASLCDSGALINFLDIAP 417
Cdd:cd17478 245 IGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW------------SYILLVLAGFLLFASFPVTVVLAQELLP 312
|
330 340
....*....|....*....|....*...
gi 568981866 418 RYAGFLKGLLQVFSYLAGGIAPTVAGFF 445
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
121-252 |
1.50e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.91 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 121 IP-TGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIA 199
Cdd:TIGR00711 54 IPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN--LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 568981866 200 ASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLL-WFPLVYDDPQNH 252
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAAS 185
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
189-403 |
2.21e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 189 PQERSQLITIAASGSMLGTFLVLIAGGLI-------CQALGWPYIFYIFGGIGCaCCLLWFplvyddpqnhpFISTGERR 261
Cdd:cd17332 131 PEERTSLTSWRMFFATIGGLLVTVLPPPLvayfgggNASRGYFLTALIIGIIGI-ILLLIC-----------FFGTRERV 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 262 YITcslAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQAnlRDSGILSALPFMFGCVCII 341
Cdd:cd17332 199 VPP---EEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGG--RAELVLLLLLILSGALLAL 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568981866 342 LGGLLADFLLSRKILrlvtirkLFTAVGVLASSGILLPLPWVRSSrSTTMAFLVLSSVFASL 403
Cdd:cd17332 274 LPWPPLKKRFGKKKA-------FFIGLLLAILGLLLLFFLPPGNL-VLILVLAVLAGIGYGG 327
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
98-442 |
2.75e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.00 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 98 YDWTPEIQGILLS--SLSYGsfIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIP--LAADAGVALLIVLRVIQGMAQV 173
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 174 MVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALG---WPYIFYIFGGIGCACCLLWFPLVYDDPQ 250
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 251 NH--PFIST--GERRYITCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSG 326
Cdd:cd17345 191 SEglPPIEEykGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAM 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 327 ILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAVGVLASSgiLLPLPWVRSSRSTTMAFLVLSSVFaslcds 406
Cdd:cd17345 271 WAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYW--LAPNVLVDLIALIALGFLIYGPVM------ 342
|
330 340 350
....*....|....*....|....*....|....*....
gi 568981866 407 gaLINF--LDIAPRYA-GFLKGLLQVFSYLAGGIAPTVA 442
Cdd:cd17345 343 --LIGLqaLELVPKKAaGTAAGLTGLFGYLGGSVLATAL 379
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
101-452 |
3.49e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.59 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAgvALLIVLRVIQGMAQVMVLTGQY 180
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLI----CQALGWPyIFYIFGGIGCACCLLWfplvyddpqnhpfis 256
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWR-ILFLIGALPALLALLL--------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 257 tgeRRYItcslaqedcslgwslpikamvkslplWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFG 336
Cdd:cd17316 176 ---RRRT--------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 337 CVCIILGGLLADFLLsrkilrlvtiRKLFTAVGVLASSGILLPLPWVRS-SRSTTMAFLVLSSVFASLCDSGALINFLDI 415
Cdd:cd17316 227 LVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSgSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 568981866 416 AP---RYAGFlkGLLQVFSYLAGGIAPTVAGFFISQLLLM 452
Cdd:cd17316 297 FPtevRATGV--GLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
101-242 |
5.60e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 101 TPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAGValLIVLRVIQGMAQVMVLTGQY 180
Cdd:TIGR00710 38 PASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET--LLVLRFVQAFGASAGSVISQ 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568981866 181 SLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWF 242
Cdd:TIGR00710 116 ALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIF 177
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
101-396 |
1.05e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.21 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 101 TPEIQGILLSSLSYGS--FIAP---IPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLA---ADAGVA---LLIVLRVIQG 169
Cdd:cd17368 33 GSEFASLLLTFATFGVgfFMRPigaIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAptyATIGIAaplLVLLARLLQG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 170 MAQVMVLTGQYSLWAKWAPPQER---------SQLITIAAsGSMLGTFLVLIAGGLICQALGWPYIFYIfgGIGCACCLL 240
Cdd:cd17368 113 FAAGGEVGGVTAYLVEAAPPGRRgfytswqsaSQQVAIVA-GALVGYLLSLTLTAEALAEWGWRIPFFI--GLLIIPLGL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 241 WFPLVYDDPQNHP-FISTGERRYITCSLAQEDCSLGWSLPIKAMvkslplwAIVVSYFCEYwllstvmaYTPTYISSVLQ 319
Cdd:cd17368 190 WLRRSLEETEAFLeRKARPTRRELFALLANNRRIILLGMLLVAG-------STVTFYFTTV--------YTPTYAKTVLG 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568981866 320 ANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILRLVTIRKLFTAVGVLAssgillplpWVRSSRSTTMAFLVL 396
Cdd:cd17368 255 LSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFA---------WLTAAPSFGRLLLVL 322
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
106-419 |
1.10e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.19 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQG------MAQVMVLTGQ 179
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGlglgglMPNLNALVSE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 180 YslwakwAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIfGGIGCAcCLLWF-------PLVYDDPQNH 252
Cdd:TIGR00895 133 Y------APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIAPL-LLLLLlmrflpeSIDFLVSKRP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 253 PFISTGERRYITCSLAQEDCSL--------GWSLPIKA-----MVKSLPLwaIVVSYFCEYWLLSTVMAYTPtYISSVLQ 319
Cdd:TIGR00895 205 ETVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKAlfqgkTARITVL--LWLLYFMLLVGVYFLTNWLP-KLMVELG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 320 ANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILrlvtirklftavGVLASSGILLPLPWVRSSRSTTMAFLVlssV 399
Cdd:TIGR00895 282 FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA------------LLLLLGAVFAVLVGSTLFSPTLLLLLG---A 346
|
330 340
....*....|....*....|
gi 568981866 400 FASLCDSGALINFLDIAPRY 419
Cdd:TIGR00895 347 IAGFFVNGGQSGLYALMALF 366
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
106-442 |
1.39e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYG-SFIAPIPTGYVAGVFGAKY------VVGLGLL-ISSVLTLFIPLAADAGVA---LLIVLRVIQGMAqvm 174
Cdd:cd17369 42 GTLAAFATFGvGFLARPLGGVVFGHFGDRIgrkktlVLTLLLMgIATFLIGLLPTYAQIGILapiLLVLLRLLQGLA--- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 175 vLTGQYS----LWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQAL--------GWPYIFyifggigcaccLLWF 242
Cdd:cd17369 119 -LGGEWGgavlMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPF-----------LLSA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 243 PLVyddpqnhpFISTGERRYITCS------LAQEDCSlgwSLPIKAMVKSLP--LWAIVVSYFCEYWLLSTVMAYTPTYI 314
Cdd:cd17369 187 VLV--------AVGLYIRLRLEETpvfrraKEAGQVV---RAPLVEVLRRHWraLLLAIGLRLAENVLFYLFTTFALSYA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 315 SSVLQANLRDSGILSALPFMFGCVCIILGGLLADfllsrKILRlvtiRKLFTaVGVLASSGILLPLPWVRSSRSTTMAFL 394
Cdd:cd17369 256 TQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSD-----RVGR----RPVYL-AGALLAALFAFPFFWLLDTGSTWLIVL 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 568981866 395 VLSSVFASLCDS-----GALINFL-DIAPRYAGFLKGlLQVFSYLAGGIAPTVA 442
Cdd:cd17369 326 AAVVVLGVLHGMmygpqAAFLAELfPTRVRYTGASLG-YQLGAILGGGFAPLIA 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
97-206 |
1.42e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAadAGVALLIVLRVIQGMAQVMVL 176
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--GSLWLLLLALFLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|
gi 568981866 177 TGQYSLWAKWAPPQERSQLITIAASGSMLG 206
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
292-449 |
1.78e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 292 IVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRKILrlvtirklftaVGVL 371
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-----------LIGL 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981866 372 ASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-GFLKGLLQVFSYLAGGIAPTVAGFFISQL 449
Cdd:pfam07690 70 LLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
97-244 |
1.85e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 97 VYDWTPEIQGILLSSLSYGSFIAPIPTGYVAGV-FGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMV 175
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLN 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568981866 176 LTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPL 244
Cdd:cd17474 306 LPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
115-407 |
1.97e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.36 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 115 GSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAADAgVALLIVLRVIQGMAQVMVLTGQYSLwAKWAPPQERSQ 194
Cdd:TIGR00886 49 AGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQS-YSVLLLIRLFIGIAGGSFASCMPWI-SFFFPKKIQGT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 195 LITIAASgsmLGTFlvliaGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIsTGERRYITCSlaqeDCSL 274
Cdd:TIGR00886 127 ALGLAAG---WGNM-----GGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLL-PALLIFFVGA----DTPP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 275 GWSLPIKAMVKS-------LPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSAL-PFMfGCVCIILGGLL 346
Cdd:TIGR00886 194 GKPATGKLSFKEalkvfgnRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLgGFL-GSLARPAGGAI 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981866 347 ADFLLSRKILrlvtirkLFTAVGVLASSGILLplpWVRSSRSTTMAFLVLSSVFASLCDSG 407
Cdd:TIGR00886 273 SDRLGGARKL-------LMNFLGVAMGAFLVV---LGLVSDGSLAAFIVLFVALFFFAGAG 323
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
124-245 |
2.04e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.26 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 124 GYVAGVFGAKYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGS 203
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGY 132
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 568981866 204 MLGTFLVLIAGGLICQALGWPYIFYIFGGIGcaccLLWFPLV 245
Cdd:cd17365 133 PLGAALGGFLAAALIPAFGWRSVFLLGGVPP----LILLPLL 170
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
161-237 |
2.18e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 161 LIVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI---FGGIGCAC 237
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInlpIGGLALAL 165
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
106-383 |
2.30e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 106 GILLSSLSYGSFIAPIPTGYVAGVFGA-KYVVGLGLLISSVLTLFIPLAADagVALLIVLRVIQGMAQVM--VLTgqySL 182
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPS--PWGLLIARFLSGIAAATwvSFT---VL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 183 WAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERry 262
Cdd:cd17490 109 YASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKE-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 263 itcslaqedcslgwslpIKAMVKSLPLWAI-VVSYFCEYWLLSTVMAYTPTYISSvLQANLRDSGILSALPFMFGcvciI 341
Cdd:cd17490 187 -----------------LLSVLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPN----A 244
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 568981866 342 LGGLLADFLLSRKIlrlvtIRKLFTAVGVLASSGILLPLPWV 383
Cdd:cd17490 245 LASLLSGTLFYKKL-----GERNTIIIGFLLLGAYCFLIPFA 281
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
87-241 |
3.23e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 87 NETLQESKAPVYDWTPeIQGILLSSLSYGSFIAPIPTGYVAGVFGAKY---VVGLGLLISSVLTLFIPLAAdaGVALLIV 163
Cdd:pfam00083 31 NFGLSKSVSSLAALSV-LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKsllIANVLFVIGAVLQGAAKGKW--SVYQLIV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 164 LRVIQGMAqVMVLTGQYSLW-AKWAPPQERSQLITIAASGSMLGTFLVLIAG---GLICQALGWPYIFY---IFGGIGCA 236
Cdd:pfam00083 108 GRVLVGIG-VGGASVLAPMYiSEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGlqlVPALLLII 186
|
....*
gi 568981866 237 CCLLW 241
Cdd:pfam00083 187 GLLFL 191
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
104-229 |
9.96e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981866 104 IQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLtlFIPLAADAGVALLIVLRVIQGMAQVMVLTGQYSLW 183
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALL--YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLL 318
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 568981866 184 AKWAPPQERSQLITIAASGSMLGTFLVLIAGGLICQALGWPYIFYI 229
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| |
