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Conserved domains on  [gi|568980774|ref|XP_006516475|]
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striatin-3 isoform X4 [Mus musculus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 427-748 2.22e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 2.22e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 427 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 506
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 507 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 586
Cdd:cd00200   73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 587 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 665
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 666 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 745
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 568980774 746 KVF 748
Cdd:cd00200  286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 5.06e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 5.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774   65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568980774  145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 427-748 2.22e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 2.22e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 427 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 506
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 507 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 586
Cdd:cd00200   73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 587 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 665
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 666 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 745
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 568980774 746 KVF 748
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
387-747 1.80e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 1.80e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 387 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 461
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 462 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 541
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 542 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 619
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 620 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 699
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 568980774 700 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 747
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 5.06e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 5.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774   65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568980774  145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 5.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568980774   664 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
665-703 1.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568980774  665 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 703
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 427-748 2.22e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 2.22e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 427 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 506
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 507 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 586
Cdd:cd00200   73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 587 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 665
Cdd:cd00200  139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 666 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 745
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                 ...
gi 568980774 746 KVF 748
Cdd:cd00200  286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
387-747 1.80e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 1.80e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 387 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 461
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 462 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 541
Cdd:COG2319  150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 542 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 619
Cdd:COG2319  208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 620 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 699
Cdd:COG2319  282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 568980774 700 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 747
Cdd:COG2319  355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 5.06e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 155.74  E-value: 5.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774   65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568980774  145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
420-706 2.30e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 2.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 420 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQ 499
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 500 CFSGGIDATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQEKlPCVCTYNG 579
Cdd:COG2319  219 LASGSADGTVRLWDL-----------ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTG 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 580 DkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKF 659
Cdd:COG2319  287 H--SGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-------VRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568980774 660 FDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 706
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
427-748 1.95e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 1.95e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 427 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 506
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------ALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 507 ATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHG 584
Cdd:COG2319  100 GTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSpdG--KTLASGSADGTVRLWDLATG-KLLRTLTGH--SG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 585 IPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSqvdsglqSSNHINRVVSHP---TLpvtITAHEDRHIKFFD 661
Cdd:COG2319  164 AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFSPdgkLL---ASGSADGTVRLWD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 662 NKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGA 741
Cdd:COG2319  233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSD 308


                 ....*..
gi 568980774 742 DALAKVF 748
Cdd:COG2319  309 DGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 530-748 8.96e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 8.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 530 LAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNpQEKLPCVCTYngdKEHGIP-TSVDFIGCDPAhMVTSFNTGSA 608
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTL---KGHTGPvRDVAASADGTY-LASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980774 609 VIYDLETSQSLVMLSSqvdsglqssnHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDP 685
Cdd:cd00200   76 RLWDLETGECVRTLTG----------HTSYVSSvafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568980774 686 NGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 748
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 5.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568980774   664 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
665-703 1.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568980774  665 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 703
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 421-460 1.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568980774   421 TWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 460
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
422-460 7.55e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 7.55e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568980774  422 WNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 460
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-566 1.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568980774   533 TLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 566
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
532-566 8.50e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 8.50e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568980774  532 GTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 566
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
419-462 1.03e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568980774 419 RKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 462
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-513 1.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568980774   476 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 513
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-513 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568980774  476 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 513
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 706-748 7.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 7.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568980774   706 SKTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 748
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 665-730 5.10e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 5.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980774  665 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL--------DSKTCVQEItaHRKklDESIYDVAFH 730
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEF--PRK--DHVIAETPFH 183
WD40 pfam00400
WD domain, G-beta repeat;
707-748 5.51e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568980774  707 KTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 748
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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