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Conserved domains on  [gi|568980701|ref|XP_006516441|]
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leucine-rich repeat-containing protein 9 isoform X4 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 6.16e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 121.82  E-value: 6.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340    81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568980701  183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340   160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1107-1352 1.83e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 106.02  E-value: 1.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1107 FRNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESImprlkpqthlssrqllyqkvpssgygqqgtsklnrdsvgsE 1186
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI----------------------------------------E 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1187 NLPPiMQSLEVLHLGYNgicNLVQLQ-LNRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRIR-----AFN-DTAF 1259
Cdd:cd21340    41 NLEF-LTNLTHLYLQNN---QIEKIEnLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPpgeklTFDpRSLA 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1260 SKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEklDVI---PSLRELTVYGNPICRKMVHRHVLIFRL 1336
Cdd:cd21340   117 ALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLsswPSLRELDLTGNPVCKKPKYRDKIILAS 194

                         250
                  ....*....|....*.
gi 568980701 1337 PNLQMLDGIPINSDDR 1352
Cdd:cd21340   195 KSLEVLDGKEITDTER 210
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 877-1057 1.08e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 86.38  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 YSKITALNLDGQHLFEITNL----------------EKLENLKWASF------SNNNLSKMEGLESCVNLEELTLDGNCI 934
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLslcknlkvlylydnkiTKIENLEFLTNlthlylQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  935 SKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSL------ENNRITSLSALQKTFTLIELYISNNYIAVNQEI 1008
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSlrvlniSGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568980701 1009 YN-LKGLCNLVILDMYGNIIIwNQENYRFFVIFHLPELKALDGVSIETSE 1057
Cdd:cd21340   161 LDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
642-1048 1.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  642 LVFSQDLKFDDEVLKMEPRIKPRPKLISLDEKTIISLAKTNIYSHIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEftc 721
Cdd:COG4886    31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  722 ldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKTGEEINVLckhtTSLLTLDIQHNpwqkpatlRLS- 799
Cdd:COG4886   108 --ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNLKSLDLSNN--------QLTd 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  800 ---VIGRLKTLTHLDglviseeetraalkfISGTKITQLtllqhssskeerPRMLSTWPSAKILtqisklgphfHLTGNw 876
Cdd:COG4886   174 lpeELGNLTNLKELD---------------LSNNQITDL------------PEPLGNLTNLEEL----------DLSGN- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 ysKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLL 956
Cdd:COG4886   216 --QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  957 TGLEKHTFDNLLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMYGNIIIWNQENYRF 1036
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         410
                  ....*....|..
gi 568980701 1037 FVIFHLPELKAL 1048
Cdd:COG4886   365 LLLTLGLLGLLE 376
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 6.16e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 121.82  E-value: 6.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340    81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568980701  183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340   160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1107-1352 1.83e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 106.02  E-value: 1.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1107 FRNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESImprlkpqthlssrqllyqkvpssgygqqgtsklnrdsvgsE 1186
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI----------------------------------------E 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1187 NLPPiMQSLEVLHLGYNgicNLVQLQ-LNRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRIR-----AFN-DTAF 1259
Cdd:cd21340    41 NLEF-LTNLTHLYLQNN---QIEKIEnLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPpgeklTFDpRSLA 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1260 SKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEklDVI---PSLRELTVYGNPICRKMVHRHVLIFRL 1336
Cdd:cd21340   117 ALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLsswPSLRELDLTGNPVCKKPKYRDKIILAS 194

                         250
                  ....*....|....*.
gi 568980701 1337 PNLQMLDGIPINSDDR 1352
Cdd:cd21340   195 KSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 877-1057 1.08e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.38  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 YSKITALNLDGQHLFEITNL----------------EKLENLKWASF------SNNNLSKMEGLESCVNLEELTLDGNCI 934
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLslcknlkvlylydnkiTKIENLEFLTNlthlylQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  935 SKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSL------ENNRITSLSALQKTFTLIELYISNNYIAVNQEI 1008
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSlrvlniSGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568980701 1009 YN-LKGLCNLVILDMYGNIIIwNQENYRFFVIFHLPELKALDGVSIETSE 1057
Cdd:cd21340   161 LDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
642-1048 1.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  642 LVFSQDLKFDDEVLKMEPRIKPRPKLISLDEKTIISLAKTNIYSHIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEftc 721
Cdd:COG4886    31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  722 ldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKTGEEINVLckhtTSLLTLDIQHNpwqkpatlRLS- 799
Cdd:COG4886   108 --ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNLKSLDLSNN--------QLTd 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  800 ---VIGRLKTLTHLDglviseeetraalkfISGTKITQLtllqhssskeerPRMLSTWPSAKILtqisklgphfHLTGNw 876
Cdd:COG4886   174 lpeELGNLTNLKELD---------------LSNNQITDL------------PEPLGNLTNLEEL----------DLSGN- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 ysKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLL 956
Cdd:COG4886   216 --QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  957 TGLEKHTFDNLLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMYGNIIIWNQENYRF 1036
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         410
                  ....*....|..
gi 568980701 1037 FVIFHLPELKAL 1048
Cdd:COG4886   365 LLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1103-1322 5.41e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1103 PVDHFRNVSNVNLQNNNLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPqthlssrqllyqkvpssgygqqgtsklnrd 1181
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGN------------------------------ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1182 svgsenlppiMQSLEVLHLGYNGICNLvQLQLNRLRNLKFLFLQGNEISQV-EGLDNLIVLQELVVDHNRIRAFNDtAFS 1260
Cdd:COG4886   158 ----------LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPE-PLA 225

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980701 1261 KPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEKLdviPSLRELTVYGNPI 1322
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 685-825 1.03e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  685 SHIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 734
Cdd:cd21340    46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  735 DASHNHVITLEGFRGLMKLKHLDLSWNQLKKtGEEINVLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLV 814
Cdd:cd21340   126 NISGNNIDSLEPLAPLRNLEQLDASNNQISD-LEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         170
                  ....*....|.
gi 568980701  815 ISEEEtRAALK 825
Cdd:cd21340   205 ITDTE-RQFLK 214
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-195 2.86e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   50 LSLFHNLSSLTIVAQDIREISG-LETCLQLKELWIAECCIEKI-EGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWL 127
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDL 257

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  128 NHNMIKNIEGLQTLKNLKDLNLAGNLVSSIG-RCLDPNEQLEKLNLSGNQITSFKDLTNLTKLTRLKDL 195
Cdd:COG4886   258 SNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR_9 pfam14580
Leucine-rich repeat;
108-242 2.91e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 2.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   108 NKISKIENL-EKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLD---PNeqLEKLNLSGNQITSFKDL 183
Cdd:pfam14580   29 YKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGealPN--LTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701   184 TNLTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKELAD 242
Cdd:pfam14580  107 DPLASLKKLTFLSLLR-----NPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR_8 pfam13855
Leucine rich repeat;
1241-1297 1.36e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.36e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  1241 LQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSK--LQSLVKLEKLFLGYNKI 1297
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
707-763 2.26e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 2.26e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980701   707 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 763
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
932-1076 3.81e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.83  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   932 NCISKIEGITRLTKLSRLSMNNNLLT----GLEkhtfdnllhlhslslennritslsalQKTFTLIELYISNNYIAVNQE 1007
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICrigeGLG--------------------------EALPNLTELILTNNNLQELGD 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  1008 IYNLKGLCNLVILDMYGNIIIwNQENYRFFVIFHLPELKALDGVSIETSETETAKDLFGGRLTSDMIAE 1076
Cdd:pfam14580  106 LDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-236 6.16e-31

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 121.82  E-value: 6.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   53 FHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNHNMI 132
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  133 KNIEGLQTLKNLKDL------------------------------NLAGNLVSSIgRCLDPNEQLEKLNLSGNQITSFKD 182
Cdd:cd21340    81 SVVEGLENLTNLEELhienqrlppgekltfdprslaalsnslrvlNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568980701  183 LTN-LTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQ 236
Cdd:cd21340   160 LLDlLSSWPSLRELDLTG-----NPVCKKPKYRDKIILASKSLEVLDGKEITDTE 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1107-1352 1.83e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 106.02  E-value: 1.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1107 FRNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESImprlkpqthlssrqllyqkvpssgygqqgtsklnrdsvgsE 1186
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI----------------------------------------E 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1187 NLPPiMQSLEVLHLGYNgicNLVQLQ-LNRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRIR-----AFN-DTAF 1259
Cdd:cd21340    41 NLEF-LTNLTHLYLQNN---QIEKIEnLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPpgeklTFDpRSLA 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1260 SKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEklDVI---PSLRELTVYGNPICRKMVHRHVLIFRL 1336
Cdd:cd21340   117 ALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLsswPSLRELDLTGNPVCKKPKYRDKIILAS 194

                         250
                  ....*....|....*.
gi 568980701 1337 PNLQMLDGIPINSDDR 1352
Cdd:cd21340   195 KSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-179 6.03e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.15  E-value: 6.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   47 IVGLSLFHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLE--- 123
Cdd:cd21340    17 IDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelh 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  124 ---------------------------VLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLDP---NEQLEKLNLS 173
Cdd:cd21340    97 ienqrlppgekltfdprslaalsnslrVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLlssWPSLRELDLT 176


                  ....*.
gi 568980701  174 GNQITS 179
Cdd:cd21340   177 GNPVCK 182
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 877-1057 1.08e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.38  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 YSKITALNLDGQHLFEITNL----------------EKLENLKWASF------SNNNLSKMEGLESCVNLEELTLDGNCI 934
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLslcknlkvlylydnkiTKIENLEFLTNlthlylQNNQIEKIENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  935 SKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSL------ENNRITSLSALQKTFTLIELYISNNYIAVNQEI 1008
Cdd:cd21340    81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALSNSlrvlniSGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568980701 1009 YN-LKGLCNLVILDMYGNIIIwNQENYRFFVIFHLPELKALDGVSIETSE 1057
Cdd:cd21340   161 LDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
642-1048 1.19e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  642 LVFSQDLKFDDEVLKMEPRIKPRPKLISLDEKTIISLAKTNIYSHIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEftc 721
Cdd:COG4886    31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  722 ldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKTGEEINVLckhtTSLLTLDIQHNpwqkpatlRLS- 799
Cdd:COG4886   108 --ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNLKSLDLSNN--------QLTd 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  800 ---VIGRLKTLTHLDglviseeetraalkfISGTKITQLtllqhssskeerPRMLSTWPSAKILtqisklgphfHLTGNw 876
Cdd:COG4886   174 lpeELGNLTNLKELD---------------LSNNQITDL------------PEPLGNLTNLEEL----------DLSGN- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  877 ysKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLL 956
Cdd:COG4886   216 --QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  957 TGLEKHTFDNLLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMYGNIIIWNQENYRF 1036
Cdd:COG4886   285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                         410
                  ....*....|..
gi 568980701 1037 FVIFHLPELKAL 1048
Cdd:COG4886   365 LLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1103-1322 5.41e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1103 PVDHFRNVSNVNLQNNNLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPqthlssrqllyqkvpssgygqqgtsklnrd 1181
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGN------------------------------ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1182 svgsenlppiMQSLEVLHLGYNGICNLvQLQLNRLRNLKFLFLQGNEISQV-EGLDNLIVLQELVVDHNRIRAFNDtAFS 1260
Cdd:COG4886   158 ----------LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPE-PLA 225

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980701 1261 KPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEKLdviPSLRELTVYGNPI 1322
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 685-825 1.03e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  685 SHIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 734
Cdd:cd21340    46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  735 DASHNHVITLEGFRGLMKLKHLDLSWNQLKKtGEEINVLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLV 814
Cdd:cd21340   126 NISGNNIDSLEPLAPLRNLEQLDASNNQISD-LEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         170
                  ....*....|.
gi 568980701  815 ISEEEtRAALK 825
Cdd:cd21340   205 ITDTE-RQFLK 214
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-195 2.86e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   50 LSLFHNLSSLTIVAQDIREISG-LETCLQLKELWIAECCIEKI-EGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWL 127
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDL 257

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  128 NHNMIKNIEGLQTLKNLKDLNLAGNLVSSIG-RCLDPNEQLEKLNLSGNQITSFKDLTNLTKLTRLKDL 195
Cdd:COG4886   258 SNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR_9 pfam14580
Leucine-rich repeat;
108-242 2.91e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 2.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   108 NKISKIENL-EKLIKLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLD---PNeqLEKLNLSGNQITSFKDL 183
Cdd:pfam14580   29 YKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGealPN--LTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701   184 TNLTKLTRLKDLCLNDpqyksNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKELAD 242
Cdd:pfam14580  107 DPLASLKKLTFLSLLR-----NPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
685-1010 3.48e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  685 SHIVNLNLHGNSLSKL-RDLAKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWN 761
Cdd:COG4886   113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  762 QLKKTGEEINVLckhtTSLLTLDIQHNpwqkpatlRLS----VIGRLKTLTHLDglviseeetraalkfISGTKITQLTL 837
Cdd:COG4886   193 QITDLPEPLGNL----TNLEELDLSGN--------QLTdlpePLANLTNLETLD---------------LSNNQLTDLPE 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  838 LQHSSSKEE---RPRMLSTWPSAKILTQISKLgphfHLTGNwysKITALNLDGQHLFEITNLEKLENLKWASFSNNNLSK 914
Cdd:COG4886   246 LGNLTNLEEldlSNNQLTDLPPLANLTNLKTL----DLSNN---QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  915 MEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSLENNRITSLSALQKTFTLIE 994
Cdd:COG4886   319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398

                         330
                  ....*....|....*.
gi 568980701  995 LYISNNYIAVNQEIYN 1010
Cdd:COG4886   399 GVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-282 7.98e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 7.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   50 LSLFHNLSSLTIVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLIKLEVLWLNH 129
Cdd:COG4886    26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  130 NmikniEGLQTLKNLKDLNLAGNLVSSIGRCLDPNEQLEKLNLSGNQITSFKDltNLTKLTRLKDLCLNDpqyksNPVCQ 209
Cdd:COG4886   106 N-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLDLSN-----NQLTD 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  210 LcnysTHVLYHLPSLQRLdtfDVSAKQIKELADS----TAMKKIMYYNMRIKTVQRHLNE--ELEKLNDRKCKLQKLPE 282
Cdd:COG4886   174 L----PEELGNLTNLKEL---DLSNNQITDLPEPlgnlTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE 245
LRR_8 pfam13855
Leucine rich repeat;
1241-1297 1.36e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.36e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  1241 LQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSK--LQSLVKLEKLFLGYNKI 1297
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
977-1304 2.32e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  977 NNRITSLSALQKTFTLIELYISNNYIAVNQEIYNLKGLCNLVILDMYGNIIIWNQENYRFFVIFHLPELKALDGVSIETS 1056
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1057 ETETAKDLFGgrLTSDMIAERQGHSNFIQMQELNWTSSAIRTVDlIPVDHFRNVSNVNLQNNNLTSF-SGLIYLPNVKVL 1135
Cdd:COG4886    88 GLTDLGDLTN--LTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1136 CLNYNHIESIMPRLKPQTHLSSRQLLYQKVPSSGYGQQGTSKLNRDSVGS---ENLPPI---MQSLEVLHLGYNGICNLV 1209
Cdd:COG4886   165 DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGnqlTDLPEPlanLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1210 QLQlnRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSKLQSLVKLEK 1289
Cdd:COG4886   245 ELG--NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         330
                  ....*....|....*
gi 568980701 1290 LFLGYNKIQDITELE 1304
Cdd:COG4886   323 LLLLLLLLKGLLVTL 337
LRR_9 pfam14580
Leucine-rich repeat;
1224-1365 4.20e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.69  E-value: 4.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  1224 LQGNEISQVEGLDNLIVLQELVVDHNRIrafndtafskpssllmLHLEENRLRELSKLQSLVkleklfLGYNKIQDITEL 1303
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEGLGEALPNLTELI------LTNNNLQELGDL 106

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980701  1304 EKLDVIPSLRELTVYGNPICRKMVHRHVLIFRLPNLQMLDGIPINSDDRAKAEFHFSELQAK 1365
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
872-1304 9.14e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 9.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  872 LTGNWYSKITALNLDGQHLFEITNLEKLENLKWASFSNNNlskmeGLESCVNLEELTLDGNCISKI-EGITRLTKLSRLS 950
Cdd:COG4886    68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  951 MNNNLLTGLEKhtfdnllhlhslslennritSLSALQKtftLIELYISNNYIA-VNQEIYNLKglcNLVILDMYGNIIiw 1029
Cdd:COG4886   143 LSNNQLTDLPE--------------------PLGNLTN---LKSLDLSNNQLTdLPEELGNLT---NLKELDLSNNQI-- 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1030 nqenyrffvifhlpelkaldgvsietseTETAKDLfggrltsdmiaerqghSNFIQMQELNWTSSAIRTVDLiPVDHFRN 1109
Cdd:COG4886   195 ----------------------------TDLPEPL----------------GNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1110 VSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLSSRQLLYQKVpssgygqqgtSKLNRDSVGSENLP 1189
Cdd:COG4886   230 LETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQL----------TDLKLKELELLLGL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701 1190 PIMQSLEVLHLGYNGICNLVQLQLNRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLH 1269
Cdd:COG4886   299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 568980701 1270 LEENRLRELSKLQSLVKLEKLFLGYNKIQDITELE 1304
Cdd:COG4886   379 LLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR_8 pfam13855
Leucine rich repeat;
707-763 2.26e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 2.26e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980701   707 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 763
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-138 1.50e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.39  E-value: 1.50e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568980701    99 NLEKLYLYYNKISKIENLEKLIKLEVLWLNHN-MIKNIEGL 138
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 660-741 1.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701  660 RIKPRPKLIsLDEKTIISLAKTniyshIVNLNLHGNSLSKLRDLAKLTGLRKLNISFNEFTCLDDV----YHLYNLEYLD 735
Cdd:cd21340   101 RLPPGEKLT-FDPRSLAALSNS-----LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLRELD 174


                  ....*.
gi 568980701  736 ASHNHV 741
Cdd:cd21340   175 LTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-201 5.81e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   69 ISGLETCLQLKELWI------AECCIEKIEGLQGCRNLEKLYLYYNKISkienlekliklevlwlNHNMIKNIEGLQTLK 142
Cdd:COG5238   285 AKALQGNTTLTSLDLsvnrigDEGAIALAEGLQGNKTLHTLNLAYNGIG----------------AQGAIALAKALQENT 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980701  143 NLKDLNLAGNLVS-----SIGRCLDPNEQLEKLNLSGNQITS--FKDLTNLTKLTRLKDLCLNDPQ 201
Cdd:COG5238   349 TLHSLDLSDNQIGdegaiALAKYLEGNTTLRELNLGKNNIGKqgAEALIDALQTNRLHTLILDGNL 414
LRR_8 pfam13855
Leucine rich repeat;
121-177 6.00e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 6.00e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   121 KLEVLWLNHNMIKNIEG--LQTLKNLKDLNLAGNLVSSI-GRCLDPNEQLEKLNLSGNQI 177
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-152 1.55e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568980701   121 KLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGN 152
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
685-741 3.04e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 3.04e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980701   685 SHIVNLNLHGNSLSKLRD--LAKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 741
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
932-1076 3.81e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.83  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   932 NCISKIEGITRLTKLSRLSMNNNLLT----GLEkhtfdnllhlhslslennritslsalQKTFTLIELYISNNYIAVNQE 1007
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICrigeGLG--------------------------EALPNLTELILTNNNLQELGD 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980701  1008 IYNLKGLCNLVILDMYGNIIIwNQENYRFFVIFHLPELKALDGVSIETSETETAKDLFGGRLTSDMIAE 1076
Cdd:pfam14580  106 LDPLASLKKLTFLSLLRNPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-178 1.11e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980701   84 AECCIEKIEGLQGCRNLEKLYLYYNKISK------IENLEKLIKLEVLWLNHNMIKNI------EGLQTLKNLKDLNLAG 151
Cdd:cd00116   151 GASCEALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGD 230

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568980701  152 NLVSSIGRC------LDPNEQLEKLNLSGNQIT 178
Cdd:cd00116   231 NNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-118 1.72e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568980701    77 QLKELWIAECCIEKIEGLQGCRNLEKLYLYYN-KISKIENLEK 118
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
1217-1275 2.59e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 2.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980701  1217 RNLKFLFLQGNEISQVEG--LDNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRL 1275
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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