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Conserved domains on  [gi|568980367|ref|XP_006516280|]
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BAG family molecular chaperone regulator 5 isoform X1 [Mus musculus]

Protein Classification

BAG family molecular chaperone regulator( domain architecture ID 10644980)

BAG (Bcl-2 associated athanogene) family molecular chaperone regulator which may function as a co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses; similar to Homo sapiens BAG family molecular chaperone regulators

CATH:  1.20.58.120
Gene Ontology:  GO:0051087|GO:0006457
PubMed:  12406544
SCOP:  4002965

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 2.56e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 76.19  E-value: 2.56e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367     9 SISRLQEIQREVK-AIEPQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 366-442 8.60e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 71.96  E-value: 8.60e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980367   366 HKAVWEILGNL-SEILGEVLSFGGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKS 442
Cdd:smart00264   2 IKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.76e-15

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 70.42  E-value: 2.76e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   182 SVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 6.51e-11

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 58.09  E-value: 6.51e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   275 SIIKIENVLKRMR-EIKNELLQA--QSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 2.56e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 76.19  E-value: 2.56e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367     9 SISRLQEIQREVK-AIEPQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 366-442 8.60e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 71.96  E-value: 8.60e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980367   366 HKAVWEILGNL-SEILGEVLSFGGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKS 442
Cdd:smart00264   2 IKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.76e-15

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 70.42  E-value: 2.76e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   182 SVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 13-84 1.51e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 68.41  E-value: 1.51e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980367   13 LQEIQREVKAIEPQVVGFSGLSD----DKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQ 84
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPskkrDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 369-441 4.82e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 66.87  E-value: 4.82e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980367  369 VWEILGNLSEILGEVLSFGGN----RTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMK 441
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSppskKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 6.51e-11

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 58.09  E-value: 6.51e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   275 SIIKIENVLKRMR-EIKNELLQA--QSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 186-258 9.33e-08

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 49.15  E-value: 9.33e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980367  186 INSVMCEVNKARG---TLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDL 258
Cdd:pfam02179   1 IDAILKEVDKLEPqveAFEGSPPSKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 279-349 5.07e-07

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 47.22  E-value: 5.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980367  279 IENVLKRMREIKNEL--LQAQSPPEL----YLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLK 349
Cdd:pfam02179   1 IDAILKEVDKLEPQVeaFEGSPPSKKrdkeYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 9-86 2.56e-17

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 76.19  E-value: 2.56e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367     9 SISRLQEIQREVK-AIEPQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNA 86
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 366-442 8.60e-16

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 71.96  E-value: 8.60e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980367   366 HKAVWEILGNL-SEILGEVLSFGGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMKS 442
Cdd:smart00264   2 IKKINEVLDEVqKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 182-260 2.76e-15

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 70.42  E-value: 2.76e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   182 SVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEE 260
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 13-84 1.51e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 68.41  E-value: 1.51e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980367   13 LQEIQREVKAIEPQVVGFSGLSD----DKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQ 84
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSPPskkrDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 369-441 4.82e-14

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 66.87  E-value: 4.82e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980367  369 VWEILGNLSEILGEVLSFGGN----RTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVKLAQNILSYLDMK 441
Cdd:pfam02179   1 IDAILKEVDKLEPQVEAFEGSppskKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 275-350 6.51e-11

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 58.09  E-value: 6.51e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980367   275 SIIKIENVLKRMR-EIKNELLQA--QSPPELYLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLKE 350
Cdd:smart00264   1 SIKKINEVLDEVQkKIEKEVQVAdgKKDDKEYLRLSEELMKLLLKLDSVDVEGCEDIREARKRLVRLIQNLLNALDSKK 79
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 186-258 9.33e-08

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 49.15  E-value: 9.33e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980367  186 INSVMCEVNKARG---TLIALLMGVDSSETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDL 258
Cdd:pfam02179   1 IDAILKEVDKLEPqveAFEGSPPSKKRDKEYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDA 76
BAG pfam02179
BAG domain; Domain present in Hsp70 regulators.
 279-349 5.07e-07

BAG domain; Domain present in Hsp70 regulators.


Pssm-ID: 460475 [Multi-domain]  Cd Length: 77  Bit Score: 47.22  E-value: 5.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980367  279 IENVLKRMREIKNEL--LQAQSPPEL----YLRAKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQILITYLDLK 349
Cdd:pfam02179   1 IDAILKEVDKLEPQVeaFEGSPPSKKrdkeYKRLSEMLMKLLLKLDGIDTEGDPEAREARKAAVKEVQGLLEKLDAL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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