|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465143 Cd Length: 412 Bit Score: 760.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 568968347 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 super family |
cl34960 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-707 |
3.82e-83 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
The actual alignment was detected with superfamily member COG5259:
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 281.77 E-value: 3.82e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 539 SGLVPLQPKPP-------QSSASQQM---------LNFPEK-GKEKPADMQ-----------------NFG----LRTDM 580
Cdd:COG5259 167 RGLSPFLPWGPinqrvlgAKEIEYEThkeenyspsLKSPKKeSQGKVDELKdhsekhpsscsccgnksFNTryhnLRAEK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 581 YT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIE 644
Cdd:COG5259 247 YNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPIE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 645 DPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 707
Cdd:COG5259 327 DNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
683-749 |
1.10e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.70 E-value: 1.10e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 683 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 749
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
879-945 |
1.65e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.65e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 879 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 945
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
962-1201 |
4.14e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 962 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1041
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1042 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1119
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1120 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1185
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 568968347 1186 --LPDPGTPLPPDPTAPS 1201
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 super family |
cl31754 |
MAEBL; Provisional |
689-925 |
1.05e-04 |
|
MAEBL; Provisional
The actual alignment was detected with superfamily member PTZ00121:
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 689 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 763
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 764 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 830
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 831 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 910
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 568968347 911 IMDREREALEYQRQQ 925
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465143 Cd Length: 412 Bit Score: 760.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 568968347 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 |
COG5259 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-707 |
3.82e-83 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 281.77 E-value: 3.82e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 539 SGLVPLQPKPP-------QSSASQQM---------LNFPEK-GKEKPADMQ-----------------NFG----LRTDM 580
Cdd:COG5259 167 RGLSPFLPWGPinqrvlgAKEIEYEThkeenyspsLKSPKKeSQGKVDELKdhsekhpsscsccgnksFNTryhnLRAEK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 581 YT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIE 644
Cdd:COG5259 247 YNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPIE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 645 DPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 707
Cdd:COG5259 327 DNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM |
pfam04433 |
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ... |
433-512 |
7.78e-37 |
|
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.
Pssm-ID: 461307 [Multi-domain] Cd Length: 78 Bit Score: 133.07 E-value: 7.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 433 FDYNSVHAIERRALPEFFNGKnkSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINY 512
Cdd:pfam04433 1 SDPDKLHPIEKRLLPEFFNGK--SKTPEVYLEIRNFILNLWRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLINF 78
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
683-749 |
1.10e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.70 E-value: 1.10e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 683 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 749
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
879-945 |
1.65e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.65e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 879 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 945
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| CHROMO |
smart00298 |
Chromatin organization modifier domain; |
187-222 |
1.13e-05 |
|
Chromatin organization modifier domain;
Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 43.74 E-value: 1.13e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568968347 187 EEEWVRPVMKR-----DKQVLLHWGYYPDSYDTWIPASEIE 222
Cdd:smart00298 1 EYEVEKILDHRwkkkgELEYLVKWKGYSYSEDTWEPEENLL 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
962-1201 |
4.14e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 962 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1041
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1042 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1119
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1120 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1185
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 568968347 1186 --LPDPGTPLPPDPTAPS 1201
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
689-925 |
1.05e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 689 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 763
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 764 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 830
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 831 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 910
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 568968347 911 IMDREREALEYQRQQ 925
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
961-1200 |
5.40e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.37 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 961 PPTLPPGSQPIPPTGAAGPPTVHGLAVPPAAVASAPPGSGAPPGSLGPSEQIGQAGT-TAGPQQPQQAGAPQPGAVPPGV 1039
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1040 PPPGPHGPSPFPNQPTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPppppaapsviPFGSLADSISINLPPPPNLHGHHH 1119
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQVPPGPSPAAPGQ 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1120 H-----------------------LPFAPGTI----PPPNLPV-------SMANPLHPNLPATTTMPSSLPLGPGLGSaa 1165
Cdd:pfam03154 321 SqqrihtppsqsqlqsqqppreqpLPPAPLSMphikPPPTTPIpqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPALKP-- 398
|
250 260 270
....*....|....*....|....*....|....*....
gi 568968347 1166 aqspaiVAAVQGNLLPSASPLP----DPGTPLPPDPTAP 1200
Cdd:pfam03154 399 ------LSSLSTHHPPSAHPPPlqlmPQSQQLPPPPAQP 431
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
731-931 |
1.05e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 43.45 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 731 AFGLESSGIAGTASDEPERIEESGTEEARPEGQAADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGkEGDSEKESE 810
Cdd:TIGR00927 626 ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEG-EGEIEAKEA 704
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 811 KSDGDPIV---------DPEKDKEPTEGQEEVLKEVAEPEGE--------RKTKVERDIGEGNLSTAAAAALAAAAVKAK 873
Cdd:TIGR00927 705 DHKGETEAeevehegetEAEGTEDEGEIETGEEGEEVEDEGEgeaegkheVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 568968347 874 HLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 931
Cdd:TIGR00927 785 AGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQ 842
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
716-946 |
5.78e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.62 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 716 RKVEEAAKVTGKADPAFGLESSGIAgtasDEPERIEESGTEEARPEGQAADEKKEPKEpregggaveeeakEEISEVPKK 795
Cdd:pfam02029 77 KRLQEALERQKEFDPTIADEKESVA----ERKENNEEEENSSWEKEEKRDSRLGRYKE-------------EETEIREKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 796 DEEKGKEGDSEKESEKSDGDPIVDPEKDKEPTEG--QEEVLKEVAEPEGERKTKV------ERDIGEGNLSTAAAAALAA 867
Cdd:pfam02029 140 YQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENfaKEEVKDEKIKKEKKVKYESkvfldqKRGHPEVKSQNGEEEVTKL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 868 AAVKAKHLAAVEERKIKSL-VALLVETQMKKLEIKLRH---------------------FEELETIMDREREALEYQRQQ 925
Cdd:pfam02029 220 KVTTKRRQGGLSQSQEREEeAEVFLEAEQKLEELRRRRqekeseefeklrqkqqeaeleLEELKKKREERRKLLEEEEQR 299
|
250 260
....*....|....*....|.
gi 568968347 926 llaDRQAFHMEQLKYAEMRAR 946
Cdd:pfam02029 300 ---RKQEEAERKLREEEEKRR 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465143 Cd Length: 412 Bit Score: 760.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 568968347 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 |
COG5259 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-707 |
3.82e-83 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 281.77 E-value: 3.82e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 539 SGLVPLQPKPP-------QSSASQQM---------LNFPEK-GKEKPADMQ-----------------NFG----LRTDM 580
Cdd:COG5259 167 RGLSPFLPWGPinqrvlgAKEIEYEThkeenyspsLKSPKKeSQGKVDELKdhsekhpsscsccgnksFNTryhnLRAEK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 581 YT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIE 644
Cdd:COG5259 247 YNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPIE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 645 DPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 707
Cdd:COG5259 327 DNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM |
pfam04433 |
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ... |
433-512 |
7.78e-37 |
|
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.
Pssm-ID: 461307 [Multi-domain] Cd Length: 78 Bit Score: 133.07 E-value: 7.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 433 FDYNSVHAIERRALPEFFNGKnkSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINY 512
Cdd:pfam04433 1 SDPDKLHPIEKRLLPEFFNGK--SKTPEVYLEIRNFILNLWRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLINF 78
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
683-749 |
1.10e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.70 E-value: 1.10e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 683 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 749
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
879-945 |
1.65e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.65e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568968347 879 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 945
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| CHROMO |
smart00298 |
Chromatin organization modifier domain; |
187-222 |
1.13e-05 |
|
Chromatin organization modifier domain;
Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 43.74 E-value: 1.13e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 568968347 187 EEEWVRPVMKR-----DKQVLLHWGYYPDSYDTWIPASEIE 222
Cdd:smart00298 1 EYEVEKILDHRwkkkgELEYLVKWKGYSYSEDTWEPEENLL 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
962-1201 |
4.14e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 962 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1041
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1042 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1119
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1120 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1185
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 568968347 1186 --LPDPGTPLPPDPTAPS 1201
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
689-925 |
1.05e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 689 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 763
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 764 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 830
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 831 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 910
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 568968347 911 IMDREREALEYQRQQ 925
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
961-1200 |
5.40e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.37 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 961 PPTLPPGSQPIPPTGAAGPPTVHGLAVPPAAVASAPPGSGAPPGSLGPSEQIGQAGT-TAGPQQPQQAGAPQPGAVPPGV 1039
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1040 PPPGPHGPSPFPNQPTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPppppaapsviPFGSLADSISINLPPPPNLHGHHH 1119
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQVPPGPSPAAPGQ 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1120 H-----------------------LPFAPGTI----PPPNLPV-------SMANPLHPNLPATTTMPSSLPLGPGLGSaa 1165
Cdd:pfam03154 321 SqqrihtppsqsqlqsqqppreqpLPPAPLSMphikPPPTTPIpqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPALKP-- 398
|
250 260 270
....*....|....*....|....*....|....*....
gi 568968347 1166 aqspaiVAAVQGNLLPSASPLP----DPGTPLPPDPTAP 1200
Cdd:pfam03154 399 ------LSSLSTHHPPSAHPPPlqlmPQSQQLPPPPAQP 431
|
|
| Myb_DNA-binding |
pfam00249 |
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
614-641 |
5.75e-04 |
|
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.
Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 38.64 E-value: 5.75e-04
10 20
....*....|....*....|....*...
gi 568968347 614 MYKDDWNKVSEHVGSRTQDECILHFLRL 641
Cdd:pfam00249 18 KLGNRWKKIAKLLPGRTDNQCKNRWQNY 45
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
731-931 |
1.05e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 43.45 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 731 AFGLESSGIAGTASDEPERIEESGTEEARPEGQAADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGkEGDSEKESE 810
Cdd:TIGR00927 626 ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEG-EGEIEAKEA 704
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 811 KSDGDPIV---------DPEKDKEPTEGQEEVLKEVAEPEGE--------RKTKVERDIGEGNLSTAAAAALAAAAVKAK 873
Cdd:TIGR00927 705 DHKGETEAeevehegetEAEGTEDEGEIETGEEGEEVEDEGEgeaegkheVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 568968347 874 HLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 931
Cdd:TIGR00927 785 AGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQ 842
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
690-942 |
2.59e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.44 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 690 AAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAKvtgKADPAFGLESsgiAGTASDEPERIEES-GTEEARP--EGQAAD 766
Cdd:PTZ00121 1466 AEEAKKADEAKKKAEEAKKA--DEAKKKAEEAKK---KADEAKKAAE---AKKKADEAKKAEEAkKADEAKKaeEAKKAD 1537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 767 EKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPEKDKEPTEGQEEVLKEVAE---PEGE 843
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEeakKAEE 1617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 844 RKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAV----EERKIKSlvallvETQMKKLEIKLRHFEELETIMDREREAL 919
Cdd:PTZ00121 1618 AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELkkaeEENKIKA------AEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691
|
250 260
....*....|....*....|...
gi 568968347 920 EYQRQQLLADRQAfhmEQLKYAE 942
Cdd:PTZ00121 1692 EALKKEAEEAKKA---EELKKKE 1711
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
716-946 |
5.78e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.62 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 716 RKVEEAAKVTGKADPAFGLESSGIAgtasDEPERIEESGTEEARPEGQAADEKKEPKEpregggaveeeakEEISEVPKK 795
Cdd:pfam02029 77 KRLQEALERQKEFDPTIADEKESVA----ERKENNEEEENSSWEKEEKRDSRLGRYKE-------------EETEIREKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 796 DEEKGKEGDSEKESEKSDGDPIVDPEKDKEPTEG--QEEVLKEVAEPEGERKTKV------ERDIGEGNLSTAAAAALAA 867
Cdd:pfam02029 140 YQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENfaKEEVKDEKIKKEKKVKYESkvfldqKRGHPEVKSQNGEEEVTKL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 868 AAVKAKHLAAVEERKIKSL-VALLVETQMKKLEIKLRH---------------------FEELETIMDREREALEYQRQQ 925
Cdd:pfam02029 220 KVTTKRRQGGLSQSQEREEeAEVFLEAEQKLEELRRRRqekeseefeklrqkqqeaeleLEELKKKREERRKLLEEEEQR 299
|
250 260
....*....|....*....|.
gi 568968347 926 llaDRQAFHMEQLKYAEMRAR 946
Cdd:pfam02029 300 ---RKQEEAERKLREEEEKRR 317
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
1124-1201 |
8.61e-03 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 39.62 E-value: 8.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968347 1124 APGTIPPPNLPVSmANPLHPNLPATTTMPSSlplgpglgSAAAQSPAIVAAVQGNL------LPSASPLPDPGTPLPPDP 1197
Cdd:PRK10856 171 DPATTPAPAAPVD-TTPTNSQTPAVATAPAP--------AVDPQQNAVVAPSQANVdtaatpAPAAPATPDGAAPLPTDQ 241
|
....
gi 568968347 1198 TAPS 1201
Cdd:PRK10856 242 AGVS 245
|
|
| |
