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Conserved domains on  [gi|568967306|ref|XP_006513589|]
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centrosomal protein of 290 kDa isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CEP209_CC5 pfam16574
Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry ...
 1567-1694 3.20e-37

Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry a number of coiled-coil regions, and this is the fifth along the length of the protein. It is thought that the proteins are involved in cilia biosynthesis.


:

Pssm-ID: 465184 [Multi-domain]  Cd Length: 128  Bit Score: 137.52  E-value: 3.20e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1567 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKG 1646
Cdd:pfam16574    1 TMIQLQEDKAKLQEELKHAEEERRRAEDRAQELELKLKGLEELISTLKDGKGAQKVTEWHKKMEEIRLQELKLQRELSKQ 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568967306  1647 KEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELER 1694
Cdd:pfam16574   81 KEEIKYLENLIREQERTISSLEEEIVQQTKLHEERQLAWDQREVELER 128
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1360-2135 3.37e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.33  E-value: 3.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1360 HLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKavsdadRQRILELEKSEVELKVEVSKLREISDI 1439
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEEL------RLEVSELEEEIEELQKELYALANEISR 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1440 AKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKlhqhvvSLQISEATALGKLESVTSKLQKMEAYNLRLEQK 1519
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELA------ELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1520 LDEKEQALYYARlegrNRAKHLRQTIQSLRrqfsgalplAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEL 1599
Cdd:TIGR02168  374 LEELEEQLETLR----SKVAQLELQIASLN---------NEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1600 ELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHE 1679
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSG 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1680 ERQMAWDQREV----ELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLE---IALRKIKENIQVILKTQATC 1752
Cdd:TIGR02168  521 ILGVLSELISVdegyEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPldsIKGTEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1753 KSLEEKLKEKESALRLAEQNILSRDKVINELR--LRLPATADREKLIAELERKELEPKSHHTMKiAHQTIANMQARLNHK 1830
Cdd:TIGR02168  601 LGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDnaLELAKKLRPGYRIVTLDGDLVRPGGVITGG-SAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1831 EEVLKKYQHLLEKAREEQREIVkkheedlhvlhhKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAE 1910
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALA------------ELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE 747

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1911 QDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQEthasEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQK 1990
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA----QIEQLKEELKALREALDELRAELTLLNEEAANLR 823

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1991 E--ANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMtAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQ 2068
Cdd:TIGR02168  824 ErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI-EELESELEALLNERASLEEALALLRSELEELSEE 902

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967306  2069 IEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNK--------ILREKDGIDQENDELRRQIKRL 2135
Cdd:TIGR02168  903 LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEeysltleeAEALENKIEDDEEEARRRLKRL 977
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1901-2618 8.45e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.24  E-value: 8.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1901 LAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITEL--------------KVREFENTKLRLQ---ETHASEVKKVKA 1963
Cdd:TIGR02168  188 LDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelallvlrleelreELEELQEELKEAEeelEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1964 EVEDLRHALAQAHKDSQSLKSELQAQKEANSRaptttMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIA 2043
Cdd:TIGR02168  268 KLEELRLEVSELEEEIEELQKELYALANEISR-----LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2044 VTSQKEANLNVQQVVERHTrELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQ 2123
Cdd:TIGR02168  343 EEKLEELKEELESLEAELE-ELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2124 ENDELRRQIKRLSSGLQSKTLiDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEEL----IRWEEGKKWQTK 2199
Cdd:TIGR02168  422 EIEELLKKLEEAELKELQAEL-EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqARLDSLERLQEN 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2200 VEGLRNRLKEKEGEAHGLAKQLNTLKELF----------------------------AKADKEKLTLQKKLKTTGMTVDQ 2251
Cdd:TIGR02168  501 LEGFSEGVKALLKNQSGLSGILGVLSELIsvdegyeaaieaalggrlqavvvenlnaAKKAIAFLKQNELGRVTFLPLDS 580

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2252 VLGVRALESEKELEELKKKNLDLENDILYMRT------QQALPRDSVVEDL----HLQNKY-LQEKLHTLEKKL------ 2314
Cdd:TIGR02168  581 IKGTEIQGNDREILKNIEGFLGVAKDLVKFDPklrkalSYLLGGVLVVDDLdnalELAKKLrPGYRIVTLDGDLvrpggv 660

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2315 ----SKEKYSQSLTSEIESDDHCQK-------EQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKK 2383
Cdd:TIGR02168  661 itggSAKTNSSILERRREIEELEEKieeleekIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2384 GKLELERKLGQ-----VRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKAsgiltSEKMATIEEENRNLKAELEKL 2458
Cdd:TIGR02168  741 EVEQLEERIAQlskelTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-----KEELKALREALDELRAELTLL 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2459 KAHFGRQLSMQFESKNKGTEKIVaENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEG 2538
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAATER-RLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS 894

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2539 ADSKSWKSIvvsRVYETKMKELESDIAKKNQSITDLKQLVREAT-EREQKAKKYTEDLEQQIEILKNVPEGAETEQELIR 2617
Cdd:TIGR02168  895 ELEELSEEL---RELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR 971


                   .
gi 568967306  2618 E 2618
Cdd:TIGR02168  972 R 972
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 114-493 3.82e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.77  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   114 RDEIRQLEKQLEQKDRELEDMEKELdkekkvneqlalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGE 193
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKAL--------------AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   194 DSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEynrMKALVHQSDAVMDQIKKENEH 273
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE---LKALREALDELRAELTLLNEE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   274 YRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEwKLILSSKDDEIIEYQQMLQSLRGKLKNA--QLDADKSNIMALKQGIQ 351
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEEL-SEDIESLAAEIEELEELIEELESELEALlnERASLEEALALLRSELE 897

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   352 ERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQthymKIHSKVQILEEKTKEAERIAELAEADAREK 431
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE----RLSEEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568967306   432 DKELVEALKRLkdyesGVYGLeDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDE 493
Cdd:TIGR02168  974 LKRLENKIKEL-----GPVNL-AAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDRE 1029
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 846-1553 2.15e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.07  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   846 QRQLAFLRSQNETIVQDLpiQEEQSRNAELELDHQRSQAEQNEfLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQL 925
Cdd:TIGR02168  238 REELEELQEELKEAEEEL--EELTAELQELEEKLEELRLEVSE-LEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   926 EEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIfdaslHLKAQVDQLTGRNEELRQELRQSRKEAV 1005
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELE-----ELEAELEELESRLEELEEQLETLRSKVA 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1006 NYSQQLVKANLKIDHLEKE---TDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDS 1082
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARlerLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1083 LEDYNRKFAVIRHQQSLLYKEYLSEKDIwKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSR 1162
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERL-QENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQ 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1163 KITVLQVN---------EKSLIRQYTTLVEMERHLRKENGKHRNdviaMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDN 1233
Cdd:TIGR02168  549 AVVVENLNaakkaiaflKQNELGRVTFLPLDSIKGTEIQGNDRE----ILKNIEGFLGVAKDLVKFDPKLRKALSYLLGG 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1234 SVSLSELELANKQYNELTTKYRDI-----------------LQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITK 1296
Cdd:TIGR02168  625 VLVVDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1297 EKLHTIEQAWEQETKLGNDsnmdkakksmtnsdivsISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1376
Cdd:TIGR02168  705 KELEELEEELEQLRKELEE-----------------LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1377 TKFTELTKiNLDAQKVEQMLRDELADSVTKAVSdADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREK 1456
Cdd:TIGR02168  768 ERLEEAEE-ELAEAEAEIEELEAQIEQLKEELK-ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1457 EVESLRTQLLDFQAQ-SDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARL--- 1532
Cdd:TIGR02168  846 QIEELSEDIESLAAEiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREkla 925

                          730       740
                   ....*....|....*....|.
gi 568967306  1533 EGRNRAKHLRQTIQSLRRQFS 1553
Cdd:TIGR02168  926 QLELRLEGLEVRIDNLQERLS 946
 
Name Accession Description Interval E-value
CEP209_CC5 pfam16574
Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry ...
 1567-1694 3.20e-37

Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry a number of coiled-coil regions, and this is the fifth along the length of the protein. It is thought that the proteins are involved in cilia biosynthesis.


Pssm-ID: 465184 [Multi-domain]  Cd Length: 128  Bit Score: 137.52  E-value: 3.20e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1567 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKG 1646
Cdd:pfam16574    1 TMIQLQEDKAKLQEELKHAEEERRRAEDRAQELELKLKGLEELISTLKDGKGAQKVTEWHKKMEEIRLQELKLQRELSKQ 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568967306  1647 KEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELER 1694
Cdd:pfam16574   81 KEEIKYLENLIREQERTISSLEEEIVQQTKLHEERQLAWDQREVELER 128
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1360-2135 3.37e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.33  E-value: 3.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1360 HLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKavsdadRQRILELEKSEVELKVEVSKLREISDI 1439
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEEL------RLEVSELEEEIEELQKELYALANEISR 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1440 AKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKlhqhvvSLQISEATALGKLESVTSKLQKMEAYNLRLEQK 1519
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELA------ELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1520 LDEKEQALYYARlegrNRAKHLRQTIQSLRrqfsgalplAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEL 1599
Cdd:TIGR02168  374 LEELEEQLETLR----SKVAQLELQIASLN---------NEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1600 ELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHE 1679
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSG 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1680 ERQMAWDQREV----ELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLE---IALRKIKENIQVILKTQATC 1752
Cdd:TIGR02168  521 ILGVLSELISVdegyEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPldsIKGTEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1753 KSLEEKLKEKESALRLAEQNILSRDKVINELR--LRLPATADREKLIAELERKELEPKSHHTMKiAHQTIANMQARLNHK 1830
Cdd:TIGR02168  601 LGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDnaLELAKKLRPGYRIVTLDGDLVRPGGVITGG-SAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1831 EEVLKKYQHLLEKAREEQREIVkkheedlhvlhhKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAE 1910
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALA------------ELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE 747

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1911 QDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQEthasEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQK 1990
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA----QIEQLKEELKALREALDELRAELTLLNEEAANLR 823

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1991 E--ANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMtAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQ 2068
Cdd:TIGR02168  824 ErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI-EELESELEALLNERASLEEALALLRSELEELSEE 902

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967306  2069 IEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNK--------ILREKDGIDQENDELRRQIKRL 2135
Cdd:TIGR02168  903 LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEeysltleeAEALENKIEDDEEEARRRLKRL 977
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1901-2618 8.45e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.24  E-value: 8.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1901 LAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITEL--------------KVREFENTKLRLQ---ETHASEVKKVKA 1963
Cdd:TIGR02168  188 LDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelallvlrleelreELEELQEELKEAEeelEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1964 EVEDLRHALAQAHKDSQSLKSELQAQKEANSRaptttMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIA 2043
Cdd:TIGR02168  268 KLEELRLEVSELEEEIEELQKELYALANEISR-----LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2044 VTSQKEANLNVQQVVERHTrELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQ 2123
Cdd:TIGR02168  343 EEKLEELKEELESLEAELE-ELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2124 ENDELRRQIKRLSSGLQSKTLiDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEEL----IRWEEGKKWQTK 2199
Cdd:TIGR02168  422 EIEELLKKLEEAELKELQAEL-EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqARLDSLERLQEN 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2200 VEGLRNRLKEKEGEAHGLAKQLNTLKELF----------------------------AKADKEKLTLQKKLKTTGMTVDQ 2251
Cdd:TIGR02168  501 LEGFSEGVKALLKNQSGLSGILGVLSELIsvdegyeaaieaalggrlqavvvenlnaAKKAIAFLKQNELGRVTFLPLDS 580

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2252 VLGVRALESEKELEELKKKNLDLENDILYMRT------QQALPRDSVVEDL----HLQNKY-LQEKLHTLEKKL------ 2314
Cdd:TIGR02168  581 IKGTEIQGNDREILKNIEGFLGVAKDLVKFDPklrkalSYLLGGVLVVDDLdnalELAKKLrPGYRIVTLDGDLvrpggv 660

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2315 ----SKEKYSQSLTSEIESDDHCQK-------EQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKK 2383
Cdd:TIGR02168  661 itggSAKTNSSILERRREIEELEEKieeleekIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2384 GKLELERKLGQ-----VRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKAsgiltSEKMATIEEENRNLKAELEKL 2458
Cdd:TIGR02168  741 EVEQLEERIAQlskelTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-----KEELKALREALDELRAELTLL 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2459 KAHFGRQLSMQFESKNKGTEKIVaENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEG 2538
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAATER-RLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS 894

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2539 ADSKSWKSIvvsRVYETKMKELESDIAKKNQSITDLKQLVREAT-EREQKAKKYTEDLEQQIEILKNVPEGAETEQELIR 2617
Cdd:TIGR02168  895 ELEELSEEL---RELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR 971


                   .
gi 568967306  2618 E 2618
Cdd:TIGR02168  972 R 972
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1911-2192 2.32e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1911 QDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQK 1990
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1991 EANSRAptttmrnlvDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAvtsqKEANLNVQQVVERHTRELKSQIE 2070
Cdd:COG1196   313 ELEERL---------EELEEELAELEEELEELEEELEELEEELEEAEEELEEA----EAELAEAEEALLEAEAELAEAEE 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2071 DLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQS 2150
Cdd:COG1196   380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568967306 2151 LIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEE 2192
Cdd:COG1196   460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 114-493 3.82e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.77  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   114 RDEIRQLEKQLEQKDRELEDMEKELdkekkvneqlalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGE 193
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKAL--------------AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   194 DSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEynrMKALVHQSDAVMDQIKKENEH 273
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE---LKALREALDELRAELTLLNEE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   274 YRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEwKLILSSKDDEIIEYQQMLQSLRGKLKNA--QLDADKSNIMALKQGIQ 351
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEEL-SEDIESLAAEIEELEELIEELESELEALlnERASLEEALALLRSELE 897

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   352 ERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQthymKIHSKVQILEEKTKEAERIAELAEADAREK 431
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE----RLSEEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568967306   432 DKELVEALKRLkdyesGVYGLeDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDE 493
Cdd:TIGR02168  974 LKRLENKIKEL-----GPVNL-AAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDRE 1029
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 846-1553 2.15e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.07  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   846 QRQLAFLRSQNETIVQDLpiQEEQSRNAELELDHQRSQAEQNEfLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQL 925
Cdd:TIGR02168  238 REELEELQEELKEAEEEL--EELTAELQELEEKLEELRLEVSE-LEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   926 EEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIfdaslHLKAQVDQLTGRNEELRQELRQSRKEAV 1005
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELE-----ELEAELEELESRLEELEEQLETLRSKVA 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1006 NYSQQLVKANLKIDHLEKE---TDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDS 1082
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARlerLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1083 LEDYNRKFAVIRHQQSLLYKEYLSEKDIwKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSR 1162
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERL-QENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQ 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1163 KITVLQVN---------EKSLIRQYTTLVEMERHLRKENGKHRNdviaMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDN 1233
Cdd:TIGR02168  549 AVVVENLNaakkaiaflKQNELGRVTFLPLDSIKGTEIQGNDRE----ILKNIEGFLGVAKDLVKFDPKLRKALSYLLGG 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1234 SVSLSELELANKQYNELTTKYRDI-----------------LQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITK 1296
Cdd:TIGR02168  625 VLVVDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1297 EKLHTIEQAWEQETKLGNDsnmdkakksmtnsdivsISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1376
Cdd:TIGR02168  705 KELEELEEELEQLRKELEE-----------------LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1377 TKFTELTKiNLDAQKVEQMLRDELADSVTKAVSdADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREK 1456
Cdd:TIGR02168  768 ERLEEAEE-ELAEAEAEIEELEAQIEQLKEELK-ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1457 EVESLRTQLLDFQAQ-SDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARL--- 1532
Cdd:TIGR02168  846 QIEELSEDIESLAAEiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREkla 925

                          730       740
                   ....*....|....*....|.
gi 568967306  1533 EGRNRAKHLRQTIQSLRRQFS 1553
Cdd:TIGR02168  926 QLELRLEGLEVRIDNLQERLS 946
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 113-575 4.17e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRG 192
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  193 EDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENE 272
Cdd:COG1196   324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  273 HYRLQVRELTDLLKAKDEEddpvmmavnakVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDAdKSNIMALKQGIQE 352
Cdd:COG1196   404 ELEEAEEALLERLERLEEE-----------LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE-EALLELLAELLEE 471

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  353 RDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADA---- 428
Cdd:COG1196   472 AALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  429 -REKDKELVEALKRLKDYESG-------------------------VYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINK 482
Cdd:COG1196   552 vVEDDEVAAAAIEYLKAAKAGratflpldkiraraalaaalargaiGAAVDLVASDLREADARYYVLGDTLLGRTLVAAR 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  483 LEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNA 562
Cdd:COG1196   632 LEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                         490
                  ....*....|...
gi 568967306  563 ASGLTIDDLNLSE 575
Cdd:COG1196   712 AEEERLEEELEEE 724
PTZ00121 PTZ00121
MAEBL; Provisional
 2016-2729 1.13e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2016 EKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQvvERHTRELKSQIEDLNENLLKLKEALKTS-----KNKE 2090
Cdd:PTZ00121 1236 KKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEE--ARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEE 1313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2091 NSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSliDELQKKVKKLESQLE--R 2168
Cdd:PTZ00121 1314 AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKK--EEAKKKADAAKKKAEekK 1391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2169 KVDDVDIKPVKEKSSKEELIRWEEGKKwqtkveglrnrlkeKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMT 2248
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKKAAAAKK--------------KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK 1457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2249 VDQVLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKE---KYSQSLTS 2325
Cdd:PTZ00121 1458 KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEakkAEEAKKAD 1537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2326 EIESDDHCQKEQELQK-ENLKLSSE--NIELKFQLEQANKDLPRLKNQVKDLKE--MCEFLKKGKLELERKLGQVRGAGR 2400
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKaEELKKAEEkkKAEEAKKAEEDKNMALRKAEEAKKAEEarIEEVMKLYEEEKKMKAEEAKKAEE 1617

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2401 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAhfgRQLSMQFESKNKGTEKI 2480
Cdd:PTZ00121 1618 AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKA---EEAKKAEEDEKKAAEAL 1694

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2481 VAENERLRK-ELKKEIEASEKlriaknnlelvndKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKE 2559
Cdd:PTZ00121 1695 KKEAEEAKKaEELKKKEAEEK-------------KKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAH 1761

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2560 LESDIAKKNQSITDLKQLV------REATEREQKAKKYTEDLEQQIEIL-----KNVPEGAETEQELIRELQLLRLANNq 2628
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVieeeldEEDEKRRMEVDKKIKDIFDNFANIieggkEGNLVINDSKEMEDSAIKEVADSKN- 1840

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2629 MDKERAELIHQIEINKDQTRADSSIPDSDQLKEKIN--DLETQLRKLELEKQHSkEEVKKLKKELENFDPSFFEEIEDlK 2706
Cdd:PTZ00121 1841 MQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLkeDDEEEIEEADEIEKID-KDDIEREIPNNNMAGKNNDIIDD-K 1918

                         730       740
                  ....*....|....*....|....
gi 568967306 2707 YNYKEEVKKNI-LLEEKLKKLSEQ 2729
Cdd:PTZ00121 1919 LDKDEYIKRDAeETREEIIKISKK 1942
PRK11281 PRK11281
mechanosensitive channel MscK;
1913-2165 1.83e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 53.76  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1913 DSLSSLLTKLKKvSKDLEKQKEITelkVREFENTKLRLQEThasevKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEA 1992
Cdd:PRK11281   39 ADVQAQLDALNK-QKLLEAEDKLV---QQDLEQTLALLDKI-----DRQKEETEQLKQQLAQAPAKLRQAQAELEALKDD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1993 NSRAPTTTMRNL-VDRLKSQLALKEKQQKALSRALLELRSEMTAA--AEERiiavtSQKEANLNVQQvverhTRELKSQI 2069
Cdd:PRK11281  110 NDEETRETLSTLsLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLqtQPER-----AQAALYANSQR-----LQQIRNLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2070 EDLNENLLKLKEALKTSKNKENSLADdlneLNNELQKKQKAYNKILreKDGIDQENDELRRQIKRLSSGLQS-KTLIDNK 2148
Cdd:PRK11281  180 KGGKVGGKALRPSQRVLLQAEQALLN----AQNDLQRKSLEGNTQL--QDLLQKQRDYLTARIQRLEHQLQLlQEAINSK 253

                         250
                  ....*....|....*..
gi 568967306 2149 QslIDELQKKVKKLESQ 2165
Cdd:PRK11281  254 R--LTLSEKTVQEAQSQ 268
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2008-2674 2.51e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2008 LKSQLALKEKQQKALSRALlELRSEmtaaAEERiiavtsQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSK 2087
Cdd:COG1196   198 LERQLEPLERQAEKAERYR-ELKEE----LKEL------EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2088 NKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLssglqsktlidnkQSLIDELQKKVKKLESQLE 2167
Cdd:COG1196   267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------------EERLEELEEELAELEEELE 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2168 RKvddvdikpvkekssKEELIRWEEgkkwqtkveglrnRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKklkttgm 2247
Cdd:COG1196   334 EL--------------EEELEELEE-------------ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE------- 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2248 tvdqvlgvRALESEKELEELKKKNLDLENDILYMRTQQAlprdsvvEDLHLQNKYLQEKLhtlekklskEKYSQSLTSEI 2327
Cdd:COG1196   380 --------ELEELAEELLEALRAAAELAAQLEELEEAEE-------ALLERLERLEEELE---------ELEEALAELEE 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2328 ESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPE 2407
Cdd:COG1196   436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2408 LEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSmqFESKNK-GTEKIVAENER 2486
Cdd:COG1196   516 LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRAT--FLPLDKiRARAALAAALA 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2487 LRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSrvyETKMKELESDIAK 2566
Cdd:COG1196   594 RGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGS---AGGSLTGGSRREL 670

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2567 KNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKnvpEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQ 2646
Cdd:COG1196   671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEER---ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEEL 747

                         650       660       670
                  ....*....|....*....|....*....|...
gi 568967306 2647 TRAD-----SSIPDSDQLKEKINDLETQLRKLE 2674
Cdd:COG1196   748 LEEEaleelPEPPDLEELERELERLEREIEALG 780
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
87-563 4.01e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.76  E-value: 4.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   87 LKTKVMKLENELEMAQQSAGGrdtrfLRDEIRQLEKQLEQKDRELEDME------KELDKEKKVNEQLALRNEEAENENS 160
Cdd:PRK03918  236 LKEEIEELEKELESLEGSKRK-----LEEKIRELEERIEELKKEIEELEekvkelKELKEKAEEYIKLSEFYEEYLDELR 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  161 KLRRENEQLRQDIIDYQKQIdSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLT---------------EANEKI 225
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERI-KELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKakkeelerlkkrltgLTPEKL 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  226 EVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTdllkakdEEDDPVMMavnakvEE 305
Cdd:PRK03918  390 EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT-------EEHRKELL------EE 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  306 WKLILSSKDDEIIEYQQMLQSLRGKLKNAQ-LDADKSNIMALKQGIQerdsQIKMLTEQVEQYTKE-MEKNTFIIEDLKN 383
Cdd:PRK03918  457 YTAELKRIEKELKEIEEKERKLRKELRELEkVLKKESELIKLKELAE----QLKELEEKLKKYNLEeLEKKAEEYEKLKE 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  384 ELQKDKGtsnfyQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVE-ALKRLKDYESGVYGLEDA---VIEI 459
Cdd:PRK03918  533 KLIKLKG-----EIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEElGFESVEELEERLKELEPFyneYLEL 607

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  460 KNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGlEPKTMIDLTEFRNsKRLKQQQYRAENQVLLKEIESL 539
Cdd:PRK03918  608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE-ELEKKYSEEEYEE-LREEYLELSRELAGLRAELEEL 685

                         490       500
                  ....*....|....*....|....
gi 568967306  540 EEERLDLKRKIRQMAQERGKRNAA 563
Cdd:PRK03918  686 EKRREEIKKTLEKLKEELEEREKA 709
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1836-2240 5.03e-06

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 52.07  E-value: 5.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1836 KYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADnslnKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVA------ 1909
Cdd:pfam09731   31 NFRDFFEEYIPYGEEVVLYALGEDPPLAPKPKTFRP----LQPSVVSAVTGESKEPKEEKKQVKIPRQSGVSSEvaeeek 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1910 -EQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQA 1988
Cdd:pfam09731  107 eATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQ 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1989 QKEANSRAPTTTM----RNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVerhtRE 2064
Cdd:pfam09731  187 KAEALAEKLKEVInlakQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQ----QE 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2065 LKSQIEDLNENLlklKEALKTSKNKENSLAD----DLNELNNELQKKQKAYNKilREKDGIDQENDELRRQIKRLSSGLQ 2140
Cdd:pfam09731  263 LVSIFPDIIPVL---KEDNLLSNDDLNSLIAhahrEIDQLSKKLAELKKREEK--HIERALEKQKEELDKLAEELSARLE 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2141 SKTLIDNKQsLIDELQKKVK--------KLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEG 2212
Cdd:pfam09731  338 EVRAADEAQ-LRLEFEREREeiresyeeKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEERAGRLLKLN 416

                          410       420
                   ....*....|....*....|....*...
gi 568967306  2213 EAHGLAKQLNTLKELFAKADKEKLTLQK 2240
Cdd:pfam09731  417 ELLANLKGLEKATSSHSEVEDENRKAQQ 444
PTZ00121 PTZ00121
MAEBL; Provisional
 1067-1651 2.76e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1067 QELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLED--QAEQDAVKVKEYNNLLS 1144
Cdd:PTZ00121 1246 EEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEakKKAEEAKKADEAKKKAE 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1145 ALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMER--HLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIF 1222
Cdd:PTZ00121 1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEaaEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKK 1405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1223 KIAALQKVidnsvslselELANKQYNELTTKYRDILQKDnmlvqrtsnlehlecenaSLKEQMEAISKELEItKEKLHTI 1302
Cdd:PTZ00121 1406 KADELKKA----------AAAKKKADEAKKKAEEKKKAD------------------EAKKKAEEAKKADEA-KKKAEEA 1456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1303 EQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSlkqmEERNFELETKFTEL 1382
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKA----EEAKKADEAKKAEE 1532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1383 TKINLDAQKVEQMLRdelADSVTKAVsdadrqrilELEKSEVELKVE-VSKLREISDIAKRQVDFLNSQQQSREKEVESL 1461
Cdd:PTZ00121 1533 AKKADEAKKAEEKKK---ADELKKAE---------ELKKAEEKKKAEeAKKAEEDKNMALRKAEEAKKAEEARIEEVMKL 1600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1462 RTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL 1541
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA 1680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1542 RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRnmeNKTLELELKLKGLEELISTLKDARGAQK 1621
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENK---IKAEEAKKEAEEDKKKAEEAKKDEEEKK 1757

                         570       580       590
                  ....*....|....*....|....*....|
gi 568967306 1622 VINWHVKIEELRLQELKLNRELVKgKEEIK 1651
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEIRKEKEAVI-EEELD 1786
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 52-252 1.12e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 44.25  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    52 FRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ-----LKTKVMKLENELEMAQQsaggrDTRFLRDEIRQLEKQLEQ 126
Cdd:pfam05667  300 FTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREeeleeLQEQLEDLESSIQELEK-----EIKKLESSIKQVEEELEE 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   127 KDRELEDMEKELDKEKKVNEQLalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSrrgEDSDYRSQLSKKNY 206
Cdd:pfam05667  375 LKEQNEELEKQYKVKKKTLDLL----PDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIE---EYRALKEAKSNKED 447

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 568967306   207 ELVQYLDEIQTLteaNEKIEVQNQEMRKNLEESVQ---EMEKMTDEYNR 252
Cdd:pfam05667  448 ESQRKLEEIKEL---REKIKEVAEEAKQKEELYKQlvaEYERLPKDVSR 493
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 867-1191 2.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  867 EEQSRNAE--LELDHQRSQAEQNEFLsRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSD 944
Cdd:COG1196   206 ERQAEKAEryRELKEELKELEAELLL-LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  945 VKGGETSLIIPSLERLVNAMEsknaegifdaslHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKE 1024
Cdd:COG1196   285 EAQAEEYELLAELARLEQDIA------------RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEE 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1025 TDLLRQSagsnvvykgidlpdgiapssayiinsqneyLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEY 1104
Cdd:COG1196   353 LEEAEAE------------------------------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1105 LSEkdiwKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEM 1184
Cdd:COG1196   403 EEL----EEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478


                  ....*..
gi 568967306 1185 ERHLRKE 1191
Cdd:COG1196   479 LAELLEE 485
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 2016-2527 5.10e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.42  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2016 EKQQKALS--RALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVER-HTRE--LKSQIEDLNENLLKLKEALKTSKNKE 2090
Cdd:pfam05557   17 EKKQMELEhkRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKReAEAEeaLREQAELNRLKKKYLEALNKKLNEKE 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2091 NSLAD----------DLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSktlIDNKQSLIDELQKKVK 2160
Cdd:pfam05557   97 SQLADarevisclknELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN---LEKQQSSLAEAEQRIK 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2161 KLESQLERKVDDVDIKpvkeKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEG-------EAHGLAKQLNTLKELFAKADK 2233
Cdd:pfam05557  174 ELEFEIQSQEQDSEIV----KNSKSELARIPELEKELERLREHNKHLNENIEnklllkeEVEDLKRKLEREEKYREEAAT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2234 ---EKLTLQKKLK-------TTGMTV----------------DQVLGVRALESEKELEELKKKNLDLENDILYMRtQQAL 2287
Cdd:pfam05557  250 lelEKEKLEQELQswvklaqDTGLNLrspedlsrrieqlqqrEIVLKEENSSLTSSARQLEKARRELEQELAQYL-KKIE 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2288 PRDSVVEDLHLQNKYLQEKLHTLEK-----KLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANK 2362
Cdd:pfam05557  329 DLNKKLKRHKALVRRLQRRVLLLTKerdgyRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEE 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2363 dlprlknQVKDLKEMCEFLKKgKLELERKLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKkasgiltsekma 2442
Cdd:pfam05557  409 -------ELGGYKQQAQTLER-ELQALRQQESLADPSYSKEEVDSLRRKLETLELERQRLREQKNELE------------ 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2443 tIEEENRNLKAELE----KLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDK---- 2514
Cdd:pfam05557  469 -MELERRCLQGDYDpkktKVLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKevld 547

                          570
                   ....*....|...
gi 568967306  2515 MAAQLEETGKRLQ 2527
Cdd:pfam05557  548 LRKELESAELKNQ 560
 
Name Accession Description Interval E-value
CEP209_CC5 pfam16574
Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry ...
 1567-1694 3.20e-37

Coiled-coil region of centrosome protein CE290; CEP290 and similar centrosomal proteins carry a number of coiled-coil regions, and this is the fifth along the length of the protein. It is thought that the proteins are involved in cilia biosynthesis.


Pssm-ID: 465184 [Multi-domain]  Cd Length: 128  Bit Score: 137.52  E-value: 3.20e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1567 TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKG 1646
Cdd:pfam16574    1 TMIQLQEDKAKLQEELKHAEEERRRAEDRAQELELKLKGLEELISTLKDGKGAQKVTEWHKKMEEIRLQELKLQRELSKQ 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 568967306  1647 KEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELER 1694
Cdd:pfam16574   81 KEEIKYLENLIREQERTISSLEEEIVQQTKLHEERQLAWDQREVELER 128
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1360-2135 3.37e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.33  E-value: 3.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1360 HLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKavsdadRQRILELEKSEVELKVEVSKLREISDI 1439
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEEL------RLEVSELEEEIEELQKELYALANEISR 299

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1440 AKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKlhqhvvSLQISEATALGKLESVTSKLQKMEAYNLRLEQK 1519
Cdd:TIGR02168  300 LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELA------ELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1520 LDEKEQALYYARlegrNRAKHLRQTIQSLRrqfsgalplAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEL 1599
Cdd:TIGR02168  374 LEELEEQLETLR----SKVAQLELQIASLN---------NEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1600 ELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHE 1679
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSG 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1680 ERQMAWDQREV----ELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPNQLE---IALRKIKENIQVILKTQATC 1752
Cdd:TIGR02168  521 ILGVLSELISVdegyEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPldsIKGTEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1753 KSLEEKLKEKESALRLAEQNILSRDKVINELR--LRLPATADREKLIAELERKELEPKSHHTMKiAHQTIANMQARLNHK 1830
Cdd:TIGR02168  601 LGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDnaLELAKKLRPGYRIVTLDGDLVRPGGVITGG-SAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1831 EEVLKKYQHLLEKAREEQREIVkkheedlhvlhhKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAE 1910
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALA------------ELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE 747

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1911 QDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQEthasEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQK 1990
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA----QIEQLKEELKALREALDELRAELTLLNEEAANLR 823

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1991 E--ANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMtAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQ 2068
Cdd:TIGR02168  824 ErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI-EELESELEALLNERASLEEALALLRSELEELSEE 902

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967306  2069 IEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNK--------ILREKDGIDQENDELRRQIKRL 2135
Cdd:TIGR02168  903 LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEeysltleeAEALENKIEDDEEEARRRLKRL 977
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1901-2618 8.45e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 71.24  E-value: 8.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1901 LAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITEL--------------KVREFENTKLRLQ---ETHASEVKKVKA 1963
Cdd:TIGR02168  188 LDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelallvlrleelreELEELQEELKEAEeelEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1964 EVEDLRHALAQAHKDSQSLKSELQAQKEANSRaptttMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIA 2043
Cdd:TIGR02168  268 KLEELRLEVSELEEEIEELQKELYALANEISR-----LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2044 VTSQKEANLNVQQVVERHTrELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQ 2123
Cdd:TIGR02168  343 EEKLEELKEELESLEAELE-ELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2124 ENDELRRQIKRLSSGLQSKTLiDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEEL----IRWEEGKKWQTK 2199
Cdd:TIGR02168  422 EIEELLKKLEEAELKELQAEL-EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqARLDSLERLQEN 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2200 VEGLRNRLKEKEGEAHGLAKQLNTLKELF----------------------------AKADKEKLTLQKKLKTTGMTVDQ 2251
Cdd:TIGR02168  501 LEGFSEGVKALLKNQSGLSGILGVLSELIsvdegyeaaieaalggrlqavvvenlnaAKKAIAFLKQNELGRVTFLPLDS 580

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2252 VLGVRALESEKELEELKKKNLDLENDILYMRT------QQALPRDSVVEDL----HLQNKY-LQEKLHTLEKKL------ 2314
Cdd:TIGR02168  581 IKGTEIQGNDREILKNIEGFLGVAKDLVKFDPklrkalSYLLGGVLVVDDLdnalELAKKLrPGYRIVTLDGDLvrpggv 660

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2315 ----SKEKYSQSLTSEIESDDHCQK-------EQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKK 2383
Cdd:TIGR02168  661 itggSAKTNSSILERRREIEELEEKieeleekIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2384 GKLELERKLGQ-----VRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKAsgiltSEKMATIEEENRNLKAELEKL 2458
Cdd:TIGR02168  741 EVEQLEERIAQlskelTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL-----KEELKALREALDELRAELTLL 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2459 KAHFGRQLSMQFESKNKGTEKIVaENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEG 2538
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAATER-RLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS 894

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2539 ADSKSWKSIvvsRVYETKMKELESDIAKKNQSITDLKQLVREAT-EREQKAKKYTEDLEQQIEILKNVPEGAETEQELIR 2617
Cdd:TIGR02168  895 ELEELSEEL---RELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR 971


                   .
gi 568967306  2618 E 2618
Cdd:TIGR02168  972 R 972
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1923-2278 1.39e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 1.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1923 KKVSKDLEKQKEITELKvREFENTKLRLQETHAsEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEansraptttmr 2002
Cdd:TIGR02168  667 KTNSSILERRREIEELE-EKIEELEEKIAELEK-ALAELRKELEELEEELEQLRKELEELSRQISALRK----------- 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2003 nLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAvtsqkeanlnvqqvvERHTRELKSQIEDLNENLLKLKEA 2082
Cdd:TIGR02168  734 -DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEA---------------EEELAEAEAEIEELEAQIEQLKEE 797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2083 LKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLidnkqsLIDELQKKVKKL 2162
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAA------EIEELEELIEEL 871

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2163 ESQLERKVDDVDIKPVKEKSSKEELIrweegkKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKL 2242
Cdd:TIGR02168  872 ESELEALLNERASLEEALALLRSELE------ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 568967306  2243 KTTGMTVDQVLGVRALESEKELEELKKKNLDLENDI 2278
Cdd:TIGR02168  946 SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKI 981
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1835-2706 4.97e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.46  E-value: 4.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1835 KKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQAdNSLNKFRQTAQDLLKQSPAPVPTNKHFIRlaEMEQTVAEQDDS 1914
Cdd:TIGR02168  213 ERYKELKAELRELELALLVLRLEELREELEELQEEL-KEAEEELEELTAELQELEEKLEELRLEVS--ELEEEIEELQKE 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1915 LSSLLTKLKkvskDLEKQKEITELKVREFENTKLRLQEthasEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANS 1994
Cdd:TIGR02168  290 LYALANEIS----RLEQQKQILRERLANLERQLEELEA----QLEELESKLDELAEELAELEEKLEELKEELESLEAELE 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1995 RAptttmRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQvverhtreLKSQIEDLNE 2074
Cdd:TIGR02168  362 EL-----EAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRER--------LQQEIEELLK 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2075 NLLKLKeaLKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDE 2154
Cdd:TIGR02168  429 KLEEAE--LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSE 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2155 LQKKVKKLESQLERKVDDVdikpvkeksskEELIRWEEGkkWQTKVE-GLRNRL-------KEKEGEAHGLAKQLNTLKE 2226
Cdd:TIGR02168  507 GVKALLKNQSGLSGILGVL-----------SELISVDEG--YEAAIEaALGGRLqavvvenLNAAKKAIAFLKQNELGRV 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2227 LFAKADKEKLT-LQKKLKTTGMTVDQVLGVralesekeLEELKKKNLDLENDILYMrTQQALPRDSVVEDLHLQNKY-LQ 2304
Cdd:TIGR02168  574 TFLPLDSIKGTeIQGNDREILKNIEGFLGV--------AKDLVKFDPKLRKALSYL-LGGVLVVDDLDNALELAKKLrPG 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2305 EKLHTLEKKLSKEKYSQSLTSEIESddhcQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKG 2384
Cdd:TIGR02168  645 YRIVTLDGDLVRPGGVITGGSAKTN----SSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKE 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2385 KLELERKLGQVR-GAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKmATIEEENRNLKAELEKLKahfg 2463
Cdd:TIGR02168  721 LEELSRQISALRkDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL-AEAEAEIEELEAQIEQLK---- 795

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2464 rqlsmqfESKNKGTEKIVAENERLRKelkkeieasekLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKs 2543
Cdd:TIGR02168  796 -------EELKALREALDELRAELTL-----------LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES- 856

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2544 wksivvsrvYETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEilknvpEGAETEQELIRELQLLR 2623
Cdd:TIGR02168  857 ---------LAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELR------ELESKRSELRRELEELR 921

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2624 LANNQMDKERAELIHQIEINKDQTRADSSIPdsdqlkekINDLETQLRKLELEKQHSKEEVKKLKKELENFDPSFFEEIE 2703
Cdd:TIGR02168  922 EKLAQLELRLEGLEVRIDNLQERLSEEYSLT--------LEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIE 993


                   ...
gi 568967306  2704 DLK 2706
Cdd:TIGR02168  994 EYE 996
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1911-2192 2.32e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1911 QDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQK 1990
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1991 EANSRAptttmrnlvDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAvtsqKEANLNVQQVVERHTRELKSQIE 2070
Cdd:COG1196   313 ELEERL---------EELEEELAELEEELEELEEELEELEEELEEAEEELEEA----EAELAEAEEALLEAEAELAEAEE 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2071 DLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQS 2150
Cdd:COG1196   380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568967306 2151 LIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEE 2192
Cdd:COG1196   460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 114-493 3.82e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.77  E-value: 3.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   114 RDEIRQLEKQLEQKDRELEDMEKELdkekkvneqlalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGE 193
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKAL--------------AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   194 DSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEynrMKALVHQSDAVMDQIKKENEH 273
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE---LKALREALDELRAELTLLNEE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   274 YRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEwKLILSSKDDEIIEYQQMLQSLRGKLKNA--QLDADKSNIMALKQGIQ 351
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEEL-SEDIESLAAEIEELEELIEELESELEALlnERASLEEALALLRSELE 897

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   352 ERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQthymKIHSKVQILEEKTKEAERIAELAEADAREK 431
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE----RLSEEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568967306   432 DKELVEALKRLkdyesGVYGLeDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDE 493
Cdd:TIGR02168  974 LKRLENKIKEL-----GPVNL-AAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDRE 1029
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 114-452 6.48e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 6.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   114 RDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQL----ALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLS 189
Cdd:TIGR02169  176 LEELEEVEENIERLDLIIDEKRQQLERLRREREKAeryqALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEK 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   190 RRGEDSDYRSQLSKKNYELVQYLDEIQTLTEAN--------EKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSD 261
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEqlrvkekiGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   262 AVMDQIKKENEHYRLQVRELTDLLKA-KDEEDDPV--MMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDA 338
Cdd:TIGR02169  336 AEIEELEREIEEERKRRDKLTEEYAElKEELEDLRaeLEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEEL 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   339 DK--SNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKdkgtsnfYQQTHYmKIHSKVQILEEKTKE 416
Cdd:TIGR02169  416 QRlsEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSK-------YEQELY-DLKEEYDRVEKELSK 487

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 568967306   417 AERIAELAEADAR---EKDKELVEALKRLKDYESGVYGL 452
Cdd:TIGR02169  488 LQRELAEAEAQARaseERVRGGRAVEEVLKASIQGVHGT 526
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2063-2729 8.03e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 61.61  E-value: 8.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2063 RELKSQIEDLNENLLKLKEALKTSKNKENSL------ADDLNELNNELQKKQKAYnkILREKDGIDQENDELRRQIKRLS 2136
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLerqaekAERYKELKAELRELELAL--LVLRLEELREELEELQEELKEAE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2137 SGLQS-KTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKpVKEKSSKEELIRweegkKWQTKVEGLRNRLKEKEGEAH 2215
Cdd:TIGR02168  253 EELEElTAELQELEEKLEELRLEVSELEEEIEELQKELYAL-ANEISRLEQQKQ-----ILRERLANLERQLEELEAQLE 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2216 GLAKQLNTLKELFAKADKEKLTLQKKLKTtgmtvdqvLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVvED 2295
Cdd:TIGR02168  327 ELESKLDELAEELAELEEKLEELKEELES--------LEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQI-AS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2296 LHLQNKYLQEKLHTLEKKLSKEKYSQSL----TSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQV 2371
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEEllkkLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAL 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2372 KDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRN- 2450
Cdd:TIGR02168  478 DAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAVVVENLNa 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2451 LKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKE------LKKEIEASEKLRIAKNNLeLVNDKMAAQLE---E 2521
Cdd:TIGR02168  558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIegflgvAKDLVKFDPKLRKALSYL-LGGVLVVDDLDnalE 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2522 TGKRLQFAE----------SRAPQLEGADSKSWKSIVVSRV----YETKMKELESDIAKKNQSITDLKQLVREATEREQK 2587
Cdd:TIGR02168  637 LAKKLRPGYrivtldgdlvRPGGVITGGSAKTNSSILERRReieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2588 AKKYTEDLEQQIEILKNVPEGAETEQELIRE-LQLLRLANNQMDKERAELIHQIEINKDQTRADSSipDSDQLKEKINDL 2666
Cdd:TIGR02168  717 LRKELEELSRQISALRKDLARLEAEVEQLEErIAQLSKELTELEAEIEELEERLEEAEEELAEAEA--EIEELEAQIEQL 794

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568967306  2667 ETQLRKL-----ELEKQHSKEEVKKLKKElenfdpsffEEIEDLKYNYKEEVKKNILLEEKLKKLSEQ 2729
Cdd:TIGR02168  795 KEELKALrealdELRAELTLLNEEAANLR---------ERLESLERRIAATERRLEDLEEQIEELSED 853
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 93-387 1.29e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    93 KLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQD 172
Cdd:TIGR02168  217 ELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   173 IIDYQKQIDSQKESLlsrrgedSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNR 252
Cdd:TIGR02168  297 ISRLEQQKQILRERL-------ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   253 MKALVHQSDAVMDQIKKENEHYRLQVRELtdllkakdeeddpvmmavNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLK 332
Cdd:TIGR02168  370 LESRLEELEEQLETLRSKVAQLELQIASL------------------NNEIERLEARLERLEDRRERLQQEIEELLKKLE 431

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568967306   333 NAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQK 387
Cdd:TIGR02168  432 EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQ 486
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 846-1553 2.15e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.07  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   846 QRQLAFLRSQNETIVQDLpiQEEQSRNAELELDHQRSQAEQNEfLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQL 925
Cdd:TIGR02168  238 REELEELQEELKEAEEEL--EELTAELQELEEKLEELRLEVSE-LEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   926 EEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIfdaslHLKAQVDQLTGRNEELRQELRQSRKEAV 1005
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELE-----ELEAELEELESRLEELEEQLETLRSKVA 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1006 NYSQQLVKANLKIDHLEKE---TDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDS 1082
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARlerLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1083 LEDYNRKFAVIRHQQSLLYKEYLSEKDIwKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSR 1162
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERL-QENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQ 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1163 KITVLQVN---------EKSLIRQYTTLVEMERHLRKENGKHRNdviaMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDN 1233
Cdd:TIGR02168  549 AVVVENLNaakkaiaflKQNELGRVTFLPLDSIKGTEIQGNDRE----ILKNIEGFLGVAKDLVKFDPKLRKALSYLLGG 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1234 SVSLSELELANKQYNELTTKYRDI-----------------LQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITK 1296
Cdd:TIGR02168  625 VLVVDDLDNALELAKKLRPGYRIVtldgdlvrpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1297 EKLHTIEQAWEQETKLGNDsnmdkakksmtnsdivsISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1376
Cdd:TIGR02168  705 KELEELEEELEQLRKELEE-----------------LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1377 TKFTELTKiNLDAQKVEQMLRDELADSVTKAVSdADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREK 1456
Cdd:TIGR02168  768 ERLEEAEE-ELAEAEAEIEELEAQIEQLKEELK-ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEE 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1457 EVESLRTQLLDFQAQ-SDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARL--- 1532
Cdd:TIGR02168  846 QIEELSEDIESLAAEiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREkla 925

                          730       740
                   ....*....|....*....|.
gi 568967306  1533 EGRNRAKHLRQTIQSLRRQFS 1553
Cdd:TIGR02168  926 QLELRLEGLEVRIDNLQERLS 946
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 28-557 3.79e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 3.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    28 LLISLSKVEVNELK------NEDQENMIHLFRITQSLMKMK----AQEVELALEEVEKAGEEQAKFeNQLKTKVMKLENE 97
Cdd:TIGR02168  225 LELALLVLRLEELReeleelQEELKEAEEELEELTAELQELeeklEELRLEVSELEEEIEELQKEL-YALANEISRLEQQ 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    98 LEMAQQSAGGRDTRFLR--DEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIID 175
Cdd:TIGR02168  304 KQILRERLANLERQLEEleAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   176 YQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMR-----KNLEESVQEMEKMTDEY 250
Cdd:TIGR02168  384 LRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEleeleEELEELQEELERLEEAL 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   251 NRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKV----------------EEWKL------ 308
Cdd:TIGR02168  464 EELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSglsgilgvlselisvdEGYEAaieaal 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   309 ------ILSSKDDEIIEYQQML-QSLRGK-----LKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEME---K 373
Cdd:TIGR02168  544 ggrlqaVVVENLNAAKKAIAFLkQNELGRvtflpLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllG 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   374 NTFIIEDLKNEL----QKDKGTSNFYQQTHYM-----------KIHSKVQILEEKTKEAERIAELAEADAREKDKELVEA 438
Cdd:TIGR02168  624 GVLVVDDLDNALelakKLRPGYRIVTLDGDLVrpggvitggsaKTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   439 LKRLKDYESGVYGL----EDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEF 514
Cdd:TIGR02168  704 RKELEELEEELEQLrkelEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 568967306   515 RNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQER 557
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 113-575 4.17e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRG 192
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  193 EDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENE 272
Cdd:COG1196   324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  273 HYRLQVRELTDLLKAKDEEddpvmmavnakVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDAdKSNIMALKQGIQE 352
Cdd:COG1196   404 ELEEAEEALLERLERLEEE-----------LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE-EALLELLAELLEE 471

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  353 RDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADA---- 428
Cdd:COG1196   472 AALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  429 -REKDKELVEALKRLKDYESG-------------------------VYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINK 482
Cdd:COG1196   552 vVEDDEVAAAAIEYLKAAKAGratflpldkiraraalaaalargaiGAAVDLVASDLREADARYYVLGDTLLGRTLVAAR 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  483 LEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNA 562
Cdd:COG1196   632 LEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                         490
                  ....*....|...
gi 568967306  563 ASGLTIDDLNLSE 575
Cdd:COG1196   712 AEEERLEEELEEE 724
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 109-447 7.54e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.54  E-value: 7.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   109 DTRFLRDEIRQLEKQLEQKDRELEDMEKELDK-EKKVNEQLALRNE------EAENENSKLRRENEQLRQDIIDYQKQID 181
Cdd:TIGR02169  668 FSRSEPAELQRLRERLEGLKRELSSLQSELRRiENRLDELSQELSDasrkigEIEKEIEQLEQEEEKLKERLEELEEDLS 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   182 SQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTL--TEANEKIEVQNQEMRKnLEESVQEMEKMTDEYNRMKALVHQ 259
Cdd:TIGR02169  748 SLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLeaRLSHSRIPEIQAELSK-LEEEVSRIEARLREIEQKLNRLTL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   260 SDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDdpvmmavNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKN--AQLD 337
Cdd:TIGR02169  827 EKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL-------NGKKEELEEELEELEAALRDLESRLGDLKKERDEleAQLR 899

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   338 ADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKntfiIEDLKNELQKDKGTSNFYQqthymKIHSKVQILEEKTKEA 417
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE----IEDPKGEDEEIPEEELSLE-----DVQAELQRVEEEIRAL 970

                          330       340       350
                   ....*....|....*....|....*....|
gi 568967306   418 ERIAELAEadarekdKELVEALKRLKDYES 447
Cdd:TIGR02169  971 EPVNMLAI-------QEYEEVLKRLDELKE 993
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1757-2619 7.62e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.53  E-value: 7.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1757 EKLKEKESALRLAEQNILSRDKVINELRLRLPaTADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLKK 1836
Cdd:TIGR02168  172 ERRKETERKLERTRENLDRLEDILNELERQLK-SLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1837 YQHLLEKAREEQREIVKKHEEdLHVLHHKLEQQAdnslnkfrQTAQDLLKQspapvptnkHFIRLAEMEQTVAEQDDSLS 1916
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEE-LRLEVSELEEEI--------EELQKELYA---------LANEISRLEQQKQILRERLA 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1917 SLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQEthasevkkVKAEVEDLRHALAQAHKDSQSLKSELQAQKEAnsra 1996
Cdd:TIGR02168  313 NLERQLEELEAQLEELESKLDELAEELAELEEKLEE--------LKEELESLEAELEELEAELEELESRLEELEEQ---- 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1997 ptttmrnlVDRLKSQLALKEKQQKALSRALLELRSEMTAAAE--ERIIAVTSQKEANLNVQQVVERHTR---------EL 2065
Cdd:TIGR02168  381 --------LETLRSKVAQLELQIASLNNEIERLEARLERLEDrrERLQQEIEELLKKLEEAELKELQAEleeleeeleEL 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2066 KSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNE---LQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQ-- 2140
Cdd:TIGR02168  453 QEELERLEEALEELREELEEAEQALDAAERELAQLQARldsLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvd 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2141 -------SKTLIDNKQSLIDELQKKVKK-LESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEG 2212
Cdd:TIGR02168  533 egyeaaiEAALGGRLQAVVVENLNAAKKaIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDP 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2213 EAHG--------------LAKQLNTLKEL-----------------------FAKADKEKLTLQKKLKTTGMTVDQvLGV 2255
Cdd:TIGR02168  613 KLRKalsyllggvlvvddLDNALELAKKLrpgyrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIEE-LEE 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2256 RALESEKELEELKKKNLDLENDilymrtqqalprdsvVEDLHLQNKYLQEKLHTLEKKLSK-EKYSQSLTSEIESDDHCQ 2334
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEE---------------LEQLRKELEELSRQISALRKDLARlEAEVEQLEERIAQLSKEL 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2335 KEQELQKEnlKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRG-AGRSGKTIPELEKTIG 2413
Cdd:TIGR02168  757 TELEAEIE--ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEeAANLRERLESLERRIA 834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2414 LMKKVVEKVQRENEQLKKASGILTSEkMATIEEENRNLKAELEKLKAHFgRQLSMQFESKNKGTEKIVAENERLRKELKK 2493
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAE-IEELEELIEELESELEALLNER-ASLEEALALLRSELEELSEELRELESKRSE 912

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2494 EIEASEKLRIAKNNLELVNDKMAAQLEETGKRLqfAESRAPQLEGADSKswksivvSRVYETKMKELESDIAKKNQSITD 2573
Cdd:TIGR02168  913 LRRELEELREKLAQLELRLEGLEVRIDNLQERL--SEEYSLTLEEAEAL-------ENKIEDDEEEARRRLKRLENKIKE 983

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*.
gi 568967306  2574 LKQLVREATEREQKAKKYTEDLEQQIEILKnvpEGAETEQELIREL 2619
Cdd:TIGR02168  984 LGPVNLAAIEEYEELKERYDFLTAQKEDLT---EAKETLEEAIEEI 1026
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1919-2679 1.01e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1919 LTKLKKVSKDLEKQKEitelkvrefentKLRLQETHASEVKKVKAEVEDLRHALAQAHKdsQSLKSELQAQKEAnsrapt 1998
Cdd:TIGR02168  188 LDRLEDILNELERQLK------------SLERQAEKAERYKELKAELRELELALLVLRL--EELREELEELQEE------ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1999 ttmrnlVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANlNVQQVVERHTRELKSQIEDLNENLLK 2078
Cdd:TIGR02168  248 ------LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALA-NEISRLEQQKQILRERLANLERQLEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2079 LKEALKTSKNKENSLADDLNELNNELQKKQKaynkilrEKDGIDQENDELRRQIKRLSSGLQSK-TLIDNKQSLIDELQK 2157
Cdd:TIGR02168  321 LEAQLEELESKLDELAEELAELEEKLEELKE-------ELESLEAELEELEAELEELESRLEELeEQLETLRSKVAQLEL 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2158 KVKKLESQLERKVDDV-DIKPVKEKSSKEelIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKL 2236
Cdd:TIGR02168  394 QIASLNNEIERLEARLeRLEDRRERLQQE--IEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2237 TLQKKLKTTGMTVDQvLGVRALESEKELEELKKKNLDLENdILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLsk 2316
Cdd:TIGR02168  472 EAEQALDAAERELAQ-LQARLDSLERLQENLEGFSEGVKA-LLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRL-- 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2317 ekysQSLTseIESDDHCQKEQELQKENLKLSSENIELkfqleqankdlprlknqvkDLKEMCEFLKKGKLELERKLGQVR 2396
Cdd:TIGR02168  548 ----QAVV--VENLNAAKKAIAFLKQNELGRVTFLPL-------------------DSIKGTEIQGNDREILKNIEGFLG 602

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2397 GAGRSGKTIPELEKTIGLM---KKVVEKVQRENEQLKKasgiltsekmatIEEENRNLKAELEKLKAHFgrQLSMQFESK 2473
Cdd:TIGR02168  603 VAKDLVKFDPKLRKALSYLlggVLVVDDLDNALELAKK------------LRPGYRIVTLDGDLVRPGG--VITGGSAKT 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2474 NKGTEKIVAENERLRKELKkeiEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVY 2553
Cdd:TIGR02168  669 NSSILERRREIEELEEKIE---ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2554 ETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETE--------QELIRELQLLRLA 2625
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAldelraelTLLNEEAANLRER 825

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568967306  2626 NNQMDKERAELIHQIEINKDQTRADSSipDSDQLKEKINDLETQLRKLELEKQH 2679
Cdd:TIGR02168  826 LESLERRIAATERRLEDLEEQIEELSE--DIESLAAEIEELEELIEELESELEA 877
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1245-2135 1.05e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1245 KQYNELTTKYRDiLQKDNMLVQRTSNLEHLEcenaSLKEQMEAISKELEITKEKLHTIEQAWEqETKLGnDSNMDKAKKS 1324
Cdd:TIGR02168  213 ERYKELKAELRE-LELALLVLRLEELREELE----ELQEELKEAEEELEELTAELQELEEKLE-ELRLE-VSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1325 MTnSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELadsv 1404
Cdd:TIGR02168  286 LQ-KELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL---- 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1405 tkavsDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESL---RTQLLDFQAQSDEKALIAKL 1481
Cdd:TIGR02168  361 -----EELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLedrRERLQQEIEELLKKLEEAEL 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1482 HQHVVSLQISEATalgkLESVTSKLQKMEAYNLRLEQKLDEKEQALYYArlegRNRAKHLRQTIQSLRRQFSgalplaQQ 1561
Cdd:TIGR02168  436 KELQAELEELEEE----LEELQEELERLEEALEELREELEEAEQALDAA----ERELAQLQARLDSLERLQE------NL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1562 EKFSKTMIQLQNDKLKImqemknsqqehrnmenktlelelklkglEELISTLKDARGAQKviNWHVKIEEL---RLQELk 1638
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGL----------------------------SGILGVLSELISVDE--GYEAAIEAAlggRLQAV- 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1639 lnreLVKGKEEIKylnniiseyeHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQ---NEILSAAQKFED 1715
Cdd:TIGR02168  551 ----VVENLNAAK----------KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLgvaKDLVKFDPKLRK 616

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1716 STGSMPDPSLPLPNqLEIALRKIKEniqviLKTQATCKSLEEKLKEKESAL----RLAEQNILSRDKVINELRLRLPATA 1791
Cdd:TIGR02168  617 ALSYLLGGVLVVDD-LDNALELAKK-----LRPGYRIVTLDGDLVRPGGVItggsAKTNSSILERRREIEELEEKIEELE 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1792 DREKlIAELERKELEpkshhtmkIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQAD 1871
Cdd:TIGR02168  691 EKIA-ELEKALAELR--------KELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1872 --NSLNKFRQTAQDLLKQSPApvptnkhfiRLAEMEQTVAEQDDSLSSLLTKLKkvskdlEKQKEITELKvREFENTKLR 1949
Cdd:TIGR02168  762 eiEELEERLEEAEEELAEAEA---------EIEELEAQIEQLKEELKALREALD------ELRAELTLLN-EEAANLRER 825

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1950 LQEtHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEAnsraptttmrnlVDRLKSQLALKEKQQKALSRALLEL 2029
Cdd:TIGR02168  826 LES-LERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEEL------------IEELESELEALLNERASLEEALALL 892

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2030 RSEMTAAAEEriiavtsqkeanlnvQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNEL-NNELQKKQ 2108
Cdd:TIGR02168  893 RSELEELSEE---------------LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAE 957

                          890       900
                   ....*....|....*....|....*..
gi 568967306  2109 KAYNKILREKDGIDQENDELRRQIKRL 2135
Cdd:TIGR02168  958 ALENKIEDDEEEARRRLKRLENKIKEL 984
PTZ00121 PTZ00121
MAEBL; Provisional
 2016-2729 1.13e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2016 EKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQvvERHTRELKSQIEDLNENLLKLKEALKTS-----KNKE 2090
Cdd:PTZ00121 1236 KKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEE--ARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEE 1313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2091 NSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSliDELQKKVKKLESQLE--R 2168
Cdd:PTZ00121 1314 AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKK--EEAKKKADAAKKKAEekK 1391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2169 KVDDVDIKPVKEKSSKEELIRWEEGKKwqtkveglrnrlkeKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMT 2248
Cdd:PTZ00121 1392 KADEAKKKAEEDKKKADELKKAAAAKK--------------KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK 1457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2249 VDQVLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKE---KYSQSLTS 2325
Cdd:PTZ00121 1458 KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEakkAEEAKKAD 1537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2326 EIESDDHCQKEQELQK-ENLKLSSE--NIELKFQLEQANKDLPRLKNQVKDLKE--MCEFLKKGKLELERKLGQVRGAGR 2400
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKaEELKKAEEkkKAEEAKKAEEDKNMALRKAEEAKKAEEarIEEVMKLYEEEKKMKAEEAKKAEE 1617

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2401 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAhfgRQLSMQFESKNKGTEKI 2480
Cdd:PTZ00121 1618 AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKA---EEAKKAEEDEKKAAEAL 1694

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2481 VAENERLRK-ELKKEIEASEKlriaknnlelvndKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKE 2559
Cdd:PTZ00121 1695 KKEAEEAKKaEELKKKEAEEK-------------KKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAH 1761

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2560 LESDIAKKNQSITDLKQLV------REATEREQKAKKYTEDLEQQIEIL-----KNVPEGAETEQELIRELQLLRLANNq 2628
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVieeeldEEDEKRRMEVDKKIKDIFDNFANIieggkEGNLVINDSKEMEDSAIKEVADSKN- 1840

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2629 MDKERAELIHQIEINKDQTRADSSIPDSDQLKEKIN--DLETQLRKLELEKQHSkEEVKKLKKELENFDPSFFEEIEDlK 2706
Cdd:PTZ00121 1841 MQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLkeDDEEEIEEADEIEKID-KDDIEREIPNNNMAGKNNDIIDD-K 1918

                         730       740
                  ....*....|....*....|....
gi 568967306 2707 YNYKEEVKKNI-LLEEKLKKLSEQ 2729
Cdd:PTZ00121 1919 LDKDEYIKRDAeETREEIIKISKK 1942
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1901-2677 2.06e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 2.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1901 LAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITEL--KVREFENTKL--RLQETHAS-------------EVKKVKA 1963
Cdd:TIGR02169  179 LEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALlkEKREYEGYELlkEKEALERQkeaierqlasleeELEKLTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1964 EVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNL---VDRLKSQLALKEKQQKALSRALLELRSEMTAAAEER 2040
Cdd:TIGR02169  259 EISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELeaeIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEI 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2041 IIAVTSQKEANLNVQQVVERHtRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDG 2120
Cdd:TIGR02169  339 EELEREIEEERKRRDKLTEEY-AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQR 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2121 IDQENDELRRQIKRLSSGLqsKTLIDNKQSLIDE----------LQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRW 2190
Cdd:TIGR02169  418 LSEELADLNAAIAGIEAKI--NELEEEKEDKALEikkqewkleqLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEA 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2191 E-EGKKWQTKVEGLRNR---LKEKEGEAHGLAKQLNTLKELFAKA-------------------DKEKLTLQKKLKTTGM 2247
Cdd:TIGR02169  496 EaQARASEERVRGGRAVeevLKASIQGVHGTVAQLGSVGERYATAievaagnrlnnvvveddavAKEAIELLKRRKAGRA 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2248 TVDQVLGVRALESEKELEELKKKNLDLENDILYMRT-----QQALPRDSVVEDLHLQNKYL-QEKLHTLEKKLSKEkySQ 2321
Cdd:TIGR02169  576 TFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKyepafKYVFGDTLVVEDIEAARRLMgKYRMVTLEGELFEK--SG 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2322 SLTSEIESDDHCQKEQELQKENLKLSSENIE-LKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRG-AG 2399
Cdd:TIGR02169  654 AMTGGSRAPRGGILFSRSEPAELQRLRERLEgLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQeEE 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2400 RSGKTIPELEKTIGLMKKVVEKVQRENEQLKKasgiltseKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEK 2479
Cdd:TIGR02169  734 KLKERLEELEEDLSSLEQEIENVKSELKELEA--------RIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEE 805

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2480 IVAENERLRKELKKEIEAS----EKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEgadskswksivvsrvyeT 2555
Cdd:TIGR02169  806 EVSRIEARLREIEQKLNRLtlekEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE-----------------E 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2556 KMKELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILK-NVPEGAETEQELIRELQLLRLANNQMDKERA 2634
Cdd:TIGR02169  869 ELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRkRLSELKAKLEALEEELSEIEDPKGEDEEIPE 948

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568967306  2635 EL--IHQIEINKDQTRADSS---------IPDSDQLKEKINDLETQLRKLELEK 2677
Cdd:TIGR02169  949 EElsLEDVQAELQRVEEEIRalepvnmlaIQEYEEVLKRLDELKEKRAKLEEER 1002
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 75-459 2.11e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.99  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    75 KAGEEQAKFENQLKTKVMKLENELEMAQQsaggrDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEE 154
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEE-----ELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   155 AENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRK 234
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATER 838

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   235 NLEESVQEMEKMTDEynrmkalvhqsdavMDQIKKENEHYRLQVRELTDLLKAKDEEddpvMMAVNAKVEEWKLILSSKD 314
Cdd:TIGR02168  839 RLEDLEEQIEELSED--------------IESLAAEIEELEELIEELESELEALLNE----RASLEEALALLRSELEELS 900

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   315 DEIIEYQQMLQSLRGKLKNAQLDADKSNiMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKdkgtsnf 394
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLAQLE-LRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR------- 972

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967306   395 yqqthymkihsKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEI 459
Cdd:TIGR02168  973 -----------RLKRLENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1066-1974 3.31e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 3.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1066 LQELDNKEKKLKHLEDSLEDYNRKFAVIRHQ--QSLLYKEYLSE-----KDIWKTDSEMIREEKRKLEDQAEQDAVKVKE 1138
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELERQLKSLERQaeKAERYKELKAElreleLALLVLRLEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1139 YNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKEngkhRNDVIAMEAEVTEKLGSLQRFKE 1218
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER----LANLERQLEELEAQLEELESKLD 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1219 MAIFKIAALQKVIDnsVSLSELELANKQYNELTTKYRDILQKdnmLVQRTSNLEHLECENASLKEQMEAISKELEITKEK 1298
Cdd:TIGR02168  334 ELAEELAELEEKLE--ELKEELESLEAELEELEAELEELESR---LEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1299 LHTIEQAWE--QETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1376
Cdd:TIGR02168  409 LERLEDRRErlQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1377 TKFTELTKINLDAQKVEQMLRDELADsvtKAVSDADRQRILELEKSEVELKVEVSK---------LREISDIAKRQVDFL 1447
Cdd:TIGR02168  489 ARLDSLERLQENLEGFSEGVKALLKN---QSGLSGILGVLSELISVDEGYEAAIEAalggrlqavVVENLNAAKKAIAFL 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1448 nsqqqsreKEVESLRTQLLDFQAQSDekALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQAL 1527
Cdd:TIGR02168  566 --------KQNELGRVTFLPLDSIKG--TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNAL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1528 YYARLEGRnrakhlRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDklkimQEMKNSQQEHRNMENKTLELELKLKGLE 1607
Cdd:TIGR02168  636 ELAKKLRP------GYRIVTLDGDLVRPGGVITGGSAKTNSSILERR-----REIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1608 ELISTLKDArgaqkvinwhvkIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQ 1687
Cdd:TIGR02168  705 KELEELEEE------------LEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1688 REVELERQLDIFDHQQNEIlsaaqkfedstgsmpdpslplpNQLEIALRKIKENIQvilKTQATCKSLEEKLKEKESALR 1767
Cdd:TIGR02168  773 AEEELAEAEAEIEELEAQI----------------------EQLKEELKALREALD---ELRAELTLLNEEAANLRERLE 827

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1768 LAEQNILSRDKVINELRLRLP-ATADREKLIAELERKELEPKSHhtmkiaHQTIANMQARLNHKEEVLKKYQHLLEKARE 1846
Cdd:TIGR02168  828 SLERRIAATERRLEDLEEQIEeLSEDIESLAAEIEELEELIEEL------ESELEALLNERASLEEALALLRSELEELSE 901

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1847 EQREI---VKKHEEDLHVLHHKLEqQADNSLNKFRQTAQDLLKQSpapvpTNKHFIRLAEMEQTVAEQDDSLSSLLTKLK 1923
Cdd:TIGR02168  902 ELRELeskRSELRRELEELREKLA-QLELRLEGLEVRIDNLQERL-----SEEYSLTLEEAEALENKIEDDEEEARRRLK 975

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568967306  1924 KVSKDLEKQKEITELKVREFENTKLRLQEthasevkkVKAEVEDLRHALAQ 1974
Cdd:TIGR02168  976 RLENKIKELGPVNLAAIEEYEELKERYDF--------LTAQKEDLTEAKET 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1628-2168 6.60e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 6.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1628 KIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEIL 1707
Cdd:COG1196   268 ELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1708 SAAQKFEDSTGSMpdpslplpNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRL 1787
Cdd:COG1196   348 EAEEELEEAEAEL--------AEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1788 PATADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLKKYQhlLEKAREEQREIVKKHEEDLHVLHHKLE 1867
Cdd:COG1196   420 EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE--EAALLEAALAELLEELAEAAARLLLLL 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1868 QQADNSLNKFRQTAQDLLKQSPAPVPtnKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKvrefENTK 1947
Cdd:COG1196   498 EAEADYEGFLEGVKAALLLAGLRGLA--GAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK----AAKA 571

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1948 LRLQETHASEVKKVKAEVEDlrHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKqqKALSRALL 2027
Cdd:COG1196   572 GRATFLPLDKIRARAALAAA--LARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRA--VTLAGRLR 647

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2028 ELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKK 2107
Cdd:COG1196   648 EVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALE 727

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568967306 2108 QKAYNKILREKDGIDQENDELRRQIKRLSSGLQSktlidnkqslIDELQKKVKKLESQLER 2168
Cdd:COG1196   728 EQLEAEREELLEELLEEEELLEEEALEELPEPPD----------LEELERELERLEREIEA 778
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
54-187 1.19e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 54.09  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   54 ITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMaqqsaggrdtrfLRDEIRQLEKQLEQKDRELED 133
Cdd:COG2433   378 IEEALEELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVER------------LEAEVEELEAELEEKDERIER 445

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568967306  134 MEKELDKEKKVNEQLALRNEEAenenSKLRRENEQLRQDIIDYQKQIDSQKESL 187
Cdd:COG2433   446 LERELSEARSEERREIRKDREI----SRLDREIERLERELEEERERIEELKRKL 495
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 79-379 1.30e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.30  E-value: 1.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    79 EQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENE 158
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEA 780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   159 NSKLRRENEQLRQDIIdyQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEE 238
Cdd:TIGR02169  781 LNDLEARLSHSRIPEI--QAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIEN 858

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   239 SVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELT---DLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDD 315
Cdd:TIGR02169  859 LNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELErkiEELEAQIEKKRKRLSELKAKLEALEEELSEIED 938

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568967306   316 ---EIIEYQQMLQSLrGKLKnAQLDADKSNIMALK----QGIQERDSQIKMLTEQVEQYTKEMEKNTFIIE 379
Cdd:TIGR02169  939 pkgEDEEIPEEELSL-EDVQ-AELQRVEEEIRALEpvnmLAIQEYEEVLKRLDELKEKRAKLEEERKAILE 1007
PRK11281 PRK11281
mechanosensitive channel MscK;
1913-2165 1.83e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 53.76  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1913 DSLSSLLTKLKKvSKDLEKQKEITelkVREFENTKLRLQEThasevKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEA 1992
Cdd:PRK11281   39 ADVQAQLDALNK-QKLLEAEDKLV---QQDLEQTLALLDKI-----DRQKEETEQLKQQLAQAPAKLRQAQAELEALKDD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1993 NSRAPTTTMRNL-VDRLKSQLALKEKQQKALSRALLELRSEMTAA--AEERiiavtSQKEANLNVQQvverhTRELKSQI 2069
Cdd:PRK11281  110 NDEETRETLSTLsLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLqtQPER-----AQAALYANSQR-----LQQIRNLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2070 EDLNENLLKLKEALKTSKNKENSLADdlneLNNELQKKQKAYNKILreKDGIDQENDELRRQIKRLSSGLQS-KTLIDNK 2148
Cdd:PRK11281  180 KGGKVGGKALRPSQRVLLQAEQALLN----AQNDLQRKSLEGNTQL--QDLLQKQRDYLTARIQRLEHQLQLlQEAINSK 253

                         250
                  ....*....|....*..
gi 568967306 2149 QslIDELQKKVKKLESQ 2165
Cdd:PRK11281  254 R--LTLSEKTVQEAQSQ 268
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 21-557 2.14e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   21 QEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFEnQLKTKVMKLENELEM 100
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELE-EAQAEEYELLAELAR 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  101 AQQsaggrDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQI 180
Cdd:COG1196   300 LEQ-----DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  181 DSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQS 260
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  261 DAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDpvmmavNAKVEEWKLILSSKDDEiiEYQQMLQSLRGKLKNAQLDADK 340
Cdd:COG1196   455 EEEEEALLELLAELLEEAALLEAALAELLEELA------EAAARLLLLLEAEADYE--GFLEGVKAALLLAGLRGLAGAV 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  341 SnIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKnelQKDKGTSNFYQQThymkihskvQILEEKTKEAERI 420
Cdd:COG1196   527 A-VLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK---AAKAGRATFLPLD---------KIRARAALAAALA 593

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  421 AELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRER 500
Cdd:COG1196   594 RGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAA 673

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568967306  501 AGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQER 557
Cdd:COG1196   674 LLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1826-2674 2.47e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 2.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1826 RLNHKEEVLKKYQHLLEKARE-EQREIVKKHEEdlhvlHHKLEQQADNSLNKFRQTAQDLLKQSPApvpTNKHFIRLAEM 1904
Cdd:TIGR02169  202 RLRREREKAERYQALLKEKREyEGYELLKEKEA-----LERQKEAIERQLASLEEELEKLTEEISE---LEKRLEEIEQL 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1905 EQTVAEQDDSLSS-----LLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHaSEVKKVKAEVEDLRHALAQAHKDS 1979
Cdd:TIGR02169  274 LEELNKKIKDLGEeeqlrVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLE-AEIDKLLAEIEELEREIEEERKRR 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1980 QSLKSELQAQKEAnsraptttmrnlVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERiiavtsqkeanlnvqqvve 2059
Cdd:TIGR02169  353 DKLTEEYAELKEE------------LEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI------------------- 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2060 rhtRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLssgl 2139
Cdd:TIGR02169  402 ---NELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDL---- 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2140 qsktlidnkQSLIDELQKKVKKLESQLERKvddvdikpvkeKSSKEELIRWEEGKKWQTKVeglrnrLKEKEGEAHGLAK 2219
Cdd:TIGR02169  475 ---------KEEYDRVEKELSKLQRELAEA-----------EAQARASEERVRGGRAVEEV------LKASIQGVHGTVA 528

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2220 QLNTLKELFAKA-------------------DKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKKKNLDLENDILY 2280
Cdd:TIGR02169  529 QLGSVGERYATAievaagnrlnnvvveddavAKEAIELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEF 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2281 MRT-----QQALPRDSVVEDLHLQNKYL-QEKLHTLEKKLSKEkySQSLTSEIESDDHCQKEQELQKENLKLSSENIE-L 2353
Cdd:TIGR02169  609 DPKyepafKYVFGDTLVVEDIEAARRLMgKYRMVTLEGELFEK--SGAMTGGSRAPRGGILFSRSEPAELQRLRERLEgL 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2354 KFQLEQANKDLPRLKNQVKDLKEMCEflkkgklELERKLGqvrgagrsgktipELEKTIGLMKKVVEKVQRENEQLKkas 2433
Cdd:TIGR02169  687 KRELSSLQSELRRIENRLDELSQELS-------DASRKIG-------------EIEKEIEQLEQEEEKLKERLEELE--- 743

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2434 giltsEKMATIEEENRNLKAELEKLKAhfgrQLSMQFESKNKGTEKIVAENERLRKELKKEIEAS-EKLRIAKNNLELVN 2512
Cdd:TIGR02169  744 -----EDLSSLEQEIENVKSELKELEA----RIEELEEDLHKLEEALNDLEARLSHSRIPEIQAElSKLEEEVSRIEARL 814

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2513 DKMAAQLEETGKRLQFAESRAPQLEgADSKSWKSIVVSRvyETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYT 2592
Cdd:TIGR02169  815 REIEQKLNRLTLEKEYLEKEIQELQ-EQRIDLKEQIKSI--EKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKER 891

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2593 EDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERaelIHQIEINKDQTRADSS-IPDSDQLKEKINDLETQLR 2671
Cdd:TIGR02169  892 DELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEE---LSEIEDPKGEDEEIPEeELSLEDVQAELQRVEEEIR 968


                   ...
gi 568967306  2672 KLE 2674
Cdd:TIGR02169  969 ALE 971
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2008-2674 2.51e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2008 LKSQLALKEKQQKALSRALlELRSEmtaaAEERiiavtsQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSK 2087
Cdd:COG1196   198 LERQLEPLERQAEKAERYR-ELKEE----LKEL------EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2088 NKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLssglqsktlidnkQSLIDELQKKVKKLESQLE 2167
Cdd:COG1196   267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------------EERLEELEEELAELEEELE 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2168 RKvddvdikpvkekssKEELIRWEEgkkwqtkveglrnRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKklkttgm 2247
Cdd:COG1196   334 EL--------------EEELEELEE-------------ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE------- 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2248 tvdqvlgvRALESEKELEELKKKNLDLENDILYMRTQQAlprdsvvEDLHLQNKYLQEKLhtlekklskEKYSQSLTSEI 2327
Cdd:COG1196   380 --------ELEELAEELLEALRAAAELAAQLEELEEAEE-------ALLERLERLEEELE---------ELEEALAELEE 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2328 ESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPE 2407
Cdd:COG1196   436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2408 LEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSmqFESKNK-GTEKIVAENER 2486
Cdd:COG1196   516 LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRAT--FLPLDKiRARAALAAALA 593

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2487 LRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSrvyETKMKELESDIAK 2566
Cdd:COG1196   594 RGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGS---AGGSLTGGSRREL 670

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2567 KNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKnvpEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQ 2646
Cdd:COG1196   671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEER---ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEEL 747

                         650       660       670
                  ....*....|....*....|....*....|...
gi 568967306 2647 TRAD-----SSIPDSDQLKEKINDLETQLRKLE 2674
Cdd:COG1196   748 LEEEaleelPEPPDLEELERELERLEREIEALG 780
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1913-2389 3.95e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.76  E-value: 3.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1913 DSLSSLLTKLKKVSKDLEKQKEITELKVREFENtKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEA 1992
Cdd:PRK03918  234 EELKEEIEELEKELESLEGSKRKLEEKIRELEE-RIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREI 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1993 NSRAPT-TTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMtAAAEERIIAVTSQKEANLNVQQVVERHTRElksQIED 2071
Cdd:PRK03918  313 EKRLSRlEEEINGIEERIKELEEKEERLEELKKKLKELEKRL-EELEERHELYEEAKAKKEELERLKKRLTGL---TPEK 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2072 LNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKIL----------REKDGIDQEN--DELRRQIKRLSSGL 2139
Cdd:PRK03918  389 LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKEllEEYTAELKRIEKEL 468

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2140 qsKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAK 2219
Cdd:PRK03918  469 --KEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKK 546

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2220 QLNTLKELfakaDKEKLTLQKKLKTTGMTVDQVLGVRALESEKELEELKKKNLDLENdiLYMRTQQALPRDSVVEDLHLQ 2299
Cdd:PRK03918  547 ELEKLEEL----KKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEP--FYNEYLELKDAEKELEREEKE 620

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2300 NKYLQEKLHTLEKKLSK-EKYSQSLTSEIESDDHCQKEQE---LQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLK 2375
Cdd:PRK03918  621 LKKLEEELDKAFEELAEtEKRLEELRKELEELEKKYSEEEyeeLREEYLELSRELAGLRAELEELEKRREEIKKTLEKLK 700

                         490
                  ....*....|....
gi 568967306 2376 EMCEFLKKGKLELE 2389
Cdd:PRK03918  701 EELEEREKAKKELE 714
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
87-563 4.01e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.76  E-value: 4.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   87 LKTKVMKLENELEMAQQSAGGrdtrfLRDEIRQLEKQLEQKDRELEDME------KELDKEKKVNEQLALRNEEAENENS 160
Cdd:PRK03918  236 LKEEIEELEKELESLEGSKRK-----LEEKIRELEERIEELKKEIEELEekvkelKELKEKAEEYIKLSEFYEEYLDELR 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  161 KLRRENEQLRQDIIDYQKQIdSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLT---------------EANEKI 225
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERI-KELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKakkeelerlkkrltgLTPEKL 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  226 EVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTdllkakdEEDDPVMMavnakvEE 305
Cdd:PRK03918  390 EKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT-------EEHRKELL------EE 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  306 WKLILSSKDDEIIEYQQMLQSLRGKLKNAQ-LDADKSNIMALKQGIQerdsQIKMLTEQVEQYTKE-MEKNTFIIEDLKN 383
Cdd:PRK03918  457 YTAELKRIEKELKEIEEKERKLRKELRELEkVLKKESELIKLKELAE----QLKELEEKLKKYNLEeLEKKAEEYEKLKE 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  384 ELQKDKGtsnfyQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVE-ALKRLKDYESGVYGLEDA---VIEI 459
Cdd:PRK03918  533 KLIKLKG-----EIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEElGFESVEELEERLKELEPFyneYLEL 607

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  460 KNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGlEPKTMIDLTEFRNsKRLKQQQYRAENQVLLKEIESL 539
Cdd:PRK03918  608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE-ELEKKYSEEEYEE-LREEYLELSRELAGLRAELEEL 685

                         490       500
                  ....*....|....*....|....
gi 568967306  540 EEERLDLKRKIRQMAQERGKRNAA 563
Cdd:PRK03918  686 EKRREEIKKTLEKLKEELEEREKA 709
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1628-2235 4.05e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.76  E-value: 4.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1628 KIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERqmawdQREVELERQLDIFDHQQNEIL 1707
Cdd:PRK03918  239 EIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKA-----EEYIKLSEFYEEYLDELREIE 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1708 SAAQKFEDstgsmpdpslpLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQnILSRDKVINELRLRL 1787
Cdd:PRK03918  314 KRLSRLEE-----------EINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEE-AKAKKEELERLKKRL 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1788 pATADREKLIAELERKElepKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREE----QREIVKKHEEDLhvlh 1863
Cdd:PRK03918  382 -TGLTPEKLEKELEELE---KAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcGRELTEEHRKEL---- 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1864 hkleqqadnslnkfrqtaqdllkqspapvpTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELK--VR 1941
Cdd:PRK03918  454 ------------------------------LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKelAE 503

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1942 EFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTttmrnlvdrLKSQLALKEKQQKA 2021
Cdd:PRK03918  504 QLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE---------LEKKLDELEEELAE 574

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2022 LSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVverhtrelKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELN 2101
Cdd:PRK03918  575 LLKELEELGFESVEELEERLKELEPFYNEYLELKDA--------EKELEREEKELKKLEEELDKAFEELAETEKRLEELR 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2102 NELQKKQKAYNKilREKDGIDQENDELRRQIKRLSSGLQSktlidnKQSLIDELQKKVKKLESQLErkvddvdikpvKEK 2181
Cdd:PRK03918  647 KELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEE------LEKRREEIKKTLEKLKEELE-----------ERE 707

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306 2182 SSKEELirwEEGKKWQTKVEGLRNRLKEKEGEA--HGLAKQLNTLKELFAKADKEK 2235
Cdd:PRK03918  708 KAKKEL---EKLEKALERVEELREKVKKYKALLkeRALSKVGEIASEIFEELTEGK 760
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1836-2240 5.03e-06

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 52.07  E-value: 5.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1836 KYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADnslnKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVA------ 1909
Cdd:pfam09731   31 NFRDFFEEYIPYGEEVVLYALGEDPPLAPKPKTFRP----LQPSVVSAVTGESKEPKEEKKQVKIPRQSGVSSEvaeeek 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1910 -EQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQA 1988
Cdd:pfam09731  107 eATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQ 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1989 QKEANSRAPTTTM----RNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVerhtRE 2064
Cdd:pfam09731  187 KAEALAEKLKEVInlakQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQ----QE 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2065 LKSQIEDLNENLlklKEALKTSKNKENSLAD----DLNELNNELQKKQKAYNKilREKDGIDQENDELRRQIKRLSSGLQ 2140
Cdd:pfam09731  263 LVSIFPDIIPVL---KEDNLLSNDDLNSLIAhahrEIDQLSKKLAELKKREEK--HIERALEKQKEELDKLAEELSARLE 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2141 SKTLIDNKQsLIDELQKKVK--------KLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEG 2212
Cdd:pfam09731  338 EVRAADEAQ-LRLEFEREREeiresyeeKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEERAGRLLKLN 416

                          410       420
                   ....*....|....*....|....*...
gi 568967306  2213 EAHGLAKQLNTLKELFAKADKEKLTLQK 2240
Cdd:pfam09731  417 ELLANLKGLEKATSSHSEVEDENRKAQQ 444
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
113-556 5.17e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 52.35  E-value: 5.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRG 192
Cdd:PRK02224  277 LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEE 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  193 EDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDeynrmkalvhqsdavmdqikkene 272
Cdd:PRK02224  357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAED------------------------ 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  273 hyrlqvrELTDLLKAKDEeddpvmmaVNAKVEEWKLILSSKDDEIIEYQQMLQSlrGKLKNAQLDADKSNIMAlkqGIQE 352
Cdd:PRK02224  413 -------FLEELREERDE--------LREREAELEATLRTARERVEEAEALLEA--GKCPECGQPVEGSPHVE---TIEE 472

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  353 RDSQIKMLTEQVEQYTKEmekntfiIEDLKNELQKDKGTSnfyqqthymKIHSKVQILEEKTKEAERIAELAEADAREKD 432
Cdd:PRK02224  473 DRERVEELEAELEDLEEE-------VEEVEERLERAEDLV---------EAEDRIERLEERREDLEELIAERRETIEEKR 536

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  433 KELVEALKRLKDYESGVYGLEDAV----IEIKNCKAQIKIRDGEMEVLTKEINKLEmKINDILDENEALRERAGLEPKTM 508
Cdd:PRK02224  537 ERAEELRERAAELEAEAEEKREAAaeaeEEAEEAREEVAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIERLREKR 615

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 568967306  509 IDLTEFRNSKRLKQQQYRAENQVLLkeiESLEEERLDLKRKIRQMAQE 556
Cdd:PRK02224  616 EALAELNDERRERLAEKRERKRELE---AEFDEARIEEAREDKERAEE 660
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1646-2537 7.65e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 51.66  E-value: 7.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1646 GKEEIKylnNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGSmpdpsl 1725
Cdd:pfam15921   72 GKEHIE---RVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQED------ 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1726 pLPNQLEIALRKIKeniqvilktqaTCKSL-EEKLKEKESALRLAEQNILSRDKVINELRLRLP--ATADREKL-----I 1797
Cdd:pfam15921  143 -LRNQLQNTVHELE-----------AAKCLkEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVdfEEASGKKIyehdsM 210

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1798 AELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLK--------KYQHLLEKAREEQREIVKKHEEDLHVLHHKlEQQ 1869
Cdd:pfam15921  211 STMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEalksesqnKIELLLQQHQDRIEQLISEHEVEITGLTEK-ASS 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1870 ADNSLNKFRqtAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITelkvrefeNTKLR 1949
Cdd:pfam15921  290 ARSQANSIQ--SQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLA--------NSELT 359

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1950 LQETHASEVKKVKAEVED-LRHALAQAHKDSQslksELQAQKEANSRAPTTTMRN--LVDRLKSQLALKEKQQKALSRAL 2026
Cdd:pfam15921  360 EARTERDQFSQESGNLDDqLQKLLADLHKREK----ELSLEKEQNKRLWDRDTGNsiTIDHLRRELDDRNMEVQRLEALL 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2027 LELRSEMTAAAEERIIAVTSQKEANLNVQQvverhtreLKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQK 2106
Cdd:pfam15921  436 KAMKSECQGQMERQMAAIQGKNESLEKVSS--------LTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2107 KQKAynkilrekdgidqendelrrqikrlssglqsktlidnkqslIDELQKKVKKLESQLerkvdDVDIKPVKEKSSKEE 2186
Cdd:pfam15921  508 KERA-----------------------------------------IEATNAEITKLRSRV-----DLKLQELQHLKNEGD 541

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2187 LIRweegkKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADK-------EKLTLQKKLKTTGMTVdQVLGVRALE 2259
Cdd:pfam15921  542 HLR-----NVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRtagamqvEKAQLEKEINDRRLEL-QEFKILKDK 615

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2260 SEKELEELKKKNLDLENDILYMrTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSkekysqSLTseiesddhcqKEQEL 2339
Cdd:pfam15921  616 KDAKIRELEARVSDLELEKVKL-VNAGSERLRAVKDIKQERDQLLNEVKTSRNELN------SLS----------EDYEV 678

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2340 QKENLKLSSENIE-----LKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGagrsgkTIPELEKTIGL 2414
Cdd:pfam15921  679 LKRNFRNKSEEMEtttnkLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG------QIDALQSKIQF 752

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2415 MKKVVEKVQRENEQLKKASGILtSEKMATIEEENRNLKAELEKLKAhfgrqlsmqfesknkgtekivaENERLRKELKke 2494
Cdd:pfam15921  753 LEEAMTNANKEKHFLKEEKNKL-SQELSTVATEKNKMAGELEVLRS----------------------QERRLKEKVA-- 807

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|...
gi 568967306  2495 ieaseklriaknNLELVNDKMAAQLEETGKRLQFAESRAPQLE 2537
Cdd:pfam15921  808 ------------NMEVALDKASLQFAECQDIIQRQEQESVRLK 838
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1730-2240 7.76e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.60  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1730 QLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELE--- 1806
Cdd:PRK03918  218 ELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyik 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1807 -PKSHHTMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVL-----HHKLEQQADNSLNKFRQT 1880
Cdd:PRK03918  298 lSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLeeleeRHELYEEAKAKKEELERL 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1881 AQDLLKQSPAPVPTNKHFIRLAEME-----QTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREF-ENTKLRLQETH 1954
Cdd:PRK03918  378 KKRLTGLTPEKLEKELEELEKAKEEieeeiSKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELtEEHRKELLEEY 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1955 ASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEansrapTTTMRNLVDRLKSQlalkEKQQKALSRALLELRSEMT 2034
Cdd:PRK03918  458 TAELKRIEKELKEIEEKERKLRKELRELEKVLKKESE------LIKLKELAEQLKEL----EEKLKKYNLEELEKKAEEY 527

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2035 AAAEERIIAVTSQKEanlNVQQVVERhTRELKSQIEDLNENLLKLKEALKTSKNKENSLA-DDLNELNNELQKKQKAYNK 2113
Cdd:PRK03918  528 EKLKEKLIKLKGEIK---SLKKELEK-LEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNE 603

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2114 ILREKDGidqeNDELRRQIKRLSSglqSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEeg 2193
Cdd:PRK03918  604 YLELKDA----EKELEREEKELKK---LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRE-- 674

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 568967306 2194 kkwqtkVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQK 2240
Cdd:PRK03918  675 ------LAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEK 715
PTZ00121 PTZ00121
MAEBL; Provisional
 1420-2245 9.77e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 9.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1420 EKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSL-QISEATALGK 1498
Cdd:PTZ00121 1031 ELTEYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKaEEAKKTETGK 1110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1499 LESVTSKLQKM----EAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQND 1574
Cdd:PTZ00121 1111 AEEARKAEEAKkkaeDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKA 1190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1575 KLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKvinwhvKIEELRLQELKLNRELVKGKEEIKYLN 1654
Cdd:PTZ00121 1191 EELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKK------DAEEAKKAEEERNNEEIRKFEEARMAH 1264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1655 niISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDifdhqqneilSAAQKFEDStgsmpdpslplpNQLEIA 1734
Cdd:PTZ00121 1265 --FARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAD----------EAKKKAEEA------------KKADEA 1320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1735 LRKIKENIQvilKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMK 1814
Cdd:PTZ00121 1321 KKKAEEAKK---KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK 1397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1815 IAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQR--EIVKKHEEdlhvlhhkleqqadnslnkfRQTAQDLLKQSPAPv 1892
Cdd:PTZ00121 1398 KKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEE--------------------AKKADEAKKKAEEA- 1456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1893 ptnkhfiRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKV--KAEVEDLRH 1970
Cdd:PTZ00121 1457 -------KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAeeAKKADEAKK 1529

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1971 AlAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRAllelrSEMTAAAEERIIAVTSQKEA 2050
Cdd:PTZ00121 1530 A-EEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEE 1603

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2051 NLNVQQVVERHTRELKSQIEDLNE--------NLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKilREKDGID 2122
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEELKKaeeekkkvEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK--KKAEEAK 1681

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2123 QENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKK---VKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKwqtK 2199
Cdd:PTZ00121 1682 KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKaeeLKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKK---K 1758

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 568967306 2200 VEGLRnRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTT 2245
Cdd:PTZ00121 1759 IAHLK-KEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDI 1803
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1269-1806 1.12e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1269 SNLEHLEcENASLKEQMEAISKELEITK--EKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELN 1346
Cdd:COG1196   200 RQLEPLE-RQAEKAERYRELKEELKELEaeLLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEE 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1347 ERQRAEHCQKMYEHLRTSLKQME-------ERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILEL 1419
Cdd:COG1196   279 LELELEEAQAEEYELLAELARLEqdiarleERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1420 EKSEVELKvEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKL 1499
Cdd:COG1196   359 ELAEAEEA-LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1500 ESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRqfsgalpLAQQEKFSKTMIQLQNDKLKIM 1579
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE-------AAARLLLLLEAEADYEGFLEGV 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1580 QEMKNSQQ---------EHRNMENKTLELELKLKGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEI 1650
Cdd:COG1196   511 KAALLLAGlrglagavaVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAA 590

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1651 KYLNNIISEYEHTINSLEEEivqqskfHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGSMPDpSLPLPNQ 1730
Cdd:COG1196   591 ALARGAIGAAVDLVASDLRE-------ADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEG-GSAGGSL 662

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306 1731 LEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELE 1806
Cdd:COG1196   663 TGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738
PTZ00121 PTZ00121
MAEBL; Provisional
 16-422 1.19e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.30  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   16 DDLPRQEELadKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLE 95
Cdd:PTZ00121 1549 DELKKAEEL--KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK 1626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   96 NELEMaqqsaggrdtrflRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIID 175
Cdd:PTZ00121 1627 KAEEE-------------KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  176 YQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKiEVQNQEMRKNLEESVQEMEKMTDEYNRMKA 255
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED-KKKAEEAKKDEEEKKKIAHLKKEEEKKAEE 1772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  256 LVHQSDAVMDQ-IKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMlqsLRGKLKNA 334
Cdd:PTZ00121 1773 IRKEKEAVIEEeLDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNM---QLEEADAF 1849

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  335 QLDADKSNIMALKQGIQERDSQIKmlTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNfYQQTHYMKIHSKVQILEEKT 414
Cdd:PTZ00121 1850 EKHKFNKNNENGEDGNKEADFNKE--KDLKEDDEEEIEEADEIEKIDKDDIEREIPNNN-MAGKNNDIIDDKLDKDEYIK 1926


                  ....*...
gi 568967306  415 KEAERIAE 422
Cdd:PTZ00121 1927 RDAEETRE 1934
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1343-2168 1.27e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 50.89  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1343 KELNERQRAEHCQKMYehLRTSLkqmeernFELETKFTELtkinldaqkveQMLRDELADsVTKAVSDADRQRILELEKS 1422
Cdd:pfam15921   92 RRLNESNELHEKQKFY--LRQSV-------IDLQTKLQEM-----------QMERDAMAD-IRRRESQSQEDLRNQLQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1423 EVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKaliakLHQHVvSLQISEATALGKleSV 1502
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK-----IYEHD-SMSTMHFRSLGS--AI 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1503 TSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQF--------SGALPLAQQEKFSKTMIQLQnd 1574
Cdd:pfam15921  223 SKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLiseheveiTGLTEKASSARSQANSIQSQ-- 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1575 kLKIMQEmknsqqehrNMENKTLELELKLKGLEELISTLK-DARGAQKVinWHVKIEELRLQELKLNRELVKGKEEIKYL 1653
Cdd:pfam15921  301 -LEIIQE---------QARNQNSMYMRQLSDLESTVSQLRsELREAKRM--YEDKIEELEKQLVLANSELTEARTERDQF 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1654 N----NIISEYEHTINSLEEEIVQQSKFHEERQMAWDqREVELERQLDIFDHQQNEILSAAQKFEDSTGSMPDPSLPLPN 1729
Cdd:pfam15921  369 SqesgNLDDQLQKLLADLHKREKELSLEKEQNKRLWD-RDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQME 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1730 QLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELrlrlpatadreklIAELERKElepks 1809
Cdd:pfam15921  448 RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDL-------------TASLQEKE----- 509

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1810 hHTMKIAHQTIANMQARLNHKeevLKKYQHLlekareeqreivkKHEEDlHVLHHKLEQQADNSLNKFRQTAQDLLKQsp 1889
Cdd:pfam15921  510 -RAIEATNAEITKLRSRVDLK---LQELQHL-------------KNEGD-HLRNVQTECEALKLQMAEKDKVIEILRQ-- 569

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1890 apvptnkhfiRLAEMEQTVAEQDDSLSSLLTKLKKVSKDL-EKQKEITELKV-REFENTKLRLQETHASE---------- 1957
Cdd:pfam15921  570 ----------QIENMTQLVGQHGRTAGAMQVEKAQLEKEInDRRLELQEFKIlKDKKDAKIRELEARVSDlelekvklvn 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1958 --------VKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEaNSRAPTTTMRNLVDRLKSQLalkEKQQKALSRALLEL 2029
Cdd:pfam15921  640 agserlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKR-NFRNKSEEMETTTNKLKMQL---KSAQSELEQTRNTL 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2030 RSEMTAAAEERIIAVTSQKEANLNvqqvverhtrelKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELqkkqk 2109
Cdd:pfam15921  716 KSMEGSDGHAMKVAMGMQKQITAK------------RGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQEL----- 778

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2110 ayNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSL-IDELQKKVKKLESQLER 2168
Cdd:pfam15921  779 --STVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLqFAECQDIIQRQEQESVR 836
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1241-1550 1.82e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.32  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1241 ELANKQYNELTTKYRDILQKdnmLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQEtklgndsnmdK 1320
Cdd:COG1196   221 ELKELEAELLLLKLRELEAE---LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEA----------Q 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1321 AKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDEL 1400
Cdd:COG1196   288 AEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1401 ADSVTKAVS-----DADRQRILELEKSEVELKVEVSKL-REISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDE 1474
Cdd:COG1196   368 LEAEAELAEaeeelEELAEELLEALRAAAELAAQLEELeEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA 447

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306 1475 KALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALyyARLEGRNRAKHLRQTIQSLRR 1550
Cdd:COG1196   448 AEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE--ADYEGFLEGVKAALLLAGLRG 521
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2001-2665 1.85e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2001 MRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEEriIAVTSQKEANLNVQQVVErhtrelKSQIEDLNENLLKLK 2080
Cdd:TIGR04523   38 LEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNK--IKILEQQIKDLNDKLKKN------KDKINKLNSDLSKIN 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2081 EALKTSKNKENSLADDLNELNNELQKKQKAYNKIL----REKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQ 2156
Cdd:TIGR04523  110 SEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLteikKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNI 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2157 KKVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGKKWQTK-VEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEK 2235
Cdd:TIGR04523  190 DKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDnIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQL 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2236 LTLQKKLKTTGMTVDQvlgvralesekeleeLKKKNLDLENDILYMRTQQAlprDSVVEDLHLQNKYLQEKLHTLEKKLS 2315
Cdd:TIGR04523  270 SEKQKELEQNNKKIKE---------------LEKQLNQLKSEISDLNNQKE---QDWNKELKSELKNQEKKLEEIQNQIS 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2316 K-EKYSQSLTSEIESddhcqkeqeLQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQ 2394
Cdd:TIGR04523  332 QnNKIISQLNEQISQ---------LKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQN 402

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2395 VRgagrsgKTIPELEKTIGLMKKVVEKVQRENEQLkKASGILTSEKMATIEEENRNLKAELEKLKAhFGRQLSMQFESKN 2474
Cdd:TIGR04523  403 QE------KLNQQKDEQIKKLQQEKELLEKEIERL-KETIIKNNSEIKDLTNQDSVKELIIKNLDN-TRESLETQLKVLS 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2475 KGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEgADSKSWKSIVVSRVYE 2554
Cdd:TIGR04523  475 RSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKE-SKISDLEDELNKDDFE 553

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2555 TKMKELESDIAKKNQSITDLKQ----LVREATEREQKAKKYTED-------LEQQIEILKNVPEGAETEQELIRELQLLR 2623
Cdd:TIGR04523  554 LKKENLEKEIDEKNKEIEELKQtqksLKKKQEEKQELIDQKEKEkkdlikeIEEKEKKISSLEKELEKAKKENEKLSSII 633

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 568967306  2624 LANNQMDKERAELIHQIEINKDQTRADSSIPDSD--QLKEKIND 2665
Cdd:TIGR04523  634 KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKikESKTKIDD 677
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 199-553 2.27e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 2.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   199 SQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQV 278
Cdd:TIGR02168  691 EKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   279 RELTDLLKAKDEEddpvMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKS--NIMALKQGIQERDSQ 356
Cdd:TIGR02168  771 EEAEEELAEAEAE----IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLerRIAATERRLEDLEEQ 846

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   357 IKMLTEQVEQYTKEMEKNTFIIEDLKNELQKdKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELV 436
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELESELEA-LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA 925

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   437 EALKRLKDYESGVYGL-----EDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALreraglepktmidL 511
Cdd:TIGR02168  926 QLELRLEGLEVRIDNLqerlsEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAA-------------I 992

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 568967306   512 TEFrnskrlkqQQYRAENQVLLKEIESLEEERLDLKRKIRQM 553
Cdd:TIGR02168  993 EEY--------EELKERYDFLTAQKEDLTEAKETLEEAIEEI 1026
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 78-233 2.29e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.07  E-value: 2.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    78 EEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF--LRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEA 155
Cdd:TIGR02169  346 EEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFaeTRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADL 425

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568967306   156 ENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMR 233
Cdd:TIGR02169  426 NAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASE 503
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 113-458 2.39e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEK--ELDKEKKV--NEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLL 188
Cdd:COG1196   191 LEDILGELERQLEPLERQAEKAERyrELKEELKEleAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  189 SRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIK 268
Cdd:COG1196   271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  269 KENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEwkliLSSKDDEIIEYQQMLQSLRGKLKNAQLDADK--SNIMAL 346
Cdd:COG1196   351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE----LLEALRAAAELAAQLEELEEAEEALLERLERleEELEEL 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  347 KQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQthymkihSKVQILEEKTKEAERIAELAEA 426
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA-------ALAELLEELAEAAARLLLLLEA 499

                         330       340       350
                  ....*....|....*....|....*....|..
gi 568967306  427 DAREKDKELVEALKRLKDYESGVYGLEDAVIE 458
Cdd:COG1196   500 EADYEGFLEGVKAALLLAGLRGLAGAVAVLIG 531
PTZ00121 PTZ00121
MAEBL; Provisional
 79-631 2.63e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   79 EQAKFENQLKTKVMKLENELEMAQQSAGGrdtrfLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENE 158
Cdd:PTZ00121 1305 DEAKKKAEEAKKADEAKKKAEEAKKKADA-----AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKK 1379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  159 NSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEvqnqEMRKNLEE 238
Cdd:PTZ00121 1380 ADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKAD----EAKKKAEE 1455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  239 S--VQEMEKMTDEYNRMKALVHQSDAV--MDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSS-- 312
Cdd:PTZ00121 1456 AkkAEEAKKKAEEAKKADEAKKKAEEAkkADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAkk 1535

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  313 -----------KDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYtkEMEKNTFIIEDL 381
Cdd:PTZ00121 1536 adeakkaeekkKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY--EEEKKMKAEEAK 1613

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  382 KNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAE---------RIAELAEADAREKDKELVEALKRLKDYESGVYGL 452
Cdd:PTZ00121 1614 KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEelkkaeeenKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  453 EDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEmKINDIldENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAEN--- 529
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEAEEKKKAEELKKAE-EENKI--KAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEkka 1770

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  530 QVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASgltiddlnlsetfSHENKIEGRKLNFMSLNNMNETQ-SKIKSSAK 608
Cdd:PTZ00121 1771 EEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFD-------------NFANIIEGGKEGNLVINDSKEMEdSAIKEVAD 1837

                         570       580
                  ....*....|....*....|...
gi 568967306  609 TELLHRRPSFSVVQSDQSEAEEN 631
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKNNEN 1860
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 30-493 2.98e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.63  E-value: 2.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    30 ISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEvekagEEQAKFENQLKTKVMKLENELEMAQQSAGGRD 109
Cdd:TIGR04523  234 IEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKEL-----EQNNKKIKELEKQLNQLKSEISDLNNQKEQDW 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   110 TRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLS 189
Cdd:TIGR04523  309 NKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKN 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   190 RRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKK 269
Cdd:TIGR04523  389 LESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLET 468

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   270 ENEHYRLQVRELTDLLKAKDEEDdpvmmavnakveewklilsskddeiieyqqmlqslrgKLKNAQLDADKSNIMALKQG 349
Cdd:TIGR04523  469 QLKVLSRSINKIKQNLEQKQKEL-------------------------------------KSKEKELKKLNEEKKELEEK 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   350 IQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQ-QTHYMKIHSKVQILEEKTKEAERIAELAEADA 428
Cdd:TIGR04523  512 VKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENlEKEIDEKNKEIEELKQTQKSLKKKQEEKQELI 591

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967306   429 REKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDE 493
Cdd:TIGR04523  592 DQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKE 656
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2034-2235 3.23e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 3.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2034 TAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNK 2113
Cdd:COG3883    11 PAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2114 ILRE--KDGIDQ-------ENDELRRQIKRLSSglqSKTLIDNKQSLIDELQKKVKKLE---SQLERKVDDVDIKPVKEK 2181
Cdd:COG3883    91 RARAlyRSGGSVsyldvllGSESFSDFLDRLSA---LSKIADADADLLEELKADKAELEakkAELEAKLAELEALKAELE 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568967306 2182 SSKEELIRWEEGKkwQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEK 2235
Cdd:COG3883   168 AAKAELEAQQAEQ--EALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1748-2561 4.37e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 49.27  E-value: 4.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1748 TQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPkSHHTMKIAHQTIANMQARL 1827
Cdd:TIGR00606  236 SREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKV-FQGTDEQLNDLYHNHQRTV 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1828 NHKEEVLKKYQHLLEKAREEQREIVKKHEEdLHVLHHKLEQQADNSLNKFRqtAQDLLKQSPAPVP-------------- 1893
Cdd:TIGR00606  315 REKERELVDCQRELEKLNKERRLLNQEKTE-LLVEQGRLQLQADRHQEHIR--ARDSLIQSLATRLeldgfergpfserq 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1894 -TNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLqETHASEVKKVKAEVEDLRHAL 1972
Cdd:TIGR00606  392 iKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEIL-EKKQEELKFVIKELQQLEGSS 470

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1973 AQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAvTSQKEANL 2052
Cdd:TIGR00606  471 DRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLT-KDKMDKDE 549

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2053 NVQQVVERHTRELKSQIEDLnENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKD------------- 2119
Cdd:TIGR00606  550 QIRKIKSRHSDELTSLLGYF-PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELEskeeqlssyedkl 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2120 ----GIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDE--------------LQKKVKKLESQLERKVDDVDIK----P 2177
Cdd:TIGR00606  629 fdvcGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQfitqltdenqsccpVCQRVFQTEAELQEFISDLQSKlrlaP 708

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2178 VKEKSSKEELIRWE-EGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKaDKEKLTLQKKLKTTGMTVDQVLGVr 2256
Cdd:TIGR00606  709 DKLKSTESELKKKEkRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQR-LKNDIEEQETLLGTIMPEEESAKV- 786

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2257 ALESEKELEELKKKNLDLENDIlymrTQQALPRDSVVEDLHLQ--NKYLQEKLHTLEKKLSKEKYSQSLtseieSDDHCQ 2334
Cdd:TIGR00606  787 CLTDVTIMERFQMELKDVERKI----AQQAAKLQGSDLDRTVQqvNQEKQEKQHELDTVVSKIELNRKL-----IQDQQE 857

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2335 KEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLE-----------LERKLGQVRGAGRSGK 2403
Cdd:TIGR00606  858 QIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQdspletflekdQQEKEELISSKETSNK 937

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2404 TI--------PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEE-------NRNLKAELEKLKAHFGRQLSM 2468
Cdd:TIGR00606  938 KAqdkvndikEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECekhqekiNEDMRLMRQDIDTQKIQERWL 1017

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2469 QFESKNKGTEKIVAENERLRKELKKEI-------------EASEKLRIAKNNLELVNDKMAAQLEEtgKRLQFAESRAPQ 2535
Cdd:TIGR00606 1018 QDNLTLRKRENELKEVEEELKQHLKEMgqmqvlqmkqehqKLEENIDLIKRNHVLALGRQKGYEKE--IKHFKKELREPQ 1095

                          890       900
                   ....*....|....*....|....*.
gi 568967306  2536 LEGADSKSWKSIVVSRVYETKMKELE 2561
Cdd:TIGR00606 1096 FRDAEEKYREMMIVMRTTELVNKDLD 1121
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2104-2675 4.47e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.29  E-value: 4.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2104 LQKKQKAYNKILREKDGIDQENDELRRQIKRLSsglQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVD--------- 2174
Cdd:PRK03918  157 LDDYENAYKNLGEVIKEIKRRIERLEKFIKRTE---NIEELIKEKEKELEEVLREINEISSELPELREELEklekevkel 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2175 --IKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELfaKADKEKLTLQKKLKTTGMTVDQV 2252
Cdd:PRK03918  234 eeLKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEYLDELRE 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2253 LGVRALESEKELEELKKKNLDLENDilymrtqqalprDSVVEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIE---S 2329
Cdd:PRK03918  312 IEKRLSRLEEEINGIEERIKELEEK------------EERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELErlkK 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2330 DDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELE---RKLGQVRGAGRSGKTIP 2406
Cdd:PRK03918  380 RLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPvcgRELTEEHRKELLEEYTA 459

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2407 ELEKTIGLMKKVVEKVQRENEQLKKASGILTSE----KMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVA 2482
Cdd:PRK03918  460 ELKRIEKELKEIEEKERKLRKELRELEKVLKKEseliKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKG 539

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2483 ENERLRKELKKEIEASEKLRIAKNNLELVNDKMAA---QLEETG-KRLQFAESRAPQLEGADSKSwksivvsrvyeTKMK 2558
Cdd:PRK03918  540 EIKSLKKELEKLEELKKKLAELEKKLDELEEELAEllkELEELGfESVEELEERLKELEPFYNEY-----------LELK 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2559 ELESDIAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNvpEGAETEQELIRELQLlrlannQMDKERAELIH 2638
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEK--KYSEEEYEELREEYL------ELSRELAGLRA 680

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 568967306 2639 QIEINKDqtRADSSIPDSDQLKEKINDLETQLRKLEL 2675
Cdd:PRK03918  681 ELEELEK--RREEIKKTLEKLKEELEEREKAKKELEK 715
PTZ00121 PTZ00121
MAEBL; Provisional
 2312-2734 4.66e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 4.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2312 KKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKlELERK 2391
Cdd:PTZ00121 1348 AKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKK 1426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2392 LGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQlKKASGILTSEKMATIEEENRNL-----KAELEKLKAHFGRQL 2466
Cdd:PTZ00121 1427 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAK-KKAEEAKKADEAKKKAEEAKKAdeakkKAEEAKKKADEAKKA 1505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2467 S---------MQFESKNKGTEKIVAENERLRKELKK--EIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQ 2535
Cdd:PTZ00121 1506 AeakkkadeaKKAEEAKKADEAKKAEEAKKADEAKKaeEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2536 LEGADSKSWKSIVVSRVYETKMKELEsdiAKKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEgaETEQEL 2615
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYEEEKKMKAEE---AKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKK--AEEENK 1660

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2616 IRELQLLRLAnnQMDKERAELIHQIEinKDQTRADSSIPDSDQLKEKINDL----------------ETQLRKLELEKQH 2679
Cdd:PTZ00121 1661 IKAAEEAKKA--EEDKKKAEEAKKAE--EDEKKAAEALKKEAEEAKKAEELkkkeaeekkkaeelkkAEEENKIKAEEAK 1736

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2680 SKEEVKKLKKELENFDPSFFEEIEDLKYNYKEEVK-----KNILLEEKLKKLSEQFGFEL 2734
Cdd:PTZ00121 1737 KEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEeirkeKEAVIEEELDEEDEKRRMEV 1796
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 113-281 5.18e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 5.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESL----- 187
Cdd:COG4942    32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELaellr 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  188 -LSRRGEDSDYRSQLSKKN-------YELVQYL-----DEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMK 254
Cdd:COG4942   112 aLYRLGRQPPLALLLSPEDfldavrrLQYLKYLaparrEQAEELRADLAELAALRAELEAERAELEALLAELEEERAALE 191

                         170       180
                  ....*....|....*....|....*..
gi 568967306  255 ALVHQSDAVMDQIKKENEHYRLQVREL 281
Cdd:COG4942   192 ALKAERQKLLARLEKELAELAAELAEL 218
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1862-2134 5.22e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1862 LHHKLEQQADNSLNKFRQTaqdllkQSPAPVPTNKHFIRlAEM--EQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELk 1939
Cdd:COG4913   182 LRRRLGIGSEKALRLLHKT------QSFKPIGDLDDFVR-EYMleEPDTFEAADALVEHFDDLERAHEALEDAREQIEL- 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1940 vrefentkLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAptttmrnLVDRLKSQLALKEKQQ 2019
Cdd:COG4913   254 --------LEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRA-------ELARLEAELERLEARL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2020 KALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQI-----------EDLNENLLKLKEALKTSKN 2088
Cdd:COG4913   319 DALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLaalglplpasaEEFAALRAEAAALLEALEE 398

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568967306 2089 KENSLADDLNELNNELQKKQKAYNKILREKDG-------IDQENDELRRQIKR 2134
Cdd:COG4913   399 ELEALEEALAEAEAALRDLRRELRELEAEIASlerrksnIPARLLALRDALAE 451
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 113-291 8.10e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 8.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  113 LRDEIRQLEKQLEQKDRELEDMEKELDkekKVNEQLalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESL----- 187
Cdd:COG3883    21 KQKELSELQAELEAAQAELDALQAELE---ELNEEY----NELQAELEALQAEIDKLQAEIAEAEAEIEERREELgerar 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  188 -LSRRGEDSDYRSQL--SKKNYELVQYLDEIQTLTEANEKI-------EVQNQEMRKNLEESVQEMEKMTDEYNRMK--- 254
Cdd:COG3883    94 aLYRSGGSVSYLDVLlgSESFSDFLDRLSALSKIADADADLleelkadKAELEAKKAELEAKLAELEALKAELEAAKael 173

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568967306  255 -ALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEE 291
Cdd:COG3883   174 eAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAA 211
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1735-2501 9.68e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.04  E-value: 9.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1735 LRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMK 1814
Cdd:pfam02463  271 LKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIK 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1815 IAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKqspapvpt 1894
Cdd:pfam02463  351 REAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLK-------- 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1895 nkhfIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHasEVKKVKAEVEDLRHALAQ 1974
Cdd:pfam02463  423 ----EEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQ--LVKLQEQLELLLSRQKLE 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1975 AHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLAL-KEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLN 2053
Cdd:pfam02463  497 ERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLG 576

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2054 VQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIK 2133
Cdd:pfam02463  577 ARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEE 656

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2134 RLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVddvdIKPVKEKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEGE 2213
Cdd:pfam02463  657 GLAEKSEVKASLSELTKELLEIQELQEKAESELAKEE----ILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQD 732

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2214 AHGLAKQLNTLKELFAKADKEKLTLQKKLKttgmtvdqvlgvRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVV 2293
Cdd:pfam02463  733 KINEELKLLKQKIDEEEEEEEKSRLKKEEK------------EEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQE 800

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2294 EDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKD 2373
Cdd:pfam02463  801 EELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELE 880

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2374 LKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGL-MKKVVEKVQRENEQLKKASG--ILTSEKMATIEEENRN 2450
Cdd:pfam02463  881 EQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEErIKEEAEILLKYEEEPEELLLeeADEKEKEENNKEEEEE 960

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568967306  2451 LKAELEKLKAHFGRQLSM---QFESKNKGTEKIVAENERLRKELKKEIEASEKL 2501
Cdd:pfam02463  961 RNKRLLLAKEELGKVNLMaieEFEEKEERYNKDELEKERLEEEKKKLIRAIIEE 1014
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 149-376 1.13e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  149 ALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQ 228
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  229 NQEMRKNLEESVQEMEKMtDEYNRMKALVHQSD------------AVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVM 296
Cdd:COG4942    99 LEAQKEELAELLRALYRL-GRQPPLALLLSPEDfldavrrlqylkYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  297 MAVNAKVEEWKLILSSKDdeiiEYQQMLQSLrgklkNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTF 376
Cdd:COG4942   178 ALLAELEEERAALEALKA----ERQKLLARL-----EKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGF 248
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2099-2687 1.43e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.62  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2099 ELNNELQKKQKAYnkILREKDGIDQENDELRRQIKRLssglqsKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPV 2178
Cdd:COG1196   217 ELKEELKELEAEL--LLLKLRELEAELEELEAELEEL------EAELEELEAELAELEAELEELRLELEELELELEEAQA 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2179 KEKSSKEELIRWEEGKK-WQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMTVDQVLGVRA 2257
Cdd:COG1196   289 EEYELLAELARLEQDIArLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALL 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2258 LESEKELEELKKKNLDLENDILYMRTQQALpRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKysQSLTSEIESDDHCQKEQ 2337
Cdd:COG1196   369 EAEAELAEAEEELEELAEELLEALRAAAEL-AAQLEELEEAEEALLERLERLEEELEELEE--ALAELEEEEEEEEEALE 445

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2338 ELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGLMKK 2417
Cdd:COG1196   446 EAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGA 525

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2418 VVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAhfgrqlsmqfesKNKGTEKIVAENERLRKELKKEIEA 2497
Cdd:COG1196   526 VAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKA------------AKAGRATFLPLDKIRARAALAAALA 593

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2498 SEKLRIAKNNLELvndkmAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQL 2577
Cdd:COG1196   594 RGAIGAAVDLVAS-----DLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR 668

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2578 VREATEREQKAKKytEDLEQQIEilknvpEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQTRADSSIPDSD 2657
Cdd:COG1196   669 ELLAALLEAEAEL--EELAERLA------EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEE 740

                         570       580       590
                  ....*....|....*....|....*....|
gi 568967306 2658 QLKEKINDLETQLRKLELEKqhSKEEVKKL 2687
Cdd:COG1196   741 LLEEEELLEEEALEELPEPP--DLEELERE 768
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2486-2731 1.76e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.37  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2486 RLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIA 2565
Cdd:PRK03918  169 EVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2566 KKNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERAELIHQI----- 2640
Cdd:PRK03918  249 SLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEIngiee 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2641 ---EINKDQTRADSSIPDSDQLKEKINDLETQLRKLELEKQHSKEEVKKLKKELEnfdpsffEEIEDLKYNYKEEVKKNI 2717
Cdd:PRK03918  329 rikELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTG-------LTPEKLEKELEELEKAKE 401

                         250
                  ....*....|....
gi 568967306 2718 LLEEKLKKLSEQFG 2731
Cdd:PRK03918  402 EIEEEISKITARIG 415
PTZ00121 PTZ00121
MAEBL; Provisional
 1067-1651 2.76e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1067 QELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLED--QAEQDAVKVKEYNNLLS 1144
Cdd:PTZ00121 1246 EEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEakKKAEEAKKADEAKKKAE 1325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1145 ALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMER--HLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIF 1222
Cdd:PTZ00121 1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEaaEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKK 1405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1223 KIAALQKVidnsvslselELANKQYNELTTKYRDILQKDnmlvqrtsnlehlecenaSLKEQMEAISKELEItKEKLHTI 1302
Cdd:PTZ00121 1406 KADELKKA----------AAAKKKADEAKKKAEEKKKAD------------------EAKKKAEEAKKADEA-KKKAEEA 1456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1303 EQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSlkqmEERNFELETKFTEL 1382
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKA----EEAKKADEAKKAEE 1532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1383 TKINLDAQKVEQMLRdelADSVTKAVsdadrqrilELEKSEVELKVE-VSKLREISDIAKRQVDFLNSQQQSREKEVESL 1461
Cdd:PTZ00121 1533 AKKADEAKKAEEKKK---ADELKKAE---------ELKKAEEKKKAEeAKKAEEDKNMALRKAEEAKKAEEARIEEVMKL 1600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1462 RTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL 1541
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEA 1680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1542 RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRnmeNKTLELELKLKGLEELISTLKDARGAQK 1621
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENK---IKAEEAKKEAEEDKKKAEEAKKDEEEKK 1757

                         570       580       590
                  ....*....|....*....|....*....|
gi 568967306 1622 VINWHVKIEELRLQELKLNRELVKgKEEIK 1651
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEIRKEKEAVI-EEELD 1786
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 120-491 3.12e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.17  E-value: 3.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   120 LEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQ---IDSQKESLLSRRGEDSD 196
Cdd:TIGR04523  361 KQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEkelLEKEIERLKETIIKNNS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   197 YRSQLSKKNYELVQYLDEIQTLTEANEK----IEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENE 272
Cdd:TIGR04523  441 EIKDLTNQDSVKELIIKNLDNTRESLETqlkvLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKIS 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   273 HYRLQVRELTDLLKAKDE-----EDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADK--SNIMA 345
Cdd:TIGR04523  521 SLKEKIEKLESEKKEKESkisdlEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQkeKEKKD 600

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   346 LKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAE 425
Cdd:TIGR04523  601 LIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIE 680

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306   426 ADAREKDKELVEALKRLKDyESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDIL 491
Cdd:TIGR04523  681 LMKDWLKELSLHYKKYITR-MIRIKDLPKLEEKYKEIEKELKKLDEFSKELENIIKNFNKKFDDAF 745
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 223-500 3.20e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   223 EKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDdpvMMAVNAK 302
Cdd:TIGR02169  219 EKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEE---QLRVKEK 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   303 VEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSnimalkqgiqerDSQIKMLTEQVEQYTKEMEKNTFIIEDLK 382
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKL------------LAEIEELEREIEEERKRRDKLTEEYAELK 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   383 NElqkdkgtsnfyqqthYMKIHSKVQILEEKTKEA-ERIAELAEA--DAREKDKELVEALKRLKDYESGVYG-LEDAVIE 458
Cdd:TIGR02169  364 EE---------------LEDLRAELEEVDKEFAETrDELKDYREKleKLKREINELKRELDRLQEELQRLSEeLADLNAA 428

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 568967306   459 IKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRER 500
Cdd:TIGR02169  429 IAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQE 470
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 877-1697 3.52e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   877 LDHQRSQAEQNEFLSRELAEKEK-----DLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKdmpkdsdvkggETS 951
Cdd:TIGR02168  205 LERQAEKAERYKELKAELRELELallvlRLEELREELEELQEELKEAEEELEELTAELQELEEKLE-----------ELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   952 LIIPSLERLVNAMESKNAEgifdaslhLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQS 1031
Cdd:TIGR02168  274 LEVSELEEEIEELQKELYA--------LANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEK 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1032 AGSnvvykgidlpdgiapsSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLykeylsEKDIW 1111
Cdd:TIGR02168  346 LEE----------------LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL------NNEIE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1112 KTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKE 1191
Cdd:TIGR02168  404 RLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1192 NGKHRNDVIAMEAEVTEKLGSLQRFKE--MAIFKIAALQKVIDNSVSL-SELELA-------NKQY---NELTTKYRDI- 1257
Cdd:TIGR02168  484 LAQLQARLDSLERLQENLEGFSEGVKAllKNQSGLSGILGVLSELISVdEGYEAAieaalggRLQAvvvENLNAAKKAIa 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1258 ------LQKDNMLVQRTSNLEHLECENASLKEQME---AISKELEITKEKLHTIEQAWEQETKLGND--SNMDKAKKSMT 1326
Cdd:TIGR02168  564 flkqneLGRVTFLPLDSIKGTEIQGNDREILKNIEgflGVAKDLVKFDPKLRKALSYLLGGVLVVDDldNALELAKKLRP 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1327 NSDIVS-----------ISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQM 1395
Cdd:TIGR02168  644 GYRIVTldgdlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEE 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1396 LRDELADsvTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQ-SDE 1474
Cdd:TIGR02168  724 LSRQISA--LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEElKAL 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1475 KALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALyyarlegrNRAKHLRQTIQSLRRQFSG 1554
Cdd:TIGR02168  802 REALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDI--------ESLAAEIEELEELIEELES 873

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1555 ALplaqqEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKtlelelklkgleelistLKDARGAQKVINWHVKIEELRL 1634
Cdd:TIGR02168  874 EL-----EALLNERASLEEALALLRSELEELSEELRELESK-----------------RSELRRELEELREKLAQLELRL 931

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967306  1635 QELKLNRELVKGKeeikylnnIISEYEHTinslEEEIVQQSKFHEERQMAWDQREVELERQLD 1697
Cdd:TIGR02168  932 EGLEVRIDNLQER--------LSEEYSLT----LEEAEALENKIEDDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 230-1146 1.02e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   230 QEMRKNLEESVQEMEKMTD---EYNR-MKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEE 305
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDilnELERqLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   306 wkliLSSKDDEIIEYQQMLQSLRGKL--KNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKN 383
Cdd:TIGR02168  255 ----LEELTAELQELEEKLEELRLEVseLEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   384 ELQKDKgtsnfyqqthymkihSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNck 463
Cdd:TIGR02168  331 KLDELA---------------EELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL-- 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   464 aqikirdgEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIdltefRNSKRLKQQQYRAENQVLLKEIESLEEER 543
Cdd:TIGR02168  394 --------QIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE-----EAELKELQAELEELEEELEELQEELERLE 460

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   544 LDLKRKIRQMAQERGKRNAAsgltiddlnlsetfshENKIEGRKLNFMSLNNMNETQSKIKSSAKTELLHRRpsfsvvqs 623
Cdd:TIGR02168  461 EALEELREELEEAEQALDAA----------------ERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS-------- 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   624 dqseaeenmatrslsrMLSGIHQSVgsagdpivsltrcSSFMQVKDSSATPEAITIREIFKAPCLRSLRKLESLVSTFSK 703
Cdd:TIGR02168  517 ----------------GLSGILGVL-------------SELISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQ 567

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   704 DGSEELSEYLCSLSDDHMKRGSGNHRGLEKTRFLQKSSSSFQVSPAAAELMQKLSHRQS------SAIFPQQSYDRDVDK 777
Cdd:TIGR02168  568 NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLvvddldNALELAKKLRPGYRI 647

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   778 VTSEDNQVYSqieHAVLSLKDDKGQSELPSQT---EMLSSKTQVNLSDLVPITAQskpslIHPLEKLIGQPQRQLAFLRS 854
Cdd:TIGR02168  648 VTLDGDLVRP---GGVITGGSAKTNSSILERRreiEELEEKIEELEEKIAELEKA-----LAELRKELEELEEELEQLRK 719

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   855 QNETIVQDLPIQEEQSRNAELEldhQRSQAEQNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQ 934
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAE---VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   935 AIKDMPKDSDVKGGETSLIIPSLERLVNAMESknaegifdaslhLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKA 1014
Cdd:TIGR02168  797 ELKALREALDELRAELTLLNEEAANLRERLES------------LERRIAATERRLEDLEEQIEELSEDIESLAAEIEEL 864

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1015 NLKIDHLEKETD-LLRQSAGSNVVYKgidlpdgiapssayIINSQNEYLIHLLQELDNK----EKKLKHLEDSLEDYNRK 1089
Cdd:TIGR02168  865 EELIEELESELEaLLNERASLEEALA--------------LLRSELEELSEELRELESKrselRRELEELREKLAQLELR 930

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568967306  1090 FAVIRhQQSLLYKEYLSEKdiWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSAL 1146
Cdd:TIGR02168  931 LEGLE-VRIDNLQERLSEE--YSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2017-2246 1.10e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2017 KQQKALSRALLELRSEMtaAAEERIIAVTSQKEANLNVQqvverhTRELKSQIEDLNENLLKLKEALKTSKNKENSLADD 2096
Cdd:COG4942    20 DAAAEAEAELEQLQQEI--AELEKELAALKKEEKALLKQ------LAALERRIAALARRIRALEQELAALEAELAELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2097 LNELNNELQKKQKAYNKILREKDGIDQEN--------DELRRQIKRLSSglqSKTLIDNKQSLIDELQKKVKKLESQLER 2168
Cdd:COG4942    92 IAELRAELEAQKEELAELLRALYRLGRQPplalllspEDFLDAVRRLQY---LKYLAPARREQAEELRADLAELAALRAE 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967306 2169 KVDDVDIKPVKEKSSKEELIRWEEGKKWQTK-VEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTG 2246
Cdd:COG4942   169 LEAERAELEALLAELEEERAALEALKAERQKlLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 52-252 1.12e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 44.25  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    52 FRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ-----LKTKVMKLENELEMAQQsaggrDTRFLRDEIRQLEKQLEQ 126
Cdd:pfam05667  300 FTHTEKLQFTNEAPAATSSPPTKVETEEELQQQREeeleeLQEQLEDLESSIQELEK-----EIKKLESSIKQVEEELEE 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   127 KDRELEDMEKELDKEKKVNEQLalrnEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSrrgEDSDYRSQLSKKNY 206
Cdd:pfam05667  375 LKEQNEELEKQYKVKKKTLDLL----PDAEENIAKLQALVDASAQRLVELAGQWEKHRVPLIE---EYRALKEAKSNKED 447

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 568967306   207 ELVQYLDEIQTLteaNEKIEVQNQEMRKNLEESVQ---EMEKMTDEYNR 252
Cdd:pfam05667  448 ESQRKLEEIKEL---REKIKEVAEEAKQKEELYKQlvaEYERLPKDVSR 493
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2009-2172 1.12e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2009 KSQLALKEKQQKALSRALLELRSEMTAAAEERIiAVTSQKEANLNVQQV---------VERHTRELKSQIEDLNENLLKL 2079
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELD-ALQERREALQRLAEYswdeidvasAEREIAELEAELERLDASSDDL 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2080 KEalktsknkensLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQS------------------ 2141
Cdd:COG4913   688 AA-----------LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaedlarlelralleerfa 756

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 568967306 2142 --------KTLIDNKQSLIDELQKKVKKLESQLERKVDD 2172
Cdd:COG4913   757 aalgdaveRELRENLEERIDALRARLNRAEEELERAMRA 795
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
 82-191 1.29e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 43.56  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   82 KFENQLKTKV-----MKL--------------ENELEMAQQSAGGRDTRFLRdEIRQLEKQLEQKDRELEDMEKELDKEK 142
Cdd:COG4026    77 KFFEELKGMVghverMKLplghdveyvdvelvRKEIKNAIIRAGLKSLQNIP-EYNELREELLELKEKIDEIAKEKEKLT 155

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568967306  143 KVNEQLALRNEEAENENSKLRRENEQLRQD---IIDYQKQIDSQKESLLSRR 191
Cdd:COG4026   156 KENEELESELEELREEYKKLREENSILEEEfdnIKSEYSDLKSRFEELLKKR 207
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2124-2733 1.29e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2124 ENDELRRQIKRLSSGLQS-KTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKsskeeliRWEEGKKWQTKVEG 2202
Cdd:PRK03918  142 ESDESREKVVRQILGLDDyENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEK-------ELEEVLREINEISS 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2203 LRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTtgmtvdqvlgvralesekeleelkkknldLENDILYMR 2282
Cdd:PRK03918  215 ELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRK-----------------------------LEEKIRELE 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2283 TQqalprdsvVEDLHLQNKYLQEKLHTLEKklSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANK 2362
Cdd:PRK03918  266 ER--------IEELKKEIEELEEKVKELKE--LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEE 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2363 D---LPRLKNQVKDLKEMCEFLKKGKLELER---KLGQVRG--AGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKkasg 2434
Cdd:PRK03918  336 KeerLEELKKKLKELEKRLEELEERHELYEEakaKKEELERlkKRLTGLTPEKLEKELEELEKAKEEIEEEISKIT---- 411

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2435 iltsEKMATIEEENRNLKAELEKLKAH------FGRQLSMqfESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNL 2508
Cdd:PRK03918  412 ----ARIGELKKEIKELKKAIEELKKAkgkcpvCGRELTE--EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL 485

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2509 E--LVNDKMAAQLEETGKRLQFAESRapqLEGADSKSWKSivVSRVYET---KMKELESDIAKKNQSITDLKQLVREATE 2583
Cdd:PRK03918  486 EkvLKKESELIKLKELAEQLKELEEK---LKKYNLEELEK--KAEEYEKlkeKLIKLKGEIKSLKKELEKLEELKKKLAE 560

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2584 REQKAKKYTEDLEQQIEILKNvpEGAETEQELIRELQLLRlannqmdkeraelihqiEINKDQTRADSSIPDSDQLKEKI 2663
Cdd:PRK03918  561 LEKKLDELEEELAELLKELEE--LGFESVEELEERLKELE-----------------PFYNEYLELKDAEKELEREEKEL 621

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2664 NDLETQLRKLELEKQHSKEEVKKLKkelenfdpsffEEIEDLKYNYKEEVKKNIlLEEKLKKLSEQFGFE 2733
Cdd:PRK03918  622 KKLEEELDKAFEELAETEKRLEELR-----------KELEELEKKYSEEEYEEL-REEYLELSRELAGLR 679
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 130-173 1.37e-03

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 43.67  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568967306  130 ELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDI 173
Cdd:PRK03992    2 RLEALEERNSELEEQIRQLELKLRDLEAENEKLERELERLKSEL 45
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
93-564 1.60e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   93 KLENELEMAQQSAGGRDTRFLrDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLalrnEEAENENSKLRRENEQLRQD 172
Cdd:COG4717    50 RLEKEADELFKPQGRKPELNL-KELKELEEELKEAEEKEEEYAELQEELEELEEEL----EELEAELEELREELEKLEKL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  173 IidyqkqidsQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEE--------SVQEME 244
Cdd:COG4717   125 L---------QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEElleqlslaTEEELQ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  245 KMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQML 324
Cdd:COG4717   196 DLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTI 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  325 QSLRGKLknAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIH 404
Cdd:COG4717   276 AGVLFLV--LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELL 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  405 SKVQILEEKTK----EAERIAELAEADArEKDKELVEALKRLKDYESGVYGLEDAVIEI--KNCKAQIKIRDGEMEVLTK 478
Cdd:COG4717   354 REAEELEEELQleelEQEIAALLAEAGV-EDEEELRAALEQAEEYQELKEELEELEEQLeeLLGELEELLEALDEEELEE 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  479 EINKLEMKINDILDENEALRERAGlepktmidltefrnskRLKQQQYRAENQvllKEIESLEEERLDLKRKIRQMAQERG 558
Cdd:COG4717   433 ELEELEEELEELEEELEELREELA----------------ELEAELEQLEED---GELAELLQELEELKAELRELAEEWA 493


                  ....*.
gi 568967306  559 KRNAAS 564
Cdd:COG4717   494 ALKLAL 499
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1916-2168 1.70e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1916 SSLLTKLKKVSKD-LEKQKEITELKVREFE-NTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEAN 1993
Cdd:TIGR04523  169 EELENELNLLEKEkLNIQKNIDKIKNKLLKlELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1994 SRAPT--TTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEErIIAVTSQKEANLNVQ-----QVVERHTRELK 2066
Cdd:TIGR04523  249 SNTQTqlNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSE-ISDLNNQKEQDWNKElkselKNQEKKLEEIQ 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2067 SQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQS-KTLI 2145
Cdd:TIGR04523  328 NQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNqEKLN 407

                          250       260
                   ....*....|....*....|...
gi 568967306  2146 DNKQSLIDELQKKVKKLESQLER 2168
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIER 430
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
116-552 1.99e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  116 EIRQLEKqLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDS 195
Cdd:PRK03918  153 QILGLDD-YENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  196 DY---RSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEE------SVQEMEKMTDEYNRMKALVHQSDAVMDQ 266
Cdd:PRK03918  232 ELeelKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEleekvkELKELKEKAEEYIKLSEFYEEYLDELRE 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  267 IKKENEHYRLQVRELTDLLKAKDEEDDPVmmavnAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQ-LDADKS--NI 343
Cdd:PRK03918  312 IEKRLSRLEEEINGIEERIKELEEKEERL-----EELKKKLKELEKRLEELEERHELYEEAKAKKEELErLKKRLTglTP 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  344 MALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLK---NELQKDKGTSNFYQQThyMKIHSKVQILEEKTKEAERI 420
Cdd:PRK03918  387 EKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKkaiEELKKAKGKCPVCGRE--LTEEHRKELLEEYTAELKRI 464

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  421 A-ELAEADAREKD--KELVEALKRLKDyESGVYGLEDAVIEIKNCKAQIKIRDGE-MEVLTKEINKLEMKINDILDENEA 496
Cdd:PRK03918  465 EkELKEIEEKERKlrKELRELEKVLKK-ESELIKLKELAEQLKELEEKLKKYNLEeLEKKAEEYEKLKEKLIKLKGEIKS 543

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306  497 LRERAGlepktmidltefrnskrlKQQQYRAENQVLLKEIESLEEERLDLKRKIRQ 552
Cdd:PRK03918  544 LKKELE------------------KLEELKKKLAELEKKLDELEEELAELLKELEE 581
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 108-547 2.38e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   108 RDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRENEQLRQDIIDYQKQIDSQKESL 187
Cdd:TIGR04523  103 SDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   188 LSRRGEDSDYRSQLSKKNYEL---VQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVM 264
Cdd:TIGR04523  183 LNIQKNIDKIKNKLLKLELLLsnlKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   265 DQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAV----NAKVEEW----KLILSSKDDEIIEYQ-------QMLQSLRG 329
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEIsdlnNQKEQDWnkelKSELKNQEKKLEEIQnqisqnnKIISQLNE 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   330 KLKN--AQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQthymKIHSKV 407
Cdd:TIGR04523  343 QISQlkKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDE----QIKKLQ 418

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   408 QILEEKTKEAERIAELAE------ADAREKDKELVEALKRLKDYEsgvyglEDAVIEIKNCKAQIKIRDGEMEVLTKEIN 481
Cdd:TIGR04523  419 QEKELLEKEIERLKETIIknnseiKDLTNQDSVKELIIKNLDNTR------ESLETQLKVLSRSINKIKQNLEQKQKELK 492

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306   482 KLEMKINDILDENEALRERaglepktMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLK 547
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEK-------VKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDD 551
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 867-1191 2.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  867 EEQSRNAE--LELDHQRSQAEQNEFLsRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSD 944
Cdd:COG1196   206 ERQAEKAEryRELKEELKELEAELLL-LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  945 VKGGETSLIIPSLERLVNAMEsknaegifdaslHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKE 1024
Cdd:COG1196   285 EAQAEEYELLAELARLEQDIA------------RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEE 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1025 TDLLRQSagsnvvykgidlpdgiapssayiinsqneyLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEY 1104
Cdd:COG1196   353 LEEAEAE------------------------------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQL 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1105 LSEkdiwKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEM 1184
Cdd:COG1196   403 EEL----EEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478


                  ....*..
gi 568967306 1185 ERHLRKE 1191
Cdd:COG1196   479 LAELLEE 485
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1930-2113 2.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1930 EKQKEITELKvrefenTKLRLQETHASEVKKVKAEVEDLRHAL-------------AQAHKDSQSLKSELQAQKEANSRa 1996
Cdd:COG4913   614 ALEAELAELE------EELAEAEERLEALEAELDALQERREALqrlaeyswdeidvASAEREIAELEAELERLDASSDD- 686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1997 ptttmrnlVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENL 2076
Cdd:COG4913   687 --------LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAA 758

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568967306 2077 LKLKEALKTSKNKENSLAD---DLNELNNELQKKQKAYNK 2113
Cdd:COG4913   759 LGDAVERELRENLEERIDAlraRLNRAEEELERAMRAFNR 798
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 2039-2250 2.83e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 43.28  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2039 ERIIAVTSQKEANLNVQqvvERHTRELKSQIEDLNENLLKLKEALKtsknkensladdlNELNNELQKKQKAYNKILRE- 2117
Cdd:PRK00409  519 NELIASLEELERELEQK---AEEAEALLKEAEKLKEELEEKKEKLQ-------------EEEDKLLEEAEKEAQQAIKEa 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2118 KDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKL----ESQLERKV-DDVDIKPVKEKSskeELIRWEE 2192
Cdd:PRK00409  583 KKEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKkkqkEKQEELKVgDEVKYLSLGQKG---EVLSIPD 659

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568967306 2193 GKKWQTKVEGLRNRLKEKEGEAHGLAKqlntlKELFAKADKEKLtlqkKLKTTGMTVD 2250
Cdd:PRK00409  660 DKEAIVQAGIMKMKVPLSDLEKIQKPK-----KKKKKKPKTVKP----KPRTVSLELD 708
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
94-284 2.99e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   94 LENELEMAQQSAGGRdTRFLRDEIRQLEKQLEQKDRELEDMEKE-----LDKEKKVNEQlalRNEEAENENSKLRRENEQ 168
Cdd:COG3206   162 LEQNLELRREEARKA-LEFLEEQLPELRKELEEAEAALEEFRQKnglvdLSEEAKLLLQ---QLSELESQLAEARAELAE 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  169 LRQDIIDYQKQIDSQKESL--LSRRGEDSDYRSQLSKKNYELVQ----YLDEIQTLTEANEKIEVQNQEMRKNLEESVQE 242
Cdd:COG3206   238 AEARLAALRAQLGSGPDALpeLLQSPVIQQLRAQLAELEAELAElsarYTPNHPDVIALRAQIAALRAQLQQEAQRILAS 317

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568967306  243 MEKmtdEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDL 284
Cdd:COG3206   318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAELRRL 356
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1901-2150 3.40e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.51  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1901 LAEMEQTVAEQDDSLSSLLTKLKKVSKDLEK-QKEITELkvrefentklrlqethASEVKKVKAEVEDLRHALAQAHKDS 1979
Cdd:COG3883     4 LALAAPTPAFADPQIQAKQKELSELQAELEAaQAELDAL----------------QAELEELNEEYNELQAELEALQAEI 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 1980 QSLKSELQAQKEAnsraptttMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVqqvve 2059
Cdd:COG3883    68 DKLQAEIAEAEAE--------IEERREELGERARALYRSGGSVSYLDVLLGSESFSDFLDRLSALSKIADADADL----- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2060 rhTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGL 2139
Cdd:COG3883   135 --LEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAA 212

                         250
                  ....*....|.
gi 568967306 2140 QSKTLIDNKQS 2150
Cdd:COG3883   213 AAAAAAAAAAA 223
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 891-1259 4.63e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   891 SRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDvkggETSLIIPSLERLVNAMESKNAE 970
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQIS----ALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   971 gIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAV-------NYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGidl 1043
Cdd:TIGR02168  752 -LSKELTELEAEIEELEERLEEAEEELAEAEAEIEeleaqieQLKEELKALREALDELRAELTLLNEEAANLRERLE--- 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1044 pdgiapSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSekdiwktdsemIREEKR 1123
Cdd:TIGR02168  828 ------SLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAS-----------LEEALA 890

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1124 KLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMErhlRKENGKHRNDVIAME 1203
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT---LEEAEALENKIEDDE 967

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568967306  1204 AEVTEKLGSLQRfkemaifKIAALQKVidNSVSLSELELANKQYNELTTKYRDILQ 1259
Cdd:TIGR02168  968 EEARRRLKRLEN-------KIKELGPV--NLAAIEEYEELKERYDFLTAQKEDLTE 1014
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 90-556 4.96e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.41  E-value: 4.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    90 KVMKLENELEMAQQSAggRDTRFLRDEIRQ----LEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENSKLRRE 165
Cdd:pfam15921  343 KIEELEKQLVLANSEL--TEARTERDQFSQesgnLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE 420

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   166 NEQLRQDIidyqkqidSQKESLLsrrgedsdyRSQLSKKNYELVQYLDEIQTLTEANEKIevqnQEMRKNLEESVQEMEK 245
Cdd:pfam15921  421 LDDRNMEV--------QRLEALL---------KAMKSECQGQMERQMAAIQGKNESLEKV----SSLTAQLESTKEMLRK 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   246 MTDEYNRMKALVHQSDavmdqikkenehyrlqvRELTDlLKAKDEEDDPVMMAVNAKVEEwkliLSSKDDEIIEYQQMLQ 325
Cdd:pfam15921  480 VVEELTAKKMTLESSE-----------------RTVSD-LTASLQEKERAIEATNAEITK----LRSRVDLKLQELQHLK 537

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   326 SLRGKLKNAQLDADksnimALKQGIQERDSQIKMLTEQVEQYTK---EMEKNTFIIEDLKNELQKDKGTSNFYQQthymk 402
Cdd:pfam15921  538 NEGDHLRNVQTECE-----ALKLQMAEKDKVIEILRQQIENMTQlvgQHGRTAGAMQVEKAQLEKEINDRRLELQ----- 607

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   403 ihsKVQILEEKTKEAERIAELAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEI- 480
Cdd:pfam15921  608 ---EFKILKDKKDAKIRELEARVSDLELEKVKLVNAgSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFr 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   481 ----------NKLEMKINDILDENEALRERA-------GLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEER 543
Cdd:pfam15921  685 nkseemetttNKLKMQLKSAQSELEQTRNTLksmegsdGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEK 764

                          490
                   ....*....|...
gi 568967306   544 LDLKRKIRQMAQE 556
Cdd:pfam15921  765 HFLKEEKNKLSQE 777
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 2016-2527 5.10e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 42.42  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2016 EKQQKALS--RALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVER-HTRE--LKSQIEDLNENLLKLKEALKTSKNKE 2090
Cdd:pfam05557   17 EKKQMELEhkRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKReAEAEeaLREQAELNRLKKKYLEALNKKLNEKE 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2091 NSLAD----------DLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSktlIDNKQSLIDELQKKVK 2160
Cdd:pfam05557   97 SQLADarevisclknELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN---LEKQQSSLAEAEQRIK 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2161 KLESQLERKVDDVDIKpvkeKSSKEELIRWEEGKKWQTKVEGLRNRLKEKEG-------EAHGLAKQLNTLKELFAKADK 2233
Cdd:pfam05557  174 ELEFEIQSQEQDSEIV----KNSKSELARIPELEKELERLREHNKHLNENIEnklllkeEVEDLKRKLEREEKYREEAAT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2234 ---EKLTLQKKLK-------TTGMTV----------------DQVLGVRALESEKELEELKKKNLDLENDILYMRtQQAL 2287
Cdd:pfam05557  250 lelEKEKLEQELQswvklaqDTGLNLrspedlsrrieqlqqrEIVLKEENSSLTSSARQLEKARRELEQELAQYL-KKIE 328

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2288 PRDSVVEDLHLQNKYLQEKLHTLEK-----KLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANK 2362
Cdd:pfam05557  329 DLNKKLKRHKALVRRLQRRVLLLTKerdgyRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEE 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2363 dlprlknQVKDLKEMCEFLKKgKLELERKLGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKkasgiltsekma 2442
Cdd:pfam05557  409 -------ELGGYKQQAQTLER-ELQALRQQESLADPSYSKEEVDSLRRKLETLELERQRLREQKNELE------------ 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2443 tIEEENRNLKAELE----KLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDK---- 2514
Cdd:pfam05557  469 -MELERRCLQGDYDpkktKVLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKevld 547

                          570
                   ....*....|...
gi 568967306  2515 MAAQLEETGKRLQ 2527
Cdd:pfam05557  548 LRKELESAELKNQ 560
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 78-183 5.34e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.35  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   78 EEQAKFEnQLKTKVMKLE---NELEMAQQSAGGRD--TRfLRDEIrqLEKQLEQKDRELEDMEKELDKEKKVNEQLALRN 152
Cdd:PRK10929  170 LAQAQLT-ALQAESAALKalvDELELAQLSANNRQelAR-LRSEL--AKKRSQQLDAYLQALRNQLNSQRQREAERALES 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568967306  153 EEAENENS-----------KLRRE-----NEQL-RQDIIDY-QKQIDSQ 183
Cdd:PRK10929  246 TELLAEQSgdlpksivaqfKINRElsqalNQQAqRMDLIASqQRQAASQ 294
PRK12704 PRK12704
phosphodiesterase; Provisional
 86-189 5.53e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   86 QLKTKVMKLENELEmaqqsaggRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKekkvneqlalRNEEAENENSKLRRE 165
Cdd:PRK12704   61 EAKEEIHKLRNEFE--------KELRERRNELQKLEKRLLQKEENLDRKLELLEK----------REEELEKKEKELEQK 122

                          90       100
                  ....*....|....*....|....
gi 568967306  166 NEQLRQDIIDYQKQIDSQKESLLS 189
Cdd:PRK12704  123 QQELEKKEEELEELIEEQLQELER 146
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 2001-2686 6.72e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.03  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2001 MRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERiiavtsqkeanlnvQQVVERHTRELKSQiEDLNENLLKLK 2080
Cdd:pfam15921   87 VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMER--------------DAMADIRRRESQSQ-EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2081 EALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGI--DQENDELRRQIKRLS-SGLQSKTLIDNKQSLIDELQK 2157
Cdd:pfam15921  152 HELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSIlvDFEEASGKKIYEHDSmSTMHFRSLGSAISKILRELDT 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2158 KVKKLESQLERKVDDVDIKPVKEKSSKEELIRWEEGK------KWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKElfaKA 2231
Cdd:pfam15921  232 EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRieqlisEHEVEITGLTEKASSARSQANSIQSQLEIIQE---QA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2232 DKEKLTLQKKLKTTGMTVDQVlgvrALESEKELEELKKKNLDLENDILYMR---TQQALPRDSVVED---LHLQNKYLQE 2305
Cdd:pfam15921  309 RNQNSMYMRQLSDLESTVSQL----RSELREAKRMYEDKIEELEKQLVLANselTEARTERDQFSQEsgnLDDQLQKLLA 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2306 KLHTLEKKLSKEKysqsltseiesddhcQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFlkkgk 2385
Cdd:pfam15921  385 DLHKREKELSLEK---------------EQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQG----- 444

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2386 lELERKLGQVRGAGRSGKTIP----ELEKTIGLMKKVVEKVQRENEQLKKASGILtSEKMATIEEENRNLKA---ELEKL 2458
Cdd:pfam15921  445 -QMERQMAAIQGKNESLEKVSsltaQLESTKEMLRKVVEELTAKKMTLESSERTV-SDLTASLQEKERAIEAtnaEITKL 522

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2459 KAHFGRQLSMQFESKNKGT--EKIVAENERLRKELKKEIEASEKLRIAKNNL-ELVNDKM----AAQLEETGKRLQFAES 2531
Cdd:pfam15921  523 RSRVDLKLQELQHLKNEGDhlRNVQTECEALKLQMAEKDKVIEILRQQIENMtQLVGQHGrtagAMQVEKAQLEKEINDR 602

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2532 RAPQLEGADSKSWKSIVVsRVYETKMKELESDIAK-------KNQSITDLKQLVREATEREQKAKKYTEDLEQQIEILK- 2603
Cdd:pfam15921  603 RLELQEFKILKDKKDAKI-RELEARVSDLELEKVKlvnagseRLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2604 NVPEGAETEQELIRELQL-LRLANNQMDKERAELI-------HQIEINKD-QTRADSSIPDSDQLKEKINDLETQLRKLE 2674
Cdd:pfam15921  682 NFRNKSEEMETTTNKLKMqLKSAQSELEQTRNTLKsmegsdgHAMKVAMGmQKQITAKRGQIDALQSKIQFLEEAMTNAN 761

                          730
                   ....*....|..
gi 568967306  2675 LEKQHSKEEVKK 2686
Cdd:pfam15921  762 KEKHFLKEEKNK 773
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 26-291 6.93e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 6.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306    26 DKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFE--NQLKTKVMKLENELEMAQQ 103
Cdd:TIGR02169  214 QALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQllEELNKKIKDLGEEEQLRVK 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   104 SAGGR---DTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQL-------ALRNEEAENENSKLRRENEQLRQDI 173
Cdd:TIGR02169  294 EKIGEleaEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELereieeeRKRRDKLTEEYAELKEELEDLRAEL 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   174 IDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRM 253
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ 453

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568967306   254 KALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEE 291
Cdd:TIGR02169  454 EWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 429-557 7.50e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.84  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  429 REKDKELVEALkrlkdYESGVYGLEDAVIEIKNckaqikirdgemEVLTKEINKLeMKINDILDENEALRERAGLEPKTM 508
Cdd:PRK05771   15 KSYKDEVLEAL-----HELGVVHIEDLKEELSN------------ERLRKLRSLL-TKLSEALDKLRSYLPKLNPLREEK 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568967306  509 IDLTEFRNSKRLKQQQYRAENqvLLKEIESLEEERLDLKRKIRQMAQER 557
Cdd:PRK05771   77 KKVSVKSLEELIKDVEEELEK--IEKEIKELEEEISELENEIKELEQEI 123
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1813-2132 8.11e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.75  E-value: 8.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1813 MKIAHQtIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEdlhvlhhkleqqadnslnkfRQTAQDLLKQspapv 1892
Cdd:pfam12128  237 MKIRPE-FTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEE--------------------RQETSAELNQ----- 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1893 ptnkhfiRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHAL 1972
Cdd:pfam12128  291 -------LLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERL 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  1973 AQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKE--- 2049
Cdd:pfam12128  364 KALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYrlk 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  2050 ---ANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQEND 2126
Cdd:pfam12128  444 srlGELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALD 523


                   ....*.
gi 568967306  2127 ELRRQI 2132
Cdd:pfam12128  524 ELELQL 529
PRK12704 PRK12704
phosphodiesterase; Provisional
 407-551 8.12e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 8.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  407 VQILEEKTKEAERIAELA---------------EADAREKDKELVEALKRLKDYESgvyGLEDAVIEIKNCKAQIKIRDG 471
Cdd:PRK12704   41 KRILEEAKKEAEAIKKEAlleakeeihklrnefEKELRERRNELQKLEKRLLQKEE---NLDRKLELLEKREEELEKKEK 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  472 EMEVLTKEINKLEMKINDILDE-NEALRERAGL---EPKTMIdltefrnskrLKQ--QQYRAENQVLLKEIEslEEERLD 545
Cdd:PRK12704  118 ELEQKQQELEKKEEELEELIEEqLQELERISGLtaeEAKEIL----------LEKveEEARHEAAVLIKEIE--EEAKEE 185


                  ....*.
gi 568967306  546 LKRKIR 551
Cdd:PRK12704  186 ADKKAK 191
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 349-633 8.55e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.59  E-value: 8.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   349 GIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKN----------------ELQKDKGTSNFYQQTHYMKIH--SKVQI- 409
Cdd:TIGR02169  164 GVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQqlerlrrerekaeryqALLKEKREYEGYELLKEKEALerQKEAIe 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   410 --LEEKTKEAERIAELAEADARE---KDKELVEALKRLKDYESGVYG-----LEDAVIEIKNCKAQIKIRDGEMEVLTKE 479
Cdd:TIGR02169  244 rqLASLEEELEKLTEEISELEKRleeIEQLLEELNKKIKDLGEEEQLrvkekIGELEAEIASLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   480 INKLEMKINDILDENEALRERAGLEPKTMIDLT-EFRNSK--------------------RLKQQQYRAENQVLLKEIES 538
Cdd:TIGR02169  324 LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeEYAELKeeledlraeleevdkefaetRDELKDYREKLEKLKREINE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306   539 LEEERLDLKRKIRQMAQERGKRNAASGLTIDDLNLSETFSHENKIEGRKLNFMSlnnmnETQSKIKSSAKTELLHRRPSF 618
Cdd:TIGR02169  404 LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKL-----EQLAADLSKYEQELYDLKEEY 478

                          330
                   ....*....|....*
gi 568967306   619 SVVQSDQSEAEENMA 633
Cdd:TIGR02169  479 DRVEKELSKLQRELA 493
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2294-2674 9.06e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2294 EDLHLQNKYLQEKLHTLEKKLskekysQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKD 2373
Cdd:COG4717    84 EEKEEEYAELQEELEELEEEL------EELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEE 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2374 LKEMCEFLKKGKLELERKLGQVRGAGRSGKtiPELEKTIGLMKKVVEKVQRENEQLKkasgiltsEKMATIEEENRNLKA 2453
Cdd:COG4717   158 LRELEEELEELEAELAELQEELEELLEQLS--LATEEELQDLAEELEELQQRLAELE--------EELEEAQEELEELEE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2454 ELEKLKAhfGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAK---------NNLELVNDKMAAQLEETGK 2524
Cdd:COG4717   228 ELEQLEN--ELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGvlflvlgllALLFLLLAREKASLGKEAE 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2525 RLQfaesRAPQLEGADSKSWKSIVvsRVYETKMKELESDIAKKNQSITDLKQLVREATEREQKAKkyTEDLEQQIEILKN 2604
Cdd:COG4717   306 ELQ----ALPALEELEEEELEELL--AALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ--LEELEQEIAALLA 377

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306 2605 vPEGAETEQELIRELQLLRLANNQMdKERAELIHQIEINKDQTRADSSIPDSDQLKEKINDLETQLRKLE 2674
Cdd:COG4717   378 -EAGVEDEEELRAALEQAEEYQELK-EELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELE 445
COG5022 COG5022
Myosin heavy chain [General function prediction only];
313-645 9.70e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.60  E-value: 9.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  313 KDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQgiQERDSQIKMLTEQVEqyTKEMEKNTFIIE------DLKNELQ 386
Cdd:COG5022   866 KETIYLQSAQRVELAERQLQELKIDVKSISSLKLVN--LELESEIIELKKSLS--SDLIENLEFKTEliarlkKLLNNID 941

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  387 KDKGTSNFYQQTHYM-KIHSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKnckaQ 465
Cdd:COG5022   942 LEEGPSIEYVKLPELnKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTK----Q 1017

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  466 IKIRDGEMEVLTKEINKlemkindILDENEALRERAGL-EPKTMIDLTEFRNSKRLKQQQYRAENQVLLKeiesleeerl 544
Cdd:COG5022  1018 LKELPVEVAELQSASKI-------ISSESTELSILKPLqKLKGLLLLENNQLQARYKALKLRRENSLLDD---------- 1080

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967306  545 dlkrkiRQMAQERGKRNAASGLTIDDLNLSETFSHENKIEGRKLNFMSLNNMNETQskIKSSAKTELLHRRPSFSVVQSD 624
Cdd:COG5022  1081 ------KQLYQLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQE--ISKFLSQLVNTLEPVFQKLSVL 1152

                         330       340
                  ....*....|....*....|.
gi 568967306  625 QSEAEENMATRSLSRMLSGIH 645
Cdd:COG5022  1153 QLELDGLFWEANLEALPSPPP 1173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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