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Conserved domains on  [gi|568962103|ref|XP_006511522|]
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F-box only protein 22 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FIST super family cl34757
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
194-260 4.36e-08

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4398:

Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 53.68  E-value: 4.36e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962103 194 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 260
Cdd:COG4398  294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
 
Name Accession Description Interval E-value
FIST COG4398
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
194-260 4.36e-08

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 53.68  E-value: 4.36e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962103 194 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 260
Cdd:COG4398  294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
FIST_C pfam10442
FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal ...
 194-260 1.44e-06

FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.


Pssm-ID: 463094  Cd Length: 135  Bit Score: 46.92  E-value: 1.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962103  194 DAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGfQYYRAKGNVEADAFRKFF-PSVPLFGFFGNGEIG 260
Cdd:pfam10442  68 DADDLIEAAERAAEAALANPPEGALLFSCAGRG-LGLGERFDEELEAIREALgDGVPLAGFYTYGEIG 134
 
Name Accession Description Interval E-value
FIST COG4398
Small ligand-binding sensory domain FIST [Signal transduction mechanisms];
194-260 4.36e-08

Small ligand-binding sensory domain FIST [Signal transduction mechanisms];


Pssm-ID: 443524 [Multi-domain]  Cd Length: 386  Bit Score: 53.68  E-value: 4.36e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962103 194 DAKTVEAAMQRL---KAANIPEQNTI--GFMFACVGRG---FQyyraKGNVEADAFRKFFPSVPLFGFFGNGEIG 260
Cdd:COG4398  294 DAQAAREDLERLlaeIREELEPGRRPrgALYFSCLGRGgglFG----EPNAELQLIREALGDIPLAGFFANGEIG 364
FIST_C pfam10442
FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal ...
 194-260 1.44e-06

FIST C domain; The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.


Pssm-ID: 463094  Cd Length: 135  Bit Score: 46.92  E-value: 1.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962103  194 DAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGfQYYRAKGNVEADAFRKFF-PSVPLFGFFGNGEIG 260
Cdd:pfam10442  68 DADDLIEAAERAAEAALANPPEGALLFSCAGRG-LGLGERFDEELEAIREALgDGVPLAGFYTYGEIG 134
FIST COG3287
FIST domain protein MJ1623, contains FIST_N and FIST_C domains [Signal transduction mechanisms] ...
 163-270 4.73e-03

FIST domain protein MJ1623, contains FIST_N and FIST_C domains [Signal transduction mechanisms];


Pssm-ID: 442517 [Multi-domain]  Cd Length: 382  Bit Score: 38.01  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962103 163 PLDIDATGvvGLSFSGHRIQSATVLLTE-DVND-AKTVEAAMQRLKAaNIPEQNTIGFMFACVGRGFqYYRAKGNVEADA 240
Cdd:COG3287  267 PLAVEEDG--SLTFAGDIPEGSVLRLMEgNPDDlIEAAERAAEAALA-RLGGKPEAALLFDCVGRRL-VLGQRVEEELEA 342

                         90       100       110
                 ....*....|....*....|....*....|
gi 568962103 241 FRKFFPsVPLFGFFGNGEIGCDRIVTGNFI 270
Cdd:COG3287  343 VSELLG-APVAGFYTYGEIGPFGGGGNQHH 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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