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Conserved domains on  [gi|568960257|ref|XP_006510760|]
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condensin-2 complex subunit D3 isoform X2 [Mus musculus]

Protein Classification

VHS/ENTH/ANTH domain-containing protein( domain architecture ID 753)

VHS (Vps27/Hrs/STAM) /ENTH (Epsin N-Terminal Homology) /ANTH (AP180 N-Terminal Homology) domain-containing protein similar to Homo sapiens ADP-ribosylation factor-binding protein GGA3 that plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VHS_ENTH_ANTH super family cl02544
VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a ...
 538-603 4.15e-04

VHS, ENTH and ANTH domain superfamily; This superfamily is composed of proteins containing a VHS, CID, ENTH, or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal Transducing Adaptor Molecule). It is located at the N-termini of proteins involved in intracellular membrane trafficking. The CTD-Interacting Domain (CID) is present in several RNA-processing factors and binds tightly to the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP II or Pol II). The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet unique module referred to as an AP180 N-Terminal Homology (ANTH) domain. VHS, ENTH, and ANTH domains are structurally similar and are composed of a superhelix of eight alpha helices. ENTH and ANTH (E/ANTH) domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH domain-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the Trans-Golgi Network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding.


The actual alignment was detected with superfamily member pfam01417:

Pssm-ID: 470608  Cd Length: 124  Bit Score: 41.78  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 568960257   603 M 603
Cdd:pfam01417  119 E 119
Cnd1 super family cl38367
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 913-1070 7.09e-03

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


The actual alignment was detected with superfamily member pfam12717:

Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 38.98  E-value: 7.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   913 VIRAHAIITLGklCLQHEDLAKKSIPAL----------VRE---------LEEEYVKWKGsLFFRFVSTLVDSHPDIASL 973
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLyrrlkdedpyVRKtaamcvaklILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   974 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1050
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 568960257  1051 -FNVTSKICLNILACFTDGIL 1070
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
 
Name Accession Description Interval E-value
ENTH pfam01417
ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in ...
 538-603 4.15e-04

ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.


Pssm-ID: 426255  Cd Length: 124  Bit Score: 41.78  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 568960257   603 M 603
Cdd:pfam01417  119 E 119
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 913-1070 7.09e-03

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 38.98  E-value: 7.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   913 VIRAHAIITLGklCLQHEDLAKKSIPAL----------VRE---------LEEEYVKWKGsLFFRFVSTLVDSHPDIASL 973
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLyrrlkdedpyVRKtaamcvaklILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   974 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1050
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 568960257  1051 -FNVTSKICLNILACFTDGIL 1070
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
 
Name Accession Description Interval E-value
ENTH pfam01417
ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in ...
 538-603 4.15e-04

ENTH domain; The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery. The function of the ENTH domain is unknown.


Pssm-ID: 426255  Cd Length: 124  Bit Score: 41.78  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   538 MTMLRKRIKDEKINVR---KsALQVLMSILK------------HCDILSMEQDLLILQDHCRDPAISVRKQAlQSLTELV 602
Cdd:pfam01417   41 MKMLWKRLNDKGKNWRhiyK-ALTLLEYLLKngservvddlreNIYIIRTLTDFHYIDENGKDQGINVRKKA-KEILNLL 118


                   .
gi 568960257   603 M 603
Cdd:pfam01417  119 E 119
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
 913-1070 7.09e-03

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 38.98  E-value: 7.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   913 VIRAHAIITLGklCLQHEDLAKKSIPAL----------VRE---------LEEEYVKWKGsLFFRFVSTLVDSHPDIASL 973
Cdd:pfam12717    1 LIRALAIRTMG--CIRFPNLVEYLTEPLyrrlkdedpyVRKtaamcvaklILPDMVKVKG-FISELAKLLEDPNPMVVAN 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960257   974 gefCLAHL--LLKRNPTMFFQHFIECIFHFNSyekhgqynkfsqsergkqlflLKGKTNKEKRMRIYKFLLEHFTDEQR- 1050
Cdd:pfam12717   78 ---ALAALteISEKDPNAIYNLLPDIISKLSD---------------------ALNECSEWGQIYILDFLASYIPKDKQe 133

                          170       180
                   ....*....|....*....|.
gi 568960257  1051 -FNVTSKICLNILACFTDGIL 1070
Cdd:pfam12717  134 aESLVEKLCPRLQHANSAVVL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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