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Conserved domains on  [gi|568960046|ref|XP_006510658|]
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beta-galactosidase-1-like protein 3 isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AmyAc_family super family cl38930
Alpha amylase catalytic domain family; The Alpha-amylase family comprises the largest family ...
1-53 8.24e-19

Alpha amylase catalytic domain family; The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; and C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost this catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.


The actual alignment was detected with superfamily member pfam01301:

Pssm-ID: 476817 [Multi-domain]  Cd Length: 316  Bit Score: 85.39  E-value: 8.24e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568960046    1 MYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 53
Cdd:pfam01301 267 LYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PRK10531 super family cl30603
putative acyl-CoA thioester hydrolase;
255-286 3.65e-03

putative acyl-CoA thioester hydrolase;


The actual alignment was detected with superfamily member PRK10531:

Pssm-ID: 236709 [Multi-domain]  Cd Length: 422  Bit Score: 39.00  E-value: 3.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568960046 255 LPNWHYGFVFINGR---------NLGRYWDIGPQRTLYLPG 286
Cdd:PRK10531 319 LPNIYYGFLAINSRfnasgdgvaQLGRAWDVDAGLSAYVNG 359
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
1-53 8.24e-19

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 85.39  E-value: 8.24e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568960046    1 MYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 53
Cdd:pfam01301 267 LYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
2-51 2.74e-06

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 49.23  E-value: 2.74e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568960046   2 YMFHGGTNFGFINGGRYenhhisVVTSYDYDAVLSEAGDYTE-KYFKLRKL 51
Cdd:PLN03059 294 YMYHGGTNFGRTAGGPF------IATSYDYDAPLDEYGLPREpKWGHLRDL 338
PRK10531 PRK10531
putative acyl-CoA thioester hydrolase;
255-286 3.65e-03

putative acyl-CoA thioester hydrolase;


Pssm-ID: 236709 [Multi-domain]  Cd Length: 422  Bit Score: 39.00  E-value: 3.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568960046 255 LPNWHYGFVFINGR---------NLGRYWDIGPQRTLYLPG 286
Cdd:PRK10531 319 LPNIYYGFLAINSRfnasgdgvaQLGRAWDVDAGLSAYVNG 359
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
26-53 5.95e-03

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 38.37  E-value: 5.95e-03
                         10        20
                 ....*....|....*....|....*...
gi 568960046  26 VTSYDYDAVLSEAGDYTEKYFKLRKLFA 53
Cdd:COG1874  349 GTEYDHDAPLDHAGRPTRKFREVRELGA 376
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
1-53 8.24e-19

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 85.39  E-value: 8.24e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568960046    1 MYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 53
Cdd:pfam01301 267 LYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
2-51 2.74e-06

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 49.23  E-value: 2.74e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568960046   2 YMFHGGTNFGFINGGRYenhhisVVTSYDYDAVLSEAGDYTE-KYFKLRKL 51
Cdd:PLN03059 294 YMYHGGTNFGRTAGGPF------IATSYDYDAPLDEYGLPREpKWGHLRDL 338
PRK10531 PRK10531
putative acyl-CoA thioester hydrolase;
255-286 3.65e-03

putative acyl-CoA thioester hydrolase;


Pssm-ID: 236709 [Multi-domain]  Cd Length: 422  Bit Score: 39.00  E-value: 3.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568960046 255 LPNWHYGFVFINGR---------NLGRYWDIGPQRTLYLPG 286
Cdd:PRK10531 319 LPNIYYGFLAINSRfnasgdgvaQLGRAWDVDAGLSAYVNG 359
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
26-53 5.95e-03

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 38.37  E-value: 5.95e-03
                         10        20
                 ....*....|....*....|....*...
gi 568960046  26 VTSYDYDAVLSEAGDYTEKYFKLRKLFA 53
Cdd:COG1874  349 GTEYDHDAPLDHAGRPTRKFREVRELGA 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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