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Conserved domains on  [gi|568959438|ref|XP_006510363|]
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beta-galactosidase-1-like protein 2 isoform X2 [Mus musculus]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
60-373 4.26e-158

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 456.72  E-value: 4.26e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438   60 DFILEDSIFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIQLAAKIGLWVI 139
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  140 LRPGPYICSEIDLGGLPSWLLQDPDMKLRTTYHGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNKDRAYM 219
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  220 PYIKKALEDRGIIE-MLLTSD--NKDGLEKGVVDG--VLATINLQSQQELMALNTVLLSIQGIQPKMVMEYWTGWFDSWG 294
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568959438  295 GSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFNDykaDVTSYDYDAILTEAGDYTAKYTKLRELFG 373
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYGP---QTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
60-373 4.26e-158

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 456.72  E-value: 4.26e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438   60 DFILEDSIFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIQLAAKIGLWVI 139
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  140 LRPGPYICSEIDLGGLPSWLLQDPDMKLRTTYHGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNKDRAYM 219
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  220 PYIKKALEDRGIIE-MLLTSD--NKDGLEKGVVDG--VLATINLQSQQELMALNTVLLSIQGIQPKMVMEYWTGWFDSWG 294
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568959438  295 GSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFNDykaDVTSYDYDAILTEAGDYTAKYTKLRELFG 373
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYGP---QTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
68-501 4.21e-54

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 195.15  E-value: 4.21e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  68 FQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTT-YVPWNLHEPERGKFDFSGnldLEAFIQLAAKIGLWVILRPGPYI 146
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 147 cseidlggLPSWLLQD-PDMkLRTTYHG-----------------FTKAVDLYFDHLMSRvvplqYKHGGPIIAVQVENE 208
Cdd:COG1874   86 --------PPAWLLKKyPEI-LPVDADGrrrgfgsrrhycpsspvYREAARRIVRALAER-----YGDHPAVIMWQVDNE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 209 YGSYNkdraYMPYIKKA----LEDR-GIIEML---------------------------------------LTSD----- 239
Cdd:COG1874  152 YGSYD----YCDACAAAfrdwLRERyGTLDALneawgtafwsqrytdwdeiepprltpttanpslrldfrrFSSDqvley 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 240 ---NKDGLEKGVVD-----------------------GVLATIN----LQSQQELMALNTVLL-SIQGIQPKMVMEYWTG 288
Cdd:COG1874  228 lraQRDILREAGPDvpvttnfmgpfpgldywklardlDVVSWDNypdgSAADPDEIAFAHDLMrGLKGGGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 289 WFdSWGGSHNILDSSEV-LQTVSAIIKDGSSINLYMFHggtnfgfingAMHFndykadVTSYDYDAILTEAGDYTAKYTK 367
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLrLWSLQALAHGADGVNYFQWR----------PSRG------GTEYDHDAPLDHAGRPTRKFRE 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 368 LRELFGTVSGIPPPPPPELTAK--MVYEpmspalYLSLWdAIQYMDKPvtsetpinmenlpvnngNGQAFGYV-----LY 440
Cdd:COG1874  371 VRELGAELARLPEVPGSRVTARvaLLFD------WESWW-ALEIQSPP-----------------LGQDLGYVdlvraLY 426
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568959438 441 ETtifssgvlsgLVRDRGQVFLNRVSIGFLDYKTtkITIP---LTQGYTILRIL--VENRGRVNYG 501
Cdd:COG1874  427 RA----------LRRAGVTVDIVPPFADLSGYKL--LVAPalyLVSDALAERLLayVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
70-371 4.02e-46

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 175.19  E-value: 4.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  70 ILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIQLAAKIGLWVILRPGPYICSE 149
Cdd:PLN03059  46 LISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHLRIGPYICAE 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 150 IDLGGLPSWLLQDPDMKLRTTYHGFTKAVDLYFDHL--MSRVVPLQYKHGGPIIAVQVENEYG--SYNKDRAYMPYIKKA 225
Cdd:PLN03059 126 WNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIvdMMKSEKLFEPQGGPIILSQIENEYGpvEWEIGAPGKAYTKWA 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 226 LE-----DRGIIEMLLTSDNKDglekgvvDGVLATINlQSQQELMALNtvllsiQGIQPKMVMEYWTGWFDSWGGSHNIL 300
Cdd:PLN03059 206 ADmavklGTGVPWVMCKQEDAP-------DPVIDTCN-GFYCENFKPN------KDYKPKMWTEAWTGWYTEFGGAVPNR 271
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568959438 301 DSSEVLQTVSAIIKDGSS-INLYMFHGGTNFGFINGAMHFndykadVTSYDYDAILTEAG-DYTAKYTKLREL 371
Cdd:PLN03059 272 PAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAGGPFI------ATSYDYDAPLDEYGlPREPKWGHLRDL 338
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
60-373 4.26e-158

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 456.72  E-value: 4.26e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438   60 DFILEDSIFQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIQLAAKIGLWVI 139
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  140 LRPGPYICSEIDLGGLPSWLLQDPDMKLRTTYHGFTKAVDLYFDHLMSRVVPLQYKHGGPIIAVQVENEYGSYNKDRAYM 219
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  220 PYIKKALEDRGIIE-MLLTSD--NKDGLEKGVVDG--VLATINLQSQQELMALNTVLLSIQGIQPKMVMEYWTGWFDSWG 294
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568959438  295 GSHNILDSSEVLQTVSAIIKDGSSINLYMFHGGTNFGFINGAMHFNDykaDVTSYDYDAILTEAGDYTAKYTKLRELFG 373
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYGP---QTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
68-501 4.21e-54

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 195.15  E-value: 4.21e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  68 FQILGGSIHYFRVPREYWRDRLLKLKACGLNTLTT-YVPWNLHEPERGKFDFSGnldLEAFIQLAAKIGLWVILRPGPYI 146
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 147 cseidlggLPSWLLQD-PDMkLRTTYHG-----------------FTKAVDLYFDHLMSRvvplqYKHGGPIIAVQVENE 208
Cdd:COG1874   86 --------PPAWLLKKyPEI-LPVDADGrrrgfgsrrhycpsspvYREAARRIVRALAER-----YGDHPAVIMWQVDNE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 209 YGSYNkdraYMPYIKKA----LEDR-GIIEML---------------------------------------LTSD----- 239
Cdd:COG1874  152 YGSYD----YCDACAAAfrdwLRERyGTLDALneawgtafwsqrytdwdeiepprltpttanpslrldfrrFSSDqvley 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 240 ---NKDGLEKGVVD-----------------------GVLATIN----LQSQQELMALNTVLL-SIQGIQPKMVMEYWTG 288
Cdd:COG1874  228 lraQRDILREAGPDvpvttnfmgpfpgldywklardlDVVSWDNypdgSAADPDEIAFAHDLMrGLKGGGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 289 WFdSWGGSHNILDSSEV-LQTVSAIIKDGSSINLYMFHggtnfgfingAMHFndykadVTSYDYDAILTEAGDYTAKYTK 367
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLrLWSLQALAHGADGVNYFQWR----------PSRG------GTEYDHDAPLDHAGRPTRKFRE 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 368 LRELFGTVSGIPPPPPPELTAK--MVYEpmspalYLSLWdAIQYMDKPvtsetpinmenlpvnngNGQAFGYV-----LY 440
Cdd:COG1874  371 VRELGAELARLPEVPGSRVTARvaLLFD------WESWW-ALEIQSPP-----------------LGQDLGYVdlvraLY 426
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568959438 441 ETtifssgvlsgLVRDRGQVFLNRVSIGFLDYKTtkITIP---LTQGYTILRIL--VENRGRVNYG 501
Cdd:COG1874  427 RA----------LRRAGVTVDIVPPFADLSGYKL--LVAPalyLVSDALAERLLayVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
70-371 4.02e-46

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 175.19  E-value: 4.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  70 ILGGSIHYFRVPREYWRDRLLKLKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFIQLAAKIGLWVILRPGPYICSE 149
Cdd:PLN03059  46 LISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHLRIGPYICAE 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 150 IDLGGLPSWLLQDPDMKLRTTYHGFTKAVDLYFDHL--MSRVVPLQYKHGGPIIAVQVENEYG--SYNKDRAYMPYIKKA 225
Cdd:PLN03059 126 WNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIvdMMKSEKLFEPQGGPIILSQIENEYGpvEWEIGAPGKAYTKWA 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438 226 LE-----DRGIIEMLLTSDNKDglekgvvDGVLATINlQSQQELMALNtvllsiQGIQPKMVMEYWTGWFDSWGGSHNIL 300
Cdd:PLN03059 206 ADmavklGTGVPWVMCKQEDAP-------DPVIDTCN-GFYCENFKPN------KDYKPKMWTEAWTGWYTEFGGAVPNR 271
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568959438 301 DSSEVLQTVSAIIKDGSS-INLYMFHGGTNFGFINGAMHFndykadVTSYDYDAILTEAG-DYTAKYTKLREL 371
Cdd:PLN03059 272 PAEDLAFSVARFIQNGGSfINYYMYHGGTNFGRTAGGPFI------ATSYDYDAPLDEYGlPREPKWGHLRDL 338
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
78-235 1.27e-14

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 75.77  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438   78 FRVPREYWRDRLLKLKACGLNTLT-TYVPWNLHEPERGKFDFSGnldLEAFIQLAAKIGLWVILRPGPyicseidlGGLP 156
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRiGIFAWAKLEPEEGKYDFEW---LDEVIDLLAKAGIKVILATPT--------AAPP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959438  157 SWLLQD-PDMkLRTT----------YHGFTKAVDLYFDHLMsRVVPL---QYKHGGPIIAVQVENEYGSYNkDRAYMPYI 222
Cdd:pfam02449  74 AWLVKKhPEI-LPVDadgrrrgfgsRHHYCPSSPVYREYAA-RIVEAlaeRYGDHPALIGWHIDNEYGCHV-SECYCETC 150
                         170
                  ....*....|....*...
gi 568959438  223 KKA----LEDR-GIIEML 235
Cdd:pfam02449 151 ERAfrkwLKNRyGTIDAL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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