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Conserved domains on  [gi|568953551|ref|XP_006508971|]
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volume-regulated anion channel subunit LRRC8E isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-396 8.12e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 133 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 212
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 213 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 292
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 293 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 372
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 568953551 373 RLELKGNRLETLPeELGDCKGLKK 396
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-396 8.12e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 133 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 212
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 213 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 292
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 293 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 372
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 568953551 373 RLELKGNRLETLPeELGDCKGLKK 396
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
210-388 9.15e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.36  E-value: 9.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 210 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 270
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 271 EHVRKlrSLEQLYLSHNKLETLPTQLGQcfGLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 350
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568953551 351 LLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEEL 388
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 231-379 3.75e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 3.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 231 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpTQLGQCFGLRLLDLSHN 310
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 311 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLT---QLSPDVAALQALSRLELK 377
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 568953551 378 GN 379
Cdd:cd21340  177 GN 178
LRR_8 pfam13855
Leucine rich repeat;
301-358 1.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.78e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  301 GLRLLDLSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 358
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-396 8.12e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 133 LEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELE 212
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 213 LVACGLerIPHAIFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETL 292
Cdd:COG4886   82 LSLLLL--GLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 293 PTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALS 372
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLE 231

                        250       260
                 ....*....|....*....|....
gi 568953551 373 RLELKGNRLETLPeELGDCKGLKK 396
Cdd:COG4886  232 TLDLSNNQLTDLP-ELGNLTNLEE 254
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
210-388 9.15e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.36  E-value: 9.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 210 ELELVACGLERIPHAI--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 270
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 271 EHVRKlrSLEQLYLSHNKLETLPTQLGQcfGLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDELffCHKLRT 350
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568953551 351 LLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEEL 388
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 231-379 3.75e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 3.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 231 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSHNKLETLpTQLGQCFGLRLLDLSHN 310
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 311 glrSLPPE----------LGLLQSLQHLALSYNALESLpDELFFCHKLRTLLLGYNHLT---QLSPDVAALQALSRLELK 377
Cdd:cd21340  101 ---RLPPGekltfdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 568953551 378 GN 379
Cdd:cd21340  177 GN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-394 2.40e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 2.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  75 SFPPGLSQLVNLQELSLLHSPARLPFSSQIFlrDRLKVICVKFEELR---EVPLWVFGLRGLEELHLeglFPPEMArGAT 151
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSlsgEIPELVIQLQNLEILHL---FSNNFT-GKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 152 LESLRELKQLKVLSLRSN--AGKVPASvtdvaghlqrLSLHNDGARL-LALNSLKKlavlrelelvacgleRIPHAIFSL 228
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNkfSGEIPKN----------LGKHNNLTVLdLSTNNLTG---------------EIPEGLCSS 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 229 GALQELDLKDNHLRSiEEILSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE--------TLPT----- 294
Cdd:PLN00113 380 GNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPSlqmls 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 295 --------QLGQCFG---LRLLDLSHNGLR-SLPPELGLLQSLQHLALSYNALES-LPDELFFCHKLRTLLLGYNHLT-Q 360
Cdd:PLN00113 459 larnkffgGLPDSFGskrLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQ 538

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 568953551 361 LSPDVAALQALSRLELKGNRLE-TLPEELGDCKGL 394
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-390 6.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 6.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  73 DISFPPGLSQLVNLQELSLLHSparlpfssqiflrdrlkvicvkfeELREVPLWVFGLRGLEELHLEG----LFPpemar 148
Cdd:COG4886  102 DLSGNEELSNLTNLESLDLSGN------------------------QLTDLPEELANLTNLKELDLSNnqltDLP----- 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 149 gatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDGARLLAlNSLKKLAVLRELELVACGLERIPHAIFS 227
Cdd:COG4886  153 ----EPLGNLTNLKSLDLSNNQlTDLPEELGNLT-NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLAN 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 228 LGALQELDLKDNHLRSIEEILSFQhcrKLVTLRLWHNQIAYVPEhVRKLRSLEQLYLSHNKLETLPTQLGQCFGLRLLDL 307
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 308 SHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALSRLELKGNRLETLPEE 387
Cdd:COG4886  303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382


                 ...
gi 568953551 388 LGD 390
Cdd:COG4886  383 ALL 385
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-381 2.68e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  37 RNMRGRLELSLCMLP--------------GLPDTVFELSEveALRLEAICDISFPPGLSQ--LVNLQELSLLHSPARLPF 100
Cdd:PLN00113  79 KNISGKISSAIFRLPyiqtinlsnnqlsgPIPDDIFTTSS--SLRYLNLSNNNFTGSIPRgsIPNLETLDLSNNMLSGEI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 101 SSQIFLRDRLKVICVKFEELR-EVPLWVFGLRGLEEL-----HLEGLFPPEMARgatleslreLKQLKVLSLRSN--AGK 172
Cdd:PLN00113 157 PNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLtlasnQLVGQIPRELGQ---------MKSLKWIYLGYNnlSGE 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 173 VPASVTDVAG--HLQRLSLHNDGARLLALNSLKKLAVLRELELVACGleRIPHAIFSLGALQELDLKDNHLR-SIEEILS 249
Cdd:PLN00113 228 IPYEIGGLTSlnHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG--PIPPSIFSLQKLISLDLSDNSLSgEIPELVI 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 250 fqHCRKLVTLRLWHNQI-AYVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLDLSHNGLRSLPPElGLLQS--L 325
Cdd:PLN00113 306 --QLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPE-GLCSSgnL 382

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568953551 326 QHLALSYNALES-LPDELFFCHKLRTLLLGYNHLT-QLSPDVAALQALSRLELKGNRL 381
Cdd:PLN00113 383 FKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
255-414 9.82e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 9.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 255 KLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSHNKLETLPTQLGQCfgLRLLDLSHNGLRSLPPELGllQSLQHLALSYNA 334
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPDT--IQEMELSINRITELPERLP--SALQSLDLFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 335 LESLPDELffCHKLRTLLLGYNHLTQLSPDVAAlqALSRLELKGNRLETLPEELGdcKGLKksgLLVED-----TLYEGL 409
Cdd:PRK15370 274 ISCLPENL--PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLK---TLEAGenaltSLPASL 344


                 ....*
gi 568953551 410 PAEVR 414
Cdd:PRK15370 345 PPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 161-396 1.32e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 161 LKVLSLRSNA--GKVPASVTDVAGhLQRLSLhndgarllALNSL-----KKLAVLRELELVACGLE----RIPHAIFSLG 229
Cdd:PLN00113 166 LKVLDLGGNVlvGKIPNSLTNLTS-LEFLTL--------ASNQLvgqipRELGQMKSLKWIYLGYNnlsgEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 230 ALQELDLKDNHLrSIEEILSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLDL 307
Cdd:PLN00113 237 SLNHLDLVYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 308 SHNGLR-SLPPELGLLQSLQHLALSYNALE-SLPDELFFCHKLRTLLLGYNHLTQLSPD-VAALQALSRLELKGNRLET- 383
Cdd:PLN00113 316 FSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKLILFSNSLEGe 395

                        250
                 ....*....|...
gi 568953551 384 LPEELGDCKGLKK 396
Cdd:PLN00113 396 IPKSLGACRSLRR 408
PLN03150 PLN03150
hypothetical protein; Provisional
 268-335 9.54e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.05  E-value: 9.54e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 268 YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLGQCFGLRLLDLSHNGLR-SLPPELGLLQSLQHLALSYNAL 335
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 221-317 4.04e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 221 IPHAIFSLGALQELDLKDNHLRS-IEEILSfqHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPTQLG 297
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGeIPDELS--SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                         90       100
                 ....*....|....*....|.
gi 568953551 298 QCFGLRLLDLSHNGLR-SLPP 317
Cdd:PLN00113 569 NVESLVQVNISHNHLHgSLPS 589
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
152-342 7.12e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 7.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 152 LESLRELKQ--LKVLSLRSNA-GKVPASVTDVAGHLQrlslhndgarlLALNSLKKL-----AVLRELELVACGLERIPH 223
Cdd:PRK15370 211 LKSLPENLQgnIKTLYANSNQlTSIPATLPDTIQEME-----------LSINRITELperlpSALQSLDLFHNKISCLPE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 224 AIFSlgALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVPEHV-RKLRSLEQ------------------LYL 284
Cdd:PRK15370 280 NLPE--ELRYLSVYDNSIRTLPAHLP----SGITHLNVQSNSLTALPETLpPGLKTLEAgenaltslpaslppelqvLDV 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568953551 285 SHNKLETLPTQLGQCfgLRLLDLSHNGLRSLPPELGllQSLQHLALSYNALESLPDEL 342
Cdd:PRK15370 354 SKNQITVLPETLPPT--ITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
301-358 1.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.78e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  301 GLRLLDLSHNGLRSLPPELGL-LQSLQHLALSYNALESLPDELFFC-HKLRTLLLGYNHL 358
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 104-381 2.04e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 104 IFLRDRLKVICVKFEELREVPLWvfglrglEELHLEGLFPPEMAR--GATLESLRELKQLKVLSLRSNAGKVPASVTDVa 181
Cdd:COG5238   84 AFPTQLLVVDWEGAEEVSPVALA-------ETATAVATPPPDLRRimAKTLEDSLILYLALPRRINLIQVLKDPLGGNA- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 182 ghlQRLSLHNDGARLLALNSLKKLAVLRELELVAC--------GLERIPHAIFSLGALQELDLKDNHL--RSIEEILS-F 250
Cdd:COG5238  156 ---VHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnqigdeGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaL 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 251 QHCRKLVTLRLWHNQI-----AYVPEHVRKLRSLEQLYLSHNKL-----ETLPTQLGQCFGLRLLDLSHNGLRSlPPELG 320
Cdd:COG5238  233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGD-EGAIA 311

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568953551 321 LLQSLQHlalsynaleslpdelffCHKLRTLLLGYNhltQLSPD-----VAALQA---LSRLELKGNRL 381
Cdd:COG5238  312 LAEGLQG-----------------NKTLHTLNLAYN---GIGAQgaialAKALQEnttLHSLDLSDNQI 360
LRR_8 pfam13855
Leucine rich repeat;
323-381 5.41e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568953551  323 QSLQHLALSYNALESLPDELFF-CHKLRTLLLGYNHLTQLSPDV-AALQALSRLELKGNRL 381
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
254-312 6.98e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568953551  254 RKLVTLRLWHNQIAYVPEHV-RKLRSLEQLYLSHNKLETLPTQLGQCF-GLRLLDLSHNGL 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
208-266 6.13e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 6.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551  208 LRELELVACGLERI-PHAIFSLGALQELDLKDNHLRSIEEIlSFQHCRKLVTLRLWHNQI 266
Cdd:pfam13855   3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
208-398 1.83e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.53  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 208 LRELELVACGLERIPhaIFSLGALqELDLKDNHLRSIEEILSfqhcrKLVTLRLWHNQIAYVPEHVRklrSLEQLYLSHN 287
Cdd:PRK15387 244 LRTLEVSGNQLTSLP--VLPPGLL-ELSIFSNPLTHLPALPS-----GLCKLWIFGNQLTSLPVLPP---GLQELSVSDN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 288 KLETLPTQLGQcfgLRLLDLSHNGLRSLPPelgLLQSLQHLALSYNALESLPDelfFCHKLRTLLLGYNHLTQLSpdvAA 367
Cdd:PRK15387 313 QLASLPALPSE---LCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPT---LPSELYKLWAYNNRLTSLP---AL 380

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568953551 368 LQALSRLELKGNRLETLPEELGDCKGLKKSG 398
Cdd:PRK15387 381 PSGLKELIVSGNRLTSLPVLPSELKELMVSG 411
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
256-385 4.97e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.38  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 256 LVTLRLWHNQIAYVPEHVRKLRsleQLYLSHNKLETLPTQLGqcfGLRLLDLSHNGLRSLPPelgLLQSLQHLALSYNAL 335
Cdd:PRK15387 304 LQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLPTLPS---GLQELSVSDNQLASLPT---LPSELYKLWAYNNRL 374

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568953551 336 ESLPDelfFCHKLRTLLLGYNHLTQLsPDVAAlqALSRLELKGNRLETLP 385
Cdd:PRK15387 375 TSLPA---LPSGLKELIVSGNRLTSL-PVLPS--ELKELMVSGNRLTSLP 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 157-294 5.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953551 157 ELKQLKVLSLRSNA--GKVPASVTdvAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLE-RIPHAIFSLGALQE 233
Cdd:PLN00113 450 DMPSLQMLSLARNKffGGLPDSFG--SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVS 527

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568953551 234 LDLKDNHLrSIEEILSFQHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSHNKLE-TLPT 294
Cdd:PLN00113 528 LDLSHNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPS 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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