NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568943289|ref|XP_006506874|]
View 

ATP-dependent RNA helicase DQX1 isoform X3 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 1-116 1.67e-54

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd17986:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 177  Bit Score: 183.18  E-value: 1.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17986   64 RSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKD 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TRLRNlpGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17986  144 VRLQR--PELRVVVVTSPALEPKLRAFWGNPPVVHV 177
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
2-510 3.19e-48

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 180.66  E-value: 3.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:COG1643   70 AAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  82 R------LRnlpgdprvVVVT----DPAlepKFQAFWGNSPIVRV------------PREPGGDptlaykdtvptDLVEA 139
Cdd:COG1643  150 QpalrpdLK--------LLVMsatlDAE---RFARLLGDAPVIESsgrtypvevryrPLPADER-----------DLEDA 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 140 ACQAVLELCQQEeaPGDVLVYLPSEEEISLCCESLSGEMgtlavpGPPPRVLPLH---PGCAQ--AIQTVYEDTdvsvRK 214
Cdd:COG1643  208 VADAVREALAEE--PGDILVFLPGEREIRRTAEALRGRL------PPDTEILPLYgrlSAAEQdrAFAPAPHGR----RR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 215 IVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTlELEAPP 294
Cdd:COG1643  276 IVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEED-FARRPA 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 295 LPHPKVCEENLSSLVLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALL 374
Cdd:COG1643  355 FTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLL 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 375 ASCEFNCVDEMLTLAAMLTAapgftRPPL-SAGEAALRRALEHADGDHSSLiqvyEAFVQSGADEAWCQarglnweslcQ 453
Cdd:COG1643  435 AAAELGCLREAAILAALLSE-----RDPRrGAAGSDLLARLNLWRRLREQQ----REFLSYLRLREWRD----------L 495

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568943289 454 ARKLRAElvelmqrielpLSQPAFGSEQNRRDLQKALLSGYFLKVARDTDGTGNYLL 510
Cdd:COG1643  496 ARQLRRL-----------LGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYLL 541
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 486-569 2.55e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.60  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  486 LQKALLSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCSyrNRRTPAQPPTWVLYHSFSISKDNCLCIVSEIQPEMLVEL 565
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSV--LFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLF 78


                  ....
gi 568943289  566 APPY 569
Cdd:pfam07717  79 APHI 82
 
Name Accession Description Interval E-value
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-116 1.67e-54

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 183.18  E-value: 1.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17986   64 RSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKD 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TRLRNlpGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17986  144 VRLQR--PELRVVVVTSPALEPKLRAFWGNPPVVHV 177
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
2-510 3.19e-48

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 180.66  E-value: 3.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:COG1643   70 AAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  82 R------LRnlpgdprvVVVT----DPAlepKFQAFWGNSPIVRV------------PREPGGDptlaykdtvptDLVEA 139
Cdd:COG1643  150 QpalrpdLK--------LLVMsatlDAE---RFARLLGDAPVIESsgrtypvevryrPLPADER-----------DLEDA 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 140 ACQAVLELCQQEeaPGDVLVYLPSEEEISLCCESLSGEMgtlavpGPPPRVLPLH---PGCAQ--AIQTVYEDTdvsvRK 214
Cdd:COG1643  208 VADAVREALAEE--PGDILVFLPGEREIRRTAEALRGRL------PPDTEILPLYgrlSAAEQdrAFAPAPHGR----RR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 215 IVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTlELEAPP 294
Cdd:COG1643  276 IVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEED-FARRPA 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 295 LPHPKVCEENLSSLVLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALL 374
Cdd:COG1643  355 FTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLL 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 375 ASCEFNCVDEMLTLAAMLTAapgftRPPL-SAGEAALRRALEHADGDHSSLiqvyEAFVQSGADEAWCQarglnweslcQ 453
Cdd:COG1643  435 AAAELGCLREAAILAALLSE-----RDPRrGAAGSDLLARLNLWRRLREQQ----REFLSYLRLREWRD----------L 495

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568943289 454 ARKLRAElvelmqrielpLSQPAFGSEQNRRDLQKALLSGYFLKVARDTDGTGNYLL 510
Cdd:COG1643  496 ARQLRRL-----------LGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYLL 541
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 132-283 1.43e-44

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 156.15  E-value: 1.43e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 132 VPTDLVEAACQAVLELCQQEEaPGDVLVYLPSEEEISLCCESLSGEMGTLavPGPPPRVLPLHPGCAQAIQT-VYEDTDV 210
Cdd:cd18791   22 EDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREELLSP--DLGKLLVLPLHSSLPPEEQQrVFEPPPP 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568943289 211 SVRKIVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLY 283
Cdd:cd18791   99 GVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 2-566 2.47e-37

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 149.05  E-value: 2.47e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289    2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:PRK11131  133 TVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKEL 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   82 rlrnLPGDPRV-VVVTDPALEP-KFQAFWGNSPIVRV-----PREPGGDPTLAYKDTVPTDLVEAACQAVLELCqqEEAP 154
Cdd:PRK11131  213 ----LPRRPDLkVIITSATIDPeRFSRHFNNAPIIEVsgrtyPVEVRYRPIVEEADDTERDQLQAIFDAVDELG--REGP 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  155 GDVLVYLPSEEEISLCCESLSGEmgTLavpgPPPRVLPLHPGCAQAIQT-VYEDTdvSVRKIVVTHWLADFSFSLPSIQH 233
Cdd:PRK11131  287 GDILIFMSGEREIRDTADALNKL--NL----RHTEILPLYARLSNSEQNrVFQSH--SGRRIVLATNVAETSLTVPGIKY 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  234 VIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLeLEAPPLPHPKVCEENLSSLVLLLM 313
Cdd:PRK11131  359 VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDF-LSRPEFTDPEILRTNLASVILQMT 437

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  314 RKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDG-----ELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTL 388
Cdd:PRK11131  438 ALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  389 AAMLTAAPGFTRP---PLSAGEAalRRALEHADGDHSSLIQVYEaFVQSGADE-------AWCQARGLNWESLCQARKLR 458
Cdd:PRK11131  518 TSALSIQDPRERPmdkQQASDEK--HRRFADKESDFLAFVNLWN-YLQEQQKAlssnqfrRLCRTDYLNYLRVREWQDIY 594

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  459 AELVELMQRIELPL-SQPAfgseqNRRDLQKALLSGyflkvardtdgtgnylLLTH--KHVAQLSPYCSYRNRR---TPA 532
Cdd:PRK11131  595 TQLRQVVKELGIPVnSEPA-----EYREIHTALLTG----------------LLSHigMKDAEKQEYTGARNARfsiFPG 653

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 568943289  533 -----QPPTWVLYHSFSISKDNCLCIVSEIQPEMLVELA 566
Cdd:PRK11131  654 sglfkKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLA 692
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 337-417 3.08e-21

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 88.83  E-value: 3.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  337 ALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAALRRALEH 416
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80


                  .
gi 568943289  417 A 417
Cdd:pfam04408  81 R 81
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 343-425 1.09e-18

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 80.78  E-value: 1.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   343 YLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAAlRRALEHADGDHS 422
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEKREDADAA-RRRFADPESDHL 79


                   ...
gi 568943289   423 SLI 425
Cdd:smart00847  80 TLL 82
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 486-569 2.55e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.60  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  486 LQKALLSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCSyrNRRTPAQPPTWVLYHSFSISKDNCLCIVSEIQPEMLVEL 565
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSV--LFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLF 78


                  ....
gi 568943289  566 APPY 569
Cdd:pfam07717  79 APHI 82
 
Name Accession Description Interval E-value
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-116 1.67e-54

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 183.18  E-value: 1.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17986   64 RSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKD 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TRLRNlpGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17986  144 VRLQR--PELRVVVVTSPALEPKLRAFWGNPPVVHV 177
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
2-510 3.19e-48

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 180.66  E-value: 3.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:COG1643   70 AAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  82 R------LRnlpgdprvVVVT----DPAlepKFQAFWGNSPIVRV------------PREPGGDptlaykdtvptDLVEA 139
Cdd:COG1643  150 QpalrpdLK--------LLVMsatlDAE---RFARLLGDAPVIESsgrtypvevryrPLPADER-----------DLEDA 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 140 ACQAVLELCQQEeaPGDVLVYLPSEEEISLCCESLSGEMgtlavpGPPPRVLPLH---PGCAQ--AIQTVYEDTdvsvRK 214
Cdd:COG1643  208 VADAVREALAEE--PGDILVFLPGEREIRRTAEALRGRL------PPDTEILPLYgrlSAAEQdrAFAPAPHGR----RR 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 215 IVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTlELEAPP 294
Cdd:COG1643  276 IVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEED-FARRPA 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 295 LPHPKVCEENLSSLVLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALL 374
Cdd:COG1643  355 FTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLL 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 375 ASCEFNCVDEMLTLAAMLTAapgftRPPL-SAGEAALRRALEHADGDHSSLiqvyEAFVQSGADEAWCQarglnweslcQ 453
Cdd:COG1643  435 AAAELGCLREAAILAALLSE-----RDPRrGAAGSDLLARLNLWRRLREQQ----REFLSYLRLREWRD----------L 495

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568943289 454 ARKLRAElvelmqrielpLSQPAFGSEQNRRDLQKALLSGYFLKVARDTDGTGNYLL 510
Cdd:COG1643  496 ARQLRRL-----------LGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYLL 541
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 132-283 1.43e-44

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 156.15  E-value: 1.43e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 132 VPTDLVEAACQAVLELCQQEEaPGDVLVYLPSEEEISLCCESLSGEMGTLavPGPPPRVLPLHPGCAQAIQT-VYEDTDV 210
Cdd:cd18791   22 EDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREELLSP--DLGKLLVLPLHSSLPPEEQQrVFEPPPP 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568943289 211 SVRKIVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLY 283
Cdd:cd18791   99 GVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-116 7.10e-39

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 140.29  E-value: 7.10e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17917   46 ISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKD 125

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 tRLRNLPgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17917  126 -LLRKRP-DLKVILMSATLDAEKFSSYFGGAPVIHI 159
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 2-566 2.47e-37

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 149.05  E-value: 2.47e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289    2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:PRK11131  133 TVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKEL 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   82 rlrnLPGDPRV-VVVTDPALEP-KFQAFWGNSPIVRV-----PREPGGDPTLAYKDTVPTDLVEAACQAVLELCqqEEAP 154
Cdd:PRK11131  213 ----LPRRPDLkVIITSATIDPeRFSRHFNNAPIIEVsgrtyPVEVRYRPIVEEADDTERDQLQAIFDAVDELG--REGP 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  155 GDVLVYLPSEEEISLCCESLSGEmgTLavpgPPPRVLPLHPGCAQAIQT-VYEDTdvSVRKIVVTHWLADFSFSLPSIQH 233
Cdd:PRK11131  287 GDILIFMSGEREIRDTADALNKL--NL----RHTEILPLYARLSNSEQNrVFQSH--SGRRIVLATNVAETSLTVPGIKY 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  234 VIDSGLELRSVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLeLEAPPLPHPKVCEENLSSLVLLLM 313
Cdd:PRK11131  359 VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDF-LSRPEFTDPEILRTNLASVILQMT 437

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  314 RKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDG-----ELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTL 388
Cdd:PRK11131  438 ALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMII 517

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  389 AAMLTAAPGFTRP---PLSAGEAalRRALEHADGDHSSLIQVYEaFVQSGADE-------AWCQARGLNWESLCQARKLR 458
Cdd:PRK11131  518 TSALSIQDPRERPmdkQQASDEK--HRRFADKESDFLAFVNLWN-YLQEQQKAlssnqfrRLCRTDYLNYLRVREWQDIY 594

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  459 AELVELMQRIELPL-SQPAfgseqNRRDLQKALLSGyflkvardtdgtgnylLLTH--KHVAQLSPYCSYRNRR---TPA 532
Cdd:PRK11131  595 TQLRQVVKELGIPVnSEPA-----EYREIHTALLTG----------------LLSHigMKDAEKQEYTGARNARfsiFPG 653

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 568943289  533 -----QPPTWVLYHSFSISKDNCLCIVSEIQPEMLVELA 566
Cdd:PRK11131  654 sglfkKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLA 692
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-116 6.50e-28

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 110.30  E-value: 6.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17977   63 VWLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKD 142

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TrLRNLPgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17977  143 V-LLSRP-ELKLVIITCPHLSSKLLSYYGNVPLIEV 176
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-116 1.07e-27

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 110.20  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17973   74 MSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKE 153

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TrLRNLPgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17973  154 V-VRRRP-DLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-116 1.65e-24

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 100.65  E-value: 1.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17974   61 MSVAARVAEEMGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKD 140

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568943289  81 -TRLRNlpgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17974  141 iARFRP---DLKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-113 8.85e-24

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 98.30  E-value: 8.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17983   60 MSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLRE 139

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568943289  81 TRLRNlpGDPRVVVVTDPALEPKFQAFWGNSPI 113
Cdd:cd17983  140 VVARR--RDLKLIVTSATMDADKFADFFGNVPI 170
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 2-394 5.84e-23

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 103.85  E-value: 5.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWD----RLfLQEVASTRGPgawSVLILDEAQERSVASDLLQGL 77
Cdd:PRK11664  63 NVAQRLAEQLGEKPGETVGYRMRAESKVGPNTRLEVVTEgiltRM-IQRDPELSGV---GLVILDEFHERSLQADLALAL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  78 LRDTR--LRNlpgDPRVVVVTDPALEPKFQAFWGNSPIVR-------VPREpggdptlaYKdTVPTD--LVEAACQAVLE 146
Cdd:PRK11664 139 LLDVQqgLRD---DLKLLIMSATLDNDRLQQLLPDAPVIVsegrsfpVERR--------YQ-PLPAHqrFDEAVARATAE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 147 LCQQEeaPGDVLVYLPSEEEISLCCESLSGEMGTLAVPGPPPRVLPLHPGcAQAIQTvyedTDVSVRKIVVTHWLADFSF 226
Cdd:PRK11664 207 LLRQE--SGSLLLFLPGVGEIQRVQEQLASRVASDVLLCPLYGALSLAEQ-QKAILP----APAGRRKVVLATNIAETSL 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 227 SLPSIQHVIDSGLELRSVYNPR---IRAESQvlRpISKCQAEARLLRAKGFPPGSCLRLYSKSTLElEAPPLPHPKVCEE 303
Cdd:PRK11664 280 TIEGIRLVVDSGLERVARFDPKtglTRLVTQ--R-ISQASMTQRAGRAGRLEPGICLHLYSKEQAE-RAAAQSEPEILHS 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289 304 NLSSLVLLLMRKQIAEPGECHFLDRPAPEALMRALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNcvD 383
Cdd:PRK11664 356 DLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--E 433

                        410
                 ....*....|.
gi 568943289 384 EMLTLAAMLTA 394
Cdd:PRK11664 434 AALATAAKLAA 444
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 1-117 8.87e-22

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 92.93  E-value: 8.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17971   65 MSVAKRVAEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKK 144

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568943289  81 TRLRNlpgdPRV-VVVTDPALEP-KFQAFWGNSPIVRVP 117
Cdd:cd17971  145 TVQKR----PDLkLIVTSATLDAvKFSQYFYEAPIFTIP 179
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 337-417 3.08e-21

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 88.83  E-value: 3.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  337 ALEDLDYLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAALRRALEH 416
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80


                  .
gi 568943289  417 A 417
Cdd:pfam04408  81 R 81
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 1-116 1.40e-20

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 89.53  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17984   60 ISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKK 139

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568943289  81 TRLRNLPG--DPRVVVVTDPALE-PKFQAFWGNSPIVRV 116
Cdd:cd17984  140 LFQEKSPNrkEHLKVVVMSATLElAKLSAFFGNCPVFDI 178
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 2-116 4.40e-20

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 87.80  E-value: 4.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:cd17978   61 SVAKRVAEEMGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSA 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568943289  82 -RLRNLPG-DPRVVVVTDPALEP-KFQAFWGNSPIVRV 116
Cdd:cd17978  141 qRRRKEQKlSPLKVIIMSATLDAdLFSEYFNGAPVLYI 178
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 343-425 1.09e-18

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 80.78  E-value: 1.09e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   343 YLAALNDDGELSDLGVILSEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAAlRRALEHADGDHS 422
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPKEKREDADAA-RRRFADPESDHL 79


                   ...
gi 568943289   423 SLI 425
Cdd:smart00847  80 TLL 82
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 2-108 1.10e-18

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 84.06  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGP-NTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRd 80
Cdd:cd17980   62 TVAGRVAEEMGAVLGHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLK- 140

                         90       100
                 ....*....|....*....|....*...
gi 568943289  81 tRLRNLPGDPRVVVVTDPALEPKFQAFW 108
Cdd:cd17980  141 -KIQKKRGDLRLIVASATLDAEKFRDFF 167
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 486-569 2.55e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 79.60  E-value: 2.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289  486 LQKALLSGYFLKVARDTDGTGNYLLLTHKHVAQLSPYCSyrNRRTPAQPPTWVLYHSFSISKDNCLCIVSEIQPEMLVEL 565
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSV--LFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLF 78


                  ....
gi 568943289  566 APPY 569
Cdd:pfam07717  79 APHI 82
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 2-116 7.74e-15

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 72.87  E-value: 7.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:cd17989   61 SVAERIAEELKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQL 140

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568943289  82 rlrnLPGDPRV-VVVTDPALEP-KFQAFWGNSPIVRV 116
Cdd:cd17989  141 ----LPRRPDLkVIITSATIDAeRFSRHFNNAPIIEV 173
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 2-85 1.46e-14

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 72.39  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLtLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLL-RD 80
Cdd:cd17982   66 SMAKRVAEELNV-FGKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsRI 144


                 ....*
gi 568943289  81 TRLRN 85
Cdd:cd17982  145 VPLRA 149
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 2-116 4.53e-09

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 55.91  E-value: 4.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDt 81
Cdd:cd17979   58 SLAKRVAFESLNQYGSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRC- 136

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568943289  82 rLRNLPGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17979  137 -LLRLRPDLKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 1-116 2.46e-08

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 54.08  E-value: 2.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEM--DLTLGHEIGYSI------PQEDCTgpntmLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASD 72
Cdd:cd17981   64 ISVAERVAAERaeSCGLGNSTGYQIrlesrkPRKQGS-----ILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSD 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568943289  73 LLQGLLRDtrLRNLPGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17981  139 VLMGIVKD--LLPFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 2-116 3.94e-07

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 50.41  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRDT 81
Cdd:cd17990   61 AAARRLATLLGEAPGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEV 140

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568943289  82 RlRNLPGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17990  141 Q-QLLRDDLRLLAMSATLDGDGLAALLPEAPVVES 174
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 1-116 9.56e-07

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 49.44  E-value: 9.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEV-ASTRGPGAWSVLILDEAQERSVASDLLQGLLR 79
Cdd:cd17987   62 IAVAERVAAERGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLR 141

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568943289  80 DTrlrnLPGDPRV-VVVTDPALEPK-FQAFWGNSPIVRV 116
Cdd:cd17987  142 DI----LQKHPNLkLILSSAALDVNlFIRYFGSCPVIYI 176
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 1-116 2.06e-06

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 48.25  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNT-MLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLR 79
Cdd:cd17976   64 VSVAQRVAHELGPNLRRNVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLK 143

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568943289  80 DtrLRNLPGDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17976  144 G--VLQLNPELRVVLMSATGDNQRLSRYFGGCPVVRV 178
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 1-116 2.82e-06

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 48.68  E-value: 2.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTG-PNTMLRFCWDRLFLQEVAStrGPGAWSVLILDEAQERSVASDLLQGLLR 79
Cdd:cd17972  122 VSVAERVAFERGEEVGKSCGYSVRFESVLPrPHASILFCTVGVLLRKLEA--GIRGISHVIVDEIHERDINTDFLLVVLR 199

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568943289  80 DTrLRNLPgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17972  200 DV-VQAYP-DLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 1-116 3.00e-06

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 47.91  E-value: 3.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568943289   1 MSLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD 80
Cdd:cd17985   64 ISVAERVAQERAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKD 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568943289  81 TrLRNLPgDPRVVVVTDPALEPKFQAFWGNSPIVRV 116
Cdd:cd17985  144 L-MVQRP-DLKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 2-74 1.56e-03

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 39.79  E-value: 1.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568943289   2 SLASRVADEMDLTLGHEIGYSIPQEDCTGPNTMLRFCWDRLFLQEVASTRGPGAWSVLILDEAQERSVASDLL 74
Cdd:cd17988   63 SIARRVSQEREWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH