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Conserved domains on  [gi|568942584|ref|XP_006506531|]
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MICOS complex subunit Mic19 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIC19_MIC25 super family cl25739
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-156 2.94e-23

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


The actual alignment was detected with superfamily member pfam05300:

Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 89.75  E-value: 2.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   29 SENVIDRMKESSPSGSKSQRY-----------------------------SSVYGASVSDEDLKRRVAEEL----ALEQA 75
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELykrlEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   76 KKESEhqrrlkQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLdiedkARQLEEKDRVMRKQDAFYKEQLARLEE 155
Cdd:pfam05300  81 KVQEE------LARLAEREREAAQESLTRAILRERASTEDERLKAQQL-----AKQLEEKEAELKKQDAFYKEQLARLEE 149


                  .
gi 568942584  156 R 156
Cdd:pfam05300 150 K 150
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-156 2.94e-23

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 89.75  E-value: 2.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   29 SENVIDRMKESSPSGSKSQRY-----------------------------SSVYGASVSDEDLKRRVAEEL----ALEQA 75
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELykrlEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   76 KKESEhqrrlkQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLdiedkARQLEEKDRVMRKQDAFYKEQLARLEE 155
Cdd:pfam05300  81 KVQEE------LARLAEREREAAQESLTRAILRERASTEDERLKAQQL-----AKQLEEKEAELKKQDAFYKEQLARLEE 149


                  .
gi 568942584  156 R 156
Cdd:pfam05300 150 K 150
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 59-156 8.86e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 35.68  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584  59 DEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLDIEDKARQLEEKDRV 138
Cdd:COG1196  280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359

                         90
                 ....*....|....*...
gi 568942584 139 MRKQDAFYKEQLARLEER 156
Cdd:COG1196  360 LAEAEEALLEAEAELAEA 377
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-156 2.94e-23

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 89.75  E-value: 2.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   29 SENVIDRMKESSPSGSKSQRY-----------------------------SSVYGASVSDEDLKRRVAEEL----ALEQA 75
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELykrlEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584   76 KKESEhqrrlkQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLdiedkARQLEEKDRVMRKQDAFYKEQLARLEE 155
Cdd:pfam05300  81 KVQEE------LARLAEREREAAQESLTRAILRERASTEDERLKAQQL-----AKQLEEKEAELKKQDAFYKEQLARLEE 149


                  .
gi 568942584  156 R 156
Cdd:pfam05300 150 K 150
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 59-156 8.86e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 35.68  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942584  59 DEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLDIEDKARQLEEKDRV 138
Cdd:COG1196  280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359

                         90
                 ....*....|....*...
gi 568942584 139 MRKQDAFYKEQLARLEER 156
Cdd:COG1196  360 LAEAEEALLEAEAELAEA 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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