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Conserved domains on  [gi|568934618|ref|XP_006504207|]
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protein furry homolog-like isoform X12 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2381-3112 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2381 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2460
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2461 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2540
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2541 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2620
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2621 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2699
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2700 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2779
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2780 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2859
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2860 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2937
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2938 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 3012
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  3013 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 3092
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 568934618  3093 QSYPLLAQTKPVGNMTSTGF 3112
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 213-745 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 631.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   213 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 292
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   293 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 372
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   373 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 452
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   453 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 530
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   531 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 608
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   609 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 674
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   675 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 745
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2098-2351 7.10e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.47  E-value: 7.10e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2098 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2176
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2177 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2254
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2255 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2333
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568934618  2334 PYWKEALNILKLVVSRSA 2351
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 783-1956 2.20e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.20e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   783 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 862
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   863 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 942
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   943 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 1022
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1023 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1096
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1097 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1176
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1177 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1229
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1230 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1272
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1273 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1351
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1352 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1430
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1431 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1508
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1509 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1563
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1564 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1643
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1644 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1709
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1710 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1789
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1790 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1869
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1870 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1948
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 568934618  1949 LVETVGDP 1956
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2381-3112 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2381 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2460
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2461 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2540
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2541 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2620
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2621 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2699
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2700 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2779
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2780 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2859
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2860 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2937
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2938 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 3012
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  3013 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 3092
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 568934618  3093 QSYPLLAQTKPVGNMTSTGF 3112
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 213-745 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 631.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   213 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 292
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   293 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 372
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   373 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 452
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   453 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 530
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   531 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 608
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   609 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 674
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   675 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 745
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2098-2351 7.10e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.47  E-value: 7.10e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2098 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2176
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2177 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2254
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2255 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2333
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568934618  2334 PYWKEALNILKLVVSRSA 2351
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 783-1956 2.20e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.20e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   783 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 862
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   863 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 942
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   943 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 1022
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1023 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1096
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1097 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1176
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1177 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1229
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1230 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1272
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1273 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1351
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1352 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1430
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1431 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1508
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1509 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1563
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1564 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1643
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1644 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1709
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1710 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1789
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1790 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1869
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1870 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1948
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 568934618  1949 LVETVGDP 1956
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2381-3112 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2381 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2460
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2461 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2540
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2541 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2620
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2621 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2699
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2700 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2779
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2780 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2859
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2860 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2937
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2938 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 3012
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  3013 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 3092
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 568934618  3093 QSYPLLAQTKPVGNMTSTGF 3112
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 213-745 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 631.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   213 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 292
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   293 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 372
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   373 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 452
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   453 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 530
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   531 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 608
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   609 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 674
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   675 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 745
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2098-2351 7.10e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.47  E-value: 7.10e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2098 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2176
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2177 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2254
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  2255 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2333
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568934618  2334 PYWKEALNILKLVVSRSA 2351
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 783-1956 2.20e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.20e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   783 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 862
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   863 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 942
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618   943 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 1022
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1023 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1096
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1097 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1176
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1177 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1229
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1230 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1272
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1273 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1351
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1352 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1430
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1431 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1508
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1509 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1563
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1564 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1643
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1644 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1709
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1710 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1789
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1790 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1869
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934618  1870 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1948
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 568934618  1949 LVETVGDP 1956
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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