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Conserved domains on  [gi|568934482|ref|XP_006504142|]
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major facilitator superfamily domain-containing protein 10 isoform X3 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-241 6.16e-90

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17389:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 391  Bit Score: 271.45  E-value: 6.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFLSV----------EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqd 70
Cdd:cd17389  170 MIGAYFASftrslgevffSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL----------------------- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  71 ppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRA 150
Cdd:cd17389  223 ---------------VYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQG 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 151 MLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLT 230
Cdd:cd17389  288 LILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLA 367

                        250
                 ....*....|.
gi 568934482 231 GAQVCFTVCSA 241
Cdd:cd17389  368 GSEACYTIGAL 378
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 1-241 6.16e-90

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 271.45  E-value: 6.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFLSV----------EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqd 70
Cdd:cd17389  170 MIGAYFASftrslgevffSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL----------------------- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  71 ppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRA 150
Cdd:cd17389  223 ---------------VYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQG 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 151 MLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLT 230
Cdd:cd17389  288 LILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLA 367

                        250
                 ....*....|.
gi 568934482 231 GAQVCFTVCSA 241
Cdd:cd17389  368 GSEACYTIGAL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-218 8.32e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 52.28  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLgfhtaAHLLSPLALLRFAAVThsqdppaehrlrnl 80
Cdd:COG2814  156 LLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-----RELLRRPRLLLLLLLA-------------- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  81 rrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLL 160
Cdd:COG2814  217 -------FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568934482 161 IGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRAL 218
Cdd:COG2814  290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
86-220 4.91e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAVTRAMLLLVPAFLLIG 162
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568934482  163 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGP 220
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 1-241 6.16e-90

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 271.45  E-value: 6.16e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFLSV----------EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqd 70
Cdd:cd17389  170 MIGAYFASftrslgevffSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL----------------------- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  71 ppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRA 150
Cdd:cd17389  223 ---------------VYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQG 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 151 MLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLT 230
Cdd:cd17389  288 LILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLA 367

                        250
                 ....*....|.
gi 568934482 231 GAQVCFTVCSA 241
Cdd:cd17389  368 GSEACYTIGAL 378
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 86-238 8.85e-24

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 98.03  E-value: 8.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISP-GKEAAAVTRAMLLLVPAFLLIGWA 164
Cdd:cd17330  182 VYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLLAIIGLLLLPFA 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934482 165 HSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTV 238
Cdd:cd17330  262 SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 2-241 1.52e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   2 LGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSPLALLRFAAVthsqdppaehrlrnlr 81
Cdd:cd17325  143 LADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFL---------------- 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  82 rlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLI 161
Cdd:cd17325  207 ----AIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 162 GWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:cd17325  283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 88-241 1.21e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.83  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  88 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTR-AMLLLVPAFLLIGWAHS 166
Cdd:cd17474  208 FLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILViGLLLYALSLLLLGFVPS 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568934482 167 LPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:cd17474  288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAA 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-218 8.32e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 52.28  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLgfhtaAHLLSPLALLRFAAVThsqdppaehrlrnl 80
Cdd:COG2814  156 LLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-----RELLRRPRLLLLLLLA-------------- 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  81 rrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLL 160
Cdd:COG2814  217 -------FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568934482 161 IGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRAL 218
Cdd:COG2814  290 LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 86-241 2.09e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.07  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAH 165
Cdd:cd17329  208 ASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568934482 166 SLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:cd17329  288 TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAA 363
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 88-231 6.24e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.88  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  88 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSL 167
Cdd:cd17473  207 FLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGL 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934482 168 PTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTG 231
Cdd:cd17473  287 WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 151-241 1.45e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 151 MLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLT 230
Cdd:cd17325   68 LLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL 147

                         90
                 ....*....|.
gi 568934482 231 GAQVCFTVCSA 241
Cdd:cd17325  148 GYRAPFLVCAA 158
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 86-223 2.98e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.61  E-value: 2.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLtMATIQGTYARRIS---PGKEAAAVTRAMLLLVPAFLLIG 162
Cdd:cd17390  180 VRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLVGRILklyKNNEYLLLLHSFILLALSLLGLA 258

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568934482 163 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVA 223
Cdd:cd17390  259 LAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLS 319
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-232 9.19e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 46.09  E-value: 9.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   1 MLGAFL---SVEMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFHTAAHLLSPLALLRFaavthsqdppaehrL 77
Cdd:cd17388  144 ALGGLLgeiSPRAPFLVAAGLNGLNFLLGLFVLPESLPPERR----RAFRWRRANPFGSLRWLTG--------------F 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  78 RNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPG-KEAAAVTRAMLLLVP 156
Cdd:cd17388  206 PGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRlGEKRAILLGLAADAL 285

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568934482 157 AFLLIGWAHSLPTLGLGLMLYSfAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGA 232
Cdd:cd17388  286 GFLLLAFATQGWMVFPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPA 360
MFS_1 pfam07690
Major Facilitator Superfamily;
86-220 4.91e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 4.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAVTRAMLLLVPAFLLIG 162
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568934482  163 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGP 220
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
88-241 7.19e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 7.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  88 FLYLFLFSGLEYTLSFLAH---QRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKeaaAVTRAMLLLVPAFLLI 161
Cdd:COG2271   16 FLAYFLNYLDRSNLSVAAPplqADLGLSAAQLGLLASAFFLGYALGQipaGLLADRFGRRR---VLAIGLLLWGLATLLF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 162 GWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:COG2271   93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
86-241 8.54e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 8.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAVTrAMLLLVPAFLLIG 162
Cdd:COG2271  188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSllgGWLSDRLGRRRKLVLAI-GLLLAALALLLLA 266

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934482 163 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:COG2271  267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
150-241 9.12e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 9.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 150 AMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWL 229
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         90
                 ....*....|..
gi 568934482 230 TGAQVCFTVCSA 241
Cdd:COG2814  161 FGWRWVFLVNAV 172
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-239 1.18e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   2 LGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFhtAAHLLSPLALLRFAAVthsqdppaehrlrnlr 81
Cdd:cd17324  146 LGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL--LLLLRNPRLRLAYLIT---------------- 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  82 rlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMA---TIQGTYARRISPGKEAAAvtrAMLLLVPAF 158
Cdd:cd17324  208 ------FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVvgsPLAGRLADRGGRRALLIA---LLLLAAALL 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 159 LLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYgSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTV 238
Cdd:cd17324  279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357


                 .
gi 568934482 239 C 239
Cdd:cd17324  358 G 358
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 88-241 1.41e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.60  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  88 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSL 167
Cdd:cd06173  218 ALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL 297

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568934482 168 PTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:cd06173  298 WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGA 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
88-241 2.43e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.79  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  88 FLYLFLFSGLEYTLSFLAH---QRFQFSSLQQG---KMFFFIGLTMATIQGTYARRISPGKeaaAVTRAMLLLVPAFLLI 161
Cdd:COG2223   11 TLAFFLAFGVWYLWSVLAPplaEEFGLSAAQLGllfAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 162 GWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:COG2223   88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 107-227 3.86e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 107 QRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAvtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAV 183
Cdd:cd17478   24 AKLGLSYAQAGLLVSVFSITSSLLQplfGYLADRKPRRYLLPL---GPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568934482 184 VVPGLSTMVSSYgSPGQKGTIMGILRSLGALGRALGPVVAASVY 227
Cdd:cd17478  101 FHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALV 143
MFS_1 pfam07690
Major Facilitator Superfamily;
86-241 9.28e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482   86 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKeaaAVTRAMLLLVPAFLLIG 162
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQplaGRLSDRFGRRR---VLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934482  163 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 100-227 3.16e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.35  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 100 TLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARR-ISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYS 178
Cdd:cd17331  229 MFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLV 308

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568934482 179 FAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVY 227
Cdd:cd17331  309 IGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 13-227 5.36e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 37.56  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  13 WISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSPLALLRFAAVThsqdppaehrlrnlRRLGLVYFLYLF 92
Cdd:cd17320  157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALAL--------------GLSFAGLFAYLA 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  93 lfsgleyTLSFLAHQRFQFSSLQQGKMFFFIGLTM---ATIQGTYARRISPGK--EAAAVTRAMLLLVPAFLLIGWAHSL 167
Cdd:cd17320  223 -------AAPFIYIEQLGLSPAQFGLLFALNAIALilgSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSL 295

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 168 PTLGLGLMLYSFAAAVVVPGLSTMVSSyGSPGQKGTIMGILRSLGALGRALGPVVAASVY 227
Cdd:cd17320  296 WPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 144-226 5.78e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 37.63  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 144 AAAVTRAMLLLVPAFLLIGWahslpTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVA 223
Cdd:cd17391  275 GALLASALLYIPQAFVQTPW-----QLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349


                 ...
gi 568934482 224 ASV 226
Cdd:cd17391  350 SAI 352
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
86-241 9.08e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 37.17  E-value: 9.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  86 VYFLYLFLFSGLEYTLSF----LAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAVtrAMLLLVPAF 158
Cdd:COG2223  209 LLSLLYFGTFGSFIGFSSwlppYLVDQFGLSAATAGLLAALFALLGALGRplgGWLSDRIGGRRVLLIV--FALMALGLL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 159 LLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGA-QVCFT 237
Cdd:COG2223  287 LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFL 366


                 ....
gi 568934482 238 VCSA 241
Cdd:COG2223  367 VFAV 370
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 57-241 9.64e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 36.75  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482  57 LALLRFAAVTHSQDPPAEHRLRNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYA- 135
Cdd:cd17370  170 LLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYAl 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934482 136 ---------RRISPGKEAAAvtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMG 206
Cdd:cd17370  250 aaypagrlsDRIGRKKLLIL---GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568934482 207 ILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 241
Cdd:cd17370  327 LFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAV 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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