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Conserved domains on  [gi|568934318|ref|XP_006504065|]
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phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3 [Mus musculus]

Protein Classification

phosphatidylserine decarboxylase( domain architecture ID 999)

phosphatidylserine decarboxylase catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)

EC:  4.1.1.65
Gene Ontology:  GO:0004609|GO:0006646
PubMed:  27650064|9370338
SCOP:  4007787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 35-338 5.86e-87

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 268.23  E-value: 5.86e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  35 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 113
Cdd:PLN02938  84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 114 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 172
Cdd:PLN02938 163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 173 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 252
Cdd:PLN02938 243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 253 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 318
Cdd:PLN02938 323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                        330       340
                 ....*....|....*....|...
gi 568934318 319 ---KDFNFRLKAGQKIRFGEALG 338
Cdd:PLN02938 401 qssSDFRFCVRKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 35-338 5.86e-87

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 268.23  E-value: 5.86e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  35 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 113
Cdd:PLN02938  84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 114 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 172
Cdd:PLN02938 163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 173 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 252
Cdd:PLN02938 243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 253 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 318
Cdd:PLN02938 323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                        330       340
                 ....*....|....*....|...
gi 568934318 319 ---KDFNFRLKAGQKIRFGEALG 338
Cdd:PLN02938 401 qssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 96-338 3.41e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 227.55  E-value: 3.41e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318   96 LSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRAntedlpfppasssdsfrnql 174
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  175 vTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 254
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  255 TNVGSIRIHFdrdlhtnspryskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFG 334
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 568934318  335 EALG 338
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 82-338 1.70e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 227.02  E-value: 1.70e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318   82 MTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantEDLP 160
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  161 FppassSDSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 240
Cdd:TIGR00163  76 L-----SPYFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  241 DWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 317
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 568934318  318 PKDFNFRLKAGQKIRFGEALG 338
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 46-340 3.33e-57

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 185.44  E-value: 3.33e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  46 PTRLLSRACGRLNQVELPYWlrRPVYSLYIWTFGVNMTEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGK 124
Cdd:COG0688    1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 125 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDlpfppasssdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 203
Cdd:COG0688   76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 204 TISHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdrdlhtnspryskgsyndl 283
Cdd:COG0688  135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568934318 284 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 340
Cdd:COG0688  194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 35-338 5.86e-87

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 268.23  E-value: 5.86e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  35 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 113
Cdd:PLN02938  84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 114 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 172
Cdd:PLN02938 163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 173 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 252
Cdd:PLN02938 243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 253 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 318
Cdd:PLN02938 323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                        330       340
                 ....*....|....*....|...
gi 568934318 319 ---KDFNFRLKAGQKIRFGEALG 338
Cdd:PLN02938 401 qssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 96-338 3.41e-74

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 227.55  E-value: 3.41e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318   96 LSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRAntedlpfppasssdsfrnql 174
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  175 vTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 254
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  255 TNVGSIRIHFdrdlhtnspryskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFG 334
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 568934318  335 EALG 338
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 82-338 1.70e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 227.02  E-value: 1.70e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318   82 MTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantEDLP 160
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  161 FppassSDSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 240
Cdd:TIGR00163  76 L-----SPYFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  241 DWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 317
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 568934318  318 PKDFNFRLKAGQKIRFGEALG 338
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 46-340 3.23e-62

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 199.02  E-value: 3.23e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  46 PTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEaaVEDLHHYRNLSEFFRRKLKPQaRPV-CGLHCVTSPSDGK 124
Cdd:PRK03934   3 LSNALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFdEDPNIFISPCDSL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 125 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDLPFppasssdSFRNqlvtregnelyhcvIYLAPGDYHCFHSPTDWT 204
Cdd:PRK03934  80 ITECGSLEEDKALQIKGMEYSIEELLGESNSELVNGF-------DYIN--------------FYLSPKDYHRYHAPCDLE 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 205 ISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHG-FFSLTAVGATNVGSIRIHFDRDLHTNSpryskgsynDL 283
Cdd:PRK03934 139 ILEARYIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNA---------KA 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568934318 284 SFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 340
Cdd:PRK03934 210 RFIQTYEYENLKLKKGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 47-338 6.21e-60

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 196.23  E-value: 6.21e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  47 TRLL-----SRACGRLNQVELPYWLRRPVYSLYIWTFGVNmTEAAVEDLHHYRNLSEFFRRKLKPQARPV--CGLHCVTS 119
Cdd:PTZ00403  57 ARLLfgrtrSRITGSIFNIEIPNTYRLPIYNFLIKYMGIN-KEEIKYPIESYKSIGDFFSRYIREETRPIgdVSDYSIVS 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 120 PSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantedLPFPPASSSDSfrnqlvtregNELYHCVIYLAPGDYHCFHS 199
Cdd:PTZ00403 136 PCDSELTDYGELSSEYLENVKGVKFNVNTFLG-------SDMQKKYNDGS----------TKFFYAIFYLSPKKYHHFHA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 200 PTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR----Y 275
Cdd:PTZ00403 199 PFNFKYKIRRHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLRtqlsY 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568934318 276 SKGSYNDLSFVTHANKEgipmrKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFGEALG 338
Cdd:PTZ00403 279 MGGDINTKIYDSYKSVE-----VGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLG 336
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 45-338 1.57e-59

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 193.12  E-value: 1.57e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  45 VPTRLLSRACGRLNQVELPyWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDG 123
Cdd:PRK00044  13 LPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPIDeDPNALVSPADG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 124 KILTFGQVKNSEVEQVKGVTYSLESFLGpraNTEDLpfppassSDSFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTD 202
Cdd:PRK00044  92 AISQLGPIEDGQIFQAKGHSYSLEALLG---GDAAL-------ADPFRNgSFAT----------IYLSPRDYHRVHMPCD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 203 WTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRihfdrdlhT------NSPRY- 275
Cdd:PRK00044 152 GTLREMIYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSIE--------TvwagtvTPPREg 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568934318 276 --SKGSYNDlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFEAPK-DFNFRLKAGQKIRFGEALG 338
Cdd:PRK00044 224 iiKRWDYPE------AGDGAITLKKGAEMGRFKLGSTVINLFPPGKvQLAEQLQAGSVVRMGQPLA 283
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 46-340 3.33e-57

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 185.44  E-value: 3.33e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  46 PTRLLSRACGRLNQVELPYWlrRPVYSLYIWTFGVNMTEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGK 124
Cdd:COG0688    1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 125 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDlpfppasssdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 203
Cdd:COG0688   76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 204 TISHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdrdlhtnspryskgsyndl 283
Cdd:COG0688  135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568934318 284 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 340
Cdd:COG0688  194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 66-340 9.33e-33

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 122.40  E-value: 9.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  66 LRRPVYSLYIWTFGVNMTEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTY 144
Cdd:PRK03140  30 LSSILIPSYAKVYQINQDEME-KGLKEYRTLHELFTRKLKEGKRPIdTDASSIVSPVDGVFADVGPIEDDKTFDVKGKRY 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 145 SLESFLGprantedlpfppasssdsfrNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISH-----RRHFPgslmsVN 219
Cdd:PRK03140 109 SIAEMLG--------------------NEERAQRYAGGTYMVLYLSPSHYHRIHSPISGTVTEqfvlgRKSYP-----VN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 220 PGMARWIKELFCHNERVV--LTGDWKHgfFSLTAVGATNVGSIRIhfdrdlhtnspryskgsyndlsfvTHANKEgipMR 297
Cdd:PRK03140 164 ALGLEYGKRPLSKNYRSVteVNSDGEH--MALVKVGAMFVNSIEL------------------------THERDT---VQ 214

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568934318 298 KGEPLGEFNLGSTIVLIFEapKD---FNFRLKAGQKIRFGEALGSL 340
Cdd:PRK03140 215 KGEEMAYFSFGSTVVLLFE--KDmiePDQELKSGQEVRLGEKIGTR 258
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 78-338 8.41e-32

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 120.79  E-value: 8.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  78 FGVNMTEAAvEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprant 156
Cdd:PRK00723  69 FNIDMSESE-KPLSDFKSFNDFFTRKLKPEARPIDqGENILISPGDGRLLAYENIDLNSLFQVKGKTYSLKELLG----- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 157 edlpfppasssdsfrNQLVTREgnelYH---CVIY-LAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCH 232
Cdd:PRK00723 143 ---------------DPELAKK----YAggtCLILrLCPTDYHRFHFPDSGICEETRKIKGHYYSVNPIALKKIFELFCE 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 233 NER--VVLTGDwKHGFFSLTAVGATNVGSIrihfdrdLHTNSPryskgsyndlsfvthankeGIPMRKGEPLGEFNL-GS 309
Cdd:PRK00723 204 NKRewSIFKSE-NFGDILYVEVGATCVGSI-------IQTYKP-------------------NKKVKKGDEKGYFKFgGS 256

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568934318 310 TIVLIFEAPK-----DF--NFRLKAGQKIRFGEALG 338
Cdd:PRK00723 257 TVILFFEKNKikidaDIleQSKLGYETKVLMGESIG 292
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 45-338 9.96e-31

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 122.53  E-value: 9.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  45 VPTRLLSRACGRLNQVELpYWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPV-CGLHCVTSPSDG 123
Cdd:PRK09629 336 LPHHLLSRLAGCVAECRV-RWFKNAFTAWFARRYQVDMSQALVEDLTSYEHFNAFFTRALKADARPLdTTPGAILSPADG 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 124 KILTFGQVKNSEVEQVKGVTYSLESFLG--PRANTedlPFppasssdsfrnqlvtrEGNELyhCVIYLAPGDYHCFHSPT 201
Cdd:PRK09629 415 AISQLGPIDHGRIFQAKGHSFSVLELLGgdPKLSA---PF----------------MGGEF--ATVYLSPKDYHRVHMPL 473

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 202 DWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPRYSKGSYN 281
Cdd:PRK09629 474 AGTLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETVWAGLVTPPKRELKTFSYD 553

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568934318 282 DlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFeAPKDFNF--RLKAGQKIRFGEALG 338
Cdd:PRK09629 554 E------AARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 80-317 4.66e-21

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 94.16  E-value: 4.66e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318  80 VNMTEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLH--CVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRANT 156
Cdd:PLN02964 401 INMDEVK-YPLEHFKTFNEFFIRELKPGARPIaCMDNddVAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGKKVHS 479

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 157 EDLPFPPasssdsfrnqlvtregnelyhCVIY-LAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPgMARWIK--ELFCHN 233
Cdd:PLN02964 480 DAFLDGS---------------------LVIFrLAPQDYHRFHVPVSGVIEKFVDVPGSLYTVNP-IAVNSKycNVFTEN 537

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934318 234 ERVV-LTGDWKHGFFSLTAVGATNVGSIrihfdrdlhtnspryskgsyndlsfvTHANKEGIPMRKGEPLGEFNLG-STI 311
Cdd:PLN02964 538 KRAVcIISTAEFGKVAFVAIGATMVGSI--------------------------TFVKKEGDHVKKGDELGYFSFGgSTV 591


                 ....*.
gi 568934318 312 VLIFEA 317
Cdd:PLN02964 592 ICVFEK 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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