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Conserved domains on  [gi|568933887|ref|XP_006503854|]
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prominin-1 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Prominin super family cl25943
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
7-469 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


The actual alignment was detected with superfamily member pfam05478:

Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 659.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887    7 KGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLNNSNRYLNQELPKLEEYDSYWWLGG 86
Cdd:pfam05478 342 EGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIHNTERSSRTFLDVVEKYGSYRWLIG 420
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887   87 LIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLCEP 166
Cdd:pfam05478 421 LILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFFWFLMLVVLLYFLVGGNTYTLVCAP 500
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  167 YENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQLENVVNVSDHFNIDQISENINTEL 246
Cdd:pfam05478 501 WENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLRLNNIYDISKLLNISVYTEEIQQEL 577
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  247 ENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQLPEGKLKQAFLLDVQNI 326
Cdd:pfam05478 578 ENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADKLEGLANSLPNGNLKVSLQNEAQDL 657
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  327 RAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTILGYFEHYLHWV 406
Cdd:pfam05478 658 RAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSSIINNESENLLDRIMGYFEQYIDWV 737
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568933887  407 FYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAIKLAKYYR 469
Cdd:pfam05478 738 IEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAVKLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
7-469 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 659.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887    7 KGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLNNSNRYLNQELPKLEEYDSYWWLGG 86
Cdd:pfam05478 342 EGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIHNTERSSRTFLDVVEKYGSYRWLIG 420
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887   87 LIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLCEP 166
Cdd:pfam05478 421 LILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFFWFLMLVVLLYFLVGGNTYTLVCAP 500
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  167 YENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQLENVVNVSDHFNIDQISENINTEL 246
Cdd:pfam05478 501 WENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLRLNNIYDISKLLNISVYTEEIQQEL 577
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  247 ENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQLPEGKLKQAFLLDVQNI 326
Cdd:pfam05478 578 ENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADKLEGLANSLPNGNLKVSLQNEAQDL 657
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  327 RAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTILGYFEHYLHWV 406
Cdd:pfam05478 658 RAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSSIINNESENLLDRIMGYFEQYIDWV 737
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568933887  407 FYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAIKLAKYYR 469
Cdd:pfam05478 738 IEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAVKLAKYYR 799
 
Name Accession Description Interval E-value
Prominin pfam05478
Prominin; The prominins are an emerging family of proteins that among the multispan membrane ...
7-469 0e+00

Prominin; The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration.


Pssm-ID: 461660 [Multi-domain]  Cd Length: 799  Bit Score: 659.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887    7 KGYTTIDEIPNTIQNQTVDVIKDVKNTLDSISSNIKDMSQSIPiEDMLLQVSHYLNNSNRYLNQELPKLEEYDSYWWLGG 86
Cdd:pfam05478 342 EGLDRFNNIPEKVKNQTAGVVPPLKRALAQIREQIRTLATDIP-RDALSAVSSDIHNTERSSRTFLDVVEKYGSYRWLIG 420
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887   87 LIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRGCVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVVGANVEKLLCEP 166
Cdd:pfam05478 421 LILCSLILLIVVCLLLGLLCGICGLRRTATPTDRGCSKNTGARFLMVGVGLSFLFFWFLMLVVLLYFLVGGNTYTLVCAP 500
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  167 YENKKLLQVLDTPYLLkeqWQFYLSGMLFNNPDINMTFEQVYRDCKRGRGIYAAFQLENVVNVSDHFNIDQISENINTEL 246
Cdd:pfam05478 501 WENNELFRFLDTPGLL---PEIDLSRYLPGGLKPNLTISQAYSACKANQSIFTVLRLNNIYDISKLLNISVYTEEIQQEL 577
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  247 ENLNVNIDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQLPEGKLKQAFLLDVQNI 326
Cdd:pfam05478 578 ENLKVDLSNIDLLTPEERRDLEALRESGLSTIHYSLYLQQLCKPFTKVNLLTLADKLEGLANSLPNGNLKVSLQNEAQDL 657
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933887  327 RAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSVQHFLTNNVSLIVIGETKKFGKTILGYFEHYLHWV 406
Cdd:pfam05478 658 RAIHQEFVLPLQSLVAKLNQSVKELDSSNNDLNNSITNLLDAVERAENFLPNNGSSIINNESENLLDRIMGYFEQYIDWV 737
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568933887  407 FYAITEKMTSCKPMATAMDSAVNgILCGYVADPLNLFWFGIGKATVLLLPAVIIAIKLAKYYR 469
Cdd:pfam05478 738 IEEVTENVGHCKPLAYAYDSGVV-LLCDRLVDPINAFWFGLGWCTLLLLPSIIFAVKLAKYYR 799
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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