NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568929692|ref|XP_006503434|]
View 

cilia- and flagella-associated protein 57 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 340-606 3.21e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 3.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  340 VLCLCFSPSEETLI-ASTNKnqlysiTMSLTEISKGEAAHFeyllYPLHSASITGLDTCIRKPLIATCSLDRSVRIWNYE 418
Cdd:cd00200    12 VTCVAFSPDGKLLAtGSGDG------TIKVWDLETGELLRT----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  419 SN-TLELYKEYQEEAYTVSLHPSGHYIVVGFADKlrlmNLLIDDIRPFK-EYSVRGCKE----CSFS-NGGHLFAAVNGN 491
Cdd:cd00200    82 TGeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDK----TIKVWDVETGKcLTTLRGHTDwvnsVAFSpDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  492 VIHIFTTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRamKYPLSLQKEYNEYQAHAGPVMK 571
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEV-----------NSVAFSPDGEKLLSSSSDGTIK--LWDLSTGKCLGTLRGHENGVNS 224

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568929692  572 MLLTFDDQFLLTVGEDGclfTWKVFDKDGRGIKRE 606
Cdd:cd00200   225 VAFSPDGYLLASGSEDG---TIRVWDLRTGECVQT 256
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 757-1094 1.36e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 1.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   757 EFYEAKLQEKTGLLEEA------QEDVRQQLREFEETKKQIEEDED--REI---------QDIKTKYERKLRDEKEsNLR 819
Cdd:TIGR02168  148 EIIEAKPEERRAIFEEAagiskyKERRKETERKLERTRENLDRLEDilNELerqlkslerQAEKAERYKELKAELR-ELE 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   820 LkgetGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR02168  227 L----ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   900 FKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVR 979
Cdd:TIGR02168  303 QKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLE 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   980 RFKTDLHncvayiqepgLLKEKIRGLfEKYVQRADmVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYV 1059
Cdd:TIGR02168  383 TLRSKVA----------QLELQIASL-NNEIERLE-ARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE 450

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 568929692  1060 RIMQENVSLIKEINELRRELKLTRSQIYDLESALK 1094
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELA 485
sbcc super family cl31020
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 613-899 2.65e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00618:

Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.43  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   613 EEVLVTKTDMEEKAQIMLELKTRVEELKME---NEYQLRLKDMNYTEKIKELTDKFIQEMESLktknqvLKTEKEKQDIS 689
Cdd:TIGR00618  593 TVRLQDLTEKLSEAEDMLACEQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTALHALQLTL------TQERVREHALS 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   690 HRERLEELVDKQTRELQDLEccnNQKLLLEYEKYQELQLKSQ-RMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTG 768
Cdd:TIGR00618  667 IRVLPKELLASRQLALQKMQ---SEKEQLTYWKEMLAQCQTLlRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   769 LLEEAQEDVRQQLREFEETKKQIEEDEDREIQdIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEE----RTND 844
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQ-TGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSdediLNLQ 822

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692   845 IELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR00618  823 CETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
WD40 super family cl43672
WD40 repeat [General function prediction only];
26-189 1.44e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   26 DEQIIIFPSGNHCVK-YNID-QKWQKFIAGSdkSQGMLALAISPNRRYLAiseTVQEKPAVTIYELSSipcrkRKVLNNF 103
Cdd:COG2319   215 DGKLLASGSADGTVRlWDLAtGKLLRTLTGH--SGSVRSVAFSPDGRLLA---SGSADGTVRLWDLAT-----GELLRTL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  104 DFQVQKFTSMAFSPDSKYLLTQTSppDSNLVYWLWEKQKVMAIIKADSqnNPIYQVSISSqDNSQVcITGS--GVFKLLR 181
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSP-DGKTL-ASGSddGTVRLWD 358


                  ....*...
gi 568929692  182 FAEGTLKQ 189
Cdd:COG2319   359 LATGELLR 366
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 340-606 3.21e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 3.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  340 VLCLCFSPSEETLI-ASTNKnqlysiTMSLTEISKGEAAHFeyllYPLHSASITGLDTCIRKPLIATCSLDRSVRIWNYE 418
Cdd:cd00200    12 VTCVAFSPDGKLLAtGSGDG------TIKVWDLETGELLRT----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  419 SN-TLELYKEYQEEAYTVSLHPSGHYIVVGFADKlrlmNLLIDDIRPFK-EYSVRGCKE----CSFS-NGGHLFAAVNGN 491
Cdd:cd00200    82 TGeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDK----TIKVWDVETGKcLTTLRGHTDwvnsVAFSpDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  492 VIHIFTTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRamKYPLSLQKEYNEYQAHAGPVMK 571
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEV-----------NSVAFSPDGEKLLSSSSDGTIK--LWDLSTGKCLGTLRGHENGVNS 224

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568929692  572 MLLTFDDQFLLTVGEDGclfTWKVFDKDGRGIKRE 606
Cdd:cd00200   225 VAFSPDGYLLASGSEDG---TIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
340-595 1.22e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  340 VLCLCFSPSEETLiASTNKNQlysiTMSLTEISKGEAAHfeylLYPLHSASITGLDTCIRKPLIATCSLDRSVRIWNYES 419
Cdd:COG2319   165 VTSVAFSPDGKLL-ASGSDDG----TVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  420 NT-LELYKEYQEEAYTVSLHPSGHYIVVGFADK-LRLMNLLIDDIRPFKEYSVRGCKECSFS-NGGHLFAAVNGNVIHIF 496
Cdd:COG2319   236 GKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLW 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  497 TTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRAmkYPLSLQKEYNEYQAHAGPVMKMLLTF 576
Cdd:COG2319   316 DLATGKLLRTLTGHTGAV-----------RSVAFSPDGKTLASGSDDGTVRL--WDLATGELLRTLTGHTGAVTSVAFSP 382

                         250
                  ....*....|....*....
gi 568929692  577 DDQFLLTVGEDGCLFTWKV 595
Cdd:COG2319   383 DGRTLASGSADGTVRLWDL 401
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 757-1094 1.36e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 1.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   757 EFYEAKLQEKTGLLEEA------QEDVRQQLREFEETKKQIEEDED--REI---------QDIKTKYERKLRDEKEsNLR 819
Cdd:TIGR02168  148 EIIEAKPEERRAIFEEAagiskyKERRKETERKLERTRENLDRLEDilNELerqlkslerQAEKAERYKELKAELR-ELE 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   820 LkgetGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR02168  227 L----ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   900 FKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVR 979
Cdd:TIGR02168  303 QKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLE 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   980 RFKTDLHncvayiqepgLLKEKIRGLfEKYVQRADmVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYV 1059
Cdd:TIGR02168  383 TLRSKVA----------QLELQIASL-NNEIERLE-ARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE 450

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 568929692  1060 RIMQENVSLIKEINELRRELKLTRSQIYDLESALK 1094
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELA 485
PTZ00121 PTZ00121
MAEBL; Provisional
 604-996 3.54e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 81.34  E-value: 3.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  604 KREREVGFAEEvLVTKTDMEEKAQimlELKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEK 683
Cdd:PTZ00121 1438 KKAEEAKKADE-AKKKAEEAKKAE---EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  684 EKQDISHRERLEELVD-KQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAK 762
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAR 1593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  763 LQEKTGLLEEAQEDVRQQLREFEETKKQIE-----EDEDREIQDIKTKYERKLRdeKESNLRlKGETGIMRKKFSSLQKE 837
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEelkkaEEEKKKVEQLKKKEAEEKK--KAEELK-KAEEENKIKAAEEAKKA 1670

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  838 IEERTNDIELLKSEQMKlqgiirslEKDIQGLKREIQERDETIQDKeKRIYDLKKKNQELEKFKFVLDYKIKELKKQiep 917
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDE--------KKAAEALKKEAEEAKKAEELK-KKEAEEKKKAEELKKAEEENKIKAEEAKKE--- 1738

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692  918 rENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEalVRRFKTDLHNCVAYIQEPG 996
Cdd:PTZ00121 1739 -AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRME--VDKKIKDIFDNFANIIEGG 1814
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 721-1046 1.38e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.74  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  721 EKYQELQLKsqrmQEEYEKQLRdndetkSQALEELtefyEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEdedreiq 800
Cdd:COG1196   213 ERYRELKEE----LKELEAELL------LLKLREL----EAELEELEAELEELEAELEELEAELAELEAELEE------- 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  801 diktkyerklrdekesnlrlkgetgiMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETI 880
Cdd:COG1196   272 --------------------------LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  881 QDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRAT 960
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  961 DQEM-RKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLERN 1039
Cdd:COG1196   406 EEAEeALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE 485


                  ....*..
gi 568929692 1040 LATLKKK 1046
Cdd:COG1196   486 LAEAAAR 492
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 668-1161 7.32e-12

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 69.77  E-value: 7.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   668 EMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQDLEccnnqkllLEYEKYQELQLKSQRMQEEYEKQlrdndet 747
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLD--------RESDRNQELQKRIRLLEKREAEA------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   748 ksqaleeltefyEAKLQEKTglleeaqEDVRQQLREFEETKKQIEEDEDreiqdiktkyerKLRDEKESNLRLKGETgim 827
Cdd:pfam05557   68 ------------EEALREQA-------ELNRLKKKYLEALNKKLNEKES------------QLADAREVISCLKNEL--- 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   828 rkkfSSLQKEIEErtNDIELlkseqmklqgiiRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEkfkfVLDYK 907
Cdd:pfam05557  114 ----SELRRQIQR--AELEL------------QSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLA----EAEQR 171

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   908 IKELKKQIEPREN---EIKVMKE---QIQEMEAELERFHKQNTQLELNI------TELLQKLRATDQEMRKEQQKERDLE 975
Cdd:pfam05557  172 IKELEFEIQSQEQdseIVKNSKSelaRIPELEKELERLREHNKHLNENIenklllKEEVEDLKRKLEREEKYREEAATLE 251

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   976 ALVRRFKTDLHNCVAYIQEPGL---LKEKIRGLFEKYVQR--ADMVEIAGLNSDLQQEYARQREhLERNLATLKKKVIKE 1050
Cdd:pfam05557  252 LEKEKLEQELQSWVKLAQDTGLnlrSPEDLSRRIEQLQQReiVLKEENSSLTSSARQLEKARRE-LEQELAQYLKKIEDL 330

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1051 G-ELHRTD-YVRIMQENVSLI-KEINELRRELKLTRSQIYDLESALKVSKKTRSQE---------VPESVISKDVVGSTS 1118
Cdd:pfam05557  331 NkKLKRHKaLVRRLQRRVLLLtKERDGYRAILESYDKELTMSNYSPQLLERIEEAEdmtqkmqahNEEMEAQLSVAEEEL 410

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692  1119 T---------------MRLNEQ-----------EETGRIIEMQRLEIRRLRDQIQEQEQVPGFHTIAGV 1161
Cdd:pfam05557  411 GgykqqaqtlerelqaLRQQESladpsyskeevDSLRRKLETLELERQRLREQKNELEMELERRCLQGD 479
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 601-901 1.29e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.90  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   601 RGIKREREVGFAEEVlvTKTDMEEKAQIMLELktrvEELKMENEYQLrlkdmnytEKIKELTDKfiQEMESLKTKNQVLK 680
Cdd:pfam17380  310 REVERRRKLEEAEKA--RQAEMDRQAAIYAEQ----ERMAMEREREL--------ERIRQEERK--RELERIRQEEIAME 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   681 TEKekqdISHRERLE-ELVDKQTRELQDLECCNNQKLLLEyekyqELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFY 759
Cdd:pfam17380  374 ISR----MRELERLQmERQQKNERVRQELEAARKVKILEE-----ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEER 444

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   760 EAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKfSSLQKEIE 839
Cdd:pfam17380  445 AREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKR-KLLEKEME 523

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   840 ERTNDIelLKSEQMKLQGIIRSLEKDIQGlKREIQERDETIQDKEKRIYDLKKKNQELEKFK 901
Cdd:pfam17380  524 ERQKAI--YEEERRREAEEERRKQQEMEE-RRRIQEQMRKATEERSRLEAMEREREMMRQIV 582
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 744-941 9.38e-06

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 48.91  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  744 NDETKSQALEELTEFYEAKLQEKTGLLEEAQEdVRQQLREFEetkKQIEEDEDrEIQDIKTKYERKLRDEKESnlrlkge 823
Cdd:cd22656   108 DDEELEEAKKTIKALLDDLLKEAKKYQDKAAK-VVDKLTDFE---NQTEKDQT-ALETLEKALKDLLTDEGGA------- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  824 tgIMRKKFSSLQKEIEErtndiellkseqmKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKknqelekfkfv 903
Cdd:cd22656   176 --IARKEIKDLQKELEK-------------LNEEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTA----------- 229

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568929692  904 LDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHK 941
Cdd:cd22656   230 ADTDLDNLLALIGPAIPALEKLQGAWQAIATDLDSLKD 267
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 613-899 2.65e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.43  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   613 EEVLVTKTDMEEKAQIMLELKTRVEELKME---NEYQLRLKDMNYTEKIKELTDKFIQEMESLktknqvLKTEKEKQDIS 689
Cdd:TIGR00618  593 TVRLQDLTEKLSEAEDMLACEQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTALHALQLTL------TQERVREHALS 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   690 HRERLEELVDKQTRELQDLEccnNQKLLLEYEKYQELQLKSQ-RMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTG 768
Cdd:TIGR00618  667 IRVLPKELLASRQLALQKMQ---SEKEQLTYWKEMLAQCQTLlRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   769 LLEEAQEDVRQQLREFEETKKQIEEDEDREIQdIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEE----RTND 844
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQ-TGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSdediLNLQ 822

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692   845 IELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR00618  823 CETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
PRK12704 PRK12704
phosphodiesterase; Provisional
 609-817 3.19e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  609 VGFAEEVLVTKTDMEEKAQIMLEL-KTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEmesLKTKNQVLKtEKEKQD 687
Cdd:PRK12704   16 VGAVIGYFVRKKIAEAKIKEAEEEaKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKE---LRERRNELQ-KLEKRL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  688 ISHrerlEELVDKQTRELQDLEccnnqkllleyekyQELQLKsqrmQEEYEKQLRDNDETKSQaLEELTEFYEAKLQEKT 767
Cdd:PRK12704   92 LQK----EENLDRKLELLEKRE--------------EELEKK----EKELEQKQQELEKKEEE-LEELIEEQLQELERIS 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568929692  768 GLleeAQEDVRQQLreFEETKKQIEEDEDREIQDIKTKYerKLRDEKESN 817
Cdd:PRK12704  149 GL---TAEEAKEIL--LEKVEEEARHEAAVLIKEIEEEA--KEEADKKAK 191
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 745-1151 1.24e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  745 DETKSQALEELTEFYEAKLQEktglleeaqedVRQQLREFEETKKQieeDEDREIQDIKTKYERKLRDEKEsnlrlKGET 824
Cdd:NF033838   53 NESQKEHAKEVESHLEKILSE-----------IQKSLDKRKHTQNV---ALNKKLSDIKTEYLYELNVLKE-----KSEA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  825 GIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDK----EKRIYDLKKKNQELEKF 900
Cdd:NF033838  114 ELTSKTKKELDAAFEQFKKDTLEPGKKVAEATKKVEEAEKKAKDQKEEDRRNYPTNTYKtlelEIAESDVEVKKAELELV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  901 KFVL-----DYKIKELKKQIEPRENEIKVMKE-QIQEMEAELERFHKQNTQLELNITELlqkLRATDQEMRKEQQKERDL 974
Cdd:NF033838  194 KEEAkeprdEEKIKQAKAKVESKKAEATRLEKiKTDREKAEEEAKRRADAKLKEAVEKN---VATSEQDKPKRRAKRGVL 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  975 EALVRRFK--TDLHNCVAYIQE-----PGLLKEKIRGLFEKYVQRAdmveiaglnsdlQQEYARQREHLERNLATLKKKV 1047
Cdd:NF033838  271 GEPATPDKkeNDAKSSDSSVGEetlpsPSLKPEKKVAEAEKKVEEA------------KKKAKDQKEEDRRNYPTNTYKT 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1048 IkEGELHRTDyVRIMQENVSLIKEI-NELRRELKLTRSQIyDLESalKVSKKTRSQEVpesviskdvvgstSTMRLNEQE 1126
Cdd:NF033838  339 L-ELEIAESD-VKVKEAELELVKEEaKEPRNEEKIKQAKA-KVES--KKAEATRLEKI-------------KTDRKKAEE 400

                         410       420
                  ....*....|....*....|....*
gi 568929692 1127 ETGRIIEmqrlEIRRLRDQIQEQEQ 1151
Cdd:NF033838  401 EAKRKAA----EEDKVKEKPAEQPQ 421
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-416 9.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 9.59e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568929692    384 YPLHSASITGLDTCIRKPLIATCSLDRSVRIWN 416
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
26-189 1.44e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   26 DEQIIIFPSGNHCVK-YNID-QKWQKFIAGSdkSQGMLALAISPNRRYLAiseTVQEKPAVTIYELSSipcrkRKVLNNF 103
Cdd:COG2319   215 DGKLLASGSADGTVRlWDLAtGKLLRTLTGH--SGSVRSVAFSPDGRLLA---SGSADGTVRLWDLAT-----GELLRTL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  104 DFQVQKFTSMAFSPDSKYLLTQTSppDSNLVYWLWEKQKVMAIIKADSqnNPIYQVSISSqDNSQVcITGS--GVFKLLR 181
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSP-DGKTL-ASGSddGTVRLWD 358


                  ....*...
gi 568929692  182 FAEGTLKQ 189
Cdd:COG2319   359 LATGELLR 366
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 728-902 3.41e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.16  E-value: 3.41e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692    728 LKSQRMQEEYEKQLRDNDEtksqalEELTEFYEAKLQEKTGLLEEAQE--DVRQQLRE-FEETKKQIEEdedreiqdikt 804
Cdd:smart00787  128 LEAKKMWYEWRMKLLEGLK------EGLDENLEGLKEDYKLLMKELELlnSIKPKLRDrKDALEEELRQ----------- 190

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692    805 kyERKLRDEKESNLrlKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIqdKE 884
Cdd:smart00787  191 --LKQLEDELEDCD--PTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKL--EQ 264

                           170
                    ....*....|....*...
gi 568929692    885 KRIYDLKKKNQELEKFKF 902
Cdd:smart00787  265 CRGFTFKEIEKLKEQLKL 282
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 657-783 5.09e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  657 KIKELTDKFIQEMES-----LKTKNQVLKTEKEKQdishrerleelVDKQTRELQDLEccnnQKLLLEYEKYQELQLKSQ 731
Cdd:cd16269   167 KAEEVLQEFLQSKEAeaeaiLQADQALTEKEKEIE-----------AERAKAEAAEQE----RKLLEEQQRELEQKLEDQ 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568929692  732 -RMQEEYEKQLRDN-DETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLRE 783
Cdd:cd16269   232 eRSYEEHLRQLKEKmEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQE 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 340-606 3.21e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 3.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  340 VLCLCFSPSEETLI-ASTNKnqlysiTMSLTEISKGEAAHFeyllYPLHSASITGLDTCIRKPLIATCSLDRSVRIWNYE 418
Cdd:cd00200    12 VTCVAFSPDGKLLAtGSGDG------TIKVWDLETGELLRT----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  419 SN-TLELYKEYQEEAYTVSLHPSGHYIVVGFADKlrlmNLLIDDIRPFK-EYSVRGCKE----CSFS-NGGHLFAAVNGN 491
Cdd:cd00200    82 TGeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDK----TIKVWDVETGKcLTTLRGHTDwvnsVAFSpDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  492 VIHIFTTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRamKYPLSLQKEYNEYQAHAGPVMK 571
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEV-----------NSVAFSPDGEKLLSSSSDGTIK--LWDLSTGKCLGTLRGHENGVNS 224

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568929692  572 MLLTFDDQFLLTVGEDGclfTWKVFDKDGRGIKRE 606
Cdd:cd00200   225 VAFSPDGYLLASGSEDG---TIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
340-595 1.22e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  340 VLCLCFSPSEETLiASTNKNQlysiTMSLTEISKGEAAHfeylLYPLHSASITGLDTCIRKPLIATCSLDRSVRIWNYES 419
Cdd:COG2319   165 VTSVAFSPDGKLL-ASGSDDG----TVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  420 NT-LELYKEYQEEAYTVSLHPSGHYIVVGFADK-LRLMNLLIDDIRPFKEYSVRGCKECSFS-NGGHLFAAVNGNVIHIF 496
Cdd:COG2319   236 GKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLW 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  497 TTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRAmkYPLSLQKEYNEYQAHAGPVMKMLLTF 576
Cdd:COG2319   316 DLATGKLLRTLTGHTGAV-----------RSVAFSPDGKTLASGSDDGTVRL--WDLATGELLRTLTGHTGAVTSVAFSP 382

                         250
                  ....*....|....*....
gi 568929692  577 DDQFLLTVGEDGCLFTWKV 595
Cdd:COG2319   383 DGRTLASGSADGTVRLWDL 401
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 757-1094 1.36e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 1.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   757 EFYEAKLQEKTGLLEEA------QEDVRQQLREFEETKKQIEEDED--REI---------QDIKTKYERKLRDEKEsNLR 819
Cdd:TIGR02168  148 EIIEAKPEERRAIFEEAagiskyKERRKETERKLERTRENLDRLEDilNELerqlkslerQAEKAERYKELKAELR-ELE 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   820 LkgetGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR02168  227 L----ALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   900 FKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVR 979
Cdd:TIGR02168  303 QKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLE 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   980 RFKTDLHncvayiqepgLLKEKIRGLfEKYVQRADmVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYV 1059
Cdd:TIGR02168  383 TLRSKVA----------QLELQIASL-NNEIERLE-ARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE 450

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 568929692  1060 RIMQENVSLIKEINELRRELKLTRSQIYDLESALK 1094
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELA 485
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 624-965 9.62e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.81  E-value: 9.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   624 EKAQIMLELKTRVEELkmenEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELvDKQTR 703
Cdd:TIGR02169  208 EKAERYQALLKEKREY----EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL-NKKIK 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   704 ELQDLECCNNQKLLLEYEKYQElqlKSQRMQEEYEKQLRDNDETKSQALEELTefyeaKLQEKTGLLEEAQEDVRQQLRE 783
Cdd:TIGR02169  283 DLGEEEQLRVKEKIGELEAEIA---SLERSIAEKERELEDAEERLAKLEAEID-----KLLAEIEELEREIEEERKRRDK 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   784 FEEtkkqieededrEIQDIKTKYERKLRDEKEsnlrLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQgiirsle 863
Cdd:TIGR02169  355 LTE-----------EYAELKEELEDLRAELEE----VDKEFAETRDELKDYREKLEKLKREINELKRELDRLQ------- 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   864 kdiqglkREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQN 943
Cdd:TIGR02169  413 -------EELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL 485

                          330       340
                   ....*....|....*....|..
gi 568929692   944 TQLELNITELLQKLRATDQEMR 965
Cdd:TIGR02169  486 SKLQRELAEAEAQARASEERVR 507
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 692-975 1.03e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.81  E-value: 1.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   692 ERLEELVDKQTRELQDLECCNNQKllleyEKYQELQLKSQ-RMQEEYEKQLRDNDETKSQALEELTEFyEAKLQEKTGLL 770
Cdd:TIGR02169  187 ERLDLIIDEKRQQLERLRREREKA-----ERYQALLKEKReYEGYELLKEKEALERQKEAIERQLASL-EEELEKLTEEI 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   771 EEAQEDVRQQLREFEETKKQIE---EDEDREIQ----DIKTKYERKLRDEKESNLRLKGETGIMRKKFS---SLQKEIEE 840
Cdd:TIGR02169  261 SELEKRLEEIEQLLEELNKKIKdlgEEEQLRVKekigELEAEIASLERSIAEKERELEDAEERLAKLEAeidKLLAEIEE 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   841 RTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQ-------DKEKRIYDLKKKNQELEKFKFVLDYKIKELKK 913
Cdd:TIGR02169  341 LEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAetrdelkDYREKLEKLKREINELKRELDRLQEELQRLSE 420

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   914 QIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLE 975
Cdd:TIGR02169  421 ELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVE 482
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 748-1094 1.99e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.64  E-value: 1.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   748 KSQALEELTEFYEaKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNlRLKGETGIM 827
Cdd:TIGR02168  675 RRREIEELEEKIE-ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYK 907
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   908 IKELKKQIEPRENEIKVMKEQIQ--------------EMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERD 973
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIEslaaeieeleelieELESELEALLNERASLEEALALLRSELEELSEELRELESKRSE 912

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   974 LEALVRRFKTDLHNCVAYIQEpglLKEKIRGLFEK----YVQRADMVEIAGLNSDLQQEYARQRehlernLATLKKKVIK 1049
Cdd:TIGR02168  913 LRRELEELREKLAQLELRLEG---LEVRIDNLQERlseeYSLTLEEAEALENKIEDDEEEARRR------LKRLENKIKE 983

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 568929692  1050 EGELhrtdyvrimqeNVSLIKEINELRRELKLTRSQIYDLESALK 1094
Cdd:TIGR02168  984 LGPV-----------NLAAIEEYEELKERYDFLTAQKEDLTEAKE 1017
PTZ00121 PTZ00121
MAEBL; Provisional
 604-996 3.54e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 81.34  E-value: 3.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  604 KREREVGFAEEvLVTKTDMEEKAQimlELKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEK 683
Cdd:PTZ00121 1438 KKAEEAKKADE-AKKKAEEAKKAE---EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  684 EKQDISHRERLEELVD-KQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAK 762
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAR 1593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  763 LQEKTGLLEEAQEDVRQQLREFEETKKQIE-----EDEDREIQDIKTKYERKLRdeKESNLRlKGETGIMRKKFSSLQKE 837
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEelkkaEEEKKKVEQLKKKEAEEKK--KAEELK-KAEEENKIKAAEEAKKA 1670

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  838 IEERTNDIELLKSEQMKlqgiirslEKDIQGLKREIQERDETIQDKeKRIYDLKKKNQELEKFKFVLDYKIKELKKQiep 917
Cdd:PTZ00121 1671 EEDKKKAEEAKKAEEDE--------KKAAEALKKEAEEAKKAEELK-KKEAEEKKKAEELKKAEEENKIKAEEAKKE--- 1738

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692  918 rENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEalVRRFKTDLHNCVAYIQEPG 996
Cdd:PTZ00121 1739 -AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRME--VDKKIKDIFDNFANIIEGG 1814
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 668-966 1.64e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 78.96  E-value: 1.64e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   668 EMESLKTKNQVLKTEKEKQdISHRERLEELVDKQTRELQDLEccnnqKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDET 747
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSL-QSELRRIENRLDELSQELSDAS-----RKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS 748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   748 KSQALEEltefYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIM 827
Cdd:TIGR02169  749 LEQEIEN----VKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRL 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYK 907
Cdd:TIGR02169  825 TLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERK 904

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568929692   908 IKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQL------ELNITELLQKLRATDQEMRK 966
Cdd:TIGR02169  905 IEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDeeipeeELSLEDVQAELQRVEEEIRA 969
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 620-933 3.21e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 77.37  E-value: 3.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   620 TDMEEKAQIMLELKTRVEELKMENEyQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKT-EKEKQDISHR-ERLEEL 697
Cdd:TIGR04523  356 SENSEKQRELEEKQNEIEKLKKENQ-SYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKlQQEKELLEKEiERLKET 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   698 VDKQTRELQDLECCNNQKLLL-----EYEKYQELQLKSqrMQEEYEKQLRDNDETKSQALEELTEFyeAKLQEKTGLLEE 772
Cdd:TIGR04523  435 IIKNNSEIKDLTNQDSVKELIiknldNTRESLETQLKV--LSRSINKIKQNLEQKQKELKSKEKEL--KKLNEEKKELEE 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   773 AQEDVRQQLREFEETKKQIEededREIQDIKTKYERKLRDEKESNLRLKGETgiMRKKFSSLQKEIEERTNDIELLKSEQ 852
Cdd:TIGR04523  511 KVKDLTKKISSLKEKIEKLE----SEKKEKESKISDLEDELNKDDFELKKEN--LEKEIDEKNKEIEELKQTQKSLKKKQ 584

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   853 MKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEM 932
Cdd:TIGR04523  585 EEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEI 664


                   .
gi 568929692   933 E 933
Cdd:TIGR04523  665 I 665
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 792-1091 3.42e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.80  E-value: 3.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   792 EEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKR 871
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   872 EIQERDETIQDKEKRIYDLKKKNQELEK-----FKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQL 946
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEalndlEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   947 ELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEpglLKEKIRGLFEkyvQRADMVEIAGLNSDLQ 1026
Cdd:TIGR02169  832 EKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRD---LESRLGDLKK---ERDELEAQLRELERKI 905

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568929692  1027 QEYARQREHLERNLATLK-KKVIKEGEL-HRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLES 1091
Cdd:TIGR02169  906 EELEAQIEKKRKRLSELKaKLEALEEELsEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEP 972
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 654-984 3.81e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 77.37  E-value: 3.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   654 YTEKIKELTDkfiqEMESLKTKNQVLKTEKEKQDishrerlEELVDKQTrELQDleccNNQKLLLEYEKYQELQLKSQRM 733
Cdd:TIGR04523  209 KIQKNKSLES----QISELKKQNNQLKDNIEKKQ-------QEINEKTT-EISN----TQTQLNQLKDEQNKIKKQLSEK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   734 QEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDE------DREIQDIK---- 803
Cdd:TIGR04523  273 QKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNkiisqlNEQISQLKkelt 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   804 -------------TKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLK 870
Cdd:TIGR04523  353 nsesensekqrelEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLK 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   871 REIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNI 950
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV 512

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 568929692   951 TELLQK---LRATDQEMRKEQ-QKERDLEALVRRFKTD 984
Cdd:TIGR04523  513 KDLTKKissLKEKIEKLESEKkEKESKISDLEDELNKD 550
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 721-1046 1.38e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.74  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  721 EKYQELQLKsqrmQEEYEKQLRdndetkSQALEELtefyEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEdedreiq 800
Cdd:COG1196   213 ERYRELKEE----LKELEAELL------LLKLREL----EAELEELEAELEELEAELEELEAELAELEAELEE------- 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  801 diktkyerklrdekesnlrlkgetgiMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETI 880
Cdd:COG1196   272 --------------------------LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  881 QDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRAT 960
Cdd:COG1196   326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  961 DQEM-RKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLERN 1039
Cdd:COG1196   406 EEAEeALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE 485


                  ....*..
gi 568929692 1040 LATLKKK 1046
Cdd:COG1196   486 LAEAAAR 492
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 631-1099 1.95e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 75.06  E-value: 1.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   631 ELKTRVEELKMENEYQLRLKD-MNYTEKIKELTDKFI-----------QEMESLKTKNQVLKTEKEKQDISHRERLEELV 698
Cdd:TIGR04523  104 DLSKINSEIKNDKEQKNKLEVeLNKLEKQKKENKKNIdkflteikkkeKELEKLNNKYNDLKKQKEELENELNLLEKEKL 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   699 DKQtrelQDLECCNNQKLLLEY---------EKYQELQLKSQRMQEEyEKQLRDNDETKSQALEELTEFYEAKLQEKTGL 769
Cdd:TIGR04523  184 NIQ----KNIDKIKNKLLKLELllsnlkkkiQKNKSLESQISELKKQ-NNQLKDNIEKKQQEINEKTTEISNTQTQLNQL 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   770 LEEAQEDVRQ---QLREFEETKKQIEEDEDReIQDIKTKYErKLRDEKESNL--RLKGETGIMRKKFSSLQKEIEERTND 844
Cdd:TIGR04523  259 KDEQNKIKKQlseKQKELEQNNKKIKELEKQ-LNQLKSEIS-DLNNQKEQDWnkELKSELKNQEKKLEEIQNQISQNNKI 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   845 IELLKSEqmklqgiIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldyKIKELKKQIEPRENEIKV 924
Cdd:TIGR04523  337 ISQLNEQ-------ISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQ-------EIKNLESQINDLESKIQN 402

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   925 MKEQIQEMEAELERFHKQNTQLELNITELLQklratdqEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEpglLKEKIrg 1004
Cdd:TIGR04523  403 QEKLNQQKDEQIKKLQQEKELLEKEIERLKE-------TIIKNNSEIKDLTNQDSVKELIIKNLDNTRES---LETQL-- 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1005 lfekyvqradmveiaglnSDLQQEYARQREHLERNLATLKKKVikegelhrtdyvrimqenvsliKEINELRRELKLTRS 1084
Cdd:TIGR04523  471 ------------------KVLSRSINKIKQNLEQKQKELKSKE----------------------KELKKLNEEKKELEE 510

                          490
                   ....*....|....*
gi 568929692  1085 QIYDLESALKVSKKT 1099
Cdd:TIGR04523  511 KVKDLTKKISSLKEK 525
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
613-1080 4.06e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.94  E-value: 4.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  613 EEVLVTKTDMEEKAQIMLELKTRVEELKmENEYQLRLKDMNYTEKIKELTDKfIQEMESLKTKNQVLKTEKE--KQDISH 690
Cdd:PRK03918  279 EEKVKELKELKEKAEEYIKLSEFYEEYL-DELREIEKRLSRLEEEINGIEER-IKELEEKEERLEELKKKLKelEKRLEE 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  691 RERLEELVDKQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEA--KLQEKTG 768
Cdd:PRK03918  357 LEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAieELKKAKG 436

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  769 --------LLEEAQEDV----RQQLREFEETKKQIEEDEdREIQDIKTKYERKLRDEKE--SNLRLKGETGIMRKKFSSL 834
Cdd:PRK03918  437 kcpvcgreLTEEHRKELleeyTAELKRIEKELKEIEEKE-RKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKY 515

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  835 QKE-IEERTNDIELLKSEQMKLQGIIRSLEKDI---QGLKREIQERDETIQDKEKRIYDLKKknqELEKFKFVLDYKIKE 910
Cdd:PRK03918  516 NLEeLEKKAEEYEKLKEKLIKLKGEIKSLKKELeklEELKKKLAELEKKLDELEEELAELLK---ELEELGFESVEELEE 592

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  911 LKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLElNITELLQKLRATDQEMRKEqqkerdLEALVRRFKtdlhncva 990
Cdd:PRK03918  593 RLKELEPFYNEYLELKDAEKELEREEKELKKLEEELD-KAFEELAETEKRLEELRKE------LEELEKKYS-------- 657

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  991 yiqepgllKEKIRGLFEKYVQRADmvEIAGLNSDLqQEYARQREHLERNLATLK--KKVIKEGELHRTDYVRIMQENVSL 1068
Cdd:PRK03918  658 --------EEEYEELREEYLELSR--ELAGLRAEL-EELEKRREEIKKTLEKLKeeLEEREKAKKELEKLEKALERVEEL 726

                         490
                  ....*....|..
gi 568929692 1069 IKEINELRRELK 1080
Cdd:PRK03918  727 REKVKKYKALLK 738
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 745-1102 6.78e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.56  E-value: 6.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   745 DETKSQALEELTEfyeakLQEKTGLLEEAQEDVRQQLrefeetkkqieededreiqdiktkyeRKLRDEKESNLRlkget 824
Cdd:TIGR02169  169 DRKKEKALEELEE-----VEENIERLDLIIDEKRQQL--------------------------ERLRREREKAER----- 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   825 gimrkkFSSLQKEIEERTNDIELLKSEQMKLQgiIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQEL-EKFKFV 903
Cdd:TIGR02169  213 ------YQALLKEKREYEGYELLKEKEALERQ--KEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELnKKIKDL 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   904 LDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKT 983
Cdd:TIGR02169  285 GEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKE 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   984 DLHNCVAYIQEpglLKEKIRGLFEKYVQRADMVEiaglnsdlqqEYARQREHLERNLATL---KKKVIKEGELHRTDYVR 1060
Cdd:TIGR02169  365 ELEDLRAELEE---VDKEFAETRDELKDYREKLE----------KLKREINELKRELDRLqeeLQRLSEELADLNAAIAG 431

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 568929692  1061 IMQENVSLIKEINELRRELKLTRSQiydLESALKVSKKTRSQ 1102
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWK---LEQLAADLSKYEQE 470
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 618-1151 7.73e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.17  E-value: 7.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   618 TKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDmnYTEKIKELtdkfiqEMESLKTKNQVLKTEKEKQDiSHRERLEEL 697
Cdd:TIGR02168  184 TRENLDRLEDILNELERQLKSLERQAEKAERYKE--LKAELREL------ELALLVLRLEELREELEELQ-EELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   698 VDKQTRELQDLEccnnqkllleyEKYQELQLKSQRMQEEYEKQLRDNDETKS--QALEELTEFYEAKLQEKTGLLEEAQE 775
Cdd:TIGR02168  255 LEELTAELQELE-----------EKLEELRLEVSELEEEIEELQKELYALANeiSRLEQQKQILRERLANLERQLEELEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   776 DVRQQLREFEETKKQIEEDEDrEIQDIKTKYErklrDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKL 855
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEE-KLEELKEELE----SLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   856 QGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKnqelekfkfvldykikELKKQIEPRENEIKVMKEQIQEMEAE 935
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELK----------------ELQAELEELEEELEELQEELERLEEA 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   936 LERFHKQntqlelnITELLQKLRATDQEMRKEQQKERDLEALVRRFKtDLHNCVAYIQEP--------GLLKEKIRglFE 1007
Cdd:TIGR02168  463 LEELREE-------LEEAEQALDAAERELAQLQARLDSLERLQENLE-GFSEGVKALLKNqsglsgilGVLSELIS--VD 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1008 KYVQRAdmVEIAgLNSDLQQEYARQREHLERNLATLKKK-----------VIKEGELHRTDYVRIMQEN------VSLIK 1070
Cdd:TIGR02168  533 EGYEAA--IEAA-LGGRLQAVVVENLNAAKKAIAFLKQNelgrvtflpldSIKGTEIQGNDREILKNIEgflgvaKDLVK 609

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1071 EINELRRELKLTRSQIY---DLESALKVSKKTRSQEvpeSVISKD--VVGSTSTMRLNEQEETGRIIEmQRLEIRRLRDQ 1145
Cdd:TIGR02168  610 FDPKLRKALSYLLGGVLvvdDLDNALELAKKLRPGY---RIVTLDgdLVRPGGVITGGSAKTNSSILE-RRREIEELEEK 685


                   ....*.
gi 568929692  1146 IQEQEQ 1151
Cdd:TIGR02168  686 IEELEE 691
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 337-547 8.09e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 8.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  337 KQDVLCLCFSPSEETLIASTNKNqlysiTMSLTEISKGEAAHfeylLYPLHSASITGLDTCIRKPLIATCSLDRSVRIWN 416
Cdd:cd00200    93 TSYVSSVAFSPDGRILSSSSRDK-----TIKVWDVETGKCLT----TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  417 YESNTL-ELYKEYQEEAYTVSLHPSGHYIVVGFADKlrlmNLLIDDIRPFKE-YSVRGCKE----CSFSNGGHLFAAVNG 490
Cdd:cd00200   164 LRTGKCvATLTGHTGEVNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKClGTLRGHENgvnsVAFSPDGYLLASGSE 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692  491 -NVIHIFTTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIR 547
Cdd:cd00200   240 dGTIRVWDLRTGECVQTLSGHTNSV-----------TSLAWSPDGKRLASGSADGTIR 286
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
640-1094 4.87e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.48  E-value: 4.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  640 KMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKtkNQVLKTEKEKQDISHR-ERLEELVDKQTRELQDLEccnnqKLLL 718
Cdd:PRK03918  159 DYENAYKNLGEVIKEIKRRIERLEKFIKRTENIE--ELIKEKEKELEEVLREiNEISSELPELREELEKLE-----KEVK 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  719 EYEKYQELQLKSQRMQEEYEKQLRdndetksqaleeltefyeaKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEdedre 798
Cdd:PRK03918  232 ELEELKEEIEELEKELESLEGSKR-------------------KLEEKIRELEERIEELKKEIEELEEKVKELKE----- 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  799 IQDIKTKYER--KLRDEKESNLR-LKGETGIMRKKFSSLQKEIEERTND---IELLKSEQMKLQGIIRSLEKDIQGLK-- 870
Cdd:PRK03918  288 LKEKAEEYIKlsEFYEEYLDELReIEKRLSRLEEEINGIEERIKELEEKeerLEELKKKLKELEKRLEELEERHELYEea 367

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  871 REIQERDETIQDKEK--RIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEME----------AELER 938
Cdd:PRK03918  368 KAKKEELERLKKRLTglTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTE 447

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  939 FHKQNTqlelnITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEkIRGLFEKyvqradmveI 1018
Cdd:PRK03918  448 EHRKEL-----LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQ-LKELEEK---------L 512

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929692 1019 AGLNSDLQQEYARQREHLERNLATLKKKVIkegelhrtdyvRIMQEnvslIKEINELRRELKLTRSQIYDLESALK 1094
Cdd:PRK03918  513 KKYNLEELEKKAEEYEKLKEKLIKLKGEIK-----------SLKKE----LEKLEELKKKLAELEKKLDELEEELA 573
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 618-987 6.76e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 70.05  E-value: 6.76e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   618 TKTDMEEKAQIMLELKTRVEELKME-NEYQLRLKDMNyTEKIKELTDKFIQEMESLKTKNQVLKTE--KEKQDIShreRL 694
Cdd:TIGR04523  265 IKKQLSEKQKELEQNNKKIKELEKQlNQLKSEISDLN-NQKEQDWNKELKSELKNQEKKLEEIQNQisQNNKIIS---QL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   695 EELVDKQTRELQDLECCNNQKLLLEYEKYQELQlKSQRMQEEYEKQLRdNDETKSQALEELTEFYEAKLQEKTGLLEEAQ 774
Cdd:TIGR04523  341 NEQISQLKKELTNSESENSEKQRELEEKQNEIE-KLKKENQSYKQEIK-NLESQINDLESKIQNQEKLNQQKDEQIKKLQ 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   775 EDVRQQLREFEETKKQIEEDED------REIQDIKTKYER--KLRDEKESNLR-LKGETGIMRKKFSSLQKEIEERTNDI 845
Cdd:TIGR04523  419 QEKELLEKEIERLKETIIKNNSeikdltNQDSVKELIIKNldNTRESLETQLKvLSRSINKIKQNLEQKQKELKSKEKEL 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   846 ELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKK---------KNQELEKFKFVLDYKIKELKKQI- 915
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDelnkddfelKKENLEKEIDEKNKEIEELKQTQk 578

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692   916 ------EPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHN 987
Cdd:TIGR04523  579 slkkkqEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKE 656
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 668-1161 7.32e-12

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 69.77  E-value: 7.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   668 EMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQDLEccnnqkllLEYEKYQELQLKSQRMQEEYEKQlrdndet 747
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLD--------RESDRNQELQKRIRLLEKREAEA------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   748 ksqaleeltefyEAKLQEKTglleeaqEDVRQQLREFEETKKQIEEDEDreiqdiktkyerKLRDEKESNLRLKGETgim 827
Cdd:pfam05557   68 ------------EEALREQA-------ELNRLKKKYLEALNKKLNEKES------------QLADAREVISCLKNEL--- 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   828 rkkfSSLQKEIEErtNDIELlkseqmklqgiiRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEkfkfVLDYK 907
Cdd:pfam05557  114 ----SELRRQIQR--AELEL------------QSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLA----EAEQR 171

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   908 IKELKKQIEPREN---EIKVMKE---QIQEMEAELERFHKQNTQLELNI------TELLQKLRATDQEMRKEQQKERDLE 975
Cdd:pfam05557  172 IKELEFEIQSQEQdseIVKNSKSelaRIPELEKELERLREHNKHLNENIenklllKEEVEDLKRKLEREEKYREEAATLE 251

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   976 ALVRRFKTDLHNCVAYIQEPGL---LKEKIRGLFEKYVQR--ADMVEIAGLNSDLQQEYARQREhLERNLATLKKKVIKE 1050
Cdd:pfam05557  252 LEKEKLEQELQSWVKLAQDTGLnlrSPEDLSRRIEQLQQReiVLKEENSSLTSSARQLEKARRE-LEQELAQYLKKIEDL 330

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1051 G-ELHRTD-YVRIMQENVSLI-KEINELRRELKLTRSQIYDLESALKVSKKTRSQE---------VPESVISKDVVGSTS 1118
Cdd:pfam05557  331 NkKLKRHKaLVRRLQRRVLLLtKERDGYRAILESYDKELTMSNYSPQLLERIEEAEdmtqkmqahNEEMEAQLSVAEEEL 410

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692  1119 T---------------MRLNEQ-----------EETGRIIEMQRLEIRRLRDQIQEQEQVPGFHTIAGV 1161
Cdd:pfam05557  411 GgykqqaqtlerelqaLRQQESladpsyskeevDSLRRKLETLELERQRLREQKNELEMELERRCLQGD 479
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 641-979 8.36e-12

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 69.77  E-value: 8.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   641 MENEYQLRLKDMNYTEKikELTDKFIQEMESLKTKNQvlKTEKEKQDISHRERLEELVDKQTRELQdleccnNQKLLLEY 720
Cdd:pfam17380  252 MTPEYTVRYNGQTMTEN--EFLNQLLHIVQHQKAVSE--RQQQEKFEKMEQERLRQEKEEKAREVE------RRRKLEEA 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   721 EKYQELQLKSQ--------RMQEEYEKQL-RDNDETKSQALEELTEFYEAKLQEKTGLLEEAQ-------EDVRQQLrEF 784
Cdd:pfam17380  322 EKARQAEMDRQaaiyaeqeRMAMERERELeRIRQEERKRELERIRQEEIAMEISRMRELERLQmerqqknERVRQEL-EA 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   785 EETKKQIEEDEDREIQDIKTKYErKLRDEKESNLRLKgetgimrkkfssLQKEIEERTNDIELLKSEQMKLQGIIRSLEK 864
Cdd:pfam17380  401 ARKVKILEEERQRKIQQQKVEME-QIRAEQEEARQRE------------VRRLEEERAREMERVRLEEQERQQQVERLRQ 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   865 DIQGLKREIQERDETiQDKEKRIYDLKKK--NQELEKFKFVL---DYKIKELKKQIEPRENEIKvmkEQIQEMEAELERf 939
Cdd:pfam17380  468 QEEERKRKKLELEKE-KRDRKRAEEQRRKilEKELEERKQAMieeERKRKLLEKEMEERQKAIY---EEERRREAEEER- 542

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 568929692   940 hkqNTQLELnitellQKLRATDQEMRKEQQKERDLEALVR 979
Cdd:pfam17380  543 ---RKQQEM------EERRRIQEQMRKATEERSRLEAMER 573
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 619-1151 3.47e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 68.07  E-value: 3.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   619 KTDMEEKAQIMLELKTRVEELK--MENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDI------SH 690
Cdd:pfam02463  155 RLEIEEEAAGSRLKRKKKEALKklIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLlyldylKL 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   691 RERLEELVDKQTRELQDLECCNNQKLLLEYEKyQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTGLL 770
Cdd:pfam02463  235 NEERIDLLQELLRDEQEEIESSKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDE 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   771 EEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKgetgimrkkfssLQKEIEERTNDIELLKS 850
Cdd:pfam02463  314 EKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKL------------QEKLEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   851 EQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVM--KEQ 928
Cdd:pfam02463  382 ESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQelKLL 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   929 IQEMEAELERFHKQNTQL-ELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDL-HNCVAYIQEPGLLKEKIRGLF 1006
Cdd:pfam02463  462 KDELELKKSEDLLKETQLvKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGvGGRIISAHGRLGDLGVAVENY 541

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1007 EKYVQRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRImQENVSLIKEINELRRELKLTRSQI 1086
Cdd:pfam02463  542 KVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV-LEIDPILNLAQLDKATLEADEDDK 620

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568929692  1087 YDLESALKVSKKTRSQEVPESVISKDVVGSTSTMRLNEQEETGRIIEMQRLEIRRLRDQIQEQEQ 1151
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKA 685
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 623-977 3.47e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.77  E-value: 3.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   623 EEKAQIMLELKTRVEELKMENEyQLRLKDMNYTEKIKELTDKFiQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQT 702
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIE-ELEEKIAELEKALAELRKEL-EELEEELEQLRKELEELSRQISALRKDLARLEAEVE 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   703 RELQDLEccNNQKLLLEYEKYqelqlksqrmQEEYEKQLRDNDETKSQALEELtefyeAKLQEKTGLLEEAQEDVRQQLR 782
Cdd:TIGR02168  744 QLEERIA--QLSKELTELEAE----------IEELEERLEEAEEELAEAEAEI-----EELEAQIEQLKEELKALREALD 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   783 EFEETKKQiEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSL 862
Cdd:TIGR02168  807 ELRAELTL-LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASL 885

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   863 EKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELekfkfvldykiKELKKQIEPRENEIKVMKEQIQEMEAELErfhkq 942
Cdd:TIGR02168  886 EEALALLRSELEELSEELRELESKRSELRRELEEL-----------REKLAQLELRLEGLEVRIDNLQERLSEEY----- 949

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 568929692   943 ntQLELNITELLQKLRATDQEMRKEQQK--ERDLEAL 977
Cdd:TIGR02168  950 --SLTLEEAEALENKIEDDEEEARRRLKrlENKIKEL 984
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 630-1071 1.20e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 65.90  E-value: 1.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   630 LELKTRVEELKME-NEYQLRLKDMNYTEKIKELtdkfiQEMESLKTKNQVlKTEKEKQDISHRERL---EELVDKQTREL 705
Cdd:pfam05483  361 LEELLRTEQQRLEkNEDQLKIITMELQKKSSEL-----EEMTKFKNNKEV-ELEELKKILAEDEKLldeKKQFEKIAEEL 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   706 QDLEccnnQKL--LLEYEKYQ----ELQLKSQRMQEE-YEKQLRD-NDETKSQALE--ELTEFYEAKLQEKTGLLEEAQe 775
Cdd:pfam05483  435 KGKE----QELifLLQAREKEihdlEIQLTAIKTSEEhYLKEVEDlKTELEKEKLKniELTAHCDKLLLENKELTQEAS- 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   776 DVRQQLREFEETKKQIEEDEDREIQDIKTkyerklRDEKESNLRlkGETGIMRKKFSSLQKEIEertndIELLKSEQ--M 853
Cdd:pfam05483  510 DMTLELKKHQEDIINCKKQEERMLKQIEN------LEEKEMNLR--DELESVREEFIQKGDEVK-----CKLDKSEEnaR 576

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   854 KLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNqelekfkfvldykiKELKKQIEPRENEIKVMKEQIQEME 933
Cdd:pfam05483  577 SIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQEN--------------KALKKKGSAENKQLNAYEIKVNKLE 642

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   934 AELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDL--EALVRRFKTDLHnCVAYIQEPGLLKEKIRGLFEKYVQ 1011
Cdd:pfam05483  643 LELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIadEAVKLQKEIDKR-CQHKIAEMVALMEKHKHQYDKIIE 721

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929692  1012 RADmvEIAGLNSDLQQEYARQREHLERNLATLKKKVI---KEGELHRTDYVRI---MQENVSLIKE 1071
Cdd:pfam05483  722 ERD--SELGLYKNKEQEQSSAKAALEIELSNIKAELLslkKQLEIEKEEKEKLkmeAKENTAILKD 785
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 722-985 3.99e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 64.43  E-value: 3.99e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   722 KYQELQlKSQRMQEEYEKQLRDNDETKSQALEELTEFYEaKLQEKTGLLEEAQEdvrqqLREFEETKKQieededrEIQD 801
Cdd:pfam01576   10 KEEELQ-KVKERQQKAESELKELEKKHQQLCEEKNALQE-QLQAETELCAEAEE-----MRARLAARKQ-------ELEE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   802 IKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGL----------KR 871
Cdd:pfam01576   76 ILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLedqnsklskeRK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   872 EIQER-------------------------DETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMK 926
Cdd:pfam01576  156 LLEERiseftsnlaeeeekakslsklknkhEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELR 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568929692   927 EQIQEMEAELE----RFH----------KQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDL 985
Cdd:pfam01576  236 AQLAKKEEELQaalaRLEeetaqknnalKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTEL 308
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
791-1150 4.46e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 4.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  791 IEEDEDRE--------IQDIKTKYERKLRDEKESNLRLKG-ETGIMRKkfSSLQKEIEERTNDIELLKSEQMKLQGIIRS 861
Cdd:PRK03918  141 LESDESREkvvrqilgLDDYENAYKNLGEVIKEIKRRIERlEKFIKRT--ENIEELIKEKEKELEEVLREINEISSELPE 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  862 LEKDIQGLKREIQERDETiqdKEKrIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEaELERFHK 941
Cdd:PRK03918  219 LREELEKLEKEVKELEEL---KEE-IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK-ELKEKAE 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  942 QNTQLElnitELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEpglLKEKIRGLFEKYvqrADMVEIAGL 1021
Cdd:PRK03918  294 EYIKLS----EFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE---LKKKLKELEKRL---EELEERHEL 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1022 NSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLESALKVSKKTRs 1101
Cdd:PRK03918  364 YEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCG- 442

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 568929692 1102 qevpesviskdvvgststmRLNEQEETGRIIEMQRLEIRRLRDQIQEQE 1150
Cdd:PRK03918  443 -------------------RELTEEHRKELLEEYTAELKRIEKELKEIE 472
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
612-1091 4.61e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.91  E-value: 4.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  612 AEEVLvtkTDMEEKAQIMLELKTRVEELKMENEYQLRLKDmNYTEKIKELTDkfiqEMESLKTKNQVLKTEKEKQDIShR 691
Cdd:PRK02224  239 ADEVL---EEHEERREELETLEAEIEDLRETIAETERERE-ELAEEVRDLRE----RLEELEEERDDLLAEAGLDDAD-A 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  692 ERLEELVDKQTRELQDLEccnnqkllleyEKYQELQLKSQRMQEEYEKQLRDNDETKSQAlEELTEfyEAKLQEKTglLE 771
Cdd:PRK02224  310 EAVEARREELEDRDEELR-----------DRLEECRVAAQAHNEEAESLREDADDLEERA-EELRE--EAAELESE--LE 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  772 EAQEDVRQQLREFEETKKQIEEDEDReIQDIKTKYER--KLRDEKESNL-RLKGETGIMRKKFSSLQK------------ 836
Cdd:PRK02224  374 EAREAVEDRREEIEELEEEIEELRER-FGDAPVDLGNaeDFLEELREERdELREREAELEATLRTARErveeaealleag 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  837 ----------------EIEERTNDIELLKSEQMKLQGIIRSLEKDIqglkreiqERDETIQDKEKRIYDLKKKNQELEKf 900
Cdd:PRK02224  453 kcpecgqpvegsphveTIEEDRERVEELEAELEDLEEEVEEVEERL--------ERAEDLVEAEDRIERLEERREDLEE- 523

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  901 kfvldyKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQemRKEQQKERdLEALvRR 980
Cdd:PRK02224  524 ------LIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNS--KLAELKER-IESL-ER 593

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  981 FKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVE-----IAGLNSDLQQ---EYARQ-REHLERNLATLKKKvIKEG 1051
Cdd:PRK02224  594 IRTLLAAIADAEDEIERLREKREALAELNDERRERLAekrerKRELEAEFDEariEEAREdKERAEEYLEQVEEK-LDEL 672

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 568929692 1052 ELHRTDYV-RI-MQENVslIKEINELRRELKLTRSQIYDLES 1091
Cdd:PRK02224  673 REERDDLQaEIgAVENE--LEELEELRERREALENRVEALEA 712
PTZ00121 PTZ00121
MAEBL; Provisional
 603-1079 4.90e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.39  E-value: 4.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  603 IKREREVGFAEEVLVTKTDMEEKAQIMLELKtRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTE 682
Cdd:PTZ00121 1551 LKKAEELKKAEEKKKAEEAKKAEEDKNMALR-KAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  683 KEKQDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQAleeltefYEAK 762
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA-------EEAK 1702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  763 LQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKEsnlrlkgetgimRKKFSSLQKEIEERT 842
Cdd:PTZ00121 1703 KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE------------KKKIAHLKKEEEKKA 1770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  843 NDIELLKSEQMKlqgiirslekdiQGLKREIQERDETIQDKEKRIYDlkkkNQELekfkfvldykIKELKKQIEPRENEI 922
Cdd:PTZ00121 1771 EEIRKEKEAVIE------------EELDEEDEKRRMEVDKKIKDIFD----NFAN----------IIEGGKEGNLVINDS 1824

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  923 KVMkeqiqEMEAELERFHKQNTQLElNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNcvayIQEPGLLKEKI 1002
Cdd:PTZ00121 1825 KEM-----EDSAIKEVADSKNMQLE-EADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEE----IEEADEIEKID 1894

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1003 RGLFEKYVQRADMveiAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELH------RTDYVRIMQENVSLIKEINELR 1076
Cdd:PTZ00121 1895 KDDIEREIPNNNM---AGKNNDIIDDKLDKDEYIKRDAEETREEIIKISKKDmcindfSSKFCDYMKDNISSGNCSDEER 1971


                  ...
gi 568929692 1077 REL 1079
Cdd:PTZ00121 1972 KEL 1974
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 627-1104 5.20e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.98  E-value: 5.20e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   627 QIMLELKTRVEELKMENE--YQLRLKDMNYTEKIKELTDKFIQEMESLKT-KNQVLKTEKEKQD------ISHRERLEEL 697
Cdd:pfam15921  110 QSVIDLQTKLQEMQMERDamADIRRRESQSQEDLRNQLQNTVHELEAAKClKEDMLEDSNTQIEqlrkmmLSHEGVLQEI 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   698 --------------------------------VDKQTRELQ--------------------DLECCNNQKLLLEYEKYQE 725
Cdd:pfam15921  190 rsilvdfeeasgkkiyehdsmstmhfrslgsaISKILRELDteisylkgrifpvedqlealKSESQNKIELLLQQHQDRI 269

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   726 LQLKSQR---------------------------MQEE-------YEKQLRDNDETKSQALEELTE---FYEAKLQEKTG 768
Cdd:pfam15921  270 EQLISEHeveitgltekassarsqansiqsqleiIQEQarnqnsmYMRQLSDLESTVSQLRSELREakrMYEDKIEELEK 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   769 LLEEAQEDV---RQQLREFEETKKQIEEDEDREIQDIKtKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDI 845
Cdd:pfam15921  350 QLVLANSELteaRTERDQFSQESGNLDDQLQKLLADLH-KREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEV 428

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   846 EllkseqmKLQGIIRSLEKDIQGlkrEIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKEL---KKQIEPRENEI 922
Cdd:pfam15921  429 Q-------RLEALLKAMKSECQG---QMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELtakKMTLESSERTV 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   923 KVMKEQIQEMEAELERFHKQNTQLELNITELLQKLratdQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQepgLLKEKI 1002
Cdd:pfam15921  499 SDLTASLQEKERAIEATNAEITKLRSRVDLKLQEL----QHLKNEGDHLRNVQTECEALKLQMAEKDKVIE---ILRQQI 571

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1003 RGLFEKYVQR-----ADMVEIAGLNSDLQ------QEYARQREHLERNLATLKKKViKEGELHRTDYVRIMQENVSLIKE 1071
Cdd:pfam15921  572 ENMTQLVGQHgrtagAMQVEKAQLEKEINdrrlelQEFKILKDKKDAKIRELEARV-SDLELEKVKLVNAGSERLRAVKD 650

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 568929692  1072 I----NELRRELKLTRSQIYDLESALKVSK---KTRSQEV 1104
Cdd:pfam15921  651 IkqerDQLLNEVKTSRNELNSLSEDYEVLKrnfRNKSEEM 690
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
727-979 6.93e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.52  E-value: 6.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  727 QLKSQrMQEEYEKQLRDNDETKSQALEELTEFYEaKLQEKTGLLEEAQEDVRQQLREFEETKKQIE--EDEDREIQDIKT 804
Cdd:PRK02224  191 QLKAQ-IEEKEEKDLHERLNGLESELAELDEEIE-RYEEQREQARETRDEADEVLEEHEERREELEtlEAEIEDLRETIA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  805 KYERKlRDEkesnlrLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKE 884
Cdd:PRK02224  269 ETERE-REE------LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHN 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  885 K-------RIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEaelERFHKQNTQLElNITELLQKL 957
Cdd:PRK02224  342 EeaeslreDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR---ERFGDAPVDLG-NAEDFLEEL 417

                         250       260
                  ....*....|....*....|..
gi 568929692  958 RATDQEMRkeqQKERDLEALVR 979
Cdd:PRK02224  418 REERDELR---EREAELEATLR 436
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 657-1099 2.16e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 2.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   657 KIKELTDKFIQEMESLKTKNQVLK------TEKEKQDISHRERLEELvDKQTRELQDLECCNNQKL--LLEYEKYQELQL 728
Cdd:TIGR04523   34 EEKQLEKKLKTIKNELKNKEKELKnldknlNKDEEKINNSNNKIKIL-EQQIKDLNDKLKKNKDKInkLNSDLSKINSEI 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   729 KSQRMQ--------EEYEKQLRDNDETKSQALEELTefyeaKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDED---R 797
Cdd:TIGR04523  113 KNDKEQknklevelNKLEKQKKENKKNIDKFLTEIK-----KKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLniqK 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   798 EIQDIKTKYERKLRdeKESNLRLKGE-TGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQER 876
Cdd:TIGR04523  188 NIDKIKNKLLKLEL--LLSNLKKKIQkNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKI 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   877 DETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEprENEIKVMKEQIQEMEAELERFHKQNTQLELNITEL--- 953
Cdd:TIGR04523  266 KKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLneq 343

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   954 LQKLRATDQEMRKE-QQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIrglfekyvqradmveiaglnSDLQQEYARQ 1032
Cdd:TIGR04523  344 ISQLKKELTNSESEnSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQI--------------------NDLESKIQNQ 403

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568929692  1033 REhlernLATLKKKVIKEGElhrtdyvrimQENVSLIKEINELRRELKLTRSQIYDLESALKVSKKT 1099
Cdd:TIGR04523  404 EK-----LNQQKDEQIKKLQ----------QEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELI 455
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 828-985 3.05e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldyK 907
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA-------E 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  908 IKELKKQIEP---------RENEIKV-----------------------MKEQIQEMEAELERFHKQNTQLELNITELLQ 955
Cdd:COG4942    99 LEAQKEELAEllralyrlgRQPPLALllspedfldavrrlqylkylapaRREQAEELRADLAELAALRAELEAERAELEA 178

                         170       180       190
                  ....*....|....*....|....*....|
gi 568929692  956 KLRATDQEMRKEQQKERDLEALVRRFKTDL 985
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLARLEKEL 208
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
623-1093 3.20e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.21  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  623 EEKAQIMLELKTRVEElKMENEYQLRLKDMNytEKIKELTDKfIQEMESLKTKNQVLKTEKEKQDISHRERLEelvdkqt 702
Cdd:PRK02224  183 SDQRGSLDQLKAQIEE-KEEKDLHERLNGLE--SELAELDEE-IERYEEQREQARETRDEADEVLEEHEERRE------- 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  703 rELQDLECcnnqklllEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEfyeakLQEKTGLLEEAQEDVRQQLR 782
Cdd:PRK02224  252 -ELETLEA--------EIEDLRETIAETEREREELAEEVRDLRERLEELEEERDD-----LLAEAGLDDADAEAVEARRE 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  783 EFEETKKQIEEDEDREIQDIKTKYERKLRdEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSL 862
Cdd:PRK02224  318 ELEDRDEELRDRLEECRVAAQAHNEEAES-LREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEEL 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  863 EK----------DIQGLKREIQE-RDETIQDKEKRIYDLKKKNQELEKFKFVLDY-KIKELKKQIE--PRENEIKVMKEQ 928
Cdd:PRK02224  397 RErfgdapvdlgNAEDFLEELREeRDELREREAELEATLRTARERVEEAEALLEAgKCPECGQPVEgsPHVETIEEDRER 476

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  929 IQEMEAELERFHKQNTQLELNItELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKI------ 1002
Cdd:PRK02224  477 VEELEAELEDLEEEVEEVEERL-ERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELeaeaee 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1003 -RGLFEKYVQRADMV--EIAGLNSDLqQEYARQREHLERNLATLKKKVIKEGELHRtdyvriMQENVSLIKEINELRRE- 1078
Cdd:PRK02224  556 kREAAAEAEEEAEEAreEVAELNSKL-AELKERIESLERIRTLLAAIADAEDEIER------LREKREALAELNDERREr 628

                         490
                  ....*....|....*
gi 568929692 1079 LKLTRSQIYDLESAL 1093
Cdd:PRK02224  629 LAEKRERKRELEAEF 643
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 724-964 3.64e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.16  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  724 QELQLKSQRMQEEyEKQLRDNDETKSQALEELTEFyEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEdREIQDIK 803
Cdd:COG4942    27 AELEQLQQEIAEL-EKELAALKKEEKALLKQLAAL-ERRIAALARRIRALEQELAALEAELAELEKEIAELR-AELEAQK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  804 TKYERKLRdekesNLRLKGETGIMRKKFSSlqkeieertNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDK 883
Cdd:COG4942   104 EELAELLR-----ALYRLGRQPPLALLLSP---------EDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  884 EKRIYDLKKKNQELEKfkfvldyKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQE 963
Cdd:COG4942   170 EAERAELEALLAELEE-------ERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242


                  .
gi 568929692  964 M 964
Cdd:COG4942   243 T 243
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 859-1098 4.46e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.78  E-value: 4.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  859 IRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldyKIKELKKQIEPRENEIKVMKEQIQEMEAELER 938
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-------RIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  939 FHKQNTQLELNITELLQKL-RATDQEMRKEQQKERDLEALVRRFKTdlhncVAYIQEpgLLKEKIRGLfekyvqRADMVE 1017
Cdd:COG4942    95 LRAELEAQKEELAELLRALyRLGRQPPLALLLSPEDFLDAVRRLQY-----LKYLAP--ARREQAEEL------RADLAE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1018 IAGLNSDLQQEYARQREhLERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLESALKVSK 1097
Cdd:COG4942   162 LAALRAELEAERAELEA-LLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240


                  .
gi 568929692 1098 K 1098
Cdd:COG4942   241 E 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 864-1092 4.91e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.78  E-value: 4.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  864 KDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldyKIKELKKQIEPRENEIKVMKEQIQEMEAELERfhkqn 943
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-------QLAALERRIAALARRIRALEQELAALEAELAE----- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  944 tqLELNITELLQKLratdqemrkEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGL-FEKYVQRADMVEIAGLN 1022
Cdd:COG4942    88 --LEKEIAELRAEL---------EAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLqYLKYLAPARREQAEELR 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1023 SDlQQEYARQREHLERNLATLkKKVIKEGELHRTDYVRIMQENVSLIKeinELRRELKLTRSQIYDLESA 1092
Cdd:COG4942   157 AD-LAELAALRAELEAERAEL-EALLAELEEERAALEALKAERQKLLA---RLEKELAELAAELAELQQE 221
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 613-977 5.49e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 60.52  E-value: 5.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   613 EEVLVTKTDMEEKAQIMLELKTRVEElkmeNEYQLRLKDMNYTeKIKELTDKFIQEMESLKTKNQVLKT-----EKEKQD 687
Cdd:pfam15921  482 EELTAKKMTLESSERTVSDLTASLQE----KERAIEATNAEIT-KLRSRVDLKLQELQHLKNEGDHLRNvqtecEALKLQ 556

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   688 ISHRERLEELVDKQTRELQDLECCNNQKL-LLEYEKYQ-ELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAklqE 765
Cdd:pfam15921  557 MAEKDKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQlEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLEL---E 633

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   766 KTGLLEEAQEDVRQqLREFEETKKQI--EEDEDR-EIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERT 842
Cdd:pfam15921  634 KVKLVNAGSERLRA-VKDIKQERDQLlnEVKTSRnELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTR 712

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   843 NDIELLKSEQ-------MKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQI 915
Cdd:pfam15921  713 NTLKSMEGSDghamkvaMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGEL 792

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   916 EPRENEIKVMKEQIQEMEAELERFHKQNTQLElnitELLQklRATDQEMRKEQQKERDLEAL 977
Cdd:pfam15921  793 EVLRSQERRLKEKVANMEVALDKASLQFAECQ----DIIQ--RQEQESVRLKLQHTLDVKEL 848
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 547-1151 6.33e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.34  E-value: 6.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  547 RAMKYpLSLQKEYNEYQAHAgpvmkmLLTFDDQFLLTvgedgclftWKVFDKDGRGIKREREVgFAEEVLVTKTDMEEKA 626
Cdd:COG1196   211 KAERY-RELKEELKELEAEL------LLLKLRELEAE---------LEELEAELEELEAELEE-LEAELAELEAELEELR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  627 QIMLELKTRVEELKmENEYQLRLKDMNYTEKIKELTDKfIQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQ 706
Cdd:COG1196   274 LELEELELELEEAQ-AEEYELLAELARLEQDIARLEER-RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  707 DLEccnnqkllleyekyqelqlKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEktgllEEAQEDVRQQLREFEE 786
Cdd:COG1196   352 ELE-------------------EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA-----LRAAAELAAQLEELEE 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  787 TKKQIEEDEDREIQDIKTKYERKLRDEKESnlrlkgetgimrkkfSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDI 866
Cdd:COG1196   408 AEEALLERLERLEEELEELEEALAELEEEE---------------EEEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  867 QGLKREIQERDETIQDKEKRIYDLKKKNQELEKFkfvlDYKIKELKKQIEPRE------NEIKVMKEQIQEMEAEL---- 936
Cdd:COG1196   473 ALLEAALAELLEELAEAAARLLLLLEAEADYEGF----LEGVKAALLLAGLRGlagavaVLIGVEAAYEAALEAALaaal 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  937 -ERFHKQNTQLELNITELLQKL--RATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYiqepgllkEKIRGLFEKYVQRA 1013
Cdd:COG1196   549 qNIVVEDDEVAAAAIEYLKAAKagRATFLPLDKIRARAALAAALARGAIGAAVDLVAS--------DLREADARYYVLGD 620

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1014 DMVEIAGLNSDLQQEYARQREHLERNLATLKKkvIKEGELHRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLESAL 1093
Cdd:COG1196   621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLE--GEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEA 698

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692 1094 KVSKKTRSQEvpesviskdvvgsTSTMRLNEQEETGRIIEMQRLEIRRLRDQIQEQEQ 1151
Cdd:COG1196   699 LLAEEEEERE-------------LAEAEEERLEEELEEEALEEQLEAEREELLEELLE 743
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 631-994 6.34e-09

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 59.97  E-value: 6.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  631 ELKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQD--L 708
Cdd:COG5185   150 EASYGEVETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKeiI 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  709 ECCNNQKLLLEYEKYQELqlkSQRMQEEYEKQLRDNDETKsqaleeltefyEAKLQEKTGLLEEAQEDVRQQLREFEETK 788
Cdd:COG5185   230 NIEEALKGFQDPESELED---LAQTSDKLEKLVEQNTDLR-----------LEKLGENAESSKRLNENANNLIKQFENTK 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  789 KQIEEDEDREIQDIKTKYERKLRDEKESN-----LRLKGETGIMR------KKFSSLQKEIEERTNDIELLKSEQMKLQG 857
Cdd:COG5185   296 EKIAEYTKSIDIKKATESLEEQLAAAEAEqeleeSKRETETGIQNltaeieQGQESLTENLEAIKEEIENIVGEVELSKS 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  858 I--IRSLEKDIQGLKREIQERDETIQDKEKRIydlkkkNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAE 935
Cdd:COG5185   376 SeeLDSFKDTIESTKESLDEIPQNQRGYAQEI------LATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISE 449

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568929692  936 LER-FHKQNTQLELNITELLQKLRATDQEMRKEQQKER-DLEALVRRFKTDLHNCVAYIQE 994
Cdd:COG5185   450 LNKvMREADEESQSRLEEAYDEINRSVRSKKEDLNEELtQIESRVSTLKATLEKLRAKLER 510
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
828-1080 6.63e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 60.31  E-value: 6.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKReIQERDETIQD---KEKRIYDLKKKNQELEKFkfvl 904
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQR-LAEYSWDEIDvasAEREIAELEAELERLDAS---- 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  905 DYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQ-------KERDLEAL 977
Cdd:COG4913   684 SDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRalleerfAAALGDAV 763

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  978 VRRFKTDLHNCV-AYIQEPGLLKEKIRGLFEKYVQRADMvEIAGLNSDLQ--QEYAR-----QREHLERNLATLKKKVIK 1049
Cdd:COG4913   764 ERELRENLEERIdALRARLNRAEEELERAMRAFNREWPA-ETADLDADLEslPEYLAlldrlEEDGLPEYEERFKELLNE 842

                         250       260       270
                  ....*....|....*....|....*....|..
gi 568929692 1050 EGELHRTDYVRIMQENVSLIKE-INELRRELK 1080
Cdd:COG4913   843 NSIEFVADLLSKLRRAIREIKErIDPLNDSLK 874
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 605-937 1.14e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 59.35  E-value: 1.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   605 REREVGFAE-EVLVTKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYTEKiKELTDkfiqemeslKTKNQVLKTEK 683
Cdd:pfam05483  448 REKEIHDLEiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLEN-KELTQ---------EASDMTLELKK 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   684 EKQDISHRERLEELVDKQTRELQDLEccNNQKLLLEY------EKYQELQLKSQRMQE-----EYE-------------- 738
Cdd:pfam05483  518 HQEDIINCKKQEERMLKQIENLEEKE--MNLRDELESvreefiQKGDEVKCKLDKSEEnarsiEYEvlkkekqmkilenk 595

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   739 -KQLRDNDETKSQALEELTEfyEAKLQEKTGLLEEAQEDVrqqlREFEETKKQIE-EDEDREIQDIKTKYERKLRDEKES 816
Cdd:pfam05483  596 cNNLKKQIENKNKNIEELHQ--ENKALKKKGSAENKQLNA----YEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKIS 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   817 NLRLKGE---TGIMRKKFSSLQKEIEERTndiellkseQMKLQGIIRSLEKDIQGLKREIQERDEtiqdkEKRIYdlKKK 893
Cdd:pfam05483  670 EEKLLEEvekAKAIADEAVKLQKEIDKRC---------QHKIAEMVALMEKHKHQYDKIIEERDS-----ELGLY--KNK 733

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 568929692   894 NQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELE 937
Cdd:pfam05483  734 EQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAK 777
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
604-949 1.48e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.31  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  604 KREREVgfAEEVLVTKTDMEEKAQIMLELKTRVEELK------------MENEYQLRLKDmNYTEKIKELtDKFIQEMES 671
Cdd:PRK03918  398 KAKEEI--EEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgreLTEEHRKELLE-EYTAELKRI-EKELKEIEE 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  672 LKTKNQVLKTEKEKQDISHRE--RLEELVDkQTRELQD-LECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDndetk 748
Cdd:PRK03918  474 KERKLRKELRELEKVLKKESEliKLKELAE-QLKELEEkLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKE----- 547

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  749 sqaLEELTEFyEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYER--KLRDEKESNLRLKGETGI 826
Cdd:PRK03918  548 ---LEKLEEL-KKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEylELKDAEKELEREEKELKK 623

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  827 MRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRslEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfVLDy 906
Cdd:PRK03918  624 LEEELDKAFEELAETEKRLEELRKELEELEKKYS--EEEYEELREEYLELSRELAGLRAELEELEKRREEIKK---TLE- 697

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 568929692  907 KIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELN 949
Cdd:PRK03918  698 KLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 619-973 1.58e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.96  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   619 KTDMEEKAQIMLELKTRVEElkmeNEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQvLKTEKEKQDishrERLEELV 698
Cdd:pfam05483  218 KEDHEKIQHLEEEYKKEIND----KEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQ-LEEKTKLQD----ENLKELI 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   699 DKQ---TRELQDLECCNNQKLLLEYEKYQELQLKSQ---RMQEEYEKQLRDNDETKSQALEELTEFyeaklQEKTGLLEE 772
Cdd:pfam05483  289 EKKdhlTKELEDIKMSLQRSMSTQKALEEDLQIATKticQLTEEKEAQMEELNKAKAAHSFVVTEF-----EATTCSLEE 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   773 AQEDVRQQLREFEETKKQIEededREIQDIKTKYER--KLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTndiELLKS 850
Cdd:pfam05483  364 LLRTEQQRLEKNEDQLKIIT----MELQKKSSELEEmtKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIA---EELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   851 EQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKK-------KNQELEKFKFVLDYKIKELKKQIEPRENEIK 923
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTelekeklKNIELTAHCDKLLLENKELTQEASDMTLELK 516

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 568929692   924 VMKEQIQEMEAELERFHKQNTQLELNITELLQKLratdQEMRKEQQKERD 973
Cdd:pfam05483  517 KHQEDIINCKKQEERMLKQIENLEEKEMNLRDEL----ESVREEFIQKGD 562
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 645-1149 1.74e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.96  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   645 YQLRLKDMNY--TEKIKELTDKFIQEMESLKtKNQVLKTEKEKQDISHRERLEELVDKQTRELQDLECCNnqkllleyek 722
Cdd:pfam05483   61 YQEGLKDSDFenSEGLSRLYSKLYKEAEKIK-KWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFEN---------- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   723 yQELQLKSQRMQEEYEKQLRDNDETKSqaLEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEET-KKQIEEDEDREIQD 801
Cdd:pfam05483  130 -EKVSLKLEEEIQENKDLIKENNATRH--LCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNiEKMILAFEELRVQA 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   802 IKTKYER--KLRDEKESNLRLKGEtgimrkkfssLQKEIEERTNDIELL------KSEQMK-LQGIIRSLEKDIQGLKRE 872
Cdd:pfam05483  207 ENARLEMhfKLKEDHEKIQHLEEE----------YKKEINDKEKQVSLLliqiteKENKMKdLTFLLEESRDKANQLEEK 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   873 IQERDETIQDKEKRIYDLKKknqELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITE 952
Cdd:pfam05483  277 TKLQDENLKELIEKKDHLTK---ELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTE 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   953 LLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKirglfeKYVQRADMVEIAGLNSDLQQEyARQ 1032
Cdd:pfam05483  354 FEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNN------KEVELEELKKILAEDEKLLDE-KKQ 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1033 REHLERNLATLKKKVI-----KEGELH--RTDYVRIMQENVSLIKEINELRREL---KLTRSQIYDLESALKVSKKTRSQ 1102
Cdd:pfam05483  427 FEKIAEELKGKEQELIfllqaREKEIHdlEIQLTAIKTSEEHYLKEVEDLKTELekeKLKNIELTAHCDKLLLENKELTQ 506

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568929692  1103 EVPESVI-----SKDVVGSTST-MRLNEQEETGRIIEMQ-RLEIRRLRDQIQEQ 1149
Cdd:pfam05483  507 EASDMTLelkkhQEDIINCKKQeERMLKQIENLEEKEMNlRDELESVREEFIQK 560
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
775-1150 2.46e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 58.51  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  775 EDVRQQLRE-FEETKKQIEEDEDREIQDIKTKYERKLRD------EKESNLRLKGETgimRKKFSSLQKEIEERTNDIEL 847
Cdd:PRK02224  179 ERVLSDQRGsLDQLKAQIEEKEEKDLHERLNGLESELAEldeeieRYEEQREQARET---RDEADEVLEEHEERREELET 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  848 LKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKnQELEkfkfvlDYKIKELKKQIEPRENEIKVMKE 927
Cdd:PRK02224  256 LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAE-AGLD------DADAEAVEARREELEDRDEELRD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  928 QIQEMEAELERFHKQNTQLELNITELlqklratDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEpglLKEKIRGLFE 1007
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDL-------EERAEELREEAAELESELEEAREAVEDRREEIEE---LEEEIEELRE 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1008 KY----VQRAdmvEIAGLNSDLQQEYARQREHLERNLATLK--KKVIKEGElhrtdyvRIMQE--------------NVS 1067
Cdd:PRK02224  399 RFgdapVDLG---NAEDFLEELREERDELREREAELEATLRtaRERVEEAE-------ALLEAgkcpecgqpvegspHVE 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1068 LIKE----INELRRELKLTRSQIYDLESALKVSKKTRSQEvpESVISKDVVGSTSTMRLNEQEETgriIEMQRLEIRRLR 1143
Cdd:PRK02224  469 TIEEdrerVEELEAELEDLEEEVEEVEERLERAEDLVEAE--DRIERLEERREDLEELIAERRET---IEEKRERAEELR 543


                  ....*..
gi 568929692 1144 DQIQEQE 1150
Cdd:PRK02224  544 ERAAELE 550
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 640-1042 2.60e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   640 KMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQDLEccNNQKLL-- 717
Cdd:TIGR00606  699 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIE--EQETLLgt 776

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   718 -LEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEF-YEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEeDE 795
Cdd:TIGR00606  777 iMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSdLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQ-DQ 855

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   796 DREIQDIKTKYErKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQgiiRSLEKDIQGLKREIQE 875
Cdd:TIGR00606  856 QEQIQHLKSKTN-ELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLE---TFLEKDQQEKEELISS 931

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   876 RDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELK-KQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITEll 954
Cdd:TIGR00606  932 KETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKdDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDT-- 1009

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   955 QKLRatdQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKirglfEKYVQRADMVEIAGLNSDL----QQEYA 1030
Cdd:TIGR00606 1010 QKIQ---ERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMK-----QEHQKLEENIDLIKRNHVLalgrQKGYE 1081

                          410
                   ....*....|..
gi 568929692  1031 RQREHLERNLAT 1042
Cdd:TIGR00606 1082 KEIKHFKKELRE 1093
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
725-976 2.90e-08

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 56.84  E-value: 2.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  725 ELQLKSQRMQEEYEkQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEdVRQQLREFEETKKQIEEDEDREIQDIKT 804
Cdd:COG1340    12 ELEEKIEELREEIE-ELKEKRDELNEELKELAEKRDELNAQVKELREEAQE-LREKRDELNEKVKELKEERDELNEKLNE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  805 KYE--RKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTndieLLKSEQMKLQGIIRSLEKDIQGLKREIQERDEtIQD 882
Cdd:COG1340    90 LREelDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEV----LSPEEEKELVEKIKELEKELEKAKKALEKNEK-LKE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  883 KEKRIYDLKKKNQELEKfkfvldyKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQ 962
Cdd:COG1340   165 LRAELKELRKEAEEIHK-------KIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQK 237

                         250
                  ....*....|....
gi 568929692  963 EMRKEQQKERDLEA 976
Cdd:COG1340   238 ELRELRKELKKLRK 251
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 717-970 3.05e-08

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 56.74  E-value: 3.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   717 LLEYEKYQELQLKSQRMQEEYEKQLRD------NDETKSQALEELTEFYEAKLQ----EKTGLLEEAQEdVRQQLREF-- 784
Cdd:pfam15905   58 SLELKKKSQKNLKESKDQKELEKEIRAlvqergEQDKRLQALEEELEKVEAKLNaavrEKTSLSASVAS-LEKQLLELtr 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   785 -----------EETKKQIE-------------EDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEE 840
Cdd:pfam15905  137 vnellkakfseDGTQKKMSslsmelmklrnklEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   841 RTNDIELLKSEQMKLQGIIRSLEKdiqgLKREIQERDETiqdkekriydLKKKNQELEKFKFVLDYKIKELKKQIEPREN 920
Cdd:pfam15905  217 EKSETEKLLEYITELSCVSEQVEK----YKLDIAQLEEL----------LKEKNDEIESLKQSLEEKEQELSKQIKDLNE 282

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568929692   921 EIKVMKEQIQEMEAEL-ERFHKQNTQLElnitELLQKLRATDQEMRKEQQK 970
Cdd:pfam15905  283 KCKLLESEKEELLREYeEKEQTLNAELE----ELKEKLTLEEQEHQKLQQK 329
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 744-918 6.53e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.93  E-value: 6.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  744 NDETKSQALEELTEfYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDrEIQDIKTKYERKLRDEKESNLRLKGE 823
Cdd:COG1579     1 AMPEDLRALLDLQE-LDSELDRLEHRLKELPAELAELEDELAALEARLEAAKT-ELEDLEKEIKRLELEIEEVEARIKKY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  824 TGIMR-----KKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRiydLKKKNQELE 898
Cdd:COG1579    79 EEQLGnvrnnKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELE 155

                         170       180
                  ....*....|....*....|
gi 568929692  899 KFKFVLDYKIKELKKQIEPR 918
Cdd:COG1579   156 AELEELEAEREELAAKIPPE 175
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
664-1104 7.71e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.70  E-value: 7.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  664 KFIQEM--ESLKTKNQVLKTEKEKQDISHRERLEELvDKQTRELQDleccnnqklllEYEKYQELQLKSQRMQEEYE--K 739
Cdd:COG4717    41 AFIRAMllERLEKEADELFKPQGRKPELNLKELKEL-EEELKEAEE-----------KEEEYAELQEELEELEEELEelE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  740 QLRDNDETKSQALEELTEFY---------EAKLQEKTGLLEEAQE------DVRQQLREFEETKKQIEEDEDREIQDIKT 804
Cdd:COG4717   109 AELEELREELEKLEKLLQLLplyqelealEAELAELPERLEELEErleelrELEEELEELEAELAELQEELEELLEQLSL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  805 KYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQ-------------------------GII 859
Cdd:COG4717   189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAAleerlkearlllliaaallallglgGSL 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  860 RSLEKDIQGL-------------------KREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEpREN 920
Cdd:COG4717   269 LSLILTIAGVlflvlgllallflllarekASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLD-RIE 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  921 EIKVMKEQIQEMEAELERfhkqnTQLELNITELLQKLRATDQEM-RKEQQKERDLEALVRRFKTdlhncvayiqepglLK 999
Cdd:COG4717   348 ELQELLREAEELEEELQL-----EELEQEIAALLAEAGVEDEEElRAALEQAEEYQELKEELEE--------------LE 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1000 EKIRGLFEKYVQRADMVEIAGLNSDLQQ------EYARQREHLERNLATLKKKvIKEGElHRTDYVRIMQENVSLIKEIN 1073
Cdd:COG4717   409 EQLEELLGELEELLEALDEEELEEELEEleeeleELEEELEELREELAELEAE-LEQLE-EDGELAELLQELEELKAELR 486

                         490       500       510
                  ....*....|....*....|....*....|.
gi 568929692 1074 ELRRELKLTRSQIYDLESALKVSKKTRSQEV 1104
Cdd:COG4717   487 ELAEEWAALKLALELLEEAREEYREERLPPV 517
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 604-1101 7.98e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 7.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   604 KREREVGFAEEVL--VTKTDMEEKAQIMLELKTRVEELKME--------NEYQLRLKDMNYTE-KIKELTDKFIQEMESL 672
Cdd:TIGR02169  262 ELEKRLEEIEQLLeeLNKKIKDLGEEEQLRVKEKIGELEAEiaslersiAEKERELEDAEERLaKLEAEIDKLLAEIEEL 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   673 KTKNQVLKTEKEKQDISHRERLEELVDKQtRELQDLECcNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQAL 752
Cdd:TIGR02169  342 EREIEEERKRRDKLTEEYAELKEELEDLR-AELEEVDK-EFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLS 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   753 EELTEFY------EAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEeDEDREIQDIKTKY---ERKLR------DEKESN 817
Cdd:TIGR02169  420 EELADLNaaiagiEAKINELEEEKEDKALEIKKQEWKLEQLAADLS-KYEQELYDLKEEYdrvEKELSklqrelAEAEAQ 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   818 LRLKGETGIMRKKFSSLQKE--------------IEER------------------TND------IELLKSEQM------ 853
Cdd:TIGR02169  499 ARASEERVRGGRAVEEVLKAsiqgvhgtvaqlgsVGERyataievaagnrlnnvvvEDDavakeaIELLKRRKAgratfl 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   854 -------------------------------------------------------KLQGIIR--SLEKDI---------- 866
Cdd:TIGR02169  579 plnkmrderrdlsilsedgvigfavdlvefdpkyepafkyvfgdtlvvedieaarRLMGKYRmvTLEGELfeksgamtgg 658

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   867 -----------QGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIkvmkeqiQEMEAE 935
Cdd:TIGR02169  659 sraprggilfsRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEI-------EQLEQE 731

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   936 LERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVA-----YIQEPGLLKEKIRGLFEKYV 1010
Cdd:TIGR02169  732 EEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsRIPEIQAELSKLEEEVSRIE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1011 QRADMVEIAGLNSDLQQEYARQ-REHLERNLATLKKKvIKEgelhrtdyvrIMQENVSLIKEINELRRELKLTRSQIYDL 1089
Cdd:TIGR02169  812 ARLREIEQKLNRLTLEKEYLEKeIQELQEQRIDLKEQ-IKS----------IEKEIENLNGKKEELEEELEELEAALRDL 880

                          650
                   ....*....|..
gi 568929692  1090 ESALKVSKKTRS 1101
Cdd:TIGR02169  881 ESRLGDLKKERD 892
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 749-980 8.71e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 8.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  749 SQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEdREIQDIktkyERKLRDekesnlrLKGETGIMR 828
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE-RRIAAL----ARRIRA-------LEQELAALE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  829 KKFSSLQKEIEERTNDIELLKSEqmkLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKI 908
Cdd:COG4942    83 AELAELEKEIAELRAELEAQKEE---LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692  909 KELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRR 980
Cdd:COG4942   160 AELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 627-1150 1.15e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   627 QIMLELKTRVEELKMENEYQLRLKDMNYTEKI------KELTDKFIqEMESLKTKNQVLKTEKEKQdishRERLEELVDK 700
Cdd:pfam15921  381 KLLADLHKREKELSLEKEQNKRLWDRDTGNSItidhlrRELDDRNM-EVQRLEALLKAMKSECQGQ----MERQMAAIQG 455

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   701 QTRELQDLeccnnQKLLLEYEKYQEL------QLKSQRMQ-EEYEKQLRD---NDETKSQALE----ELTEF---YEAKL 763
Cdd:pfam15921  456 KNESLEKV-----SSLTAQLESTKEMlrkvveELTAKKMTlESSERTVSDltaSLQEKERAIEatnaEITKLrsrVDLKL 530

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   764 QEKTGLLEEaQEDVRQQLREFEETKKQIEEdEDREIQDIKTKYE------------------RKLRDEKESN---LRLKg 822
Cdd:pfam15921  531 QELQHLKNE-GDHLRNVQTECEALKLQMAE-KDKVIEILRQQIEnmtqlvgqhgrtagamqvEKAQLEKEINdrrLELQ- 607

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   823 ETGIMRKKFSSLQKEIEERTNDIELLK-------SEQMKLQGIIR------------------SLEKDIQGLKREIQERD 877
Cdd:pfam15921  608 EFKILKDKKDAKIRELEARVSDLELEKvklvnagSERLRAVKDIKqerdqllnevktsrnelnSLSEDYEVLKRNFRNKS 687

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   878 ETIQDKEKRI-YDLKKKNQELEKFKFVLD-------YKIK---ELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQL 946
Cdd:pfam15921  688 EEMETTTNKLkMQLKSAQSELEQTRNTLKsmegsdgHAMKvamGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFL 767

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   947 ELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLlkekirglfeKYVQRADMVEiaglnsdlQ 1026
Cdd:pfam15921  768 KEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASL----------QFAECQDIIQ--------R 829

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1027 QEYARQREHLERNL-------------ATLKKKVIKEGELHRT-DYVRIMQENVSLIKeiNELRRELKLTRSQIYDLESA 1092
Cdd:pfam15921  830 QEQESVRLKLQHTLdvkelqgpgytsnSSMKPRLLQPASFTRThSNVPSSQSTASFLS--HHSRKTNALKEDPTRDLKQL 907

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692  1093 LkvskktrsQEVpesvisKDVVGSTSTMRLNEQEETGRIIEMQRLEiRRLRDQIQEQE 1150
Cdd:pfam15921  908 L--------QEL------RSVINEEPTVQLSKAEDKGRAPSLGALD-DRVRDCIIESS 950
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 601-901 1.29e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.90  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   601 RGIKREREVGFAEEVlvTKTDMEEKAQIMLELktrvEELKMENEYQLrlkdmnytEKIKELTDKfiQEMESLKTKNQVLK 680
Cdd:pfam17380  310 REVERRRKLEEAEKA--RQAEMDRQAAIYAEQ----ERMAMEREREL--------ERIRQEERK--RELERIRQEEIAME 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   681 TEKekqdISHRERLE-ELVDKQTRELQDLECCNNQKLLLEyekyqELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFY 759
Cdd:pfam17380  374 ISR----MRELERLQmERQQKNERVRQELEAARKVKILEE-----ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEER 444

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   760 EAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKfSSLQKEIE 839
Cdd:pfam17380  445 AREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKR-KLLEKEME 523

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   840 ERTNDIelLKSEQMKLQGIIRSLEKDIQGlKREIQERDETIQDKEKRIYDLKKKNQELEKFK 901
Cdd:pfam17380  524 ERQKAI--YEEERRREAEEERRKQQEMEE-RRRIQEQMRKATEERSRLEAMEREREMMRQIV 582
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
770-913 1.42e-07

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 55.63  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  770 LEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKEsnlRLKGETGIMRKKFSSLQKEIEERTNDIELLK 849
Cdd:COG2433   378 IEEALEELIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVE---RLEAEVEELEAELEEKDERIERLERELSEAR 454

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568929692  850 SEQmklqgiIRSLEKDiqglkREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldyKIKELKK 913
Cdd:COG2433   455 SEE------RREIRKD-----REISRLDREIERLERELEEERERIEELKR-------KLERLKE 500
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
741-983 1.53e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.79  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  741 LRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQedvrQQLREFEETKKQIEededreiqdiktkyerklrdekesnlrL 820
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEEAE----AALEEFRQKNGLVD---------------------------L 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  821 KGETGIMRKKFSSLQKEIEErtndielLKSEQMKLQGIIRSLEKDIQGLKREIQE--RDETIQDKEKRIYDLKKKNQELE 898
Cdd:COG3206   211 SEEAKLLLQQLSELESQLAE-------ARAELAEAEARLAALRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELS 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  899 KfKFVLDY-KIKELKKQIEPRENEIKVMKEQI-QEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEA 976
Cdd:COG3206   284 A-RYTPNHpDVIALRAQIAALRAQLQQEAQRIlASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEV 362


                  ....*..
gi 568929692  977 LVRRFKT 983
Cdd:COG3206   363 ARELYES 369
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 621-921 1.65e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.84  E-value: 1.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   621 DMEEKAQIMLELKTRVEELKMENE-YQLRLKDMNytEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELVD 699
Cdd:TIGR02169  731 EEEKLKERLEELEEDLSSLEQEIEnVKSELKELE--ARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVS 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   700 KQTRELQDLEccnnqkllleyEKYQELQLKSQRMQEEYEKQLRDNDETKSQ--ALEELTEFYEAKLQEKTGLLEEAQEDV 777
Cdd:TIGR02169  809 RIEARLREIE-----------QKLNRLTLEKEYLEKEIQELQEQRIDLKEQikSIEKEIENLNGKKEELEEELEELEAAL 877

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   778 RQQLREFEETKKQIEEDED--REIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQmKL 855
Cdd:TIGR02169  878 RDLESRLGDLKKERDELEAqlRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLE-DV 956

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   856 QGIIRSLEKDIQGLK----REIQERDETiqdkEKRIYDLKKKNQELEKFKfvldykiKELKKQIEPRENE 921
Cdd:TIGR02169  957 QAELQRVEEEIRALEpvnmLAIQEYEEV----LKRLDELKEKRAKLEEER-------KAILERIEEYEKK 1015
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 620-1151 1.79e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 55.75  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   620 TDMEEKAQIMLELKTRVEELKM----ENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDIS------ 689
Cdd:TIGR00618  216 TYHERKQVLEKELKHLREALQQtqqsHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRArkaapl 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   690 --HRERLEELVDKQTRELQDLECCNNqKLLLEYEKYQELQLKSQRMQEEY--EKQLRDNDETKSQALEELTEFYEAKLQE 765
Cdd:TIGR00618  296 aaHIKAVTQIEQQAQRIHTELQSKMR-SRAKLLMKRAAHVKQQSSIEEQRrlLQTLHSQEIHIRDAHEVATSIREISCQQ 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   766 KTGLLE-EAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKlRDEKESNLRLKGETGIMRKKFSSLQKEIEERTND 844
Cdd:TIGR00618  375 HTLTQHiHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAF-RDLQGQLAHAKKQQELQQRYAELCAAAITCTAQC 453

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   845 IELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKF--------------------VL 904
Cdd:TIGR00618  454 EKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIhpnparqdidnpgpltrrmqRG 533

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   905 DYKIKELKKQIEPRE-------NEIKVMKEQIQEMEAELERFhkqnTQLELNITELLQKLRATDQEMRKEQQKERDLEal 977
Cdd:TIGR00618  534 EQTYAQLETSEEDVYhqltserKQRASLKEQMQEIQQSFSIL----TQCDNRSKEDIPNLQNITVRLQDLTEKLSEAE-- 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   978 vrrfktdlhncvayIQEPGLLKEKIRGLFEKyvqrADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTD 1057
Cdd:TIGR00618  608 --------------DMLACEQHALLRKLQPE----QDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRV 669

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1058 yvrimQENVSLIKEINELRRELKLTRSQIYDLESALKVSKKTRSQEVPESVISKDV-----VGSTSTMRLNEQEETGR-- 1130
Cdd:TIGR00618  670 -----LPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFneienASSSLGSDLAAREDALNqs 744

                          570       580
                   ....*....|....*....|.
gi 568929692  1131 IIEMQRLEIRRLRDQIQEQEQ 1151
Cdd:TIGR00618  745 LKELMHQARTVLKARTEAHFN 765
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 619-1014 1.90e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 55.60  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   619 KTDMEEKAQIMLELKTRVEELKMENEyqlrlKDMNYTEKIKEltdkfiqemeSLKTKNQ---VLKTEKEkqdiSHRERLE 695
Cdd:pfam10174  295 KQELSKKESELLALQTKLETLTNQNS-----DCKQHIEVLKE----------SLTAKEQraaILQTEVD----ALRLRLE 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   696 E---LVDKQTRELQDLeccNNQKLLLEYE-------------KYQELQLKSQRMQEeyekQLRDNDetksQALEELTEFY 759
Cdd:pfam10174  356 EkesFLNKKTKQLQDL---TEEKSTLAGEirdlkdmldvkerKINVLQKKIENLQE----QLRDKD----KQLAGLKERV 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   760 EAkLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREiqdiktkyERKLRDEKESnlrLKGETGIMRKKFSSLQKEIE 839
Cdd:pfam10174  425 KS-LQTDSSNTDTALTTLEEALSEKERIIERLKEQRERE--------DRERLEELES---LKKENKDLKEKVSALQPELT 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   840 ERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIydlkKKNQELEkfkfvLDYKIK-ELKKQIEPR 918
Cdd:pfam10174  493 EKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQL----KKAHNAE-----EAVRTNpEINDRIRLL 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   919 ENEIKVMKEQIQEMEAELERfhkqntqlelniteLLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQE-PGL 997
Cdd:pfam10174  564 EQEVARYKEESGKAQAEVER--------------LLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHgQQE 629

                          410
                   ....*....|....*..
gi 568929692   998 LKEKIRGLFEKYVQRAD 1014
Cdd:pfam10174  630 MKKKGAQLLEEARRRED 646
WD40 COG2319
WD40 repeat [General function prediction only];
385-597 3.24e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  385 PLHSASITGLDTCIRKPLIATCSLDRSVRIWNYESN-TLELYKEYQEEAYTVSLHPSGHYIVVGFADKlrlmnlliddir 463
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGlLLRTLTGHTGAVRSVAFSPDGKTLASGSADG------------ 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  464 pfkeysvrgckecsfsngghlfaavngnVIHIFTTTSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSV 543
Cdd:COG2319   143 ----------------------------TVRLWDLATGKLLRTLTGHSGAV-----------TSVAFSPDGKLLASGSDD 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568929692  544 GTIRAmkYPLSLQKEYNEYQAHAGPVMKMLLTFDDQFLLTVGEDGclfTWKVFD 597
Cdd:COG2319   184 GTVRL--WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG---TVRLWD 232
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 604-1086 4.63e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  604 KREREVGFAEEVLVTKTDMEEKAQIMLELKTRVEELKMENEyQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEK 683
Cdd:COG1196   286 AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA-ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  684 EKQD------ISHRERLEELVDKQTRELQDLEccNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTE 757
Cdd:COG1196   365 EALLeaeaelAEAEEELEELAEELLEALRAAA--ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEE 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  758 FYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKE 837
Cdd:COG1196   443 ALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  838 IE--------ERTNDIELLKSEQMKLQGIIRSLEKD----IQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLD 905
Cdd:COG1196   523 AGavavligvEAAYEAALEAALAAALQNIVVEDDEVaaaaIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVD 602

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  906 YKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRfktdl 985
Cdd:COG1196   603 LVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEA----- 677

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  986 hncvayIQEPGLLKEKIRGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRIMQEN 1065
Cdd:COG1196   678 ------EAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEE 751

                         490       500
                  ....*....|....*....|....*
gi 568929692 1066 VSLIKE----INELRRELKLTRSQI 1086
Cdd:COG1196   752 ALEELPeppdLEELERELERLEREI 776
PTZ00121 PTZ00121
MAEBL; Provisional
 606-1152 5.40e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.38  E-value: 5.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  606 EREVGFAEEVLVTKTDMEEKAQIMLELKTRVEELKMENEYQlRLKDMNYTEKIKELTDKFIQEM----------ESLKTK 675
Cdd:PTZ00121 1094 EEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEAR-KAEDARKAEEARKAEDAKRVEIarkaedarkaEEARKA 1172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  676 NQVLKTEKEKQDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKYQELQL-----KSQRMQEEYEKQLRDNDETKSQ 750
Cdd:PTZ00121 1173 EDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKaeavkKAEEAKKDAEEAKKAEEERNNE 1252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  751 ALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIE---EDEDREIQDIKTKYERKlrdEKESNLRLKGETGim 827
Cdd:PTZ00121 1253 EIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEakkAEEKKKADEAKKKAEEA---KKADEAKKKAEEA-- 1327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQErdetiqdKEKRIYDLKKKNQELEkfkfvldyK 907
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEE-------AKKKADAAKKKAEEKK--------K 1392

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  908 IKELKKQIEprenEIKVMKEQIQEMEAELERFHKQNTQLElnitellQKLRATDQEMRKEQQKERDLEALVRRFKTDLHN 987
Cdd:PTZ00121 1393 ADEAKKKAE----EDKKKADELKKAAAAKKKADEAKKKAE-------EKKKADEAKKKAEEAKKADEAKKKAEEAKKAEE 1461

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  988 CVAYIQEPGLLKEKIRGLFEKyvQRADMVEIAGLNSDLQQEYARQREHLERNLATLKK--KVIKEGELHRTDYVRIMQE- 1064
Cdd:PTZ00121 1462 AKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaeEAKKADEAKKAEEAKKADEa 1539

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1065 -NVSLIKEINELRRELKLTRSqiydlESALKVSKKTRSQEVPESVISK-------DVVGSTSTMRLNEQEETGRIIEMQR 1136
Cdd:PTZ00121 1540 kKAEEKKKADELKKAEELKKA-----EEKKKAEEAKKAEEDKNMALRKaeeakkaEEARIEEVMKLYEEEKKMKAEEAKK 1614

                         570
                  ....*....|....*..
gi 568929692 1137 LEIRRLR-DQIQEQEQV 1152
Cdd:PTZ00121 1615 AEEAKIKaEELKKAEEE 1631
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
828-983 6.11e-07

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 53.71  E-value: 6.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  828 RKKFSSLQKEIEERTnDIELLKSEQMK---LQGIIRSLEKDIQGLK-----REIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:COG2433   349 KNKFERVEKKVPPDV-DRDEVKARVIRglsIEEALEELIEKELPEEepeaeREKEHEERELTEEEEEIRRLEEQVERLEA 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  900 FKFVLDYKIKELKKQIEPRENEIKVMKeqiQEMEAELERfHKQNTQLElNITELLQKlratdqEMRKEQQKERDLEALVR 979
Cdd:COG2433   428 EVEELEAELEEKDERIERLERELSEAR---SEERREIRK-DREISRLD-REIERLER------ELEEERERIEELKRKLE 496


                  ....
gi 568929692  980 RFKT 983
Cdd:COG2433   497 RLKE 500
COG5022 COG5022
Myosin heavy chain [General function prediction only];
653-1057 6.12e-07

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 53.93  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  653 NYTEKIKELTDKFIQEMESLKTKNQVLKT----EKEKQDISHRERLEEL-VDKQTRELqdLECCNNqkllLEYEKYQELQ 727
Cdd:COG5022   758 RYLRRRYLQALKRIKKIQVIQHGFRLRRLvdyeLKWRLFIKLQPLLSLLgSRKEYRSY--LACIIK----LQKTIKREKK 831

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  728 LKSqrmqeeyekqlRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEE--DEDREIQDIKTK 805
Cdd:COG5022   832 LRE-----------TEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQLQElkIDVKSISSLKLV 900

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  806 YER------KLRDEKESNLRLKGEtgIMRKKFSSLQKEIEERtnDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDET 879
Cdd:COG5022   901 NLEleseiiELKKSLSSDLIENLE--FKTELIARLKKLLNNI--DLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDL 976

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  880 IQDKEKRIYDLKKKNQELEKFKfvldykiKELkkqiepreNEIKVMKEQIQEMEAELERFHKQNTQLElNITELLQKLRA 959
Cdd:COG5022   977 LKKSTILVREGNKANSELKNFK-------KEL--------AELSKQYGALQESTKQLKELPVEVAELQ-SASKIISSEST 1040

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  960 TDQEMRKEQQKERDLEALVRRFKTDLHNcVAYIQEPGLLKEKirglfEKYVQRADMVEIAGLNSDLQQEYARQREHLERN 1039
Cdd:COG5022  1041 ELSILKPLQKLKGLLLLENNQLQARYKA-LKLRRENSLLDDK-----QLYQLESTENLLKTINVKDLEVTNRNLVKPANV 1114

                         410
                  ....*....|....*...
gi 568929692 1040 LATLKKKVIKEGELHRTD 1057
Cdd:COG5022  1115 LQFIVAQMIKLNLLQEIS 1132
PRK12704 PRK12704
phosphodiesterase; Provisional
 835-938 6.92e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 53.24  E-value: 6.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  835 QKEIEERTNDIEL-LKSEQMKLQgiiRSLEKDIQGLKREIQERDETIQDKEKRiydLKKKNQELEKFKFVLDYKIKELKK 913
Cdd:PRK12704   48 KKEAEAIKKEALLeAKEEIHKLR---NEFEKELRERRNELQKLEKRLLQKEEN---LDRKLELLEKREEELEKKEKELEQ 121

                          90       100
                  ....*....|....*....|....*
gi 568929692  914 QIEPRENEIKVMKEQIQEMEAELER 938
Cdd:PRK12704  122 KQQELEKKEEELEELIEEQLQELER 146
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 658-987 9.60e-07

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 52.93  E-value: 9.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   658 IKELTDK--FIQEMESLKTKNQVLK-TEKEKQDIshRERLEELVDKQTR---ELQDLEccnnqkllleyEKYQELQ--LK 729
Cdd:pfam06160   72 AEELNDKyrFKKAKKALDEIEELLDdIEEDIKQI--LEELDELLESEEKnreEVEELK-----------DKYRELRktLL 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   730 SQRMQ-----EEYEKQLrDNDETKSQALEELTE---FYEAK------------LQEKT----GLLEEAQEDVRQQLREFE 785
Cdd:pfam06160  139 ANRFSygpaiDELEKQL-AEIEEEFSQFEELTEsgdYLEARevlekleeetdaLEELMedipPLYEELKTELPDQLEELK 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   786 ETKKQIEEDE--------DREIQDIKTKYERKLrdEKESNLRLKGetgiMRKKFSSLQKEIEERTNDIEL-LKSEQ--MK 854
Cdd:pfam06160  218 EGYREMEEEGyalehlnvDKEIQQLEEQLEENL--ALLENLELDE----AEEALEEIEERIDQLYDLLEKeVDAKKyvEK 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   855 LQGIIRSLEKDIQGLKREIQERDETIQDKekriYDLkkKNQELEKFKfVLDYKIKELKKQIEPRENEIKVMKEQIQEMEA 934
Cdd:pfam06160  292 NLPEIEDYLEHAEEQNKELKEELERVQQS----YTL--NENELERVR-GLEKQLEELEKRYDEIVERLEEKEVAYSELQE 364

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568929692   935 ELERFHKQNTQLELNITELLQKLratdQEMRKEQQKERDleaLVRRFKTDLHN 987
Cdd:pfam06160  365 ELEEILEQLEEIEEEQEEFKESL----QSLRKDELEARE---KLDEFKLELRE 410
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
904-1103 9.63e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 53.10  E-value: 9.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  904 LDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQN--TQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRF 981
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAAL 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  982 KTDL---HNCVAYIQEPGLLKEKIRGLFEKYVQRADMV---------------EIAGLNSDLQQEYARQREHLERNLATL 1043
Cdd:COG3206   246 RAQLgsgPDALPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvialraQIAALRAQLQQEAQRILASLEAELEAL 325

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692 1044 KKkviKEGELHRT--DYVRIMQENVSLIKEINELRRELKLTRSQiydLESALKVSKKTRSQE 1103
Cdd:COG3206   326 QA---REASLQAQlaQLEARLAELPELEAELRRLEREVEVAREL---YESLLQRLEEARLAE 381
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 839-1151 1.00e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 52.98  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   839 EERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPR 918
Cdd:pfam07888   55 RQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIREL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   919 ENEIKVMKEQIQEMEAELERF-------HKQNTQLELNITELLQKLRATDQEMR---------KEQQKERDLEAL----- 977
Cdd:pfam07888  135 EEDIKTLTQRVLERETELERMkerakkaGAQRKEEEAERKQLQAKLQQTEEELRslskefqelRNSLAQRDTQVLqlqdt 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   978 VRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVEiaGLNSDLqQEYARQREH---------LERNLATLK---- 1044
Cdd:pfam07888  215 ITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVE--GLGEEL-SSMAAQRDRtqaelhqarLQAAQLTLQlada 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1045 KKVIKEGELHRTDYVRIMQENVSLIKEinelrRELKLTRsQIYDLESALKVSKKTRSQEVPESVISKD---VVGSTSTMR 1121
Cdd:pfam07888  292 SLALREGRARWAQERETLQQSAEADKD-----RIEKLSA-ELQRLEERLQEERMEREKLEVELGREKDcnrVQLSESRRE 365

                          330       340       350
                   ....*....|....*....|....*....|....
gi 568929692  1122 LNEQEETGRII----EMQRLEIRRLRDQIQEQEQ 1151
Cdd:pfam07888  366 LQELKASLRVAqkekEQLQAEKQELLEYIRQLEQ 399
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 723-1141 1.29e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.92  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   723 YQELQLKSQRMQEEYEKQLRDndetKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFE--ETKKQIEEDEDREIQ 800
Cdd:pfam12128  267 YKSDETLIASRQEERQETSAE----LNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEalEDQHGAFLDADIETA 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   801 DIKTKYERKLRDEKES-NLRLKGETGIMRK---KFSSLQKEIEERTN-DIELLKSEQMKL-QGIIRSL---EKDIQGLKR 871
Cdd:pfam12128  343 AADQEQLPSWQSELENlEERLKALTGKHQDvtaKYNRRRSKIKEQNNrDIAGIKDKLAKIrEARDRQLavaEDDLQALES 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   872 EIQERDET----IQDKEKRIydlkkkNQELEKFKFVLDYKI--KELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQ 945
Cdd:pfam12128  423 ELREQLEAgkleFNEEEYRL------KSRLGELKLRLNQATatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQ 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   946 LELNITELLQKLRatDQEMRKEQQKERdLEALVRRFKTDLHNCVAYIQ-EPGLLKEKIRGL-------------FEKYVQ 1011
Cdd:pfam12128  497 ARKRRDQASEALR--QASRRLEERQSA-LDELELQLFPQAGTLLHFLRkEAPDWEQSIGKVispellhrtdldpEVWDGS 573

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1012 RADMVEIAGLNSDLQQ----EYARQREHLERNLATLKKKVIKEGELHRtdyvRIMQENVSLIKEINELRRELKLTRS--- 1084
Cdd:pfam12128  574 VGGELNLYGVKLDLKRidvpEWAASEEELRERLDKAEEALQSAREKQA----AAEEQLVQANGELEKASREETFARTalk 649

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692  1085 -------QIYDLESALKVSK----KTRSQEVPESVIS----KDVVGSTSTMRLNEQEETGRIIEMQRLEIRR 1141
Cdd:pfam12128  650 narldlrRLFDEKQSEKDKKnkalAERKDSANERLNSleaqLKQLDKKHQAWLEEQKEQKREARTEKQAYWQ 721
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 747-1086 1.29e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.13  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   747 TKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEdEDREIQDIKTKYERK------LRDEKESNLRL 820
Cdd:TIGR00606  709 DKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQK-VNRDIQRLKNDIEEQetllgtIMPEEESAKVC 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   821 KGETGIMRKkfssLQKEIEERTNDIELLKSeqmKLQGIirSLEKDIQGLKREIQERDET--------------IQDKEKR 886
Cdd:TIGR00606  788 LTDVTIMER----FQMELKDVERKIAQQAA---KLQGS--DLDRTVQQVNQEKQEKQHEldtvvskielnrklIQDQQEQ 858

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   887 IYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRK 966
Cdd:TIGR00606  859 IQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKK 938

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   967 EQQKERDLealvrrfKTDLHNCVAYIQEpglLKEKIRGLFEKYVQRADmVEIAGLNSDLqQEYARQREHLERNLATLKKK 1046
Cdd:TIGR00606  939 AQDKVNDI-------KEKVKNIHGYMKD---IENKIQDGKDDYLKQKE-TELNTVNAQL-EECEKHQEKINEDMRLMRQD 1006

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 568929692  1047 VIKEGELHrtdyvRIMQENVSLIK---EINELRRELKLTRSQI 1086
Cdd:TIGR00606 1007 IDTQKIQE-----RWLQDNLTLRKrenELKEVEEELKQHLKEM 1044
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
668-961 3.21e-06

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 50.29  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  668 EMESLKTKNQVLKTEKEKqdisHRERLEELVdKQTRELQdleccnnQKLLLEYEKYQELQLKSQRMQEEYE---KQLRDN 744
Cdd:COG1340     9 SLEELEEKIEELREEIEE----LKEKRDELN-EELKELA-------EKRDELNAQVKELREEAQELREKRDelnEKVKEL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  745 DETKSQALEELTEFYEaKLQEKTGLLEEAQEDVRqqlrEFEETKKQIEEDEDR-EIQDIKTKYERKLRDEKESnlrlkge 823
Cdd:COG1340    77 KEERDELNEKLNELRE-ELDELRKELAELNKAGG----SIDKLRKEIERLEWRqQTEVLSPEEEKELVEKIKE------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  824 tgiMRKKFSSLQKEIEERtNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfv 903
Cdd:COG1340   145 ---LEKELEKAKKALEKN-EKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHK---- 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692  904 ldyKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATD 961
Cdd:COG1340   217 ---EIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAEE 271
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
646-1009 3.36e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  646 QLRLKDMNYTEKIKELtDKFIQEMESLKTKNQVLKTEKEK--QDISHRERLEELVDKQtRELQDLECCNnQKLLLEYEKY 723
Cdd:COG4717    82 EAEEKEEEYAELQEEL-EELEEELEELEAELEELREELEKleKLLQLLPLYQELEALE-AELAELPERL-EELEERLEEL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  724 QELQLKSQRMQEEYEK-------QLRDNDETKSQALEELTEFYEAklqektglLEEAQEDVRQQLREFEETKKQIEEDED 796
Cdd:COG4717   159 RELEEELEELEAELAElqeeleeLLEQLSLATEEELQDLAEELEE--------LQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  797 R-EIQDIKTKYERKLRDEK--------------------ESNLRLKG-----------ETGIMRKKFSSLQKEIEERTND 844
Cdd:COG4717   231 QlENELEAAALEERLKEARlllliaaallallglggsllSLILTIAGvlflvlgllalLFLLLAREKASLGKEAEELQAL 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  845 IELLKSEQMKLQGI--------------IRSLEKDIQGLKREIQERDEtiQDKEKRIYDLKKKNQELEKFKFVLD----Y 906
Cdd:COG4717   311 PALEELEEEELEELlaalglppdlspeeLLELLDRIEELQELLREAEE--LEEELQLEELEQEIAALLAEAGVEDeeelR 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  907 KIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNT--QLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTD 984
Cdd:COG4717   389 AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDeeELEEELEELEEELEELEEELEELREELAELEAELEQLEED 468

                         410       420
                  ....*....|....*....|....*
gi 568929692  985 lHNCVAYIQEPGLLKEKIRGLFEKY 1009
Cdd:COG4717   469 -GELAELLQELEELKAELRELAEEW 492
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 734-971 3.56e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.60  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  734 QEEYEKQLRDNDETKSQALEELTEfYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEdREIQDIKTKYERKLRDE 813
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDA-LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE-AEIEERREELGERARAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  814 KESNlrlkGETGIMRKKFSSlqKEIEERTNDIELLKSEQMKLQGIIRSLEKDiqglKREIQERDETIQDKEKriyDLKKK 893
Cdd:COG3883    96 YRSG----GSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKAD----KAELEAKKAELEAKLA---ELEAL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692  894 NQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKE 971
Cdd:COG3883   163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 240
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
762-1098 3.82e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 50.67  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  762 KLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKEsnlrlkgetgiMRKKFSSLQKEIEER 841
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQ-----------AREELEQLEEELEQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  842 TNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENE 921
Cdd:COG4372    72 RSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  922 IKVMKEQIQEMEAELERFhkQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEK 1001
Cdd:COG4372   152 LKELEEQLESLQEELAAL--EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1002 IRGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINELRRELKL 1081
Cdd:COG4372   230 KLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSL 309

                         330
                  ....*....|....*..
gi 568929692 1082 TRSQIYDLESALKVSKK 1098
Cdd:COG4372   310 IGALEDALLAALLELAK 326
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 667-899 7.88e-06

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 49.18  E-value: 7.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   667 QEMESLKTKNQVLKTEKEK------QDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQ 740
Cdd:pfam09728   39 KDLKKLKKKQDQLQKEKDQlqselsKAILAKSKLEKLCRELQKQNKKLKEESKKLAKEEEEKRKELSEKFQSTLKDIQDK 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   741 LRDNDETKSQALEELTEFYE--AKLQEKTGLLEE------AQEDVRQQLRE------FEETKKQIEEDEDREIQDIKTKY 806
Cdd:pfam09728  119 MEEKSEKNNKLREENEELREklKSLIEQYELRELhfekllKTKELEVQLAEaklqqaTEEEEKKAQEKEVAKARELKAQV 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   807 ERKLRDEKEsnlrLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETI------ 880
Cdd:pfam09728  199 QTLSETEKE----LREQLNLYVEKFEEFQDTLNKSNEVFTTFKKEMEKMSKKIKKLEKENLTWKRKWEKSNKALlemaee 274

                          250       260
                   ....*....|....*....|
gi 568929692   881 -QDKEKRIYDLKKKNQELEK 899
Cdd:pfam09728  275 rQKLKEELEKLQKKLEKLEN 294
COG5022 COG5022
Myosin heavy chain [General function prediction only];
614-985 8.41e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.46  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  614 EVLVTKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYtEKIKELTDkFIQEMESLKTKNQVLKTEkekqdisHRER 693
Cdd:COG5022   862 SLLKKETIYLQSAQRVELAERQLQELKIDVKSISSLKLVNL-ELESEIIE-LKKSLSSDLIENLEFKTE-------LIAR 932

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  694 LEELVDKQTRELQdleccnnqkLLLEYEKYQELqlksQRMQEEyEKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEA 773
Cdd:COG5022   933 LKKLLNNIDLEEG---------PSIEYVKLPEL----NKLHEV-ESKLKETSEEYEDLLKKSTILVREGNKANSELKNFK 998

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  774 QE--DVRQQLREFEETKKQIEEdEDREIQDIKTKYeRKLRDEKESNLRLKGETGIMR---KKFSSLQKEIEERTNDIE-- 846
Cdd:COG5022   999 KElaELSKQYGALQESTKQLKE-LPVEVAELQSAS-KIISSESTELSILKPLQKLKGlllLENNQLQARYKALKLRREns 1076

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  847 LLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKN----QELEKFKFVLDYKIKELKKQIEPRENEI 922
Cdd:COG5022  1077 LLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKPANVLQFIVAQMIKlnllQEISKFLSQLVNTLEPVFQKLSVLQLEL 1156

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568929692  923 KVMKEQIQ-EMEAELERFHKQNTQLELNITELLQKLRATDQEMrkeQQKERDLEALVRRFKTDL 985
Cdd:COG5022  1157 DGLFWEANlEALPSPPPFAALSEKRLYQSALYDEKSKLSSSEV---NDLKNELIALFSKIFSGW 1217
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
755-1085 8.67e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 8.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  755 LTEFYEAKLQEKtgLLEEAQEDVRQQLREFEETKKQIEEDEdREIQDIKTKYE--RKLRDEKESnlrlkgetgiMRKKFS 832
Cdd:COG4717    39 LLAFIRAMLLER--LEKEADELFKPQGRKPELNLKELKELE-EELKEAEEKEEeyAELQEELEE----------LEEELE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  833 SLQKEIEERTNDIELLK---------SEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKfkfV 903
Cdd:COG4717   106 ELEAELEELREELEKLEkllqllplyQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEE---L 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  904 LDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKE--RDLEALVRRF 981
Cdd:COG4717   183 LEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLllLIAAALLALL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  982 KTDLHNCVAYIQEPGLLKEKIrGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLE-RNLATLKKKVIKEGELHRT---D 1057
Cdd:COG4717   263 GLGGSLLSLILTIAGVLFLVL-GLLALLFLLLAREKASLGKEAEELQALPALEELEeEELEELLAALGLPPDLSPEellE 341

                         330       340
                  ....*....|....*....|....*...
gi 568929692 1058 YVRIMQENVSLIKEINELRRELKLTRSQ 1085
Cdd:COG4717   342 LLDRIEELQELLREAEELEEELQLEELE 369
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 744-941 9.38e-06

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 48.91  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  744 NDETKSQALEELTEFYEAKLQEKTGLLEEAQEdVRQQLREFEetkKQIEEDEDrEIQDIKTKYERKLRDEKESnlrlkge 823
Cdd:cd22656   108 DDEELEEAKKTIKALLDDLLKEAKKYQDKAAK-VVDKLTDFE---NQTEKDQT-ALETLEKALKDLLTDEGGA------- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  824 tgIMRKKFSSLQKEIEErtndiellkseqmKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKknqelekfkfv 903
Cdd:cd22656   176 --IARKEIKDLQKELEK-------------LNEEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTA----------- 229

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568929692  904 LDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHK 941
Cdd:cd22656   230 ADTDLDNLLALIGPAIPALEKLQGAWQAIATDLDSLKD 267
COG5022 COG5022
Myosin heavy chain [General function prediction only];
635-1117 9.38e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.08  E-value: 9.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  635 RVEELKMENEYQLRLKDMNYTEKIKELTDKfiqEMESLKTKNQVLKTEKEKQDIShrERLEELVDKQT---RELQDlecc 711
Cdd:COG5022   919 LIENLEFKTELIARLKKLLNNIDLEEGPSI---EYVKLPELNKLHEVESKLKETS--EEYEDLLKKSTilvREGNK---- 989

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  712 NNQKLLLEYEKYQELQLKSQRMQEEyEKQLRDNDeTKSQALEELTEFY---------EAKLQEKTGLLEEAQEDVRQQLR 782
Cdd:COG5022   990 ANSELKNFKKELAELSKQYGALQES-TKQLKELP-VEVAELQSASKIIssestelsiLKPLQKLKGLLLLENNQLQARYK 1067

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  783 EFEETKKQIEEDEDREIQDIKTKYERK---LRDEKESNLRLKGETGIMR------KKFSSLQKEIEERTNDIELLKSEQM 853
Cdd:COG5022  1068 ALKLRRENSLLDDKQLYQLESTENLLKtinVKDLEVTNRNLVKPANVLQfivaqmIKLNLLQEISKFLSQLVNTLEPVFQ 1147

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  854 KLQGiirsLEKDIQGLKREIQERDETIQDKEKRIYdlkkknQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEmE 933
Cdd:COG5022  1148 KLSV----LQLELDGLFWEANLEALPSPPPFAALS------EKRLYQSALYDEKSKLSSSEVNDLKNELIALFSKIFS-G 1216

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  934 AELERFHKQNTQLELNITELLQKLRAT-DQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQR 1012
Cdd:COG5022  1217 WPRGDKLKKLISEGWVPTEYSTSLKGFnNLNKKFDTPASMSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLQYINVG 1296

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1013 ADMVEIAGLNSdLQQEYARQrehLERNlATLKKKVIKEGELHRTDYVRIMQENVSLIKE-----INELRRELKLTRSQIY 1087
Cdd:COG5022  1297 LFNALRTKASS-LRWKSATE---VNYN-SEELDDWCREFEISDVDEELEELIQAVKVLQllkddLNKLDELLDACYSLNP 1371

                         490       500       510
                  ....*....|....*....|....*....|.
gi 568929692 1088 DLESALKVSKKTRSQEVP-ESVISKDVVGST 1117
Cdd:COG5022  1372 AEIQNLKSRYDPADKENNlPKEILKKIEALL 1402
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 613-974 9.94e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 49.83  E-value: 9.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  613 EEVLVTKTDMEEKAQIMLELKTRV-----------EELKMENEYqlrLKDMNYTEKIKELTDKfIQEMESLKTKNQVLKT 681
Cdd:PRK04778  205 EELAALEQIMEEIPELLKELQTELpdqlqelkagyRELVEEGYH---LDHLDIEKEIQDLKEQ-IDENLALLEELDLDEA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  682 EKEKQDIShrERLEELVDKQTRElqdleccnnqkllleYEKYQELQLKSQRMQEEYEKQLRDNDETKSQaLEELTEFYEa 761
Cdd:PRK04778  281 EEKNEEIQ--ERIDQLYDILERE---------------VKARKYVEKNSDTLPDFLEHAKEQNKELKEE-IDRVKQSYT- 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  762 klqektgLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTkyerklrdekesnlrlkgetgimrkkFSSLQKEIEER 841
Cdd:PRK04778  342 -------LNESELESVRQLEKQLESLEKQYDEITERIAEQEIA--------------------------YSELQEELEEI 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  842 TNDIELLKSEQMKLQGIIRSLEKDiqglkrEIQERdETIQDKEKRIYDLK----KKN-----QELEKFKFVLDYKIKELK 912
Cdd:PRK04778  389 LKQLEEIEKEQEKLSEMLQGLRKD------ELEAR-EKLERYRNKLHEIKryleKSNlpglpEDYLEMFFEVSDEIEALA 461

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692  913 KQIEPRENEIKVMKEQIQEMEAELERFHKQNTQL--ELNITE-LLQ---KLRATDQEMRKEQQKERDL 974
Cdd:PRK04778  462 EELEEKPINMEAVNRLLEEATEDVETLEEETEELveNATLTEqLIQyanRYRSDNEEVAEALNEAERL 529
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 614-1150 1.09e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 1.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   614 EVLVTKTDMEEKAQIMLELKTRVEelKMENEYQLRLKdmnytekiKEltDKFIQEMESLKTKNQVLKTEKEKQDISHRER 693
Cdd:pfam01576  163 EFTSNLAEEEEKAKSLSKLKNKHE--AMISDLEERLK--------KE--EKGRQELEKAKRKLEGESTDLQEQIAELQAQ 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   694 LEEL---VDKQTRELQDL------ECCNNQKLLleyEKYQELQLKSQRMQE--EYEKQLRDNDETKSQALEELTEFYEAK 762
Cdd:pfam01576  231 IAELraqLAKKEEELQAAlarleeETAQKNNAL---KKIRELEAQISELQEdlESERAARNKAEKQRRDLGEELEALKTE 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   763 LQEKTGLLEEAQEDVRQQLREFEETKKQIEED---EDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIE 839
Cdd:pfam01576  308 LEDTLDTTAAQQELRSKREQEVTELKKALEEEtrsHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENA 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   840 ERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRiydLKKKNQELEKFKFVL---DYKIKELKKQIE 916
Cdd:pfam01576  388 ELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEK---LSKLQSELESVSSLLneaEGKNIKLSKDVS 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   917 PRENEIKVMKEQIQE--------------MEAE---LERFHKQNTQLELNITELLQKLRATDQEMRKEQQKE----RDLE 975
Cdd:pfam01576  465 SLESQLQDTQELLQEetrqklnlstrlrqLEDErnsLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDagtlEALE 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   976 ALVRRFKTDLHNCVAYIQEPGLLKEKIrglfEKYVQRadmveiaglnsdLQQEY---ARQREHLERNLATLKKKVIKEGE 1052
Cdd:pfam01576  545 EGKKRLQRELEALTQQLEEKAAAYDKL----EKTKNR------------LQQELddlLVDLDHQRQLVSNLEKKQKKFDQ 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1053 L---HRTDYVRIMQENVSLIKEINE-------LRRELKLTRSQIYDLESALKVSKKtrsqEVPESVISKDVVGSTstmrL 1122
Cdd:pfam01576  609 MlaeEKAISARYAEERDRAEAEAREketralsLARALEEALEAKEELERTNKQLRA----EMEDLVSSKDDVGKN----V 680

                          570       580       590
                   ....*....|....*....|....*....|..
gi 568929692  1123 NEQEETGRIIEMQRLEIR----RLRDQIQEQE 1150
Cdd:pfam01576  681 HELERSKRALEQQVEEMKtqleELEDELQATE 712
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 672-985 2.45e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 48.63  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   672 LKTKNQVLKTEKEKQdiSHRERLEELVDKQTRELQDLECCNNQklLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQA 751
Cdd:pfam01576  485 LNLSTRLRQLEDERN--SLQEQLEEEEEAKRNVERQLSTLQAQ--LSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQ 560

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   752 LEELTEFYEaKLQEKTGLLEEAQEDV-------RQQLREFEETKKQIEEDEDREiQDIKTKYERKlRDEKESNLRLKgET 824
Cdd:pfam01576  561 LEEKAAAYD-KLEKTKNRLQQELDDLlvdldhqRQLVSNLEKKQKKFDQMLAEE-KAISARYAEE-RDRAEAEAREK-ET 636

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   825 gimrkKFSSLQKEIEErtndiellkseqmkLQGIIRSLEKDIQGLKREIqerDETIQDKEkriyDLKKKNQELEKFKFVL 904
Cdd:pfam01576  637 -----RALSLARALEE--------------ALEAKEELERTNKQLRAEM---EDLVSSKD----DVGKNVHELERSKRAL 690

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   905 DYKIKELKKQIEPRENEIKVMKE-------QIQEMEAELER-FHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEA 976
Cdd:pfam01576  691 EQQVEEMKTQLEELEDELQATEDaklrlevNMQALKAQFERdLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVA 770


                   ....*....
gi 568929692   977 LVRRFKTDL 985
Cdd:pfam01576  771 AKKKLELDL 779
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-593 2.56e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  425 YKEYQEEAYTVSLHPSGHYIVVGFADK-LRLMNLliDDIRPFKEY-----SVRGCKECSFSNGghLFAAVNGNVIHIFTT 498
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDL--ETGELLRTLkghtgPVRDVAASADGTY--LASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  499 TSLENINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIR----AMKYPLSlqkeynEYQAHAGPVMKMLL 574
Cdd:cd00200    81 ETGECVRTLTGHTSYV-----------SSVAFSPDGRILSSSSRDKTIKvwdvETGKCLT------TLRGHTDWVNSVAF 143

                         170
                  ....*....|....*....
gi 568929692  575 TFDDQFLLTVGEDGCLFTW 593
Cdd:cd00200   144 SPDGTFVASSSQDGTIKLW 162
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 613-899 2.65e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.43  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   613 EEVLVTKTDMEEKAQIMLELKTRVEELKME---NEYQLRLKDMNYTEKIKELTDKFIQEMESLktknqvLKTEKEKQDIS 689
Cdd:TIGR00618  593 TVRLQDLTEKLSEAEDMLACEQHALLRKLQpeqDLQDVRLHLQQCSQELALKLTALHALQLTL------TQERVREHALS 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   690 HRERLEELVDKQTRELQDLEccnNQKLLLEYEKYQELQLKSQ-RMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTG 768
Cdd:TIGR00618  667 IRVLPKELLASRQLALQKMQ---SEKEQLTYWKEMLAQCQTLlRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   769 LLEEAQEDVRQQLREFEETKKQIEEDEDREIQdIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEE----RTND 844
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQ-TGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSdediLNLQ 822

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692   845 IELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEK 899
Cdd:TIGR00618  823 CETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 905-1107 2.85e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  905 DYKIKELKKQIEPRENEIKVMKEQIQEMEAELErfhkqntQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTD 984
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELE-------ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  985 LHNCVAYIQEPGLLKEKIRGL-----FEKYVQRADMVE-IAGLNSDLQQEYARQREHLERNLATLKKKvIKEGELHRTDY 1058
Cdd:COG3883    88 LGERARALYRSGGSVSYLDVLlgsesFSDFLDRLSALSkIADADADLLEELKADKAELEAKKAELEAK-LAELEALKAEL 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568929692 1059 VRIMQENVSLIKE----INELRRELKLTRSQIYDLESALKVSKKTRSQEVPES 1107
Cdd:COG3883   167 EAAKAELEAQQAEqealLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
PRK12704 PRK12704
phosphodiesterase; Provisional
 609-817 3.19e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  609 VGFAEEVLVTKTDMEEKAQIMLEL-KTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEmesLKTKNQVLKtEKEKQD 687
Cdd:PRK12704   16 VGAVIGYFVRKKIAEAKIKEAEEEaKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKE---LRERRNELQ-KLEKRL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  688 ISHrerlEELVDKQTRELQDLEccnnqkllleyekyQELQLKsqrmQEEYEKQLRDNDETKSQaLEELTEFYEAKLQEKT 767
Cdd:PRK12704   92 LQK----EENLDRKLELLEKRE--------------EELEKK----EKELEQKQQELEKKEEE-LEELIEEQLQELERIS 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568929692  768 GLleeAQEDVRQQLreFEETKKQIEEDEDREIQDIKTKYerKLRDEKESN 817
Cdd:PRK12704  149 GL---TAEEAKEIL--LEKVEEEARHEAAVLIKEIEEEA--KEEADKKAK 191
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 667-971 3.37e-05

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 48.21  E-value: 3.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   667 QEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRELQDleccnnqkllleyeKYQELQLKSQRMQEEYEKQLR---- 742
Cdd:pfam09731  106 KEATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATA--------------VAKEAKDDAIQAVKAHTDSLKeasd 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   743 ---DNDETKSQALEELTEFYEAKLQEKTGLLEEAQED-VRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKesnl 818
Cdd:pfam09731  172 taeISREKATDSALQKAEALAEKLKEVINLAKQSEEEaAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQ---- 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   819 rLKGETGIMRKKFsslQKEIEERTNDI-----ELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKK 893
Cdd:pfam09731  248 -YKELVASERIVF---QQELVSIFPDIipvlkEDNLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQKE 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   894 NQE------LEKFKFVLDYKIKELKKQIEPRENEI-KVMKEqiqEMEAELERFHKQNTQlelnitELLQKLRATDQEMRK 966
Cdd:pfam09731  324 ELDklaeelSARLEEVRAADEAQLRLEFEREREEIrESYEE---KLRTELERQAEAHEE------HLKDVLVEQEIELQR 394


                   ....*
gi 568929692   967 EQQKE 971
Cdd:pfam09731  395 EFLQD 399
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 572-967 3.92e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 47.58  E-value: 3.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   572 MLLTFDDQFLLTVGEDGCLFTWKVFDKDGRGIKREREvgfaEEVLVTKTDMEEKAQIMLELKTRVEELKmENEYQLRLKD 651
Cdd:pfam07888   22 MLLVVPRAELLQNRLEECLQERAELLQAQEAANRQRE----KEKERYKRDREQWERQRRELESRVAELK-EELRQSREKH 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   652 MNYTEKIKELTDKfiqeMESLKTKNQVLKTEKEkqdiSHRERLEELVDkqtrelqDLECCNNQKLLLEYE----KYQELQ 727
Cdd:pfam07888   97 EELEEKYKELSAS----SEELSEEKDALLAQRA----AHEARIRELEE-------DIKTLTQRVLERETElermKERAKK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   728 LKSQRMQEEYEkqlRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYE 807
Cdd:pfam07888  162 AGAQRKEEEAE---RKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   808 -RKLRDEKESNLR----LKGETGIMRKKFSSLQKEIEE-RTNDIEL-LKSEQMKL-------------QGIIRSLEKDiq 867
Cdd:pfam07888  239 lRSLQERLNASERkvegLGEELSSMAAQRDRTQAELHQaRLQAAQLtLQLADASLalregrarwaqerETLQQSAEAD-- 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   868 glKREIQERDETIQDKEKRIYDLKKKNQELEKfkfvldykikELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLE 947
Cdd:pfam07888  317 --KDRIEKLSAELQRLEERLQEERMEREKLEV----------ELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQ 384

                          410       420
                   ....*....|....*....|
gi 568929692   948 LNITELLQKLRATDQEMRKE 967
Cdd:pfam07888  385 AEKQELLEYIRQLEQRLETV 404
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 655-980 4.12e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.04  E-value: 4.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   655 TEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHR--ERLEELVDKQTRELQDLECCNnqkllleyekyQELQLKSQR 732
Cdd:TIGR00618  555 RKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNitVRLQDLTEKLSEAEDMLACEQ-----------HALLRKLQP 623

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   733 MQEEYEKQLRDNDETKSQALEELtefyeAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRD 812
Cdd:TIGR00618  624 EQDLQDVRLHLQQCSQELALKLT-----ALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEM 698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   813 EKESNLRLKGEtgimRKKFSSLQKEIEERTNdieLLKSEQMKLQGIIRSLEKDIQGLKRE----IQERDETIQDKEKRIY 888
Cdd:TIGR00618  699 LAQCQTLLREL----ETHIEEYDREFNEIEN---ASSSLGSDLAAREDALNQSLKELMHQartvLKARTEAHFNNNEEVT 771

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   889 DLKKKNQELEKFKFVLDYKIKELkkqiEPRENEIKVMKEQIQE--------MEAELERFHKQNTQLELNITELLQKLRAT 960
Cdd:TIGR00618  772 AALQTGAELSHLAAEIQFFNRLR----EEDTHLLKTLEAEIGQeipsdediLNLQCETLVQEEEQFLSRLEEKSATLGEI 847

                          330       340
                   ....*....|....*....|
gi 568929692   961 DQEMRKEQQKERDLEALVRR 980
Cdd:TIGR00618  848 THQLLKYEECSKQLAQLTQE 867
46 PHA02562
endonuclease subunit; Provisional
 637-873 4.14e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.70  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  637 EELKMENEYQLRLKDMN--YTEKIKELTDKFIQEMESLKT-----KNQVLKTEKEKQDIShrERLEELVDKQTRELQDLE 709
Cdd:PHA02562  195 QQIKTYNKNIEEQRKKNgeNIARKQNKYDELVEEAKTIKAeieelTDELLNLVMDIEDPS--AALNKLNTAAAKIKSKIE 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  710 CCnnQKLLLEYEKYQELQLKSQRMQEEYEKqLRDNDETKSQALEELTefyeaKLQEKTGLLEEAQEDVRQQLREFEETKK 789
Cdd:PHA02562  273 QF--QKVIKMYEKGGVCPTCTQQISEGPDR-ITKIKDKLKELQHSLE-----KLDTAIDELEEIMDEFNEQSKKLLELKN 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  790 QIEEdEDREIQdiktKYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLqGIIRSLEKDiQGL 869
Cdd:PHA02562  345 KIST-NKQSLI----TLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKYHR-GIVTDLLKD-SGI 417


                  ....
gi 568929692  870 KREI 873
Cdd:PHA02562  418 KASI 421
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 619-1090 6.14e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.27  E-value: 6.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   619 KTDMEEKAQImleLKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELV 698
Cdd:TIGR00618  388 KTTLTQKLQS---LCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES 464

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   699 DKQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEE---YEKQLRDNDETKSQALEE--LTEFYEAKLQEkTGLLEEA 773
Cdd:TIGR00618  465 AQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEpcpLCGSCIHPNPARQDIDNPgpLTRRMQRGEQT-YAQLETS 543

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   774 QEDVRQQLREFEETKKQIEEDEDREIQDIkTKYERKLRDEKESNLRLKGETGIMRKKfssLQKEIEERTNDIELLKSEQM 853
Cdd:TIGR00618  544 EEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDL---TEKLSEAEDMLACEQHALLR 619

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   854 KLQGII---------RSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDY--KIKELKKQIEPRENEI 922
Cdd:TIGR00618  620 KLQPEQdlqdvrlhlQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLAlqKMQSEKEQLTYWKEML 699

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   923 KVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATD---QEMRKEQQKERD--LEALVRRFKTDLHNCVAYIQEPGL 997
Cdd:TIGR00618  700 AQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREdalNQSLKELMHQARtvLKARTEAHFNNNEEVTAALQTGAE 779

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   998 LKEKIRGLFEKYVQRADMV-EIAGLNSDLQQE--------------YARQREHLERNLATLKKKV--IKEGELHRTDYVR 1060
Cdd:TIGR00618  780 LSHLAAEIQFFNRLREEDThLLKTLEAEIGQEipsdedilnlqcetLVQEEEQFLSRLEEKSATLgeITHQLLKYEECSK 859

                          490       500       510
                   ....*....|....*....|....*....|
gi 568929692  1061 IMQENVSLIKEINELRRELKLTRSQIYDLE 1090
Cdd:TIGR00618  860 QLAQLTQEQAKIIQLSDKLNGINQIKIQFD 889
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 618-949 6.55e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 47.36  E-value: 6.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   618 TKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYTEKIKEltdKFIQEMESLKTKNQVLKTEKEkqdishRERLEEL 697
Cdd:pfam13166  122 LDKEKEKLEADFLDECWKKIKRKKNSALSEALNGFKYEANFKS---RLLREIEKDNFNAGVLLSDED------RKAALAT 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   698 VDKQTR-ELQDLECcnNQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDetKSQALEELTEFYEAKL-----------QE 765
Cdd:pfam13166  193 VFSDNKpEIAPLTF--NVIDFDALEKAEILIQKVIGKSSAIEELIKNPD--LADWVEQGLELHKAHLdtcpfcgqplpAE 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   766 KTGLLEEA-QEDVRQQLREFEETKKQIEEDEDREIQDIKT--KYERKLRDEKESNLRLKGETGIMRKKFSSLQKEIEER- 841
Cdd:pfam13166  269 RKAALEAHfDDEFTEFQNRLQKLIEKVESAISSLLAQLPAvsDLASLLSAFELDVEDIESEAEVLNSQLDGLRRALEAKr 348

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   842 ------------TNDIELLKSEQMKLQGIIR-------SLEKD------------IQGLKREIQERDETIQDKEKRIYDL 890
Cdd:pfam13166  349 kdpfksieldsvDAKIESINDLVASINELIAkhneitdNFEEEknkakkklrlhlVEEFKSEIDEYKDKYAGLEKAINSL 428

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692   891 KKKNQELEKFKFVLDYKIKELkkqieprENEIKVMKEQIQEMEAELERFHKQNTQLELN 949
Cdd:pfam13166  429 EKEIKNLEAEIKKLREEIKEL-------EAQLRDHKPGADEINKLLKAFGFGELELSFN 480
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 828-976 6.57e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  828 RKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIqdkEKRIYDLKKKNQELEKFKFVL--- 904
Cdd:COG3883    36 QAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL---GERARALYRSGGSVSYLDVLLgse 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  905 ---DY-------------------KIKELKKQIEPRENEIKVMKEQIQEMEAELErfhKQNTQLELNITELLQKLRATDQ 962
Cdd:COG3883   113 sfsDFldrlsalskiadadadlleELKADKAELEAKKAELEAKLAELEALKAELE---AAKAELEAQQAEQEALLAQLSA 189

                         170
                  ....*....|....
gi 568929692  963 EMRKEQQKERDLEA 976
Cdd:COG3883   190 EEAAAEAQLAELEA 203
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 691-1151 6.92e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.05  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   691 RERLEELVDKQTRELQDLeccnNQKLLLEYEKYQELQLKSQRMQEE-YEKQLRDNDETKSQALEELTEFY-EAKLQEKTg 768
Cdd:pfam07111  131 RKNLEEGSQRELEEIQRL----HQEQLSSLTQAHEEALSSLTSKAEgLEKSLNSLETKRAGEAKQLAEAQkEAELLRKQ- 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   769 lLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKlrdekesnlrlkgetgimrKKFSSLQKEIEERTN---DI 845
Cdd:pfam07111  206 -LSKTQEELEAQVTLVESLRKYVGEQVPPEVHSQTWELERQ-------------------ELLDTMQHLQEDRADlqaTV 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   846 ELLkseQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDL-------------KKKNQELEKFKFV--LDYKIKE 910
Cdd:pfam07111  266 ELL---QVRVQSLTHMLALQEEELTRKIQPSDSLEPEFPKKCRSLlnrwrekvfalmvQLKAQDLEHRDSVkqLRGQVAE 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   911 LKKQIEPRENEIKVMKEQIQEMEAEL--ERFHKQNTQLELNitellqklRATDQEMRKEQQ---KERDLEALVRRFKTD- 984
Cdd:pfam07111  343 LQEQVTSQSQEQAILQRALQDKAAEVevERMSAKGLQMELS--------RAQEARRRQQQQtasAEEQLKFVVNAMSSTq 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   985 --LHNCVAYIQE-----PGLLK---------EKIRGLFEKYVQRADM--------VEIAGLNSDLQQEYARQREHLERNL 1040
Cdd:pfam07111  415 iwLETTMTRVEQavariPSLSNrlsyavrkvHTIKGLMARKVALAQLrqescpppPPAPPVDADLSLELEQLREERNRLD 494

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1041 ATLKKKV-IKEGELHRTDYvRIMQENVSLIKEINELRRELKLTRSQIYDLESALKVSKKTRSQEVPESviskdvvGSTST 1119
Cdd:pfam07111  495 AELQLSAhLIQQEVGRARE-QGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEA-------ASLRQ 566

                          490       500       510
                   ....*....|....*....|....*....|...
gi 568929692  1120 MRLNEQEETGRIIEMQRLEIR-RLRDQIQEQEQ 1151
Cdd:pfam07111  567 ELTQQQEIYGQALQEKVAEVEtRLREQLSDTKR 599
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 784-1050 7.64e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 47.13  E-value: 7.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  784 FEETKKQIEE---DEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKF---SSLQKEIEERTNDIELLKSEQMKLQG 857
Cdd:PTZ00440  423 LKENSQKIADyalYSNLEIIEIKKKYDEKINELKKSINQLKTLISIMKSFYdliISEKDSMDSKEKKESSDSNYQEKVDE 502

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  858 IIRSLE--------------------KDIQGLKREIQERDETIQDKEKRIYDLKK--------KNQELEKFKFVLDY--K 907
Cdd:PTZ00440  503 LLQIINsikeknnivnnnfkniedyyITIEGLKNEIEGLIELIKYYLQSIETLIKdeklkrsmKNDIKNKIKYIEENvdH 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  908 IKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRatdqemrkeqqkERDLEALVRRFKTDLHN 987
Cdd:PTZ00440  583 IKDIISLNDEIDNIIQQIEELINEALFNKEKFINEKNDLQEKVKYILNKFY------------KGDLQELLDELSHFLDD 650

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568929692  988 CVAYIQEpGLLKEKIRGLFEKYVQRADmvEIAGLNSDLQQEYARQREHLERNLATLKKKVIKE 1050
Cdd:PTZ00440  651 HKYLYHE-AKSKEDLQTLLNTSKNEYE--KLEFMKSDNIDNIIKNLKKELQNLLSLKENIIKK 710
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
657-886 8.40e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 8.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  657 KIKELTDKFIQEMESLKTKNQVLKTEKEKqdishRERLEELVDKQTRELQDLECCNNQKLLLEY-------EKYQELQLK 729
Cdd:COG4913   222 DTFEAADALVEHFDDLERAHEALEDAREQ-----IELLEPIRELAERYAAARERLAELEYLRAAlrlwfaqRRLELLEAE 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  730 SQRMQEEYEK---QLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQlrefEETKKQIEEDEDReiqdiktkY 806
Cdd:COG4913   297 LEELRAELARleaELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERL----ERELEERERRRAR--------L 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  807 ERKLRDekesnLRLKGETGimRKKFSSLQKEIEERTNDielLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKR 886
Cdd:COG4913   365 EALLAA-----LGLPLPAS--AEEFAALRAEAAALLEA---LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERR 434
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 750-894 8.40e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 8.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  750 QALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDED--------REIQDIK---TKYERKLRDEKESNL 818
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnKEYEALQkeiESLKRRISDLEDEIL 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929692  819 RLKGETGIMRKKFSSLQKEIEERTNDIELLKSEqmkLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKN 894
Cdd:COG1579   114 ELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAEREELAAKIPPELLALYERIRKR 186
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 627-916 9.03e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.71  E-value: 9.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   627 QIMLELKTRVEELkmENEYQLrlkdmnyTEKIKEltdkfiqemeSLKTKNQVLKTEKEKqDISHRERLEE----LVDKQT 702
Cdd:pfam01576  692 QQVEEMKTQLEEL--EDELQA-------TEDAKL----------RLEVNMQALKAQFER-DLQARDEQGEekrrQLVKQV 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   703 RELQ-DLECCNNQK-LLLEYEKYQELQLK--------SQRMQEEYEKQL-----------RDNDETKSQALEELTEFYEA 761
Cdd:pfam01576  752 RELEaELEDERKQRaQAVAAKKKLELDLKeleaqidaANKGREEAVKQLkklqaqmkdlqRELEEARASRDEILAQSKES 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   762 --KLQEKTGLLEEAQEDvrqqLREFEETKKQIEEDEDREIQDIKTKYERK--LRDEKEsnlRLKGetgimrkKFSSLQKE 837
Cdd:pfam01576  832 ekKLKNLEAELLQLQED----LAASERARRQAQQERDELADEIASGASGKsaLQDEKR---RLEA-------RIAQLEEE 897

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   838 IEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELE-----KFKF---VLDYKIK 909
Cdd:pfam01576  898 LEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEgtvksKFKSsiaALEAKIA 977


                   ....*..
gi 568929692   910 ELKKQIE 916
Cdd:pfam01576  978 QLEEQLE 984
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 755-1152 1.00e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 1.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   755 LTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDReIQDIKTKYERKLRDEKESNLRLKGEtgimRKKFSSL 834
Cdd:TIGR04523   27 IANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEK-INNSNNKIKILEQQIKDLNDKLKKN----KDKINKL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   835 QKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQ 914
Cdd:TIGR04523  102 NSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   915 IEPRENEIKVMKEQI-----------------QEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEAL 977
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLlklelllsnlkkkiqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDE 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   978 VRRFKTDLHNcvaYIQEPGLLKEKIRGLfEKYVQRADMvEIAGLNSDLQQEYARQrehLERNLATLKKKVIKegelhrtd 1057
Cdd:TIGR04523  262 QNKIKKQLSE---KQKELEQNNKKIKEL-EKQLNQLKS-EISDLNNQKEQDWNKE---LKSELKNQEKKLEE-------- 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1058 yvrIMQENVSLIKEINELRRELKLTRSQIYDLESalKVSKKTRSQEVPESVISKdvvgststmRLNEQEETGRIIEMQRL 1137
Cdd:TIGR04523  326 ---IQNQISQNNKIISQLNEQISQLKKELTNSES--ENSEKQRELEEKQNEIEK---------LKKENQSYKQEIKNLES 391

                          410
                   ....*....|....*
gi 568929692  1138 EIRRLRDQIQEQEQV 1152
Cdd:TIGR04523  392 QINDLESKIQNQEKL 406
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 745-1151 1.24e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  745 DETKSQALEELTEFYEAKLQEktglleeaqedVRQQLREFEETKKQieeDEDREIQDIKTKYERKLRDEKEsnlrlKGET 824
Cdd:NF033838   53 NESQKEHAKEVESHLEKILSE-----------IQKSLDKRKHTQNV---ALNKKLSDIKTEYLYELNVLKE-----KSEA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  825 GIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDK----EKRIYDLKKKNQELEKF 900
Cdd:NF033838  114 ELTSKTKKELDAAFEQFKKDTLEPGKKVAEATKKVEEAEKKAKDQKEEDRRNYPTNTYKtlelEIAESDVEVKKAELELV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  901 KFVL-----DYKIKELKKQIEPRENEIKVMKE-QIQEMEAELERFHKQNTQLELNITELlqkLRATDQEMRKEQQKERDL 974
Cdd:NF033838  194 KEEAkeprdEEKIKQAKAKVESKKAEATRLEKiKTDREKAEEEAKRRADAKLKEAVEKN---VATSEQDKPKRRAKRGVL 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  975 EALVRRFK--TDLHNCVAYIQE-----PGLLKEKIRGLFEKYVQRAdmveiaglnsdlQQEYARQREHLERNLATLKKKV 1047
Cdd:NF033838  271 GEPATPDKkeNDAKSSDSSVGEetlpsPSLKPEKKVAEAEKKVEEA------------KKKAKDQKEEDRRNYPTNTYKT 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1048 IkEGELHRTDyVRIMQENVSLIKEI-NELRRELKLTRSQIyDLESalKVSKKTRSQEVpesviskdvvgstSTMRLNEQE 1126
Cdd:NF033838  339 L-ELEIAESD-VKVKEAELELVKEEaKEPRNEEKIKQAKA-KVES--KKAEATRLEKI-------------KTDRKKAEE 400

                         410       420
                  ....*....|....*....|....*
gi 568929692 1127 ETGRIIEmqrlEIRRLRDQIQEQEQ 1151
Cdd:NF033838  401 EAKRKAA----EEDKVKEKPAEQPQ 421
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 673-1080 1.27e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.00  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   673 KTKNQVLKTEKEKQDISHRERLEEL--VDKQTRELQDLEccnnqKLLLEYEKYQELQLKSqrmQEEYEKQLRDndetksq 750
Cdd:pfam06160    7 KIYKEIDELEERKNELMNLPVQEELskVKKLNLTGETQE-----KFEEWRKKWDDIVTKS---LPDIEELLFE------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   751 aLEELTE---FYEAK--LQEKTGLLEEAQEDVRQQLREFEETKKQiEEDEDREIQDIKTKYeRKLRDEKESNlrlkgetg 825
Cdd:pfam06160   72 -AEELNDkyrFKKAKkaLDEIEELLDDIEEDIKQILEELDELLES-EEKNREEVEELKDKY-RELRKTLLAN-------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   826 imRKKFSSLQKEIEERTNDIELLKSEQMKL---------QGIIRSLEKDIQGLKR---EIQERDETIQDK-EKRIYDLKK 892
Cdd:pfam06160  141 --RFSYGPAIDELEKQLAEIEEEFSQFEELtesgdyleaREVLEKLEEETDALEElmeDIPPLYEELKTElPDQLEELKE 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   893 KNQELEKFKFVLDYkikelkKQIEPrenEIKVMKEQIQEMEAELERFHKQNTQLELN-ITELLQKLRATdqeMRKEQQKE 971
Cdd:pfam06160  219 GYREMEEEGYALEH------LNVDK---EIQQLEEQLEENLALLENLELDEAEEALEeIEERIDQLYDL---LEKEVDAK 286

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   972 RDLEALVRRFKTDLHNCVAYIQEpglLKEKIRGLFEKYVQRADMVEIaglnsdlQQEYARQREHLERNLATLKKKvIKEG 1051
Cdd:pfam06160  287 KYVEKNLPEIEDYLEHAEEQNKE---LKEELERVQQSYTLNENELER-------VRGLEKQLEELEKRYDEIVER-LEEK 355

                          410       420
                   ....*....|....*....|....*....
gi 568929692  1052 ELHRTDYVRIMQENVSLIKEINELRRELK 1080
Cdd:pfam06160  356 EVAYSELQEELEEILEQLEEIEEEQEEFK 384
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 837-1102 1.36e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 46.37  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   837 EIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIY----DLKKKNQELEKFKFVLDYKIKELK 912
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRtlddQWKEKRDELNGELSAADAAVAKDR 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   913 KQIEPRENEIKV-MKEQIQEMEAELERFHKQNTQLElnitELLQKLRATDQEMRKEQQKERDLEALVrrfKTDLHNCVAY 991
Cdd:pfam12128  322 SELEALEDQHGAfLDADIETAAADQEQLPSWQSELE----NLEERLKALTGKHQDVTAKYNRRRSKI---KEQNNRDIAG 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   992 IQEPgllKEKIRGlfEKYVQRADMveiaglNSDLQQEYARQREHLERNLATLK--KKVIKE--GELH-RTDYVRIMQENV 1066
Cdd:pfam12128  395 IKDK---LAKIRE--ARDRQLAVA------EDDLQALESELREQLEAGKLEFNeeEYRLKSrlGELKlRLNQATATPELL 463

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 568929692  1067 SLIK----EINELRRELKLTRSQIYDLESALKVSKKTRSQ 1102
Cdd:pfam12128  464 LQLEnfdeRIERAREEQEAANAEVERLQSELRQARKRRDQ 503
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 655-1049 1.66e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.98  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   655 TEKIKELTDKFIQEMESLKTKNQvlktEKEKQDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKyQELQLKSQRMQ 734
Cdd:pfam12128  599 EEELRERLDKAEEALQSAREKQA----AAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEK-QSEKDKKNKAL 673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   735 EEY-----------EKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIK 803
Cdd:pfam12128  674 AERkdsanerlnslEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALE 753

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   804 TKYERKLRdekesnlrlkgETGIMRKKFSSLQKEIEERTNDIELlkseqmklqgiIRSLEKDIQGLKREIQERdeTIQDK 883
Cdd:pfam12128  754 TWYKRDLA-----------SLGVDPDVIAKLKREIRTLERKIER-----------IAVRRQEVLRYFDWYQET--WLQRR 809

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   884 EKRIYDLKKKNQELEKFKFVLDYKIKELKKQIepreneikvmkeqiqemeAELERFHKQNTQLELNITELLQKLRAtdqE 963
Cdd:pfam12128  810 PRLATQLSNIERAISELQQQLARLIADTKLRR------------------AKLEMERKASEKQQVRLSENLRGLRC---E 868

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   964 MRKeqQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVEIAGLNSDLQQEYARQREhlerNLATL 1043
Cdd:pfam12128  869 MSK--LATLKEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNVIADHSGSGLAETWESLRE----EDHYQ 942


                   ....*.
gi 568929692  1044 KKKVIK 1049
Cdd:pfam12128  943 NDKGIR 948
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 656-970 1.84e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 45.81  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   656 EKIKELTDKFIQEMESLKTKNQVLKTEKEKQdishrerlEELVDKQTRELQDLECcnNQKLLLEYE-KYQELQLKSQRMQ 734
Cdd:TIGR00606  189 ETLRQVRQTQGQKVQEHQMELKYLKQYKEKA--------CEIRDQITSKEAQLES--SREIVKSYEnELDPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   735 EEYEKQLRDNDETKS-QALEELTEFYEAKLQEKtglLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDE 813
Cdd:TIGR00606  259 HNLSKIMKLDNEIKAlKSRKKQMEKDNSELELK---MEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKER 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   814 KESNLR---LKGETGIMRKKFSSLQKEIEERTNDIELLKSeQMKLQGIIRSLEKDIQ-----GLKREIQERD-----ETI 880
Cdd:TIGR00606  336 RLLNQEkteLLVEQGRLQLQADRHQEHIRARDSLIQSLAT-RLELDGFERGPFSERQiknfhTLVIERQEDEaktaaQLC 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   881 QDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRAT 960
Cdd:TIGR00606  415 ADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNS 494

                          330
                   ....*....|
gi 568929692   961 DQEMRKEQQK 970
Cdd:TIGR00606  495 LTETLKKEVK 504
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 614-1127 1.97e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 45.81  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   614 EVLVTKTDMEEKAQIMLELKTRVEELKMENEYQLRLKDMNYTEKIKELTDKFI------QEMESlKTKNQVLKTEKEKQD 687
Cdd:TIGR00606  344 ELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHtlvierQEDEA-KTAAQLCADLQSKER 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   688 IShRERLEELVDKQTRELQDLEccnNQKLLLEYEKYQELQLKSQRMQ-EEYEKQLRDNDETKSQALEELTEFYEAKLQE- 765
Cdd:TIGR00606  423 LK-QEQADEIRDEKKGLGRTIE---LKKEILEKKQEELKFVIKELQQlEGSSDRILELDQELRKAERELSKAEKNSLTEt 498

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   766 ---KTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQ------DIKTKYERKLRDEKESNLRLKGETGIMRKKfSSLQK 836
Cdd:TIGR00606  499 lkkEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQmemltkDKMDKDEQIRKIKSRHSDELTSLLGYFPNK-KQLED 577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   837 EIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYD----------LKKKNQELEKFKFVL-- 904
Cdd:TIGR00606  578 WLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDvcgsqdeesdLERLKEEIEKSSKQRam 657

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   905 ----------------------------DYKIK-ELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQL--------- 946
Cdd:TIGR00606  658 lagatavysqfitqltdenqsccpvcqrVFQTEaELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqs 737

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   947 -----ELNITELLQKLRATDQEMRKEQ----QKERDLEALVRRFKT--DLHNCVAYIQEPGLLKEKIRGLFEKYVQRADM 1015
Cdd:TIGR00606  738 iidlkEKEIPELRNKLQKVNRDIQRLKndieEQETLLGTIMPEEESakVCLTDVTIMERFQMELKDVERKIAQQAAKLQG 817

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1016 VEI------------------------AGLNSDLQQEYARQREHLERNLATLKKKVIKEGE-LHRTDyvRIMQENVSLIK 1070
Cdd:TIGR00606  818 SDLdrtvqqvnqekqekqheldtvvskIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTnLQRRQ--QFEEQLVELST 895

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568929692  1071 EINELRRELKLTRSQIYDLESAlkvsKKTRSQEVPESVISKDVVGSTSTMRLNEQEE 1127
Cdd:TIGR00606  896 EVQSLIREIKDAKEQDSPLETF----LEKDQQEKEELISSKETSNKKAQDKVNDIKE 948
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 770-984 2.01e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.69  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  770 LEEAQEDVRQQLRE-----FEETKKQIEEDEDREIQDIKTKYER---KLRDEKESNLRLKGETGIMRKK----------- 830
Cdd:PRK05771   14 LKSYKDEVLEALHElgvvhIEDLKEELSNERLRKLRSLLTKLSEaldKLRSYLPKLNPLREEKKKVSVKsleelikdvee 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  831 -FSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEK------DIQ-------------GLKREIQERDETI---------- 880
Cdd:PRK05771   94 eLEKIEKEIKELEEEISELENEIKELEQEIERLEPwgnfdlDLSlllgfkyvsvfvgTVPEDKLEELKLEsdvenveyis 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  881 QDKEKRIY-------DLKKKNQELEKF---KFVLDYK--IKELKKQIEPRENEIkvmKEQIQEMEAELERFHKQNTQLEL 948
Cdd:PRK05771  174 TDKGYVYVvvvvlkeLSDEVEEELKKLgfeRLELEEEgtPSELIREIKEELEEI---EKERESLLEELKELAKKYLEELL 250

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 568929692  949 NITELLqklratdqemrkEQQKERdLEALVRRFKTD 984
Cdd:PRK05771  251 ALYEYL------------EIELER-AEALSKFLKTD 273
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 691-985 2.18e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 45.21  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  691 RERLEELVDKQTRELQDLEccnNQKLLLEYEKYQELQLKSQRmQEEYEKQLRDNDETKSQALEELTE------------- 757
Cdd:PRK04778   24 RKRNYKRIDELEERKQELE---NLPVNDELEKVKKLNLTGQS-EEKFEEWRQKWDEIVTNSLPDIEEqlfeaeelndkfr 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  758 FYEAK--LQEKTGLLEEAQEDVRQQLREFEETKKQiEEDEDREIQDIKTKYeRKLRDEKESNlrlkgetgimRKKFSSLQ 835
Cdd:PRK04778  100 FRKAKheINEIESLLDLIEEDIEQILEELQELLES-EEKNREEVEQLKDLY-RELRKSLLAN----------RFSFGPAL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  836 KEIEERTNDIE--LLKSEQMKLQG-------IIRSLEKDIQGLKR---EIQERDETIQDK-------------------- 883
Cdd:PRK04778  168 DELEKQLENLEeeFSQFVELTESGdyveareILDQLEEELAALEQimeEIPELLKELQTElpdqlqelkagyrelveegy 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  884 -------EKRIYDLKKKNQELEKFKFVLD-----YKIKELKKQI----EPRENEI---KVMKEQIQEMEAELERFHKQNT 944
Cdd:PRK04778  248 hldhldiEKEIQDLKEQIDENLALLEELDldeaeEKNEEIQERIdqlyDILEREVkarKYVEKNSDTLPDFLEHAKEQNK 327

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 568929692  945 QLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDL 985
Cdd:PRK04778  328 ELKEEIDRVKQSYTLNESELESVRQLEKQLESLEKQYDEIT 368
MPS2 pfam17060
Monopolar spindle protein 2; Is a fungal transmembrane protein which is part of the component ...
 810-954 3.58e-04

Monopolar spindle protein 2; Is a fungal transmembrane protein which is part of the component of the spindle pole body (SPB) required for the insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. It seems that Mps2-Spc24 interaction may contribute to the localization of Spc24 and other kinetochore components to the inner plaque of the SPB.


Pssm-ID: 407228 [Multi-domain]  Cd Length: 340  Bit Score: 44.20  E-value: 3.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   810 LRDEKESNLRLKGEtgIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGI------IRSLEKDIQGLKREIQERDETIQDK 883
Cdd:pfam17060   96 IPASFISALELKED--VKSSPRSEADSLGTPIKVDLLRNLKPQESPETPrrinrkYKSLELRVESMKDELEFKDETIMEK 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   884 EKRIYDLKKKNQEL-EKFKFVL------------------------DYKIKELKKQIEPRENEIKVMKEQIQEMEAELER 938
Cdd:pfam17060  174 DRELTELTSTISKLkDKYDFLSrefefykqhhehggnnsiktatkhEFIISELKRKLQEQNRLIRILQEQIQFDPGALHD 253

                          170
                   ....*....|....*.
gi 568929692   939 FHKQNTQLELNITELL 954
Cdd:pfam17060  254 NGPKNLVLNGAIAAVL 269
46 PHA02562
endonuclease subunit; Provisional
 777-973 3.70e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  777 VRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKEsnlrLKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQ 856
Cdd:PHA02562  193 IQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT----IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIK 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  857 GIIRSLEKDI-------------QGLKREiQERDETIQDK----EKRIYDLKKKNQELEKFKFVLD---YKIKELKKQIE 916
Cdd:PHA02562  269 SKIEQFQKVIkmyekggvcptctQQISEG-PDRITKIKDKlkelQHSLEKLDTAIDELEEIMDEFNeqsKKLLELKNKIS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568929692  917 PRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEmRKEQQKERD 973
Cdd:PHA02562  348 TNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKT-KSELVKEKY 403
PRK01156 PRK01156
chromosome segregation protein; Provisional
 729-1002 3.78e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.89  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  729 KSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQL---REFEETKKQIEEDEDR--EIQDIK 803
Cdd:PRK01156  466 KSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSIneyNKIESARADLEDIKIKinELKDKH 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  804 TKYERKlrDEKESNLRLkgetGIMRKKFSSLQKEIEERTN-DIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQD 882
Cdd:PRK01156  546 DKYEEI--KNRYKSLKL----EDLDSKRTSWLNALAVISLiDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDK 619

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  883 KEKRIYD----LKKKNQELEkfkfvldykikELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLeLNITELLQKLR 958
Cdd:PRK01156  620 SIREIENeannLNNKYNEIQ-----------ENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRI-NDIEDNLKKSR 687

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 568929692  959 ATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKI 1002
Cdd:PRK01156  688 KALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKI 731
PRK01156 PRK01156
chromosome segregation protein; Provisional
 763-1152 3.85e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.89  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  763 LQEKTGLLEEAQEDVRQQLREFEETKKQIEEDE------DREIQDIKTKYERKLRDEKESNLRLKGETGI---------- 826
Cdd:PRK01156  178 LRAEISNIDYLEEKLKSSNLELENIKKQIADDEkshsitLKEIERLSIEYNNAMDDYNNLKSALNELSSLedmknryese 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  827 MRKKFSSLQ---------KEIEERTNDIELLKS--------EQMKLQGIIRSLEKDIQGLKREIQERDETIQ-------- 881
Cdd:PRK01156  258 IKTAESDLSmeleknnyyKELEERHMKIINDPVyknrnyinDYFKYKNDIENKKQILSNIDAEINKYHAIIKklsvlqkd 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  882 -----DKEKRIYDLKKKNQELEKFKfvLDY-----KIKELKKQIEPRENEIKVMKEQI-----------QEMEAELERFH 940
Cdd:PRK01156  338 yndyiKKKSRYDDLNNQILELEGYE--MDYnsylkSIESLKKKIEEYSKNIERMSAFIseilkiqeidpDAIKKELNEIN 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  941 KQNTQLELNITELLQKLRATDQemrKEQQKERDLEALVRRFK-----TDL------HNCVAYIQEPGLLKEKIR------ 1003
Cdd:PRK01156  416 VKLQDISSKVSSLNQRIRALRE---NLDELSRNMEMLNGQSVcpvcgTTLgeeksnHIINHYNEKKSRLEEKIReieiev 492

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1004 -GLFEKYVQRADMVE-IAG------LNSDLQQEYAR-QREHLERNLATLKKKVIKEGEL--------------HRTDYVR 1060
Cdd:PRK01156  493 kDIDEKIVDLKKRKEyLESeeinksINEYNKIESARaDLEDIKIKINELKDKHDKYEEIknrykslkledldsKRTSWLN 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1061 IMQEnVSLIkEINELRRELKLTRSQIYDLESALK---VSKKTRSQEVPESVISKDVVGSTSTMRLNEQEETGRIIEMQRL 1137
Cdd:PRK01156  573 ALAV-ISLI-DIETNRSRSNEIKKQLNDLESRLQeieIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRG 650

                         490
                  ....*....|....*
gi 568929692 1138 EIRRLRDQIQEQEQV 1152
Cdd:PRK01156  651 KIDNYKKQIAEIDSI 665
PTZ00332 PTZ00332
paraflagellar rod protein; Provisional
 676-1093 4.25e-04

paraflagellar rod protein; Provisional


Pssm-ID: 240364 [Multi-domain]  Cd Length: 589  Bit Score: 44.57  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  676 NQVLKTEKEKQDIsHRERLE--ELVDKQTRELQDLECCNNQKLLLEYEKYQELQLKSQRMQEEYEKQLRD---------- 743
Cdd:PTZ00332  134 NAIAKMEKVEEEL-RRSQLDatQLAQVPTATLKNIEDIMNVTQIQNALASTDDQIKTQLAQLEKTNEIQNvamhdgemqv 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  744 ---NDETKSQALEELTEFyeakLQEKTGLLEEAqEDVRQQLREFEETKKQIEEdEDREIQDIKtkyeRKLRDEKESNLrl 820
Cdd:PTZ00332  213 aeeQMWTKVQLQERLIEL----VADKFRLIGKC-EEENKSFSKIHEVQKQANQ-ETSQMKDAK----RRLKQRCETDL-- 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  821 kgetgimrkkfsslqKEIEERTNDIELLKSEQMKLQGIIRslEKDiqglKREIQERDETIQDKEKRIYDLKKKNQELEKF 900
Cdd:PTZ00332  281 ---------------KHIHDAIQKADLEDAEAMKRYATNK--EKS----ERFIRENEDRQEEAWNKIQDLERQLQRLGTE 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  901 KFvldykiKELKKQIEP--RENEIKVMKEQIQEMEAE---LERFHKQNTQLELNITELLQKLRA------------TDQE 963
Cdd:PTZ00332  340 RF------EEVKRRIEEndREEKRRVEYQQFLEVAGQhkkLLELTVYNCDLALRCTGLVEELVSegcaavkarhdkTNQD 413

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  964 M---RKEQQKERdLEALVRRFKTdlHNCVAYIQEPgLLKEKIRGLFEKYVQRADMVEI----AGLNSDLQQEYARQREHL 1036
Cdd:PTZ00332  414 LaalRLQVHKEH-LEYFRMLYLT--LGSLIYKKEK-RLEEIDRNIRTTHIQLEFCVETfdpnAKKHADMKKELYKLRQGV 489

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568929692 1037 ERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLESAL 1093
Cdd:PTZ00332  490 EEELAMLKEKQAQALEMFKESEEALDAAGIEFVHPVDENNEEVLTRRSKMVEYRSHL 546
PRK01156 PRK01156
chromosome segregation protein; Provisional
 679-926 5.26e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.51  E-value: 5.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  679 LKTEKEKQDISH----RERLEELVDKQTRELQDL-ECCNNQKLLLEYEKYQELQ--LKSQRMQEEYEKQLRDNDETKSQA 751
Cdd:PRK01156  462 LGEEKSNHIINHynekKSRLEEKIREIEIEVKDIdEKIVDLKKRKEYLESEEINksINEYNKIESARADLEDIKIKINEL 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  752 LEELTEFYEAKLQEKTGLLEEAQE---------------DVRQQLREFEETKKQIEEDEDR------EIQDIKTKYERKL 810
Cdd:PRK01156  542 KDKHDKYEEIKNRYKSLKLEDLDSkrtswlnalavisliDIETNRSRSNEIKKQLNDLESRlqeieiGFPDDKSYIDKSI 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  811 R--DEKESNLRLKgetgimRKKFSSLQKEIEERTNDIELLKSEQMKLQGIirslEKDIQGLKREIQERDETIQDKEKRIY 888
Cdd:PRK01156  622 ReiENEANNLNNK------YNEIQENKILIEKLRGKIDNYKKQIAEIDSI----IPDLKEITSRINDIEDNLKKSRKALD 691

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 568929692  889 DLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMK 926
Cdd:PRK01156  692 DAKANRARLESTIEILRTRINELSDRINDINETLESMK 729
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 753-891 5.34e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 5.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   753 EELTEFYeAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYE---RKLRDEKESNLRLKGEtgimrk 829
Cdd:pfam08614    3 LELIDAY-NRLLDRTALLEAENAKLQSEPESVLPSTSSSKLSKASPQSASIQSLEqllAQLREELAELYRSRGE------ 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   830 kfssLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLK 891
Cdd:pfam08614   76 ----LAQRLVDLNEELQELEKKLREDERRLAALEAERAQLEEKLKDREEELREKRKLNQDLQ 133
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 889-1151 5.78e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.86  E-value: 5.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   889 DLKKKNQ-ELEKfkfvLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNI---TELLQKLRATDQEM 964
Cdd:pfam05667  328 ELQQQREeELEE----LQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYkvkKKTLDLLPDAEENI 403

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   965 RKEQQK----ERDLEALVRRFKTdlHNcVAYIQEPGLLKEKIRGLFEKYVQRADmvEIAGLNSDLQQ--EYARQREHLER 1038
Cdd:pfam05667  404 AKLQALvdasAQRLVELAGQWEK--HR-VPLIEEYRALKEAKSNKEDESQRKLE--EIKELREKIKEvaEEAKQKEELYK 478

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1039 NLATLKKKVIKEGelHRTDYVRIMQENVSLIK----EINELRRELKLTRSQIYDLESALKvskktRSQEVPESVISKDVV 1114
Cdd:pfam05667  479 QLVAEYERLPKDV--SRSAYTRRILEIVKNIKkqkeEITKILSDTKSLQKEINSLTGKLD-----RTFTVTDELVFKDAK 551

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568929692  1115 GSTS---------TMRLN-EQ-----EETGRIIEmqrlEIRRLRDQIQEQEQ 1151
Cdd:pfam05667  552 KDESvrkaykylaALHENcEQliqtvEETGTIMR----EIRDLEEQIETESG 599
WD40 pfam00400
WD domain, G-beta repeat;
387-416 5.95e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.95e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568929692   387 HSASITGLDTCIRKPLIATCSLDRSVRIWN 416
Cdd:pfam00400   10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 837-1046 6.11e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  837 EIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKriydlkkknqelekfkfvldyKIKELKKQIE 916
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQA---------------------EIDKLQAEIA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  917 PRENEIKVMKEQIQEMEAELERFHKQNTQLEL-----NITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAY 991
Cdd:COG3883    76 EAEAEIEERREELGERARALYRSGGSVSYLDVllgseSFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAK 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692  992 IQEPGLLKEKIRGLfEKYVQRAdMVEIAGLNSDLQQEYARQREHLERNLATLKKK 1046
Cdd:COG3883   156 LAELEALKAELEAA-KAELEAQ-QAEQEALLAQLSAEEAAAEAQLAELEAELAAA 208
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 614-977 6.74e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.96  E-value: 6.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   614 EVLVTKTDMEEKAQIMLELKTRVEELKMENE----YQLRLKDMNytEKIKELTDKF-IQEMESLKTKN------QVLKTE 682
Cdd:pfam05557  126 ELQSTNSELEELQERLDLLKAKASEAEQLRQnlekQQSSLAEAE--QRIKELEFEIqSQEQDSEIVKNskselaRIPELE 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   683 KEKQDI-SHRERLEELvdKQTRELQDLECCNNQKLLLEYEKYQE----LQLKSQRMQEEYE--KQLRDNDETKSQALEEL 755
Cdd:pfam05557  204 KELERLrEHNKHLNEN--IENKLLLKEEVEDLKRKLEREEKYREeaatLELEKEKLEQELQswVKLAQDTGLNLRSPEDL 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   756 TEFYEAKLQEKTGLLEEaQEDVRQQLREFEETKKQIEEDED---REIQDIKTKYERK---LRDEKESNLRLKGETGIMRK 829
Cdd:pfam05557  282 SRRIEQLQQREIVLKEE-NSSLTSSARQLEKARRELEQELAqylKKIEDLNKKLKRHkalVRRLQRRVLLLTKERDGYRA 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   830 KFSSLQKEIEERTNDIELLKS----EQM--KLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFV 903
Cdd:pfam05557  361 ILESYDKELTMSNYSPQLLERieeaEDMtqKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLADPSYSK 440

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568929692   904 LDYKikELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTqLELNITELLQkLRATDQEMRKEQQKErDLEAL 977
Cdd:pfam05557  441 EEVD--SLRRKLETLELERQRLREQKNELEMELERRCLQGD-YDPKKTKVLH-LSMNPAAEAYQQRKN-QLEKL 509
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
 749-1035 6.95e-04

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 43.53  E-value: 6.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   749 SQALEEL------TEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERkLRDEKESNLRLKG 822
Cdd:pfam04108   20 RSLLEELvvllakIAFLRRGLSVQLANLEKVREGLEKVLNELKKDFKQLLKDLDAALERLEETLDK-LRNTPVEPALPPG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   823 ETG-------IMRKKFSSLQKEIEErtnDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDEtIQDKEKRIYDLKKKNQ 895
Cdd:pfam04108   99 EEKqktlldfIDEDSVEILRDALKE---LIDELQAAQESLDSDLKRFDDDLRDLQKELESLSS-PSESISLIPTLLKELE 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   896 ELEK------FKFVLDY-KIKELKKQIEPRENE---------------IKVMKEQIQEMEAELERFHKQNTQLELNITEL 953
Cdd:pfam04108  175 SLEEemasllESLTNHYdQCVTAVKLTEGGRAEmlevlendarelddvVPELQDRLDEMENNYERLQKLLEQKNSLIDEL 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   954 ---LQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYV-----QRADMVEIAGLNSDL 1025
Cdd:pfam04108  255 lsaLQLIAEIQSRLPEYLAALKEFEERWEEEKETIEDYLSELEDLREFYEGFPSAYGSLLleverRREWAEKMKKILRKL 334

                          330
                   ....*....|
gi 568929692  1026 QQEYARQREH 1035
Cdd:pfam04108  335 AEELDRLQEE 344
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 676-980 8.09e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.98  E-value: 8.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   676 NQVLKTEKEKQDISHRERLEELVDKQTRELQDLECCNNQKLLLEYEKYQ----ELQLKSQRMQEEYEKQLRDNDETKSQA 751
Cdd:pfam13868   31 KKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEeqieEREQKRQEEYEEKLQEREQMDEIVERI 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   752 LEELTEFYEAKLQEKTGLLEEAQEDVRQQlREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKF 831
Cdd:pfam13868  111 QEEDQAEAEEKLEKQRQLREEIDEFNEEQ-AEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   832 SSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKnqelekfkfvldyKIKEL 911
Cdd:pfam13868  190 RAQQEKAQDEKAERDELRAKLYQEEQERKERQKEREEAEKKARQRQELQQAREEQIELKERR-------------LAEEA 256

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568929692   912 KKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQ----LELNITELLQKLRATDQEMRKEQQKERDLEALVRR 980
Cdd:pfam13868  257 EREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEhrreLEKQIEEREEQRAAEREEELEEGERLREEEAERRE 329
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-416 9.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 9.59e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568929692    384 YPLHSASITGLDTCIRKPLIATCSLDRSVRIWN 416
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 636-937 1.07e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.50  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   636 VEELKMENEYQLRLKDMN-YTEKIKELTDKFIQEMESLKTknqVLKTEKE-KQDISHRERLEELVDKQTRELQDLECcNN 713
Cdd:TIGR01612 1401 LEECKSKIESTLDDKDIDeCIKKIKELKNHILSEESNIDT---YFKNADEnNENVLLLFKNIEMADNKSQHILKIKK-DN 1476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   714 QKLLLEYE--KYQELQLKSQRMQEEYEK---QLRDNDETKSQALEELTE----FYEAKLQEKtglLEEAQEDVRQQLREF 784
Cdd:TIGR01612 1477 ATNDHDFNinELKEHIDKSKGCKDEADKnakAIEKNKELFEQYKKDVTEllnkYSALAIKNK---FAKTKKDSEIIIKEI 1553

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   785 EETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQKE--------IEERTNDIeLLKSEQMKLQ 856
Cdd:TIGR01612 1554 KDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFEnkflkisdIKKKINDC-LKETESIEKK 1632

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   857 giIRSLEKDIQGLK--------REIQERDETIQDKEKRIYDLKKK----NQELEKFKFVLDYKIKELKKQIEPRENEI-K 923
Cdd:TIGR01612 1633 --ISSFSIDSQDTElkengdnlNSLQEFLESLKDQKKNIEDKKKEldelDSEIEKIEIDVDQHKKNYEIGIIEKIKEIaI 1710

                          330
                   ....*....|....
gi 568929692   924 VMKEQIQEMEAELE 937
Cdd:TIGR01612 1711 ANKEEIESIKELIE 1724
PRK12704 PRK12704
phosphodiesterase; Provisional
 848-971 1.35e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.84  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  848 LKSEQMKLQGIIRSLEKDIQGLKREI--QERDETIQDKEKRIYDLKKKNQELEKfkfvldykikeLKKQIEPRENEIKVM 925
Cdd:PRK12704   33 IKEAEEEAKRILEEAKKEAEAIKKEAllEAKEEIHKLRNEFEKELRERRNELQK-----------LEKRLLQKEENLDRK 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568929692  926 KEQIQEMEAELERFHKQNTQLELNITELLQKLratdQEMRKEQQKE 971
Cdd:PRK12704  102 LELLEKREEELEKKEKELEQKQQELEKKEEEL----EELIEEQLQE 143
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
622-980 1.35e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  622 MEEKAQIMLELKTRVEELKMENEYQLRLKdmnytEKIKELTDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQ 701
Cdd:COG4717   134 LEALEAELAELPERLEELEERLEELRELE-----EELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  702 TRELQDLECCNNQkllLEYEKYQELQLKSQRMQEEYEKQLRDND------------ETKSQALEELTEFYEAKLQEKTGL 769
Cdd:COG4717   209 AELEEELEEAQEE---LEELEEELEQLENELEAAALEERLKEARlllliaaallalLGLGGSLLSLILTIAGVLFLVLGL 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  770 L------EEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKkfssLQKEIEERTN 843
Cdd:COG4717   286 LallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQE----LLREAEELEE 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  844 DIELLKSEQMKLQGIIRSLEKDIQGLkREIQERDETIQDKEKRIYDLKKK-NQELEKFKFVLDY--------KIKELKKQ 914
Cdd:COG4717   362 ELQLEELEQEIAALLAEAGVEDEEEL-RAALEQAEEYQELKEELEELEEQlEELLGELEELLEAldeeeleeELEELEEE 440

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568929692  915 IEPRENEIKVMKEQIQEMEAELERFHKQNTqlelnITELLQKlratdQEMRKEQQKERDLEALVRR 980
Cdd:COG4717   441 LEELEEELEELREELAELEAELEQLEEDGE-----LAELLQE-----LEELKAELRELAEEWAALK 496
WD40 COG2319
WD40 repeat [General function prediction only];
26-189 1.44e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   26 DEQIIIFPSGNHCVK-YNID-QKWQKFIAGSdkSQGMLALAISPNRRYLAiseTVQEKPAVTIYELSSipcrkRKVLNNF 103
Cdd:COG2319   215 DGKLLASGSADGTVRlWDLAtGKLLRTLTGH--SGSVRSVAFSPDGRLLA---SGSADGTVRLWDLAT-----GELLRTL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  104 DFQVQKFTSMAFSPDSKYLLTQTSppDSNLVYWLWEKQKVMAIIKADSqnNPIYQVSISSqDNSQVcITGS--GVFKLLR 181
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSP-DGKTL-ASGSddGTVRLWD 358


                  ....*...
gi 568929692  182 FAEGTLKQ 189
Cdd:COG2319   359 LATGELLR 366
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 629-1129 1.47e-03

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 43.01  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   629 MLELKTR----VEELKMENEyqlrlKDMNYTEKIkeltDKFIQEMESLKTKNQVLKTEKEKQDISHRERLEELvdkqtre 704
Cdd:pfam15818    2 LLDFKTSlleaLEELRMRRE-----AETQYEEQI----GKIIVETQELKWQKETLQNQKETLAKQHKEAMAVF------- 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   705 lqdleccnnqkllleyekYQELQLKSQRMQEEYEK-QLRDndETKSQALEELTEFYEA------KLQEKtglLEEAQEDV 777
Cdd:pfam15818   66 ------------------KKQLQMKMCALEEEKGKyQLAT--EIKEKEIEGLKETLKAlqvskySLQKK---VSEMEQKL 122

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   778 RQQLREFEETKKQIEEDEdreiqdiktKYERKLrdekesnlrlKGETGIMRKKFSSLQKEIEERtndIELLKseqmKLQG 857
Cdd:pfam15818  123 QLHLLAKEDHHKQLNEIE---------KYYATI----------TGQFGLVKENHGKLEQNVQEA---IQLNK----RLSA 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   858 IIRSLEKDIQGLKREiqerdetiqdkekriydLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQeMEAEL- 936
Cdd:pfam15818  177 LNKKQESEICSLKKE-----------------LKKVTSDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLN-MELELn 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   937 ERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEAlvrrfktdlhncvayiqEPGLLKEKIRGLfekyvQRadmv 1016
Cdd:pfam15818  239 KKINEEITHIQEEKQDIIISFQHMQQLLQQQTQANTEMEA-----------------ELKALKENNQTL-----ER---- 292

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1017 eiaglNSDLQQEYARQREHLERNLATLKKKVIKEGELHRTDYVRIMQENVSLIKEINELRRELKLTRSQIYDLEsalKVS 1096
Cdd:pfam15818  293 -----DNELQREKVKENEEKFLNLQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQEHYNKLCNQK---KFE 364

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 568929692  1097 KKTRSQEVPE-----SVISKDVVGSTSTMRLNEQEETG 1129
Cdd:pfam15818  365 EDKKFQNVPEvnnenSEMSTEKSENLIIQKYNSEQEIR 402
EzrA COG4477
Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome ...
 826-1090 1.47e-03

Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443574 [Multi-domain]  Cd Length: 567  Bit Score: 42.52  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  826 IMRKKFSSLQKEIEERTNDI-------ELLKSEQMKLQGiirslekDIQGLKREIQERDETIQDK-----EKRIYDLKkk 893
Cdd:COG4477    21 IMRKKHYKEIDRLEERKLEImnrpvldELSKVKKLNLSG-------QTEEKFEEWRQKWDEIVTKqlpeiEELLFDAE-- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  894 nQELEKFKFvldykiKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRatdqEMRKEQQKERD 973
Cdd:COG4477    92 -EAADKFRF------KKAKKALDEIEQLLDEIEEEIEEILEELEELLESEEKNREEIEELKEKYR----ELRKTLLAHRH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  974 --------LEALVRRFKTDLHNCVAYIQEpG----------LLKEKIRGLFEKyvqradMVEIAGLNSDLQQEYARQREH 1035
Cdd:COG4477   161 sfgpaaeeLEKQLEELEPEFEEFEELTES-GdyleareileQLEEELNALEEL------MEEIPPLLKELQTELPDQLEE 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692 1036 LERNLATLKKKvikegelhrtDYVRimqENVSLIKEINELRRELKLTRSQIYDLE 1090
Cdd:COG4477   234 LKSGYREMKEQ----------GYVL---EHLNIEKEIEQLEEQLKEALELLEELD 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 503-606 1.59e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  503 NINILKGHTGKIlreipafdviyTSITISHSGRMIFVGTSVGTIRamKYPLSLQKEYNEYQAHAGPVMKMLLTFDDQFLL 582
Cdd:cd00200     1 LRRTLKGHTGGV-----------TCVAFSPDGKLLATGSGDGTIK--VWDLETGELLRTLKGHTGPVRDVAASADGTYLA 67

                          90       100
                  ....*....|....*....|....
gi 568929692  583 TVGEDGCLftwKVFDKDGRGIKRE 606
Cdd:cd00200    68 SGSSDKTI---RLWDLETGECVRT 88
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
914-1151 1.65e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  914 QIEPRENEIKVmkEQIQEMEAELERFhkqNTQLEL-----NITELLQKLRATDQEMRKEQQKERDLEALVRRFK------ 982
Cdd:COG3206    60 LVEPQSSDVLL--SGLSSLSASDSPL---ETQIEIlksrpVLERVVDKLNLDEDPLGEEASREAAIERLRKNLTvepvkg 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  983 TDLHNcVAYI-QEPGLLKEKIRGLFEKYVQRadmveiaglNSDLQQEYARQ-REHLERNLATLKKKVIK-EGELH----R 1055
Cdd:COG3206   135 SNVIE-ISYTsPDPELAAAVANALAEAYLEQ---------NLELRREEARKaLEFLEEQLPELRKELEEaEAALEefrqK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1056 TDYVRIMQENVSLIKEINELRRELKLTRSQIYDLESALK-VSKKTRSQEVPESVISKDVVGSTSTMRLNEQEetGRIIEM 1134
Cdd:COG3206   205 NGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAaLRAQLGSGPDALPELLQSPVIQQLRAQLAELE--AELAEL 282

                         250       260
                  ....*....|....*....|...
gi 568929692 1135 QRL------EIRRLRDQIQEQEQ 1151
Cdd:COG3206   283 SARytpnhpDVIALRAQIAALRA 305
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
690-984 1.75e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  690 HRERLEELVDKQTRELQDLEccNNQKLLLEYEKYQELQLKSQRMQEEY---EKQLRDNDETKS--QALEELTEFYEAKLQ 764
Cdd:COG4913   625 ELAEAEERLEALEAELDALQ--ERREALQRLAEYSWDEIDVASAEREIaelEAELERLDASSDdlAALEEQLEELEAELE 702

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  765 EKTGLLEEAQEDVRQQLREFEETKKQIEEDEDR--EIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSS----LQKEI 838
Cdd:COG4913   703 ELEEELDELKGEIGRLEKELEQAEEELDELQDRleAAEDLARLELRALLEERFAAALGDAVERELRENLEEridaLRARL 782

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  839 EERTNDIELLKSE-----QMKLQGIIRSLEK--DIQGLKREIQERDetIQDKEKRIYDLKKKNQElekfkfvldYKIKEL 911
Cdd:COG4913   783 NRAEEELERAMRAfnrewPAETADLDADLESlpEYLALLDRLEEDG--LPEYEERFKELLNENSI---------EFVADL 851

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  912 KKQIeprENEIKVMKEQIQEMEAELE----------RFHKQNTQLElNITELLQKLR-----ATDQEMRKEQQKERDLEA 976
Cdd:COG4913   852 LSKL---RRAIREIKERIDPLNDSLKripfgpgrylRLEARPRPDP-EVREFRQELRavtsgASLFDEELSEARFAALKR 927


                  ....*...
gi 568929692  977 LVRRFKTD 984
Cdd:COG4913   928 LIERLRSE 935
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 771-976 1.82e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  771 EEAQEDVRQQLREFEETKKQIEEdedrEIQDIKTKYERklrdekesnlrlkgetgiMRKKFSSLQKEIEERTNDIELLKS 850
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQA----ELDALQAELEE------------------LNEEYNELQAELEALQAEIDKLQA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  851 EQMKLQGIIRSLEKDIQGLKREIQERD-------------------------ETIQDKEKRIYD-LKKKNQELEKFKFVL 904
Cdd:COG3883    73 EIAEAEAEIEERREELGERARALYRSGgsvsyldvllgsesfsdfldrlsalSKIADADADLLEeLKADKAELEAKKAEL 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692  905 DYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEA 976
Cdd:COG3883   153 EAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAA 224
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 625-1104 1.89e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   625 KAQIMLELKTRVEELKMENEYQLRLKDMNYTEKIKELtdkfiQEMES-LKTKNQVLKTEKEKQDISHRERLEEL------ 697
Cdd:pfam12128  381 RSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDL-----QALESeLREQLEAGKLEFNEEEYRLKSRLGELklrlnq 455

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   698 VDKQTRELQDLEccNNQKLLleyEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFyEAKLQEKTGLLEEAQEDV 777
Cdd:pfam12128  456 ATATPELLLQLE--NFDERI---ERAREEQEAANAEVERLQSELRQARKRRDQASEALRQA-SRRLEERQSALDELELQL 529

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   778 RQQ---LREFEETKKQIEEDE--------------------DREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSL 834
Cdd:pfam12128  530 FPQagtLLHFLRKEAPDWEQSigkvispellhrtdldpevwDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKA 609

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   835 QKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQdkekRIYDLK-----KKNQELEKFKFVLDYKIK 909
Cdd:pfam12128  610 EEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR----RLFDEKqsekdKKNKALAERKDSANERLN 685

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   910 ELKKQIEPRENEIKVMKEQIQEMEAELeRFHKQNTQLELnITELLQKLRATDQEMRK------------EQQKERDLEAL 977
Cdd:pfam12128  686 SLEAQLKQLDKKHQAWLEEQKEQKREA-RTEKQAYWQVV-EGALDAQLALLKAAIAArrsgakaelkalETWYKRDLASL 763

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   978 ------VRRFKTDLHNCVAYIQEPGLLKEKIRGLF----EKYVQRAD-----MVEIAGLNSDLQQEYARQ-------REH 1035
Cdd:pfam12128  764 gvdpdvIAKLKREIRTLERKIERIAVRRQEVLRYFdwyqETWLQRRPrlatqLSNIERAISELQQQLARLiadtklrRAK 843

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692  1036 LERNLATLKKKVIKEGELHRTdyVRIMQENVSLIKE---INELRRELKLTRSQIYDLESALKVSKKTRSQEV 1104
Cdd:pfam12128  844 LEMERKASEKQQVRLSENLRG--LRCEMSKLATLKEdanSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYV 913
PLN02939 PLN02939
transferase, transferring glycosyl groups
 792-1105 2.01e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.58  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  792 EEDEDREIQDIKTKYERKLRDEKESNLRlKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMK-LQGIIRSLEKDIQGLK 870
Cdd:PLN02939   70 DENGQLENTSLRTVMELPQKSTSSDDDH-NRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLEdLVGMIQNAEKNILLLN 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  871 reiQERDETIQDKEKRIYDLKKKNQELEkfkfVLDYKIKELKKQIE-----------PRENEIKVMKEQIQEMEA----- 934
Cdd:PLN02939  149 ---QARLQALEDLEKILTEKEALQGKIN----ILEMRLSETDARIKlaaqekihveiLEEQLEKLRNELLIRGATeglcv 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  935 -----ELERFHKQNTQLELNITELLQKL---RATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLK-----EK 1001
Cdd:PLN02939  222 hslskELDVLKEENMLLKDDIQFLKAELievAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSKLSPLQydcwwEK 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1002 IRGLFEKYVQRADMVEIAGLNSDLQQEYARQREHLErnlATLKKKVIKEGELHRTDyvrIMQENVSLIKEINELRRELKL 1081
Cdd:PLN02939  302 VENLQDLLDRATNQVEKAALVLDQNQDLRDKVDKLE---ASLKEANVSKFSSYKVE---LLQQKLKLLEERLQASDHEIH 375

                         330       340       350
                  ....*....|....*....|....*....|..
gi 568929692 1082 TRSQIY--------DLESALKVSKKTRSQEVP 1105
Cdd:PLN02939  376 SYIQLYqesikefqDTLSKLKEESKKRSLEHP 407
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
755-1040 2.13e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  755 LTEFYEAKLQEKTGLLEEAqEDVRQQLREFEETKKQIEEDEDR-----EIQDIKTKYERKLRDekesnlrlKGETGIMRK 829
Cdd:COG4913   209 LDDFVREYMLEEPDTFEAA-DALVEHFDDLERAHEALEDAREQiellePIRELAERYAAARER--------LAELEYLRA 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  830 KFSSLQKEIEertndIELLKSEqmklqgiIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKnqelekfkfvldykIK 909
Cdd:COG4913   280 ALRLWFAQRR-----LELLEAE-------LEELRAELARLEAELERLEARLDALREELDELEAQ--------------IR 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  910 ELK-KQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDlhnc 988
Cdd:COG4913   334 GNGgDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAE---- 409

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568929692  989 vayiqepglLKEKIRGLFEKYVQRADmvEIAGL---NSDLQQEYARQREHLERNL 1040
Cdd:COG4913   410 ---------AEAALRDLRRELRELEA--EIASLerrKSNIPARLLALRDALAEAL 453
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 342-461 2.17e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  342 CLCFSPSEETLIASTNKNQLYSI---TMSLTEISKGEAahfeyllyplhSASITGLDTCIRKPLIATCSLDRSVRIWNYE 418
Cdd:cd22857   228 AVAEDPDGHTVYVGDTSGDLASIdlrTGKLLGCFKGKC-----------GGSIRSIARHPELPLIASCGLDRYLRIWDTE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568929692  419 SNTLeLYKEYqeeaytvslhpsghyivvgfaDKLRLMNLLIDD 461
Cdd:cd22857   297 TRQL-LSKVY---------------------LKQRLTAVVFDS 317
Filament pfam00038
Intermediate filament protein;
656-985 2.18e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.44  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   656 EKIKELTDKF---IQEMESLKTKNQVLKTE-KEKQDISHRE--RLEELVDKQTRELQDleccnnqkllleyekyQELQLK 729
Cdd:pfam00038    4 EQLQELNDRLasyIDKVRFLEQQNKLLETKiSELRQKKGAEpsRLYSLYEKEIEDLRR----------------QLDTLT 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   730 SQRMQEEYEkqlRDNdetksqaLEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEET-------KKQIEEDEDrEIQDI 802
Cdd:pfam00038   68 VERARLQLE---LDN-------LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEAtlarvdlEAKIESLKE-ELAFL 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   803 KTKYERKLRDekesnlrlkgetgimrkkfssLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGL-KREIQERDETIQ 881
Cdd:pfam00038  137 KKNHEEEVRE---------------------LQAQVSDTQVNVEMDAARKLDLTSALAEIRAQYEEIaAKNREEAEEWYQ 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   882 DKEKRIYDLKKKNQElekfkfvldykikelkkQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLratD 961
Cdd:pfam00038  196 SKLEELQQAAARNGD-----------------ALRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETEERY---E 255

                          330       340
                   ....*....|....*....|....
gi 568929692   962 QEMRKEQQKERDLEALVRRFKTDL 985
Cdd:pfam00038  256 LQLADYQELISELEAELQETRQEM 279
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 635-1003 2.18e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   635 RVEELKMENEYQLRLKDmNYTEKIKELTDKfIQEMESLKTKNQVLKTEKEKQDISHRERLEELVDKQTRElQDLECCNNQ 714
Cdd:TIGR01612 1230 KIDEEKKKSEHMIKAME-AYIEDLDEIKEK-SPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHD-ENISDIREK 1306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   715 KLLLEYEKYQELQLKSqrMQEEYEKQLRDNDETKS---QALEELTEFYEA-----------KLQEKTGLLEEAQEDVRQQ 780
Cdd:TIGR01612 1307 SLKIIEDFSEESDIND--IKKELQKNLLDAQKHNSdinLYLNEIANIYNIlklnkikkiidEVKEYTKEIEENNKNIKDE 1384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   781 LREFEETKKQIEEDEDreIQDIKTKYERKLRDekesnlrlkgetgimrkkfsslqKEIEERTNDIELLKSEqmklqgiIR 860
Cdd:TIGR01612 1385 LDKSEKLIKKIKDDIN--LEECKSKIESTLDD-----------------------KDIDECIKKIKELKNH-------IL 1432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   861 SLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFK-----FVLDYKIKELKKQIEprenEIKVMKEQIQEMEAE 935
Cdd:TIGR01612 1433 SEESNIDTYFKNADENNENVLLLFKNIEMADNKSQHILKIKkdnatNDHDFNINELKEHID----KSKGCKDEADKNAKA 1508

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692   936 LERFHKQNTQLELNITELLQKLRATDQEMRKEQQKeRDLEALVRRFKtDLHNcvAYIQEPGLLKEKIR 1003
Cdd:TIGR01612 1509 IEKNKELFEQYKKDVTELLNKYSALAIKNKFAKTK-KDSEIIIKEIK-DAHK--KFILEAEKSEQKIK 1572
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 880-1003 2.29e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 41.67  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   880 IQDKEKRIYDLKK------------KNQELEKFKFVLDykikELKKQIEPRENEIKVMKEQIQEMEA----ELERFHKQN 943
Cdd:pfam09787   20 LQSKEKLIASLKEgsgvegldsstaLTLELEELRQERD----LLREEIQKLRGQIQQLRTELQELEAqqqeEAESSREQL 95

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   944 TQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCvayIQEPGLLKEKIR 1003
Cdd:pfam09787   96 QELEEQLATERSARREAEAELERLQEELRYLEEELRRSKATLQSR---IKDREAEIEKLR 152
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 667-897 2.31e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 42.15  E-value: 2.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   667 QEMESLKTKNQVLKTEKEKqdishrerleelvDKQTreLQDLEccnnQKLLLEyekyqelqlksQRMQEEYEKQLrdNDE 746
Cdd:pfam09726  444 QENDLLQTKLHNAVSAKQK-------------DKQT--VQQLE----KRLKAE-----------QEARASAEKQL--AEE 491

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   747 TKSQALEELTEFYEAKLQEKTglLEEAQEDVRQQLREFE-ETKK-----QIEEDEDREIqDIKTKyerKLRDEKESnlrl 820
Cdd:pfam09726  492 KKRKKEEEATAARAVALAAAS--RGECTESLKQRKRELEsEIKKlthdiKLKEEQIREL-EIKVQ---ELRKYKES---- 561

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568929692   821 KGETGIMRKKFSSLQKEIEERTNDielLKSE-QMKLqgiirSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQEL 897
Cdd:pfam09726  562 EKDTEVLMSALSAMQDKNQHLENS---LSAEtRIKL-----DLFSALGDAKRQLEIAQGQIYQKDQEIKDLKQKIAEV 631
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 858-986 2.35e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.66  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   858 IIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEikvmKEQIQEMEAELE 937
Cdd:pfam13851   20 ITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKD----KQSLKNLKARLK 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568929692   938 RFHKQNTQLELNITELLQKLratdqemrkeQQKERDLEALVRRFKTDLH 986
Cdd:pfam13851   96 VLEKELKDLKWEHEVLEQRF----------EKVERERDELYDKFEAAIQ 134
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 502-1066 2.50e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 2.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   502 ENINILKGHTGKILREIPAFDVIYTSITISHSGRMIFVGTSVGTIRAMKYPLSLQKEYNEYQAHAGPVMKMLLTFDDQFL 581
Cdd:TIGR01612  292 EHAAITHEHIDAELNDIKKHPMINDKELRPHGKRLIKILESEGEQGHIINKLIFLEKEFEDTIHKSDIYKDECLSNHLFM 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   582 LT-VGEDGCLFTWKVFDKDGRGIKREREVGF--AEEVLVTKTDMEEKAQIMLELKTRVEELKMENeyqlrlKDMNYTEKI 658
Cdd:TIGR01612  372 EDyLKDDKISPYYYEFLEEIKKIAKQRAIFFynAKKLKHLEILYKHQEDILNNFHKTIERLIFEK------PDPNNNNIF 445

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   659 KELTDKFIQEMEslKTKNQVLKT---EKEKQDISHRErLEELVDKQTRelQDleccNNQKLLLEYEKyqELQLKSQRMqE 735
Cdd:TIGR01612  446 KDDFDEFNKPIP--KSKLKALEKrffEIFEEEWGSYD-IKKDIDENSK--QD----NTVKLILMRMK--DFKDIIDFM-E 513

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   736 EYEkqlRDNDETKSQALEELTEFYEAKL-QEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIqdiktKYERKLRDEK 814
Cdd:TIGR01612  514 LYK---PDEVPSKNIIGFDIDQNIKAKLyKEIEAGLKESYELAKNWKKLIHEIKKELEEENEDSI-----HLEKEIKDLF 585

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   815 ESNLRLKGETGIMRKKFSSLQKEIEERTNDIELLKsEQMKLQGIIRSLEKDIQGLKR--------EIQERDE---TIQDK 883
Cdd:TIGR01612  586 DKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIK-KAIDLKKIIENNNAYIDELAKispyqvpeHLKNKDKiysTIKSE 664

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   884 EKRIY--DLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNitellqKLRATD 961
Cdd:TIGR01612  665 LSKIYedDIDALYNELSSIVKENAIDNTEDKAKLDDLKSKIDKEYDKIQNMETATVELHLSNIENKKN------ELLDII 738

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   962 QEMRKEQQKE--RDLEALVRRFK-------TDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVEIAglNSDLQQEYARQ 1032
Cdd:TIGR01612  739 VEIKKHIHGEinKDLNKILEDFKnkekelsNKINDYAKEKDELNKYKSKISEIKNHYNDQINIDNIK--DEDAKQNYDKS 816

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 568929692  1033 REHlernlatLKKKVIKEGELHRT-DYVRIMQENV 1066
Cdd:TIGR01612  817 KEY-------IKTISIKEDEIFKIiNEMKFMKDDF 844
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 712-812 2.80e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 39.48  E-value: 2.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   712 NNQKLLLEYEKYQELQLKSQRMQEEYEKQLrdndETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLREFEETKKQI 791
Cdd:pfam03938    6 DMQKILEESPEGKAAQAQLEKKFKKRQAEL----EAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQKA 81

                           90       100
                   ....*....|....*....|.
gi 568929692   792 EEDEDREIQDIKTKYERKLRD 812
Cdd:pfam03938   82 QQELQKKQQELLQPIQDKINK 102
PRK01156 PRK01156
chromosome segregation protein; Provisional
 835-1147 2.82e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  835 QKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQglkrEIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQ 914
Cdd:PRK01156  151 RKKILDEILEINSLERNYDKLKDVIDMLRAEIS----NIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  915 IEPRENEIKVMKEQIQEMEAELERFHKQNTQlelnitellqkLRATDQEMRKEQQKERDLEALVRRFKtDLHNCVAYIQe 994
Cdd:PRK01156  227 YNNAMDDYNNLKSALNELSSLEDMKNRYESE-----------IKTAESDLSMELEKNNYYKELEERHM-KIINDPVYKN- 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  995 pgllKEKIRGLFEKYVQRADMVEI-AGLNSDLQQEYARQREhlernLATLKKkvikegelHRTDYVRIMQENVSLIKEIN 1073
Cdd:PRK01156  294 ----RNYINDYFKYKNDIENKKQIlSNIDAEINKYHAIIKK-----LSVLQK--------DYNDYIKKKSRYDDLNNQIL 356

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568929692 1074 ELRRELKLTRSQIYDLESalkVSKKTRSQEvpesvISKDVVGSTSTMRLNEQEETGRIIEMQRLEIRRLRDQIQ 1147
Cdd:PRK01156  357 ELEGYEMDYNSYLKSIES---LKKKIEEYS-----KNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDIS 422
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 692-939 3.37e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  692 ERLEELVDKqtreLQDLEccnnQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEELTEFYEAKLQEktglLE 771
Cdd:PRK00409  516 EKLNELIAS----LEELE----RELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKE----AK 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  772 EAQEDVRQQLREFEetKKQIEEDEDREIQDIKTKYERKLrDEKESNLRLKGETgimrkkfsslQKEIEErtND-IELLKS 850
Cdd:PRK00409  584 KEADEIIKELRQLQ--KGGYASVKAHELIEARKRLNKAN-EKKEKKKKKQKEK----------QEELKV--GDeVKYLSL 648

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  851 EQMklqGIIRSLEKDiqglkREIQERDETIQDKEKrIYDLKK-KNQELEKFKfvldyKIKELKKQIEPRENEIKVMKEQI 929
Cdd:PRK00409  649 GQK---GEVLSIPDD-----KEAIVQAGIMKMKVP-LSDLEKiQKPKKKKKK-----KPKTVKPKPRTVSLELDLRGMRY 714

                         250
                  ....*....|
gi 568929692  930 QEMEAELERF 939
Cdd:PRK00409  715 EEALERLDKY 724
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 728-902 3.41e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.16  E-value: 3.41e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692    728 LKSQRMQEEYEKQLRDNDEtksqalEELTEFYEAKLQEKTGLLEEAQE--DVRQQLRE-FEETKKQIEEdedreiqdikt 804
Cdd:smart00787  128 LEAKKMWYEWRMKLLEGLK------EGLDENLEGLKEDYKLLMKELELlnSIKPKLRDrKDALEEELRQ----------- 190

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692    805 kyERKLRDEKESNLrlKGETGIMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIqdKE 884
Cdd:smart00787  191 --LKQLEDELEDCD--PTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKL--EQ 264

                           170
                    ....*....|....*...
gi 568929692    885 KRIYDLKKKNQELEKFKF 902
Cdd:smart00787  265 CRGFTFKEIEKLKEQLKL 282
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 667-1103 3.96e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.21  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   667 QEMESLKTKNQVLKTEKEK--QDISHRERLEELVDKQTRELQDLEccnNQKLLLEYEKYQ------ELQLKSQRMQEEY- 737
Cdd:pfam05622   21 QQVSLLQEEKNSLQQENKKlqERLDQLESGDDSGTPGGKKYLLLQ---KQLEQLQEENFRletardDYRIKCEELEKEVl 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   738 EKQLRDNDETK----SQAL-EELTEFYEAklQEKTGLLEEAQEDVRQQLREFEETKKQIEEDEDREIQDIKTK--YERKL 810
Cdd:pfam05622   98 ELQHRNEELTSlaeeAQALkDEMDILRES--SDKVKKLEATVETYKKKLEDLGDLRRQVKLLEERNAEYMQRTlqLEEEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   811 RdeKESNLRLKGETgiMRKKFSSLQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQglkREIQERDEtiqdkekriydL 890
Cdd:pfam05622  176 K--KANALRGQLET--YKRQVQELHGKLSEESKKADKLEFEYKKLEEKLEALQKEKE---RLIIERDT-----------L 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   891 KKKNQELEKFKFVLDYKIKE---LKKQIEPRENEIKVM-----KEQIQEMEAELERFH-KQNTQLELNITELLQKLRATD 961
Cdd:pfam05622  238 RETNEELRCAQLQQAELSQAdalLSPSSDPGDNLAAEImpaeiREKLIRLQHENKMLRlGQEGSYRERLTELQQLLEDAN 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   962 Q-------EMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQRADMVE-----IAGLNSDLQQEY 1029
Cdd:pfam05622  318 RrkneletQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLEKLHEAQSELQkkkeqIEELEPKQDSNL 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1030 ARQREHLERNLaTLKKKVIKEGELHRTDYVRIMQE---------NVSLIKEINELRRELKLTRSQIYDLESALKVSKKTR 1100
Cdd:pfam05622  398 AQKIDELQEAL-RKKDEDMKAMEERYKKYVEKAKSviktldpkqNPASPPEIQALKNQLLEKDKKIEHLERDFEKSKLQR 476


                   ...
gi 568929692  1101 SQE 1103
Cdd:pfam05622  477 EQE 479
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 907-1152 4.28e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  907 KIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLH 986
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  987 ncvayiQEPGLLKEKIRGLFEkyvqradMVEIAGLNSDLQQEYARQrehLERNLATLKkkvikegelhrtdyvRIMQENV 1066
Cdd:COG4942   101 ------AQKEELAELLRALYR-------LGRQPPLALLLSPEDFLD---AVRRLQYLK---------------YLAPARR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692 1067 SLIKEINELRRELKLTRSQIydlesalkvskktrsqevpesviskdvvgststmrLNEQEETGRIIEMQRLEIRRLRDQI 1146
Cdd:COG4942   150 EQAEELRADLAELAALRAEL-----------------------------------EAERAELEALLAELEEERAALEALK 194


                  ....*.
gi 568929692 1147 QEQEQV 1152
Cdd:COG4942   195 AERQKL 200
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 657-783 5.09e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  657 KIKELTDKFIQEMES-----LKTKNQVLKTEKEKQdishrerleelVDKQTRELQDLEccnnQKLLLEYEKYQELQLKSQ 731
Cdd:cd16269   167 KAEEVLQEFLQSKEAeaeaiLQADQALTEKEKEIE-----------AERAKAEAAEQE----RKLLEEQQRELEQKLEDQ 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568929692  732 -RMQEEYEKQLRDN-DETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLRE 783
Cdd:cd16269   232 eRSYEEHLRQLKEKmEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQE 285
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 724-804 5.44e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 38.19  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  724 QELQLKSQRMQEEYEKQLRdndETKSQALEELTEFYEAKLQEKTGLLEEAQEDVRQQLrefEETKKQIEEDEDREIQDIK 803
Cdd:cd06503    43 EKAKEEAEELLAEYEEKLA---EARAEAQEIIEEARKEAEKIKEEILAEAKEEAERIL---EQAKAEIEQEKEKALAELR 116


                  .
gi 568929692  804 T 804
Cdd:cd06503   117 K 117
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 879-1047 6.07e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  879 TIQDKEKRIYDLkkknQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITElLQKLR 958
Cdd:COG1579     1 AMPEDLRALLDL----QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEE-VEARI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  959 ATDQEMRKEQQKERDLEALVRRfktdlhncVAYIQ-EPGLLKEKIRGLFEKY-VQRADMVEIAGLNSDLQQEYARQREHL 1036
Cdd:COG1579    76 KKYEEQLGNVRNNKEYEALQKE--------IESLKrRISDLEDEILELMERIeELEEELAELEAELAELEAELEEKKAEL 147

                         170
                  ....*....|.
gi 568929692 1037 ERNLATLKKKV 1047
Cdd:COG1579   148 DEELAELEAEL 158
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 909-976 7.40e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 37.94  E-value: 7.40e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692   909 KELKKQIEPRENEIKVMKEQIQEMEAELErfhKQNTQLELNITELLQKLRATDQEMRKEQQK-ERDLEA 976
Cdd:pfam03938   22 AQLEKKFKKRQAELEAKQKELQKLYEELQ---KDGALLEEEREEKEQELQKKEQELQQLQQKaQQELQK 87
PRK12704 PRK12704
phosphodiesterase; Provisional
 862-1052 7.87e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.15  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  862 LEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKiKELKKQIEPRENEIKVMKEQIQEMEAELERfhk 941
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLR-NEFEKELRERRNELQKLEKRLLQKEENLDR--- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  942 qntqlelnitellqKLRATDQEMRKEQQKERDLEALVRRFKTdlhncvayiqepglLKEKIRGLFEKYVQRadMVEIAGl 1021
Cdd:PRK12704  101 --------------KLELLEKREEELEKKEKELEQKQQELEK--------------KEEELEELIEEQLQE--LERISG- 149

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568929692 1022 nsdLQQEYARQR--EHLERNLATLKKKVIKEGE 1052
Cdd:PRK12704  150 ---LTAEEAKEIllEKVEEEARHEAAVLIKEIE 179
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 832-937 8.54e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 40.45  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  832 SSLQKEIEERTNDIELLKSEQMKLQGiirslEKDIQGLKREIQERDEtIQDKEKRIYDLKKKNQElEKfkfVLDYKIKEL 911
Cdd:COG0542   407 DSKPEELDELERRLEQLEIEKEALKK-----EQDEASFERLAELRDE-LAELEEELEALKARWEA-EK---ELIEEIQEL 476

                          90       100
                  ....*....|....*....|....*.
gi 568929692  912 KKQIEPRENEIKVMKEQIQEMEAELE 937
Cdd:COG0542   477 KEELEQRYGKIPELEKELAELEEELA 502
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 869-1102 8.59e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 40.26  E-value: 8.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   869 LKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRENEIKVMKEQIQEMEA---ELERFHKQNTQ 945
Cdd:pfam07888   36 LEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEkykELSASSEELSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   946 ----LELNITELLQKLRATDQEMRKEQQKERDLEALVRRFKTDLHNCVAYIQEPGLLKEKIRGLFEKYVQradmvEIAGL 1021
Cdd:pfam07888  116 ekdaLLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE-----ELRSL 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1022 NSDLQQ------EYARQREHLERNLATLKKKVikeGELHRTDyvrimQENVSLIKEINELRRELKLTRSQIYDLESALK- 1094
Cdd:pfam07888  191 SKEFQElrnslaQRDTQVLQLQDTITTLTQKL---TTAHRKE-----AENEALLEELRSLQERLNASERKVEGLGEELSs 262


                   ....*....
gi 568929692  1095 -VSKKTRSQ 1102
Cdd:pfam07888  263 mAAQRDRTQ 271
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 834-957 8.78e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 39.62  E-value: 8.78e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692    834 LQKEIEERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQElekfkfvldyKIKELKK 913
Cdd:smart00787  149 LDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDPTELDRAKE----------KLKKLLQ 218

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 568929692    914 QIEPRENEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKL 957
Cdd:smart00787  219 EIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKL 262
mukB PRK04863
chromosome partition protein MukB;
621-789 8.88e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.33  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  621 DMEEKAQIMLELKTRVEELKMEneyQLRLKdmnytEKIKELTDKFIQemeslktKNQVLKTEKekqdiSHRERLEELVDK 700
Cdd:PRK04863  979 MLAKNSDLNEKLRQRLEQAEQE---RTRAR-----EQLRQAQAQLAQ-------YNQVLASLK-----SSYDAKRQMLQE 1038

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  701 QTRELQDLEccnnqkllLEYEKYQELQLKSQRmqEEYEKQLRDNDETKSQALEELTeFYEAKLQEKTGLLEEAQEDVRQQ 780
Cdd:PRK04863 1039 LKQELQDLG--------VPADSGAEERARARR--DELHARLSANRSRRNQLEKQLT-FCEAEMDNLTKKLRKLERDYHEM 1107


                  ....*....
gi 568929692  781 LREFEETKK 789
Cdd:PRK04863 1108 REQVVNAKA 1116
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 605-882 9.36e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 9.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   605 REREVGFAEEVLVTKTDMEEKAQIML-ELKTRVEELKME-NEYQLRLKDMNYT----EKIKELTDKFIQEMESLKTK--N 676
Cdd:TIGR02168  752 LSKELTELEAEIEELEERLEEAEEELaEAEAEIEELEAQiEQLKEELKALREAldelRAELTLLNEEAANLRERLESleR 831

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   677 QVLKTEKEKQDISHR-ERLEELVDKQTRELQDLeccnnQKLLLEYEKYQELQLKSQRMQEEYEKQLRDNDETKSQALEEL 755
Cdd:TIGR02168  832 RIAATERRLEDLEEQiEELSEDIESLAAEIEEL-----EELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   756 tefyEAKLQEKTGLLEEAQEdvrqQLREFEETKKQIEEDEDREIQDIKTKYERKLRDEKESNLRLKGETGIMRKKFSSLQ 835
Cdd:TIGR02168  907 ----ESKRSELRRELEELRE----KLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLE 978

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568929692   836 KEI--------------EERTNDIELLKSEQMKLQGIIRSLEKDIQGLKREIQER-DETIQD 882
Cdd:TIGR02168  979 NKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERfKDTFDQ 1040
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
859-1080 9.37e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  859 IRSLEKDIQGLKReIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDyKIKELKKQIEPRENEIKV--MKEQIQEMEAEL 936
Cdd:COG4913   227 ADALVEHFDDLER-AHEALEDAREQIELLEPIRELAERYAAARERLA-ELEYLRAALRLWFAQRRLelLEAELEELRAEL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  937 ERFHKQNTQLELNITELLQKLRATDQEMR-----KEQQKERDLEALVRRfktdlhncvayiqepgllKEKIRGLFEKYVQ 1011
Cdd:COG4913   305 ARLEAELERLEARLDALREELDELEAQIRgnggdRLEQLEREIERLERE------------------LEERERRRARLEA 366

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568929692 1012 RADMVEIAGLNSdlQQEYARQREHLERNLATLKKkvikEGELHRTDYVRIMQENVSLIKEINELRRELK 1080
Cdd:COG4913   367 LLAALGLPLPAS--AEEFAALRAEAAALLEALEE----ELEALEEALAEAEAALRDLRRELRELEAEIA 429
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 855-1150 9.43e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.44  E-value: 9.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   855 LQGIIRSLEKDIQGLKREIQERDETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKKQIEPRE--------------- 919
Cdd:TIGR02169  140 LQGDVTDFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRrerekaeryqallke 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   920 ----------NEIKVMKEQIQEMEAELERFHKQNTQLELNITELLQKLRATDQEMRKEQQKERDL-EALVRRFKTDLH-- 986
Cdd:TIGR02169  220 kreyegyellKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGel 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692   987 -----NCVAYIQEPGLLKEKIRGLFEKYVQRADMV--EIAGLNSDLqQEYARQREHLERNLATLKK-------KVIKEGE 1052
Cdd:TIGR02169  300 eaeiaSLERSIAEKERELEDAEERLAKLEAEIDKLlaEIEELEREI-EEERKRRDKLTEEYAELKEeledlraELEEVDK 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568929692  1053 LHRTDYVRIMQENV---SLIKEINELRRE-------LKLTRSQIYDLESALKvSKKTRSQEVPESVISKDVVGSTSTMRL 1122
Cdd:TIGR02169  379 EFAETRDELKDYREkleKLKREINELKREldrlqeeLQRLSEELADLNAAIA-GIEAKINELEEEKEDKALEIKKQEWKL 457

                          330       340
                   ....*....|....*....|....*...
gi 568929692  1123 neqEETGRIIEMQRLEIRRLRDQIQEQE 1150
Cdd:TIGR02169  458 ---EQLAADLSKYEQELYDLKEEYDRVE 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH