NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568928150|ref|XP_006502694|]
View 

doublecortin domain-containing protein 2B isoform X1 [Mus musculus]

Protein Classification

ubiquitin family protein( domain architecture ID 1000087)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 123-201 2.41e-44

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17153:

Pssm-ID: 475130  Cd Length: 80  Bit Score: 146.82  E-value: 2.41e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17153    1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFK 79
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 4-82 1.55e-41

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17150:

Pssm-ID: 475130  Cd Length: 79  Bit Score: 139.55  E-value: 1.55e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17150    1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
 
Name Accession Description Interval E-value
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 123-201 2.41e-44

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 146.82  E-value: 2.41e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17153    1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFK 79
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 4-82 1.55e-41

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 139.55  E-value: 1.55e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17150    1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 3-86 6.63e-26

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 98.87  E-value: 6.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150     3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAV--QAPLAVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERF 80
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVklDLPHGVRKLYTL-DGKKVTSLDELEDGGSYVASGTEAF 83


                   ....*.
gi 568928150    81 HKIHYL 86
Cdd:smart00537  84 KKVDYG 89
DCX pfam03607
Doublecortin;
22-80 3.45e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 79.80  E-value: 3.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568928150   22 VVTQRRYPTMEALLYEVTSAVQ-APL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERF 80
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVkLPFgAVRKLYTL-DGKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
143-200 6.10e-16

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 70.94  E-value: 6.10e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150  143 LSQTAIQDWDTVLKLLSEKV-TLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEF 200
Cdd:pfam03607   2 VNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 123-205 3.22e-13

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 64.59  E-value: 3.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSG-AVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84


                   ....
gi 568928150   202 ALPY 205
Cdd:smart00537  85 KVDY 88
 
Name Accession Description Interval E-value
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 123-201 2.41e-44

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 146.82  E-value: 2.41e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17153    1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFK 79
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 4-82 1.55e-41

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 139.55  E-value: 1.55e-41
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17150    1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 4-82 2.02e-35

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 123.49  E-value: 2.02e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAP-LAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17071    1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPfGAVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSERFKK 80
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 123-196 5.45e-32

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 114.60  E-value: 5.45e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVG 196
Cdd:cd16113    1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGAVRKLYTLDGKRISDPDELVNGGQYVAVG 74
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 4-82 4.48e-27

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 101.79  E-value: 4.48e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17151    1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 4-82 4.60e-27

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 101.78  E-value: 4.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPL-AVRVLYTLSDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17149    1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFgAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 3-86 6.63e-26

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 98.87  E-value: 6.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150     3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAV--QAPLAVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERF 80
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVklDLPHGVRKLYTL-DGKKVTSLDELEDGGSYVASGTEAF 83


                   ....*.
gi 568928150    81 HKIHYL 86
Cdd:smart00537  84 KKVDYG 89
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 123-201 3.99e-25

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 96.79  E-value: 3.99e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17152    1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFK 79
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 123-202 8.07e-24

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 93.34  E-value: 8.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFKA 202
Cdd:cd17154    1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFKA 80
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 3-76 1.88e-20

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 83.78  E-value: 1.88e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568928150   3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAG 76
Cdd:cd16113    1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTgAVRKLYTL-DGKRISDPDELVNGGQYVAVG 74
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 4-76 5.80e-20

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 82.66  E-value: 5.80e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQ-APLAVRVLYTLSdGHPVTNLADLQNGGQYVAAG 76
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGlPTGGVRKLYTPS-GKLVKSLSDLEDGESYVVCG 73
DCX pfam03607
Doublecortin;
22-80 3.45e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 79.80  E-value: 3.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568928150   22 VVTQRRYPTMEALLYEVTSAVQ-APL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERF 80
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVkLPFgAVRKLYTL-DGKRVTSLDELEDGGVYVAAGREKF 60
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 3-82 2.78e-17

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 75.80  E-value: 2.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSA----VQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFE 78
Cdd:cd16109    2 AKKVRFYRNGDRFFKGIVYAVSSERFRSFEALLADLTRSlsdnVNLPQGVRTIFTIDGSRKITSLDELEDGESYVCASTD 81


                 ....
gi 568928150  79 RFHK 82
Cdd:cd16109   82 AFKK 85
DCX1_RP_like cd16110
Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 4-74 5.15e-16

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340527  Cd Length: 75  Bit Score: 71.95  E-value: 5.15e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVA 74
Cdd:cd16110    1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFGVRSITTPRGRHSITSLEQLEDGGKYVC 71
DCX pfam03607
Doublecortin;
143-200 6.10e-16

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 70.94  E-value: 6.10e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150  143 LSQTAIQDWDTVLKLLSEKV-TLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEF 200
Cdd:pfam03607   2 VNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 3-85 5.19e-14

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 66.95  E-value: 5.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSA----VQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFE 78
Cdd:cd17140    2 AKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTlsdnVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIE 81


                 ....*..
gi 568928150  79 RFHKIHY 85
Cdd:cd17140   82 PFKKLEY 88
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 3-82 1.64e-13

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 65.31  E-value: 1.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSA----VQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFE 78
Cdd:cd17141    2 AKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTRSlsdnVNLPQGVRTIYTIDGSKKITSLDELLEGESYVCASNE 81


                 ....
gi 568928150  79 RFHK 82
Cdd:cd17141   82 PFRK 85
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 123-205 3.22e-13

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 64.59  E-value: 3.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSG-AVHKLCTLEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84


                   ....
gi 568928150   202 ALPY 205
Cdd:smart00537  85 KVDY 88
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 126-196 3.58e-12

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 61.09  E-value: 3.58e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568928150 126 IHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALVNGHYYVAVG 196
Cdd:cd01617    3 ITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX1_DCX cd16112
Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 3-85 2.32e-11

Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340529  Cd Length: 89  Bit Score: 59.54  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   3 AKRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSA----VQAPLAVRVLYTLSDGHPVTNLADLQNGGQYVAAGFE 78
Cdd:cd16112    2 AKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSlsdnINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDN 81


                 ....*..
gi 568928150  79 RFHKIHY 85
Cdd:cd16112   82 FFKKVEY 88
DCX1_RP1 cd17145
Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also ...
 4-73 3.48e-11

Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors and is required for correct stacking of outer segment discs. It interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340665  Cd Length: 79  Bit Score: 58.67  E-value: 3.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYV 73
Cdd:cd17145    1 KRVCFYKSGDPQFGGLRMVVNSRSFKTFDALLDNLSKKVPLPFGVRNITTPRGVHHITSLEDLEDGKSYI 70
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 126-201 2.47e-09

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 53.38  E-value: 2.47e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568928150 126 IHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLE-GLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17071    3 IVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGAVRSIYTPTgGHRVKDLDSLQNGGVYVAAGSERFK 79
DCX2_RP1 cd17147
Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed ...
 4-80 5.05e-09

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340667  Cd Length: 76  Bit Score: 52.45  E-value: 5.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   4 KRILVYRNGDaffPG--HQLVVTQRRYPTMEALLYEVTSAVQAPlaVRVLYTlSDGHPVTNL-ADLQNGGQYVAAGFERF 80
Cdd:cd17147    1 RKLIVFKNGD---PGfkHTLILNKKTTQSFEALLDHVSELMQFP--VVKLYT-TDGRRVDSLqALILSSGAVVAAGREPF 74
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 4-73 1.55e-08

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 50.98  E-value: 1.55e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150   4 KRILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPLAVRVLYTLSDGHPVTNLADLQNGGQYV 73
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYL 70
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 6-82 2.19e-08

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 50.57  E-value: 2.19e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568928150   6 ILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17152    4 IFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTgAVRRLYTL-DGKLINDGSELENGQFYVAVGREKFKK 80
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 6-82 3.64e-08

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 50.13  E-value: 3.64e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568928150   6 ILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERFHK 82
Cdd:cd17153    4 IHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTgAVRKLCTL-DGVPLSSGKELVSGQYYVAVGSEKFKD 80
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 5-63 5.77e-07

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 46.54  E-value: 5.77e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568928150   5 RILVYRNGDAFFPGHQLVVTQrrypTMEALLYEVTSAVQAPLAVRVLYTlSDGHPVTNL 63
Cdd:cd17158    2 KILAYKNGEGRLRDGVLIIGS----TFPGLLDQCTHRLGLARAARRLYT-ADGTLILTL 55
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 6-80 4.86e-06

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 44.03  E-value: 4.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568928150   6 ILVYRNGDAFFPGHQLVVTQRRYPTMEALLYEVTSAVQAPL-AVRVLYTLsDGHPVTNLADLQNGGQYVAAGFERF 80
Cdd:cd17154    4 INVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTgGVFRLCTL-NGHPVSDSTELEDNHYYVAVGSEKF 78
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 4-75 2.51e-05

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 41.85  E-value: 2.51e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568928150   4 KRILVYRNGDAFFPgHQLVVTQRRYPTMEALLYEVTSAVQAPlaVRVLYTLsDGHPVTNLADLQNG-GQYVAA 75
Cdd:cd17070    1 KVITVISNGDPHSR-HTILLNRRTTQSFEQVLQDLSELLKGP--VRKLYTT-DGKKVESLSALFHGpDEYVAA 69
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 126-201 5.89e-04

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 38.22  E-value: 5.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568928150 126 IHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCT-LEGLPLSTGTALVNGHYYVAVGEEEFK 201
Cdd:cd17149    3 VLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTpRGGHRVRSLEQLQSGEQYVAAGRERFK 79
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 4-68 4.11e-03

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 35.33  E-value: 4.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568928150   4 KRILVYRNGDAFFP-GHQLVVTQrryPTMEALLYEVTSAVQAPLAVRVLYTLsDGHPVTNLADLQN 68
Cdd:cd17072    1 VRLRVLKNGERDLErAVYVVGPD---LELQLFLDRCTERLNLPFAARRLFDE-NGKEIFTLRDLER 62
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 4-67 5.98e-03

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 34.96  E-value: 5.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568928150   4 KRILVYRNGDAffpghqlvVTQRRY---PTMEALLYEVTSAVQAPLAVRVLYTLsDGHPVTNLADLQ 67
Cdd:cd17159    1 KRVLVYPNGGS--------PERAVYawgKSIEELLDSCTERLGLRKPAKYLYTP-DGEQIQSWDDIE 58
DCX2_DCLK2 cd17144
Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 123-201 8.01e-03

Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in double tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK2 members regulate cyclic AMP signaling. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340664  Cd Length: 84  Bit Score: 35.00  E-value: 8.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928150 123 PCYIHVFRNGDLLSPPFSLKLSQTAIQDWDTVLKLLSEKVTLQSGAVHKLCTLEGLPLSTGTALV-NGHYYVAVGEEEFK 201
Cdd:cd17144    4 PKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFgDDDVFIACGPEKYR 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH