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Conserved domains on  [gi|568924491|ref|XP_006502353|]
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B-cell CLL/lymphoma 9 protein isoform X1 [Mus musculus]

Protein Classification

BCL9 and PHA03247 domain-containing protein( domain architecture ID 10568824)

BCL9 and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 570-1160 7.32e-15

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 7.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  570 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGVFSGPGRGERFPnPQGLSEEMFQQQLAEKQLALPPGMSME 649
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  650 GIRPGMEmNRMIPGSQ---RHMEPG-----------SNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGm 715
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  716 kgevNLNVNMGSSSQMIPQKMREAGAGPEEMMKLRpgssemlpAQQKMVPLPFGEHPQqeygvGPRPflpmsqgpgsnsg 795
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  796 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLSTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 875
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  876 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 955
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  956 ASPAmlGSVESGGPPPPTASQPASVnIPGSLPSSTPYPMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1035
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1036 DDSPPARSPNLPsmnsmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAMGPSIPPHGVPmgpglmsh 1115
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 568924491 1116 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGG 1160
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 1.40e-09

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


:

Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 54.71  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568924491   350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 570-1160 7.32e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 7.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  570 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGVFSGPGRGERFPnPQGLSEEMFQQQLAEKQLALPPGMSME 649
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  650 GIRPGMEmNRMIPGSQ---RHMEPG-----------SNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGm 715
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  716 kgevNLNVNMGSSSQMIPQKMREAGAGPEEMMKLRpgssemlpAQQKMVPLPFGEHPQqeygvGPRPflpmsqgpgsnsg 795
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  796 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLSTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 875
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  876 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 955
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  956 ASPAmlGSVESGGPPPPTASQPASVnIPGSLPSSTPYPMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1035
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1036 DDSPPARSPNLPsmnsmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAMGPSIPPHGVPmgpglmsh 1115
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 568924491 1116 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGG 1160
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 1.40e-09

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 54.71  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568924491   350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 1095-1181 5.97e-04

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 42.56  E-value: 5.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  1095 NAMGPSIPPHGVPMGPglMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGGQGNFPGGIGFPGEG 1174
Cdd:pfam04959  111 DAKRPATPELKPKPPP--RPANRRERPGRAFPSQRPQGQMSDGHPRPPMDGPGGGPPFPPNQYGGGRGNYDNFRGQGGGG 188


                   ....*..
gi 568924491  1175 PLGRPSN 1181
Cdd:pfam04959  189 YPPKPRD 195
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 570-1160 7.32e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 7.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  570 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGVFSGPGRGERFPnPQGLSEEMFQQQLAEKQLALPPGMSME 649
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  650 GIRPGMEmNRMIPGSQ---RHMEPG-----------SNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGm 715
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  716 kgevNLNVNMGSSSQMIPQKMREAGAGPEEMMKLRpgssemlpAQQKMVPLPFGEHPQqeygvGPRPflpmsqgpgsnsg 795
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  796 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLSTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 875
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  876 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 955
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  956 ASPAmlGSVESGGPPPPTASQPASVnIPGSLPSSTPYPMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1035
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1036 DDSPPARSPNLPsmnsmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAMGPSIPPHGVPmgpglmsh 1115
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 568924491 1116 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGG 1160
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
 772-1201 7.20e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.20  E-value: 7.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  772 PQQEYGVGPRPFLPMSQGPGSNSglrNLREPIGPDQRTNSRL----SHMPPLPLNPSSNPTSLSTAPPVQRGLGRKPLDI 847
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPSEPAVTS---RARRPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  848 SVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIksppvlgSAAASPVHLKSPSLPA 927
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-------TSLADPPPPPPTPEPA 2711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  928 PSPGWTSSPKPPLQSPGIPPNHKAPLTMASPamlgsvesggPPPPTASQPASVNIPGS--LPSSTPYPMPPeptlsqnpl 1005
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPP----------AVPAGPATPGGPARPARppTTAGPPAPAPP--------- 2772

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1006 simmsrmskfAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNSMPGMGINTQNPRISGPNPVVPMPTLSPMgmTQPL 1085
Cdd:PHA03247 2773 ----------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP--TAPP 2840

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1086 SHSNQMPSPNAMGPSIPPHG----------VPMGPGLMSHNPIMghgSQEPPMVPQGRMGFPQgfPPVQSPPQQVPFPHN 1155
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGdvrrrppsrsPAAKPAAPARPPVR---RLARPAVSRSTESFAL--PPDQPERPPQPQAPP 2915

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 568924491 1156 GPTGGQGNFPGGIGFPGEGPLGRPSNLPQSSADPALCKPGGPGAPD 1201
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961
PHA03247 PHA03247
large tegument protein UL36; Provisional
 907-1354 1.60e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  907 PPVLGSAAASPVHLKS--PSLPAPSPgwtssPKPPLQS----PGIPPNHKAPLTMASPamlgSVESGGPPPPTASQPASV 980
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSvpPPRPAPRP-----SEPAVTSrarrPDAPPQSARPRAPVDD----RGDPRGPAPPSPLPPDTH 2622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  981 niPGSLPSSTPYPMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARsPNLPSMNSMPGMGINTQ 1060
Cdd:PHA03247 2623 --APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR-PRRRAARPTVGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1061 NPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPSIPPhGVPMGPGLmshnpimgHGSQEPPMVPQGRMGFPQGF 1140
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPAT--------PGGPARPARPPTTAGPPAPA 2770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1141 PP---VQSPPQQVPFPHNGPTGGQGNFPGGIGFPGEGPLGRPsnlPQSSADPALCKPGGPGAPDSFTVlgnSMPSVFTDP 1217
Cdd:PHA03247 2771 PPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL---APAAALPPAASPAGPLPPPTSAQ---PTAPPPPPG 2844

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1218 DLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMSDQAPRMGLALPGMGGPGPVG 1297
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568924491 1298 TPDIPLGTSPSMPGHNPMRPPAFLQQGMMGPHHRMMSP-----AQSTVPGPATLMTNPAAAV 1354
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgalVPGRVAVPRFRVPQPAPSR 2986
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 1.40e-09

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 54.71  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568924491   350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
888-1124 9.94e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 9.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  888 PSQLAGMlAGPAAAASI----KSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAmlgS 963
Cdd:PRK12323  365 PGQSGGG-AGPATAAAApvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQA---S 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  964 VESGGPPPPTASQPASVNIPGSLPSSTPyPMPPEPTLSQNPLSIMMSRMSKfAMPSSTPLYHDAIKTVASsddDSPPARS 1043
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAG-PRPVAAAAAAAPARAAPAAAPA-PADDDPPPWEELPPEFAS---PAPAQPD 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1044 PNLPSMNSMPGMGINTQNPRISGPnPVVPMPTLSPMGMTQPLSHSNQMPSPNAMG-PSIPPHGVPMGPGLMSHNPIMGHG 1122
Cdd:PRK12323  516 AAPAGWVAESIPDPATADPDDAFE-TLAPAPAAAPAPRAAAATEPVVAPRPPRASaSGLPDMFDGDWPALAARLPVRGLA 594


                  ..
gi 568924491 1123 SQ 1124
Cdd:PRK12323  595 QQ 596
PHA03247 PHA03247
large tegument protein UL36; Provisional
 917-1372 3.24e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  917 PVHLKSPSLPAPSPGWTSSPKPPLQSPGiPPNHKAPLTMAS--------PAM---------LGSVESGGPPPPTASQPAS 979
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGPPDPDAPP-APSRLAPAILPDepvgepvhPRMltwirgleeLASDDAGDPPPPLPPAAPP 2561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  980 VNIPGSLPSSTPYPMPPEPTLSqnplsimmsrmSKFAMPSSTPlyHDAIKTVASSDDDSPPARSPnlpsmnsmpgmgint 1059
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPSEPAVT-----------SRARRPDAPP--QSARPRAPVDDRGDPRGPAP--------------- 2613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1060 qnprisgPNPVVPMPTlspmgmtqplshsnqMPSPNAMGPSIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG 1139
Cdd:PHA03247 2614 -------PSPLPPDTH---------------APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG 2671

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1140 FPPVQSPPQQVPFPHNGPTGgQGNFPGGIGFPGEGPLGRPSNLPQSSADPALCKPGGPGAPDSFTVLGNSMPSVFTDPDL 1219
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARPT-VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491 1220 qevirPGAtgipefdlsriiPSEKPSQTLQYFPRGEVPGRKQPQGPGPgfshmqgmmsdQAPRMGLAlpgmggpgpvgtp 1299
Cdd:PHA03247 2751 -----PGG------------PARPARPPTTAGPPAPAPPAAPAAGPPR-----------RLTRPAVA------------- 2789

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568924491 1300 diplGTSPSMPGHNPMRPPAFLQQGMMGPhhrmmSPAQSTVPGPATLMTNPAAAVGMIPGKDRGPAGLYTHPG 1372
Cdd:PHA03247 2790 ----SLSESRESLPSPWDPADPPAAVLAP-----AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 1095-1181 5.97e-04

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 42.56  E-value: 5.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  1095 NAMGPSIPPHGVPMGPglMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGGQGNFPGGIGFPGEG 1174
Cdd:pfam04959  111 DAKRPATPELKPKPPP--RPANRRERPGRAFPSQRPQGQMSDGHPRPPMDGPGGGPPFPPNQYGGGRGNYDNFRGQGGGG 188


                   ....*..
gi 568924491  1175 PLGRPSN 1181
Cdd:pfam04959  189 YPPKPRD 195
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 845-1093 9.61e-04

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 43.67  E-value: 9.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   845 LDISVAGSQVHSPGINPLKSPTMHQVQSpmlGSPSGNLKSPqtPSQLAGMLAGPAAAASIKSPPVLGSAAA-SPVHLKSP 923
Cdd:pfam08580  418 EDSPATLVANKTPGSSPPSSVIMTPVNK---GSKTPSSRRG--SSFDFGSSSERVINSKLRRESKLPQIAStLKQTKRPS 492

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   924 SLPAPSPgwtssPKPPLQSPgiPPNhkaPLTMASPAMLGSVESGGPPPPTASQPASVNIPGSLPSSTPYPMPPEPTLSQN 1003
Cdd:pfam08580  493 KIPRASP-----NHSGFLST--PSN---TATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPS 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  1004 PLSIMMSRmSKFAMPSSTPLYHDAiktvasSDDDSPPARSPnlpsmnSMPGMGINTQNP-RISGPNPvvPMPTLSPMGMT 1082
Cdd:pfam08580  563 PTPSRSSR-SSSTLPPVSPLSRDK------SRSPAPTCRSV------SRASRRRASRKPtRIGSPNS--RTSLLDEPPYP 627

                          250
                   ....*....|.
gi 568924491  1083 QpLSHSNQMPS 1093
Cdd:pfam08580  628 K-LTLSKGLPR 637
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 877-1001 1.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 43.52  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  877 SPSGNLKSPQTPSQLAGMLAGpaAAASIKSPPVLGSAAASPVHLKSPSLPAP-SPGWTSSPKPPLQSPGIPPnhkAPltm 955
Cdd:PRK14959  372 RPSGGGASAPSGSAAEGPASG--GAATIPTPGTQGPQGTAPAAGMTPSSAAPaTPAPSAAPSPRVPWDDAPP---AP--- 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568924491  956 aspamlgsVESGGPPPPTASQPASVNIPGSlPSSTPYPMPPEPTLS 1001
Cdd:PRK14959  444 --------PRSGIPPRPAPRMPEASPVPGA-PDSVASASDAPPTLG 480
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 892-998 2.79e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  892 AGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGSVESGGPPP 971
Cdd:PRK14951  369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALA 448

                          90       100
                  ....*....|....*....|....*..
gi 568924491  972 PTASQPASVNIPGSLPSSTPYPMPPEP 998
Cdd:PRK14951  449 PAPPAQAAPETVAIPVRVAPEPAVASA 475
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 751-1048 3.27e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  751 PGSSEMLPAQQKMVPLPFGEHPQQEyGVGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSL 830
Cdd:PHA03307   73 PGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAAS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  831 STAPPVQRGlgrkpldiSVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTpsqlagmlAGPAAAASIKSPPVL 910
Cdd:PHA03307  152 PPAAGASPA--------AVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPA--------AASPRPPRRSSPISA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  911 GSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPN-----HKAPLTMASPAMLGSV-ESGGPPPPTASQPASVNIPG 984
Cdd:PHA03307  216 SASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENecplpRPAPITLPTRIWEASGwNGPSSRPGPASSSSSPRERS 295

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568924491  985 SLPSSTPYPMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPS 1048
Cdd:PHA03307  296 PSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPP 359
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
885-1079 3.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  885 PQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGSV 964
Cdd:PRK12323  387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAA 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  965 ESGGPPPPTASQPASVNIPGSLPSSTPYPMPPEPTLSQNPLSIMMSRMSkfamPSSTPLYHDAIKTVASSDDDSPPARSP 1044
Cdd:PRK12323  467 AGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD----AAPAGWVAESIPDPATADPDDAFETLA 542

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568924491 1045 NLPSMNSMPGMGINTQnPRISGPNPVVPMPTLSPM 1079
Cdd:PRK12323  543 PAPAAAPAPRAAAATE-PVVAPRPPRASASGLPDM 576
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 892-1023 4.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  892 AGMLAGPAAAASIKSPPVLGSAAASPVhlkspslPAPSPGWTSSPKPPLQSPGIPpnhkAPLTMASPAMLGSVESGGPPP 971
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAAPV-------AQAAAAPAPAAAPAAAASAPA----APPAAAPPAPVAAPAAAAPAA 436

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568924491  972 PTASQPASVNIPGSLPSSTPYPMPPEPTLSQNPLSIMMSRMSKFAMPSSTPL 1023
Cdd:PRK14951  437 APAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARL 488
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 885-998 4.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  885 PQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGSV 964
Cdd:PRK14951  371 EAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPA 450

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568924491  965 ESGGPPPPTASQPASVNIPGSLPSSTPYPMPPEP 998
Cdd:PRK14951  451 PPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPA 484
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 921-1101 5.73e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 5.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   921 KSPSLPAPSPGW-TSSPKPPLQSPGIPPNHKAPLTMASPAmlgsveSGGPPPPTA--SQPASVNIPGSLPSSTPYPMPPE 997
Cdd:pfam05109  423 KAPESTTTSPTLnTTGFAAPNTTTGLPSSTHVPTNLTAPA------STGPTVSTAdvTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   998 PTlSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNSMPGMGINTQNPRISGPNPVVPMPTLs 1077
Cdd:pfam05109  497 NG-TESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTL- 574

                          170       180
                   ....*....|....*....|....
gi 568924491  1078 pmGMTQPLShSNQMPSPNAMGPSI 1101
Cdd:pfam05109  575 --GKTSPTS-AVTTPTPNATSPTV 595
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 644-959 8.73e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 40.76  E-value: 8.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   644 PGMSMEGIRPGMeMNRMIPGSQRHMEPGSNPIFPRIPveGPLSPSRGDFPKGMPPQIGPGrelefgMVPGGMKGEVNLNV 723
Cdd:pfam09606  151 PGGQAGGMMQPS-SGQPGSGTPNQMGPNGGPGQGQAG--GMNGGQQGPMGGQMPPQMGVP------GMPGPADAGAQMGQ 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   724 NMGSSSQMIPQKMreAGAGPEEMMKLRPGSSEMLPAQQKMVPLPFGEHPQQEYGVGPR-----PFLPMSQGPGS-----N 793
Cdd:pfam09606  222 QAQANGGMNPQQM--GGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQggpgqPMGPPGQQPGAmpnvmS 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   794 SGLRNLREPIGPDQRTNSRLSHMPP-------LPLNPSSNPTSLSTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPT 866
Cdd:pfam09606  300 IGDQNNYQQQQTRQQQQQQGGNHPAahqqqmnQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPV 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491   867 MHQVQSPMlgspSGNLKSPQTPSQLagmLAGPAAAASIKSPPVLGSAAASPVHLKSPSlPAPSPGWTSSPKPPLQSPGIP 946
Cdd:pfam09606  380 PGQQVRQV----TPNQFMRQSPQPS---VPSPQGPGSQPPQSHPGGMIPSPALIPSPS-PQMSQQPAQQRTIGQDSPGGS 451

                          330
                   ....*....|...
gi 568924491   947 PNHKAPLTMASPA 959
Cdd:pfam09606  452 LNTPGQSAVNSPL 464
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
876-1048 9.55e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 9.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  876 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGwTSSPKPPLQSPGIPPNHKAPLTM 955
Cdd:PRK07003  365 GGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAA-TRAEAPPAAPAPPATADRGDDAA 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924491  956 ASPAMLGS-----VESGGPPPPTASQPASVNIPGSLP-SSTPYPMPPEPTLSQNPlsimmsrmskfAMPSSTPLYHDAIK 1029
Cdd:PRK07003  444 DGDAPVPAkanarASADSRCDERDAQPPADSGSASAPaSDAPPDAAFEPAPRAAA-----------PSAATPAAVPDARA 512

                         170
                  ....*....|....*....
gi 568924491 1030 TVASSDDDSPPARSPNLPS 1048
Cdd:PRK07003  513 PAAASREDAPAAAAPPAPE 531
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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