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Conserved domains on  [gi|568924287|ref|XP_006502252|]
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leucine-rich repeat and IQ domain-containing protein 3 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.40e-10

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568924287  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886  169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.40e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568924287  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886  169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-124 1.01e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPdkNFwSGLKNLKLLYLHDNgfsklkNI 115
Cdd:cd21340   10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGN------RI 80

                         90
                 ....*....|..
gi 568924287 116 CVLSG---CVSL 124
Cdd:cd21340   81 SVVEGlenLTNL 92
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568924287   51 SLRVCIFSNNFLTDIQP--LQSCKKLIKLDLHGNQIKTLPDKNFWsGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.40e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886   89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568924287  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886  169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-135 5.33e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 5.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287  44 ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHGNQIKTLPDknfWSGLKNLKLLYLHDNGFSKLKNICVLSgcv 122
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPPLANLT--- 272

                         90
                 ....*....|...
gi 568924287 123 SLIGLTMFDCPVS 135
Cdd:COG4886  273 NLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-124 1.01e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPdkNFwSGLKNLKLLYLHDNgfsklkNI 115
Cdd:cd21340   10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGN------RI 80

                         90
                 ....*....|..
gi 568924287 116 CVLSG---CVSL 124
Cdd:cd21340   81 SVVEGlenLTNL 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-113 3.60e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 3.60e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568924287  40 LKSMENLQTcisLRVcifSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDknfWSGLKNLKLLYLHDNGFSKLK 113
Cdd:COG4886  224 LANLTNLET---LDL---SNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQLTDLK 288
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568924287   51 SLRVCIFSNNFLTDIQP--LQSCKKLIKLDLHGNQIKTLPDKNFWsGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-124 5.99e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 5.99e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568924287  57 FSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDKNFwsgLKNLKLLYLHDNGFSKLKNicvLSGCVSL 124
Cdd:cd21340    9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF---LTNLTHLYLQNNQIEKIEN---LENLVNL 70
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 51-89 5.64e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 5.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568924287   51 SLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGN-QIKTLPD 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 51-169 6.05e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287  51 SLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIktlpdknfwsglknlkllylhdngfSKLKNIC-VLSGCVSLIGLTM 129
Cdd:cd21340  121 SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI-------------------------SDLEELLdLLSSWPSLRELDL 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568924287 130 FDCPVSLKKGYRHVLVNSIWPLKALDHHVISDEEI--IQNWR 169
Cdd:cd21340  176 TGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERqfLKRLK 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-128 6.09e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568924287  40 LKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDKNFWSGLKNLKLLYLHDNGFSKLKNICVLS 119
Cdd:COG4886  240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319


                 ....*....
gi 568924287 120 GCVSLIGLT 128
Cdd:COG4886  320 LTTLLLLLL 328
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-120 1.51e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568924287   72 KKLIKLDLHGNQIKTLPdknFWSGLKNLKLLYLHDNgfSKLKNICVLSG 120
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP---PLAKLPNLETLDLSGN--NKITDLSDLAN 44
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-88 1.03e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568924287  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDI----QPLQSCKKLIKLDLHGNQIKTLP 88
Cdd:cd21340  128 SGNNIDSLEPLAPLRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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