|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
116-1027 |
1.67e-165 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 508.56 E-value: 1.67e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 116 TQLGSQFSSMQINSYGVGATPQSQGPP-----GPQSAGAFQGPPQPAQPSILQPGHQ----VPPPPPTALNGPGASPMSP 186
Cdd:COG5028 2 SQHKKGVYPQAQSQVHTGAASSKKSARphrayANFSAGQMGMPPYTTPPLQQQSRRQidqaATAMHNTGANNPAPSVMSP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 187 pthrqdglpgpaplnaqyqpppppgqtlgpgYPPQQatnygpqmggaqMSYPGGFPGGPAQMAGPAPQLQrkldpdSIPS 266
Cdd:COG5028 82 -------------------------------AFQSQ------------QKFSSPYGGSMADGTAPKPTNP------LVPV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 267 piqVIENDRATRGGQVYTTnTRGQVPPLvTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPN 346
Cdd:COG5028 113 ---DLFEDQPPPISDLFLP-PPPIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPE 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 347 ETPLYLVNHGEsgPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVA 426
Cdd:COG5028 188 EDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 427 TLDYcrKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPkeEHEETSaiRVGFITYNKVLHFFNVKSNLaQP 506
Cdd:COG5028 266 PKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIP--NFDPRT--KIAIICFDSSLHFFKLSPDL-DE 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 507 QMMVVTDVGEVFVPLLDG-FLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPviqagmeALKAA-----ECPGKLFIF 580
Cdd:COG5028 339 QMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVF 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 581 HSSLPTAeAPGKLKNRDDKklvntdkEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYK 660
Cdd:COG5028 412 LSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYF 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 661 YNVFQIHS--DSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLS 738
Cdd:COG5028 484 YPNFSATRpnDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 739 EDvGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLA 818
Cdd:COG5028 564 TS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILK 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 819 CYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTL--- 895
Cdd:COG5028 643 AYKKELVKSNTSTQLPLPANLKLLPLLMLALLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpie 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 896 ----DVKSAALPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLR 971
Cdd:COG5028 722 aglpDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVR 801
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 568923964 972 MIMNNIQQKKPYS-MKLIVVKQ--REQREMAFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028 802 NIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
437-696 |
6.07e-114 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 351.58 E-value: 6.07e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEheetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKaaECPGKLFIFHSSLPTAEApGKLKNR 596
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 597 DDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYnvfqihsdsQRFLTD 676
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYY---------PSFNFS 224
|
250 260
....*....|....*....|
gi 568923964 677 LRNDIEKKIGFDAIMRVRTS 696
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
437-681 |
9.06e-107 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 332.29 E-value: 9.06e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPR-----ARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEAPGKLKNR 596
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 597 DDKKLVNTDKEKILFQPQT-AVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFLT 675
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 568923964 676 DLRNDI 681
Cdd:pfam04811 236 DLQRYF 241
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
439-1025 |
2.79e-48 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 187.97 E-value: 2.79e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 439 PPAFIFMIDVSYSNIKNGLVKLICEELKTALK--RLPKeeheetsaIRVGFITYNKVLHFFNVKSNLAQP---------- 506
Cdd:PTZ00395 952 PPYFVFVVECSYNAIYNNITYTILEGIRYAVQnvKCPQ--------TKIAIITFNSSIYFYHCKGGKGVSgeegdggggs 1023
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 507 ---QMMVVTDVGEVFVPL-LDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHS 582
Cdd:PTZ00395 1024 gnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYT 1103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 583 SLPTAeAPGKLKnrddkKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVA--SLGLVPLLTGGTLYK 660
Cdd:PTZ00395 1104 TTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILF 1177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 661 YNVFQIHSDSQRFLTDLRNDI-EKKIGFDAIMRVRTSTG------FRATDFFGGIFMNNTtdVEMAAIDCDKAVTVEFKH 733
Cdd:PTZ00395 1178 VENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHmsvkklFCCNNNFNSIISVDT--IKIPKIRHDQTFAFLLNY 1255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 734 DDKLSEDVGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQplKAIREILVNQT 813
Cdd:PTZ00395 1256 SDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNL 1333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 814 AHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVllSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIH 893
Cdd:PTZ00395 1334 AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIH 1411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 894 ---------TLDVKSAA-LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIF-NVPSfahiNTDMTSLPEV 962
Cdd:PTZ00395 1412 ikgktneidSMDVDDDLfIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVgDIPT----EKNAHELNLT 1487
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568923964 963 GSPHSQQLRMIMNNIQQKKPYS--MKLIVVKQREQREMAFRQFLVEDKGlYGGSSYVDFLCCVHK 1025
Cdd:PTZ00395 1488 DTPNAQKVQRIIKNLSRIHHFNkyVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHK 1551
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
116-1027 |
1.67e-165 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 508.56 E-value: 1.67e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 116 TQLGSQFSSMQINSYGVGATPQSQGPP-----GPQSAGAFQGPPQPAQPSILQPGHQ----VPPPPPTALNGPGASPMSP 186
Cdd:COG5028 2 SQHKKGVYPQAQSQVHTGAASSKKSARphrayANFSAGQMGMPPYTTPPLQQQSRRQidqaATAMHNTGANNPAPSVMSP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 187 pthrqdglpgpaplnaqyqpppppgqtlgpgYPPQQatnygpqmggaqMSYPGGFPGGPAQMAGPAPQLQrkldpdSIPS 266
Cdd:COG5028 82 -------------------------------AFQSQ------------QKFSSPYGGSMADGTAPKPTNP------LVPV 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 267 piqVIENDRATRGGQVYTTnTRGQVPPLvTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPN 346
Cdd:COG5028 113 ---DLFEDQPPPISDLFLP-PPPIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPE 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 347 ETPLYLVNHGEsgPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVA 426
Cdd:COG5028 188 EDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 427 TLDYcrKNKPPSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPkeEHEETSaiRVGFITYNKVLHFFNVKSNLaQP 506
Cdd:COG5028 266 PKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIP--NFDPRT--KIAIICFDSSLHFFKLSPDL-DE 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 507 QMMVVTDVGEVFVPLLDG-FLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPviqagmeALKAA-----ECPGKLFIF 580
Cdd:COG5028 339 QMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVF 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 581 HSSLPTAeAPGKLKNRDDKklvntdkEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYK 660
Cdd:COG5028 412 LSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYF 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 661 YNVFQIHS--DSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLS 738
Cdd:COG5028 484 YPNFSATRpnDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM 563
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 739 EDvGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLA 818
Cdd:COG5028 564 TS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILK 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 819 CYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTL--- 895
Cdd:COG5028 643 AYKKELVKSNTSTQLPLPANLKLLPLLMLALLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpie 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 896 ----DVKSAALPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLR 971
Cdd:COG5028 722 aglpDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVR 801
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 568923964 972 MIMNNIQQKKPYS-MKLIVVKQ--REQREMAFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028 802 NIIGELRSVNDDStLPLVLVRGggDPSLRLWFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
437-696 |
6.07e-114 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 351.58 E-value: 6.07e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEheetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKaaECPGKLFIFHSSLPTAEApGKLKNR 596
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 597 DDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYnvfqihsdsQRFLTD 676
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYY---------PSFNFS 224
|
250 260
....*....|....*....|
gi 568923964 677 LRNDIEKKIGFDAIMRVRTS 696
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
437-681 |
9.06e-107 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 332.29 E-value: 9.06e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPR-----ARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEAPGKLKNR 596
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 597 DDKKLVNTDKEKILFQPQT-AVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFLT 675
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 568923964 676 DLRNDI 681
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
437-677 |
6.69e-95 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 300.70 E-value: 6.69e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 437 PSPPAFIFMIDVSYSNIKNGLVKLICEELKTALKRLPKEEHeetsaIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPR-----ARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 517 VFVPLLDGFLVNYEESQSVIHNLLDQIPEMFAD--SNENETVFAPVIQAGMEALKAAECPGKLFIFHSSLPTAEaPGKLK 594
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 595 NRDDKKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFL 674
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
...
gi 568923964 675 TDL 677
Cdd:cd01468 235 QDL 237
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
439-1025 |
2.79e-48 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 187.97 E-value: 2.79e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 439 PPAFIFMIDVSYSNIKNGLVKLICEELKTALK--RLPKeeheetsaIRVGFITYNKVLHFFNVKSNLAQP---------- 506
Cdd:PTZ00395 952 PPYFVFVVECSYNAIYNNITYTILEGIRYAVQnvKCPQ--------TKIAIITFNSSIYFYHCKGGKGVSgeegdggggs 1023
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 507 ---QMMVVTDVGEVFVPL-LDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGMEALKAAECPGKLFIFHS 582
Cdd:PTZ00395 1024 gnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYT 1103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 583 SLPTAeAPGKLKnrddkKLVNTDKEKILFQPQTAVYESLAKDCVANSCSVTLFLFPSQFVDVA--SLGLVPLLTGGTLYK 660
Cdd:PTZ00395 1104 TTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILF 1177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 661 YNVFQIHSDSQRFLTDLRNDI-EKKIGFDAIMRVRTSTG------FRATDFFGGIFMNNTtdVEMAAIDCDKAVTVEFKH 733
Cdd:PTZ00395 1178 VENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHmsvkklFCCNNNFNSIISVDT--IKIPKIRHDQTFAFLLNY 1255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 734 DDKLSEDVGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVLNQplKAIREILVNQT 813
Cdd:PTZ00395 1256 SDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNL 1333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 814 AHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVllSRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIH 893
Cdd:PTZ00395 1334 AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIH 1411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 894 ---------TLDVKSAA-LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSPPELIQGIF-NVPSfahiNTDMTSLPEV 962
Cdd:PTZ00395 1412 ikgktneidSMDVDDDLfIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVgDIPT----EKNAHELNLT 1487
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568923964 963 GSPHSQQLRMIMNNIQQKKPYS--MKLIVVKQREQREMAFRQFLVEDKGlYGGSSYVDFLCCVHK 1025
Cdd:PTZ00395 1488 DTPNAQKVQRIIKNLSRIHHFNkyVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHK 1551
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
783-883 |
1.88e-34 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 127.23 E-value: 1.88e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 783 DALINFFAKSAFKAVLNQPLKAIREILVNQTAHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVLLSRSEIS 862
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90 100
....*....|....*....|.
gi 568923964 863 PDERAYQRQLVMTMGVADSQL 883
Cdd:pfam04815 83 SDERAYARHLLLSLPVEELLL 103
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
686-770 |
9.27e-30 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 113.02 E-value: 9.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 686 GFDAIMRVRTSTGFRATDFFGGIFMNNTTD-VEMAAIDCDKAVTVEFKHDDKLSEDVGALIQCAVLYTTISGQRRLRIHN 764
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 568923964 765 LALNCS 770
Cdd:pfam08033 81 VALPVT 86
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
312-896 |
4.54e-22 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 102.65 E-value: 4.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFadippNETPLYLVNHGEsgPVRCNR-CKAYMCPFMQFIEGGRRYQCGFCSC 390
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPL-----HEDDALTVNYYE--PVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 391 VNEVPPFYfqhldhigRRLDHYEKPELSLGSYeyvATLDYCRKNKPPSPPAFIFMIDVSYSNIKNGLVKlicEELKTALK 470
Cdd:COG5047 85 RNTLPPQY--------RDISNANLPLELLPQS---STIEYTLSKPVILPPVFFFVVDACCDEEELTALK---DSLIVSLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 471 RLPKEeheetsAIrVGFITYNKVLHFFNV------KSNLAQP----QMMVVTDVGEVFVPLLDG---------------- 524
Cdd:COG5047 151 LLPPE------AL-VGLITYGTSIQVHELnaenhrRSYVFSGnkeyTKENLQELLALSKPTKSGgfeskisgigqfassr 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 525 FLVNYEESQSVIHNLLDQIPEmfaDSNENETVFAPVIQAGMeALKAA---------ECPGKLFIFHSSlPTAEAPGKLKN 595
Cdd:COG5047 224 FLLPTQQCEFKLLNILEQLQP---DPWPVPAGKRPLRCTGS-ALNIAsslleqcfpNAGCHIVLFAGG-PCTVGPGTVVS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 596 RDDKK------LVNTDKEKiLFQPQTAVYESLAKDCVANSCSVTLFLfpSQFVDVASLGLVPLL--TGGTLYKYNVF--Q 665
Cdd:COG5047 299 TELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFA--GCLDQIGIMEMEPLTtsTGGALVLSDSFttS 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 666 IHSDSQRFLTDLRNDIEKKIGFDAIMRVRTSTGFRATDFFG---------------GIFMNNTTDVEMAAID--CDKAVT 728
Cdd:COG5047 376 IFKQSFQRIFNRDSEGYLKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSpkSNYALY 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 729 VEFKHDDKLSEDVG---ALIQCAVLYTTISGQRRLRIHNLALNCSTQLADL-YKSCETDALINFFAK-SAFKAVLNQPLK 803
Cdd:COG5047 456 FEIALGAASGSAQRpaeAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARiAAFKAETEDIID 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 804 AIREI---LVNQTAHmLACYRKhcaspSAASQLILPDSMKVLPVYMNSLLKNcVLLSRSEISPDERAYQRQLVMTMGVAD 880
Cdd:COG5047 536 VFRWIdrnLIRLCQK-FADYRK-----DDPSSFRLDPNFTLYPQFMYHLRRS-PFLSVFNNSPDETAFYRHMLNNADVND 608
|
650
....*....|....*.
gi 568923964 881 SQLFFYPLLLPIHTLD 896
Cdd:COG5047 609 SLIMIQPTLQSYSFEK 624
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
360-396 |
2.27e-15 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 70.55 E-value: 2.27e-15
10 20 30
....*....|....*....|....*....|....*..
gi 568923964 360 PVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVNEVPP 396
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPP 37
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
312-490 |
2.76e-10 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 64.58 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFADIPPNETPLYlvnhgesGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCV 391
Cdd:PLN00162 12 VRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 392 NEVPPFYFQhldhIGrrlDHYEKPELslgsYEYVATLDY---CRKNKPPSPPAFIFMIDVSysniknglvkLICEEL--- 465
Cdd:PLN00162 85 NHFPPHYSS----IS---ETNLPAEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTC----------MIEEELgal 143
|
170 180
....*....|....*....|....*....
gi 568923964 466 KTALKR----LPkeeheETSaiRVGFITY 490
Cdd:PLN00162 144 KSALLQaialLP-----ENA--LVGLITF 165
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
902-974 |
3.18e-10 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 57.32 E-value: 3.18e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568923964 902 LPPAVRCSESRLSEEGIFLLANGLNMFLWFGVGSppELIQGIFNVPSFAHINTDM-TSLPEVG-SPHSQQLRMIM 974
Cdd:pfam00626 4 LPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGS--SLLEKLFAALLAAQLDDDErFPLPEVIrVPQGKEPARFL 76
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
90-267 |
9.57e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.68 E-value: 9.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 90 SVAPSYASGQTL-PQ-SSYPGPGSTSS--------------VTQLGSQFSSMQINSYGVGATPQSQGPPgpqsagafQGP 153
Cdd:PHA03378 587 SSAPSYAQTPWPvPHpSQTPEPPTTQShipetsaprqwpmpLRPIPMRPLRMQPITFNVLVFPTPHQPP--------QVE 658
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 154 PQPAQPSILQPGHQVPPPPPTALN-------------------GPGASPMSPPTHRQ--DGLPGPAPLNAQYQPPPPPGQ 212
Cdd:PHA03378 659 ITPYKPTWTQIGHIPYQPSPTGANtmlpiqwapgtmqppprapTPMRPPAAPPGRAQrpAAATGRARPPAAAPGRARPPA 738
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568923964 213 TLGPGYPPQQATNYG---PQMGGAQMSYPGGFPGGPAQM----AGPAPQLQRKLDPDSIPSP 267
Cdd:PHA03378 739 AAPGRARPPAAAPGRarpPAAAPGRARPPAAAPGAPTPQpppqAPPAPQQRPRGAPTPQPPP 800
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
1-327 |
5.48e-04 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 43.84 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 1 MSQQGYVATP--PYSQSQPGMGISPPHYGHYGDPSHASSPP--GVMKPLGPSAAPSGMLPpgplppgppQFGPNGAHTPG 76
Cdd:pfam09606 162 SSGQPGSGTPnqMGPNGGPGQGQAGGMNGGQQGPMGGQMPPqmGVPGMPGPADAGAQMGQ---------QAQANGGMNPQ 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 77 HPPQrfpgpppvnsvapsyASGQTLPQSSYPGPGSTSSvtQLGSQFSSMQINSYGVG-----ATPQSQGPPGPQSAGAFQ 151
Cdd:pfam09606 233 QMGG---------------APNQVAMQQQQPQQQGQQS--QLGMGINQMQQMPQGVGggagqGGPGQPMGPPGQQPGAMP 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 152 GPPQPAQPSILQPGHQVPPPPPTALNGPGASPMSPPTHRQDGLPGPAPLNAQYQPPPPPGQTLGPGYPPQQATNygPQMG 231
Cdd:pfam09606 296 NVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQ--PGMM 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 232 GAQMSYPGG--------------------FPGGPAQMAGPAPQLQRKLDPDSIPSPI-QVIENDRATRGGQVYT----TN 286
Cdd:pfam09606 374 SSPSPVPGQqvrqvtpnqfmrqspqpsvpSPQGPGSQPPQSHPGGMIPSPALIPSPSpQMSQQPAQQRTIGQDSpggsLN 453
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 568923964 287 TRGQVPplVTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAK 327
Cdd:pfam09606 454 TPGQSA--VNSPLNPQEEQLYREKYRQLTKYIEPLKRMIAK 492
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-293 |
1.33e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 8 ATPPYSQSQPGmgiSPPHYGHYGDP-------SHASSPPGVMKPLGPsAAPSGMLPPGPLPPGPPQFGPNGAHTPGHPPQ 80
Cdd:PHA03247 2699 ADPPPPPPTPE---PAPHALVSATPlppgpaaARQASPALPAAPAPP-AVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 81 RFPGPPPVNSVAPSYASGQTLPqsSYPGPGSTSSVTQLGSQFSSMQINSygvgATPQSQGPPGPQSAGAFQGPPQPAQPS 160
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRE--SLPSPWDPADPPAAVLAPAAALPPA----ASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 161 ILQPGHQVPPPPPTALNGPG----ASPMSPPTHRQDGLPGPAPLNAQYQPPPPPGQTLGPGyPPQQATNYGPQMGGAQMS 236
Cdd:PHA03247 2849 SLPLGGSVAPGGDVRRRPPSrspaAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPP-QPQAPPPPQPQPQPPPPP 2927
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568923964 237 YPGGFPGGPAQmagPAPQLQRKLDPDSIPSPIQVIENDRATRGGQVYTTNTRGQVPP 293
Cdd:PHA03247 2928 QPQPPPPPPPR---PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
28-270 |
1.47e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.75 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 28 HYGDPSHASSPPGVMKPLgPSAAPSGMLPPGPLPPGPPQFGPNGAHTPGHPPQRFPGPPPVNSVAPSYASGQtlpqssyP 107
Cdd:PHA03378 605 TPEPPTTQSHIPETSAPR-QWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ-------P 676
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 108 GPGSTSSVTQLGSQFSSMQINSYGVGATPQSQGPPGPQSAGafQGPPQPAQPSILQPGhqvPPPPPTALNGPGASPMSPP 187
Cdd:PHA03378 677 SPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRP--AAATGRARPPAAAPG---RARPPAAAPGRARPPAAAP 751
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 188 T--HRQDGLPGPAPLNAQYQPPPPpgqtlgpgypPQQAtnygPQMGGAQMSYPGGfpggpaqmaGPAPQLQrkldPDSIP 265
Cdd:PHA03378 752 GraRPPAAAPGRARPPAAAPGAPT----------PQPP----PQAPPAPQQRPRG---------APTPQPP----PQAGP 804
|
....*
gi 568923964 266 SPIQV 270
Cdd:PHA03378 805 TSMQL 809
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
3-271 |
2.28e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.06 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 3 QQGYVATPPYSQSQPGMGI--SPPHYGHYGDPSHASSPPGVMKPLGPSAAPSGMLPPGPLPPG-------PPQFGPNGAH 73
Cdd:pfam03154 164 QQILQTQPPVLQAQSGAASppSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAphtliqqTPTLHPQRLP 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 74 TPGHPPQRFPGPPPVNSVAPsyasgQTLPQSSYPGPGS-TSSVTQLGSQFSSMQINSYGVGATP---QSQGPPGPQSAGa 149
Cdd:pfam03154 244 SPHPPLQPMTQPPPPSQVSP-----QPLPQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPLTPqssQSQVPPGPSPAA- 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 150 fqgpPQPAQPSILQPGHQvppppptalngPGASPMSPPthRQDGLPgPAPLnaQYQPPPPPGQTLGPGYPPQQATNYGPQ 229
Cdd:pfam03154 318 ----PGQSQQRIHTPPSQ-----------SQLQSQQPP--REQPLP-PAPL--SMPHIKPPPTTPIPQLPNPQSHKHPPH 377
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568923964 230 MGG-AQMSYPGGFPGGPAqmAGPAPQLQRKLDPDSIPSPIQVI 271
Cdd:pfam03154 378 LSGpSPFQMNSNLPPPPA--LKPLSSLSTHHPPSAHPPPLQLM 418
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
1-256 |
8.79e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 39.99 E-value: 8.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 1 MSQQGYVATPPYSQSQ--PGMGISPPHYGhygdpshaSSPPGvmkPLGPSAAPSGmlppgplppgppqfGPNGAHTPGHP 78
Cdd:pfam09606 72 MGGGQQGMPDPINALQnlAGQGTRPQMMG--------PMGPG---PGGPMGQQMG--------------GPGTASNLLAS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 79 PQRFPGPPPVNSVAPSYASGQTLPQSSYPGPGSTSSVTQLGSQFSSmQINSYGVGATPQSQGPPGPQsagafQGPPQPAQ 158
Cdd:pfam09606 127 LGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPN-QMGPNGGPGQGQAGGMNGGQ-----QGPMGGQM 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923964 159 PSilQPGHQvppppptalNGPGasPMSPPTHRQDGLPGPAPLNAQYQPPPppgqtlgpgyPPQQATNYGPQMGGAQMSYP 238
Cdd:pfam09606 201 PP--QMGVP---------GMPG--PADAGAQMGQQAQANGGMNPQQMGGA----------PNQVAMQQQQPQQQGQQSQL 257
|
250
....*....|....*...
gi 568923964 239 GGFPGGPAQMAGPAPQLQ 256
Cdd:pfam09606 258 GMGINQMQQMPQGVGGGA 275
|
|
| |
