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Conserved domains on  [gi|568916302|ref|XP_006499232|]
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CCN family member 5 isoform X1 [Mus musculus]

Protein Classification

follistatin-related protein 1( domain architecture ID 10446230)

follistatin-related protein 1 is an extracellular calcium-binding protein belonging to the BM-40/SPARC/osteonectin family and containing Kazal-type serine protease inhibitor/follistatin-like and EF-hand domains, that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 4.84e-09

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.40  E-value: 4.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568916302   26 CPAPC---ACPWTPPQCPPGVplVLDGCGCCRVCARRLGESCDHLH-VCDPsqGLVC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCGK--GLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-159 1.61e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member smart00214:

Pssm-ID: 450195  Cd Length: 59  Bit Score: 38.27  E-value: 1.61e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302   100 CEVNGRRYLDGETFKPNCRVLCRCDDGGF-TCLPLCSEdvrlPSWDCPRPRRIQVPGRCCP 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECP----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 4.84e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.40  E-value: 4.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568916302   26 CPAPC---ACPWTPPQCPPGVplVLDGCGCCRVCARRLGESCDHLH-VCDPsqGLVC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCGK--GLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 26-84 1.32e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 41.68  E-value: 1.32e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302    26 CPAPCA--CPWTPPQCPPGVplVLDGCGCCRVCARRLGESCDhLHVCDPSQGLVCQPGAGP 84
Cdd:smart00121   3 CPPCDParCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGE 60
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 1.61e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 1.61e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302   100 CEVNGRRYLDGETFKPNCRVLCRCDDGGF-TCLPLCSEdvrlPSWDCPRPRRIQVPGRCCP 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECP----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 2.59e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.79  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302  100 CEVNGRRYLDGETFKPNCRVLCRCDDGGFTClplcsEDVRLPSWDCPRPRRIQVPGRCCPE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
 
Name Accession Description Interval E-value
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 4.84e-09

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 50.40  E-value: 4.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568916302   26 CPAPC---ACPWTPPQCPPGVplVLDGCGCCRVCARRLGESCDHLH-VCDPsqGLVC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCGK--GLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 26-84 1.32e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 41.68  E-value: 1.32e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302    26 CPAPCA--CPWTPPQCPPGVplVLDGCGCCRVCARRLGESCDhLHVCDPSQGLVCQPGAGP 84
Cdd:smart00121   3 CPPCDParCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGE 60
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 1.61e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 1.61e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302   100 CEVNGRRYLDGETFKPNCRVLCRCDDGGF-TCLPLCSEdvrlPSWDCPRPRRIQVPGRCCP 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECP----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 2.59e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.79  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568916302  100 CEVNGRRYLDGETFKPNCRVLCRCDDGGFTClplcsEDVRLPSWDCPRPRRIQVPGRCCPE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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