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Conserved domains on  [gi|568915420|ref|XP_006498810|]
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fibrillin-1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.16e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


:

Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.16e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 670-713 3.27e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.27e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   670 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 713
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2070-2113 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1707-1750 2.46e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  1707 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1750
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1551-1591 3.30e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 3.30e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568915420  1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1369-1404 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1369 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1404
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2359-2392 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420  2359 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2392
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 1.38e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568915420   343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 968-1010 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   968 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1010
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1328-1363 9.52e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.52e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 3.28e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1810 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1842
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1238 4.43e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1203 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1238
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-573 2.14e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    532 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 573
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
615-648 7.29e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.29e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 568915420    615 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2129-2167 9.05e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568915420   2129 DMDECKEPDVCRHG-QCINTDGSYRCECPFGYIlEGNECV 2167
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1932-1974 9.41e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568915420   1932 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1974
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2487-2516 1.13e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2487 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2516
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2168-2207 1.71e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   2168 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2207
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1151 2.30e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568915420   1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQLSPN 1151
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2569-2598 2.39e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.39e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420   2569 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2598
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2609-2640 3.48e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.48e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   2609 DENECLSAHVCG-GASCHNTLGSYKCMCPTGFQ 2640
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
574-614 3.95e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.95e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    574 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 614
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1689 4.63e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.63e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1650 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1689
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 862-892 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420   862 GRCEININGATLKSECC-SSLGAAWGSPCTIC 892
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 2444-2484 7.35e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568915420 2444 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2484
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA pfam07645
Calcium-binding EGF domain;
2015-2045 9.93e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2015 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2045
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1768-1798 1.03e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1768 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.23e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1608-1640 1.33e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.33e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1489-1520 1.45e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.45e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1489 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1520
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 1.85e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568915420    246 DVDECQAIPGMCQGGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1448-1488 2.00e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.00e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420   1448 DIDECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1488
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2526-2568 2.10e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568915420   2526 DNNECTSDiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2568
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1975-2010 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1975 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2010
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-798 2.86e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420    767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 798
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568915420   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1072-1106 4.91e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568915420   1072 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1106
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1157-1192 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1157 DINECELSANLCPHGRCVNLIGKYQCACNPGYHPTH 1192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-523 7.28e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.28e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420    492 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 523
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.16e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.16e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 670-713 3.27e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.27e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   670 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 713
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2070-2113 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1707-1750 2.46e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  1707 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1750
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1551-1591 3.30e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 3.30e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568915420  1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1369-1404 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1369 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1404
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2359-2392 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420  2359 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2392
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 1.38e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568915420   343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 968-1010 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   968 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1010
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1328-1363 9.52e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.52e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 3.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1810 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1842
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1810-1845 3.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1810 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRLTS 1845
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1238 4.43e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1203 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1238
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1196-1237 5.53e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.08  E-value: 5.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420 1196 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1237
Cdd:cd01475   183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-573 2.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    532 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 573
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-573 7.25e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 7.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420  532 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrdGKNCE 573
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
615-648 7.29e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.29e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 568915420    615 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2129-2167 9.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568915420   2129 DMDECKEPDVCRHG-QCINTDGSYRCECPFGYIlEGNECV 2167
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1932-1974 9.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568915420   1932 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1974
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2487-2516 1.13e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2487 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2516
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2168-2207 1.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   2168 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2207
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1151 2.30e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568915420   1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQLSPN 1151
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2569-2598 2.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.39e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420   2569 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2598
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 615-644 3.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568915420  615 DINECETPGICMN-GRCVNTDGSYRCECFPG 644
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2129-2161 3.23e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 2129 DMDECKEPDVCR-HGQCINTDGSYRCECPFGYIL 2161
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1932-1963 3.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 3.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1932 DVDECATGNGNLCRNGQCVNTVGSFQCRCNEG 1963
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1365-1405 3.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.44e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1365 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1405
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2609-2640 3.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.48e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   2609 DENECLSAHVCG-GASCHNTLGSYKCMCPTGFQ 2640
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
574-614 3.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.95e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    574 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 614
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1810-1840 4.14e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 4.14e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1810 DIDECQNGP-VCQRNAECINTAGSYRCDCKPG 1840
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1689 4.63e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.63e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1650 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1689
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1324-1359 5.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIGD 1359
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1115-1148 5.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQL 1148
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 862-892 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420   862 GRCEININGATLKSECC-SSLGAAWGSPCTIC 892
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1365-1400 7.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1365 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTGD 1400
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2444-2484 7.35e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568915420 2444 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2484
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1324-1364 8.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIgDGIKCT 1364
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1927-1972 8.89e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 8.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568915420 1927 NNDCIDVDECATGNGNlCRNGqCVNTVGSFQCRCNEGYEVAPDGRT 1972
Cdd:cd01475   181 GKICVVPDLCATLSHV-CQQV-CISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2450-2485 9.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 9.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  2450 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2485
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
2015-2045 9.93e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2015 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2045
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1768-1798 1.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1768 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2569-2598 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568915420 2569 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2598
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1608-1640 1.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.33e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2168-2199 1.34e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.34e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 2168 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 2199
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1489-1520 1.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.45e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1489 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1520
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2609-2640 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 2609 DENECLSAHVCG-GASCHNTLGSYKCMCPTGFQ 2640
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 1.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568915420    246 DVDECQAIPGMCQGGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 574-608 1.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420  574 DMDECSIRNMCLN-GMCINEDGSFKCICKPGFQLAS 608
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1448-1488 2.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.00e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420   1448 DIDECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1488
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1489-1521 2.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1489 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1521
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
2526-2568 2.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568915420   2526 DNNECTSDiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2568
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2482-2518 2.15e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568915420 2482 GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2518
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1975-2010 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1975 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2010
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1650-1681 2.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 1650 DVNECETPGICGP-GTCYNTVGNYTCICPPDYM 1681
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1768-1799 2.72e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.72e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1768 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1799
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-798 2.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420    767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 798
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1448-1482 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1448 DIDECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1482
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568915420   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 767-808 2.95e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420  767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVykpdLKTCE 808
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1608-1641 4.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1641
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1975-2007 4.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420   1975 DINECvLDPGKCAPG-TCQNLDGSYRCICPPGYS 2007
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1072-1106 4.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568915420   1072 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1106
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA pfam07645
Calcium-binding EGF domain;
246-276 5.34e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420   246 DVDECQAIPGMC-QGGNCINTVGSFECKCPAG 276
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1157-1192 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1157 DINECELSANLCPHGRCVNLIGKYQCACNPGYHPTH 1192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1157-1189 5.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420   1157 DINECElSANLCPHG-RCVNLIGKYQCACNPGYH 1189
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2015-2056 5.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420   2015 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslsSTGRRCQ 2056
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1768-1799 6.43e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.43e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568915420 1768 DIDECREIPGVCENGVCINMVGSFRCECPVGF 1799
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-523 7.28e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.28e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420    492 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 523
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2015-2056 7.98e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420 2015 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslssTGRRCQ 2056
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1115-1145 7.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 7.99e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1115 DIDECQRDPLLC-RGGICHNTEGSYRCECPPG 1145
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2526-2561 8.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 8.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 2526 DNNECTSDiNLCGSKGVCQNTPGSFTCECQRGFSLD 2561
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 288-320 9.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 9.44e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420  288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFY 320
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1608-1638 9.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1608 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 1638
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 48-82 3.16e-12

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 62.99  E-value: 3.16e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 670-713 3.27e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 60.37  E-value: 3.27e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   670 GQCVKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALC 713
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2070-2113 8.51e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 8.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  2070 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2113
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1707-1750 2.46e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.46e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420  1707 TCDGELLFNMTKKMCCCSYnIGRAWNKPCEQCPIPSTDEFATLC 1750
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1551-1591 3.30e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 3.30e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568915420  1551 CSNEIGVGVSKASCCC-SLGKAWGTPCELCPSVNTSEYKILC 1591
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1369-1404 6.84e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 53.37  E-value: 6.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1369 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1404
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2359-2392 8.94e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 8.94e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568915420  2359 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2392
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 343-389 1.38e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 568915420   343 GRCSNQLPQSITKMQCCCD-LGRCWSPGvtvaPEMCPIRSTEDFNKLC 389
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP----CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 968-1010 4.55e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 4.55e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568915420   968 ECTLPIAGRHRMDACCC-SVGAAWGtEECEECPLRNSREYEELC 1010
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWG-SPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1328-1363 9.52e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.21  E-value: 9.52e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1328 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1363
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 3.28e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 3.28e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1810 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1842
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1810-1845 3.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1810 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRLTS 1845
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1324-1355 4.24e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 4.24e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1324 DINECEIGAHNCGRHAVCTNTAGSFKCSCSPG 1355
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1203-1238 4.43e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  1203 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1238
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1196-1237 5.53e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.08  E-value: 5.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420 1196 FCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1237
Cdd:cd01475   183 ICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-573 2.14e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 2.14e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    532 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 573
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1365-1396 4.00e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.00e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1365 DLDECSNGTHMCSQHADCKNTMGSYRCLCKDG 1396
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-573 7.25e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 7.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420  532 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrdGKNCE 573
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
615-648 7.29e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.29e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 568915420    615 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2129-2167 9.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 568915420   2129 DMDECKEPDVCRHG-QCINTDGSYRCECPFGYIlEGNECV 2167
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1932-1974 9.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 9.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 568915420   1932 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1974
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
2487-2516 1.13e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 1.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2487 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2516
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2168-2207 1.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   2168 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2207
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1151 2.30e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568915420   1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQLSPN 1151
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2569-2598 2.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.39e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420   2569 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2598
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 615-644 3.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568915420  615 DINECETPGICMN-GRCVNTDGSYRCECFPG 644
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2129-2161 3.23e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 2129 DMDECKEPDVCR-HGQCINTDGSYRCECPFGYIL 2161
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1932-1963 3.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 3.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1932 DVDECATGNGNLCRNGQCVNTVGSFQCRCNEG 1963
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1365-1405 3.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.44e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1365 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1405
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2609-2640 3.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.48e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   2609 DENECLSAHVCG-GASCHNTLGSYKCMCPTGFQ 2640
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
574-614 3.95e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.95e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    574 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 614
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1810-1840 4.14e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 4.14e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1810 DIDECQNGP-VCQRNAECINTAGSYRCDCKPG 1840
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1689 4.63e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.63e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1650 DVNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1689
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1324-1359 5.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIGD 1359
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1115-1148 5.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 5.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1115 DIDECQRDPLLCRGGICHNTEGSYRCECPPGHQL 1148
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 862-892 5.56e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420   862 GRCEININGATLKSECC-SSLGAAWGSPCTIC 892
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1365-1400 7.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1365 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTGD 1400
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2444-2484 7.35e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 7.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568915420 2444 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2484
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1324-1364 8.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568915420   1324 DINECEIGaHNCGRHAVCTNTAGSFKCSCSPGWIgDGIKCT 1364
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1927-1972 8.89e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 8.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568915420 1927 NNDCIDVDECATGNGNlCRNGqCVNTVGSFQCRCNEGYEVAPDGRT 1972
Cdd:cd01475   181 GKICVVPDLCATLSHV-CQQV-CISTPGSYLCACTEGYALLEDNKT 224
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2450-2485 9.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 9.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568915420  2450 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSC 2485
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
2015-2045 9.93e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.93e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2015 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 2045
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1768-1798 1.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1768 DIDECREIPGVC-ENGVCINMVGSFRCECPVG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2569-2598 1.21e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568915420 2569 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2598
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
288-329 1.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1608-1640 1.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.33e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2168-2199 1.34e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.34e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 2168 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 2199
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1932-1974 1.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568915420 1932 DVDECATGNgnLCRN-GQCVNTVGSFQCRCNEGYEvapdGRTCV 1974
Cdd:cd00054     1 DIDECASGN--PCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1489-1520 1.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.45e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1489 DVNECLDPTTCISG-NCVNTPGSYTCDCPPDFE 1520
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2609-2640 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 2609 DENECLSAHVCG-GASCHNTLGSYKCMCPTGFQ 2640
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
246-276 1.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568915420    246 DVDECQAIPGMCQGGNCINTVGSFECKCPAG 276
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 574-608 1.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420  574 DMDECSIRNMCLN-GMCINEDGSFKCICKPGFQLAS 608
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1448-1488 2.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.00e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420   1448 DIDECSLPNICVFG-TCHNLPGLFRCECEIGYEldrSGGNCT 1488
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1489-1521 2.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1489 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1521
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
2526-2568 2.10e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.10e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568915420   2526 DNNECTSDiNLCGSKGVCQNTPGSFTCECQRGFsldQSGASCE 2568
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2482-2518 2.15e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568915420 2482 GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2518
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1975-2010 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1975 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 2010
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1650-1681 2.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420 1650 DVNECETPGICGP-GTCYNTVGNYTCICPPDYM 1681
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1768-1799 2.72e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.72e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568915420   1768 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1799
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
767-798 2.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568915420    767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 798
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1448-1482 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1448 DIDECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1482
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 194-227 2.94e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 37.64  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568915420   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 767-808 2.95e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420  767 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVykpdLKTCE 808
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1608-1641 4.38e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568915420 1608 DIDECQELPGLCQGGKCINTFGSFQCRCPTGYYL 1641
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1975-2007 4.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420   1975 DINECvLDPGKCAPG-TCQNLDGSYRCICPPGYS 2007
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1072-1106 4.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568915420   1072 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1106
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA pfam07645
Calcium-binding EGF domain;
246-276 5.34e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420   246 DVDECQAIPGMC-QGGNCINTVGSFECKCPAG 276
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1157-1192 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 1157 DINECELSANLCPHGRCVNLIGKYQCACNPGYHPTH 1192
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1157-1189 5.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.52e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420   1157 DINECElSANLCPHG-RCVNLIGKYQCACNPGYH 1189
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2015-2056 5.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568915420   2015 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslsSTGRRCQ 2056
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1957-1978 5.95e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 5.95e-03
                           10        20
                   ....*....|....*....|..
gi 568915420  1957 QCRCNEGYEVAPDGRTCVDINE 1978
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1768-1799 6.43e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.43e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568915420 1768 DIDECREIPGVCENGVCINMVGSFRCECPVGF 1799
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
2446-2475 7.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  2446 DLNECNQAPKPC--NFICKNTEGSYQCSCPKG 2475
Cdd:pfam07645    1 DVDECATGTHNCpaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-523 7.28e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.28e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568915420    492 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 523
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2015-2056 7.98e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568915420 2015 DIDECVEEPEICALGTCSNTEGSFKCLCPEGFslssTGRRCQ 2056
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1115-1145 7.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 7.99e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1115 DIDECQRDPLLC-RGGICHNTEGSYRCECPPG 1145
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2526-2561 8.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 8.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568915420 2526 DNNECTSDiNLCGSKGVCQNTPGSFTCECQRGFSLD 2561
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 288-320 9.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 9.44e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568915420  288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFY 320
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1608-1638 9.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568915420  1608 DIDECQELPGLC-QGGKCINTFGSFQCRCPTG 1638
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1936-1973 9.83e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 9.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568915420  1936 CATGNGNLCRNGQCVNTVGSFQCRCNEGYEvaPDGRTC 1973
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYT--GDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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