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Conserved domains on  [gi|568913266|ref|XP_006497903|]
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arrestin domain-containing protein 1 isoform X3 [Mus musculus]

Protein Classification

arrestin family protein( domain architecture ID 10432288)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens thioredoxin-interacting protein and arrestin domain-containing protein

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 3.66e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


:

Pssm-ID: 460676  Cd Length: 135  Bit Score: 85.84  E-value: 3.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568913266  201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 1.21e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 65.00  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266   14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 568913266   93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 252-392 4.28e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247 2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913266  332 LHPPLCISiGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYDPSFSPQRPRRPMSRAVV 392
Cdd:PHA03247 2798 LPSPWDPA-DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 3.66e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 85.84  E-value: 3.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568913266  201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 5.47e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 85.47  E-value: 5.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266   125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSY-------------KAKRWIYDVRTIAEV-EG 190
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYvssdgpvkrslaeKSKEKKADRKTLVKElDG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913266   191 TGVKAWRRAQWQEQILVPALPQSaLPGCSLIHIDYYLQVSM----KAPEATVTLPLFVGNI 247
Cdd:smart01017  81 GPVLPGNKDKFEGQLKVPPLPPT-SRTCRLIKVEYKLKVKLrlsgKHSELRLELPITIGTV 140
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 1.21e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 65.00  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266   14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 568913266   93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 42-98 4.80e-04

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 40.02  E-value: 4.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568913266    42 LPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSP 98
Cdd:smart01017  84 LPGNKDKFEGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTV 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 252-392 4.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247 2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913266  332 LHPPLCISiGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYDPSFSPQRPRRPMSRAVV 392
Cdd:PHA03247 2798 LPSPWDPA-DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 3.66e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 85.84  E-value: 3.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAK----RWIYDVRTIAEVEGTGVKAWRRAQ 200
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKtplgESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568913266  201 WQEQILVPaLPQSALP---GCSLIHIDYYLQVSMKAP----EATVTLPLFVGNI 247
Cdd:pfam02752  81 WEKELQLQ-IPTDLPPsstKCKIIKVEYKLKVTVDLSgsasELRLELPITIGTS 133
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 125-247 5.47e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 85.47  E-value: 5.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266   125 KTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSY-------------KAKRWIYDVRTIAEV-EG 190
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYvssdgpvkrslaeKSKEKKADRKTLVKElDG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913266   191 TGVKAWRRAQWQEQILVPALPQSaLPGCSLIHIDYYLQVSM----KAPEATVTLPLFVGNI 247
Cdd:smart01017  81 GPVLPGNKDKFEGQLKVPPLPPT-SRTCRLIKVEYKLKVKLrlsgKHSELRLELPITIGTV 140
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 14-102 1.21e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 65.00  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266   14 GRVVYGPGEplagtvHLRLGAPLPFRGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTP-RFSKdhKCSLV 92
Cdd:pfam00339  67 GTEVYLPTE------TSLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPwKFNK--SFRRV 138

                          90
                  ....*....|
gi 568913266   93 FYILSPLNLN 102
Cdd:pfam00339 139 FTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 42-98 4.80e-04

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 40.02  E-value: 4.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568913266    42 LPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSP 98
Cdd:smart01017  84 LPGNKDKFEGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGKHSELRLELPITIGTV 140
PHA03247 PHA03247
large tegument protein UL36; Provisional
 252-392 4.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913266  252 TPLSPCPGRESSPGTLslVVPSAPPQEEAEAVASGPHfSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHS 331
Cdd:PHA03247 2721 LPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568913266  332 LHPPLCISiGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYDPSFSPQRPRRPMSRAVV 392
Cdd:PHA03247 2798 LPSPWDPA-DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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