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Conserved domains on  [gi|568911764|ref|XP_006497255|]
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mitochondrial amidoxime-reducing component 1 isoform X1 [Mus musculus]

Protein Classification

MOSC domain-containing protein( domain architecture ID 10507118)

MOSC domain-containing protein similar to vertebrate mitochondrial amidoxime reducing component, which is part of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MOSC_N pfam03476
MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The ...
 58-179 3.65e-50

MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.


:

Pssm-ID: 281474  Cd Length: 118  Bit Score: 160.60  E-value: 3.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764   58 VGTVAQLWIYPIKSCKGLSVSEAECTAMGLRyghlRDRFWLVINEEGNMVTARQEPRLVLISLTC-EDDTLTLSAAYTKD 136
Cdd:pfam03476   1 MARVSSLYVYPIKSCRGESLSRAELTAAGLA----WDRRFMVVDSDGKFVTARREPRLVLIRTTLdEDGGLTLTAPGMPD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568911764  137 LLLPITpPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQ 179
Cdd:pfam03476  77 LSVPLA-DNKFDLRGVLVWGLSFSGRDCGDAAADWFSDFLGKP 118
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 207-248 3.20e-07

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


:

Pssm-ID: 460936  Cd Length: 116  Bit Score: 47.96  E-value: 3.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568911764  207 QVAYSDASPFLVLSEASLEDLNSRL-ERRVKATNFRPNIVISG 248
Cdd:pfam03473   3 KHHGGDDKAVLLYSRESYDAWNAELgRGPLDPGRFRENLVVSG 45
 
Name Accession Description Interval E-value
MOSC_N pfam03476
MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The ...
 58-179 3.65e-50

MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.


Pssm-ID: 281474  Cd Length: 118  Bit Score: 160.60  E-value: 3.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764   58 VGTVAQLWIYPIKSCKGLSVSEAECTAMGLRyghlRDRFWLVINEEGNMVTARQEPRLVLISLTC-EDDTLTLSAAYTKD 136
Cdd:pfam03476   1 MARVSSLYVYPIKSCRGESLSRAELTAAGLA----WDRRFMVVDSDGKFVTARREPRLVLIRTTLdEDGGLTLTAPGMPD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568911764  137 LLLPITpPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQ 179
Cdd:pfam03476  77 LSVPLA-DNKFDLRGVLVWGLSFSGRDCGDAAADWFSDFLGKP 118
YcbX COG3217
N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and ...
 58-254 2.01e-46

N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 442450 [Multi-domain]  Cd Length: 240  Bit Score: 154.96  E-value: 2.01e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764  58 VGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYghlrDRFWLVINEEGNMVTARQEPRLVLISLTCEDDT-LTLSAAYTKD 136
Cdd:COG3217    1 MGRVSRLYRYPVKSLAGEALESATLTAGGLPG----DRRWALVDADGRFLTQRRHPRLALLRARLDEDGgLTLTAPGGES 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764 137 LLLPITPpatnpllqcrvhgleiqgrDCGEDAAQWVSSFLKmQSCRLVHFEPHMRPRssrqmkavfrtkDQVAYSDASPF 216
Cdd:COG3217   77 LTVDLDD-------------------DAGDAAAAWLSEYLG-RPVRLVRLPPESRRG------------PPVGFADGYPV 124

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568911764 217 LVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAE 254
Cdd:COG3217  125 LLISTASLADLNARLGAPVDMRRFRPNLVVDGLEPFAE 162
PLN02724 PLN02724
Molybdenum cofactor sulfurase
 66-254 3.67e-21

Molybdenum cofactor sulfurase


Pssm-ID: 215384 [Multi-domain]  Cd Length: 805  Bit Score: 92.62  E-value: 3.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764  66 IYPIKSCKGLSVSEAECTAMGLRYghlrDRFWLVINEEGNMVTARQEPRLVLIS--LTCEDDTLTLSAAYTKDLL-LPIT 142
Cdd:PLN02724 525 VYPIKSCAGFSVERWPLSETGLLY----DREWMIQSLTGEILTQKKVPEMCLITtfIDLESGKLVVRAPRCDHKLeIPLE 600

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764 143 PPATNPLL-QCRVHGLEIQGRDCGEDAAQWVSSFLKMQsCRLVHFEPHMRPRSSRQMKAVFRTKD---QVAYSDASPFLV 218
Cdd:PLN02724 601 SDSQHEESgEVILCGNRAESMSYGTEINEWFTNALGRR-CTLVRKSSSNTRVCRNRNPSHSPCGDdesRLSFANEGQFLL 679

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568911764 219 LSEASLEDLNSRLE-------RRVKATNFRPNIVISGCGVYAE 254
Cdd:PLN02724 680 ISEASVEDLNRRLAtgqedakIRLDPTRFRPNLVVSGGEAYAE 722
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 207-248 3.20e-07

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 47.96  E-value: 3.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568911764  207 QVAYSDASPFLVLSEASLEDLNSRL-ERRVKATNFRPNIVISG 248
Cdd:pfam03473   3 KHHGGDDKAVLLYSRESYDAWNAELgRGPLDPGRFRENLVVSG 45
 
Name Accession Description Interval E-value
MOSC_N pfam03476
MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The ...
 58-179 3.65e-50

MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.


Pssm-ID: 281474  Cd Length: 118  Bit Score: 160.60  E-value: 3.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764   58 VGTVAQLWIYPIKSCKGLSVSEAECTAMGLRyghlRDRFWLVINEEGNMVTARQEPRLVLISLTC-EDDTLTLSAAYTKD 136
Cdd:pfam03476   1 MARVSSLYVYPIKSCRGESLSRAELTAAGLA----WDRRFMVVDSDGKFVTARREPRLVLIRTTLdEDGGLTLTAPGMPD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568911764  137 LLLPITpPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQ 179
Cdd:pfam03476  77 LSVPLA-DNKFDLRGVLVWGLSFSGRDCGDAAADWFSDFLGKP 118
YcbX COG3217
N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and ...
 58-254 2.01e-46

N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 442450 [Multi-domain]  Cd Length: 240  Bit Score: 154.96  E-value: 2.01e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764  58 VGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYghlrDRFWLVINEEGNMVTARQEPRLVLISLTCEDDT-LTLSAAYTKD 136
Cdd:COG3217    1 MGRVSRLYRYPVKSLAGEALESATLTAGGLPG----DRRWALVDADGRFLTQRRHPRLALLRARLDEDGgLTLTAPGGES 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764 137 LLLPITPpatnpllqcrvhgleiqgrDCGEDAAQWVSSFLKmQSCRLVHFEPHMRPRssrqmkavfrtkDQVAYSDASPF 216
Cdd:COG3217   77 LTVDLDD-------------------DAGDAAAAWLSEYLG-RPVRLVRLPPESRRG------------PPVGFADGYPV 124

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568911764 217 LVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAE 254
Cdd:COG3217  125 LLISTASLADLNARLGAPVDMRRFRPNLVVDGLEPFAE 162
PLN02724 PLN02724
Molybdenum cofactor sulfurase
 66-254 3.67e-21

Molybdenum cofactor sulfurase


Pssm-ID: 215384 [Multi-domain]  Cd Length: 805  Bit Score: 92.62  E-value: 3.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764  66 IYPIKSCKGLSVSEAECTAMGLRYghlrDRFWLVINEEGNMVTARQEPRLVLIS--LTCEDDTLTLSAAYTKDLL-LPIT 142
Cdd:PLN02724 525 VYPIKSCAGFSVERWPLSETGLLY----DREWMIQSLTGEILTQKKVPEMCLITtfIDLESGKLVVRAPRCDHKLeIPLE 600

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911764 143 PPATNPLL-QCRVHGLEIQGRDCGEDAAQWVSSFLKMQsCRLVHFEPHMRPRSSRQMKAVFRTKD---QVAYSDASPFLV 218
Cdd:PLN02724 601 SDSQHEESgEVILCGNRAESMSYGTEINEWFTNALGRR-CTLVRKSSSNTRVCRNRNPSHSPCGDdesRLSFANEGQFLL 679

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568911764 219 LSEASLEDLNSRLE-------RRVKATNFRPNIVISGCGVYAE 254
Cdd:PLN02724 680 ISEASVEDLNRRLAtgqedakIRLDPTRFRPNLVVSGGEAYAE 722
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 207-248 3.20e-07

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 47.96  E-value: 3.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568911764  207 QVAYSDASPFLVLSEASLEDLNSRL-ERRVKATNFRPNIVISG 248
Cdd:pfam03473   3 KHHGGDDKAVLLYSRESYDAWNAELgRGPLDPGRFRENLVVSG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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