|
Name |
Accession |
Description |
Interval |
E-value |
| AspS |
COG0173 |
Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Aspartyl-tRNA ... |
1-505 |
0e+00 |
|
Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Aspartyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439943 [Multi-domain] Cd Length: 589 Bit Score: 689.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 1 MPTGEIEIKVKTAELLNACKKLPFEIKDFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNlHGFVDIETP 80
Cdd:COG0173 89 LPTGEIEVLASELEILNKAKTPPFQIDDDTDVSEELRLKYRYLDLRRPEMQKNLILRHKVTKAIRNYLDE-NGFLEIETP 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 81 TLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTG 159
Cdd:COG0173 168 ILTKSTPEGARDYLVPSRvHPGKFYALPQSPQLFKQLLMVSGFDRYFQIARCFRDEDLRADRQPEFTQLDIEMSFVDQED 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 160 IQRLVEGLLQYSWP--GDKDpLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDVSDVFRNTELRFLQDAlAKPQGTVKAI 237
Cdd:COG0173 248 VFELMEGLIRHLFKevLGVE-LPTPFPRMTYAEAMERYGSDKPDLRFGLELVDVTDIFKDSGFKVFAGA-AENGGRVKAI 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 238 CVHDGAKYLRKEdIEFIRKFAVHHFSQEVLPIFLNAKKnWSSPFAKFIMEEERLELARSMEIQEEDIVLLTAGEHEKACS 317
Cdd:COG0173 326 NVPGGASLSRKQ-IDELTEFAKQYGAKGLAYIKVNEDG-LKSPIAKFLSEEELAAILERLGAKPGDLIFFVADKPKVVNK 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 318 LLGKLRLECADLLEmrgavLRDPAVFSFLWVVDFPLFlakEESPTE--LESAHHPFTAPNSSDIHLLYTEPEKVRGQHYD 395
Cdd:COG0173 404 ALGALRLKLGKELG-----LIDEDEFAFLWVVDFPLF---EYDEEEgrWVAMHHPFTMPKDEDLDLLETDPGKVRAKAYD 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 396 LVLNGNEIGGGSVRIHDAQLQRYILETL--LKEDVKL-LSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFP 472
Cdd:COG0173 476 LVLNGYELGGGSIRIHDPELQEKVFELLgiSEEEAEEkFGFLLEAFKYGAPPHGGIAFGLDRLVMLLAGEDSIRDVIAFP 555
|
490 500 510
....*....|....*....|....*....|...
gi 568910677 473 KSYRGQDLMSNAPDSVSPEELKPYHIHVLWPAD 505
Cdd:COG0173 556 KTQSAQDLMTGAPSEVDEKQLKELHIRLRPPEK 588
|
|
| aspS |
PRK00476 |
aspartyl-tRNA synthetase; Validated |
1-504 |
0e+00 |
|
aspartyl-tRNA synthetase; Validated
Pssm-ID: 234775 [Multi-domain] Cd Length: 588 Bit Score: 669.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 1 MPTGEIEIKVKTAELLNACKKLPFEIKDFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLcNLHGFVDIETP 80
Cdd:PRK00476 88 LPTGEIEVLASELEVLNKSKTLPFPIDDEEDVSEELRLKYRYLDLRRPEMQKNLKLRSKVTSAIRNFL-DDNGFLEIETP 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 81 TLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTG 159
Cdd:PRK00476 167 ILTKSTPEGARDYLVPSRvHPGKFYALPQSPQLFKQLLMVAGFDRYYQIARCFRDEDLRADRQPEFTQIDIEMSFVTQED 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 160 IQRLVEGLLQYSWpgdKD----PLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDVSDVFRNTELRFLQDALAKpQGTVK 235
Cdd:PRK00476 247 VMALMEGLIRHVF---KEvlgvDLPTPFPRMTYAEAMRRYGSDKPDLRFGLELVDVTDLFKDSGFKVFAGAAND-GGRVK 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 236 AICVHDGAKYLRKEDIEFIRKFAVHHFSQEVLPIFLNAKKnWSSPFAKFIMEEERLELARSMEIQEEDIVLLTAGEHEKA 315
Cdd:PRK00476 323 AIRVPGGAAQLSRKQIDELTEFAKIYGAKGLAYIKVNEDG-LKGPIAKFLSEEELAALLERTGAKDGDLIFFGADKAKVV 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 316 CSLLGKLRLECADLLEmrgavLRDPAVFSFLWVVDFPLFLAKEESPTeLESAHHPFTAPNSSDIH-LLYTEPEKVRGQHY 394
Cdd:PRK00476 402 NDALGALRLKLGKELG-----LIDEDKFAFLWVVDFPMFEYDEEEGR-WVAAHHPFTMPKDEDLDeLETTDPGKARAYAY 475
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 395 DLVLNGNEIGGGSVRIHDAQLQRYILETL--LKEDVKL-LSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAF 471
Cdd:PRK00476 476 DLVLNGYELGGGSIRIHRPEIQEKVFEILgiSEEEAEEkFGFLLDALKYGAPPHGGIAFGLDRLVMLLAGADSIRDVIAF 555
|
490 500 510
....*....|....*....|....*....|...
gi 568910677 472 PKSYRGQDLMSNAPDSVSPEELKPYHIHVLWPA 504
Cdd:PRK00476 556 PKTQSAQDLLTGAPSPVDEKQLRELGIRLRKKE 588
|
|
| aspS_bact |
TIGR00459 |
aspartyl-tRNA synthetase, bacterial type; Asparate--tRNA ligases in this family may be ... |
1-498 |
0e+00 |
|
aspartyl-tRNA synthetase, bacterial type; Asparate--tRNA ligases in this family may be discriminating (6.1.1.12) or nondiscriminating (6.1.1.23). In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This model, aspS_bact, represents aspartyl-tRNA synthetases from the Bacteria and from mitochondria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn). This model generates very low scores for the archaeal type of aspS and for asnS; scores between the trusted and noise cutoffs represent fragmentary sequences. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 211576 [Multi-domain] Cd Length: 583 Bit Score: 529.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 1 MPTGEIEIKVKTAELLNACKKLPFEIKDfVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLcNLHGFVDIETP 80
Cdd:TIGR00459 86 LDTGEIEILAESITLLNKSKTPPLIIEK-TDAEEEVRLKYRYLDLRRPEMQQRLKLRHKVTKAVRNFL-DQQGFLEIETP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 81 TLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTG 159
Cdd:TIGR00459 164 MLTKSTPEGARDYLVPSRvHKGEFYALPQSPQLFKQLLMVSGVDRYYQIARCFRDEDLRADRQPEFTQIDMEMSFMTQED 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 160 IQRLVEGLLQYSWPGDKD-PLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDVSDVFRNTELRFLQdALAKPQGTVKAIC 238
Cdd:TIGR00459 244 VMELIEKLVSHVFLEVKGiDLKKPFPVMTYAEAMERYGSDKPDLRFPLELIDVTDLFKDSEFKVFS-NLINDGGRVKAIR 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 239 VHDGAKYLRKEDIEFIRKFAVHHFSQEVLPIFLNAKKNwSSPFAKFIMEEERLELARSMEIQEEDIVLLTAGEHEKACSL 318
Cdd:TIGR00459 323 VPGGWAELSRKSIKELRKFAKEYGAKGLAYLKVNEDGI-NSPIKKFLDEKKGKILLERTDAQNGDILLFGAGSKKIVLDA 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 319 LGKLRLECADLLEmrgavLRDPAVFSFLWVVDFPLFLAKEESptELESAHHPFTAPNSSDIHLLYTEPEKVRGQHYDLVL 398
Cdd:TIGR00459 402 LGALRLKLGKDLG-----LVDPDLFSFLWVVDFPMFEKDKEG--RLCAAHHPFTMPKDEDLENLEAAPEEALAEAYDLVL 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 399 NGNEIGGGSVRIHDAQLQRYILETL---LKEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPKSY 475
Cdd:TIGR00459 475 NGVELGGGSIRIHDPEVQKKVFEILgidPEEAREKFGFLLEAFKYGTPPHAGFALGLDRLMMLLTGTDNIRDVIAFPKTT 554
|
490 500
....*....|....*....|...
gi 568910677 476 RGQDLMSNAPDSVSPEELKPYHI 498
Cdd:TIGR00459 555 AAACLMTEAPSFIDEKQLEELSI 577
|
|
| PLN02903 |
PLN02903 |
aminoacyl-tRNA ligase |
1-498 |
1.12e-160 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215490 [Multi-domain] Cd Length: 652 Bit Score: 471.58 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 1 MPTGEIEIKVKTAELLNAC-KKLPFEI------KDFVKktEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHG 73
Cdd:PLN02903 145 MKTGSVEVVAESVDILNVVtKSLPFLVttadeqKDSIK--EEVRLRYRVLDLRRPQMNANLRLRHRVVKLIRRYLEDVHG 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 74 FVDIETPTLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEM 152
Cdd:PLN02903 223 FVEIETPILSRSTPEGARDYLVPSRvQPGTFYALPQSPQLFKQMLMVSGFDRYYQIARCFRDEDLRADRQPEFTQLDMEL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 153 SFVEQTGIQRLVEGLLQYSWPGDKD-PLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDVSDVFRNTELRFLQDALAKpQ 231
Cdd:PLN02903 303 AFTPLEDMLKLNEDLIRQVFKEIKGvQLPNPFPRLTYAEAMSKYGSDKPDLRYGLELVDVSDVFAESSFKVFAGALES-G 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 232 GTVKAICVHDGAKY-----LRKEDI--EFIRKFAvhhfsqEVLPiFLNAKKNWSSPFAKFIME----EERLELARSMEIQ 300
Cdd:PLN02903 382 GVVKAICVPDGKKIsnntaLKKGDIynEAIKSGA------KGLA-FLKVLDDGELEGIKALVEslspEQAEQLLAACGAG 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 301 EEDIVLLTAGEHEKACSLLGKLRLECADLLEMrgavlRDPAVFSFLWVVDFPLFlakEESPTE--LESAHHPFTAPNSSD 378
Cdd:PLN02903 455 PGDLILFAAGPTSSVNKTLDRLRQFIAKTLDL-----IDPSRHSILWVTDFPMF---EWNEDEqrLEALHHPFTAPNPED 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 379 IHLLytepEKVRGQHYDLVLNGNEIGGGSVRIHDAQLQRYILET--LLKEDVK-LLSHLLQALDYGAPPHGGIALGLDRL 455
Cdd:PLN02903 527 MGDL----SSARALAYDMVYNGVEIGGGSLRIYRRDVQQKVLEAigLSPEEAEsKFGYLLEALDMGAPPHGGIAYGLDRL 602
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 568910677 456 VCLVTGAPSIRDVIAFPKSYRGQDLMSNAPDSVSPEELKPYHI 498
Cdd:PLN02903 603 VMLLAGAKSIRDVIAFPKTTTAQCALTRAPSEVDDKQLQDLSI 645
|
|
| AspRS_core |
cd00777 |
Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its ... |
54-474 |
5.04e-143 |
|
Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the appropriate tRNA. The catalytic core domain is primarily responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. AspRS in this family differ from those found in the AsxRS family by a GAD insert in the core domain.
Pssm-ID: 238400 [Multi-domain] Cd Length: 280 Bit Score: 412.74 E-value: 5.04e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 54 LRLRSQMVMKMREYLCNlHGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCY 132
Cdd:cd00777 1 LRLRSRVIKAIRNFLDE-QGFVEIETPILTKSTPEGARDFLVPSRlHPGKFYALPQSPQLFKQLLMVSGFDRYFQIARCF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 133 RDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQYSWPGDKD-PLVTPFPSMTFAEALATYGtdkpdtrfgmkivdv 211
Cdd:cd00777 80 RDEDLRADRQPEFTQIDIEMSFVDQEDIMSLIEGLLKYVFKEVLGvELTTPFPRMTYAEAMERYG--------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 212 sdvfrntelrflqdalakpqgtvkaicvhdgakylrkediefirkfavhhfsqevlpiflnakknwsspfakfimeeerl 291
Cdd:cd00777 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 292 elarsmeiqeedivlltagehekacsllgklrlecadllemrgavlrdpavFSFLWVVDFPLFLaKEESPTELESAHHPF 371
Cdd:cd00777 145 ---------------------------------------------------FKFLWIVDFPLFE-WDEEEGRLVSAHHPF 172
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 372 TAPNSSDIHLLYTEPEKVRGQHYDLVLNGNEIGGGSVRIHDAQLQRYILETLLK---EDVKLLSHLLQALDYGAPPHGGI 448
Cdd:cd00777 173 TAPKEEDLDLLEKDPEDARAQAYDLVLNGVELGGGSIRIHDPDIQEKVFEILGLseeEAEEKFGFLLEAFKYGAPPHGGI 252
|
410 420
....*....|....*....|....*.
gi 568910677 449 ALGLDRLVCLVTGAPSIRDVIAFPKS 474
Cdd:cd00777 253 ALGLDRLVMLLTGSESIRDVIAFPKT 278
|
|
| PRK12820 |
PRK12820 |
bifunctional aspartyl-tRNA synthetase/aspartyl/glutamyl-tRNA amidotransferase subunit C; ... |
3-494 |
1.32e-136 |
|
bifunctional aspartyl-tRNA synthetase/aspartyl/glutamyl-tRNA amidotransferase subunit C; Provisional
Pssm-ID: 105955 [Multi-domain] Cd Length: 706 Bit Score: 411.69 E-value: 1.32e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 3 TGEIEIKVKTAELLNACKKLPFEIKDFVKK-----------TEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLcNL 71
Cdd:PRK12820 94 TGDIEVFVRELSILAASEALPFAISDKAMTagagsagadavNEDLRLQYRYLDIRRPAMQDHLAKRHRIIKCARDFL-DS 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 72 HGFVDIETPTLFKRTPGGAKEFLVPSR-EPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDI 150
Cdd:PRK12820 173 RGFLEIETPILTKSTPEGARDYLVPSRiHPKEFYALPQSPQLFKQLLMIAGFERYFQLARCFRDEDLRPNRQPEFTQLDI 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 151 EMSFVEQTGIQRLVEGLLQYSWPGDKDPLVTPFPSMTFAEALATYGTDKPDTRFGMKIVDVSDVFRNTELRFLQDALAKp 230
Cdd:PRK12820 253 EASFIDEEFIFELIEELTARMFAIGGIALPRPFPRMPYAEAMDTTGSDRPDLRFDLKFADATDIFENTRYGIFKQILQR- 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 231 QGTVKAICVHDGAKYLRKEDIEfirkfavHHFSQEVLPIFLNAKKNW--------SSPFAKFIMEEERLELARSMEIQEE 302
Cdd:PRK12820 332 GGRIKGINIKGQSEKLSKNVLQ-------NEYAKEIAPSFGAKGMTWmraeagglDSNIVQFFSADEKEALKRRFHAEDG 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 303 DIVLLTA-GEHEKACSLLGKLRLECADLLEmrgavLRDPAVFSFLWVVDFPLFLAKEESptELESAHHPFTAPNSSDIHL 381
Cdd:PRK12820 405 DVIIMIAdASCAIVLSALGQLRLHLADRLG-----LIPEGVFHPLWITDFPLFEATDDG--GVTSSHHPFTAPDREDFDP 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 382 LYTEP-EKVRGQHYDLVLNGNEIGGGSVRIHDAQLQRYILET--LLKEDVK-LLSHLLQALDYGAPPHGGIALGLDRLVC 457
Cdd:PRK12820 478 GDIEElLDLRSRAYDLVVNGEELGGGSIRINDKDIQLRIFAAlgLSEEDIEdKFGFFLRAFDFAAPPHGGIALGLDRVVS 557
|
490 500 510
....*....|....*....|....*....|....*..
gi 568910677 458 LVTGAPSIRDVIAFPKSYRGQDLMSNAPDSVSPEELK 494
Cdd:PRK12820 558 MILQTPSIREVIAFPKNRSAACPLTGAPSEVAQEQLA 594
|
|
| tRNA-synt_2 |
pfam00152 |
tRNA synthetases class II (D, K and N); |
34-473 |
6.27e-117 |
|
tRNA synthetases class II (D, K and N);
Pssm-ID: 425487 [Multi-domain] Cd Length: 318 Bit Score: 347.63 E-value: 6.27e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 34 EALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNlHGFVDIETPTLFK-RTPGGAKEFLVPSREPGKFYSLPQSPQQ 112
Cdd:pfam00152 2 EETRLKYRYLDLRRPKMQANLKLRSKIIKAIRNFLDE-NGFLEVETPILTKsATPEGARDFLVPSRALGKFYALPQSPQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 113 FKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQYSW-----------PGDKDPLVT 181
Cdd:pfam00152 81 YKQLLMVAGFDRVFQIARCFRDEDLRTDRQPEFTQLDLEMSFVDYEDVMDLTEELIKEIFkevegiakeleGGTLLDLKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 182 PFPSMTFAEAL----------ATYGTDKPDTRFGMKIVdvsdvfrntelrflqdalakpqgtvkaicvhdgakylrkedi 251
Cdd:pfam00152 161 PFPRITYAEAIeklngkdveeLGYGSDKPDLRFLLELV------------------------------------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 252 efirkfavhhfsqevlpiflnakknwsspfakfimeeerlelarsmeiqeedivlltagehekacsllgklrlecadlle 331
Cdd:pfam00152 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 332 mrgavlRDPAVFSFLWVVDFPlflakeespteleSAHHPFTAPNSSDIhllytepeKVRGQHYDLVLNGNEIGGGSVRIH 411
Cdd:pfam00152 199 ------IDKNKFNPLWVTDFP-------------AEHHPFTMPKDEDD--------PALAEAFDLVLNGVEIGGGSIRIH 251
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910677 412 DAQLQRYILETLL---KEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPK 473
Cdd:pfam00152 252 DPELQEERFEEQGldpEEAEEKFGFYLDALKYGAPPHGGLGIGLDRLVMLLTGLESIREVIAFPK 316
|
|
| Asp_Lys_Asn_RS_core |
cd00669 |
Asp_Lys_Asn_tRNA synthetase class II core domain. This domain is the core catalytic domain of ... |
54-476 |
8.02e-61 |
|
Asp_Lys_Asn_tRNA synthetase class II core domain. This domain is the core catalytic domain of class II aminoacyl-tRNA synthetases of the subgroup containing aspartyl, lysyl, and asparaginyl tRNA synthetases. It is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. Nearly all class II tRNA synthetases are dimers and enzymes in this subgroup are homodimers. These enzymes attach a specific amino acid to the 3' OH group of ribose of the appropriate tRNA.
Pssm-ID: 238358 [Multi-domain] Cd Length: 269 Bit Score: 201.17 E-value: 8.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 54 LRLRSQMVMKMREYLCNlHGFVDIETPTLFKRTPG-GAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCY 132
Cdd:cd00669 1 FKVRSKIIKAIRDFMDD-RGFLEVETPMLQKITGGaGARPFLVKYNALGLDYYLRISPQLFKKRLMVGGLDRVFEINRNF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 133 RDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQYSWpgdkdplvtpfpsmtfAEALATYgtdkpdtrfgmkivdvs 212
Cdd:cd00669 80 RNEDLRARHQPEFTMMDLEMAFADYEDVIELTERLVRHLA----------------REVLGVT----------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 213 dvfrntelrflqdalakpqgtvkaicvhdgAKYLRKEDIEFIRKFavhhfsqevlpiflnakknwsspfakfimeeERLE 292
Cdd:cd00669 127 ------------------------------AVTYGFELEDFGLPF-------------------------------PRLT 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 293 LARSMEIqeedivlltagehekacsllgklrlecadllemrgavLRDPavfsfLWVVDFPLFlakeesptelesAHHPFT 372
Cdd:cd00669 146 YREALER-------------------------------------YGQP-----LFLTDYPAE------------MHSPLA 171
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 373 APNSSDihllytePEKVRGqhYDLVLNGNEIGGGSVRIHDAQLQ-RYILETLLKEDVKLLS--HLLQALDYGAPPHGGIA 449
Cdd:cd00669 172 SPHDVN-------PEIADA--FDLFINGVEVGNGSSRLHDPDIQaEVFQEQGINKEAGMEYfeFYLKALEYGLPPHGGLG 242
|
410 420
....*....|....*....|....*..
gi 568910677 450 LGLDRLVCLVTGAPSIRDVIAFPKSYR 476
Cdd:cd00669 243 IGIDRLIMLMTNSPTIREVIAFPKMRR 269
|
|
| aspC |
PRK05159 |
aspartyl-tRNA synthetase; Provisional |
2-472 |
1.02e-36 |
|
aspartyl-tRNA synthetase; Provisional
Pssm-ID: 235354 [Multi-domain] Cd Length: 437 Bit Score: 141.10 E-value: 1.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 2 PTGeIEIKVKTAELLN-ACKKLPFEIKDFVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNlHGFVDIETP 80
Cdd:PRK05159 84 PGG-VEVIPEEIEVLNkAEEPLPLDISGKVLAELDTRLDNRFLDLRRPRVRAIFKIRSEVLRAFREFLYE-NGFTEIFTP 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 81 TLFKR-TPGGAKEFLVPSREPGKFysLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVE-Q 157
Cdd:PRK05159 162 KIVASgTEGGAELFPIDYFEKEAY--LAQSPQLYKQMMVGAGFERVFEIGPVFRAEEHNTSRHlNEYTSIDVEMGFIDdH 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 158 TGIQRLVEGLLQYswpgdkdplvtpfpsmTFAEALATYGtdkpdtrfgmkivdvsdvfrnTELRFLQDALAKPQGTVKAI 237
Cdd:PRK05159 240 EDVMDLLENLLRY----------------MYEDVAENCE---------------------KELELLGIELPVPETPIPRI 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 238 cvhdgakylrkediefirkfavhHFsqevlpiflnakknwsspfakfimeEERLELARSMEIQ---EEDivLLTAGEHek 314
Cdd:PRK05159 283 -----------------------TY-------------------------DEAIEILKSKGNEiswGDD--LDTEGER-- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 315 acsLLGKlrlecaDLLEMRGAvlrdpavfSFLWVVDFPlflakeespteleSAHHPF-TAPNSSDihllytePEKVRGqh 393
Cdd:PRK05159 311 ---LLGE------YVKEEYGS--------DFYFITDYP-------------SEKRPFyTMPDEDD-------PEISKS-- 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 394 YDLVLNGNEIGGGSVRIHDAQLqryiLETLLKE---DVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIA 470
Cdd:PRK05159 352 FDLLFRGLEITSGGQRIHRYDM----LVESIKEkglNPESFEFYLEAFKYGMPPHGGFGLGLERLTMKLLGLENIREAVL 427
|
..
gi 568910677 471 FP 472
Cdd:PRK05159 428 FP 429
|
|
| AsnS |
COG0017 |
Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ... |
4-472 |
1.18e-29 |
|
Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Aspartyl/asparaginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439788 [Multi-domain] Cd Length: 430 Bit Score: 120.93 E-value: 1.18e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 4 GEIEIKVKTAELLNACKK-LPFEIK----DFvkktealRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLcNLHGFVDIE 78
Cdd:COG0017 82 QGVELQAEEIEVLGEADEpYPLQPKrhslEF-------LLDNRHLRLRTNRFGAIFRIRSELARAIREFF-QERGFVEVH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 79 TPTLfkrTP----GGAKEFLVpsrepgKFY----SLPQSPQQFKQLlMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQID 149
Cdd:COG0017 154 TPII---TAsateGGGELFPV------DYFgkeaYLTQSGQLYKEA-LAMALEKVYTFGPTFRAEKSNTRRHlAEFWMIE 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 150 IEMSFVEQTGIQRLVEGLLQYSwpgdkdplvtpfpsmtfaealatygtdkpdtrfgmkivdVSDVFRNtelrflqdalak 229
Cdd:COG0017 224 PEMAFADLEDVMDLAEEMLKYI---------------------------------------IKYVLEN------------ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 230 pqgtvkaicvhdgakylRKEDIEFIRKFAvhhfsqEVLPIFLNakknwsSPFAKFIMEE--ERLElARSMEIQ-EEDIvl 306
Cdd:COG0017 253 -----------------CPEELEFLGRDV------ERLEKVPE------SPFPRITYTEaiEILK-KSGEKVEwGDDL-- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 307 ltAGEHEKAcslLGKlrlecadllemrgaVLRDPAVFsflwVVDFplflakeesPTELEsahhPF-TAPNSSDihllyte 385
Cdd:COG0017 301 --GTEHERY---LGE--------------EFFKKPVF----VTDY---------PKEIK----AFyMKPNPDD------- 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 386 PEKVRGqhYDLVLNG-NEIGGGSVRIHDAQLqryiLETLLKE---DVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTG 461
Cdd:COG0017 338 PKTVAA--FDLLAPGiGEIIGGSQREHRYDV----LVERIKEkglDPEDYEWYLDLRRYGSVPHAGFGLGLERLVMWLTG 411
|
490
....*....|.
gi 568910677 462 APSIRDVIAFP 472
Cdd:COG0017 412 LENIREVIPFP 422
|
|
| AsxRS_core |
cd00776 |
Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA ... |
37-473 |
1.54e-29 |
|
Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as a subgroup of AspRS. AsnRS and AspRS are homodimers, which attach either asparagine or aspartate to the 3'OH group of ribose of the appropriate tRNA. While archaea lack asnRS, they possess a non-discriminating aspRS, which can mischarge Asp-tRNA with Asn. Subsequently, a tRNA-dependent aspartate amidotransferase converts the bound aspartate to asparagine. The catalytic core domain is primarily responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate.
Pssm-ID: 238399 [Multi-domain] Cd Length: 322 Bit Score: 118.44 E-value: 1.54e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 37 RLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLcNLHGFVDIETPTLFKR-TPGGAKEFlvpsrePGKFYS----LPQSPQ 111
Cdd:cd00776 7 LLDNRHLDLRTPKVQAIFRIRSEVLRAFREFL-RENGFTEVHTPKITSTdTEGGAELF------KVSYFGkpayLAQSPQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 112 QFKQlLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVEQ-TGIQRLVEGLLQYswpgdkdplvtpfpsmTFA 189
Cdd:cd00776 80 LYKE-MLIAALERVYEIGPVFRAEKSNTRRHlSEFWMLEAEMAFIEDyNEVMDLIEELIKY----------------IFK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 190 EALATYGTDkpdtrfgMKIVDVsdvfrnteLRFLQDALAKPqgtVKAICVHDGAKYLRKEDIEFirkfavhhfsqevlpi 269
Cdd:cd00776 143 RVLERCAKE-------LELVNQ--------LNRELLKPLEP---FPRITYDEAIELLREKGVEE---------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 270 flnaKKNWsspfakfimeeerlelarsmeiqEEDIvlltAGEHEKacsLLGKLrlecadllemrgavLRDPAVFsflwVV 349
Cdd:cd00776 189 ----EVKW-----------------------GEDL----STEHER---LLGEI--------------VKGDPVF----VT 216
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 350 DFPlflakeespteleSAHHPFTAPNSSDihllytEPEKVRGqhYDLVLNGN-EIGGGSVRIHDAQ-LQRYILEtlLKED 427
Cdd:cd00776 217 DYP-------------KEIKPFYMKPDDD------NPETVES--FDLLMPGVgEIVGGSQRIHDYDeLEERIKE--HGLD 273
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 568910677 428 VKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPK 473
Cdd:cd00776 274 PESFEWYLDLRKYGMPPHGGFGLGLERLVMWLLGLDNIREAILFPR 319
|
|
| EcAspRS_like_N |
cd04317 |
EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli ... |
1-50 |
1.19e-21 |
|
EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) Helicobacter pylori AspRS. These homodimeric enzymes are class2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. aaRSs catalyze the specific attachment of amino acids (AAs) to their cognate tRNAs during protein biosynthesis. This 2-step reaction involves i) the activation of the AA by ATP in the presence of magnesium ions, followed by ii) the transfer of the activated AA to the terminal ribose of tRNA. In the case of the class2b aaRSs, the activated AA is attached to the 3'OH of the terminal ribose. Eukaryotes contain 2 sets of aaRSs, both of which are encoded by the nuclear genome. One set concerns with cytoplasmic synthesis, whereas the other exclusively with mitochondrial protein synthesis. Human mtAspRS participates in mitochondrial biosynthesis; this enzyme been shown to charge E.coli native tRNAsp in addition to in vitro transcribed human mitochondrial tRNAsp. T. thermophilus is rare among bacteria in having both a D_AspRS and a ND_AspRS. H.pylori ND-AspRS can charge both tRNAASp and tRNAAsn, it is fractionally more efficient at aminoacylating tRNAAsp over tRNAAsn. The H.pylori genome does not contain AsnRS.
Pssm-ID: 239812 [Multi-domain] Cd Length: 135 Bit Score: 90.66 E-value: 1.19e-21
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 568910677 1 MPTGEIEIKVKTAELLNACKKLPFEIKDFVKKTEALRLQYRYLDLRSFQM 50
Cdd:cd04317 86 LPTGEIEVVASELEVLNKAKTLPFEIDDDVNVSEELRLKYRYLDLRRPKM 135
|
|
| PLN02850 |
PLN02850 |
aspartate-tRNA ligase |
3-473 |
2.13e-21 |
|
aspartate-tRNA ligase
Pssm-ID: 215456 [Multi-domain] Cd Length: 530 Bit Score: 97.47 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 3 TGEIEIKVKTAELLN-ACKKLPFEIKD-----------------FVKKTEALRLQYRYLDLRSFQMQYNLRLRSQMVMKM 64
Cdd:PLN02850 156 TQQVEIQVRKIYCVSkALATLPFNVEDaarseseiekalqtgeqLVRVGQDTRLNNRVLDLRTPANQAIFRIQSQVCNLF 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 65 REYLCNlHGFVDIETPTLFK-RTPGGAKEFLVPSRepGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ- 142
Cdd:PLN02850 236 REFLLS-KGFVEIHTPKLIAgASEGGSAVFRLDYK--GQPACLAQSPQLHKQMAICGDFRRVFEIGPVFRAEDSFTHRHl 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 143 PEFTQIDIEMSFVEQ-TGIQRLVEGLlqyswpgdkdplvtpFPSMtFaealatygtDKPDTRFGMKIVDVsdvfrNTELR 221
Cdd:PLN02850 313 CEFTGLDLEMEIKEHySEVLDVVDEL---------------FVAI-F---------DGLNERCKKELEAI-----REQYP 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 222 FlqdalakpqgtvkaicvhdgakylrkEDIEFIRKFAVHHFsqevlpiflnakknwsspfakfimeEERLELARSMEIQE 301
Cdd:PLN02850 363 F--------------------------EPLKYLPKTLRLTF-------------------------AEGIQMLKEAGVEV 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 302 EDIVLLTaGEHEKAcslLGKLrlecadLLEMRGAvlrdpavfSFLWVVDFPLflakeesptelesAHHPF-TAPNSSDIh 380
Cdd:PLN02850 392 DPLGDLN-TESERK---LGQL------VKEKYGT--------DFYILHRYPL-------------AVRPFyTMPCPDDP- 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 381 lLYTepekvrgQHYDLVLNGNEIGGGSVRIHDAQLqryiLETLLKE---DVKLLSHLLQALDYGAPPHGGIALGLDRLVC 457
Cdd:PLN02850 440 -KYS-------NSFDVFIRGEEIISGAQRVHDPEL----LEKRAEEcgiDVKTISTYIDSFRYGAPPHGGFGVGLERVVM 507
|
490
....*....|....*.
gi 568910677 458 LVTGAPSIRDVIAFPK 473
Cdd:PLN02850 508 LFCGLNNIRKTSLFPR 523
|
|
| LysRS_core |
cd00775 |
Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a ... |
54-472 |
8.61e-21 |
|
Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three characteristic sequence motifs in the core domain. It is found in eukaryotes as well as some prokaryotes and archaea. However, LysRS belongs to class I aaRS's in some prokaryotes and archaea. The catalytic core domain is primarily responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate.
Pssm-ID: 238398 [Multi-domain] Cd Length: 329 Bit Score: 93.42 E-value: 8.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 54 LRLRSQMVMKMREYLCNlHGFVDIETPTLfKRTPGGA--KEFLVPSREPG-KFYsLPQSPQQFKQLLMVGGLDRYFQVAR 130
Cdd:cd00775 8 FIVRSKIISYIRKFLDD-RGFLEVETPML-QPIAGGAaaRPFITHHNALDmDLY-LRIAPELYLKRLIVGGFERVYEIGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 131 CYRDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQYSwpgdkdplvtpfpsmtfaeALATYGTDKPDtrFGMKIVD 210
Cdd:cd00775 85 NFRNEGIDLTHNPEFTMIEFYEAYADYNDMMDLTEDLFSGL-------------------VKKINGKTKIE--YGGKELD 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 211 VSDVFRntelrflqdalakpqgtvkaicvhdgakylRKEDIEFIRkfavhhfsqEVLPIFLNAKknwsspfAKFIMEEER 290
Cdd:cd00775 144 FTPPFK------------------------------RVTMVDALK---------EKTGIDFPEL-------DLEQPEELA 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 291 LELARSmeiqeedivlltAGEHEKACSLLGKLRLECAD-LLEMRgavLRDPAVfsflwVVDFPlflaKEESPteLESAHH 369
Cdd:cd00775 178 KLLAKL------------IKEKIEKPRTLGKLLDKLFEeFVEPT---LIQPTF-----IIDHP----VEISP--LAKRHR 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 370 pftapnssdihllyTEPEKVrgQHYDLVLNGNEIGGGSVRIHDAQLQRYILETLLK-------EDVKLLSHLLQALDYGA 442
Cdd:cd00775 232 --------------SNPGLT--ERFELFICGKEIANAYTELNDPFDQRERFEEQAKqkeagddEAMMMDEDFVTALEYGM 295
|
410 420 430
....*....|....*....|....*....|
gi 568910677 443 PPHGGIALGLDRLVCLVTGAPSIRDVIAFP 472
Cdd:cd00775 296 PPTGGLGIGIDRLVMLLTDSNSIRDVILFP 325
|
|
| LysU |
COG1190 |
Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
3-472 |
6.79e-20 |
|
Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase (class II) is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440803 [Multi-domain] Cd Length: 495 Bit Score: 92.40 E-value: 6.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 3 TGEIEIKVKTAELLN-ACKKLP---FEIKDfvkkTEaLRLQYRYLDL----RSFQMqynLRLRSQMVMKMREYLcNLHGF 74
Cdd:COG1190 123 TGELSVKVEELTLLSkSLRPLPekfHGLTD----PE-TRYRQRYVDLivnpEVRET---FRKRSKIIRAIRRFL-DERGF 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 75 VDIETPTLfKRTPGGA--KEF--------------------LvpsrepgkfyslpqspqqfKQLLmVGGLDRYFQVARCY 132
Cdd:COG1190 194 LEVETPML-QPIAGGAaaRPFithhnaldmdlylriapelyL-------------------KRLI-VGGFERVFEIGRNF 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 133 RDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQYSwpgdkdplvtpfpsmtfaeALATYGTDKpdTRFGMKIVDVS 212
Cdd:COG1190 253 RNEGIDTTHNPEFTMLELYQAYADYNDMMDLTEELIREA-------------------AEAVLGTTK--VTYQGQEIDLS 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 213 DVFRntelrflqdalakpqgtvkaicvhdgakylRKEDIEFIRKFAVHHFSQevlpiflnakknwsspfakfIMEEERL- 291
Cdd:COG1190 312 PPWR------------------------------RITMVEAIKEATGIDVTP--------------------LTDDEELr 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 292 ELARSMEIQEEDivllTAGehekacslLGKLrlecadLLEMRGAV----LRDPaVFsflwVVDFPlflaKEESPtelesa 367
Cdd:COG1190 342 ALAKELGIEVDP----GWG--------RGKL------IDELFEELvepkLIQP-TF----VTDYP----VEVSP------ 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 368 hhpFTAPNSSDihllytePEKV-RgqhYDLVLNGNEIGGGSVRIHDAQLQRYILETLLK-------------EDvkllsh 433
Cdd:COG1190 389 ---LAKRHRDD-------PGLTeR---FELFIAGREIANAFSELNDPIDQRERFEEQLElkaagddeampmdED------ 449
|
490 500 510
....*....|....*....|....*....|....*....
gi 568910677 434 LLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFP 472
Cdd:COG1190 450 FLRALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVILFP 488
|
|
| PTZ00401 |
PTZ00401 |
aspartyl-tRNA synthetase; Provisional |
5-473 |
1.12e-19 |
|
aspartyl-tRNA synthetase; Provisional
Pssm-ID: 173592 [Multi-domain] Cd Length: 550 Bit Score: 92.36 E-value: 1.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 5 EIEIKVKTAELLN-ACKKLPFEIKDFVKKTEA--------LRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNlHGFV 75
Cdd:PTZ00401 155 DIELKVKKIHTVTeSLRTLPFTLEDASRKESDegakvnfdTRLNSRWMDLRTPASGAIFRLQSRVCQYFRQFLID-SDFC 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 76 DIETPTLFKR-TPGGAKEFLVPSREpgKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMS 153
Cdd:PTZ00401 234 EIHSPKIINApSEGGANVFKLEYFN--RFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHlTEFVGLDVEMR 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 154 FVEQTgiqrlvegllqyswpgdkdplvtpFPSMTFAEALATYgtdkpdtrfgmkivdvsdVFRNtelrflqdaLAKPQGT 233
Cdd:PTZ00401 312 INEHY------------------------YEVLDLAESLFNY------------------IFER---------LATHTKE 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 234 VKAIC-VHDGAKYLRKEDIEFIRKFAVHHFSQEVLP--IFLNAKKNWSSpfakfimeeerlelaRSMEIQEEDIVLLTAG 310
Cdd:PTZ00401 341 LKAVCqQYPFEPLVWKLTPERMKELGVGVISEGVEPtdKYQARVHNMDS---------------RMLRINYMHCIELLNT 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 311 EHEKACSLLGKLRLECADLLemrGAVLRDPAVFSFLWVVDFPlflakeespteleSAHHPF-TAPNSSDIHLLYTepekv 389
Cdd:PTZ00401 406 VLEEKMAPTDDINTTNEKLL---GKLVKERYGTDFFISDRFP-------------SSARPFyTMECKDDERFTNS----- 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 390 rgqhYDLVLNGNEIGGGSVRIHDAQ--LQRyilETLLKEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRD 467
Cdd:PTZ00401 465 ----YDMFIRGEEISSGAQRIHDPDllLAR---AKMLNVDLTPIKEYVDSFRLGAWPHGGFGVGLERVVMLYLGLSNVRL 537
|
....*.
gi 568910677 468 VIAFPK 473
Cdd:PTZ00401 538 ASLFPR 543
|
|
| lysS |
PRK00484 |
lysyl-tRNA synthetase; Reviewed |
3-472 |
1.74e-18 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234778 [Multi-domain] Cd Length: 491 Bit Score: 88.22 E-value: 1.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 3 TGEIEIKVKTAELLN-ACKKLPfeikdfVK----KTEALRLQYRYLDL----RSFQMqynLRLRSQMVMKMREYLCNlHG 73
Cdd:PRK00484 121 TGELSVKATELTLLTkSLRPLP------DKfhglTDVETRYRQRYVDLivnpESRET---FRKRSKIISAIRRFLDN-RG 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 74 FVDIETPTLfKRTPGGAkeflvpSREPGK---------FYsLPQSPQQF-KQLLmVGGLDRYFQVARCYRDEGSRPDRQP 143
Cdd:PRK00484 191 FLEVETPML-QPIAGGA------AARPFIthhnaldidLY-LRIAPELYlKRLI-VGGFERVYEIGRNFRNEGIDTRHNP 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 144 EFTQIDIEMSFVEQTGIQRLVEGLLQYSwpgdkdplvtpfpsmtfaeALATYGTDKpdTRFGMKIVDVSDVFRntELRFl 223
Cdd:PRK00484 262 EFTMLEFYQAYADYNDMMDLTEELIRHL-------------------AQAVLGTTK--VTYQGTEIDFGPPFK--RLTM- 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 224 qdalakpqgtVKAICVHDGAKyLRKEDIEFIRKFAVHHFsqevlpifLNAKKNWSspFAKFIMEeerlelarsmeIQEEd 303
Cdd:PRK00484 318 ----------VDAIKEYTGVD-FDDMTDEEARALAKELG--------IEVEKSWG--LGKLINE-----------LFEE- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 304 ivllTAGEHekacsllgklrlecadllemrgavLRDPavfSFlwVVDFPlflaKEESPtelesahhpFTAPNSSDIHLly 383
Cdd:PRK00484 365 ----FVEPK------------------------LIQP---TF--ITDYP----VEISP---------LAKRHREDPGL-- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 384 TEpekvRgqhYDLVLNGNEIGGGSVRIHDA--QLQRYILETLLK-----------EDvkllshLLQALDYGAPPHGGIAL 450
Cdd:PRK00484 397 TE----R---FELFIGGREIANAFSELNDPidQRERFEAQVEAKeagddeamfmdED------FLRALEYGMPPTGGLGI 463
|
490 500
....*....|....*....|..
gi 568910677 451 GLDRLVCLVTGAPSIRDVIAFP 472
Cdd:PRK00484 464 GIDRLVMLLTDSPSIRDVILFP 485
|
|
| PRK12445 |
PRK12445 |
lysyl-tRNA synthetase; Reviewed |
3-472 |
5.58e-18 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 171504 [Multi-domain] Cd Length: 505 Bit Score: 86.65 E-value: 5.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 3 TGEIEIKVKTAELLN-ACKKLPFEIKDFvkKTEALRLQYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCnLHGFVDIETP 80
Cdd:PRK12445 133 TGELSIHCTELRLLTkALRPLPDKFHGL--QDQEVRYRQRYLDLiANDKSRQTFVVRSKILAAIRQFMV-ARGFMEVETP 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 81 tLFKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQT 158
Cdd:PRK12445 210 -MMQVIPGGAsaRPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYH 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 159 GIQRLVEGLLQyswpgdkdplvtpfpsmtfaeALATYGTDKPDTRFGMKIVDVSDVFRNTELRflqDALAK--PQGTVKA 236
Cdd:PRK12445 289 DLIELTESLFR---------------------TLAQEVLGTTKVTYGEHVFDFGKPFEKLTMR---EAIKKyrPETDMAD 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 237 ICVHDGAKYLRKEdiefirkfavhhfsqevlpIFLNAKKNWSspfakfimeeerlelarsmeiqeedivlltagehekac 316
Cdd:PRK12445 345 LDNFDAAKALAES-------------------IGITVEKSWG-------------------------------------- 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 317 slLGKLRLECADllEMRGAVLRDPAvfsflWVVDFPlflaKEESPTelesAHHPFTAPNSSDihllytepekvrgqHYDL 396
Cdd:PRK12445 368 --LGRIVTEIFD--EVAEAHLIQPT-----FITEYP----AEVSPL----ARRNDVNPEITD--------------RFEF 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 397 VLNGNEIGGGSVRIHDA--QLQRYILETLLK-----EDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVI 469
Cdd:PRK12445 417 FIGGREIGNGFSELNDAedQAERFQEQVNAKaagddEAMFYDEDYVTALEYGLPPTAGLGIGIDRMIMLFTNSHTIRDVI 496
|
...
gi 568910677 470 AFP 472
Cdd:PRK12445 497 LFP 499
|
|
| PLN02502 |
PLN02502 |
lysyl-tRNA synthetase |
4-472 |
5.89e-17 |
|
lysyl-tRNA synthetase
Pssm-ID: 215278 [Multi-domain] Cd Length: 553 Bit Score: 83.89 E-value: 5.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 4 GEIEIKVKTAELLNAC-KKLP---FEIKDFVKktealRLQYRYLDL-RSFQMQYNLRLRSQMVMKMREYLCNLhGFVDIE 78
Cdd:PLN02502 179 GELSIFPTSFEVLTKClLMLPdkyHGLTDQET-----RYRQRYLDLiANPEVRDIFRTRAKIISYIRRFLDDR-GFLEVE 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 79 TPTLfKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVe 156
Cdd:PLN02502 253 TPML-NMIAGGAaaRPFVTHHNDLNMDLYLRIATELHLKRLVVGGFERVYEIGRQFRNEGISTRHNPEFTTCEFYQAYA- 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 157 qtgiqrlvegllqyswpgdkdplvtpfpsmtfaealatygtdkpdtrfgmkivDVSDVFRNTELRFlqdalakpQGTVKA 236
Cdd:PLN02502 331 -----------------------------------------------------DYNDMMELTEEMV--------SGMVKE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 237 ICvhdGAKYLRKEDIEF-----IRKFAVHHFSQEVLPIFLNakknwsspfakfimeeerlELARSMEIQEEDIVLLTAGE 311
Cdd:PLN02502 350 LT---GSYKIKYHGIEIdftppFRRISMISLVEEATGIDFP-------------------ADLKSDEANAYLIAACEKFD 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 312 HE-KACSLLGKLrlecadLLEMRGAVLRDPAV---FsflwVVDFPlflaKEESPteLESAH--HPFTapnssdihllyTE 385
Cdd:PLN02502 408 VKcPPPQTTGRL------LNELFEEFLEETLVqptF----VLDHP----VEMSP--LAKPHrsKPGL-----------TE 460
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 386 pekvrgqHYDLVLNGNEIGGGSVRIHDAQLQRYILETLLK-------EDVKLLSHLLQALDYGAPPHGGIALGLDRLVCL 458
Cdd:PLN02502 461 -------RFELFINGRELANAFSELTDPVDQRERFEEQVKqhnagddEAMALDEDFCTALEYGLPPTGGWGLGIDRLVML 533
|
490
....*....|....
gi 568910677 459 VTGAPSIRDVIAFP 472
Cdd:PLN02502 534 LTDSASIRDVIAFP 547
|
|
| lysS |
PRK02983 |
bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX; |
37-472 |
1.23e-15 |
|
bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX;
Pssm-ID: 235095 [Multi-domain] Cd Length: 1094 Bit Score: 80.39 E-value: 1.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 37 RLQYRYLDL----RSFQMqynLRLRSQMVMKMREYLcNLHGFVDIETPTLfKRTPGGA--KEFLVPSREpgkfYSLPQ-- 108
Cdd:PRK02983 752 RVRQRYLDLavnpEARDL---LRARSAVVRAVRETL-VARGFLEVETPIL-QQVHGGAnaRPFVTHINA----YDMDLyl 822
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 109 --SPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTGIQRLVEGLLQyswpgdkdplvtpfpsm 186
Cdd:PRK02983 823 riAPELYLKRLCVGGVERVFELGRNFRNEGVDATHNPEFTLLEAYQAHADYDTMRDLTRELIQ----------------- 885
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 187 tfAEALATYGTD---KPDTRFGMKIVDVSDVFRntelrflqdalakpqgtvkAICVHDgakylrkediefirkfAVHH-F 262
Cdd:PRK02983 886 --NAAQAAHGAPvvmRPDGDGVLEPVDISGPWP-------------------VVTVHD----------------AVSEaL 928
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 263 SQEVLPiflnakknwSSPFakfimeEERLELARSMEIQeedivlltAGEHEKAcsllGKLrlecadLLEMRGAVLRDPAV 342
Cdd:PRK02983 929 GEEIDP---------DTPL------AELRKLCDAAGIP--------YRTDWDA----GAV------VLELYEHLVEDRTT 975
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 343 F-SFlwVVDFPLflakEESPtelesahhpFTAPNSSDIHLlytepekvrGQHYDLVLNGNEIGGGSVRIHDAQLQRYILE 421
Cdd:PRK02983 976 FpTF--YTDFPT----SVSP---------LTRPHRSDPGL---------AERWDLVAWGVELGTAYSELTDPVEQRRRLT 1031
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 568910677 422 --TLLK-----EDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGApSIRDVIAFP 472
Cdd:PRK02983 1032 eqSLLAaggdpEAMELDEDFLQALEYAMPPTGGLGMGVDRLVMLLTGR-SIRETLPFP 1088
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
72-172 |
7.63e-14 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 70.61 E-value: 7.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 72 HGFVDIETP-----TLFKRTPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGL----DRYFQVARCYRDEGSR--PD 140
Cdd:cd00768 16 LGFQEVETPiverePLLEKAGHEPKDLLPVGAENEEDLYLRPTLEPGLVRLFVSHIrklpLRLAEIGPAFRNEGGRrgLR 95
|
90 100 110
....*....|....*....|....*....|..
gi 568910677 141 RQPEFTQIDIEMsFVEQTGIQRLVEGLLQYSW 172
Cdd:cd00768 96 RVREFTQLEGEV-FGEDGEEASEFEELIELTE 126
|
|
| PTZ00385 |
PTZ00385 |
lysyl-tRNA synthetase; Provisional |
36-472 |
3.83e-13 |
|
lysyl-tRNA synthetase; Provisional
Pssm-ID: 185588 [Multi-domain] Cd Length: 659 Bit Score: 71.99 E-value: 3.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 36 LRLQYRYLDLRSFQMQYN-LRLRSQMVMKMREYLcNLHGFVDIETPTLFKRTPGG-AKEFLVPSREPGKFYSLPQSPQQF 113
Cdd:PTZ00385 214 VKYRYRFTDMMTNPCVIEtIKKRHVMLQALRDYF-NERNFVEVETPVLHTVASGAnAKSFVTHHNANAMDLFLRVAPELH 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 114 KQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTqidiemsfveqtgiqrlvegllqyswpgdkdplvtpfpSMTFAEALA 193
Cdd:PTZ00385 293 LKQCIVGGMERIYEIGKVFRNEDADRSHNPEFT--------------------------------------SCEFYAAYH 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 194 TYgtdkpdtrfgmkivdvSDVFRNTELRFLQDALAKPQGTVKAICVHDGAKYLRKEDI-EFIRKFAVHHFSQEVLPIFLN 272
Cdd:PTZ00385 335 TY----------------EDLMPMTEDIFRQLAMRVNGTTVVQIYPENAHGNPVTVDLgKPFRRVSVYDEIQRMSGVEFP 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 273 AKKNWSSPFAKFIMeeerlelarSMEIQEEDIVLLTAgehEKACSLLGKLrlecADLLEMRGAVlrDPAvfsflWVVDFP 352
Cdd:PTZ00385 399 PPNELNTPKGIAYM---------SVVMLRYNIPLPPV---RTAAKMFEKL----IDFFITDRVV--EPT-----FVMDHP 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 353 LFLakeeSPTELESAHHPFTApnssdihllytepekvrgQHYDLVLNGNEIGGGSVRIHDAQLQRYILETLL-------K 425
Cdd:PTZ00385 456 LFM----SPLAKEQVSRPGLA------------------ERFELFVNGIEYCNAYSELNDPHEQYHRFQQQLvdrqggdE 513
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 568910677 426 EDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFP 472
Cdd:PTZ00385 514 EAMPLDETFLKSLQVGLPPTAGWGMGIDRALMLLTNSSNIRDGIIFP 560
|
|
| PTZ00417 |
PTZ00417 |
lysine-tRNA ligase; Provisional |
4-472 |
5.77e-12 |
|
lysine-tRNA ligase; Provisional
Pssm-ID: 173607 [Multi-domain] Cd Length: 585 Bit Score: 68.11 E-value: 5.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 4 GEIEIKVKTAELLNAC-KKLPfeIKDFVKKTEaLRLQYRYLDLR-SFQMQYNLRLRSQMVMKMREYLcNLHGFVDIETPT 81
Cdd:PTZ00417 204 GELSIFPKETIILSPClHMLP--MKYGLKDTE-IRYRQRYLDLMiNESTRSTFITRTKIINYLRNFL-NDRGFIEVETPT 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 82 LfKRTPGGA--KEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQPEFTQIDIEMSFVEQTG 159
Cdd:PTZ00417 280 M-NLVAGGAnaRPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADFYD 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 160 IQRLVEGLLQ-------------YSWPG-DKDPL----VTPFPSMTFAEALatygtdkpdtrfgmkivdvsDVFRNTElr 221
Cdd:PTZ00417 359 LIKWSEDFFSqlvmhlfgtykilYNKDGpEKDPIeidfTPPYPKVSIVEEL--------------------EKLTNTK-- 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 222 fLQDALAKPQGTVKAICVhdgakyLRKEDIEFIRKFAVHHFSQEVLPIFLNAKKNwSSPFakFIMeeerlelarsmeiqe 301
Cdd:PTZ00417 417 -LEQPFDSPETINKMINL------IKENKIEMPNPPTAAKLLDQLASHFIENKYP-NKPF--FII--------------- 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 302 edivlltagEHEKACSLLGKLRLECADLLEMrgavlrdpavfsflwvvdFPLFLAKEESPTELESAHHPFtapnssdihl 381
Cdd:PTZ00417 472 ---------EHPQIMSPLAKYHRSKPGLTER------------------LEMFICGKEVLNAYTELNDPF---------- 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 382 lyTEPEKVRGQHYDlvlngNEIGggsvrihDAqlqryiletllkEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTG 461
Cdd:PTZ00417 515 --KQKECFSAQQKD-----REKG-------DA------------EAFQFDAAFCTSLEYGLPPTGGLGLGIDRITMFLTN 568
|
490
....*....|.
gi 568910677 462 APSIRDVIAFP 472
Cdd:PTZ00417 569 KNCIKDVILFP 579
|
|
| GAD |
pfam02938 |
GAD domain; This domain is found in some members of the GatB and aspartyl tRNA synthetases. |
228-319 |
1.70e-10 |
|
GAD domain; This domain is found in some members of the GatB and aspartyl tRNA synthetases.
Pssm-ID: 397199 [Multi-domain] Cd Length: 94 Bit Score: 57.66 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 228 AKPQGTVKAICVHDGAKYLRKEdIEFIRKFAVHHFSQEVlpIFLNAKKN-WSSPFAKFIMEEERLELARSMEIQEEDIVL 306
Cdd:pfam02938 5 LKSGGSVKALRVPGAAGLSRKE-IDELERFAKEYGAKGL--AWIKVEGGgHTGPIAKFLTEEEVEKLLEAVGAEDGDALL 81
|
90
....*....|...
gi 568910677 307 LTAGEHEKACSLL 319
Cdd:pfam02938 82 FVADKKKTVNKAL 94
|
|
| genX |
TIGR00462 |
EF-P lysine aminoacylase GenX; Many Gram-negative bacteria have a protein closely homologous ... |
396-470 |
4.04e-09 |
|
EF-P lysine aminoacylase GenX; Many Gram-negative bacteria have a protein closely homologous to the C-terminal region of lysyl-tRNA synthetase (LysS). Multiple sequence alignment of these proteins with the homologous regions of collected LysS proteins shows that these proteins form a distinct set rather than just similar truncations of LysS. The protein is termed GenX after its designation in E. coli. Interestingly, genX often is located near a homolog of lysine-2,3-aminomutase. Its function is unknown. [Unknown function, General]
Pssm-ID: 273090 [Multi-domain] Cd Length: 290 Bit Score: 57.95 E-value: 4.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 396 LVLNGNEIGGGSVRIHDAQLQRYILET-------LLKEDVKLLSHLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDV 468
Cdd:TIGR00462 209 LYIKGLELANGFHELTDAAEQRRRFEAdnalrkaLGLPRYPLDERFLAALEAGLPECSGVALGVDRLLMLALGADSIDDV 288
|
..
gi 568910677 469 IA 470
Cdd:TIGR00462 289 LA 290
|
|
| asnC |
PRK03932 |
asparaginyl-tRNA synthetase; Validated |
402-476 |
1.21e-08 |
|
asparaginyl-tRNA synthetase; Validated
Pssm-ID: 235176 [Multi-domain] Cd Length: 450 Bit Score: 57.04 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 402 EIGGGSVRIHDAQL--QRYILETLLKEDvkllshlLQ-ALD---YGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPKSY 475
Cdd:PRK03932 373 EIIGGSQREERLDVleARIKELGLNKED-------YWwYLDlrrYGSVPHSGFGLGFERLVAYITGLDNIRDVIPFPRTP 445
|
.
gi 568910677 476 R 476
Cdd:PRK03932 446 G 446
|
|
| PTZ00425 |
PTZ00425 |
asparagine-tRNA ligase; Provisional |
363-478 |
8.33e-07 |
|
asparagine-tRNA ligase; Provisional
Pssm-ID: 240414 [Multi-domain] Cd Length: 586 Bit Score: 51.56 E-value: 8.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 363 ELESAHHPFTAPN-----------SSDIHLLY---TEPEKVRGQHYDLVLNGNEIGGGSVRIHDAQ-LQRYILETLLKED 427
Cdd:PTZ00425 456 DLQSEHERFVAEQifkkpvivynyPKDLKAFYmklNEDQKTVAAMDVLVPKIGEVIGGSQREDNLErLDKMIKEKKLNME 535
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 568910677 428 VKLLSHLLQalDYGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPKsYRGQ 478
Cdd:PTZ00425 536 SYWWYRQLR--KFGSHPHAGFGLGFERLIMLVTGVDNIKDTIPFPR-YPGH 583
|
|
| PRK09350 |
PRK09350 |
elongation factor P--(R)-beta-lysine ligase; |
399-468 |
3.82e-06 |
|
elongation factor P--(R)-beta-lysine ligase;
Pssm-ID: 236474 [Multi-domain] Cd Length: 306 Bit Score: 48.77 E-value: 3.82e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568910677 399 NGNEIGGGSVRIHDA--QLQRYILETLLKEDVKLLS-----HLLQALDYGAPPHGGIALGLDRLVCLVTGAPSIRDV 468
Cdd:PRK09350 230 KGIELANGFHELTDAreQRQRFEQDNRKRAARGLPQqpideNLIAALEAGLPDCSGVALGVDRLIMLALGAESISEV 306
|
|
| PLN02603 |
PLN02603 |
asparaginyl-tRNA synthetase |
440-473 |
6.84e-06 |
|
asparaginyl-tRNA synthetase
Pssm-ID: 178213 [Multi-domain] Cd Length: 565 Bit Score: 48.82 E-value: 6.84e-06
10 20 30
....*....|....*....|....*....|....
gi 568910677 440 YGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPK 473
Cdd:PLN02603 525 YGSVPHAGFGLGFERLVQFATGIDNIRDAIPFPR 558
|
|
| PLN02532 |
PLN02532 |
asparagine-tRNA synthetase |
440-475 |
1.07e-04 |
|
asparagine-tRNA synthetase
Pssm-ID: 215291 [Multi-domain] Cd Length: 633 Bit Score: 44.86 E-value: 1.07e-04
10 20 30
....*....|....*....|....*....|....*.
gi 568910677 440 YGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPKSY 475
Cdd:PLN02532 593 HGTVKHSGFSLGFELMVLFATGLPDVRDAIPFPRSW 628
|
|
| PLN02221 |
PLN02221 |
asparaginyl-tRNA synthetase |
440-478 |
7.62e-04 |
|
asparaginyl-tRNA synthetase
Pssm-ID: 177867 [Multi-domain] Cd Length: 572 Bit Score: 42.29 E-value: 7.62e-04
10 20 30
....*....|....*....|....*....|....*....
gi 568910677 440 YGAPPHGGIALGLDRLVCLVTGAPSIRDVIAFPKsYRGQ 478
Cdd:PLN02221 532 YGTVKHCGFGLGFERMILFATGIDNIRDVIPFPR-YPGK 569
|
|
| PRK06462 |
PRK06462 |
asparagine synthetase A; Reviewed |
54-193 |
3.91e-03 |
|
asparagine synthetase A; Reviewed
Pssm-ID: 235808 [Multi-domain] Cd Length: 335 Bit Score: 39.62 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 54 LRLRSQMVMKMREYLCNlHGFVDIETPTLFKRT----PGGAKEFL-VPSRE-PGKFYSLPQSPQQFKQLlMVGGLDRYFQ 127
Cdd:PRK06462 30 LKVQSSILRYTREFLDG-RGFVEVLPPIISPSTdplmGLGSDLPVkQISIDfYGVEYYLADSMILHKQL-ALRMLGKIFY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910677 128 VARCYRDEGSRPDRQP---EFTQIDIEMSFVEQTGIQRLVEGLLQYSWPGDKDP--------------LVTPFPSMTFAE 190
Cdd:PRK06462 108 LSPNFRLEPVDKDTGRhlyEFTQLDIEIEGADLDEVMDLIEDLIKYLVKELLEEhedeleffgrdlphLKRPFKRITHKE 187
|
...
gi 568910677 191 ALA 193
Cdd:PRK06462 188 AVE 190
|
|
| |
